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1. Abstract 2934: BYON4228, an antagonistic SIRPα mAb with a unique and favorable preclinical profile compared to three comparator SIRPα mAbs

Author

van Helden, Mary, primary, Zwarthoff, Seline, additional, Arends, Roel, additional, Reinieren-Beeren, Inge, additional, Parade, Marc, additional, Driessen-Engels, Lilian, additional, de Laat-Arts, Karin, additional, Damming, Desiree, additional, Santegoeds-Lenssen, Ellen, additional, van Kuppeveld, Daphne, additional, Lodewijks, Imke, additional, Mattaar, Ellen, additional, Olsman, Hugo, additional, Matlung, Hanke, additional, Franke, Katka, additional, Stokman, Marloes, additional, de Wit, Benny, additional, Glaudemans, Dirk, additional, van Wijk, Danielle, additional, Stoffels, Lonnie Joosten, additional, Schouten, Jan, additional, Boersema, Paul, additional, van der Vleuten, Monique, additional, Sanderink, Jorien, additional, Kappers, Wendy, additional, Dobbelsteen, Diels van den, additional, Timmers, Marco, additional, Ubink, Ruud, additional, Rouwendal, Gerard, additional, Verheijden, Gijs, additional, van der Lee, Miranda M.C., additional, Dokter, Wim, additional, and Berg, Timo van den, additional

Published
2023
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2. Data from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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3. Supplementary Tables from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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4. Supplementary Figures from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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6. Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies

Author

LS Immunologie, Immunologie, dI&I RA-I&I I&I, Segués, Aina, van Duijnhoven, Sander M J, Parade, Marc, Driessen, Lilian, Vukovic, Nataša, Zaiss, Dietmar, Sijts, Alice J A M, Berraondo, Pedro, van Elsas, Andrea, LS Immunologie, Immunologie, dI&I RA-I&I I&I, Segués, Aina, van Duijnhoven, Sander M J, Parade, Marc, Driessen, Lilian, Vukovic, Nataša, Zaiss, Dietmar, Sijts, Alice J A M, Berraondo, Pedro, and van Elsas, Andrea

Published
2021

7. A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode

Author

Pande, Vineet, primary, Sun, Weimei, additional, Beke, Lijs, additional, Berthelot, Didier, additional, Brehmer, Dirk, additional, Brown, David, additional, Corbera, Jordi, additional, Irving, Steve, additional, Meerpoel, Lieven, additional, Nys, Thomas, additional, Parade, Marc, additional, Robinson, Colin, additional, Sommen, Cois, additional, Viellevoye, Marcel, additional, Wu, Tongfei, additional, and Thuring, Jan Willem, additional

Published
2020
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8. Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Author

Beke, Lijs, primary, Kig, Cenk, additional, Linders, Joannes T. M., additional, Boens, Shannah, additional, Boeckx, An, additional, van Heerde, Erika, additional, Parade, Marc, additional, De Bondt, An, additional, Van den Wyngaert, Ilse, additional, Bashir, Tarig, additional, Ogata, Souichi, additional, Meerpoel, Lieven, additional, Van Eynde, Aleyde, additional, Johnson, Christopher N., additional, Beullens, Monique, additional, Brehmer, Dirk, additional, and Bollen, Mathieu, additional

Published
2018
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9. Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models

Author

Brehmer, Dirk, primary, Wu, Tongfei, additional, Mannens, Geert, additional, Beke, Lijs, additional, Vinken, Petra, additional, Gaffney, Dana, additional, Sun, Weimei, additional, Pande, Vineet, additional, Thuring, Jan-Willem, additional, Millar, Hillary, additional, Poggesi, Italo, additional, Somers, Ivan, additional, Boeckx, An, additional, Parade, Marc, additional, Heerde, Erika van, additional, Nys, Thomas, additional, Yanovich, Carol, additional, Herkert, Barbara, additional, Verhulst, Tinne, additional, Jardin, Marc Du, additional, Meerpoel, Lieven, additional, Moy, Christopher, additional, Diels, Gaston, additional, Viellevoye, Marcel, additional, Schepens, Wim, additional, Poncelet, Alain, additional, Linders, Joannes T., additional, Lawson, Edward C., additional, Edwards, James P., additional, Chetty, Dushen, additional, Laquerre, Sylvie, additional, and Lorenzi, Matthew V., additional

Published
2017
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10. Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling

Author

Wandinger, Sebastian K., primary, Lahortiga, Idoya, additional, Jacobs, Kris, additional, Klammer, Martin, additional, Jordan, Nicole, additional, Elschenbroich, Sarah, additional, Parade, Marc, additional, Jacoby, Edgar, additional, Linders, Joannes T. M., additional, Brehmer, Dirk, additional, Cools, Jan, additional, and Daub, Henrik, additional

Published
2016
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11. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Author

Beke, Lijs, primary, Kig, Cenk, additional, Linders, Joannes T. M., additional, Boens, Shannah, additional, Boeckx, An, additional, van Heerde, Erika, additional, Parade, Marc, additional, De Bondt, An, additional, Van den Wyngaert, Ilse, additional, Bashir, Tarig, additional, Ogata, Souichi, additional, Meerpoel, Lieven, additional, Van Eynde, Aleyde, additional, Johnson, Christopher N., additional, Beullens, Monique, additional, Brehmer, Dirk, additional, and Bollen, Mathieu, additional

Published
2015
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12. CD74-NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Dassler, Juliane, Malchers, Florian, Schottle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T., Wright, Gavin M., Russell, Prudence A., Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Helene, Moro-Sibilot, Denis, Brambilla, Christian G., Lantuejoul, Sylvie, Altmuller, Janine, Becker, Christian, Nurnberg, Peter, Heuckmann, Johannes M., Stoelben, Erich, Petersen, Iver, Clement, Joachim H., Saenger, Joerg, Muscarella, Lucia A., la Torre, Annamaria, Fazio, Vito M., Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C., Buettner, Reinhard, Zander, Thomas, Wolf, Jurgen, Perner, Sven, Ansen, Sascha, Haas, Stefan A., Yatabe, Yasushi, Thomas, Roman K., Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Dassler, Juliane, Malchers, Florian, Schottle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T., Wright, Gavin M., Russell, Prudence A., Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Helene, Moro-Sibilot, Denis, Brambilla, Christian G., Lantuejoul, Sylvie, Altmuller, Janine, Becker, Christian, Nurnberg, Peter, Heuckmann, Johannes M., Stoelben, Erich, Petersen, Iver, Clement, Joachim H., Saenger, Joerg, Muscarella, Lucia A., la Torre, Annamaria, Fazio, Vito M., Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C., Buettner, Reinhard, Zander, Thomas, Wolf, Jurgen, Perner, Sven, Ansen, Sascha, Haas, Stefan A., Yatabe, Yasushi, and Thomas, Roman K.

Abstract

We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional fusion-positive tumors, all of which were of the invasive mucinous subtype. Mechanistically, CD74-NRG1 leads to extracellular expression of the EGF-like domain of NRG1 III- ss 3, thereby providing the ligand for ERBB2-ERBB3 receptor complexes. Accordingly, ERBB2 and ERBB3 expression was high in the index case, and expression of phospho-ERBB3 was specifically found in tumors bearing the fusion ( P < 0.0001). Ectopic expression of CD74-NRG1 in lung cancer cell lines expressing ERBB2 and ERBB3 activated ERBB3 and the PI3K-AKT pathway, and led to increased colony formation in soft agar. Thus, CD74-NRG1 gene fusions are activating genomic alterations in invasive mucinous adenocarcinomas and may offer a therapeutic opportunity for a lung tumor subtype with, so far, no effective treatment. SIGNIFICANCE: CD74-NRG1 fusions may represent a therapeutic opportunity for invasive mucinous lung adenocarcinomas, a tumor with no effective treatment that frequently presents with multifocal unresectable disease. Cancer Discov; 4(4); 415- 22. (c) 2014 AACR.

Published
2014

13. Abstract 2936: JNJ-47117096, a selective small molecule inhibitor of the MELK oncogene decreases DNA damage tolerance in highly proliferating cancer cells

Author

Beke, Lijs, primary, Linders, Joannes T.m., additional, Kig, Cenk, additional, Boeckx, An, additional, Heerde, Erika van, additional, Wuyts, Dirk, additional, Parade, Marc, additional, Meerpoel, Lieven, additional, Johnson, Chris, additional, Beullens, Monique, additional, Bollen, Mathieu, additional, and Brehmer, Dirk, additional

Published
2014
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14. CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, additional, Osada, Hirotaka, additional, Sun, Ruping, additional, Menon, Roopika, additional, Leenders, Frauke, additional, Ortiz-Cuaran, Sandra, additional, Peifer, Martin, additional, Bos, Marc, additional, Daßler, Juliane, additional, Malchers, Florian, additional, Schöttle, Jakob, additional, Vogel, Wenzel, additional, Dahmen, Ilona, additional, Koker, Mirjam, additional, Ullrich, Roland T., additional, Wright, Gavin M., additional, Russell, Prudence A., additional, Wainer, Zoe, additional, Solomon, Benjamin, additional, Brambilla, Elisabeth, additional, Nagy-Mignotte, Hélène, additional, Moro-Sibilot, Denis, additional, Brambilla, Christian G., additional, Lantuejoul, Sylvie, additional, Altmüller, Janine, additional, Becker, Christian, additional, Nürnberg, Peter, additional, Heuckmann, Johannes M., additional, Stoelben, Erich, additional, Petersen, Iver, additional, Clement, Joachim H., additional, Sänger, Jörg, additional, Muscarella, Lucia A., additional, la Torre, Annamaria, additional, Fazio, Vito M., additional, Lahortiga, Idoya, additional, Perera, Timothy, additional, Ogata, Souichi, additional, Parade, Marc, additional, Brehmer, Dirk, additional, Vingron, Martin, additional, Heukamp, Lukas C., additional, Buettner, Reinhard, additional, Zander, Thomas, additional, Wolf, Jürgen, additional, Perner, Sven, additional, Ansén, Sascha, additional, Haas, Stefan A., additional, Yatabe, Yasushi, additional, and Thomas, Roman K., additional

Published
2014
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15. Reversible infertility in a liver receptor homologue-1 (LRH-1)-knockdown mouse model.

Author

Gerrits, Han, Parade', Marc C. B. C., Koonen-Reemst, Annemie M. C. B., Bakker, Nicole E. C., Timmer-Hellings, Lenita, Gelpke, Maarten D. Sollewijn, and Gossen, Jan A.

Subjects
*STEROID hormone synthesis, *MICROARRAY technology, *PROGESTERONE, *FOLLICLE-stimulating hormone, *CONTRACEPTIVES, *CHOLESTEROL, *GONADOTROPIN, *THERAPEUTICS
Abstract

Liver receptor homologue-1 (LRH-1) is an orphan nuclear receptor that has been implicated in steroid hormone biosynthesis and fertility. Herein we describe a transgenic inducible short hairpin (sh) RNA mouse model that was used to study the effect of transient LRH-1 knockdown in vivo. Induction of expression of the shRNA directed against LRH-1 for 2-6 weeks resulted in 80% knockdown of LRH-1 protein in the ovary and complete infertility. Gonadotropin hyperstimulation could not rescue the observed defects in ovulation and corpus luteum formation in LRH-1-knockdown mice. The infertility phenotype was fully reversible because LRH-1-knockdown females became pregnant and delivered normal size litters and healthy pups after cessation of LRH-1 shRNA expression. Timed ovarian microarray analysis showed that, in line with the observed decrease in plasma progesterone levels, key steroid biosynthesis genes, namely Star, Cyp11a1, Hsd3b and Scarb1, were downregulated in LRH-1-knockdown ovaries. In contrast with what has been described previously, no clear effect was observed on oestrogenic activity in LRH-1-knockdown mice. Only Sult1e1 and, surprisingly, Hsd17b7 expression was modulated with potentially opposite effects on oestradiol bioavailability. In conclusion, the fully reversible infertility phenotype of LRH-1-knockdown mice shows the feasibility of an LRH-1 antagonist as new contraceptive therapy with a mechanism of action that most prominently affects cholesterol availability and progesterone production. [ABSTRACT FROM AUTHOR]

Published
2014
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