2,903 results on '"Parasitic disease"'
Search Results
2. The Impact of Parasitic Infection on Multiple Sclerosis and Nephrotic Syndrome
- Author
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Monica Refaat Hakeem Saweries, Demonstrator
- Published
- 2024
3. A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines
- Published
- 2024
4. The battle against the introduced pathogenic monogenean Gyrodactylus salaris in Norwegian Atlantic salmon rivers and fish farms.
- Author
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Mo, Tor Atle
- Subjects
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FISH farming , *ATLANTIC salmon , *RAINBOW trout , *FISH kills , *PARASITIC diseases - Abstract
The introduced salmonid ectoparasite Gyrodactylus salaris has been detected on Atlantic salmon in 53 Norwegian rivers and in 39 Norwegian fish farms. In affected rivers, the mortality of Atlantic salmon juveniles is very high, estimated to a mean of 86%. G. salaris has been considered one of the biggest threats to wild Norwegian Atlantic salmon stocks. With various measures, the authorities have reduced the potential for further spread of the parasite to new rivers and fish farms, and G. salaris has been eradicated from 43 rivers and all fish farms. Furthermore, the eradication process is almost completed in five affected rivers located at the Norwegian west coast, while preparations for the eradication in the remaining five rivers in the southeastern part of Norway have begun. The goal of Norwegian management is to eradicate the introduced pathogenic G. salaris strains from all occurrences in Norway. In fish farms, the parasite has been removed by mandatory slaughter of infected fish. In rivers, G. salaris has mostly been removed by killing all the fish hosts with rotenone. The indigenous genetic Atlantic salmon stocks are re‐established after eradication of the parasite. New methods are developed using chemicals that kill the parasite without killing fish in the rivers. Norwegian authorities have so far used more than NOK 1.5 billion on research, monitoring and combating G. salaris. However, the benefits are considered many times greater than the spending. Without control measures, G. salaris would likely have spread to new Atlantic salmon rivers where the same catastrophic outcome had to be expected. The Norwegian authorities seem to meet the goal in their long‐term work to halt the spread of G. salaris and to eradicate the parasite in affected rivers. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Study of the Impact of Irrigation with Wastewater Through the Evaluation of Intestinal Parasite Load in the Case of Ouad Rha in Ouazzane, a Northern Moroccan City
- Author
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Chriqui, Ahmed, Mouniane, Yassine, Arabi, Rida, El-Khadir, Issam, Benchrifa, Mohammed, Mabrouki, Jamal, Keridou, Ali, Hmouni, Driss, Kacprzyk, Janusz, Series Editor, Mabrouki, Jamal, editor, and Azrour, Mourade, editor
- Published
- 2024
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- View/download PDF
6. A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
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- 2023
7. Detection of Cryptosporidium spp. in Wild Rats (Rattus spp.) in Surabaya, East Java
- Author
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Ponasari Galuh Pratama, Endang Suprihati, Lucia Tri Suwanti, Mufasirin, Poedji Hastutiek, Boedi Setiawan, Heni Puspitasari, and Elly Nur Indasari
- Subjects
cryptosporidium ,parasitic disease ,surabaya ,wild rats ,Veterinary medicine ,SF600-1100 - Abstract
Cryptosporidiosis is a waterborne zoonosis caused by Cryptosporidium, which is a parasite that causes infection of the small intestine and leads to acute diarrhea in both humans and animals. Wild rats (Rattus spp.) are known to carry many zoonotic pathogens including Cryptosporidium. Given their close proximity to humans in urban environments, the likelihood of disease transmission is high. This study aims to detect the Cryptosporidium spp. infection in wild rats in Surabaya City, East Java Province. Intestinal fecal samples were collected using necropsy. The flotation test and Ziehl-Neelsen stain were used to observe the presence of Cryptosporidium under the microscope. The results showed that 69 samples were positive for Cryptosporidium spp. in the oocyst stage, which appeared dark pink with a clear cavity and the size of the oocysts ranged from 2-6 μm. The high incidence of cryptosporidiosis in wild rats is a potential health threat to both animals and humans.
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- 2024
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- View/download PDF
8. Identification and coregulation pattern analysis of long noncoding RNAs in the mouse brain after Angiostrongylus cantonensis infection
- Author
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Dong-Hui Cheng, Tian-Ge Jiang, Wen-Bo Zeng, Tian-Mei Li, Yi-Dan Jing, Zhong-Qiu Li, Yun-Hai Guo, and Yi Zhang
- Subjects
Angiostrongylus cantonensis ,Long noncoding RNA ,RNA-Seq ,Angiostrongyliasis ,Parasitic disease ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Angiostrongyliasis is a highly dangerous infectious disease. Angiostrongylus cantonensis larvae migrate to the mouse brain and cause symptoms, such as brain swelling and bleeding. Noncoding RNAs (ncRNAs) are novel targets for the control of parasitic infections. However, the role of these molecules in A. cantonensis infection has not been fully clarified. Methods In total, 32 BALB/c mice were randomly divided into four groups, and the infection groups were inoculated with 40 A. cantonensis larvae by gavage. Hematoxylin and eosin (H&E) staining and RNA library construction were performed on brain tissues from infected mice. Differential expression of long noncoding RNAs (lncRNAs) and mRNAs in brain tissues was identified by high-throughput sequencing. The pathways and functions of the differentially expressed lncRNAs were determined by Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses. The functions of the differentially expressed lncRNAs were further characterized by lncRNA‒microRNA (miRNA) target interactions. The potential host lncRNAs involved in larval infection of the brain were validated by quantitative real-time polymerase chain reaction (qRT‒PCR). Results The pathological results showed that the degree of brain tissue damage increased with the duration of infection. The transcriptome results showed that 859 lncRNAs and 1895 mRNAs were differentially expressed compared with those in the control group, and several lncRNAs were highly expressed in the middle–late stages of mouse infection. GO and KEGG pathway analyses revealed that the differentially expressed target genes were enriched mainly in immune system processes and inflammatory response, among others, and several potential regulatory networks were constructed. Conclusions This study revealed the expression profiles of lncRNAs in the brains of mice after infection with A. cantonensis. The lncRNAs H19, F630028O10Rik, Lockd, AI662270, AU020206, and Mexis were shown to play important roles in the infection of mice with A. cantonensis infection. Graphical Abstract
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- 2024
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9. Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease
- Author
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Karina A. Stadler, Lesly J. Ortiz-Joya, Amit Singh Sahrawat, Christoph Buhlheller, Karl Gruber, Tea Pavkov-Keller, Treasa B. O’Hagan, Alba Guarné, Sergio Pulido, Marcel Marín-Villa, Klaus Zangger, and Nina Gubensäk
- Subjects
American trypanosomiasis ,Parasitic disease ,NMR ,Akt/PKB ,PH domain ,Medicine ,Science - Abstract
Abstract According to the World Health Organization, Chagas disease (CD) is the most prevalent poverty-promoting neglected tropical disease. Alarmingly, climate change is accelerating the geographical spreading of CD causative parasite, Trypanosoma cruzi, which additionally increases infection rates. Still, CD treatment remains challenging due to a lack of safe and efficient drugs. In this work, we analyze the viability of T. cruzi Akt-like kinase (TcAkt) as drug target against CD including primary structural and functional information about a parasitic Akt protein. Nuclear Magnetic Resonance derived information in combination with Molecular Dynamics simulations offer detailed insights into structural properties of the pleckstrin homology (PH) domain of TcAkt and its binding to phosphatidylinositol phosphate ligands (PIP). Experimental data combined with Alpha Fold proposes a model for the mechanism of action of TcAkt involving a PIP-induced disruption of the intramolecular interface between the kinase and the PH domain resulting in an open conformation enabling TcAkt kinase activity. Further docking experiments reveal that TcAkt is recognized by human inhibitors PIT-1 and capivasertib, and TcAkt inhibition by UBMC-4 and UBMC-6 is achieved via binding to TcAkt kinase domain. Our in-depth structural analysis of TcAkt reveals potential sites for drug development against CD, located at activity essential regions.
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- 2024
- Full Text
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10. Oral Sex as a Potential Route for Toxoplasma Gondii Transmission: Experiment with Human Semen and Laboratory Mice Model.
- Author
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Ullmann, Jana, Kodym, Petr, Flegr, Jaroslav, Berenová, Dagmar, Jirsová, Simona, and Kaňková, Šárka
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ORAL sex ,LABORATORY mice ,TOXOPLASMA gondii ,ANIMAL disease models ,ORAL drug administration ,MICE ,SEMEN analysis ,SEMEN - Abstract
Purpose: Toxoplasma gondii is one of the most widespread parasites in the human population globally. Several modes of its transmission have been proposed: some are well-researched and confirmed, others remain unconfirmed. One unconfirmed hypothesis pertains to potential transmission of Toxoplasma gondii via oral sex (fellatio) in humans. A recent study found tissue cysts in the semen of men with latent toxoplasmosis. Therefore, we aimed to test the hypothesis of Toxoplasma gondii transmission through oral sex experimentally. Methods: Eighty-two laboratory mice were orally administered semen samples from 41 men with latent toxoplasmosis. These semen samples were examined for the presence of Toxoplasma gondii DNA using PCR. Results: We detected Toxoplasma gondii DNA in three of the 41 semen samples from men with latent toxoplasmosis. Oral administration of semen samples to laboratory mice did not result in parasite transmission. Conclusion: We have not demonstrated the transmission of Toxoplasma to mice by oral exposure to semen from infected men. While this does not conclusively rule out the possibility of such transmission in humans, the results suggest that, if it does occur, this mode of transmission is likely infrequent. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease.
- Author
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Stadler, Karina A., Ortiz-Joya, Lesly J., Singh Sahrawat, Amit, Buhlheller, Christoph, Gruber, Karl, Pavkov-Keller, Tea, O'Hagan, Treasa B., Guarné, Alba, Pulido, Sergio, Marín-Villa, Marcel, Zangger, Klaus, and Gubensäk, Nina
- Subjects
- *
CHAGAS' disease , *DRUG target , *TRYPANOSOMA cruzi , *PHOSPHOINOSITIDES , *NUCLEAR magnetic resonance , *MOLECULAR dynamics - Abstract
According to the World Health Organization, Chagas disease (CD) is the most prevalent poverty-promoting neglected tropical disease. Alarmingly, climate change is accelerating the geographical spreading of CD causative parasite, Trypanosoma cruzi, which additionally increases infection rates. Still, CD treatment remains challenging due to a lack of safe and efficient drugs. In this work, we analyze the viability of T. cruzi Akt-like kinase (TcAkt) as drug target against CD including primary structural and functional information about a parasitic Akt protein. Nuclear Magnetic Resonance derived information in combination with Molecular Dynamics simulations offer detailed insights into structural properties of the pleckstrin homology (PH) domain of TcAkt and its binding to phosphatidylinositol phosphate ligands (PIP). Experimental data combined with Alpha Fold proposes a model for the mechanism of action of TcAkt involving a PIP-induced disruption of the intramolecular interface between the kinase and the PH domain resulting in an open conformation enabling TcAkt kinase activity. Further docking experiments reveal that TcAkt is recognized by human inhibitors PIT-1 and capivasertib, and TcAkt inhibition by UBMC-4 and UBMC-6 is achieved via binding to TcAkt kinase domain. Our in-depth structural analysis of TcAkt reveals potential sites for drug development against CD, located at activity essential regions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
12. Parasitic Granulomatous Dermatitis Caused by Pelodera spp. in Buffalo on Marajó Island, Pará.
- Author
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Barbosa, Camila Cordeiro, Ferreira Filho, Carlos Eduardo da Silva, Oliveira, Carlos Magno Chaves, Ferreira, Tatiane Teles Albernaz, Brito, Marilene de Farias, de Melo, Stella Maris Pereira, Paz, Milena Carolina, Pavarini, Saulo Petinatti, Driemeier, David, and Barbosa, José Diomedes
- Subjects
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MULTINUCLEATED giant cells , *AGRICULTURE , *SKIN inflammation , *WATER buffalo , *MAMMARY glands , *NASAL mucosa , *NECK - Abstract
Simple Summary: Buffalo are country animals, with great adaptability, and thrive in diverse environments. The State of Pará has the largest herd of buffalo in Brazil, which can be found mainly on Marajó Island in the northern region of the state. As a result, buffalo farming has become widespread in Brazil, and it offers several products to the consumer market. However, in the State of Pará, skin diseases stand out among the diseases that affect this species. This study reports the first case of dermatitis caused by Pelodera spp. in buffalo (Bubalus bubalis) on Marajó Island, Pará. This is the first report of parasitic granulomatous dermatitis caused by Pelodera spp. in a buffalo. The affected buffalo was about seven years old, was a female of the Murrah breed and belonged to a property located on Marajó Island in the State of Pará. During the clinical examination, the animal was in a standing position and presented several multifocal nodular and placoid masses throughout the body, mostly on the forelimbs, hindlimbs, abdomen, mammary glands, perineum, vulva and tail. These masses were also observed on the nasal mucosa, head, neck, back and chest. On macroscopic examination, the skin had several multifocal-to-coalescent sessile nodular and placoid lesions. Histopathology of the skin showed a marked reduction in the number of hair follicles. In the superficial dermis, there was significant multifocal-to-coalescent inflammatory infiltration, consisting of macrophages, epithelioid macrophages, lymphocytes, plasma cells and multinucleated giant cells. In the remaining hair follicles, there were numerous cross and longitudinal sections of small rhabditoid nematodes characterized by a thin cuticle, platymyarian musculature, an intestinal tract, a rhabditiform esophagus and lateral alae (morphologically compatible with Pelodera spp.). The diagnosis of parasitic dermatitis was confirmed by histopathological skin lesions associated with the presence of intralesional rhabditiform larvae morphologically compatible with Pelodera spp. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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13. RESOLUTION OF CLINICAL SIGNS OF SARCOPTIC MANGE IN AMERICAN BLACK BEARS (URSUS AMERICANUS), IN IVERMECTIN-TREATED AND NONTREATED INDIVIDUALS.
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Tiffin, Hannah S., Brown, Justin D., Ternent, Mark, Snavely, Brandon, Carrollo, Emily, Kibe, Ethan, Buderman, Frances E., Mullinax, Jennifer M., and Machtinger, Erika T.
- Abstract
The parasitic mite Sarcoptes scabiei causes mange in nearly 150 species of mammals by burrowing under the skin, triggering hypersensitivity responses that can alter animals' behavior and result in extreme weight loss, secondary infections, and even death. Since the 1990s, sarcoptic mange has increased in incidence and geographic distribution in Pennsylvania black bear (Ursus americanus) populations, including expansion into other states. Recovery from mange in free-ranging wildlife has rarely been evaluated. Following the Pennsylvania Game Commission's standard operating procedures at the time of the study, treatment consisted of one subcutaneous injection of ivermectin. To evaluate black bear survival and recovery from mange, from 2018 to 2020 we fitted 61 bears, including 43 with mange, with GPS collars to track their movements and recovery. Bears were collared in triplicates according to sex and habitat, consisting of one bear without mange (healthy control), one scabietic bear treated with ivermectin when collared, and one untreated scabietic bear. Bears were reevaluated for signs of mange during annual den visits, if recaptured during the study period, and after mortality events. Disease status and recovery from mange was determined based on outward gross appearance and presence of S. scabiei mites from skin scrapes. Of the 36 scabietic bears with known recovery status, 81% fully recovered regardless of treatment, with 88% recovered with treatment and 74% recovered without treatment. All bears with no, low, or moderate mite burdens (<16 mites on skin scrapes) fully recovered from mange (n=20), and nearly half of bears with severe mite burden (≥16 mites) fully recovered (n=5, 42%). However, nonrecovered status did not indicate mortality, and mange-related mortality was infrequent. Most bears were able to recover from mange irrespective of treatment, potentially indicating a need for reevaluation of the mange wildlife management paradigm. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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14. Microbiome and Malnutrition in Pregnancy (MMiP) (MMiP)
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The Hospital for Sick Children, University of Toronto, University of Calgary, Dalhousie University, University of Alberta, Canadian Institutes of Health Research (CIHR), and Dr Zulfiqar Ahmed Bhutta, Professor Zulfiqar A Bhutta MBBS, FRCPCH, FAAP, PhD
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- 2023
15. Microbiome and Malnutrition in Pregnancy (MMIP)
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Unity Health Toronto, University of Toronto, University of Calgary, Dalhousie University, Aga Khan University, University of Alberta, National Institute of Allergy and Infectious Diseases (NIAID), Canadian Institutes of Health Research (CIHR), and John Parkinson, Senior Scientist
- Published
- 2023
16. Cystic Echinococcosis in Hospitalized Children from Western Romania: A 25-Year Retrospective Study.
- Author
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Paduraru, Ana Alexandra, Lupu, Maria Alina, Popoiu, Calin Marius, Stanciulescu, Maria Corina, Tirnea, Livius, Boia, Eugen Sorin, and Olariu, Tudor Rares
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HOSPITAL care of children ,ECHINOCOCCOSIS ,ECHINOCOCCUS granulosus ,PARASITIC diseases ,HEPATIC echinococcosis ,AGE groups - Abstract
Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by Echinococcus granulosus. We aimed to assess the epidemiological aspects of the disease in hospitalized children from Western Romania, a well-known endemic area for CE. We retrospectively investigated the medical records of children hospitalized between 1998 and 2022. A total of 144 patients were included, and 58.3% were from rural areas. The number of cases increased with age, from 9% in the age group 3–5 years to 59.7% in the age group 11–17 years. The liver was more frequently affected (65.3%), and a significant association between gender and the affected organ was noted; liver cysts were more frequently diagnosed in girls, while lung cysts were recorded mostly in boys. Complications were more frequently reported in patients with pulmonary CE compared to hepatic CE (p = 0.04). Boys had more complications (16/23, 69.6%) compared to girls (7/23, 30.4%) (p = 0.03). A third of the children were hospitalized for more than 14 days, and multiple hospitalizations were recorded in 31.3% of the patients. This paper provides new insights into the epidemiologic features of cystic echinococcosis in children from Western Romania. Our findings indicate that exposure to the parasite starts in childhood, and the rate of hospitalization increases with age. Public health strategies should be implemented and permanently improved in order to lower the prevalence of CE in children. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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17. First Identification of Trichinella pseudospiralis in a Golden Jackal (Canis aureus) in Romania.
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Marin, Ana-Maria, Popovici, Dan-Cornel, Marucci, Gianluca, Cherchi, Simona, and Mederle, Narcisa
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TRICHINELLA ,CANIS ,NEMATODES ,REPTILES - Abstract
Trichinella spp. are etiological zoonotic agents that spread throughout the world and affect mammals, birds, and reptiles. Within this genus, Trichinella pseudospiralis is the only recognized non-encapsulated species known to infect mammals and birds. This species has been reported in the majority of European countries, and the real epidemiological scenario of this species remains to be defined because its detection in mammals is much lower than that of the capsulated species. The aim of this study was to examine the presence of Trichinella larvae isolated from the muscles of a jackal from the hunting fund of 36 Murfatlar, Constanta County, Romania. The muscle samples were examined by artificial digestion, and the larvae were identified at the species level by multiplex PCR. The presence of larvae belonging to T. pseudospiralis, a species more frequently reported in carnivorous birds, was observed. This study describes the first identification of T. pseudospiralis in a jackal. The results suggest that there is an urgent need to investigate which species of mammals and/or birds act as reservoirs for this zoonotic nematode in Romania. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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18. Extra-lymphatic Filariasis: A Study of Three Interesting Cases
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Yogesh Vishnu Badak, Anuja Arjun Yadav, Vaibhav Bhika Bari, Sandhya Unmesh Bholay, and Prachi Bhaskar Gholap
- Subjects
breast ,disabling ,parasitic disease ,soft-tissue ,spleen ,Microbiology ,QR1-502 ,Chemistry ,QD1-999 - Abstract
Filariasis is a chronic disabling parasitic disease that causes a major public health problem in tropical countries like India. Wuchereria bancrofti is associated with almost 99.4% of cases. Filariasis not only affects the structure and function of lymphatic vessels but is also associated with extra-lymphatic pathology and diseases. Lymphatic filariasis is commonly found throughout the tropics and subtropics. While lymph nodes are the common sites, unusual sites include the breast, spleen, subcutaneous tissue, thyroid, bone marrow, urinary tract, sputum, bronchial washing, pleural and pericardial fluid. Patients from endemic areas presenting with swelling should be evaluated for filariasis. Here in present case series, the authors discussed three cases: filariasis of the breast with fibroadenoma, soft-tissue nodule, and splenic lesions, due to their extreme rarity and unusual sites. In the first case, 20 years old female patient presented with a lump in the left breast. The Complete Blood Cell (CBC) revealed eosinophilia, but peripheral smears did not show the presence of microfilariae. On Fine Needle Aspiration Cytology (FNAC), smears showed Wuchereria bancrofti microfilaria in the background of fibroadenoma. The patient was treated with Diethylcarbamazine (DEC) for 21 days. Repeat CBC revealed a decrease in the absolute eosinophil count. Lumpectomy for fibroadenoma was performed, which showed fragments (dead) of the microfilarial parasite. The association of filariasis with fibroadenoma is possibly due to pre-existing subclinical filariasis when the neoplasm developed, as the patient hails from an endemic area. Filariasis presenting as a soft-tissue nodule is an uncommon incidence. In the second case discussed here, 30 years old female patient had soft-tissue swelling over the left elbow. Peripheral smear only revealed eosinophilia without any parasites. On FNAC, smears showed Wuchereria bancrofti microfilaria, along with lymphoid cells and a few eosinophils. The swelling subsided with DEC treatment, and repeat CBC showed a decrease in the absolute eosinophil count. The third case discussed here, involved an unknown 35 years old male, who was brought dead to the hospital. No clinical details were available. On autopsy, the spleen showed multiple white patches, ranging in size from 0.2 to 0.5 cm in diameter. All other organs were unremarkable. Microscopy showed many granulomas and numerous dead fragmented microfilariae. It was a case of isolated splenic filariasis, which is a rarely diagnosed entity. These unique cases will raise awareness of diagnosing and instituting proper therapy.
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- 2024
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19. Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
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QIMR Berghofer Medical Research Institute, Southern Star Research Pty Ltd., Swiss BioQuant A.G., Switzerland, and Children's Health Queensland Hospital and Health Service
- Published
- 2022
20. Cystic Echinococcosis in Hospitalized Adult Patients from Western Romania: 2007–2022.
- Author
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Paduraru, Ana Alexandra, Lupu, Maria Alina, Sima, Laurentiu, Cozma, Gabriel Veniamin, Olariu, Sorin Dan, Chiriac, Sorin Dan, Totolici, Bogdan Dan, Pirvu, Catalin Alexandru, Lazar, Fulger, Nesiu, Alexandru, Mihu, Alin Gabriel, Cumpanas, Alin Adrian, Cretu, Octavian Marius, and Olariu, Tudor Rares
- Subjects
ARACHNOID cysts ,HOSPITAL patients ,ECHINOCOCCOSIS ,LENGTH of stay in hospitals ,ECHINOCOCCUS granulosus ,ZOONOSES - Abstract
Cystic echinococcosis (CE) is a neglected parasitic disease caused by the tapeworm Echinococcus granulosus. The aim of this study was to assess the epidemiological features of human cystic echinococcosis in patients from Western Romania. We retrospectively investigated the medical records of patients hospitalized with CE between 1 January 2007 and 1 September 2022. A total of 366 patients (range 18–90 years) were recorded. The number of hospitalized individuals was higher in patients aged 50–59 years (83/366, 22.7%), in females (194/366, 53%), and in residents of rural areas (225/366, 61.5%). The liver was the most common localization of the cysts (302/366, 82.5%). Ninety-eight patients (26.8%) presented complications, including biliary fistula, allergies, and infection of the cyst. Patients with complications had a longer mean hospital stay (15.7 ± 8.3 days) compared to patients without complications (11.5 ± 7.3 days) (p < 0.001). The results of this study revealed that patients diagnosed with CE required hospitalization and extended medical care, indicating that this zoonotic disease remains a significant public health problem in Western Romania. Public health authorities should enhance CE surveillance by implementing control programs and mandatory notification of new cases. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Marine Bioprospecting for the Treatment of Human Parasitic Diseases
- Author
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Khare, Noopur, Mathur, Runjhun, Jha, Niraj Kumar, Taneja, Pankaj, Jha, Saurabh Kumar, Jha, Abhimanyu Kumar, Singh, Archana, editor, Rathi, Brijesh, editor, Verma, Anita K., editor, and Singh, Indrakant K., editor
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- 2023
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22. Nanomaterials in Animal Nutrition and Disease Treatment: Recent Developments and Future Aspects
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Bhagat, Stuti, Mehta, Divya, Singh, Sanjay, Singh, Dheeraj Kumar, editor, Singh, Sanjay, editor, and Singh, Prabhakar, editor
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- 2023
- Full Text
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23. Parasitic Granulomatous Dermatitis Caused by Pelodera spp. in Buffalo on Marajó Island, Pará
- Author
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Camila Cordeiro Barbosa, Carlos Eduardo da Silva Ferreira Filho, Carlos Magno Chaves Oliveira, Tatiane Teles Albernaz Ferreira, Marilene de Farias Brito, Stella Maris Pereira de Melo, Milena Carolina Paz, Saulo Petinatti Pavarini, David Driemeier, and José Diomedes Barbosa
- Subjects
parasitic disease ,rhabditoid nematodes ,Bubalus bubalis ,Amazon biome ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
This is the first report of parasitic granulomatous dermatitis caused by Pelodera spp. in a buffalo. The affected buffalo was about seven years old, was a female of the Murrah breed and belonged to a property located on Marajó Island in the State of Pará. During the clinical examination, the animal was in a standing position and presented several multifocal nodular and placoid masses throughout the body, mostly on the forelimbs, hindlimbs, abdomen, mammary glands, perineum, vulva and tail. These masses were also observed on the nasal mucosa, head, neck, back and chest. On macroscopic examination, the skin had several multifocal-to-coalescent sessile nodular and placoid lesions. Histopathology of the skin showed a marked reduction in the number of hair follicles. In the superficial dermis, there was significant multifocal-to-coalescent inflammatory infiltration, consisting of macrophages, epithelioid macrophages, lymphocytes, plasma cells and multinucleated giant cells. In the remaining hair follicles, there were numerous cross and longitudinal sections of small rhabditoid nematodes characterized by a thin cuticle, platymyarian musculature, an intestinal tract, a rhabditiform esophagus and lateral alae (morphologically compatible with Pelodera spp.). The diagnosis of parasitic dermatitis was confirmed by histopathological skin lesions associated with the presence of intralesional rhabditiform larvae morphologically compatible with Pelodera spp.
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- 2024
- Full Text
- View/download PDF
24. The Body of the Nile: Environmental Disease in the Long Twentieth Century
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Derr, Jennifer L. and Baron, Beth, book editor
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- 2024
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25. Assessment of Knowledge, Attitudes, and Practices Relating to Parasitic Diseases among Pet Owners in Hamadan and Kermanshah, Iran, From 2018 to 2020
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Zainab Sadeghi dehkordi, Roshan Haseli, Babak Moeini, and Alireza Sazmand
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attitude ,hamadan ,kermanshah ,knowledge ,parasitic disease ,performance ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction: Keeping pets can expose their owners to various infections, including zoonotic parasites. This study was conducted for the first time in Iran to assess the knowledge, attitudes, and practices relating to parasitic diseases among pet owners in Hamadan and Kermanshah, Iran. Material & Methods: This descriptive-analytical study was conducted with the participation of 200 pet owners in Hamadan and Kermanshah, western Iran. The data were collected using a researcher-made questionnaire containing 62 questions, the reliability and validity of which were evaluated and confirmed. The obtained data were analyzed in SPSS software (version 19) through descriptive statistics (mean±SD) and inferential statistics (Mann-Whitney test). Findings: Most of the participants were female, had university degrees, and kept dogs. There was a statistically significant difference among the participants of both cities in terms of knowledge about parasitic diseases (it was more in Kermanshah, P
- Published
- 2023
26. Identification and coregulation pattern analysis of long noncoding RNAs in the mouse brain after Angiostrongylus cantonensis infection
- Author
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Cheng, Dong-Hui, Jiang, Tian-Ge, Zeng, Wen-Bo, Li, Tian-Mei, Jing, Yi-Dan, Li, Zhong-Qiu, Guo, Yun-Hai, and Zhang, Yi
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- 2024
- Full Text
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27. The current status and outlook for insecticide, acaricide and anthelmintic resistances across the Australian ruminant livestock industries: assessing the threat these resistances pose to the livestock sector.
- Author
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Kotze, AC and Hunt, PW
- Subjects
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ANTHELMINTICS , *ANIMAL industry , *ACARICIDES , *RUMINANTS , *CHEMICAL resistance , *INSECTICIDES , *PARASITIC diseases - Abstract
The Australian ruminant livestock industries are faced with the need to control parasitic infectious diseases that can seriously impact the health of animals. However, increasing levels of resistance to insecticides, anthelmintics and acaricides are substantially reducing the ability to control some of these parasites. Here we review the current situation with regard to chemical resistances in parasites across the various sectors of the Australian ruminant livestock industries and assess the level of threat that these resistances pose to the sustainability of these sectors in the short to long terms. We also look at the extent to which testing for resistance occurs across the various industry sectors, and hence how well‐informed these sectors are of the extent of chemical resistance. We examine on‐farm management practices, breeding of parasite‐resistant animals, and non‐chemical therapeutics that may act as short to long term means to reduce the current reliance on chemicals for parasite control. Finally, we look at the balance between the prevalence and magnitude of current resistances and the availability and adoption rates of management, breeding and therapeutic alternatives in order to assess the parasite control outlook for the various industry sectors. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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28. Investigation of Proliferative Kidney Disease in Brown Trout and Habitat Characteristics Associated with a Swiss Wastewater Treatment Plant.
- Author
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Saura Martinez, Helena, Egloff, Nicole, and Schmidt-Posthaus, Heike
- Subjects
BROWN trout ,SEWAGE disposal plants ,KIDNEY diseases ,SEWAGE ,INDUSTRIAL wastes - Abstract
Wastewater treatment plants (WWTP) play a critical role in mitigating adverse environmental impacts of urban and industrial wastewater by removing pollutants and reducing the risk of contamination. Discharges of treated effluents from WWTPs can still have significant effects on freshwater ecosystems, particularly on sensitive species like brown trout. We analyzed the effects of a modern WWTP on a freshwater ecosystem, studying fish biodiversity and biomass, the occurrence of the parasitic disease Proliferative Kidney Disease (PKD) on brown trout, river water temperatures throughout the year and fish habitat and diversity. No major differences between up- and downstream of the WWTP were observed in habitat structure and attractiveness, fish biomass and species diversity, nor in PKD prevalence or intermediate host presence. However, immediately at the WWTP's effluent and continuing downstream, the water temperature rose by almost 1 °C. While WWTPs are crucial for reducing the environmental impact of urban and industrial wastewater, their effluents can still have important consequences for freshwater ecosystems. Brown trout are particularly susceptible to increases in water temperature, especially regarding PKD severity and consequent mortality. To ensure the long-term health and sustainability of freshwater ecosystems, it is imperative to improve measures to minimize water temperature rises and mitigate downstream cascade effects on sensitive organisms like brown trout. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
29. Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities.
- Author
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Porta, Exequiel O. J., Kalesh, Karunakaran, and Steel, Patrick G.
- Subjects
CHAGAS' disease ,DRUG repositioning ,DRUG discovery ,COMBINATION drug therapy ,ANTIPARASITIC agents ,THERAPEUTICS - Abstract
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America. Currently, there is no available vaccine, and chemotherapy has been the traditional treatment for Chagas disease. However, the treatment options are limited to just two outdated medicines, nifurtimox and benznidazole, which have serious side effects and low efficacy, especially during the chronic phase of the disease. Collectively, this has led the World Health Organization to classify it as a neglected disease. To address this problem, new drug regimens are urgently needed. Drug repurposing, which involves the use of existing drugs already approved for the treatment of other diseases, represents an increasingly important option. This approach offers potential cost reduction in new drug discovery processes and can address pharmaceutical bottlenecks in the development of drugs for Chagas disease. In this review, we discuss the state-of-the-art of drug repurposing approaches, including combination therapy with existing drugs, to overcome the formidable challenges associated with treating Chagas disease. Organized by original therapeutic area, we describe significant recent advances, as well as the challenges in this field. In particular, we identify candidates that exhibit potential for heightened efficacy and reduced toxicity profiles with the ultimate objective of accelerating the development of new, safe, and effective treatments for Chagas disease. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
30. Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery.
- Author
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Bedogni, Giselle, Garcia, Paula, Seremeta, Katia, Okulik, Nora, and Salomon, Claudio
- Subjects
- *
PRAZIQUANTEL , *CHILD patients , *NEUROCYSTICERCOSIS , *CYSTICERCOSIS , *DESMOPRESSIN , *FLAVOR - Abstract
To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients. Praziquantel is a poorly water-soluble drug which represents a challenge for its formulation in solution, particularly for the pediatric population. Thus, this study aimed to develop a palatable solution for praziquantel using pharmaceutical-accepted co-solvent systems. A design of experiments approach was applied to identify the optimal conditions for achieving a suitable amount of praziquantel in solution using co-solvent mixtures. Thus, praziquantel solubility increased from 0.38 up to 43.50 mg/mL in the optimized system. A taste masking assay in healthy human volunteers confirmed a successful reduction of drug bitterness after the addition of selected flavors and a sweetener. Stability studies were also conducted at different temperatures (4, 25, and 40 °C) for 12 months Even though the presence of the three known impurities of praziquantel was observed, their amounts never exceeded the acceptance criteria of the USP. Thus, this novel approach should be considered a valuable alternative for further preclinical studies considering the high prevalence of this infection worldwide. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
31. Chagas Disease Cardiomyopathy.
- Author
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Jimenez, Ariana and Winokur, Elizabeth J.
- Subjects
- *
TREATMENT of cardiomyopathies , *PHYSICAL diagnosis , *AMBULATORY electrocardiography , *MYOCARDIAL depressants , *HEART transplantation , *CHEST X rays , *CARDIOMYOPATHIES , *ANTICOAGULANTS , *IMPLANTABLE cardioverter-defibrillators , *HEART assist devices , *SYMPTOMS , *THROMBOEMBOLISM , *BLOOD testing , *HEART failure , *ABLATION techniques , *INFECTIOUS disease transmission - Abstract
Abstract Chagas disease is a prominent neglected tropical disease endemic to many countries in Latin America. Cardiomyopathy is the most serious manifestation due to the severity and complications of heart failure. As a result of expanded immigration and globalization, there is an increased number of patients with Chagas cardiomyopathy who are being admitted to hospitals in the United States. It is imperative as a critical care nurse to be educated on the nature of Chagas cardiomyopathy as it differs from the more commonly seen ischemic and nonischemic forms. This article provides an overview of the clinical course, management, and treatment options of Chagas cardiomyopathy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
32. Evaluation of hydatid cysts in University of Health Sciences Kartal Kosuyolu Research and Training Hospital.
- Author
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Kaya, Sibel Dogan, Evik, Guliz, Ak, Adnan, Cardak, Murat Ersin, and Aydin, Isa Caner
- Subjects
ECHINOCOCCOSIS ,NEUROCYSTICERCOSIS ,ECHINOCOCCUS granulosus ,PARASITIC diseases ,ANIMAL culture ,ANIMAL health - Abstract
Aim: Hydatic cyst is one of the most common parasitic diseases caused by Echinococcus granulosus. Although it can be seen worldwide, it is a significant health problem in developing countries such as Türkiye. In this study, we reviewed the epidemiological and clinical data of cystic echinococcosis cases in a tertiary hospital and reviewed current trends in the diagnosis and treatment of the disease. Materials and Methods: A total of 41 patients were included in the study between January 1, 2008, and December 31, 2022. Results: In the retrospectively planned study, 16 (39%) of the patients were female, and the mean age was determined to be 47.4±11.7 years. Twenty-seven (65.9%) of the patients were living in rural areas. The most affected organ was the liver (48.8%). Multiple organ involvement was observed in 2 cases. The diagnosis of most patients was made using ultrasound (73.2%). Anemia (22%) was the most frequently detected finding in the laboratory tests performed before treatment. Other laboratory findings were ranked as eosinophilia and leukocytosis. The treatment of the majority of patients was done both medically and surgically (75.6%). Thirty-four patients (82.9%) did not have a recurrence. Among the 7 patients who had a recurrence, the first site of recurrence was observed in the liver in 3 of them. Conclusion: Hydatid cyst is still an important disease in our country due to its impact on both human and animal health and serious economic losses in areas engaged in animal husbandry. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
33. Cystic Echinococcosis in Hospitalized Children from Western Romania: A 25-Year Retrospective Study
- Author
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Ana Alexandra Paduraru, Maria Alina Lupu, Calin Marius Popoiu, Maria Corina Stanciulescu, Livius Tirnea, Eugen Sorin Boia, and Tudor Rares Olariu
- Subjects
hydatidosis ,Echinococcus granulosus ,zoonosis ,parasitic disease ,Romania ,Biology (General) ,QH301-705.5 - Abstract
Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by Echinococcus granulosus. We aimed to assess the epidemiological aspects of the disease in hospitalized children from Western Romania, a well-known endemic area for CE. We retrospectively investigated the medical records of children hospitalized between 1998 and 2022. A total of 144 patients were included, and 58.3% were from rural areas. The number of cases increased with age, from 9% in the age group 3–5 years to 59.7% in the age group 11–17 years. The liver was more frequently affected (65.3%), and a significant association between gender and the affected organ was noted; liver cysts were more frequently diagnosed in girls, while lung cysts were recorded mostly in boys. Complications were more frequently reported in patients with pulmonary CE compared to hepatic CE (p = 0.04). Boys had more complications (16/23, 69.6%) compared to girls (7/23, 30.4%) (p = 0.03). A third of the children were hospitalized for more than 14 days, and multiple hospitalizations were recorded in 31.3% of the patients. This paper provides new insights into the epidemiologic features of cystic echinococcosis in children from Western Romania. Our findings indicate that exposure to the parasite starts in childhood, and the rate of hospitalization increases with age. Public health strategies should be implemented and permanently improved in order to lower the prevalence of CE in children.
- Published
- 2024
- Full Text
- View/download PDF
34. Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites
- Author
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SGS Life Sciences, a division of SGS Belgium NV, Institute of Tropical Medicine, Belgium, Swiss BioQuant A.G., Switzerland, PrimeVigilance Ltd., UK, Sanaria Inc., Iqvia Pty Ltd, and FGK Representative Service B.V., The Netherlands
- Published
- 2021
35. A Disseminated Echinococcosis Patient with Five Years Survival from Turkey: A Case Report.
- Author
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Karakök, Taliha, Ata, Nesrin, Kiliç, Esra Kaya, and Kinikli, Sami
- Subjects
- *
ECHINOCOCCOSIS , *PARASITIC diseases , *PAROTID glands , *THYROID gland , *MEDIASTINUM , *KIDNEYS , *BREAST - Abstract
Echinococcosis is a parasitic disease characterized by cysts in especially liver and lung. We report a long-term survival of a 44-year-old female patient with disseminated echinococcal disease involving the brain, lung, liver, spleen, kidney, mediastinum, thyroid gland, parotid gland, pancreas, peritoneum, rectus muscle, pararenal area, left thigh, skin and breast tissue from Turkey in 2016. [ABSTRACT FROM AUTHOR]
- Published
- 2023
36. Parasitic Diseases
- Author
-
Ogawa, Marilia Marufuji, de Castro Lima Santos, Daniel Wagner, Tomimori, Jane, editor, Oliveira, Walmar Roncalli Pereira de, editor, Ferrándiz-Pulido, Carla, editor, and Ogawa, Marilia Marufuji, editor
- Published
- 2022
- Full Text
- View/download PDF
37. Compassionate Use of Triclabendazole for the Treatment of Parasites (Prior to FDA Approval; Expanded Access Program)
- Published
- 2021
38. Immunomodulating and Anti-parasitary Mechanisms of Plant Products in the Treatment of Schistosomiasis
- Author
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Lira, Maria Gabriela Sampaio, Nogueira, Ranielly Araujo, Licá, Irlla Correia Lima, Frazão, Gleycka Cristine Carvalho Gomes, dos Santos, Vitor Augusto Ferreira, Mendes, Antonio Camilo Correia, Rodrigues, João Gustavo Mendes, Miranda, Guilherme Silva, Silva, Lucilene Amorim, Guerra, Rosane Nassar Meireles, Carvalho, Rafael Cardoso, and Nascimento, Flávia Raquel Fernandes
- Published
- 2023
- Full Text
- View/download PDF
39. ارزیابی آگاهی، نگرش و عملکرد صاحبان حیوانات خانگی در رابطه با بیماریهای انگلی در شهرهای همدان و کرمانشاه در سالهای ۱۳۹۷ و ۱۳۹8.
- Author
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زینب صادقی دهکرد, روشن حاصلی, بابک معینی, and علیرضا سازمند
- Subjects
RESEARCH ,STATISTICS ,ATTITUDE (Psychology) ,RESEARCH methodology ,PETS ,ZOONOSES ,HEALTH literacy ,HUMAN-animal relationships ,PARASITIC diseases ,DESCRIPTIVE statistics ,DATA analysis software ,DATA analysis - Abstract
Introduction: Keeping pets can expose their owners to various infections, including zoonotic parasites. This study was conducted for the first time in Iran to assess the knowledge, attitudes, and practices relating to parasitic diseases among pet owners in Hamadan and Kermanshah, Iran. Material & Methods: This descriptive-analytical study was conducted with the participation of 200 pet owners in Hamadan and Kermanshah, western Iran. The data were collected using a researcher-made questionnaire containing 62 questions, the reliability and validity of which were evaluated and confirmed. The obtained data were analyzed in SPSS software (version 19) through descriptive statistics (mean±SD) and inferential statistics (Mann-Whitney test). Findings: Most of the participants were female, had university degrees, and kept dogs. There was a statistically significant difference among the participants of both cities in terms of knowledge about parasitic diseases (it was more in Kermanshah, P<0.01); however, no statistical difference was observed in terms of attitude. Spearman's correlation coefficient showed that in Hamadan and Kermanshah, there is a direct and significant relationship between the knowledge score and performance (Hamadan: r=0.489 and P<0.001; Kermanshah: r=0.655 and P<0.001). In general, the level of knowledge and performance of pet owners is at an unfavorable level, and their attitude is at a favorable level. Discussion & Conclusion: This study, which was conducted for the first time in Iran, suggests that pet owners need necessary training to increase their level of knowledge about parasites and parasitic diseases of their animals, which will lead to improving their attitude and performance. [ABSTRACT FROM AUTHOR]
- Published
- 2023
40. Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland.
- Author
-
Stefaniak, Magdalena, Derda, Monika, Zmora, Pawel, and Nowak, Szymon Pawel
- Subjects
ECHINOCOCCUS multilocularis ,EARLY diagnosis ,ZOONOSES ,LIVESTOCK breeds ,PARASITIC diseases - Abstract
Alveolar echinococcosis (AE) is a chronic zoonotic disease caused by the larval form of Echinococcus multilocularis. In humans, it may become a serious chronic infection of the liver which resembles a slow malignant process leading to death when untreated. The aim of the study was an assessment of the risk factors of the E. multilocularis infections and the description of AE clinical course in the group of 36 patients with confirmed AE, hospitalized at the Department and Clinic of Tropical and Parasitic Diseases, Poznan University of Medical Sciences between 2013 and 2022. Among the study participants, most patients cultivated land, bred livestock, worked in the forest, or were employed in animal shelters. The E. multilocularis infection was diagnosed based on imaging and immunoassay techniques within 6 months in the majority of patients hospitalized in the Department. All patients hospitalized in the Department initiated anti-parasitic therapy at the moment of the diagnosis. Pharmacological treatment combined with surgery was applied in most of the study participants, who were presented with more advanced stages of infection. We conclude the following: 1. For humans in the risk group, regular abdominal imaging examinations and the detection of specific antibodies against E. multilocularis are recommended. 2. Regular screening tests in the hyperendemic areas of AE would increase the early detection of the disease and to improve the clinical prognosis in this extremely life-threatening parasitic disease. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
41. A Disseminated Echinococcosis Patient with Five Years Survival from Turkey: A Case Report
- Author
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Taliha Karakök, Nesrin Ata, Esra Kaya Kiliç, and Sami Kinikli
- Subjects
Echinococcus ,dissemination ,parasitic disease ,cyst hydatid ,Infectious and parasitic diseases ,RC109-216 - Abstract
Echinococcosis is a parasitic disease characterized by cysts in especially liver and lung. We report a long-term survival of a 44-year-old female patient with disseminated echinococcal disease involving the brain, lung, liver, spleen, kidney, mediastinum, thyroid gland, parotid gland, pancreas, peritoneum, rectus muscle, pararenal area, left thigh, skin and breast tissue from Turkey in 2016.
- Published
- 2023
- Full Text
- View/download PDF
42. Co-infection of COVID-19 and parasitic diseases: A systematic review
- Author
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Fatemeh Nemati Zargaran, Mosayeb Rostamian, Sara Kooti, Hamid Madanchi, and Keyghobad Ghadiri
- Subjects
Co-infection ,COVID-19 ,Parasite ,Parasitic disease ,Systematic review ,Infectious and parasitic diseases ,RC109-216 - Abstract
Co-infection of COVID-19 with other diseases increases the challenges related to its treatment management. COVID-19 co-infection with parasites is studied with low frequency. Here, we systematically reviewed the cases of parasitic disease co-infection with COVID-19. All articles on COVID-19 co-infected with parasites (protozoa, helminths, and ectoparasites), were screened through defined inclusion/exclusion criteria.Of 2190 records, 35 studies remained for data extraction. The majority of studies were about COVID-19 co-infected with malaria, followed by strongyloidiasis, amoebiasis, chagas, filariasis, giardiasis, leishmaniasis, lophomoniasis, myiasis, and toxoplasmosis. No or low manifestation differences were reported between the co-infected cases and naïve COVID-19 or naïve parasitic disease.Although there was a relatively low number of reports on parasitic diseases-COVID-19 co-infection, COVID-19 and some parasitic diseases have overlapping symptoms and also COVID-19 conditions and treatment regimens may cause some parasites re-emergence, relapse, or re-activation. Therefore, more attention should be paid to the on-time diagnosis of COVID-19 and the co-infected parasites.
- Published
- 2023
- Full Text
- View/download PDF
43. Enterobius Vermicularis Infestation of the Appendix
- Author
-
Aabdulkarim Hasan, Lab Director
- Published
- 2020
44. First Identification of Trichinella pseudospiralis in a Golden Jackal (Canis aureus) in Romania
- Author
-
Ana-Maria Marin, Dan-Cornel Popovici, Gianluca Marucci, Simona Cherchi, and Narcisa Mederle
- Subjects
trichinellosis ,parasitic disease ,zoonosis ,Medicine - Abstract
Trichinella spp. are etiological zoonotic agents that spread throughout the world and affect mammals, birds, and reptiles. Within this genus, Trichinella pseudospiralis is the only recognized non-encapsulated species known to infect mammals and birds. This species has been reported in the majority of European countries, and the real epidemiological scenario of this species remains to be defined because its detection in mammals is much lower than that of the capsulated species. The aim of this study was to examine the presence of Trichinella larvae isolated from the muscles of a jackal from the hunting fund of 36 Murfatlar, Constanta County, Romania. The muscle samples were examined by artificial digestion, and the larvae were identified at the species level by multiplex PCR. The presence of larvae belonging to T. pseudospiralis, a species more frequently reported in carnivorous birds, was observed. This study describes the first identification of T. pseudospiralis in a jackal. The results suggest that there is an urgent need to investigate which species of mammals and/or birds act as reservoirs for this zoonotic nematode in Romania.
- Published
- 2023
- Full Text
- View/download PDF
45. 临沂市奶牛主要寄生虫病的流行 现状与对策.
- Author
-
赵加军
- Abstract
Copyright of China Dairy is the property of China Dairy Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
46. Application of Medicinal Plants in Treatment of Leishmaniasis: A Scoping Review Study
- Author
-
Mohammad Taghi Ahady, Fatemeh Fahimi, and Maedeh Naghizadeh
- Subjects
protozoan infection ,leishmaniasis ,medicinal plants ,parasitic disease ,natural medicines ,Medicine ,Medicine (General) ,R5-920 - Abstract
Parasitic diseases, including leishmaniasis, are the most prevalent infections worldwide that have serious risks for human health. Due to the serious side effects of chemical drugs and their inefficiency in some cases, medicinal plants have recently been considered for treating parasitic diseases. This scoping review study aimed to investigate and identify the medicinal plants introduced to treat leishmaniasis throughout the world. Scientific websites, including Google Scholar, PubMed, Magiran, Web of Science, and Elsevier were used to collect scientific information and research papers. The used keywords are Leishmaniasis, Medicinal Plants, and Protozoal Infection. The data were extracted and collected using research papers published over the past 16 years (2006-2022). Forty-three papers from the overall 385 collected articles were selected for the present study because of their complete relationship with the main aim of the research. The selected articles investigated 32 plant species for the treatment of leishmaniasis. The results of this systematic review study confirmed the therapeutic effect of 32 different kinds of medicinal plants. Furthermore, among these plants, three had stronger therapeutic effects and fewer side effects, including Rosmarinus Officinalis, Aloe otallensis, and Cephalis ipecacuana.
- Published
- 2022
- Full Text
- View/download PDF
47. What Findings on Chest CTs Can Delay Diagnosis of Pleuropulmonary Paragonimiasis?
- Author
-
Kai Ke Li, Gong Yong Jin, and Keun Sang Kwon
- Subjects
parasitic disease ,paragonimiasis ,lung ,computed tomography (CT) ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Purpose: The purpose of this study was to investigate which findings were delayed in diagnosis with respect to chest CT findings of paragonimiasis. Methods: This retrospective, informed questionnaire study was conducted to evaluate chest CT scans of 103 patients (58 men and 45 women; mean age 46.1 ± 14.6 years). The patients were diagnosed with paragonimiasis from 2003 to 2008 in four tertiary hospitals. Statistical analysis was performed using the chi-square test to identify differences between an initially correct diagnosis and an incorrect one of paragonimiasis on chest CT scans, for which we evaluated such variables as the location of lesion, type of parenchymal lesions, and worm migration track. Results: Nodular opacities on chest CT scans were the most common findings (53/94, 56.4%). The sign of worm migration tracks was only present in 18.1% of cases (17/94). Although statistically insignificant, the form of consolidation (18/25, 72%) and mass (6/8, 75%) on CT was common in correct diagnostics, and the form of the worm migration track (12/17, 70.6%) was high in correct diagnostics. Conclusion: A delayed diagnosis of paragonimiasis may often be made in patients with non-nodular, parenchymal lesions who are negative for worm migration track on chest CT scans.
- Published
- 2022
- Full Text
- View/download PDF
48. Surgical treatment of a patient with live intracranial sparganosis for 17 years
- Author
-
Jialing Hu, Kaili Liao, Xiaojin Feng, Danling Jiang, Hailin Liu, Qingcui Zheng, Hai Qiu, Fuzhou Hua, Guohai Xu, and Chunhua Xu
- Subjects
Sparganosis mansoni ,Intracranial infection ,Parasitic disease ,Neuronavigation ,Case report ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The incidence of sparganosis, especially intracranial live sparganosis is very low in China. Due to the lack of typical clinical manifestations, it is difficult to make a clear preoperative diagnosis of the disease, which often leads to delays the disease and serious consequences. Case presentation A 23-year-old man presented with a 17-year history of intermittent seizures and right extremity numbness and weakness. Magnetic resonance imaging (MRI) showed patchy, nodular and line-like enhancement. Enzyme-linked immunosorbent assay (ELISA) detected positive antibodies to Spirometra mansoni in peripheral blood and cerebrospinal fluid (CSF). In addition, during the operation, an ivory-colored live sparganosis was removed under the precise positioning of neuronavigation, and the patient was diagnosed with cerebral sparganosis. The patient began praziquantel and sodium valproate treatment after the operation, and was followed up for 3 months. There was no recurrence of epilepsy, and the weakness and numbness of the right limb improved. Conclusion Nonspecific clinical manifestations often make the diagnosis of cerebral sparganosis difficult, and a comprehensive diagnosis should be made based on epidemiological history, clinical manifestations, ELISA results and imaging findings. Surgery is the preferred method for the treatment of cerebral sparganosis, and more satisfactory results can be achieved under the precise positioning of neuronavigation.
- Published
- 2022
- Full Text
- View/download PDF
49. Frequency of Parasite Infestation in Patients With Chronic Spontaneous Urticaria
- Published
- 2020
50. To intervene or not to intervene: A case of symptomatic neurocysticercosis complicated by ventriculitis
- Author
-
Syed H. Haq, Sidra R. Shah, Jannet Bux, Anh Si Le, Hafez Golzarian, Daniel Mueller, Joseph J. Sreenan, Sandeep M. Patel, Amanda Laird, and William Cole
- Subjects
Neurocysticercosis ,Parasitic disease ,Taenia solium ,Ventriculitis ,Cyst ,Ring-enhancing lesions ,Infectious and parasitic diseases ,RC109-216 - Abstract
Although well described in the current literature, Neurocysticercosis [NCC] remains an enigma when confronted by practitioners. This is in part due to the haphazard nature of the parasitic infection on the central nervous system [CNS]. These include single or multiple anatomic sites of infection, stage of parasitosis, and the resultant inflammatory response. As a result, NCC can present with a complex constellation of symptomatic presentations, making therapeutic regiments highly individualized. Despite intervention, other impediments may arise post-therapy due to the nature of the infection. We present a case of rapidly progressive symptomatic NCC that initially was successfully treated, however would eventually succumb to complications of ventriculitis.
- Published
- 2023
- Full Text
- View/download PDF
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