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4. Cardiac Sarcoma Mimicking Libman–Sacks Endocarditis in a Patient with Systemic Lupus Erythematosus (SLE): A Case Report and Literature Review.

Author

Ritter, Einat, Itach, Tamar, Paran, Daphna, Gaskin, Aleksandr, Havakuk, Ofer, and Ablin, Jacob Nadav

Subjects
PROSTHETIC heart valves, MITRAL valve insufficiency, MITRAL valve, SYSTEMIC lupus erythematosus, LITERATURE reviews
Abstract

We present the case of a 39-year-old woman who was diagnosed with SLE and antiphospholipid antibodies 8 years ago. The chief manifestations of her disease included low-grade fever and polyarthritis. Eight months before presentation, she experienced symptoms attributed to a flare of SLE, leading to an increase in immunomodulatory treatment with no improvement. She presented to the emergency room with acute onset of dyspnea. Clubbing of her fingers and toes was noted. When questioned, she reported the onset of clubbing 5 months earlier. A CTA was performed to rule out pulmonary embolism, which was excluded, although it revealed a severely damaged mitral valve with severe insufficiency and a large mass on the valve, protruding into the left atrium. Antibiotics were started, with a working diagnosis of infectious endocarditis; however, the severe mitral valve dysfunction lead to emergency mitral valve replacement, revealing an organized thrombus. She was treated with anticoagulation, with a working diagnosis of Libman–Sacks endocarditis, with no improvement. Additional immunosuppression failed to improve her symptoms. Enlargement of the thrombotic mass and an increased gradient across the prosthetic mitral valve led to repeat surgery, culminating in a diagnosis of high-grade sarcoma within the left atrial mass. We further discuss cardiac sarcoma and describe the occurrence of clubbing in patients with sarcoma. This case highlights the importance of interdisciplinary collaboration and the need for vigilant monitoring in refractory cases, particularly when atypical presentations arise. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Effect of Secukinumab and Tumor Necrosis Factor Inhibitors on Humoral Response to BNT162b2 mRNA Vaccine in Patients With Spondyloarthritis Compared to Immunocompetent Controls

Author

Eviatar, Tali, primary, Furer, Victoria, additional, Polachek, Ari, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Elalouf, Ofir, additional, Levartovsky, David, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Haddad, Amir, additional, Feld, Joy, additional, Aassi, Maher, additional, Quebe-Fehling, Erhard, additional, Alarcon, Ivette, additional, Pel, Sara, additional, Paran, Daphna, additional, and Elkayam, Ori, additional

Published
2023
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7. The association between sonographic enthesitis with sonographic synovitis and tenosynovitis in psoriatic arthritis patients.

Author

Balulu, Gavriel, Furer, Victoria, Wollman, Jonathan, Levartovsky, David, Aloush, Valerie, Elalouf, Ofir, Sarbagil-Maman, Hagit, Mendel, Liran, Borok, Sara, Paran, Daphna, Elkayam, Ori, and Polachek, Ari

Subjects
PSORIATIC arthritis, TENOSYNOVITIS, TENDON injuries, SYNOVITIS, MULTIVARIATE analysis, AGE distribution, INFLAMMATION, REGRESSION analysis, SEX distribution, DESCRIPTIVE statistics, DOPPLER ultrasonography, ARTHRITIS, LONGITUDINAL method
Abstract

Objectives To examine the association between sonographic enthesitis with sonographic synovitis and tenosynovitis in PsA patients, and the association between sonographic enthesitis and clinical characteristics. Methods Consecutive PsA patients that fulfilled the ClASsification criteria for Psoriatic ARthritis (CASPAR) were prospectively recruited. Each patient was evaluated by comprehensive clinical and sonographic assessment (greyscale and Doppler), the latter including 52 joints, 40 tendons and 14 entheses [according to MAdrid Sonography Enthesitis Index (MASEI) plus lateral epicondyles] performed by an experienced sonographer blinded to the clinical data. The US enthesitis score was further categorized to inflammatory (hypoechogenicity, thickening, bursitis and Doppler) and structural (enthesophytes/calcifications and erosions) subcategories. Multivariate linear regression models assessed the association between enthesitis and the selected variables. Results A total of 158 PsA patients [mean (s. d.) age 52.3 (13) years, 88 (55.7%) females] were analysed. Multivariate linear regression analyses showed a significant association between sonographic enthesitis and sonographic synovitis (β = 0.18, P  = 0.008) and between sonographic enthesitis and sonographic tenosynovitis (β = 0.06, P  = 0.02). These associations were derived from the enthesitis inflammatory subcategory of the MASEI (P   <  0.05). Associations between enthesitis and synovitis were also demonstrated on the level of the elbow, knee and ankle joints (P   <  0.05). In addition, sonographic enthesitis was significantly associated with older age, male sex, swollen joint count, CRP level and physical occupation. Conclusions Sonographic enthesitis is associated with sonographic synovitis and tenosynovitis. The severity of sonographic enthesitis may represent a marker for inflammatory activity in other musculoskeletal domains. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The association between sonographic enthesitis with sonographic synovitis and tenosynovitis in psoriatic arthritis patients

Author

Balulu, Gavriel, primary, Furer, Victoria, additional, Wollman, Jonathan, additional, Levartovsky, David, additional, Aloush, Valerie, additional, Elalouf, Ofir, additional, Sarbagil-Maman, Hagit, additional, Mendel, Liran, additional, Borok, Sara, additional, Paran, Daphna, additional, Elkayam, Ori, additional, and Polachek, Ari, additional

Published
2023
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10. A deep look into the storm: Israeli multi-center experience of coronavirus disease 2019 (COVID-19) in patients with autoimmune inflammatory rheumatic diseases before and after vaccinations

Author

Kharouf, Fadi, primary, Eviatar, Tali, additional, Braun, Maya, additional, Pokroy-Shapira, Elisheva, additional, Brodavka, Michal, additional, Zloof, Yair, additional, Agmon-Levin, Nancy, additional, Toledano, Kochava, additional, Oren, Shirly, additional, Lidar, Merav, additional, Zisman, Devy, additional, Tavor, Yonit, additional, Amit-Vazina, Mirit, additional, Sabbah, Firas, additional, Breuer, Gabriel S., additional, Dagan, Amir, additional, Beshara-Garzuzi, Rima, additional, Markovits, Doron, additional, Elias, Muna, additional, Feld, Joy, additional, Tayer-Shifman, Oshrat, additional, Gazitt, Tal, additional, Reitblatt, Tatiana, additional, Rubin, Limor, additional, Haddad, Amir, additional, Giryes, Sami, additional, Paran, Daphna, additional, Peleg, Hagit, additional, Molad, Yair, additional, Elkayam, Ori, additional, Mevorach, Dror, additional, Balbir-Gurman, Alexandra, additional, and Braun-Moscovici, Yolanda, additional

Published
2023
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15. Synovial monocytes from psoriatic and rheumatoid arthritis patients are modulated differently by TNF inhibitors and glucocorticoids: an ex-vivo study

Author

Gertel, Smadar, primary, Polachek, Ari, additional, Furer, Victoria, additional, Paran, Daphna, additional, Tzemach, Reut, additional, Levartovsky, David, additional, Litinsky, Irena, additional, Anouk, Marina, additional, Meridor, Katya, additional, Nochomovitz, Hila, additional, Wollman, Jonatan, additional, Berman, Mark, additional, Borok, Sara, additional, and Elkayam, Ori, additional

Published
2022
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16. Immunogenicity induced by two and three doses of the BNT162b2 mRNA vaccine in patients with autoimmune inflammatory rheumatic diseases and immunocompetent controls: a longitudinal multicentre study

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Freund, Tal, additional, Peleg, Hagit, additional, Paran, Daphna, additional, Levartovsky, David, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Elalouf, Ofir, additional, Polachek, Ari, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazitt, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Gertel, Smadar, additional, Pel, Sara, additional, Nevo, Sharon, additional, Hagin, David, additional, Zisman, Devy, additional, and Elkayam, Ori, additional

Published
2022
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17. Predictors of Immunogenic Response to the BNT162b2 mRNA COVID-19 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases Treated with Rituximab

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Braun-Moscovici, Yolanda, additional, Balbir-Gurman, Alexandra, additional, Paran, Daphna, additional, Levartovsky, David, additional, Zisapel, Michael, additional, Elalouf, Ofir, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Polachek, Ari, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazitt, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Pel, Sara, additional, Nevo, Sharon, additional, and Elkayam, Ori, additional

Published
2022
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20. Predictors of an Immunogenic Response to the BNT162b2 mRNA COVID-19 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases Treated with Rituximab: A Multicenter Study

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Braun-Moscovici, Yolanda, additional, Balbir-Gurman, Alexandra, additional, Paran, Daphna, additional, Levartovsky, David, additional, Zisapel, Michael, additional, Elalouf, Ofir, additional, Kaufman, Ilana, additional, Broyde, Adi, additional, Polachek, Ari, additional, Meridor, Katya, additional, Nochomovitz, Hila, additional, Silberman, Adi, additional, Rosenberg, Dana, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazzit, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Pel, Sara, additional, Nevo, Sharon, additional, and Elkayam, Ori, additional

Published
2021
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23. Role of ultrasound for assessment of psoriatic arthritis patients with fibromyalgia

Author

Polachek, Ari, primary, Furer, Victoria, additional, Zureik, Mirna, additional, Nevo, Sharon, additional, Mendel, Liran, additional, Levartovsky, David, additional, Wollman, Jonathan, additional, Aloush, Valerie, additional, Tzemach, Reut, additional, Elalouf, Ofir, additional, Anouk, Marina, additional, Berman, Mark, additional, Kaufman, Ilana, additional, Carmi, Or, additional, Lahat, Yael, additional, Eviatar, Tali, additional, Padova, Hagit, additional, Sarbagil-Maman, Hagit, additional, Borok, Sara, additional, Broyde, Adi, additional, Eder, Lihi, additional, Paran, Daphna, additional, and Elkayam, Ori, additional

Published
2021
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24. Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study

Author

Furer, Victoria, primary, Eviatar, Tali, additional, Zisman, Devy, additional, Peleg, Hagit, additional, Paran, Daphna, additional, Levartovsky, David, additional, Zisapel, Michael, additional, Elalouf, Ofir, additional, Kaufman, Ilana, additional, Meidan, Roni, additional, Broyde, Adi, additional, Polachek, Ari, additional, Wollman, Jonathan, additional, Litinsky, Ira, additional, Meridor, Katya, additional, Nochomovitz, Hila, additional, Silberman, Adi, additional, Rosenberg, Dana, additional, Feld, Joy, additional, Haddad, Amir, additional, Gazzit, Tal, additional, Elias, Muna, additional, Higazi, Nizar, additional, Kharouf, Fadi, additional, Shefer, Gabi, additional, Sharon, Orly, additional, Pel, Sara, additional, Nevo, Sharon, additional, and Elkayam, Ori, additional

Published
2021
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25. Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases

Author

Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Furer, Victoria, Rondaan, Christien, Agmon-Levin, Nancy, Van Assen, Sander, Bijl, Marc, Kapetanovic, Meliha Crnkic, De Thurah, Annette, Mueller-Ladner, Ulf, Paran, Daphna, Schreiber, Karen, Warnatz, Klaus, Wulffraat, Nico M., Elkayam, Ori, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Furer, Victoria, Rondaan, Christien, Agmon-Levin, Nancy, Van Assen, Sander, Bijl, Marc, Kapetanovic, Meliha Crnkic, De Thurah, Annette, Mueller-Ladner, Ulf, Paran, Daphna, Schreiber, Karen, Warnatz, Klaus, Wulffraat, Nico M., and Elkayam, Ori

Published
2021

26. Musculoskeletal manifestations of cat scratch disease

Author

Maman, Eran, Bickels, Jacob, Ephros, Moshe, Paran, Daphna, Comaneshter, Doron, Metzkor-Cotter, Einat, Avidor, Boaz, Varon-Graidy, Merav, Wientroub, Shlomo, and Giladi, Michael

Subjects
Cat-scratch disease -- Diagnosis, Cat-scratch disease -- Physiological aspects, Cat-scratch disease -- Care and treatment, Osteomyelitis -- Causes of, Osteomyelitis -- Care and treatment, Health, Health care industry
Published
2007

30. Ultrasound, magnetic resonance imaging and radiography of the finger joints in psoriatic arthritis patients

Author

Polachek, Ari, primary, Furer, Victoria, additional, Zureik, Mirna, additional, Nevo, Sharon, additional, Mendel, Liran, additional, Levartovsky, David, additional, Wollman, Jonathan, additional, Aloush, Valerie, additional, Tzemah, Reut, additional, Elalouf, Ofir, additional, Anouk, Marina, additional, Berman, Mark, additional, Kaufman, Ilana, additional, Lahat, Yael, additional, Sarbagil-Maman, Hagit, additional, Borok, Sara, additional, Broyde, Adi, additional, Eder, Lihi, additional, Paran, Daphna, additional, Iluz, Moshe, additional, Eshed, Iris, additional, and Elkayam, Ori, additional

Published
2021
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32. Sex-Based Differences in Sonographic and Clinical Findings Among Patients With Psoriatic Arthritis

Author

Furer, Victoria, Wollman, Jonathan, Levartovsky, David, Aloush, Valerie, Elalouf, Ofir, Sarbagil-Maman, Hagit, Mendel, Liran, Borok, Sara, Paran, Daphna, Elkayam, Ori, and Polachek, Ari

Abstract

ObjectiveTo investigate sex-based sonographic differences in patients with psoriatic arthritis (PsA).MethodsThe study population included consecutive prospectively recruited patients with PsA, as determined by the CASPAR (Classification for Psoriatic Arthritis) criteria, who underwent clinical and physical examinations, followed by a detailed ultrasound (US) evaluation (greyscale and Doppler). US evaluation included 52 joints, 40 tendons, and 14 points of entheses (Modified Madrid Sonographic Enthesis Index [MASEI] plus lateral epicondyles) performed by an experienced sonographer blinded to the clinical data. The US score was based on the summation of a semiquantitative score for synovitis, tenosynovitis, and enthesitis. The US enthesitis score was categorized into inflammatory lesions (ie, hypoechogenicity, thickening, bursitis, and Doppler) and structural lesions (ie, enthesophytes/calcifications and erosions).ResultsThe study population of 158 patients included 70 males and 88 females. The males had higher rates of employment (P= 0.01), Psoriasis Area and Severity Index scores (P= 0.04), and mean swollen joint counts (P= 0.04). The total US score and its subcategory scores—the synovitis and tenosynovitis scores—were similar for both sexes, whereas the total enthesitis score and its subcategory score—the inflammatory enthesitis score—were significantly higher for the males compared to the females (P= 0.01 and P= 0.005, respectively). Hypoechogenicity, thickening, and enthesophytes were more prevalent in males compared to females (P< 0.05). Multivariate ordinal logistic regression models showed that male sex was associated with a higher US inflammatory enthesitis score compared to female sex (odds ratio 1.96, P= 0.02).ConclusionSonographic enthesitis was more prevalent in males compared to females with PsA. These differences were not reflected by enthesitis disease activity scores derived from clinical assessment.

Published
2023
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37. Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases

Author

Furer, Victoria, primary, Rondaan, Christien, additional, Agmon-Levin, Nancy, additional, van Assen, Sander, additional, Bijl, Marc, additional, Kapetanovic, Meliha Crnkic, additional, de Thurah, Annette, additional, Mueller-Ladner, Ulf, additional, Paran, Daphna, additional, Schreiber, Karen, additional, Warnatz, Klaus, additional, Wulffraat, Nico M, additional, and Elkayam, Ori, additional

Published
2021
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38. Prevalence of Nonradiographic Sacroiliitis in Patients With Psoriatic Arthritis: A Real-life Observational Study

Author

Furer, Victoria, primary, Levartovsky, David, additional, Wollman, Jonathan, additional, Wigler, Irena, additional, Paran, Daphna, additional, Kaufman, Ilana, additional, Elalouf, Ofir, additional, Borok, Sara, additional, Anouk, Marina, additional, Sarbagil-Maman, Hagit, additional, Berman, Mark, additional, Polachek, Ari, additional, Matz, Hagit, additional, Flusser, Gideon, additional, Druckmann, Ido, additional, Eshed, Iris, additional, and Elkayam, Ori, additional

Published
2021
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39. Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage

Author

Chorin, Ehud, primary, Hochstadt, Aviram, additional, Arad, Uri, additional, Ghantous, Eihab, additional, Gertel, Smadar, additional, Levartovsky, David, additional, Litinsky, Irena, additional, Elaluof, Ofir, additional, Polachek, Ari, additional, Kaufman, Ilana, additional, Aloush, Valerie, additional, Borok, Sara, additional, Wigler, Irena, additional, Wollman, Jonathan, additional, Caspi, Dan, additional, Laufer-Perl, Michal, additional, Letourneau-Shesaf, Sevan, additional, Berliner, Shlomo, additional, Elkayam, Ori, additional, Topilsky, Yan, additional, and Paran, Daphna, additional

Published
2020
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44. sj-pdf-1-lup-10.1177_0961203320947805 - Supplemental material for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage

Author

Chorin, Ehud, Hochstadt, Aviram, Arad, Uri, Eihab Ghantous, Gertel, Smadar, Levartovsky, David, Litinsky, Irena, Elaluof, Ofir, Polachek, Ari, Kaufman, Ilana, Aloush, Valerie, Borok, Sara, Wigler, Irena, Wollman, Jonathan, Caspi, Dan, Laufer-Perl, Michal, Letourneau-Shesaf, Sevan, Berliner, Shlomo, Elkayam, Ori, Topilsky, Yan, and Paran, Daphna

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-lup-10.1177_0961203320947805 for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage by Ehud Chorin, Aviram Hochstadt, Uri Arad, Eihab Ghantous, Smadar Gertel, David Levartovsky, Irena Litinsky, Ofir Elaluof, Ari Polachek, Ilana Kaufman, Valerie Aloush, Sara Borok, Irena Wigler, Jonathan Wollman, Dan Caspi, Michal Laufer-Perl, Sevan Letourneau-Shesaf, Shlomo Berliner, Ori Elkayam, Yan Topilsky and Daphna Paran in Lupus

Published
2020
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45. sj-pdf-2-lup-10.1177_0961203320947805 - Supplemental material for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage

Author

Chorin, Ehud, Hochstadt, Aviram, Arad, Uri, Eihab Ghantous, Gertel, Smadar, Levartovsky, David, Litinsky, Irena, Elaluof, Ofir, Polachek, Ari, Kaufman, Ilana, Aloush, Valerie, Borok, Sara, Wigler, Irena, Wollman, Jonathan, Caspi, Dan, Laufer-Perl, Michal, Letourneau-Shesaf, Sevan, Berliner, Shlomo, Elkayam, Ori, Topilsky, Yan, and Paran, Daphna

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-2-lup-10.1177_0961203320947805 for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage by Ehud Chorin, Aviram Hochstadt, Uri Arad, Eihab Ghantous, Smadar Gertel, David Levartovsky, Irena Litinsky, Ofir Elaluof, Ari Polachek, Ilana Kaufman, Valerie Aloush, Sara Borok, Irena Wigler, Jonathan Wollman, Dan Caspi, Michal Laufer-Perl, Sevan Letourneau-Shesaf, Shlomo Berliner, Ori Elkayam, Yan Topilsky and Daphna Paran in Lupus

Published
2020
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50. Cat-Scratch Disease–Associated Arthropathy

Author

Giladi, Michael, Maman, Eran, Paran, Daphna, Bickels, Jacob, Comaneshter, Doron, Avidor, Boaz, Varon-Graidy, Merav, Ephros, Moshe, and Wientroub, Shlomo

Published
2005

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