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113 results on '"Pappas, Todd"'

3. Abstract B044: Serum miRNA expression in ovarian cancer patients is independent of histological subtype and FIGO stage

Author

Wollborn, Laura, primary, Webber, James W., additional, Mishra, Sudhanshu, additional, Sussman, Chad B., additional, Comrie, Cameron E., additional, Packard, Daniel G., additional, Vitonis, Allison, additional, Alimena, Stephanie, additional, Phan, Ryan, additional, Pappas, Todd, additional, Cramer, Daniel W., additional, Chowdhury, Dipanjan, additional, and Elias, Kevin M., additional

Published
2024
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10. Additional file 4 of Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples

Author

Chunxiao Fu, Marczyk, Michal, Samuels, Michael, Trevarton, Alexander J., Jiaxin Qu, Lau, Rosanna, Du, Lili, Pappas, Todd, Sinn, Bruno V., Gould, Rebekah E., Pusztai, Lajos, Hatzis, Christos, and Symmans, W. Fraser

Abstract

Additional File 4: Fig. S4. Concordance between wtRNAseq and targeted RNAseq of gene expression levels and transcriptional signature scores. Distribution of Pearson correlation (Rho), bias, scale and location coefficient (components of concordance correlation coefficient (CCC)) for all 28 targeted genes within each protocol. The green points represent the two transcriptional signatures.

Published
2021
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11. Additional file 1 of Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples

Author

Chunxiao Fu, Marczyk, Michal, Samuels, Michael, Trevarton, Alexander J., Jiaxin Qu, Lau, Rosanna, Du, Lili, Pappas, Todd, Sinn, Bruno V., Gould, Rebekah E., Pusztai, Lajos, Hatzis, Christos, and Symmans, W. Fraser

Abstract

Additional file 1: Fig. S1. Technical variance of expression measurements in targeted RNAseq data using FF samples. (A) Distribution of absolute difference in expression between replicates for 28 targeted genes within each protocol. (B) Distribution of absolute difference in molecular signature score between replicates for 2 signatures within each protocol.

Published
2021
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12. Additional file 3 of Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples

Author

Chunxiao Fu, Marczyk, Michal, Samuels, Michael, Trevarton, Alexander J., Jiaxin Qu, Lau, Rosanna, Du, Lili, Pappas, Todd, Sinn, Bruno V., Gould, Rebekah E., Pusztai, Lajos, Hatzis, Christos, and Symmans, W. Fraser

Abstract

Additional File 3: Fig. S3. Distribution of raw read depth across all gene targets in FFPE samples. Line type (solid or dashed) distinguishes two technical replicates, while color represents different protocol. Genes are sorted by average read depth in all samples.

Published
2021
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13. Additional file 2 of Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples

Author

Chunxiao Fu, Marczyk, Michal, Samuels, Michael, Trevarton, Alexander J., Jiaxin Qu, Lau, Rosanna, Du, Lili, Pappas, Todd, Sinn, Bruno V., Gould, Rebekah E., Pusztai, Lajos, Hatzis, Christos, and Symmans, W. Fraser

Abstract

Additional File 2: Fig. S2. Distribution of raw read depth across all gene targets in FF samples. Line type (solid or dashed) distinguishes two technical replicates (6 samples have only 1 replicate in FF), while color represents different protocol. Genes are sorted by average read depth in all samples.

Published
2021
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17. Unique temperature-activated neurons from pit viper thermosensors

Author

Pappas, Todd C., Motamedi, Massoud, and Christensen, Burgess N.

Subjects
Snakes -- Research, Neurons -- Research, Biological sciences
Abstract

Unique temperature-activated neurons from pit viper thermosensors. Am J Physiol Cell Physiol 287: C1219-C1228, 2004. First published June 22, 2004; doi:10.1152/ajpcell.00040.2004.--Rattlesnakes, copperheads, and other pit vipers have highly sensitive heat detectors known as pit organs, which are used to sense and strike at prey. However, it is not currently known how temperature change triggers cellular and molecular events that activate neurons supplying the pit organ. We dissociated and cultured neurons from the trigeminal ganglia (TG) innervating the pit organs of the Western Diamondback rattlesnake (Crotalus atrox) and the copperhead (Agkistrodon contortix) to investigate electrophysiological responses to thermal stimuli. Whole cell voltage-clamp recordings indicated that 75% of the TG neurons from C. atrox and 74% of the TG neurons from A. contortix showed a unique temperature-activated inward current ([I.sub.[DELTA]T]). We also found an [I.sub.[DELTA]T]-like current in 15% of TG neurons from the common garter snake, a species that does not have a specialized heat-sensing organ. A steep rise in the current-temperature relationship of [I.sub.[DELTA]T] started just below 18[degrees]C, and cooling temperature-responsive TG neurons from 20[degrees]C resulted in an outward current, suggesting that [I.sub.[DELTA]T] is on at relatively low temperatures, ion substitution and [Ca.sup.2+] imaging experiments indicated that [I.sub.[DELTA]T] is primarily a monovalent cation current. [I.sub.[DELTA]T] was not sensitive to capsaicin or amiloride, suggesting that the current did not show similar pharmacology to other mammalian heat-sensitive membrane proteins. Our findings indicate that a novel temperature-sensitive conductance with unique ion permeability and low-temperature threshold is expressed in TG neurons and may be involved in highly sensitive heat detection in snakes. snake; thermosensory; trigeminal; ion conductance

Published
2004

20. Rapid Anti-Depressant Relief by Ketamine: Exploring A Complex Mechanism of Action

Author

Blum, Kenneth, primary, Pappas, Todd C., additional, Clifton, Bryan, additional, Baron, David, additional, Madigan, Margaret A., additional, Lott, Lisa, additional, Moran, Mark, additional, Clifton, Cannon, additional, Worrich, Scott, additional, Clarke, Ervey, additional, Boyett, Brent, additional, Bowirrat, Abdalla, additional, and Gold, Mark S., additional

Published
2019
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21. Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CDCR4

Author

Herbein, Georges, Mahiknecht, Ulrich, Batliwalla, Franak, Gregersen, Peter, Pappas, Todd, Butler, John, O'Brien, William A., and Verdin, Eric

Subjects
Cell death -- Research, Macrophages -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

CD8-positive T cells are believed to be important in control of infection by human immunodeficiency virus (HIV) due to their cytotoxic activity. It is reported that the death rate of CD8+ T cells by apoptosis showed marked increase during HIV infection of peripheral blood mononuclear cells in vitro. Apoptosis is mediated by interaction of tumour-necrosis factor-alpha bound to the membrane of macrophages, with a receptor on CD8+ T cells.

Published
1998

23. Circulating hyaluronan levels in the rodent: effects of age and diet

Author

Yannariello-Brown, Judith, Chapman, Shirley H., Ward, Walter F., Pappas, Todd C., and Weigel, Paul H.

Subjects
Serum -- Research, Food -- Caloric content, Biological sciences
Abstract

The examination of circulating hyaluronan (HA) levels as a function of age and diet in Fischer 344 male rats, provides a biphasic pattern of age-related changes in rats fed at will a diet with soya as the protein source. The HA levels were also determined in rats fed at will a semisynthetic diet with hydrolyzed casein as the protein source. Both the groups showed identical biphasic age related changes. The findings indicate that HA turnover and metabolism in the rat are influenced by age, diet and calorie intake.

Published
1995

26. Clinical correlates of body-size distortion

Author

Pumariga, Andres J., Black, Sandra A., Gustavson, Carl R., Gustavson, Joan C., Gustavson, Andrew R., Reinarz, Dianne, Probe, Lanell, and Pappas, Todd

Subjects
Body size -- Psychological aspects, Eating disorders -- Psychological aspects, Health, Psychology and mental health
Published
1993

27. Body-image distortion among male and female college and high school students, and eating-disordered patients

Author

Pumariega, Andres J., Reinarz, Diane E., Gustavson, Carl R., Gustavson, Joan C., Dameron, Rachel, Pappas, Todd, McCaul, Kevin, and Gustavson, Andrew R.

Subjects
College students -- Health aspects, Eating disorders -- Psychological aspects, High school students -- Health aspects, Body image -- Psychological aspects, Self-perception in adolescence -- Research, Health, Psychology and mental health
Abstract

Summary.--For 179 male and female college and high school students, and 26 female eating-disordered patients body-image distortion was measured using a computer-based image-analysis of redrawn images of standardized human figures. Statistical analysis indicated that body-image distortion was the same for all groups. Body-image distortion was significantly and negatively related to weight:height ratio as a function of a simple polynomial. These results suggest this evaluation of distortion of body-image yields a quantitative measure reliably related to weight status but also suggests the technique, and possibly measurement of body-image distortion in general, may not be a valid discriminator between eating-disordered and normal persons.

Published
1990

41. Potential Role for CD63 in CCR5-Mediated Human Immunodeficiency Virus Type 1 Infection of Macrophages

Author

von Lindern, Jana J., primary, Rojo, Daniel, additional, Grovit-Ferbas, Kathie, additional, Yeramian, Christine, additional, Deng, Cheng, additional, Herbein, Georges, additional, Ferguson, Monique R., additional, Pappas, Todd C., additional, Decker, Julie M., additional, Singh, Anjali, additional, Collman, Ronald G., additional, and O'Brien, William A., additional

Published
2003
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47. Clinical Correlates of Body-Size Distortion

Author

Pumariega, Andrés J., primary, Gustavson, Carl R., additional, Gustavson, Joan C., additional, Black, Sandra A., additional, Gustavson, Andrew R., additional, Reinarz, Dianne, additional, Probe, Lanelle, additional, and Pappas, Todd, additional

Published
1993
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49. Apoptosis of CD8+T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.

Author

Herbein, Georges, Mahlknecht, Ulrich, Batliwalla, Franak, Gregersen, Peter, Pappas, Todd, Butler, John, O'Brien, William A., and Verdin, Eric

Subjects
APOPTOSIS, HIV, MACROPHAGES, CD antigens
Abstract

Reports that the death rate of CD8-positive T cells by apoptosis increased markedly during HIV infection of peripheral blocks mononuclear cells in vitro. How apoptosis of CD8+ T cells isolated from HIV-infected patients is also mediated by macrophages through the interaction between mbTNF and TNFRII; Results.

Published
1998
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