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Patients with limb girdle muscular dystrophy (LGMD) R2/2B (dysferlinopathy) lose the ability to independently move into standing from a seated position (STS) prior to loss of independent ambulation. Clinically, individuals report this impacts their ability to socialise or to work, however there are no studies evaluating this. The aim of this study was to examine the impact of loss of STS on social participation/employment in individuals with dysferlinopathy. We examined the baseline visit data of 205 participants in the Clinical Outcome study for Dysferlinopathy, a two-year, 16-site natural history study. Data analysed included scores of STS from the North Star assessment for limb-girdle type muscular dystrophies (NSAD), responses to the participant-reported Activity limitations for patients with upper and/or lower limb impairments (ACTIVLIM) and participant-reported responses to the Quality of Life in Genetic Neuromuscular Disease Questionnaire (QOLgNMD). Chi square test for association (χ2) were used to test the relationship between clinician-reported ability to STS and participant-reported ability to complete activities requiring STS. Statistically significant associations were found between the following variables: clinician-reported ability to STS (NSAD) and patient-reported ability to get on/off a toilet, in/out of a car (ACTIVLIM), how often getting to the toilet restricted activities outside the home and how often participants felt able to leave the house alone (QOLgNMD). Loss of ability to STS was associated with reduced social participation and employment, which can be detected by deterioration on NSAD or ACTIVLIM STS items. The use of equipment or support from others is helpful in managing difficulties with STS, which enables people with dysferlinopathy to remain socially active or employed. Clinicians should proactively instigate early referrals to equipment and wheelchair providers after any deterioration on NSAD or ACTIVLIM STS scores, regardless of ambulatory status. [ABSTRACT FROM AUTHOR]