742 results on '"Papiol, Sergi"'
Search Results
2. Cell type-specific polygenic burden modulates exercise effects in schizophrenia patients: further evidence on volumes of hippocampal subfields
- Author
-
Papiol, Sergi, Roell, Lukas, Maurus, Isabel, Hirjak, Dusan, Keeser, Daniel, Schmitt, Andrea, Meyer-Lindenberg, Andreas, and Falkai, Peter
- Published
- 2024
- Full Text
- View/download PDF
3. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.
- Author
-
Amare, Azmeraw, Thalamuthu, Anbupalam, Schubert, Klaus, Fullerton, Janice, Ahmed, Muktar, Hartmann, Simon, Papiol, Sergi, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hou, Liping, Hsu, Yi-Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Hasler, Roland, Richard-Lepouriel, Hélène, Perroud, Nader, Backlund, Lena, Bhattacharjee, Abesh, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna, Birner, Armin, Marie-Claire, Cynthia, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr, Dalkner, Nina, Del Zompo, Maria, DePaulo, J, Étain, Bruno, Jamain, Stephane, Falkai, Peter, Forstner, Andreas, Frisen, Louise, Frye, Mark, Gard, Sébastien, Garnham, Julie, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Fallgatter, Andreas, Stegmaier, Sophia, Ethofer, Thomas, Biere, Silvia, Petrova, Kristiyana, Schuster, Ceylan, Adorjan, Kristina, Budde, Monika, Heilbronner, Maria, Kalman, Janos, Kohshour, Mojtaba, Reich-Erkelenz, Daniela, Schaupp, Sabrina, Schulte, Eva, Senner, Fanny, Vogl, Thomas, Anghelescu, Ion-George, Arolt, Volker, Dannlowski, Udo, Dietrich, Detlef, Figge, Christian, Jäger, Markus, Lang, Fabian, Juckel, Georg, Konrad, Carsten, Reimer, Jens, Schmauß, Max, Schmitt, Andrea, Spitzer, Carsten, von Hagen, Martin, Wiltfang, Jens, Zimmermann, Jörg, Andlauer, Till, Fischer, Andre, Bermpohl, Felix, Ritter, Philipp, Matura, Silke, Gryaznova, Anna, Falkenberg, Irina, Yildiz, Cüneyt, Kircher, Tilo, Schmidt, Julia, Koch, Marius, Gade, Kathrin, Trost, Sarah, Haussleiter, Ida, Lambert, Martin, Rohenkohl, Anja, Kraft, Vivien, Grof, Paul, and Hashimoto, Ryota
- Subjects
Bipolar Disorder ,Humans ,Female ,Male ,Multifactorial Inheritance ,Adult ,Middle Aged ,Lithium ,Treatment Outcome ,Bayes Theorem ,Genome-Wide Association Study ,Glutamic Acid ,Cohort Studies ,Lithium Compounds ,Acetylcholine ,Polymorphism ,Single Nucleotide ,Antimanic Agents - Abstract
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithiums possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P
- Published
- 2023
4. Distinct genetic liability profiles define clinically relevant patient strata across common diseases
- Author
-
Trastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura T., Andlauer, Till F. M., von Scheidt, Moritz, Budde, Monika, Heilbronner, Urs, Papiol, Sergi, Teumer, Alexander, Homuth, Georg, Völzke, Henry, Dörr, Marcus, Falkai, Peter, Schulze, Thomas G., Gagneur, Julien, Iorio, Francesco, Müller-Myhsok, Bertram, Schunkert, Heribert, and Ziller, Michael J.
- Published
- 2024
- Full Text
- View/download PDF
5. Exploring the genetics of lithium response in bipolar disorders
- Author
-
Herrera-Rivero, Marisol, Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Amare, Azmeraw T., Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Biernacka, Joanna M., Birner, Armin, Cearns, Micah, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Colom, Francesc, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J. Raymond, Etain, Bruno, Falkai, Peter, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J., Frank, Josef, Frisén, Louise, Frye, Mark A., Fullerton, Janice M., Gallo, Carla, Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hasler, Roland, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hou, Liping, Hsu, Yi-Hsiang, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Kuo, Po-Hsiu, Kusumi, Ichiro, König, Barbara, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Maj, Mario, Manchia, Mirko, Marie-Claire, Cynthia, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan L., Millischer, Vincent, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Novák, Tomas, Nöthen, Markus M., O’Donovan, Claire, Ozaki, Norio, Papiol, Sergi, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Reif, Andreas, Reininghaus, Eva, Richard-Lepouriel, Hélène, Roberts, Gloria, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schubert, Klaus Oliver, Schulte, Eva C., Schweizer, Barbara W., Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Streit, Fabian, Tekola-Ayele, Fasil, Thalamuthu, Anbupalam, Tortorella, Alfonso, Turecki, Gustavo, Veeh, Julia, Vieta, Eduard, Viswanath, Biju, Witt, Stephanie H., Zandi, Peter P., Alda, Martin, Bauer, Michael, McMahon, Francis J., Mitchell, Philip B., Rietschel, Marcella, Schulze, Thomas G., and Baune, Bernhard T.
- Published
- 2024
- Full Text
- View/download PDF
6. Multimodal workflows optimally predict response to repetitive transcranial magnetic stimulation in patients with schizophrenia: a multisite machine learning analysis
- Author
-
Dong, Mark Sen, Rokicki, Jaroslav, Dwyer, Dominic, Papiol, Sergi, Streit, Fabian, Rietschel, Marcella, Wobrock, Thomas, Müller-Myhsok, Bertram, Falkai, Peter, Westlye, Lars Tjelta, Andreassen, Ole A., Palaniyappan, Lena, Schneider-Axmann, Thomas, Hasan, Alkomiet, Schwarz, Emanuel, and Koutsouleris, Nikolaos
- Published
- 2024
- Full Text
- View/download PDF
7. Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
- Author
-
Ou, Anna H., Rosenthal, Sara B., Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Alda, Martin, Amare, Azmeraw T., Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bauer, Michael, Baune, Bernhard T., Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Biernacka, Joanna M., Cervantes, Pablo, Chen, Guo-Bo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Colom, Francesc, Cousins, David A., Cruceanu, Cristiana, Czerski, Piotr M., Dantas, Clarissa R., Dayer, Alexandre, Del Zompo, Maria, Degenhardt, Franziska, DePaulo, J. Raymond, Étain, Bruno, Falkai, Peter, Fellendorf, Frederike Tabea, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J., Frisén, Louise, Frye, Mark A., Fullerton, Janice M., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Gruber, Oliver, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hofmann, Andrea, Hou, Liping, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kittel-Schneider, Sarah, König, Barbara, Kuo, Po-Hsiu, Kusumi, Ichiro, Lackner, Nina, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Jaramillo, Carlos A. López, MacQueen, Glenda, Maj, Mario, Manchia, Mirko, Marie-Claire, Cynthia, Martinsson, Lina, Mattheisen, Manuel, McCarthy, Michael J., McElroy, Susan L., McMahon, Francis J., Mitchell, Philip B., Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, Ösby, Urban, Ozaki, Norio, Papiol, Sergi, Perlis, Roy H., Pisanu, Claudia, Potash, James B., Pfennig, Andrea, Reich-Erkelenz, Daniela, Reif, Andreas, Reininghaus, Eva Z., Rietschel, Marcella, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schubert, K. Oliver, Schulze, Thomas G., Schweizer, Barbara W., Seemüller, Florian, Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D., Shimoda, Kazutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tighe, Sarah K., Tortorella, Alfonso, Turecki, Gustavo, Vieta, Eduard, Volkert, Julia, Witt, Stephanie, Wray, Naomi R., Wright, Adam, Young, L. Trevor, Zandi, Peter P., and Kelsoe, John R.
- Published
- 2024
- Full Text
- View/download PDF
8. Neurobiology of Schizophrenia
- Author
-
Schmitt, Andrea, Popovic, David, Raabe, Florian, Papiol, Sergi, Martins-de-Souza, Daniel, Falkai, Peter, Schulze, Thomas G., Section editor, Laje, Gonzalo, Section editor, Tasman, Allan, editor, Riba, Michelle B., editor, Alarcón, Renato D., editor, Alfonso, César A., editor, Kanba, Shigenobu, editor, Lecic-Tosevski, Dusica, editor, Ndetei, David M., editor, Ng, Chee H., editor, and Schulze, Thomas G., editor
- Published
- 2024
- Full Text
- View/download PDF
9. Schizophrenia polygenic risk score in psychosis proneness
- Author
-
Mas-Bermejo, Patricia, Papiol, Sergi, Via, Marc, Rovira, Paula, Torrecilla, Pilar, Kwapil, Thomas R., Barrantes-Vidal, Neus, and Rosa, Araceli
- Published
- 2023
- Full Text
- View/download PDF
10. Signature of Altered Retinal Microstructures and Electrophysiology in Schizophrenia Spectrum Disorders Is Associated With Disease Severity and Polygenic Risk
- Author
-
de Almeida, Valéria, Behrens, Stephanie, Boudriot, Emanuel, Campana, Mattia, Dengl, Fanny, Falkai, Peter, Fischer, Laura E., Gabellini, Nadja, Gabriel, Vanessa, Geyer, Thomas, Hanken, Katharina, Hasan, Alkomiet, Hasanaj, Genc, Ioannou, Georgios, Jäger, Iris, de Jonge, Sylvia, Karali, Temmuz, Karch, Susanne, Karslı, Berkhan, Keeser, Daniel, Kern, Christoph, Klimas, Nicole, Krčmář, Lenka, Melcher, Julian, Mortazavi, Matin, Moussiopoulou, Joanna, Neumeier, Karin, Padberg, Frank, Papazov, Boris, Papiol, Sergi, Pingen, Pauline, Pogarell, Oliver, Priglinger, Siegfried, Raabe, Florian J., Roell, Lukas, Rossner, Moritz J., Schmitt, Andrea, Schmölz, Susanne, Schulz, Enrico, Schworm, Benedikt, Wagner, Elias, Wichert, Sven, Yakimov, Vladislav, Zill, Peter, Popovic, David, Xu, Simiao, and Schulte, Eva C.
- Published
- 2024
- Full Text
- View/download PDF
11. Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study
- Author
-
Moreno-Gamazo, Nerea, Pries, Lotta-Katrin, Marqués-Feixa, Laia, Papiol, Sergi, Romero, Soledad, Menne-Lothmann, Claudia, Decoster, Jeroen, van Winkel, Ruud, Collip, Dina, Delespaul, Philippe, De Hert, Marc, Derom, Catherine, Thiery, Evert, Jacobs, Nele, Wichers, Marieke, van Os, Jim, Rutten, Bart P.F., Fañanás, Lourdes, and Guloksuz, Sinan
- Published
- 2025
- Full Text
- View/download PDF
12. Sex-specific association between schizophrenia polygenic risk and subclinical schizophrenia-related traits
- Author
-
Mas-Bermejo, Patricia, Papiol, Sergi, Torrecilla, Pilar, Lavín, Valeria, Kwapil, Thomas R., Barrantes-Vidal, Neus, and Rosa, Araceli
- Published
- 2025
- Full Text
- View/download PDF
13. The microRNA profile of brain-derived extracellular vesicles: A promising step forward in developing pharmacodynamic biomarkers for psychiatric disorders
- Author
-
Oraki Kohshour, Mojtaba, Heilbronner, Urs, Mueller, Thorsten, Rossner, Moritz, Papiol, Sergi, and Schulze, Thomas G.
- Published
- 2025
- Full Text
- View/download PDF
14. Extracellular vesicle approach to major psychiatric disorders
- Author
-
Oraki Kohshour, Mojtaba, Papiol, Sergi, Delalle, Ivana, Rossner, Moritz J., and Schulze, Thomas G.
- Published
- 2023
- Full Text
- View/download PDF
15. Lithium response in bipolar disorder: Epigenome-wide DNA methylation signatures and epigenetic aging
- Author
-
Zafrilla-López, Marina, Acosta-Díez, Miriam, Mitjans, Marina, Giménez-Palomo, Anna, Saiz, Pilar A, Barrot-Feixat, Carme, Jiménez, Ester, Papiol, Sergi, Ruiz, Victoria, Gavín, Patrícia, García-Portilla, María Paz, González-Blanco, Leticia, Bobes, Julio, Schulze, Thomas G, Vieta, Eduard, Benabarre, Antoni, and Arias, Bárbara
- Published
- 2024
- Full Text
- View/download PDF
16. Correction: Common genetic variants contribute to heritability of age at onset of schizophrenia
- Author
-
Sada-Fuente, Ester, Aranda, Selena, Papiol, Sergi, Heilbronner, Urs, Moltó, María Dolores, Aguilar, Eduardo J., González-Peñas, Javier, Andreu-Bernabeu, Álvaro, Arango, Celso, Crespo-Facorro, Benedicto, González-Pinto, Ana, Fañanás, Lourdes, Arias, Barbara, Bobes, Julio, Costas, Javier, Martorell, Lourdes, Schulze, Thomas G., Kalman, Janos L., Vilella, Elisabet, and Muntané, Gerard
- Published
- 2023
- Full Text
- View/download PDF
17. Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia
- Author
-
Guardiola-Ripoll, Maria, Almodóvar-Payá, Carmen, Arias-Magnasco, Angelo, Latorre-Guardia, Mariona, Papiol, Sergi, Canales-Rodríguez, Erick J., García-León, María Ángeles, Fuentes-Claramonte, Paola, Salavert, Josep, Tristany, Josep, Torres, Llanos, Rodríguez-Cano, Elena, Salvador, Raymond, Pomarol-Clotet, Edith, and Fatjó-Vilas, Mar
- Published
- 2023
- Full Text
- View/download PDF
18. Common genetic variants contribute to heritability of age at onset of schizophrenia
- Author
-
Sada-Fuente, Ester, Aranda, Selena, Papiol, Sergi, Heilbronner, Urs, Moltó, María Dolores, Aguilar, Eduardo J., González-Peñas, Javier, Andreu-Bernabeu, Álvaro, Arango, Celso, Crespo-Facorro, Benedicto, González-Pinto, Ana, Fañanás, Lourdes, Arias, Barbara, Bobes, Julio, Costas, Javier, Martorell, Lourdes, Schulze, Thomas G., Kalman, Janos L., Vilella, Elisabet, and Muntané, Gerard
- Published
- 2023
- Full Text
- View/download PDF
19. Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study
- Author
-
Senner, Fanny, Hiendl, Lena, Bengesser, Susanne, Adorjan, Kristina, Anghelescu, Ion-George, Baune, Bernhardt T., Budde, Monika, Dannlowski, Udo, Dietrich, Detlef E., Falkai, Peter, Fallgatter, Andreas J., Hasan, Alkomiet, Heilbronner, Maria, Jäger, Markus, Juckel, Georg, Kalman, Janos L., Konrad, Carsten, Kohshour, Mojtaba Oraki, Papiol, Sergi, Reich-Erkelenz, Daniela, Reimer, Jens, Schaupp, Sabrina K., Schmauß, Max, Senner, Simon, Spitzer, Carsten, Vogl, Thomas, Zimmermann, Jörg, Heilbronner, Urs, Schulte, Eva C., Schulze, Thomas G., Reininghaus, Eva Z., Kirchner, Sophie-Kathrin, and Dalkner, Nina
- Published
- 2023
- Full Text
- View/download PDF
20. Characterisation of age and polarity at onset in bipolar disorder.
- Author
-
Kalman, Janos L, Olde Loohuis, Loes M, Vreeker, Annabel, McQuillin, Andrew, Stahl, Eli A, Ruderfer, Douglas, Grigoroiu-Serbanescu, Maria, Panagiotaropoulou, Georgia, Ripke, Stephan, Bigdeli, Tim B, Stein, Frederike, Meller, Tina, Meinert, Susanne, Pelin, Helena, Streit, Fabian, Papiol, Sergi, Adams, Mark J, Adolfsson, Rolf, Adorjan, Kristina, Agartz, Ingrid, Aminoff, Sofie R, Anderson-Schmidt, Heike, Andreassen, Ole A, Ardau, Raffaella, Aubry, Jean-Michel, Balaban, Ceylan, Bass, Nicholas, Baune, Bernhard T, Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Berrettini, Wade H, Boks, Marco P, Bromet, Evelyn J, Brosch, Katharina, Budde, Monika, Byerley, William, Cervantes, Pablo, Chillotti, Catina, Cichon, Sven, Clark, Scott R, Comes, Ashley L, Corvin, Aiden, Coryell, William, Craddock, Nick, Craig, David W, Croarkin, Paul E, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Dannlowski, Udo, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J Raymond, Djurovic, Srdjan, Edenberg, Howard J, Eissa, Mariam Al, Elvsåshagen, Torbjørn, Etain, Bruno, Fanous, Ayman H, Fellendorf, Frederike, Fiorentino, Alessia, Forstner, Andreas J, Frye, Mark A, Fullerton, Janice M, Gade, Katrin, Garnham, Julie, Gershon, Elliot, Gill, Michael, Goes, Fernando S, Gordon-Smith, Katherine, Grof, Paul, Guzman-Parra, Jose, Hahn, Tim, Hasler, Roland, Heilbronner, Maria, Heilbronner, Urs, Jamain, Stephane, Jimenez, Esther, Jones, Ian, Jones, Lisa, Jonsson, Lina, Kahn, Rene S, Kelsoe, John R, Kennedy, James L, Kircher, Tilo, Kirov, George, Kittel-Schneider, Sarah, Klöhn-Saghatolislam, Farah, Knowles, James A, Kranz, Thorsten M, Lagerberg, Trine Vik, Landen, Mikael, Lawson, William B, Leboyer, Marion, Li, Qingqin S, Maj, Mario, Malaspina, Dolores, Manchia, Mirko, and Mayoral, Fermin
- Subjects
Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group ,International Consortium on Lithium Genetics ,Colombia-US Cross Disorder Collaboration in Psychiatric Genetics ,Humans ,Bipolar Disorder ,Depressive Disorder ,Major ,Age of Onset ,Multifactorial Inheritance ,Genome-Wide Association Study ,Autism Spectrum Disorder ,Bipolar disorder ,GWAS ,age at onset ,polarity at onset ,polygenic score ,Genetics ,Mental Health ,Prevention ,Brain Disorders ,Serious Mental Illness ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Good Health and Well Being ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
BackgroundStudying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = -0.34 years, s.e. = 0.08), major depression (β = -0.34 years, s.e. = 0.08), schizophrenia (β = -0.39 years, s.e. = 0.08), and educational attainment (β = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
- Published
- 2021
21. Long-term trajectories of clinical staging in first-episode psychosis and their associated cognitive outcome: A 21-year follow-up study
- Author
-
Ballesteros, Alejandro, Fañanás, Lourdes, Janda, Lucia, Papiol, Sergi, Peralta, David, Ribeiro, María, Rosero, Ángela, Zarzuela, Amalia, Giné, Eloi, Rosado, Esther, Cuesta, Manuel J., Sánchez-Torres, Ana M., Moreno-Izco, Lucia, García de Jalón, Elena, Gil-Berrozpe, Gustavo J., and Peralta, Victor
- Published
- 2024
- Full Text
- View/download PDF
22. Association of clinical parameters and polygenic risk scores for body mass index, schizophrenia, and diabetes with antipsychotic-induced weight gain
- Author
-
Franz, Maria, Papiol, Sergi, Simon, Maria S., Barton, Barbara B., Glockner, Catherine, Spellmann, Ilja, Riedel, Michael, Heilbronner, Urs, Zill, Peter, Schulze, Thomas G., and Musil, Richard
- Published
- 2024
- Full Text
- View/download PDF
23. Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
- Author
-
Schmitt, Andrea, Falkai, Peter, and Papiol, Sergi
- Published
- 2023
- Full Text
- View/download PDF
24. Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study
- Author
-
Coombes, Brandon J, Millischer, Vincent, Batzler, Anthony, Larrabee, Beth, Hou, Liping, Papiol, Sergi, Heilbronner, Urs, Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Amare, Azmeraw T, Ardau, Raffaella, Arias, Barbara, Aubry, Jean-Michel, Backlund, Lena, Bauer, Michael, Baune, Bernhard T, Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R, Colom, Francesc, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J Raymond, Étain, Bruno, Falkai, Peter, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J, Frisen, Louise, Gard, Sébastien, Garnham, Julie S, Goes, Fernando S, Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kelsoe, John R, Kittel-Schneider, Sarah, König, Barbara, Kuo, Po-Hsiu, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G, Maj, Mario, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J, McElroy, Susan L, Mitchell, Philip B, Mitjans, Marina, Mondimore, Francis M, Monteleone, Palmiero, Nievergelt, Caroline M, Nöthen, Markus M, Novák, Tomas, O'Donovan, Claire, Osby, Urban, Ozaki, Norio, Pfennig, Andrea, Pisanu, Claudia, Potash, James B, Reif, Andreas, Reininghaus, Eva, Rietschel, Marcella, Rouleau, Guy A, Rybakowski, Janusz K, Schalling, Martin, Schofield, Peter R, Schubert, Klaus Oliver, Schweizer, Barbara W, Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D, Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M, Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tortorella, Alfonso, and Turecki, Gustavo
- Subjects
Brain Disorders ,Serious Mental Illness ,Prevention ,Attention Deficit Hyperactivity Disorder (ADHD) ,Schizophrenia ,Depression ,Mental Health ,Bipolar Disorder ,Behavioral and Social Science ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Good Health and Well Being ,Adherence ,Attention-deficit/hyperactivity disorder ,Bipolar disorder ,Lithium response ,Polygenic risk scores - Abstract
Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
- Published
- 2021
25. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
- Author
-
Schubert, Klaus Oliver, Thalamuthu, Anbupalam, Amare, Azmeraw T, Frank, Joseph, Streit, Fabian, Adl, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M, Birner, Armin, Marie-Claire, Cynthia, Cearns, Micah, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Dayer, Alexandre, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J Raymond, Étain, Bruno, Falkai, Peter, Forstner, Andreas J, Frisen, Louise, Frye, Mark A, Fullerton, Janice M, Gard, Sébastien, Garnham, Julie S, Goes, Fernando S, Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hou, Liping, Hsu, Yi-Hsiang, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Ferensztajn-Rochowiak, Ewa, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G, Maj, Mario, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J, McElroy, Susan, Colom, Francesc, Mitjans, Marina, Mondimore, Francis M, Monteleone, Palmiero, Nievergelt, Caroline M, Nöthen, Markus M, Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Ösby, Urban, Papiol, Sergi, Pfennig, Andrea, Pisanu, Claudia, Potash, James B, Reif, Andreas, Reininghaus, Eva, Rouleau, Guy A, Rybakowski, Janusz K, Schalling, Martin, Schofield, Peter R, Schweizer, Barbara W, Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D, Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M, Squassina, Alessio, and Stamm, Thomas
- Subjects
Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Serious Mental Illness ,Mental Health ,Brain Disorders ,Schizophrenia ,Bipolar Disorder ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Good Health and Well Being ,Depression ,Depressive Disorder ,Major ,Genetic Predisposition to Disease ,Humans ,Lithium ,Multifactorial Inheritance ,Risk Factors ,Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium ,Clinical Sciences ,Public Health and Health Services ,Clinical sciences ,Neurosciences ,Biological psychology - Abstract
Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well understood, and personalized treatment in BD remains elusive. Genetic analyses of the lithium treatment response phenotype may generate novel molecular insights into lithium's therapeutic mechanisms and lead to testable hypotheses to improve BD management and outcomes. We used fixed effect meta-analysis techniques to develop meta-analytic polygenic risk scores (MET-PRS) from combinations of highly correlated psychiatric traits, namely schizophrenia (SCZ), major depression (MD) and bipolar disorder (BD). We compared the effects of cross-disorder MET-PRS and single genetic trait PRS on lithium response. For the PRS analyses, we included clinical data on lithium treatment response and genetic information for n = 2283 BD cases from the International Consortium on Lithium Genetics (ConLi+Gen; www.ConLiGen.org ). Higher SCZ and MD PRSs were associated with poorer lithium treatment response whereas BD-PRS had no association with treatment outcome. The combined MET2-PRS comprising of SCZ and MD variants (MET2-PRS) and a model using SCZ and MD-PRS sequentially improved response prediction, compared to single-disorder PRS or to a combined score using all three traits (MET3-PRS). Patients in the highest decile for MET2-PRS loading had 2.5 times higher odds of being classified as poor responders than patients with the lowest decile MET2-PRS scores. An exploratory functional pathway analysis of top MET2-PRS variants was conducted. Findings may inform the development of future testing strategies for personalized lithium prescribing in BD.
- Published
- 2021
26. Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses
- Author
-
Kalman, Janos L., Yoshida, Tomoya, Andlauer, Till F. M., Schulte, Eva C., Adorjan, Kristina, Alda, Martin, Ardau, Raffaela, Aubry, Jean-Michel, Brosch, Katharina, Budde, Monika, Chillotti, Caterina, Czerski, Piotr M., DePaulo, Raymond J., Forstner, Andreas, Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Grotegerd, Dominik, Hahn, Tim, Heilbronner, Maria, Hasler, Roland, Heilbronner, Urs, Heilmann-Heimbach, Stefanie, Kapelski, Pawel, Kato, Tadafumi, Kohshour, Mojtaba Oraki, Meinert, Susanne, Meller, Tina, Nenadić, Igor, Nöthen, Markus M., Novak, Tomas, Opel, Nils, Pawlak, Joanna, Pfarr, Julia-Katharina, Potash, James B., Reich-Erkelenz, Daniela, Repple, Jonathan, Richard-Lepouriel, Hélène, Rietschel, Marcella, Ringwald, Kai G., Rouleau, Guy, Schaupp, Sabrina, Senner, Fanny, Severino, Giovanni, Squassina, Alessio, Stein, Frederike, Stopkova, Pavla, Streit, Fabian, Thiel, Katharina, Thomas-Odenthal, Florian, Turecki, Gustavo, Twarowska-Hauser, Joanna, Winter, Alexandra, Zandi, Peter P., Kelsoe, John R., Falkai, Peter, Dannlowski, Udo, Kircher, Tilo, Schulze, Thomas G., and Papiol, Sergi
- Published
- 2022
- Full Text
- View/download PDF
27. Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis
- Author
-
Pistis, Giorgio, Vázquez-Bourgon, Javier, Fournier, Margot, Jenni, Raoul, Cleusix, Martine, Papiol, Sergi, Smart, Sophie E., Pardiñas, Antonio F., Walters, James T. R., MacCabe, James H., Kutalik, Zoltán, Conus, Philippe, Crespo-Facorro, Benedicto, and Q Do, Kim
- Published
- 2022
- Full Text
- View/download PDF
28. Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls
- Author
-
Senner, Fanny, Schneider-Axmann, Thomas, Kaurani, Lalit, Zimmermann, Jörg, Wiltfang, Jens, von Hagen, Martin, Vogl, Thomas, Spitzer, Carsten, Senner, Simon, Schulte, Eva C., Schmauß, Max, Schaupp, Sabrina K., Reimer, Jens, Reich-Erkelenz, Daniela, Papiol, Sergi, Kohshour, Mojtaba Oraki, Lang, Fabian U., Konrad, Carsten, Kirchner, Sophie-Kathrin, Kalman, Janos L., Juckel, Georg, Heilbronner, Maria, Heilbronner, Urs, Figge, Christian, Eyl, Ruth E., Dietrich, Detlef, Budde, Monika, Angelescu, Ion-George, Adorjan, Kristina, Schmitt, Andrea, Fischer, Andre, Falkai, Peter, and Schulze, Thomas G.
- Published
- 2023
- Full Text
- View/download PDF
29. Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review
- Author
-
Murillo-Garcia, Nancy, Barrio-Martrnez, Sara, Setien-Suero, Esther, Soler, Jordi, Papiol, Sergi, Fatjo-Vilas, Mar, and Ayesa-Arriola, Rosa
- Subjects
Intellect -- Genetic aspects ,Intelligence levels -- Genetic aspects ,Schizophrenia -- Genetic aspects ,Genetic variation -- Health aspects -- Psychological aspects ,Health ,Psychology and mental health - Abstract
Background: To study whether there is genetic overlap underlying the risk for schizophrenia spectrum disorders (SSDs) and low intelligence quotient (IQ), we reviewed and summarized the evidence on genetic variants associated with both traits. Methods: We performed this review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and preregistered it in PROSPERO. We searched the Medline databases via PubMed, PsycInfo, Web of Science and Scopus. We included studies in adults with a diagnosis of SSD that explored genetic variants (single nucleotide polymorphisms [SNPs], copy number variants [CNVs], genomic insertions or genomic deletions), estimated IQ and studied the relationship between genetic variability and both traits (SSD and IQ). We synthesized the results and assessed risk of bias using the Quality of Genetic Association Studies (Q-Genie) tool. Results: Fifty-five studies met the inclusion criteria (45 case-control, 9 cross-sectional, 1 cohort), of which 55% reported significant associations for genetic variants involved in IQ and SSD. The SNPs more frequently explored through candidate gene studies were in COMT, DTNBP1, BDNF and TCF4. Through genome-wide association studies, 2 SNPs in CHD7 and GATAD2A were associated with IQ in patients with SSD. The studies on CNVs suggested significant associations between structural variants and low IQ in patients with SSD. Limitations: Overall, primary studies used heterogeneous IQ measurement tools and had small samples. Grey literature was not screened. Conclusion: Genetic overlap between SSD and IQ supports the neurodevelopmental hypothesis of schizophrenia. Most of the risk polymorphisms identified were in genes relevant to brain development, neural proliferation and differentiation, and synaptic plasticity., Introduction Schizophrenia spectrum disorders (SSDs) are characterized by hallucinations, delusions, disorganized thinking, negative symptoms and cognitive dysfunctions that compromise functionality. (1,2) They differ from each other according to type of [...]
- Published
- 2022
30. Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
- Author
-
Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Jr., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C.K., Chan, Ronald Y.L., Chen, Eric Y.H., Cheng, Wei, Cheung, Eric FC., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Lee, Jimmy, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K.E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Spencer, Chris C.A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H.M., Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H.R., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sham, Pak C., Sklar, Pamela, St Clair, David, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Sullivan, Patrick F., O'Donovan, Michael C., Qin, Shengying, Sawa, Akira, Kahn, Rene, Hong, Kyung Sue, Shi, Wenzhao, Tsuang, Ming, Itokawa, Masanari, Feng, Gang, Glatt, Stephen J., Ma, Xiancang, Tang, Jinsong, Ruan, Yunfeng, Liu, Ruize, Zhu, Feng, Horiuchi, Yasue, Lee, Byung Dae, Joo, Eun-Jeong, Myung, Woojae, Ha, Kyooseob, Won, Hong-Hee, Baek, Ji Hyung, Chung, Young Chul, Kim, Sung-Wan, Kusumawardhani, Agung, Chen, Wei J., Hwu, Hai-Gwo, Hishimoto, Akitoyo, Otsuka, Ikuo, Sora, Ichiro, Toyota, Tomoko, Yoshikawa, Takeo, Kunugi, Hiroshi, Hattori, Kotaro, Ishiwata, Sayuri, Numata, Shusuke, Ohmori, Tetsuro, Arai, Makoto, Ozeki, Yuji, Fujii, Kumiko, Kim, Se Joo, Lee, Heon-Jeong, Ahn, Yong Min, Kim, Se Hyun, Akiyama, Kazufumi, Shimoda, Kazutaka, Kinoshita, Makoto, Hsu, Yu-Han H., Pintacuda, Greta, Nacu, Eugeniu, Kim, April, Tsafou, Kalliopi, Petrossian, Natalie, Crotty, William, Suh, Jung Min, Riseman, Jackson, Martin, Jacqueline M., Biagini, Julia C., Mena, Daya, Ching, Joshua K.T., Malolepsza, Edyta, Li, Taibo, Singh, Tarjinder, Ge, Tian, Egri, Shawn B., Tanenbaum, Benjamin, Stanclift, Caroline R., Apffel, Annie M., Carr, Steven A., Schenone, Monica, Jaffe, Jake, Fornelos, Nadine, Eggan, Kevin C., and Lage, Kasper
- Published
- 2023
- Full Text
- View/download PDF
31. Association between mitochondria-related genes and cognitive performance in the PsyCourse Study
- Author
-
Oraki Kohshour, Mojtaba, Schulte, Eva C., Heilbronner, Urs, Budde, Monika, Kalman, Janos L., Senner, Fanny, Heilbronner, Maria, Reich-Erkelenz, Daniela, Schaupp, Sabrina K., Vogl, Thomas, Adorjan, Kristina, Anghelescu, Ion-George, Arolt, Volker, Baune, Bernhardt T., Dannlowski, Udo, Dietrich, Detlef, Fallgatter, Andreas, Figge, Christian, Jäger, Markus, Lang, Fabian U., Juckel, Georg, Konrad, Carsten, Reimer, Jens, Reininghaus, Eva Z., Schmauß, Max, Spitzer, Carsten, von Hagen, Martin, Wiltfang, Jens, Zimmermann, Jörg, Andlauer, Till F.M., Nöthen, Markus M., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Witt, Stephanie H., Fischer, Andre, Falkai, Peter, Papiol, Sergi, and Schulze, Thomas G.
- Published
- 2023
- Full Text
- View/download PDF
32. A functional neuroimaging association study on the interplay between two schizophrenia genome-wide associated genes (CACNA1C and ZNF804A)
- Author
-
Guardiola-Ripoll, Maria, Almodóvar-Payá, Carmen, Lubeiro, Alba, Sotero, Alejandro, Salvador, Raymond, Fuentes-Claramonte, Paola, Salgado-Pineda, Pilar, Papiol, Sergi, Ortiz-Gil, Jordi, Gomar, Jesús J., Guerrero-Pedraza, Amalia, Sarró, Salvador, Maristany, Teresa, Molina, Vicente, Pomarol-Clotet, Edith, and Fatjó-Vilas, Mar
- Published
- 2022
- Full Text
- View/download PDF
33. Neurobiology of Schizophrenia
- Author
-
Schmitt, Andrea, primary, Popovic, David, additional, Raabe, Florian, additional, Papiol, Sergi, additional, Martins-de-Souza, Daniel, additional, and Falkai, Peter, additional
- Published
- 2023
- Full Text
- View/download PDF
34. Genetic contributions to transdiagnostic symptom dimensions in patients with major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders
- Author
-
David, Friederike S., Stein, Frederike, Andlauer, Till F.M., Streit, Fabian, Witt, Stephanie H., Herms, Stefan, Hoffmann, Per, Heilmann-Heimbach, Stefanie, Opel, Nils, Repple, Jonathan, Jansen, Andreas, Nenadić, Igor, Papiol, Sergi, Heilbronner, Urs, Kalman, Janos L., Schaupp, Sabrina K., Senner, Fanny, Schulte, Eva C., Falkai, Peter G., Schulze, Thomas G., Dannlowski, Udo, Kircher, Tilo, Rietschel, Marcella, Nöthen, Markus M., Krug, Axel, and Forstner, Andreas J.
- Published
- 2023
- Full Text
- View/download PDF
35. New insights of the role of the KCNH2 gene in schizophrenia: An fMRI case-control study
- Author
-
Guardiola-Ripoll, Maria, Almodóvar-Payá, Carmen, Lubeiro, Alba, Salvador, Raymond, Salgado-Pineda, Pilar, Gomar, Jesús J, Guerrero-Pedraza, Amalia, Sarró, Salvador, Maristany, Teresa, Fernández-Linsenbarth, Inés, Hernández-García, Marta, Papiol, Sergi, Molina, Vicente, Pomarol-Clotet, Edith, and Fatjó-Vilas, Mar
- Published
- 2022
- Full Text
- View/download PDF
36. Peripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-naïve schizophrenia
- Author
-
Lago, Santiago G., Tomasik, Jakub, van Rees, Geertje F., Rustogi, Nitin, Vázquez-Bourgon, Javier, Papiol, Sergi, Suarez-Pinilla, Paula, Crespo-Facorro, Benedicto, and Bahn, Sabine
- Published
- 2022
- Full Text
- View/download PDF
37. A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study
- Author
-
Schulte, Eva C., Kondofersky, Ivan, Budde, Monika, Papiol, Sergi, Senner, Fanny, Schaupp, Sabrina K., Reich-Erkelenz, Daniela, Klöhn-Saghatolislam, Farahnaz, Kalman, Janos L., Gade, Katrin, Hake, Maria, Comes, Ashley L., Anderson-Schmidt, Heike, Adorjan, Kristina, Juckel, Georg, Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Wiltfang, Jens, Reininghaus, Eva Z., Anghelescu, Ion-George, Konrad, Carsten, Figge, Christian, von Hagen, Martin, Jäger, Markus, Dietrich, Detlef E., Spitzer, Carsten, Witt, Stephanie H., Forstner, Andreas J., Rietschel, Marcella, Nöthen, Markus M., Falkai, Peter, Heilbronner, Urs, Mueller, Nikola S., and Schulze, Thomas G.
- Published
- 2022
- Full Text
- View/download PDF
38. Genetic variants associated with longitudinal changes in brain structure across the lifespan
- Author
-
Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S., Olde Loohuis, Loes M., Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Bastin, Mark E., Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E. L., Bülow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, de Mol, Casper L., de Zwarte, Sonja M. C., Desrivières, Sylvane, Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K. M., Harris, Mathew A., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, René C. W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A., Mühleisen, Thomas W., Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J., Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V., Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E. M., Wardlaw, Joanna M., Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H., Zugman, Andre, Armstrong, Nicola J., Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Gonzalez-Peñas, Javier, Guimaraes, Joao P. O. F. T., Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J., Kwok, John B. J., Le Hellard, Stephanie, Mather, Karen A., Milaneschi, Yuri, Morris, Derek W., Nöthen, Markus M., Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L., Steen, Vidar M., Stein, Jason L., Streit, Fabian, Tankard, Rick M., Teumer, Alexander, van ‘t Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H., Adams, Hieab H. H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A., Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L. W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Buitelaar, Jan K., Cahn, Wiepke, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R., Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter G., Fisher, Simon E., Flor, Herta, Fullerton, Janice M., Garavan, Hugh, Gowland, Penny A., Grabe, Hans J., Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J., Ikram, Mohammad A., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Korgaonkar, Mayuresh S., Krug, Axel, Lemaitre, Herve, Malt, Ulrik F., Martinot, Jean-Luc, McDonald, Colm, Mitchell, Philip B., Muetzel, Ryan L., Murray, Robin M., Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A., Pan, Pedro M., Penninx, Brenda W. J. H., Poustka, Luise, Sachdev, Perminder S., Salum, Giovanni A., Schofield, Peter R., Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N., Stein, Dan J., Trollor, Julian N., van den Berg, Leonard H., Veldink, Jan H., Walter, Henrik, Westlye, Lars T., Whelan, Robert, White, Tonya, Wright, Margaret J., Medland, Sarah E., Franke, Barbara, Thompson, Paul M., and Hulshoff Pol, Hilleke E.
- Published
- 2022
- Full Text
- View/download PDF
39. Completed suicide is associated with a higher polygenic burden for psychiatric disorders
- Author
-
Mitjans, Marina, Papiol, Sergi, Barrot, Carme, Guardiola-Ripoll, Maria, Giménez-Palomo, Anna, Gavín, Patricia, Oraki Kohshour, Mojtaba, Acosta, Miriam, Pomarol-Clotet, Edith, Castellà-García, Josep, Pérez-Pérez, Rosa M., Gutiérrez, Blanca, Schulze, Thomas G., Fatjó-Vilas, Mar, Arias, Bárbara, and Benabarre, Antoni
- Published
- 2022
- Full Text
- View/download PDF
40. Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
- Author
-
Schubert, Klaus Oliver, Thalamuthu, Anbupalam, Amare, Azmeraw T., Frank, Joseph, Streit, Fabian, Adl, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Marie-Claire, Cynthia, Cearns, Micah, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Dayer, Alexandre, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Falkai, Peter, Forstner, Andreas J., Frisen, Louise, Frye, Mark A., Fullerton, Janice M., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hou, Liping, Hsu, Yi-Hsiang, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Ferensztajn-Rochowiak, Ewa, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Maj, Mario, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan, Colom, Francesc, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Ösby, Urban, Papiol, Sergi, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Reif, Andreas, Reininghaus, Eva, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schweizer, Barbara W., Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tekola-Ayele, Fasil, Tortorella, Alfonso, Turecki, Gustavo, Veeh, Julia, Vieta, Eduard, Witt, Stephanie H., Roberts, Gloria, Zandi, Peter P., Alda, Martin, Bauer, Michael, McMahon, Francis J., Mitchell, Philip B., Schulze, Thomas G., Rietschel, Marcella, and Baune, Bernhard T.
- Published
- 2022
- Full Text
- View/download PDF
41. Comparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles
- Author
-
Oraki Kohshour, Mojtaba, Kannaiyan, Nirmal R., Falk, August Jernbom, Papiol, Sergi, Heilbronner, Urs, Budde, Monika, Kalman, Janos L., Schulte, Eva C., Rietschel, Marcella, Witt, Stephanie, Forstner, Andreas J., Heilmann-Heimbach, Stefanie, Nöthen, Markus M., Spitzer, Carsten, Malchow, Berend, Müller, Thorsten, Wiltfang, Jens, Falkai, Peter, Schmitt, Andrea, Rossner, Moritz J., Nilsson, Peter, and Schulze, Thomas G.
- Published
- 2022
- Full Text
- View/download PDF
42. Shared vulnerability and sex-dependent polygenic burden in psychotic disorders.
- Author
-
Mitjans, Marina, Papiol, Sergi, Fatjó-Vilas, Mar, González-Peñas, Javier, Acosta-Díez, Miriam, Zafrilla-López, Marina, Costas, Javier, Arango, Celso, Vilella, Elisabet, Martorell, Lourdes, Moltó, M Dolores, Bobes, Julio, Crespo-Facorro, Benedicto, González-Pinto, Ana, Fañanás, Lourdes, Rosa, Araceli, and Arias, Bárbara
- Subjects
- *
PSYCHOSES , *MENTAL depression , *BIPOLAR disorder , *MENTAL illness , *SCHIZOPHRENIA - Abstract
• Polygenic scores for schizophrenia, bipolar disorder and major depressive disorder show association with broadly defined psychosis. • Evidence of the shared genetic architecture across psychotic disorders. • Sex-dependent differences in the genetic vulnerability to psychotic disorders. Evidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sex-dependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
43. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
- Author
-
Consortium, Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics, Ruderfer, Douglas M, Ripke, Stephan, McQuillin, Andrew, Boocock, James, Stahl, Eli A, Pavlides, Jennifer M Whitehead, Mullins, Niamh, Charney, Alexander W, Ori, Anil PS, Loohuis, Loes M Olde, Domenici, Enrico, Di Florio, Arianna, Papiol, Sergi, Kalman, Janos L, Trubetskoy, Vassily, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Akil, Huda, Albani, Diego, Albus, Margot, Alda, Martin, Alexander, Madeline, Alliey-Rodriguez, Ney, Als, Thomas D, Amin, Farooq, Anjorin, Adebayo, Arranz, Maria J, Awasthi, Swapnil, Bacanu, Silviu A, Badner, Judith A, Baekvad-Hansen, Marie, Bakker, Steven, Band, Gavin, Barchas, Jack D, Barroso, Ines, Bass, Nicholas, Bauer, Michael, Baune, Bernhard T, Begemann, Martin, Bellenguez, Celine, Belliveau, Richard A, Bellivier, Frank, Bender, Stephan, Bene, Judit, Bergen, Sarah E, Berrettini, Wade H, Bevilacqua, Elizabeth, Biernacka, Joanna M, Bigdeli, Tim B, Black, Donald W, Blackburn, Hannah, Blackwell, Jenefer M, Blackwood, Douglas HR, Pedersen, Carsten Bocker, Boehnke, Michael, Boks, Marco, Borglum, Anders D, Bramon, Elvira, Breen, Gerome, Brown, Matthew A, Bruggeman, Richard, Buccola, Nancy G, Buckner, Randy L, Budde, Monika, Bulik-Sullivan, Brendan, Bumpstead, Suzannah J, Bunney, William, Burmeister, Margit, Buxbaum, Joseph D, Bybjerg-Grauholm, Jonas, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Cairns, Murray J, Campion, Dominique, Cantor, Rita M, Carr, Vaughan J, Carrera, Noa, Casas, Juan P, Casas, Miquel, Catts, Stanley V, Cervantes, Pablo, Chambert, Kimberley D, Chan, Raymond CK, Chen, Eric YH, Chen, Ronald YL, Cheng, Wei, Cheung, Eric FC, Chong, Siow Ann, Clarke, Toni-Kim, Cloninger, C Robert, Cohen, David, Cohen, Nadine, Coleman, Jonathan RI, Collier, David A, Cormican, Paul, Coryell, William, and Craddock, Nicholas
- Subjects
Human Genome ,Neurosciences ,Serious Mental Illness ,Bipolar Disorder ,Biotechnology ,Schizophrenia ,Brain Disorders ,Genetics ,Mental Health ,Mental health ,Good Health and Well Being ,Case-Control Studies ,Genetic Loci ,Genome-Wide Association Study ,Humans ,Multifactorial Inheritance ,Odds Ratio ,Phenotype ,Risk ,White People ,Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: douglas.ruderfer@vanderbilt.edu ,Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium ,bipolar disorder ,polygenic risk ,psychosis ,schizophrenia ,subphenotypes ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment.
- Published
- 2018
44. Interaction Between Genes and Childhood Trauma on the Outcome of Psychiatric Disorders
- Author
-
de Castro-Catala, Marta, Papiol, Sergi, Barrantes-Vidal, Neus, Rosa, Araceli, Spalletta, Gianfranco, editor, Janiri, Delfina, editor, Piras, Federica, editor, and Sani, Gabriele, editor
- Published
- 2020
- Full Text
- View/download PDF
45. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
- Author
-
Mullins, Niamh, Forstner, Andreas J., O’Connell, Kevin S., Coombes, Brandon, Coleman, Jonathan R. I., Qiao, Zhen, Als, Thomas D., Bigdeli, Tim B., Børte, Sigrid, Bryois, Julien, Charney, Alexander W., Drange, Ole Kristian, Gandal, Michael J., Hagenaars, Saskia P., Ikeda, Masashi, Kamitaki, Nolan, Kim, Minsoo, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Steinberg, Stacy, Trubetskoy, Vassily, Winsvold, Bendik S., Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Agerbo, Esben, Al Eissa, Mariam, Albani, Diego, Alliey-Rodriguez, Ney, Anjorin, Adebayo, Antilla, Verneri, Antoniou, Anastasia, Awasthi, Swapnil, Baek, Ji Hyun, Bækvad-Hansen, Marie, Bass, Nicholas, Bauer, Michael, Beins, Eva C., Bergen, Sarah E., Birner, Armin, Bøcker Pedersen, Carsten, Bøen, Erlend, Boks, Marco P., Bosch, Rosa, Brum, Murielle, Brumpton, Ben M., Brunkhorst-Kanaan, Nathalie, Budde, Monika, Bybjerg-Grauholm, Jonas, Byerley, William, Cairns, Murray, Casas, Miquel, Cervantes, Pablo, Clarke, Toni-Kim, Cruceanu, Cristiana, Cuellar-Barboza, Alfredo, Cunningham, Julie, Curtis, David, Czerski, Piotr M., Dale, Anders M., Dalkner, Nina, David, Friederike S., Degenhardt, Franziska, Djurovic, Srdjan, Dobbyn, Amanda L., Douzenis, Athanassios, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Ferrier, I. Nicol, Fiorentino, Alessia, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Frei, Oleksandr, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Garnham, Julie, Gelernter, Joel, Giørtz Pedersen, Marianne, Gizer, Ian R., Gordon, Scott D., Gordon-Smith, Katherine, Greenwood, Tiffany A., Grove, Jakob, Guzman-Parra, José, Ha, Kyooseob, Haraldsson, Magnus, Hautzinger, Martin, Heilbronner, Urs, Hellgren, Dennis, Herms, Stefan, Hoffmann, Per, Holmans, Peter A., Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Kalman, Janos L., Kamatani, Yoichiro, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koromina, Maria, Kranz, Thorsten M., Kranzler, Henry R., Kubo, Michiaki, Kupka, Ralph, Kushner, Steven A., Lavebratt, Catharina, Lawrence, Jacob, Leber, Markus, Lee, Heon-Jeong, Lee, Phil H., Levy, Shawn E., Lewis, Catrin, Liao, Calwing, Lucae, Susanne, Lundberg, Martin, MacIntyre, Donald J., Magnusson, Sigurdur H., Maier, Wolfgang, Maihofer, Adam, Malaspina, Dolores, Maratou, Eirini, Martinsson, Lina, Mattheisen, Manuel, McCarroll, Steven A., McGregor, Nathaniel W., McGuffin, Peter, McKay, James D., Medeiros, Helena, Medland, Sarah E., Millischer, Vincent, Montgomery, Grant W., Moran, Jennifer L., Morris, Derek W., Mühleisen, Thomas W., O’Brien, Niamh, O’Donovan, Claire, Olde Loohuis, Loes M., Oruc, Lilijana, Papiol, Sergi, Pardiñas, Antonio F., Perry, Amy, Pfennig, Andrea, Porichi, Evgenia, Potash, James B., Quested, Digby, Raj, Towfique, Rapaport, Mark H., DePaulo, J. Raymond, Regeer, Eline J., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roth, Julian, Roussos, Panos, Ruderfer, Douglas M., Sánchez-Mora, Cristina, Schulte, Eva C., Senner, Fanny, Sharp, Sally, Shilling, Paul D., Sigurdsson, Engilbert, Sirignano, Lea, Slaney, Claire, Smeland, Olav B., Smith, Daniel J., Sobell, Janet L., Søholm Hansen, Christine, Soler Artigas, Maria, Spijker, Anne T., Stein, Dan J., Strauss, John S., Świątkowska, Beata, Terao, Chikashi, Thorgeirsson, Thorgeir E., Toma, Claudio, Tooney, Paul, Tsermpini, Evangelia-Eirini, Vawter, Marquis P., Vedder, Helmut, Walters, James T. R., Witt, Stephanie H., Xi, Simon, Xu, Wei, Yang, Jessica Mei Kay, Young, Allan H., Young, Hannah, Zandi, Peter P., Zhou, Hang, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Alfredsson, Lars, Babadjanova, Gulja, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Bengesser, Susanne, Berrettini, Wade H., Blackwood, Douglas H. R., Boehnke, Michael, Børglum, Anders D., Breen, Gerome, Carr, Vaughan J., Catts, Stanley, Corvin, Aiden, Craddock, Nicholas, Dannlowski, Udo, Dikeos, Dimitris, Esko, Tõnu, Etain, Bruno, Ferentinos, Panagiotis, Frye, Mark, Fullerton, Janice M., Gawlik, Micha, Gershon, Elliot S., Goes, Fernando S., Green, Melissa J., Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Henskens, Frans, Hillert, Jan, Hong, Kyung Sue, Hougaard, David M., Hultman, Christina M., Hveem, Kristian, Iwata, Nakao, Jablensky, Assen V., Jones, Ian, Jones, Lisa A., Kahn, René S., Kelsoe, John R., Kirov, George, Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Lochner, Christine, Loughland, Carmel, Martin, Nicholas G., Mathews, Carol A., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Michie, Patricia, Milani, Lili, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Mowry, Bryan, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nievergelt, Caroline M., Nordentoft, Merete, Nöthen, Markus M., O’Donovan, Michael C., Oedegaard, Ketil J., Olsson, Tomas, Owen, Michael J., Paciga, Sara A., Pantelis, Chris, Pato, Carlos, Pato, Michele T., Patrinos, George P., Perlis, Roy H., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Reininghaus, Eva Z., Ribasés, Marta, Rietschel, Marcella, Ripke, Stephan, Rouleau, Guy A., Saito, Takeo, Schall, Ulrich, Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Scott, Laura J., Scott, Rodney J., Serretti, Alessandro, Shannon Weickert, Cynthia, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Streit, Fabian, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne E., Vieta, Eduard, Vincent, John B., Waldman, Irwin D., Weickert, Thomas W., Werge, Thomas, Wray, Naomi R., Zwart, John-Anker, Biernacka, Joanna M., Nurnberger, John I., Cichon, Sven, Edenberg, Howard J., Stahl, Eli A., McQuillin, Andrew, Di Florio, Arianna, Ophoff, Roel A., and Andreassen, Ole A.
- Published
- 2021
- Full Text
- View/download PDF
46. Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum
- Author
-
Lago, Santiago G., Tomasik, Jakub, van Rees, Geertje F., Rubey, Marina, Gonzalez-Vioque, Emiliano, Ramsey, Jordan M., Haenisch, Frieder, Broek, Jantine A., Vázquez-Bourgon, Javier, Papiol, Sergi, Suarez-Pinilla, Paula, Ruland, Tillmann, Auyeug, Bonnie, Mikova, Olya, Kabacs, Nikolett, Arolt, Volker, Baron-Cohen, Simon, Crespo-Facorro, Benedicto, and Bahn, Sabine
- Published
- 2021
- Full Text
- View/download PDF
47. Improvement in daily functioning after aerobic exercise training in schizophrenia is sustained after exercise cessation
- Author
-
Falkai, Peter, Maurus, Isabel, Schmitt, Andrea, Malchow, Berend, Schneider-Axmann, Thomas, Röll, Lukas, Papiol, Sergi, Wobrock, Thomas, Hasan, Alkomiet, and Keeser, Daniel
- Published
- 2021
- Full Text
- View/download PDF
48. Utility of the MoCA for cognitive impairment screening in long-term psychosis patients
- Author
-
Ballesteros, Alejandro, Hernández, Rebeca, Janda, Lucía, Llano, Katia, López-Gil, José, López-Ilundain, José, Macaya, Patricia, Martínez-Parreño, Elena, Papiol, Sergi, Peralta, David, Ribeiro, María, Rosero, Ángela S., Saiz, Héctor, Gil-Berrozpe, Gustavo J., Sánchez-Torres, Ana M., García de Jalón, Elena, Moreno-Izco, Lucia, Fañanás, Lourdes, Peralta, Victor, and Cuesta, Manuel J.
- Published
- 2020
- Full Text
- View/download PDF
49. Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairment
- Author
-
Raabe, Florian, primary, Hausruckinger, Anna, additional, Gagliardi, Miriam, additional, Ahmad, Ruhel, additional, Almeida, Valeria, additional, Galinski, Sabrina, additional, Hoffmann, Anke, additional, Weigert, Liesa, additional, Rummel, Christine, additional, Murek, Vanessa, additional, Trastulla, Lucia, additional, Barron, Laura, additional, Atella, Alessia, additional, Maidl, Susanne, additional, Menegaz, Danusa, additional, Hauger, Barbara, additional, Wagner, Eva-Maria, additional, Gabellini, Nadia, additional, Kauschat, Beate, additional, Riccardo, Sara, additional, Cesana, Marcella, additional, Papiol, Sergi, additional, Sportelli, Vincenza, additional, Haffner, Monika, additional, Stolte, Sebastian, additional, Wehr, Michael, additional, Salcedo, Tatiana, additional, Papazova, Irina, additional, Wadleigh, Sevilla, additional, McMahon, Francis, additional, Schmitt, Andrea, additional, Falkai, Peter, additional, Hasan, Alkomiet, additional, Cacchiarelli, Davide, additional, Dannlowski, Udo, additional, Nenadi, Igor, additional, Kircher, Tilo, additional, Scheuss, Volker, additional, Eder, Matthias, additional, Binder, Elisabeth, additional, Spengler, Dietmar, additional, Rossner, Moritz J, additional, and Ziller, Michael J, additional
- Published
- 2024
- Full Text
- View/download PDF
50. Investigation of choroid plexus variability in schizophrenia-spectrum disorders - insights from a multimodal study
- Author
-
Yakimov, Vladislav, primary, Moussiopoulou, Joanna, additional, Roell, Lukas, additional, Mortazavi, Martin, additional, Jaeger, Iris, additional, Boudriot, Emanuel, additional, Hasanaj, Genc, additional, Campana, Mattia, additional, Krcmar, Lenka, additional, Kallweit, Marcel S., additional, Halstead, Sean, additional, Warren, Nicola, additional, Siskind, Dan, additional, Papiol, Sergi, additional, Maurus, Isabel, additional, Hasan, Alkomiet, additional, Falkai, Peter, additional, Schmitt, Andrea, additional, Raabe, Florian, additional, Keeser, Daniel, additional, and Wagner, Elias, additional
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.