216 results on '"Pappata, S."'
Search Results
2. Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps
- Author
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Caminiti, S, Sala, A, Presotto, L, Chincarini, A, Sestini, S, Perani, D, Schillaci, O, Berti, V, Calcagni, M, Cistaro, A, Morbelli, S, Nobili, F, Pappata, S, Volterrani, D, Gobbo, C, Caminiti S. P., Sala A., Presotto L., Chincarini A., Sestini S., Perani D., Schillaci O., Berti V., Calcagni M. L., Cistaro A., Morbelli S., Nobili F., Pappata S., Volterrani D., Gobbo C. L., Caminiti, S, Sala, A, Presotto, L, Chincarini, A, Sestini, S, Perani, D, Schillaci, O, Berti, V, Calcagni, M, Cistaro, A, Morbelli, S, Nobili, F, Pappata, S, Volterrani, D, Gobbo, C, Caminiti S. P., Sala A., Presotto L., Chincarini A., Sestini S., Perani D., Schillaci O., Berti V., Calcagni M. L., Cistaro A., Morbelli S., Nobili F., Pappata S., Volterrani D., and Gobbo C. L.
- Abstract
Purpose: An appropriate healthy control dataset is mandatory to achieve good performance in voxel-wise analyses. We aimed at evaluating [18F]FDG PET brain datasets of healthy controls (HC), based on publicly available data, for the extraction of voxel-based brain metabolism maps at the single-subject level. Methods: Selection of HC images was based on visual rating, after Cook’s distance and jack-knife analyses, to exclude artefacts and/or outliers. The performance of these HC datasets (ADNI-HC and AIMN-HC) to extract hypometabolism patterns in single patients was tested in comparison with the standard reference HC dataset (HSR-HC) by means of Dice score analysis. We evaluated the performance and comparability of the different HC datasets in the assessment of single-subject SPM-based hypometabolism in three independent cohorts of patients, namely, ADD, bvFTD and DLB. Results: Two-step Cook’s distance analysis and the subsequent jack-knife analysis resulted in the selection of n = 125 subjects from the AIMN-HC dataset and n = 75 subjects from the ADNI-HC dataset. The average concordance between SPM hypometabolism t-maps in the three patient cohorts, as obtained with the new datasets and compared to the HSR-HC standard reference dataset, was 0.87 for the AIMN-HC dataset and 0.83 for the ADNI-HC dataset. Pattern expression analysis revealed high overall accuracy (> 80%) of the SPM t-map classification according to different statistical thresholds and sample sizes. Conclusions: The applied procedures ensure validity of these HC datasets for the single-subject estimation of brain metabolism using voxel-wise comparisons. These well-selected HC datasets are ready-to-use in research and clinical settings.
- Published
- 2021
3. Functional neuroimaging brain analysis of different metabolic patterns in treatment-resistant compared to treatment-responsive schizophrenia patients and controls
- Author
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Ciccarelli, M., Iasevoli, F., D'Ambrosio, L., Barone, A., Vellucci, L., Gaudieri, V., Cuocolo, A., Pappatà, S., and de Bartolomeis, A.
- Published
- 2022
- Full Text
- View/download PDF
4. In Vivo Imaging of Anticholinesterase Drugs Used in Alzheimer’s Disease
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Tavitian, B., Pappatà, S., Branly, F., Jobert, A., Dalger, A., Dumont, E., Simonnet, F., Grassi, J., Crouzel, C., DiGiamberardino, L., Giacobini, Ezio, editor, Becker, Robert, editor, Becker, Robert E., editor, Barton, Joyce M., editor, and Brown, Mona, editor
- Published
- 1997
- Full Text
- View/download PDF
5. A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
- Author
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Perani, D, Iaccarino, L, Lammertsma, A, Windhorst, A, Edison, P, Boellaard, R, Hansson, O, Nordberg, A, Jacobs, A, Bottlaender, M, Brooks, D, Carroll, M, Chalon, S, Gee, A, Gerhard, A, Halldin, C, Herholz, K, Herth, M, Hinz, R, Knudsen, G, Kuhnast, B, Lopez-Picon, F, Moresco, R, Pappata, S, Rinne, J, Rodriguez-Vieitez, E, Santiago-Ribeiro, M, Turkheimer, F, Van Laere, K, Varrone, A, Vercouillie, J, Winkeler, A, Perani D., Iaccarino L., Lammertsma A. A., Windhorst A. D., Edison P., Boellaard R., Hansson O., Nordberg A., Jacobs A. H., Bottlaender M., Brooks D., Carroll M. A., Chalon S., Gee A., Gerhard A., Halldin C., Herholz K., Herth M. M., Hinz R., Knudsen G. M., Kuhnast B., Lopez-Picon F., Moresco R. M., Pappata S., Rinne J. O., Rodriguez-Vieitez E., Santiago-Ribeiro M. J., Turkheimer F. E., Van Laere K., Varrone A., Vercouillie J., Winkeler A., Perani, D, Iaccarino, L, Lammertsma, A, Windhorst, A, Edison, P, Boellaard, R, Hansson, O, Nordberg, A, Jacobs, A, Bottlaender, M, Brooks, D, Carroll, M, Chalon, S, Gee, A, Gerhard, A, Halldin, C, Herholz, K, Herth, M, Hinz, R, Knudsen, G, Kuhnast, B, Lopez-Picon, F, Moresco, R, Pappata, S, Rinne, J, Rodriguez-Vieitez, E, Santiago-Ribeiro, M, Turkheimer, F, Van Laere, K, Varrone, A, Vercouillie, J, Winkeler, A, Perani D., Iaccarino L., Lammertsma A. A., Windhorst A. D., Edison P., Boellaard R., Hansson O., Nordberg A., Jacobs A. H., Bottlaender M., Brooks D., Carroll M. A., Chalon S., Gee A., Gerhard A., Halldin C., Herholz K., Herth M. M., Hinz R., Knudsen G. M., Kuhnast B., Lopez-Picon F., Moresco R. M., Pappata S., Rinne J. O., Rodriguez-Vieitez E., Santiago-Ribeiro M. J., Turkheimer F. E., Van Laere K., Varrone A., Vercouillie J., and Winkeler A.
- Abstract
Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
- Published
- 2019
6. Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
- Author
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Perani, D, Iaccarino, L, Jacobs, A, Lammertsma, A, Nordberg, A, Windhorst, A, Gerhard, A, Winkeler, A, Gee, A, Kuhnast, B, Halldin, C, Brooks, D, Rodriguez-Vieitez, E, Turkheimer, F, Lopez-Picon, F, Knudsen, G, Vercouillie, J, Rinne, J, Herholz, K, Van Laere, K, Santiago-Ribeiro, M, Herth, M, Carroll, M, Bottlaender, M, Hansson, O, Edison, P, Hinz, R, Boellaard, R, Moresco, R, Pappata, S, Perani D., Iaccarino L., Jacobs A. H., Lammertsma A. A., Nordberg A., Windhorst A. D., Gerhard A., Winkeler A., Gee A., Kuhnast B., Halldin C., Brooks D., Rodriguez-Vieitez E., Turkheimer F. E., Lopez-Picon F., Knudsen G. M., Vercouillie J., Rinne J. O., Herholz K., Van Laere K., Santiago-Ribeiro M. J., Herth M. M., Carroll M. A., Bottlaender M., Hansson O., Edison P., Hinz R., Boellaard R., Moresco R. M., Pappata S., Perani, D, Iaccarino, L, Jacobs, A, Lammertsma, A, Nordberg, A, Windhorst, A, Gerhard, A, Winkeler, A, Gee, A, Kuhnast, B, Halldin, C, Brooks, D, Rodriguez-Vieitez, E, Turkheimer, F, Lopez-Picon, F, Knudsen, G, Vercouillie, J, Rinne, J, Herholz, K, Van Laere, K, Santiago-Ribeiro, M, Herth, M, Carroll, M, Bottlaender, M, Hansson, O, Edison, P, Hinz, R, Boellaard, R, Moresco, R, Pappata, S, Perani D., Iaccarino L., Jacobs A. H., Lammertsma A. A., Nordberg A., Windhorst A. D., Gerhard A., Winkeler A., Gee A., Kuhnast B., Halldin C., Brooks D., Rodriguez-Vieitez E., Turkheimer F. E., Lopez-Picon F., Knudsen G. M., Vercouillie J., Rinne J. O., Herholz K., Van Laere K., Santiago-Ribeiro M. J., Herth M. M., Carroll M. A., Bottlaender M., Hansson O., Edison P., Hinz R., Boellaard R., Moresco R. M., and Pappata S.
- Abstract
Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
- Published
- 2019
7. Evaluation of age and sex-related metabolic changes in healthy subjects: An italian brain 18f-fdg pet study
- Author
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Allocca, Marialuisa, Linguanti, F., Calcagni, Maria Lucia, Cistaro, A., Gaudieri, V., Guerra, U. P., Morbelli, S., Nobili, F., Pappata, S., Sestini, S., Volterrani, D., Berti, V., Allocca M., Calcagni M. L. (ORCID:0000-0002-0805-8245), Allocca, Marialuisa, Linguanti, F., Calcagni, Maria Lucia, Cistaro, A., Gaudieri, V., Guerra, U. P., Morbelli, S., Nobili, F., Pappata, S., Sestini, S., Volterrani, D., Berti, V., Allocca M., and Calcagni M. L. (ORCID:0000-0002-0805-8245)
- Abstract
Background: 18F-fluorodeoxyglucose (18F-FDG) positron-emission-tomography (PET) allows detection of cerebral metabolic alterations in neurological diseases vs. normal aging. We assess age-and sex-related brain metabolic changes in healthy subjects, exploring impact of activity normalization methods. Methods: brain scans of Italian Association of Nuclear Medicine normative database (151 subjects, 67 Males, 84 Females, aged 20–84) were selected. Global mean, white matter, and pons activity were explored as normalization reference. We performed voxel-based and ROI analyses using SPM12 and IBM-SPSS software. Results: SPM proved a negative correlation between age and brain glucose metabolism involving frontal lobes, anterior-cingulate and insular cortices bilaterally. Narrower clusters were detected in lateral parietal lobes, precuneus, temporal pole and medial areas bilaterally. Normalizing on pons activity, we found a more significant negative correlation and no positive one. ROIs analysis confirmed SPM results. Moreover, a significant age × sex interaction effect was revealed, with worse metabolic reduction in posterior-cingulate cortices in females than males, especially in post-menopausal age. Conclusions: this study demonstrated an age-related metabolic reduction in frontal lobes and in some parieto-temporal areas more evident in females. Results suggested pons as the most appropriate normalization reference. Knowledge of age-and sex-related cerebral metabolic changes is critical to correctly interpreting brain 18F-FDG PET imaging.
- Published
- 2021
8. Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps
- Author
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Caminiti, S. P., Sala, A., Presotto, L., Chincarini, A., Sestini, S., Perani, D., Schillaci, O., Berti, V., Calcagni, M. L., Cistaro, A., Morbelli, S., Nobili, F., Pappata, S., Volterrani, D., Gobbo, C. L., Calcagni M. L. (ORCID:0000-0002-0805-8245), Caminiti, S. P., Sala, A., Presotto, L., Chincarini, A., Sestini, S., Perani, D., Schillaci, O., Berti, V., Calcagni, M. L., Cistaro, A., Morbelli, S., Nobili, F., Pappata, S., Volterrani, D., Gobbo, C. L., and Calcagni M. L. (ORCID:0000-0002-0805-8245)
- Abstract
Purpose: An appropriate healthy control dataset is mandatory to achieve good performance in voxel-wise analyses. We aimed at evaluating [18F]FDG PET brain datasets of healthy controls (HC), based on publicly available data, for the extraction of voxel-based brain metabolism maps at the single-subject level. Methods: Selection of HC images was based on visual rating, after Cook’s distance and jack-knife analyses, to exclude artefacts and/or outliers. The performance of these HC datasets (ADNI-HC and AIMN-HC) to extract hypometabolism patterns in single patients was tested in comparison with the standard reference HC dataset (HSR-HC) by means of Dice score analysis. We evaluated the performance and comparability of the different HC datasets in the assessment of single-subject SPM-based hypometabolism in three independent cohorts of patients, namely, ADD, bvFTD and DLB. Results: Two-step Cook’s distance analysis and the subsequent jack-knife analysis resulted in the selection of n = 125 subjects from the AIMN-HC dataset and n = 75 subjects from the ADNI-HC dataset. The average concordance between SPM hypometabolism t-maps in the three patient cohorts, as obtained with the new datasets and compared to the HSR-HC standard reference dataset, was 0.87 for the AIMN-HC dataset and 0.83 for the ADNI-HC dataset. Pattern expression analysis revealed high overall accuracy (> 80%) of the SPM t-map classification according to different statistical thresholds and sample sizes. Conclusions: The applied procedures ensure validity of these HC datasets for the single-subject estimation of brain metabolism using voxel-wise comparisons. These well-selected HC datasets are ready-to-use in research and clinical settings.
- Published
- 2021
9. Abstracts from the ASENT 2006 Annual Meeting March 8–11, 2006
- Author
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Pritchett, Y., McCarberg, B., Watkin, J., Chappell, A., Robinson, M., Xu, J., Rotz, B., Wernicke, J., Detke, M., Iyengar, S., Henck, J., Bymaster, F., Callaghan, J., Knadler, M., Thase, M., Meratee, M., Chung, J., Schweitzer, J., Byrnes, K., Stoica, B., Di Giovanni, S., De Biase, A., Knoblach, S., Hoffman, E., Faden, A., Michaeli, S., Sorce, D., Öz, G., Ugurbil, K., Garwood, M., Tuite, P., Jett, D., Deberdt, W., Csernansky, J., Buckley, P., Peiskens, J., Lipkovich, I., Kollack-Walter, S., Houston, J., Zhang, Y., Liu-Siefert, H., Buckley, P. F., Csernansky, J. G., Peuskens, J., Kollack-Walker, S., Houston, J. P., Rotelli, M., Theodore, W., Giovacchini, G., Bagic, A., Herscovitch, P., Carson, R., Herholz, K., Weisenbach, S., Hilker, R., Heiss, W., Nahab, F., Hallett, M., El-Khodor, B., Edgar, N., Chen, A., Heyes, M. P., Jiang, Q., Ahmed, S., Pedersen, R., Musgnung, J., Entsuah, R., Nordberg, A., Masdeu, J., Gerhard, A., Ebmeier, K., Pappata, S., Perani, D., van Laere, K., Halldin, C., Salmon, E., Knudsen, G., Robins, S., Fehlings, M., Baptiste, D., Skolnick, B. E., Davis, S. M., Bran, N. C., Mathew, S. E., Mayer, S. A., Kaminski, R. M., Marini, H., Ortinski, P. I., Yonekawa, W., Vicini, S., Rogawski, M. A., Gasior, M., Tang, R., and White, N.
- Published
- 2006
- Full Text
- View/download PDF
10. Longitudinal thalamic diffusion changes after middle cerebral artery infarcts
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Herve, D., Molko, N., Pappata, S., Buffon, F., LeBihan, D., Bousser, M-G, and Chabriat, H.
- Subjects
Cerebral ischemia -- Research ,Cerebral ischemia -- Patient outcomes ,Brain -- Infarction ,Brain -- Research ,Brain -- Patient outcomes ,Tissues ,Magnetic resonance imaging ,Health ,Psychology and mental health - Published
- 2005
11. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. J., Kohncke, G., Castellli, E., Linssen, W., Stegeman, D., Binkhorst, R., Notermans, S., Jaspert, A., Fahsold, R., de Munain, A. Lopez, Cobo, A., Martorell, L., Poza, J. J., Navarrete Palau, D., Emparanza, J. I., Sanchez-Roy, R., Vilchez, J. J., Hernandez, M., Tena, J. Garcia, Perla, C., Koutroumanidis, M., Papathanasopoulos, P., Papadimitriou, A., Papapetropoulos, T. H., Divari, R., Hadjigeorgiou, G. M., Anastasopoulos, I., Sansone, V., Rotondo, G., Meola, G., Rigoletto, C., Messina, S., Szwabowska-Orzeszko, E., Jozwiak, S., Michalowicz, R., Szaplyko, W., Petrella, M. A., Della Marca, G., Masullo, G., Mennuni, G. F., Kompf, D., Wascher, E., Verleger, R., Kaido, M., Soga, F., Toyooka, H., Bayon, C., Rubio, J., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Bonavita, V., Pentore, R., Venneri, A., Pasquier, F., Lebert, F., Grymonprez, L., Lefebvre, C., Van der Linden, M., Derouesné, C., Renault, B., Lacomblez, L., Homeyer, P., Ouss, L., Neuman, E., Malbezin, M., Barrandon, S., Guez, D., Stevens, M., van Swieten, J. C., Franke, C. L., Sanchez, A., Castellvirel, S., Mila, M., Jimenez, D., Pallesta, F., Ruiz, P. J. Garcia, Barrio, A., Barroso, T., Benitez, J., de Yebenes, J. Garcia, Manubens, J. M., Martinez-Lage, J. M., Larumbe, R., Muruzabal, J., Lacruz, F., Quesada, Pedro, Gallego, J., Ferini-Strambi, L., Marcone, A., Garancini, P., Tedesi, B., Jacob, B., Rozewicz, L., Langdon, D., Davie, C., Ron, M., Thompson, A., Koepp, M. J., Hansen, M. L., Guldin, B., Pressler, R. M., Ried, S., Scholz, C., Monaco, F., Gianelli, M., Schiavalla, M. P., Naldi, P., Cantello, R., Torta, R., Verze, L., Mutani, R., Knott, H., Ferbert, A., Schulze-Bonhage, A., Aust, W., Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Santacruz, P., Lopez, R., Marti, M. J., Charques, I., Catafau, A., Lomeila, F., Peila, J., Bertran, I., Blesa, R., Krendel, D. A., Costiga, D. A., Koeppen, S., Korn, W. M., Brugge, S., Schmitz, D., Scheulen, M. E., King, R. H. M., Robertson, A. M., Thomas, P. K., Kerkhofs, A., Vermersch, P., Dereeper, O., Daems Monpeun, C., Parent, M., Deplanque, D., Petit, H., Campero, M., Serra, J., Ochoa, J. L., Martinez-Matos, J. A., Montero, J., Olivé, M., Rene, R., Vidaller, A., Gugenheim, M., Gouider, R., Le Guern, E., Brice, A., Agid, Y., Bouche, P., Grisold, W., Ziflo, U., Drlicek, M., Budka, H., Jellinger, K., Zielinski, C. H., Ginsberg, L., King, R. H. M., Workman, J., Platts, A. D., Thomas, P. K., Gherardi, R. K., Florea-Strat, A., Poron, F., Sabourin, J. -C., Fazio, R., Nemni, R., Franceschi, M., Lorenzetti, I., Rinaldi, L., Canal, N., Weilbach, F. X., Sennlaub, A., Jung, S., Gold, R., Toyka, K. V., Hartung, H. P., Giegerich, G., Ellie, E., Vital, A., Steck, A. J., Vital, C., Julien, J., Doneda, P., Pizzul, S., Scarpini, E., Chiodi, P., Ramacci, M. T., Livraghi, S., Maimone, D., Annunziata, P., Salvadori, C., Guazzi, G. C., Arne-Bes, M. C., Delisle, M. B., Fabre, N., Hurtevent, J. F., Bes, A., Baudoin-Martin, D., Laborde, E., Viallet, F., Creisson, C., Crespi, V., Bogliun, G., Marzorati, L., Zincone, A., D'Angelo, L., Liberani, A., Merlini, M., Rivolta, R., Creange, A., Sabourin, J. -C., Theodorou, I., Gherardi, R. K., Conti, A. M., Malosio, M. L., Baron, P. L., Scarlato, G., Chorao, R., Rosas, M. J., Leite, I., Callea, L., Donati, E., Bargnani, C., Bud, M., Verdu, E., Navarro, X., Braun, S., Einius, S., Poindron, P., Warier, J. M., Bradley, J., Bekkelund, S. 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Martin, Fernandez, J., Mares, R., Torre, L., Mayayo, E., Lossos, A., Gomori, M., Libson, E., Goldfarb, A., Seigal, T., de Louw, A., Praamstra, P., Horstink, M., Cools, A., Tarrats, E. Basart, Calopa, M., Martinez, S., Ballabrina, J., Taussig, D., Marion, M. -H., Mallecourt, J., Ranoux, D., Gasser, T., Kabus, C., Ozelius, L., Wenzel, R., Breakefield, X. O., Boot, H., Poublon, R. M. L., Bogaard, J. M., GinaÏ, A. Z., Cabezas, C., Scholz, J., Nitschke, N., Vieregge, P., Wirk, B., Hochberg, F. H., Hefter, H., Kessler, K., Wirrwar, A., Stocklin, G., Tournier-Lasserves, E., Agundez, J. Garcia, Ruiz, E., Li, X. P., Hedlund, P. B., Fuxe, K., Kulisevsky, J., Avila, A., Berthier, M. L., Gerard, J. -M., Cambier, J., Caucheteur, C., Deuschl, G., Köster, B., Scheidt, C., Lücking, C. H., Mena, M. A., Chedru, F., Oubary, P., Rondot, P., Anagnostou, C. N., Panagopoulos, C. P., Ziogas, D. E., Vermersch, P., Robitaille, Y., Gauvreau, D., Destée, A., Delacourte, A., Ficola, U., Marozzi, P., Piccoli, F., Janelidze, M., Shakarishvili, R., Gagoshidze, T., Vashadze, T., Tsiskaridze, A., Djannelidze, M., Trullen, J. M. Perez, Pardo, P. J. Modrego, Vazquez-Andre, M. L., Bail, L., Naccache, L., Gauvrit, J. L., Panisset, M., Boller, A. F., Giannini, M., Zanette, E., Di Cesare, S., Altieri, M., Maloteaux, J. M., Delwaide, C., Sciaky, M., Newman, S. K., Kennedy, A. M., Frackowiack, R. S. J., Warrington, E. K., Rossor, M. N., Martinez-Lage, Pablo, Martinez Lage, J. Manuel, Manubens, JosÇ M., Lacruz, Francisco, Larumbe, Rosa, Muruzabal, Javier, Locatelli, T., Cursi, M., Mauri, M., Liberati, D., Fornada, C., Iriarte, L. M., Lopez, M., Grilo, A., Repeto, M., Brasic, J. R., Barnett, J. Y., Sheitman, B. B., Young, J. G., Shalit, F., Brodie, C., Sredni, B., Engelien, A., Stern, E., Huber, W., Frith, C., Miralles, F., Albadalejo, M. D., Antem, M., Pastor, I., Estelies, M. A., Del Ser, T., Ochoa, H. Severo, Munoz, D., Hachinski, V., Cucinotta, D., Senin, U., Girardello, R., Crepaldi, G., Croria, F., Schens, D. B., Vigo-Pelfrey, C., SempereE, A. P., Ortega, M. P., Bava, L., Magni, E., Aronovich, B. D., Treves, T. A., Bornstein, N. M., Van Blercom, N., Blecic, S., Violon, Ph., Hildebrand, J., Zamboni, M., Ambrosoli, L., Poli, A., Kuehnen, J., Tilgner, C., Raltzig, M., Moering, B., Faiss, J., Deeb, S. M. Al, Daif, A., Sharif, H., Tatay, J., Caroeller, F., Avendano, C., Vinogradova, T., Pinto, A. N., Canhao, P., Neau, J. -Ph., Pacquereau, J., Meurice, J. -C., Schwab, M., Bauer, R., Deeb, M. AL, Tjan, T. J., Aabed, M., Berges, S., Crepin-Leblond, T., Chavot, D., Cattin, F., Snidaro, M. H., Chopard, J. L., Ley, C. Oliveras, Alameda, F., Alfonso, S., Podobnik-Sarkanji, S., Pniewski, J., Torbicki, A., Mieszkowski, J., Plaza, I., Petrunjashev, V., Velcheva, I., Hadjiev, D., Yancheva, S., Petrov, L., Karakaneva, S., Petkov, A., Nikolov, E., Niehaus, L., Sacchetti, M. L., Toni, D., Fiorelli, M., Gori, C., Argentino, C., Lyrer, Ph., Radu, E. W., Gratzl, O., Rondepierre, Ph., Leclerc, X., Marchau, Jr, M., Scheltens, Ph., Hamon, M., Janssens, E., Henon, H., Lucas, C., KuÇukoglu, H., Baybas, S., Dervis, A., YalÇiner, B., Yilmaz, N., Ozturk, M., Arpaci, B., Navarro, J. A., Arenas, J., Perez-Sempere, A., Egido, J. A., Soriano-Soriano, C., Beau, P., Gergaud, J. -M., Coudero, C., Dierckx, R. A., Dobbeleir, A., Timmermans, E., Vandevivere, J., Lucas, C. H., Gomez, M., Aguirre, J., Berenguer, A., Duran, C., Parrilla, J., Gonzalez, F., Gironell, A., Rey, A., Marti-Vilalta, J. L., de Lecinana, M. Alonso, Federico, F., Conte, C., Simone, I. L., Giannini, P., Liguori, M., Lucivero, V., Picciola, E., Tortorella, C., Drislane, F., Wang, A. Ming, Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Levivier, M., del Olmo, A., Caballero, E., Degaey, I., de Bruijn, S. F. T. M., Tchaoussoglou, I., Bastianello, S., Pozzilli, C., Cervello, A., Catala, N., Koskas, F., Kieffer, E., Botia, E., Vivancos, J., Leon, T., Segura, T., Ramo, C., Lopez, F., Karepov, V. G., Gur, A. J., Berlanga, B., Gracia, V., Fiol, C., Kurtel, H., Ozkutlu, U., Yegen, B., Grau, A. J., Buggle, F., Heindle, S., Steichen-Wiehn, C., Banerjee, T., Maiwald, M., Becher, H., Villafana, W., Medina, F., Fernandez-Real, J. M., Soler, S., Planas, E., Iceman, E., Doganer, I., Badlan, G., Genc, B., Yulug, K., Ideman, E., Dural, H., Kutlul, K., Damalik, G., Baklan, Y., Metin, B., Tekinsoy, E., Iriarte, I., Subira, M. L., Crockar, A. D., Treacy, M., McNell, T. A., Grazzi, L., Ediboglu, N., Bilgin, H., Ertas, S., Goument, J. -P., Basset, C., Campos, Y., Garcia-Silva, T., Cabello, A., Bussaglia, E., Tizzano, E., Colomer, J., Gimbergues, P., Campagne, D., Bommelaer, C., Delaguillaume, B., Ramtami, H., Ait-Kaci-Ahmed, M., Pascual L. F., Fernandez T., Hortells M., Sanz C., Morales F., Lauritzen, L., Picard, F., Sellal, F., Collard, M., Avramidis, T., Alexiou, E., Anastopoulos, T., Frongillo, D., Delfino, F. A., Cannata, M., Calo, L., Vichi, R., Antonini, G., Fragola, V., Cannata, D., Salas, M., Ruiz, C., Angelard, B., Lacau, J., Guily, St., Sendtner, M., Goadsby, Peter J., Quin, N. P., Gadian, D. G., Roland, P. E., Seitz, Rudiger J., Frackowiak, Richard S. J., Becker, G., Krone, A., Schmidt, K., Hofmann, E., Bogdahn, U., Rosenfeld, M. R., Meneses, P., Kaplitt, M. G., Dalmau, J., Posner, J., Cordon-Cardon, C., Hoang-Xuan, K., Vega, F., Nishisho, I., Moisan, J. P., Theillet, C., Delattre, O., Zhu, Jiahong, Walther, W., Posner, J. B., Roelcke, U., von Ammon, K., Pellikka, R., Lucking, C. H., Walon, C., Boucquey, D., -Van Rijckevorsel, K. Harmant, Lannoy, N., Verellen-Dunoulin, Ch., Liszka, U., Cavaletti, G., Casati, B., Kolig, C., Bogliun, G., Marzorati, L., Johannsen, L., Chio, A., Ruda, R., Vigliani, M. C., Sciolla, R., Seliak, D., Hoang-Xuang, K., Villanueva, J. A., Montalban, X., Arboix, A., Colosimo, C., Albanese, A., Hughes, A. J., de Bruin, V., Lees, A. J., Kowalski, J. W., Banfi, S., Santoro, L., Perretti, A., Castaldo, I., Barbieri, F., Campanella, G., Bhatia, K. P., Mardsen, C. D., de Bruin, V. S., Machedo, C., Ceballos-Baumann, D., Marsden, C. D., Brooks, D. B. J., Wennlng, G. K., Quinn, N., McDonald, W. l., Warner, T. T., Bain, P. C., Davis, M. B., Conway, D., Shaunak, S., O'Sullivan, E., Crawford, T., Lawden, M., Blunt, S., Rapoport, A., Sarova-Pinchas, I., de Beyl, D. Zegers, Mavroudakis, N., Blanc, S., Godinot, C., Lenoir, G., Barkhof, M. S. F., Tas, M. W., Baron, P. L., Constantin, C., Cassatella, M. A., Langdon, D. W., Webb, S., Gasparini, P., Zeviani, A., Kidd, D., Mammi, S., Cahalon, L., Hershkoviz, R., Lahat, N., Wallach, D., Annunziata, P., Martino, T., Maimone, D., Guazzi, G. C., Porrini, A. M., Dell'Arciprete, L., Rothwell, P. M., Stewart, R. R. C., Cull, R. E., Willmes, K., Poeck, K., Russell, D., Braekken, S. K., Brucher, R., Svennevig, J., Hermesl, M., Bruckmann, H., Biraben, A., Sliwka, U., Meyer, B., Schondube, F., Noth, J., Lavenu, I., Lammers, C., Waldecker, B., Haberbosch, W., Stam, J., Schneider, R., Gautier, J. C., Berlit, T. P., Fauser, B., Kuhne, D., Geraud, G., Danielli, A., Larrue, V., Bes, A., Timmerman, E., Bono, F., Bruni, A. C., Valalentino, P., Montesi, M. P., Talerico, G., Zappia, M., Sabatelli, M., Quattrone, A., Pareyson, D., Lorenzetti, D., Sghirlanzoni, A., Castellotti, B., Lupski, J. R., Archidiacono, N., Antonacci, R., Marzella, R., Rocchi, M., Samuel, D., Goulon-Goeau, C., Costa, P. P., Bismuth, H., Said, G., De Jongh P., Lofgren A., Timmerman V., Vance J. M., Van Broeckhoven C., Martin J. -J., Martinez, A. Cruz, Bort, S., Arpa, J., Misra, P., King, R. H. M., Badhia, K., Anderson, M., Caballo, A., Vichez, J., Gabriel, J. M., Erne, B., Miescher, G. C., Ulrich, J., Vital, A., Vital, C., Steck, A., Petry, K., Labatut, I., Hilmi, S., Ellie, E., Ferrini-Strambi, L., Zucconl, M., Marchettini, P., Palazzi, S., Oehlschlager, M., Pepinsky, R. B., Gemignani, F., Marbini, A., Pavesi, G., Di Vittorio, S., Manganelli, P., Mancia, D., Vermersh, P., Roche, J., Durocher, A. M., Dewailly, Ph., Dettmers, C., Fink, G., Lemon, R., Stephan, K., Passingham, D., Weder, B., Knorr, U., Huang, Y., Butterfield, D. A., Peris, M. L., Peiro, C., Pascual, A. Pascual-Leone, Bottini, G., Folnegovic-Smalc, V., Knezevic, S., Bokonjic, R., Ersmark, B., Torres, M. Gonzalez, Guiraud-Chaumeil, B., Haugaard, K., Jovicic, A., Chr, Lang, Levic, Z., Parra, C. Martinez, Ochoa, J. Patrignani, Titlbach, O., Wikkelso, C., Caparros-Lefevre, D., Debachy, B., Verier, A., Cantinho, G., Santos, A. I., Godinho, F., Bagunya, J., Roig, T., Ensenyat, A., Santiag, O., Trabucchi, H., De Leo, D., Koch, Ch., Zeumer, H., Matkovic, Z., Morris, P., Donaghy, M., Köhler, W., Kammer, T., Röther, J., Navon, R., Fontaine, B., Wu, Y., Capdevila, A., Guardiola, M. J., van Dijk, G. W., Notermans, N. C., Kruize, A. A., Kater, L., Bertelt, C., Hesse, S., Friedrich, H., Mauritz, K. -H., Giron, L. T., Watanabe, I. S., Ewing, D., Koepp, M., Lempert, T., Sander, B., Kauerz, U., Mehdorn, H. M., Hezel, J., Eickhoff, W., Kryst, T., Timsit, S., Gardeur, D., Reis, Mitermayer Galvao dos, Secor, E., Filho, A. Andrade, Silva, M. Cardoso, Santos, S. R. Silveira, Vasilaski, G., Reis, E. A. dos, Velupillai, P., Harn, D. A., Tigera, J. Garcia, Dreke, R. Martinez, Crespo, R. Piedra, Besses, C., Acin, P., Massons, J., Florensa, L., Oliveres, M., Sans-Sabrafen, J., Wicklein, E. M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
- Published
- 1994
- Full Text
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12. Marchiafava-Bignami disease with dementia: Severe cerebral metabolic depression revealed by PET
- Author
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Pappata, S., Chabriat, H., Levasseur, M., Legault-Demare, F., and Baron, J. C.
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- 1994
- Full Text
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13. A Tracer Kinetic Model for Measurement of Regional Acetylcholinesterase Activity in the Brain Using [11C]Physostigmine and PET
- Author
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Blomvist, G., primary, Tavitian, B., additional, Pappata, S., additional, Crouzel, C., additional, Jobert, A., additional, Doignon, I., additional, and Di Giamberardino, L., additional
- Published
- 2001
- Full Text
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14. Rapid measurement of regional cerebral blood flow in the baboon using15O-labelled water and dynamic positron emission tomography
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Pinard, E., Mazoyer, B., Verrey, B., Pappata, S., and Crouzel, C.
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- 1993
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15. Emerging topics and practical aspects for an appropriate use of amyloid PET in the current Italian context
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Nobili, F., Cagnin, A., Calcagni, M. L. (ORCID:0000-0002-0805-8245), Chincarini, A., Guerra, U. P., Morbelli, S., Padovani, A., Paghera, B., Pappata, S., Parnetti, L., Sestini, S., Schillaci, O., Nobili, F., Cagnin, A., Calcagni, M. L. (ORCID:0000-0002-0805-8245), Chincarini, A., Guerra, U. P., Morbelli, S., Padovani, A., Paghera, B., Pappata, S., Parnetti, L., Sestini, S., and Schillaci, O.
- Abstract
In May 2017 some representatives of the Italian nuclear medicine and neurological communities spontaneously met to discuss the issues emerged during the first two years of routine application of amyloid PET with fluorinated radiopharmaceuticals in the real world. The limitations of a binary classification of scans, the possibility to obtain early images as a surrogate marker of regional cerebral bloos flow, the need for (semi-)quantification and, thus, the opportunity of ranking brain amyloidosis, the correlation with Aβ42 levels in the cerebrospinal fluid, the occurrence and biological meaning of uncertain/boderline scans, the issue of incidental amyloidosis, the technical pittfalls leading to false negative/positive results, the position of the tool in the diagnostic flow-chart in the national reality, are the main topics that have been discussed. Also, a card to justify the examination to be filled by the dementia specialist and a card for the nuclear medicine physician to report the exam in detail have been approved and are available in the web, which should facilitate the creation of a national register, as previewed by the 2015 intersocietal recom-mendation on the use of amyloid PET in Italy. The content of this discussion could stimulate both public institutions and companies to support further research on these topics.
- Published
- 2019
16. The role of molecular imaging in the frame of the revised dementia with Lewy body criteria
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Sestini, S., Alongi, P., Berti, V., Calcagni, Maria Lucia, Cecchin, D., Chiaravalloti, A., Chincarini, A., Cistaro, A., Guerra, U. P., Pappata, S., Tiraboschi, P., Nobili, Raffaele, Calcagni M. L. (ORCID:0000-0002-0805-8245), Nobili F., Sestini, S., Alongi, P., Berti, V., Calcagni, Maria Lucia, Cecchin, D., Chiaravalloti, A., Chincarini, A., Cistaro, A., Guerra, U. P., Pappata, S., Tiraboschi, P., Nobili, Raffaele, Calcagni M. L. (ORCID:0000-0002-0805-8245), and Nobili F.
- Abstract
Introduction: Recommendations about clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) have been recently refined by the DLB Consortium. Substantial new information has been incorporated with increased diagnostic weighting given to molecular imaging biomarkers. The present work attempted to present a comprehensive evaluation of the role of molecular imaging in the frame of the revised DLB criteria. Methods: To this end, we briefly review the molecular imaging tools in the fourth Consensus report of the DLB Consortium, highlighting several indicative and supportive surrogate markers, including I-123 brain dopamine transporter (DaT), I-123 mIBG cardiac norepinephrine transporter (NeT) and brain F-18 fluorodeoxyglucose (FDG) imaging, as the main way to increase accuracy of ante-mortem diagnosis of probable or possible DLB. Results: Along with main neuropathological and clinical issues, we focus on the diagnostic performance and appropriate use of current available items included in the index by nuclear medicine physicians, namely a low DaT uptake, a low NeT expression in myocardial tissue, and reduced parieto-occipital metabolism on brain FDG-PET. Moreover, a critical summary of the current state of the art in pathological validation of other biomarkers including amyloid and tau-PET imaging is provided. Discussion: DLB Consortium clearly states that clinical diagnosis in clinical routine is suboptimal and gives more weight to molecular imaging biomarkers to offer a more objective information. Along with DaT, mIBG and FDG techniques, brain PET with more specific radiotracers could open a new scenario for an accurate evaluation of biomarkers involved in DLB.
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- 2019
17. Paracingulate sulcus morphology in men with early-onset schizophrenia
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LE PROVOST, J.-B., BARTRÉS-FAZ, D., PAILLÈRE-MARTINOT, M.-L., ARTIGES, E., PAPPATA, S., RECASENS, C., PÉREZ-GÓMEZ, M., BERNARDO, M., BAEZA, I., BAYLE, F., and MARTINOT, J.-L.
- Published
- 2003
18. Diffusion Tensor Imaging Study of Subcortical Gray Matter in CADASIL
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Molko, N., Pappata, S., Mangin, J.F., Poupon, C., Vahedi, K., Jobert, A., LeBihan, D., Bousser, M.G., and Chabriat, H.
- Published
- 2001
19. Cerebral Hemodynamics in CADASIL Before and After Acetazolamide Challenge Assessed With MRI Bolus Tracking
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Chabriat, H., Pappata, S., Ostergaard, L., Clark, C. A., Pachot-Clouard, M., Vahedi, K., Jobert, A., Le Bihan, D., and Bousser, M. G.
- Published
- 2000
20. Clinical Severity in CADASIL Related to Ultrastructural Damage in White Matter: In Vivo Study With Diffusion Tensor MRI
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Chabriat, H., Pappata, S., Poupon, C., Clark, C. A., Vahedi, K., Poupon, F., Mangin, J. F., Pachot-Clouard, M., Jobert, A., Le Bihan, D., and Bousser, M.-G.
- Published
- 1999
21. In Vivo Detection of Striatal Dopamine Release during Reward: A PET Study with [ 11C]Raclopride and a Single Dynamic Scan Approach
- Author
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Pappata, S., Dehaene, S., Poline, J.B., Gregoire, M.C., Jobert, A., Delforge, J., Frouin, V., Bottlaender, M., Dolle, F., Di Giamberardino, L., and Syrota, A.
- Published
- 2002
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22. In Vivo Imaging of Human Cerebral Acetylcholinesterase
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Pappata, S., Tavitian, B., Traykov, L., Jobert, A., Dalger, A., Mangin, J. F., Crouzel, C., and Di Giamberardino, L.
- Published
- 1996
23. Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A Positron Emission Tomography Study in Two Affected Family Members
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Chabriat, H., Bousser, M.-G., and Pappata, S.
- Published
- 1995
24. PET Study of Changes in Local Brain Hemodynamics and Oxygen Metabolism after Unilateral Middle Cerebral Artery Occlusion in Baboons
- Author
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Pappata, S., Fiorelli, M., Rommel, T., Hartmann, A., Dettmers, C., Yamaguchi, T., Chabriat, H., Poline, J. B., Crouzel, C., Di Giamberardino, L., and Baron, J. C.
- Published
- 1993
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25. The need for standardization and larger clinical studies in emerging indications to [18F]FDG PET brain PET: autoimmune encephalitis
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Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Saraf LJ, Lammertsma A, Law I, Mathews D, Minoshima S, Moshi K, Pagani M, Pappata' S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, and Barthel H
- Subjects
PET ,Autoimmune Encephalitis - Published
- 2017
26. Effects of Capsular or Thalamic Stroke on Metabolism in the Cortex and Cerebellum: A Positron Tomography Study
- Author
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Pappata, S., Mazoyer, B., Dinh, S. Tran, Cambon, H., Levasseur, M., and Baron, J. C.
- Published
- 1990
27. Non-motor symptoms and cardiac innervation in SYNJ1-related parkinsonism
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De Rosa, A., Pellegrino, T., Pappatà, S., Lieto, M., Bonifati, V., Palma, V., Topa, A., Santoro, L., Bilo, L., Cuocolo, A., and De Michele, G.
- Published
- 2016
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28. Movement disorders: Focus on Parkinson's disease and related disorders
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Varrone A., Pappata S., and Quarantelli M.
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Parkinson's disease ,SWOT analysis ,Movement disorders - Abstract
Varrone A, Pappatà S, Quarantelli M. Movement Disorders: Focus on Parkinson's Disease and Related Disorders. in A. Ciarmiello and L. Mansi Eds.: PET-CT and PET-MRI in Neurology (SWOT Analysis Applied to Hybrid Imaging). Springer International Publishing, Switzerland, 2016. ISBN: 978-3-319-31614-7 pp103-125
- Published
- 2016
29. Preserved cortical GABA/benzodiazepin receptors and reduced rCBF in mild cognitive impairment: a single-photon-emission computed tomography study with 123-iomazenil and 99mTc-HMPAO
- Author
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PAPPATA' S., VARRONE A., VICIDOMINI V., MILAN G., DE FALCO C., SANSONE V., IAVARONE A., COMMERCI M., LORE' E., PANICO M. R., QUARANTELLI M., SALVATORE, MARCO, POSTIGLIONE, ALFREDO, Pappata', S., Varrone, A., Vicidomini, V., Milan, G., DE FALCO, C., Sansone, V., Iavarone, A., Commerci, M., Lore', E., Panico, M. R., Quarantelli, M., Salvatore, Marco, and Postiglione, Alfredo
- Subjects
mild cognitive impairment ,SPECT ,Alzheimer - Published
- 2010
30. Worldwide distribution for the PSEN1 Met46Leu founder mutation: a large variability for a founder mutation
- Author
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BRUNI A. M., BERNARDI R., COLAO R., RUBINO E., SMIRNE N., FRANGIPANE F., TERNI B., CURCIO S. A. M., MIRABELLI M., CLODOMIRO A., DiLORENZO R., MALETTA R., ANFOSSI M., GALLO M., GERACITANO S., TOMAINO C., MURACA M. G., LEOTTA A., LIO S. G., PINESSI L., RAINERO I., SORBI S., NEE L., MILAN G., PAPPATA' S., ABBAMONDI N., FORLONI G., S.t. GEORGE HYSLOP P., ROGAEVA E., BUGIANI O., GIACCONE G., FONCIN J. F., SPILLANTINI M. G., PUCCIO G. F., POSTIGLIONE, ALFREDO, Bruni, A. M., Bernardi, R., Colao, R., Rubino, E., Smirne, N., Frangipane, F., Terni, B., Curcio, S. A. M., Mirabelli, M., Clodomiro, A., Dilorenzo, R., Maletta, R., Anfossi, M., Gallo, M., Geracitano, S., Tomaino, C., Muraca, M. G., Leotta, A., Lio, S. G., Pinessi, L., Rainero, I., Sorbi, S., Nee, L., Milan, G., Pappata', S., Postiglione, Alfredo, Abbamondi, N., Forloni, G., S. t. GEORGE HYSLOP, P., Rogaeva, E., Bugiani, O., Giaccone, G., Foncin, J. F., Spillantini, M. G., and Puccio, G. F.
- Subjects
Alzheimer ,genetica ,dementia - Abstract
OBJECTIVE: Large kindreds segregating familial Alzheimer disease (FAD) offer the opportunity of studying clinical variability as observed for presenilin 1 (PSEN1) mutations. Two early-onset FAD (EOFAD) Calabrian families with PSEN1 Met146Leu (ATG/CTG) mutation constitute a unique population descending from a remote common ancestor. Recently, several other EOFAD families with the same mutation have been described worldwide. METHODS: We searched for a common founder of the PSEN1 Met146Leu mutation in families with different geographic origins by genealogic and molecular analyses. We also investigated the phenotypic variability at onset in a group of 50 patients (mean age at onset 40.0 +/- 4.8 years) by clinical, neuropsychological, and molecular methodologies. RESULTS: EOFAD Met146Leu families from around the world resulted to be related and constitute a single kindred originating from Southern Italy before the 17th century. Phenotypic variability at onset is broad: 4 different clinical presentations may be recognized, 2 classic for AD (memory deficits and spatial and temporal disorientation), whereas the others are expressions of frontal impairment. The apathetic and dysexecutive subgroups could be related to orbital-medial prefrontal cortex and dorsolateral prefrontal cortex dysfunction. CONCLUSIONS: Genealogic and molecular findings provided evidence that the PSEN1 Met146Leu families from around the world analyzed in this study are related and represent a single kindred originating from Southern Italy. The marked phenotypic variability might reflect early involvement by the pathologic process of different cortical areas. Although the clinical phenotype is quite variable, the neuropathologic and biochemical characteristics of the lesions account for neurodegenerative processes unmistakably of Alzheimer nature.
- Published
- 2010
31. Fronto-temporal dementia
- Author
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POSTIGLIONE, ALFREDO, MILAN G., PAPPATA' S., SUN M.K., Postiglione, Alfredo, Milan, G., and Pappata', S.
- Subjects
genetics ,fronto-temporal dementia ,dementia - Published
- 2009
32. Early-onset Parkinsonism caused by SYNJ1 p.Arg258Gln homozygous mutation in a new Italian family
- Author
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Olgiati, S., De Rosa, A., Quadri, M., Criscuolo, C., Breedveld, G. J., Picillo, M., Graafland, J., Pappata, S., Quarantelli, M., Barone, P., De Michele, G., and Bonifati, V.
- Subjects
Parkinsonism ,MRI - Published
- 2014
33. Body image distortion in eating disorders: a high temporal resolution neuroimaging study
- Author
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VOLPE, Umberto, GALDERISI, Silvana, PAPPATA S, PRINSTER A, MUCCI, Armida, MOLLICA C, CASTALDO E, ALFANO B, MAJ M., WCCBT, Volpe, Umberto, Galderisi, Silvana, Pappata, S, Prinster, A, Mucci, Armida, Mollica, C, Castaldo, E, Alfano, B, and Maj, M.
- Published
- 2007
34. SPINOCEREBELLAR ATAXIA 2: A BRAIN DIFFUSION-WEIGHTED MRI STUDY
- Author
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SALVATORE, ELENA, MOLLICA C, IANNICIELLO M, VARRONE A, SANSONE V, SALVATORE M, FILLA, ALESSANDRO, PAPPATA S., DE MICHELE, GIUSEPPE, Salvatore, Elena, Mollica, C, Ianniciello, M, Varrone, A, Sansone, V, Salvatore, M, DE MICHELE, Giuseppe, Filla, Alessandro, and Pappata, S.
- Published
- 2006
35. Remote metabolic effects of cerebrovascular lesions: magnetic resonance and positron tomography imaging
- Author
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Pappata, S., Tran Dinh, S., Baron, J. C., Cambon, H., and Syrota, A.
- Published
- 1987
- Full Text
- View/download PDF
36. Effects of Thyroid Blockade on Brain Imaging of Dopamine Transporter in Normal Mice
- Author
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Greco, A., Zannetti, A., Coda, A. R. D., Albanese, S., Nardelli, A., Roca, A., Pappata, S., Brunetti, A., and Cuocolo, A.
- Published
- 2013
37. Voxel-based comparison of rCBF SPET images in frontotemporal dementia an Alzheimer's dementia highlights the involvment of different cortical networks
- Author
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VARRONE A, PAPPATA' S, CARACO' C, SORICELLI A, MILAN G, QUARANTELLI M, ALFANO B, SALVATORE M., POSTIGLIONE, ALFREDO, Varrone, A, Pappata', S, Caraco', C, Soricelli, A, Milan, G, Quarantelli, M, Alfano, B, Postiglione, Alfredo, and Salvatore, M.
- Published
- 2002
38. PARK20 caused by SYNJ1 homozygous Arg258Gln mutation in a new Italian family
- Author
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Olgiati, Simone, De Rosa, A, Quadri, Marialuisa, Criscuolo, Chiara, Breedveld, Guido, Picillo, M, Pappata, S, Quarantelli, M, Barone, P, de Michele, G, Bonifati, Vincenzo, Olgiati, Simone, De Rosa, A, Quadri, Marialuisa, Criscuolo, Chiara, Breedveld, Guido, Picillo, M, Pappata, S, Quarantelli, M, Barone, P, de Michele, G, and Bonifati, Vincenzo
- Abstract
SYNJ1 has been recently identified by two independent groups as the gene defective in a novel form of autosomal recessive, early-onset atypical parkinsonism (PARK20). Two consanguineous families were initially reported (one of Sicilian and one of Iranian origins), with the same SYNJ1 homozygous mutation (c.773G > A, p.Arg258Gln) segregating with a similar phenotype of early-onset parkinsonism and additional atypical features. Here, we report the identification of the same SYNJ1 homozygous mutation in two affected siblings of a third pedigree. Both siblings had mild developmental psychomotor delay, followed, during the third decade of life, by progressive parkinsonism, dystonia, and mild cognitive impairment. One sibling suffered one episode of generalized seizures. Neuroimaging studies revealed severe nigrostriatal dopaminergic defects, mild striatal and very mild cortical hypometabolism. Treatment with dopamine agonists and anticholinergics resulted in partial improvements. Genetic analyses revealed in both siblings the SYNJ1 homozygous c.773G > A (p.Arg258Gln) mutation. Haplotype analysis suggests that the mutation has arisen independently in this family and the Sicilian PARK20 family previously described by us, in keeping with the hypothesis of a mutational hot spot. This is the third reported family with autosomal recessive, early-onset parkinsonism associated with the SYNJ1 p.Arg258Gln mutation. This work contributes to the definition of the genetic and clinical aspects of PARK20. This newly recognized form must be considered in the diagnostic work-up of patients with early-onset atypical parkinsonism. The presence of seizures might represent a red flag to suspect PARK20.
- Published
- 2014
39. New SPECT and PET dementia tracers
- Author
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Vergote, J, Chalon, S, Emond, P, Vercouillie, J, Pappata, S, and Guilloteau, D
- Published
- 2009
40. Two Novel CYP7131 Mutations in Italian Families with Autosomal Recessive Spastic Paraplegia: A Clinical and Genetic Study
- Author
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Criscuolo, C, Filla, A, Coppola, G, Rinaldi, C, Carbone, R, Pinto, S, Wang, Q, De Leua, MF, Salvatore, E, Quarantelli, M, Geschwind, D, Pappata, S, and De Michele, G
- Published
- 2009
- Full Text
- View/download PDF
41. Co-existence of primary hyperparathyroidism and Parkinson’s disease in three patients: An incidental finding?
- Author
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De Rosa, A., Rinaldi, C., Tucci, T., Pappatà, S., Rossi, F., Morra, V. Brescia, Faggiano, A., Colao, A., and De Michele, G.
- Published
- 2011
- Full Text
- View/download PDF
42. Neuroimaging follow-up in a case of Rasmussen's encephalitis with dyskinesias
- Author
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de Leva MF, Varrone A, Filla A, Quarantelli M, Bilo L, Piscitelli V, Salvatore E, Ammendola S, Striano S, de Michele G, Bonavita V, and Pappata S.
- Abstract
We describe a case of adult-onset biphasic Rasmussen's encephalitis who presented seizures and left dyskinesias at the onset and, after 1 year, language disorder. Serial MRI and [(18)F] FDG-PET scans were performed showing involvement of the right cerebral hemisphere in the first phase and of the contralateral one in the second.
- Published
- 2007
43. Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts
- Author
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Buffon F, Molko N, Hervé D, Porcher R, Denghien I, Pappata S, Le Bihan D, Bousser MG, and Chabriat H.
- Subjects
nervous system - Abstract
Diffusion tensor imaging can be used in vivo to assess the longitudinal and regional microstructural changes occurring after middle cerebral artery (MCA) infarcts in humans. Nine patients were investigated 1 week (D7), 1 (M1), 3 (M3), and 6 months (M6) after the occurrence of an isolated MCA infarction. First, an overall analysis was performed using histograms of mean diffusivity (MD) and fractional anisotropy (FA) in each hemisphere. Thereafter, the regional pattern of diffusion changes was investigated voxel by voxel with statistical parametric mapping 99. In the hemisphere ipsilateral to the infarction, histogram analysis revealed a significant decrease in FA between D7 and M6 associated with a progressive increase in MD from D7 to M3. Remote from the MCA territory, the voxel by voxel analyses detected a significant increase in MD within the thalamus at M3 and M6 and a reduction in FA along the pyramidal tract at M6. In the contralateral hemisphere, between D7 and M6, a significant hemispheric atrophy was observed in association with a global reduction in anisotropy, in the absence of distinctive regional diffusion changes. These results suggest that micro- and macrostructural tissue modifications can be detected with diffusion tensor imaging in regions remote from the ischemic area in both hemispheres.
- Published
- 2005
44. Paracingulate sulcus morphology in men with early-onset schizophrenia
- Author
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Le Provost JB, Bartres-Faz D, Paillere-Martinot ML, Artiges E, Pappata S, Recasens C, Perez-Gomez M, Bernardo M, Baeza I, Bayle F, and Martinot JL
- Subjects
behavioral disciplines and activities ,humanities - Abstract
BACKGROUND: Cingulate dysfunction has been reported in schizophrenia. Although the paracingulate sulcus (PCS) is known to be asymmetric in healthy people, little information is available about its morphology in schizophrenia. AIMS: To search for morphological anomalies of the PCS in men with early-onset schizophrenia. METHOD: The PCS was examined in magnetic resonance images of the brains of men with schizophrenia and 100 healthy men. RESULTS: A significant asymmetry was found in the brains of healthy volunteers, whose sulci were more frequent and more marked in the left hemisphere. In contrast, the sulcus was as frequent in the right as in the left hemisphere in the patient group. Moreover, patients displayed significantly more rightward asymmetry, and overall less-asymmetrical patterns than the comparison group. CONCLUSIONS: Since the PCS has developed at 36 weeks of gestation, these findings suggest an impaired maturation of the cingulate region during the third trimester.
- Published
- 2003
45. Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism
- Author
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Quadri, M., Fang, M., Picillo, M., Olgiati, S., Breedveld, G.J., Graafland, J., Wu, B., Xu, F., Erro, R., Amboni, M., Pappata, S., Quarantelli, M., Annesi, G., Quattrone, A., Chien, H.F., Barbosa, E.R., Oostra, B.A., Barone, P., Wang, J, Bonifati, V., Warrenburg, B.P.C. van de, Bloem, B., Quadri, M., Fang, M., Picillo, M., Olgiati, S., Breedveld, G.J., Graafland, J., Wu, B., Xu, F., Erro, R., Amboni, M., Pappata, S., Quarantelli, M., Annesi, G., Quattrone, A., Chien, H.F., Barbosa, E.R., Oostra, B.A., Barone, P., Wang, J, Bonifati, V., Warrenburg, B.P.C. van de, and Bloem, B.
- Abstract
Item does not contain fulltext, Autosomal recessive, early-onset Parkinsonism is clinically and genetically heterogeneous. Here, we report the identification, by homozygosity mapping and exome sequencing, of a SYNJ1 homozygous mutation (p.Arg258Gln) segregating with disease in an Italian consanguineous family with Parkinsonism, dystonia, and cognitive deterioration. Response to levodopa was poor, and limited by side effects. Neuroimaging revealed brain atrophy, nigrostriatal dopaminergic defects, and cerebral hypometabolism. SYNJ1 encodes synaptojanin 1, a phosphoinositide phosphatase protein with essential roles in the postendocytic recycling of synaptic vesicles. The mutation is absent in variation databases and in ethnically matched controls, is damaging according to all prediction programs, and replaces an amino acid that is extremely conserved in the synaptojanin 1 homologues and in SAC1-like domains of other proteins. Sequencing the SYNJ1 ORF in unrelated patients revealed another heterozygous mutation (p.Ser1422Arg), predicted as damaging, in a patient who also carries a heterozygous PINK1 truncating mutation. The SYNJ1 gene is a compelling candidate for Parkinsonism; mutations in the functionally linked protein auxilin cause a similar early-onset phenotype, and other findings implicate endosomal dysfunctions in the pathogenesis. Our data delineate a novel form of human Mendelian Parkinsonism, and provide further evidence for abnormal synaptic vesicle recycling as a central theme in the pathogenesis.
- Published
- 2013
46. Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
- Author
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McNeill, A. (Alisdair), Wu, R-M. (Ruey-Meei), Tzen, K.-Y. (Kai-Yuan), Aguiar, P.C. (Patricia), Arbelo, J.M. (Jose), Barone, P. (Paolo), Bhatia, K.P. (Kailash), Barsottini, O.G. (Orlando), Bonifati, V. (Vincenzo), Bostantjopoulou, S. (Sevasti), Bressan, R.A. (Rodrigo), Cossu, G. (Giovanni), Cortelli, P. (Pietro), Felicio, A.C. (Andre), Ferraz, H.B. (Henrique), Herrera, J. (Joanna), Houlden, H. (Henry), Hoexter, M. (Marcelo), Isla, C. (Concepcion), Lees, A.J. (Andrew), Lorenzo-Betancor, O. (Oswaldo), Mencacci, N.E. (Niccolo), Pastor, P. (Pau), Pappata, S. (Sabina), Pellecchia, M.T. (Maria Teresa), Silveria-Moriyama, L. (Laura), Varrone, A. (Andrea), Foltynie, T. (Thomas), Schapira, A.H.V. (Anthony), McNeill, A. (Alisdair), Wu, R-M. (Ruey-Meei), Tzen, K.-Y. (Kai-Yuan), Aguiar, P.C. (Patricia), Arbelo, J.M. (Jose), Barone, P. (Paolo), Bhatia, K.P. (Kailash), Barsottini, O.G. (Orlando), Bonifati, V. (Vincenzo), Bostantjopoulou, S. (Sevasti), Bressan, R.A. (Rodrigo), Cossu, G. (Giovanni), Cortelli, P. (Pietro), Felicio, A.C. (Andre), Ferraz, H.B. (Henrique), Herrera, J. (Joanna), Houlden, H. (Henry), Hoexter, M. (Marcelo), Isla, C. (Concepcion), Lees, A.J. (Andrew), Lorenzo-Betancor, O. (Oswaldo), Mencacci, N.E. (Niccolo), Pastor, P. (Pau), Pappata, S. (Sabina), Pellecchia, M.T. (Maria Teresa), Silveria-Moriyama, L. (Laura), Varrone, A. (Andrea), Foltynie, T. (Thomas), and Schapira, A.H.V. (Anthony)
- Abstract
Objectives:To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.Methods:A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.Results:Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.Conclusions:The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
- Published
- 2013
- Full Text
- View/download PDF
47. Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
- Author
-
McNeill, A, Wu, RM, Tzen, KY, Aguiar, PC, Arbelo, JM, Barone, P, Bhatia, K, Barsottini, O, Bonifati, Vincenzo, Bostantjopoulou, S, Bressan, R, Cossu, G, Cortelli, P, Felicio, A, Ferraz, HB, Herrera, J, Houlden, H, Hoexter, M, Isla, C, Lees, A, Lorenzo-Betancor, O, Mencacci, NE, Pastor, P, Pappata, S, Pellecchia, MT, Silveria-Moriyama, L, Varrone, A, Foltynie, T, Schapira, AHV, McNeill, A, Wu, RM, Tzen, KY, Aguiar, PC, Arbelo, JM, Barone, P, Bhatia, K, Barsottini, O, Bonifati, Vincenzo, Bostantjopoulou, S, Bressan, R, Cossu, G, Cortelli, P, Felicio, A, Ferraz, HB, Herrera, J, Houlden, H, Hoexter, M, Isla, C, Lees, A, Lorenzo-Betancor, O, Mencacci, NE, Pastor, P, Pappata, S, Pellecchia, MT, Silveria-Moriyama, L, Varrone, A, Foltynie, T, and Schapira, AHV
- Abstract
Objectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease. Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right: left asymmetry index and striatal asymmetry index was calculated. Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations. Conclusions: The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
- Published
- 2013
48. Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks
- Author
-
Varrone, A, Pappata, S, Caraco, C, Soricelli, Andrea, Milan, G, and Quarantelli, M.
- Published
- 2002
49. Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability
- Author
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Santoro, L, Breedveld, Guido, Manganelli, F, Iodice, R, Pisciotta, C, Nolano, M, Punzo, Francesca, Quarantelli, M, Pappata, S, Di Fonzo, Alessio, Oostra, Ben, Bonifati, Vincenzo, Santoro, L, Breedveld, Guido, Manganelli, F, Iodice, R, Pisciotta, C, Nolano, M, Punzo, Francesca, Quarantelli, M, Pappata, S, Di Fonzo, Alessio, Oostra, Ben, and Bonifati, Vincenzo
- Abstract
Mutations in the ATP13A2 (PARK9) and FBXO7 (PARK15) genes are linked to different forms of autosomal recessive juvenile-onset neurodegenerative diseases with overlapping phenotypes, including levodopa-responsive parkinsonism, pyramidal disturbances, cognitive decline, and supranuclear gaze disturbance. However, the associated genotypes and phenotypes are poorly characterized due to the small number of patients described. Here, we report clinical, instrumental, and genetic findings in an Italian family with novel PARK9 and PARK15 mutations. The proband developed a severe progressive phenotype including juvenile-onset parkinsonism, pyramidal disturbances, cognitive decline, and oculomotor abnormalities. On the contrary, his brother only shows mild abnormalities (pyramidal, cognitive, and oculomotor) on the neurological examination at the age of 31 years. These two brothers both carry a novel homozygous PARK9 missense (p.G877R) and a novel heterozygous PARK15 mutation (p.R481C). The PARK9 mutation replaces a crucial residue for the ATPase activity, and is therefore most likely a loss-of-function mutation and disease-causing in homozygous state. The pathogenic significance of the PARK15 single heterozygous mutation remains unclear. In both sibs, DaTSCAN single photon emission computed tomography showed marked nigrostriatal dopaminergic defects, and transcranial magnetic stimulation detected prolonged central motor conduction time. MRI, including T2*-weighted imaging, detected no evidence of brain iron accumulation. This family, the third reported with homozygous PARK9 mutations and the first with mutations in two genes for atypical juvenile parkinsonism, illustrates that PARK9-linked disease might display wide intra-familial clinical variability and milder phenotypes, suggesting the existence of strong, still unknown, modifiers.
- Published
- 2011
50. Cortical control of optokinetic nystagmus in humans: a PET study
- Author
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Galati, Gaspare, Pappata, S., Pantano, P., Lenzi, G. L., Samson, Y., and Pizzamiglio, Luigi Remo
- Published
- 1999
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