1. Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants’ Environmental Health (ISA) Study
- Author
-
Mora, Ana María, Córdoba, Leonel, Cano, Juan Camilo, Hernandez-Bonilla, David, Pardo, Larissa, Schnaas, Lourdes, Smith, Donald R, Menezes-Filho, José A, Mergler, Donna, Lindh, Christian H, Eskenazi, Brenda, and van Wendel de Joode, Berna more...
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Perinatal Period - Conditions Originating in Perinatal Period ,Social Determinants of Health ,Clinical Research ,Pregnancy ,Women's Health ,Pediatric ,Conditions Affecting the Embryonic and Fetal Periods ,Neurosciences ,Reproductive health and childbirth ,Environmental Exposure ,Environmental Health ,Ethylenethiourea ,Female ,Fungicides ,Industrial ,Humans ,Infant ,Male ,Maneb ,Manganese ,Maternal Exposure ,Neurodevelopmental Disorders ,Zineb ,Environmental Sciences ,Medical and Health Sciences ,Toxicology ,Biomedical and clinical sciences ,Environmental sciences ,Health sciences - Abstract
BackgroundAlthough growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited.ObjectiveWe examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica.MethodsWe measured urinary ETU, hair Mn, and blood Mn concentrations in samples collected 1-3 times during pregnancy from mothers enrolled in the Infants' Environmental Health (ISA) study. We then assessed neurodevelopment in their 1-y-old infants using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). We estimated exposure-outcome associations using linear regression models adjusted for maternal education, parity, gestational age at birth, child age, Home Observation for Measurement of the Environment score, and location of neurodevelopmental assessment.ResultsMedian (P25-P75) urinary ETU, hair Mn, and blood Mn measured during pregnancy were 3.3 μg/L (2.4-4.9; specific gravity-corrected), 1.7 μg/g (0.9-4.1), and 24.0 μg/L (20.3-28.0), respectively. Among girls, higher ETU was associated with lower social-emotional scores [β per 10-fold increase=-7.4 points (95% CI: -15.2, 0.4)], whereas higher hair Mn was associated with lower cognitive scores [-3.0 (-6.1, 0.1)]. Among boys, higher hair Mn was associated with lower social-emotional scores [-4.6 (-8.5, -0.8)]. We observed null associations for blood Mn, language, and motor outcomes.ConclusionsOur findings indicate that maternal exposure to mancozeb and excess Mn during pregnancy may have adverse and sex-specific effects on infant neurodevelopment. https://doi.org/10.1289/EHP1955. more...
- Published
- 2018