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369 results on '"Pappas, Lisa"'

1. Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients

Author

Sample, Danielle C, Samadder, N Jewel, Pappas, Lisa M, Boucher, Kenneth M, Samowitz, Wade S, Berry, Therese, Westover, Michelle, Nathan, Deepika, Kanth, Priyanka, Byrne, Kathryn R, Burt, Randall W, and Neklason, Deborah W

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Genetics, Rare Diseases, Prevention, Cancer, Clinical Research, Colo-Rectal Cancer, Adenomatous Polyposis Coli, Adolescent, Adult, Age Factors, Aged, Colectomy, Duodenal Neoplasms, Endoscopy, Gastrointestinal, Female, Genes, APC, Humans, Intestinal Polyps, Male, Middle Aged, Mutation, Penetrance, Phenotype, Prospective Studies, Sex Factors, Stomach Neoplasms, Young Adult, Duodenum, Gastric, Polyposis, Familial adenomatous polyposis, Fundic gland polyps, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundPatients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the duodenal and gastric polyp phenotype in a cohort of 150 FAP patients undergoing pre-screening for a chemoprevention trial and analyze variables that may affect recommendations for surveillance.MethodsIndividuals with a diagnosis of FAP underwent prospective esophagogastroduodenoscopy using a uniform system of mapping of size and number of duodenal polyps for a 10 cm segment. Gastric polyps were recorded as the total number.ResultsThe distribution of the count and sum diameter of duodenal polyps were statistically different in two genotype groups, those with APC mutations associated with classic FAP had a greater count (median 17) and sum diameter of polyps (median 32 mm) than those with APC mutations associated with attenuated FAP (median count 4 and median sum diameter of 7 mm) (p

Published
2018

5. Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled in a tai chi chih randomized controlled trial

Author

Campo, Rebecca A, Light, Kathleen C, O’Connor, Kathleen, Nakamura, Yoshio, Lipschitz, David, LaStayo, Paul C, Pappas, Lisa M, Boucher, Kenneth M, Irwin, Michael R, Hill, Harry R, Martins, Thomas B, Agarwal, Neeraj, and Kinney, Anita Y

Subjects
Aging, Clinical Trials and Supportive Activities, Rehabilitation, Cancer, Prevention, Mind and Body, Clinical Research, Cardiovascular, Complementary and Integrative Health, Good Health and Well Being, Aged, Aged, 80 and over, Blood Pressure, Cytokines, Female, Humans, Hydrocortisone, Inflammation, Middle Aged, Neoplasms, Survivors, Tai Ji, Treatment Outcome, Senior cancer survivors, Tai Chi Chih, Randomized controlled trial, Blood pressure, Cortisol, Inflammatory cytokines, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

PurposeOlder cancer survivors are a vulnerable population due to an increased risk for chronic diseases (e.g., cardiovascular disease) compounded with treatment late-effects and declines in physical functioning. Therefore, interventions that reduce chronic disease risk factors (i.e., blood pressure, chronic inflammation, and cortisol) are important in this population. Tai chi chih (TCC) is a mind-body exercise associated with reductions in chronic disease risk factors, but has not been examined with older cancer survivors. In a feasibility randomized controlled trial of TCC, we examined secondary outcomes of blood pressure, salivary cortisol, and inflammatory cytokines (interleukin (IL)-6, IL-12, tumor necrosis factor-α, IL-10, IL-4) due to their implications in chronic diseases.MethodsSixty-three senior female cancer survivors (M age = 67 years, SD = 7.15) with physical functioning limitations (SF-12 physical functioning ≤80 or role-physical ≤72) were randomized to 12-weeks (60-min, three times a week) of TCC or Health Education control (HEC) classes. Resting blood pressure, 1-day salivary cortisol samples, and fasting plasma samples for cytokine multiplex assays were collected at baseline and 1-week post-intervention.ResultsControlling for baseline values, the TCC group had significantly lower systolic blood pressure (SBP, p = 0.002) and cortisol area-under-curve (AUC, p = 0.02) at post-intervention than the HEC group. There was no intervention effect on inflammatory cytokines (p's > 0.05).ConclusionsThis TCC feasibility trial was associated with significant reductions in SBP and cortisol AUC in senior female cancer survivors. Larger, definitive trials are needed to confirm these findings.Implications for cancer survivorsSenior survivors' have an increased risk for chronic diseases; however, TCC interventions may help reduce associated risk factors.

Published
2015

9. A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

Author

Drost, Mark, Tiersma, Yvonne, Thompson, Bryony A., Frederiksen, Jane H., Keijzers, Guido, Glubb, Dylan, Kathe, Scott, Osinga, Jan, Westers, Helga, Pappas, Lisa, Boucher, Kenneth M., Molenkamp, Siska, Zonneveld, José B., van Asperen, Christi J., Goldgar, David E., Wallace, Susan S., Sijmons, Rolf H., Spurdle, Amanda B., Rasmussen, Lene J., Greenblatt, Marc S., de Wind, Niels, and Tavtigian, Sean V.

Published
2019
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11. Supplemental figure 4 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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12. Supplemental Figure 2 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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13. Supplementary Table S4 from Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia

Author

Delker, Don A., primary, Wood, Austin C., primary, Snow, Angela K., primary, Samadder, N. Jewel, primary, Samowitz, Wade S., primary, Affolter, Kajsa E., primary, Boucher, Kenneth M., primary, Pappas, Lisa M., primary, Stijleman, Inge J., primary, Kanth, Priyanka, primary, Byrne, Kathryn R., primary, Burt, Randall W., primary, Bernard, Philip S., primary, and Neklason, Deborah W., primary

Published
2023
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14. Supplemental Table 2 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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15. Supplemental Figure 3 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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16. Data from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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17. Data from Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia

Author

Delker, Don A., primary, Wood, Austin C., primary, Snow, Angela K., primary, Samadder, N. Jewel, primary, Samowitz, Wade S., primary, Affolter, Kajsa E., primary, Boucher, Kenneth M., primary, Pappas, Lisa M., primary, Stijleman, Inge J., primary, Kanth, Priyanka, primary, Byrne, Kathryn R., primary, Burt, Randall W., primary, Bernard, Philip S., primary, and Neklason, Deborah W., primary

Published
2023
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18. Supplementary Figure S2 from Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia

Author

Delker, Don A., primary, Wood, Austin C., primary, Snow, Angela K., primary, Samadder, N. Jewel, primary, Samowitz, Wade S., primary, Affolter, Kajsa E., primary, Boucher, Kenneth M., primary, Pappas, Lisa M., primary, Stijleman, Inge J., primary, Kanth, Priyanka, primary, Byrne, Kathryn R., primary, Burt, Randall W., primary, Bernard, Philip S., primary, and Neklason, Deborah W., primary

Published
2023
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19. Supplemental Table 1 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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20. Supplemental Figure 1 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma

Author

Gupta, Sumati, primary, Albertson, Daniel J., primary, Parnell, Timothy J., primary, Butterfield, Andrew, primary, Weston, Alexis, primary, Pappas, Lisa M., primary, Dalley, Brian, primary, O’Shea, John M., primary, Lowrance, William T., primary, Cairns, Bradley R., primary, Schiffman, Joshua D., primary, and Sharma, Sunil, primary

Published
2023
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21. Supplementary Methods from Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia

Author

Delker, Don A., primary, Wood, Austin C., primary, Snow, Angela K., primary, Samadder, N. Jewel, primary, Samowitz, Wade S., primary, Affolter, Kajsa E., primary, Boucher, Kenneth M., primary, Pappas, Lisa M., primary, Stijleman, Inge J., primary, Kanth, Priyanka, primary, Byrne, Kathryn R., primary, Burt, Randall W., primary, Bernard, Philip S., primary, and Neklason, Deborah W., primary

Published
2023
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27. Riding the Technology Wave: Effective Dashboard Data Visualization

Author

Pappas, Lisa, Whitman, Lisa, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Smith, Michael J., editor, and Salvendy, Gavriel, editor

Published
2011
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38. Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial

Author

Samadder, N. Jewel, Neklason, Deborah W., Boucher, Kenneth M., Byrne, Kathryn R., Kanth, Priyanka, Samowitz, Wade, Jones, David, Tavtigian, Sean V., Done, Michelle W., Berry, Therese, Jasperson, Kory, Pappas, Lisa, Smith, Laurel, Sample, Danielle, Davis, Rian, Topham, Matthew K., Lynch, Patrick, Strait, Elena, McKinnon, Wendy, Burt, Randall W., and Kuwada, Scott K.

Published
2016
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43. A contradiction in interpretations: a look at the circuit split regarding creditor derivative standing in bankruptcy.

Author

Pappas, Lisa J.

Subjects
Bankruptcy reorganizations -- Laws, regulations and rules, Standing (Law) -- Laws, regulations and rules, Stockholders' derivative actions -- Laws, regulations and rules, Hartford Underwriters Insurance Co. v. Union Planters Bank (530 U.S. 1 (2000)), Unsecured Creditors of Cybergenics Corp. v. Chinery (330 F.3d 548 (3d Cir. 2003)), Company bankruptcy, Government regulation
Published
2010

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