1. Multiple parietal pathways are associated with rTMS-induced hippocampal network enhancement and episodic memory changes.
- Author
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Freedberg M, Cunningham CA, Fioriti CM, Murillo J, Reeves JA, Taylor PA, Sarlls JE, and Wassermann EM
- Subjects
- Adult, Diffusion Tensor Imaging, Female, Humans, Individuality, Male, Neural Pathways anatomy & histology, Neural Pathways diagnostic imaging, Neural Pathways physiology, Young Adult, Connectome, Hippocampus anatomy & histology, Hippocampus diagnostic imaging, Hippocampus physiology, Magnetic Resonance Imaging, Memory, Episodic, Nerve Net anatomy & histology, Nerve Net diagnostic imaging, Nerve Net physiology, Parahippocampal Gyrus anatomy & histology, Parahippocampal Gyrus diagnostic imaging, Parahippocampal Gyrus physiology, Parietal Lobe anatomy & histology, Parietal Lobe diagnostic imaging, Parietal Lobe physiology, Transcranial Magnetic Stimulation
- Abstract
Repetitive transcranial magnetic stimulation (rTMS) of the inferior parietal cortex (IPC) increases resting-state functional connectivity (rsFC) of the hippocampus with the precuneus and other posterior cortical areas and causes proportional improvement of episodic memory. The anatomical pathway(s) responsible for the propagation of these effects from the IPC is unknown and may not be direct. In order to assess the relative contributions of candidate pathways from the IPC to the MTL via the parahippocampal cortex and precuneus, to the effects of rTMS on rsFC and memory improvement, we used diffusion tensor imaging to measure the extent to which individual differences in fractional anisotropy (FA) in these pathways accounted for individual differences in response. FA in the IPC-parahippocampal pathway and several MTL pathways predicted changes in rsFC. FA in both parahippocampal and hippocampal pathways was related to changes in episodic, but not procedural, memory. These results implicate pathways to the MTL in the enhancing effect of parietal rTMS on hippocampal rsFC and memory., (Published by Elsevier Inc.)
- Published
- 2021
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