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Your search keyword '"Parache, Robert-Michel"' showing total 9 results
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9 results on '"Parache, Robert-Michel"'

5. Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-control study

Author

Mignotte, Hervé, primary, Lasset, Christine, additional, Bonadona, Valérie, additional, Lesur, Anne, additional, Luporsi, Elisabeth, additional, Rodier, Jean-François, additional, Cutuli, Bruno, additional, Lasry, Serge, additional, Mauriac, Louis, additional, Granon, Claire, additional, Kerr, Christine, additional, Giard, Sylvie, additional, Hill, Catherine, additional, De Lafontan, Brigitte, additional, De Gislain, Catherine, additional, D'Anjou, Joëlle, additional, Fondrinier, Eric, additional, Lefeuvre, Claudia, additional, Parache, Robert-Michel, additional, and Chauvin, Franck, additional

Published
1998
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9. Induction of syngeneic intradermal and orthotopic epidermal carcinomas in hairless Skh-1 mice as a reproducible model for experiments.

Author

Christophe M, Bisson JF, Notter D, Parache RM, Vigneron C, and Guillemin F

Subjects
Animals, Carcinoma, Squamous Cell chemically induced, Female, Injections, Intradermal, Mice, Mice, Hairless, Reproducibility of Results, Skin Neoplasms chemically induced, Carcinoma, Squamous Cell pathology, Disease Models, Animal, Neoplasm Transplantation methods, Skin Neoplasms pathology
Abstract

Epidermoid carcinomas, clinically and histologically similar to human squamous cell carcinomas (SCC), were obtained in hairless Skh-1 mice. Tumor cells originated from chemically-induced skin cancers. We developed three models of orthotopic skin tumors: (1) intradermal injection of a tumor cell suspension, (2) superficial abrasion of the skin, cell grafting and application of a hydrocolloid dressing, (3) skin incision, seeding and application of a hydrocolloid dressing. Intradermal injection was 100% successful. Skin incision, displaying histological evidence of rapid invasive tumor growth, was 75% successful. Though skin tumor growth after abrasion was only 20% successful, the tumor histogenesis exactly imitated human SCC development. These carcinomas provide research models for further experiments such as photodynamic therapy or antiangiogenesis therapy.

Published
2002

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