1. Synthesis of new thiazolylthiazolidinylbenzothiazoles and thiazolylazetidinylbenzothiazoles as potential insecticidal, antifungal, and antibacterial agents.
- Author
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Singh T, Srivastava VK, Saxena KK, Goel SL, and Kumar A
- Subjects
- Animals, Anti-Bacterial Agents analysis, Anti-Bacterial Agents toxicity, Antifungal Agents analysis, Antifungal Agents toxicity, Azetidines analysis, Azetidines toxicity, Benzothiazoles analysis, Benzothiazoles toxicity, Candida drug effects, Candida growth & development, Chloramphenicol standards, Chloramphenicol toxicity, Escherichia coli drug effects, Escherichia coli growth & development, Fluconazole standards, Fluconazole toxicity, Insecticides analysis, Insecticides toxicity, Molecular Structure, Parathion standards, Parathion toxicity, Periplaneta drug effects, Periplaneta growth & development, Staphylococcus aureus drug effects, Staphylococcus aureus growth & development, Anti-Bacterial Agents chemical synthesis, Antifungal Agents chemical synthesis, Azetidines chemical synthesis, Benzothiazoles chemical synthesis, Insecticides chemical synthesis
- Abstract
A series of 2-{[2'-(3''-chloro-2''-oxo-4''-substitutedaryl-1''-azetidinyl)-1',3'-thiazol-4'-yl] thio}benzothiazoles (4a-4e) and 2-{[(2'-(2''-substitutedaryl-4''-thiazolidinon-3''-yl)-1',3'-thiazol-4'-yl]thio}benzothiazoles (5a-5e) have been synthesized from 2-[(2'-substitutedarylidenylimino-1',3'-thiazol-4'-yl)thio]benzothiazoles (3a-3e). The structure of these compounds has been elucidated by elemental (C, H, N) and spectral (IR, (1)H-NMR, Mass) analysis. Furthermore, compounds 3a-3e, 4a-4e, and 5a-5e were screened for insecticidal activity against Periplaneta americana and antifungal, antibacterial activities in vitro against different strains of fungi and bacteria. Out of the fifteen compounds tested, compound 5b, 2-{[2'-(2''-p-hydroxy-m-methoxyphenyl)-4''-thiazolidinon-3''-yl)-1',3'-thiazol-4'-yl]thio}benzothiazole, was found to possess most prominent insecticidal activity.
- Published
- 2006
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