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Aims and Objective: The aim of this study was to evaluate the bacterial profile in root canals of human permanent teeth with necrotic pulp and periapical lesions using microbiological culture techniques to find out the prevalence of various species of microorganisms in these lesions. Materials and Methods: A 40 root canals of human permanent teeth with necrotic pulp and periapical lesions were examined using bacterial culture. After gaining access to the pulpal tissue, the material was collected using files/broaches for microbiological evaluation and determination of colony forming units. Results: Anaerobic microorganisms were found in 95% of the samples, black-pigmented bacilli in 37.5%, aerobic microorganisms in 92.5%, streptococci in 95%, and Streptococcus mutans in 45%. Conclusion: An infected pulpal tissue of the permanent teeth pulpal and periapical pathologies contain a high number of polymicrobial organisms with the high prevalence of anaerobic Bacteria and Streptococci species. [ABSTRACT FROM AUTHOR]

Background: Prevention and management of post-operative endodontic pain is an integral part of endodontic treatment as it increases the patient's comfort, confidence, and improves the outcome of the endodontic therapy. Materials and Methods: A total of 75 patients were included in the study. Their consent was taken, and 200 mg of ibuprofen, 20 mg of tenoxicam, or 10 mg of ketorolac before root canal treatment was given orally. Visual analogue scale was used to measure postoperative pain. The pain was measured at intervals of 0, 6, 12, 24, 48, and 72 h after treatment was started. Results: All the three drugs reduced the post-treatment pain to approximately similar levels at different time lags other than 6 h interval. Conclusion: The three drugs were approximately equally effective in controlling the pain. Further research with the higher study group and more parameters is required tofind out the efficacy of various analgesics. [ABSTRACT FROM AUTHOR]