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50 results on '"Parashar, Gaurav"'

2. Exploring Risk Factors for Cardiovascular Disease: Insights from NHANES Database Analysis

Author

Parashar, Gaurav, Chaudhary, Alka, Pandey, Dilkeshwar, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Tiwari, Shailesh, editor, Trivedi, Munesh C., editor, Kolhe, Mohan L., editor, and Singh, Brajesh Kumar, editor

Published
2024
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20. Intralesional sclerotherapy with bleomycin in lymphatic malformation of tongue an institutional experience and outcomes

Author

Parashar, Gaurav, Shankar, Gowri, Sahadev, Ravindra, and Santhanakrishnan, Ramesh

Subjects
Antineoplastic agents, Molecular genetics, Disabilities, Health
Abstract

Byline: Gaurav. Parashar, Gowri. Shankar, Ravindra. Sahadev, Ramesh. Santhanakrishnan Introduction: The management of lymphatic malformations (LMs) continues to improve with advancement in molecular genetics, imaging, and treatment options. However, the [...]

Published
2020

23. Pollution Study Of Near By River (Nag River)

Author

Rahangdale, Kushal, primary, Khaire, Joshua, additional, Bhoyar, Vasundhara, additional, Patil, Himani, additional, Thakre, Gajendra, additional, Bawane, Yugandhara, additional, Parashar, Gaurav, additional, and Kamble, Shubham, additional

Published
2022
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24. Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential

Author

Tuli, Hardeep S., primary, Aggarwal, Vaishali, additional, Parashar, Gaurav, additional, Aggarwal, Diwakar, additional, Parashar, Nidarshana C., additional, Tuorkey, Muobarak J., additional, Varol, Mehmet, additional, Sak, Katrin, additional, Kumar, Manoj, additional, and Buttar, Harpal S., additional

Published
2022
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29. Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance

Author

Tuli, Hardeep Singh, primary, Mittal, Sonam, additional, Aggarwal, Diwakar, additional, Parashar, Gaurav, additional, Parashar, Nidarshana Chaturvedi, additional, Upadhyay, Sushil Kumar, additional, Barwal, Tushar Singh, additional, Jain, Aklank, additional, Kaur, Ginpreet, additional, Savla, Raj, additional, Sak, Katrin, additional, Kumar, Manoj, additional, Varol, Mehmet, additional, Iqubal, Ashif, additional, and Sharma, Anil Kumar, additional

Published
2021
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36. COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

Author

Chakrabarti, Sankha Shubhra, primary, Kaur, Upinder, primary, Banerjee, Anindita, primary, Ganguly, Upasana, primary, Banerjee, Tuhina, primary, Saha, Sarama, primary, Parashar, Gaurav, primary, Prasad, Suvarna, primary, Chakrabarti, Suddhachitta, primary, Mittal, Amit, primary, Agrawal, Bimal Kumar, primary, Rawal, Ravindra Kumar, primary, Zhao, Robert Chunhua, primary, Gambhir, Indrajeet Singh, primary, Khanna, Rahul, primary, Shetty, Ashok K, primary, Jin, Kunlin, primary, and Chakrabarti, Sasanka, primary

Published
2020
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38. – (-) Menthol Induces Reversal of Promoter Hypermethylation and Associated Up-Regulation of the FANCF Gene in the SiHa Cell Line

Author

Parashar, Gaurav, Parashar, Nidarshana Chaturvedi, and Capalash, Neena

Subjects
re expression, cervical cancer, (-) Menthol, promoter hypomethylation, FANCF, EGCG, Research Article
Abstract

Objective: To identify natural bioactive molecules with potential to inhibit DNA methyltransferase 1 (DNMT1) and cause reactivation of genes silenced due to promoter hypermethylation. Methods and Results: -(-) Menthol and epigallocatechin-3-gallate (EGCG) (reference molecule) were investigated using an in vitro methylation assay, which indicated potential of -(-) menthol as an epigenetic modulator with the ability to directly inhibit M.SssI (an analogue of DNMT1) activity at 100µM. Methylation specific PCR and bisulphite sequencing revealed complete hypomethylation of 15 CpG sites in the Fanconi anemia, complementation group F (FANCF) gene between +280 and + 432 nucleotides relative to the transcription start site, which resulted in significant (P

Published
2017

42. Kaposiform Hemangioendothelioma with Kasabach-Merritt Phenomenon in a Neonate - Role of Dual Therapy: A Case Report and Review of Literature.

Author

Parashar, Gaurav, Shankar, Gowri, Sahadev, Ravindra, and Santhanakrishnan, Ramesh

Subjects
*STEROID drugs, *BLOOD-vessel tumors, *DISEASES, *HEMANGIOMAS, *MEDICAL protocols, *VINCRISTINE, *DECISION making in clinical medicine, *TREATMENT effectiveness, *KASABACH-Merritt syndrome, *DISEASE complications
Abstract

Kaposiform hemangioendothelioma (KHE) represents a rare, borderline vascular tumor with locally aggressive behavior. They are often associated with a potentially life-threatening coagulopathy known as Kasabach-Merritt phenomenon (KMP). Due to heterogeneous nature of the vascular lesion and lack of standardized treatment protocols, these patients pose a diagnostic dilemma and therapeutic challenge with morbidity and potential mortality. We report successful management of an infant with KHE and associated KMP. Difficulties encountered in diagnosis, initiation of therapy, and role of dual therapy with vincristine and steroids are discussed. [ABSTRACT FROM AUTHOR]

Published
2020
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46. N6-adenine DNA methylation demystified in eukaryotic genome: From biology to pathology.

Author

Parashar, Nidarshana Chaturvedi, Parashar, Gaurav, Nayyar, Harsh, and Sandhir, Rajat

Subjects
*DNA methylation, *EUKARYOTIC genomes, *DEOXYADENOSINE, *PROKARYOTES, *CHROMATIN
Abstract

N 6 -methyl-2′-deoxyadenosine (m6dA) is a well characterized DNA modification in prokaryotes. Its existence in eukaryotic DNA remained doubtful until recently. Evidence suggests that the m6dA levels decrease with the increasing complexity of eukaryotic genomes. Analysis of m6dA levels in genome of lower eukaryotes reveals its role in gene regulation, nucleosome positioning and early development. In higher eukaryotes m6dA is enriched in nongenic region compared to genic region, preferentially in chromosome X and 13 suggesting a chromosome bias. High levels of m6dA during embryogenesis as compared to adult tissues are indicative of its importance during development and possible association with regeneration capabilities. Further, decreased levels of m6dA in diabetic patients has been correlated with expression of Fat mass and obesity-associated (FTO) which acts as m6A demethylase. m6dA levels have also been reported to be decreased in different types of cancers. The present review highlights the role of m6dA modification in eukaryotic genomes and its functional importance in regulation of physiological and pathological processes. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targets.

Author

Tuli HS, Sak K, Adhikary S, Kaur G, Aggarwal D, Kaur J, Kumar M, Parashar NC, Parashar G, Sharma U, and Jain A

Subjects
Anti-Inflammatory Agents pharmacology, Antioxidants pharmacology, Apoptosis, Flavonoids pharmacology, Flavonoids therapeutic use
Abstract

With the dramatic increase in cancer incidence all over the world in the last decades, studies on identifying novel efficient anti-cancer agents have been intensified. Historically, natural products have represented one of the most important sources of new lead compounds with a wide range of biological activities. In this article, the multifaceted anti-cancer action of propolis-derived flavonoid, galangin, is presented, discussing its antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, anti-angiogenic, and anti-metastatic effects in various cancer cells. In addition, co-effects with standard chemotherapeutic drugs as well as other natural compounds are also under discussion, besides highlighting modern nanotechnological advancements for overcoming the low bioavailability issue characteristic of galangin. Although further studies are needed for confirming the anti-cancer potential of galangin in vivo malignant systems, exploring this natural compound might open new perspectives in molecular oncology.

Published
2022
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