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7. Carboxymethyl-sagocellulose-stabilized Fe3O4 nanoparticles with 5-fluorouracil as photothermal agents for tumor ablation.

Author

Veeramachineni, Anand Kumar, Sathasivam, Thenapakiam, Paramasivam, Ragul, Muniyandy, Saravanan, Khamis, Shafii Bin, Lim, Yau Yan, and Pushpamalar, Janarthanan

Subjects
PHOTOTHERMAL effect, IRON oxide nanoparticles, NANOMEDICINE, NANOPARTICLES, FLUOROURACIL, COMPUTED tomography, MAGNETIC nanoparticles
Abstract

Background: There is a continuous growth of interest in the development of nano-drug delivery systems that could combine therapy and diagnosis of cancer. Results: Novel multifunctional superparamagnetic iron oxide nanoparticles (SPIONs, chemically Fe3O4) conjugated with carboxymethyl sagocellulose (CMSC), and 5-fluorouracil (Fe3O4-CMSC-5FU) were synthesized. The conjugated nanoparticles have the magnetic properties of the SPIONs, which allows the nanoparticles to be localized at the target area by applying an external magnetic field. SPIONs generate heat upon exposure to laser lights, resulting in a photothermic effect. The drug-loading efficiency of 5-FU into the SPIONs-CMSC conjugated nanoparticles was 70 to 84% w/w which could release the drug at intracellular pH (5.4) of cancer cells and resist drug release at pH 7.2. In vivo studies using mice models confirmed the nanoparticles could efficiently deliver 5-FU only to the cancer cells and the anticancer effect was enhanced by laser-induced hyperthermia. Conclusions: The combination of targeted delivery of 5-FU with photothermal therapy (PTT) looks promising for selective killing of cancer cells. Furthermore, SPIONs are an excellent contrasting agent for use in computerized tomography (CT) imaging for determining the tumor location and monitoring the progress of the therapy. The focus of this work was the oncological application of multifunctional Fe3O4-CMSC-5FU nanoparticle conjugates, with an emphasis on therapeutic, diagnostic and prognostic purposes. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Is AMR in Dairy Products a Threat to Human Health? An Updated Review on the Origin, Prevention, Treatment, and Economic Impacts of Subclinical Mastitis

Author

Paramasivam,Ragul, Gopal,Dhinakar Raj, Dhandapani,Ranjithkumar, Subbarayalu,Ramalakshmi, Elangovan,Mahesh Prabu, Prabhu,Bhavadharani, Veerappan,Veeramani, Nandheeswaran,Arunkumar, Paramasivam,Siddarth, Muthupandian,Saravanan, Paramasivam,Ragul, Gopal,Dhinakar Raj, Dhandapani,Ranjithkumar, Subbarayalu,Ramalakshmi, Elangovan,Mahesh Prabu, Prabhu,Bhavadharani, Veerappan,Veeramani, Nandheeswaran,Arunkumar, Paramasivam,Siddarth, and Muthupandian,Saravanan

Abstract

Ragul Paramasivam,1 Dhinakar Raj Gopal,2 Ranjithkumar Dhandapani,1 Ramalakshmi Subbarayalu,1 Mahesh Prabu Elangovan,1 Bhavadharani Prabhu,1 Veeramani Veerappan,1 Arunkumar Nandheeswaran,1 Siddarth Paramasivam,1 Saravanan Muthupandian3,4 1Research and Development Division, Chimertech Private Limited, Chennai, India; 2Department of Animal Biotechnology, Madras Veterinary College, Tamilnadu Veterinary and Animal Science University (TANUVAS), Chennai, 600007, India; 3AMR and Nanotherapeutics Lab, Centre for Transdisciplinary Research (CFTR), Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India; 4Division of Biomedical Science, College of Health Sciences, School of Medicine, Mekelle University, Mekelle, EthiopiaCorrespondence: Saravanan Muthupandian, Email bioinfosaran@gmail.comBackground: Bovine mastitis is the most frequent and costly illness impacting dairy herds worldwide. The presence of subclinical mastitis in dairy cows has an impact on the decreased output of milk and milk quality, culling of affected cows, mortality rate, as well as mastitis-related treatment expenses, generating significant financial loss to the dairy industry. The pathogenic bacteria invade through the mammary gland, which then multiply in the milk-producing tissues causing infection, and the presence of pathogenic bacteria in milk is concerning, jeopardizes human health, and also has public health consequences. Intervention to promote herd health is essential to protect public health and the economy.Results: This review attempts to provide an overview of subclinical mastitis, including mastitis in different species, the effect of mastitis on human health and its pathogenic mechanism, the prevalence and incidence of subclinical mastitis, and current preventive, diagnostic, and treatment methods for subclinical mastitis. It also elaborates on the management practices that should be followed by the farms to improve her

Published
2023

11. Is AMR in Dairy Products a Threat to Human Health? An Updated Review on the Origin, Prevention, Treatment, and Economic Impacts of Subclinical Mastitis

Author

Paramasivam, Ragul, primary, Gopal, Dhinakar Raj, additional, Dhandapani, Ranjithkumar, additional, Subbarayalu, Ramalakshmi, additional, Elangovan, Mahesh Prabu, additional, Prabhu, Bhavadharani, additional, Veerappan, Veeramani, additional, Nandheeswaran, Arunkumar, additional, Paramasivam, Siddarth, additional, and Muthupandian, Saravanan, additional

Published
2023
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12. Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Factors among Dental Caries-Suspected Patients Attending the Ayder Comprehensive Specialized Hospital and Private Dental Clinic in Mekelle, Northern Ethiopia

Author

Kiros, Abu, primary, Saravanan, Muthupandian, additional, Niguse, Selam, additional, Gebregziabher, Dawit, additional, Kahsay, Getahun, additional, Dhandapani, Ranjithkumar, additional, Paramasivam, Ragul, additional, Araya, Tadele, additional, and Asmelash, Tsehaye, additional

Published
2022
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13. Efficient One-Pot Synthesis of TiO2/ZrO2/SiO2 Ternary Nanocomposites Using Prunus × Yedoensis Leaf Extract for Enhanced Photocatalytic Dye Degradation

Author

Manikandan, Velu, primary, Packialakshmi, J. Saranya, additional, Bharti, Bandna, additional, Jayanthi, Palaniyappan, additional, Dhandapani, Ranjithkumar, additional, Velmurugan, Palanivel, additional, Elango, Duraisamy, additional, Paramasivam, Ragul, additional, Mohanavel, Vinayagam, additional, Syed, Asad, additional, Elgorban, Abdhallah M., additional, Bahkali, Ali H., additional, and Muthupandian, Saravanan, additional

Published
2022
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16. In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis

Author

Ajucarmelprecilla, Arulprakasam, primary, Pandi, Jhansi, additional, Dhandapani, Ranjithkumar, additional, Ramanathan, Saikishore, additional, Chinnappan, Jayaprakash, additional, Paramasivam, Ragul, additional, Thangavelu, Sathiamoorthi, additional, Mohammed Ghilan, Abdul-Kareem, additional, Aljohani, Saad Ali S., additional, Oyouni, Atif Abdulwahab A., additional, Farasani, Abdullah, additional, Altayar, Malik A., additional, Althagafi, Hussam Awwadh E., additional, Alzahrani, Othman R., additional, Durairaj, Kaliannan, additional, and Shrestha, Anupama, additional

Published
2022
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24. Carboxymethyl-sagocellulose-stabilized Fe3O4nanoparticles with 5-fluorouracil as photothermal agents for tumor ablation

Author

Veeramachineni, Anand Kumar, Sathasivam, Thenapakiam, Paramasivam, Ragul, Muniyandy, Saravanan, Khamis, Shafii Bin, Lim, Yau Yan, and Pushpamalar, Janarthanan

Abstract

Background: There is a continuous growth of interest in the development of nano-drug delivery systems that could combine therapy and diagnosis of cancer. Results: Novel multifunctional superparamagnetic iron oxide nanoparticles (SPIONs, chemically Fe3O4) conjugated with carboxymethyl sagocellulose (CMSC), and 5-fluorouracil (Fe3O4-CMSC-5FU) were synthesized. The conjugated nanoparticles have the magnetic properties of the SPIONs, which allows the nanoparticles to be localized at the target area by applying an external magnetic field. SPIONs generate heat upon exposure to laser lights, resulting in a photothermic effect. The drug-loading efficiency of 5-FU into the SPIONs-CMSC conjugated nanoparticles was 70 to 84% w/w which could release the drug at intracellular pH (5.4) of cancer cells and resist drug release at pH 7.2. In vivo studies using mice models confirmed the nanoparticles could efficiently deliver 5-FU only to the cancer cells and the anticancer effect was enhanced by laser-induced hyperthermia. Conclusions: The combination of targeted delivery of 5-FU with photothermal therapy (PTT) looks promising for selective killing of cancer cells. Furthermore, SPIONs are an excellent contrasting agent for use in computerized tomography (CT) imaging for determining the tumor location and monitoring the progress of the therapy. The focus of this work was the oncological application of multifunctional Fe3O4-CMSC-5FU nanoparticle conjugates, with an emphasis on therapeutic, diagnostic and prognostic purposes.

Published
2024
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27. Efficient One-Pot Synthesis of TiO 2 /ZrO 2 /SiO 2 Ternary Nanocomposites Using Prunus × Yedoensis Leaf Extract for Enhanced Photocatalytic Dye Degradation.

Author

Manikandan V, Packialakshmi JS, Bharti B, Jayanthi P, Dhandapani R, Velmurugan P, Elango D, Paramasivam R, Mohanavel V, Syed A, Elgorban AM, Bahkali AH, and Muthupandian S

Subjects
Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Escherichia coli, Plant Extracts chemistry, Plant Extracts pharmacology, Silicon Dioxide chemistry, Titanium, Nanocomposites chemistry, Prunus
Abstract

A simple, efficient, and ecofriendly method was employed to synthesize TiO 2 /ZrO 2 /SiO 2 ternary nanocomposites using Prunus × yedoensis leaf extract (PYLE) that shows improved photocatalytic and antibacterial properties. The characterization of the obtained nanocomposites was done by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, field-emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopic (EDS) analysis. The synthesized ternary nanocomposites with nanoscale pore diameters were investigated for the elimination of Reactive Red 120 (RR120) dye. The obtained results showed about 96.2% removal of RR120 dye from aqueous solution under sunlight irradiation. Furthermore, it shows promising antibacterial activity against Staphylococcus aureus and Escherichia coli . The improved photocatalytic and antibacterial activity of TiO 2 /ZrO 2 /SiO 2 may bring unique insights into the production of ternary nanocomposites and their applications in the environment and biomedical field., Competing Interests: The authors declare that they have no conflict of interest., (Copyright © 2022 Velu Manikandan et al.)

Published
2022
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