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1. Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Author

Glöckner, Stephan, Sinnott, Richard O., Stell, Anthony, Fragoso, Maria C., Kastelan, Darko, Pupovac, Ivana D., Simunov, Bojana, Cazenave, Sarah, Haissaguerre, Magalie, Tabarin, Antoine, Bertherat, Jérôme, Libé, Rossella, Kienitz, Tina, Quinkler, Marcus, Langton, Katharina, Eisenhofer, Graeme, Beuschlein, Felix, Brugger, Christina, Reincke, Martin, Riester, Anna, Spyroglou, Ariadni, Burger-Stritt, Stephanie, Deutschbein, Timo, Fassnacht, Martin, Hahner, Stefanie, Kroiss, Matthias, Ronchi, Cristina L., Palimeri, Sotiria, Tsagarakis, Stylianos, Tsirou, Ioanna, Vassiliadi, Dimitra A., Basile, Vittoria, Ingargiola, Elisa, Reimondo, Giuseppe, Terzolo, Massimo, Canu, Letizia, Mannelli, Massimo, Ettaieb, Hester, Haak, Harm R., Kerkhofs, Thomas M., Biehl, Michael, Feelders, Richard A., Hofland, Johannes, Hofland, Leo J., Grytaas, Marianne A., Husebye, Eystein S., Ueland, Grethe A., Ambroziak, Urszula, Bednarczuk, Tomasz, Kondracka, Agnieszka, Macech, Magdalena, Zawierucha, Malgorzata, Paiva, Isabel, Dennedy, M. Conall, Sajwani, Ahmed, Sherlock, Mark, Crowley, Rachel K., Ivovic, Miomira, Marina, Ljiljana, Deeks, Jonathan J., Sitch, Alice J., Arlt, Wiebke, Bancos, Irina, Chortis, Vasileios, Giligan, Lorna C., Hughes, Beverly A., Lang, Katharina, Ivison, Hannah E., Jenkinson, Carl, Manolopoulos, Konstantinos, O'Neil, Donna M., O'Reilly, Michael W., Papathomas, Thomas G., Prete, Alessandro, Shackleton, Cedric H.L., Taylor, Angela E., Asia, Miriam, Sutcliffe, Robert P., Guest, Peter, Skordilis, Kassiani, Bancos, Cristian, Chang, Alice, Davidge-Pitts, Caroline J., Delivanis, Danae A., Erickson, Dana, Natt, Neena, Nippoldt, Todd B., Thomas, Melinda, Young Jr., William F., Taylor, Angela E, Sitch, Alice J, Davidge-Pitts, Caroline J, Pupovac, Ivana D, Papathomas, Thomas G, Gilligan, Lorna C, Grytaas, Marianne A, Ivison, Hannah E, Shackleton, Cedric H L, Ronchi, Cristina L, Delivanis, Danae A, Sutcliffe, Robert P, Feelders, Richard A, Haak, Harm R, Dennedy, M Conall, Ueland, Grethe A, Vassiliadi, Dimitra A, O'Reilly, Michael W, Young, William F, Jr, and Deeks, Jonathan J

Published
2020
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6. Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis

Author

Papathomas, Thomas G., Duregon, Eleonora, Korpershoek, Esther, Restuccia, David F., van Marion, Ronald, Cappellesso, Rocco, Sturm, Nathalie, Rossi, Giulio, Coli, Antonella, Zucchini, Nicola, Stoop, Hans, Oosterhuis, Wolter, Ventura, Laura, Volante, Marco, Fassina, Ambrogio, Dinjens, Winand N.M., Papotti, Mauro, and de Krijger, Ronald R.

Published
2016
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9. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Papathomas, Thomas G, Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J, van Nederveen, Francien, Tischler, Arthur S, Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J, Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J, Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne-Paule, Dinjens, Winand NM, Korpershoek, Esther, and de Krijger, Ronald R

Published
2015
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12. Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas

Author

Evenepoel, Lucie, van Nederveen, Francien H, Oudijk, Lindsey, Papathomas, Thomas G, Restuccia, David F, Belt, Eric J T, de Herder, Wouter W, Feelders, Richard A, Franssen, Gaston J H, Hamoir, Marc, Maiter, Dominique, Ghayee, Hans K, Shay, Jerry W, Perren, Aurel, Timmers, Henri J L M, van Eeden, Susanne, Vroonen, Laurent, Aydin, Selda, Robledo, Mercedes, Vikkula, Miikka, de Krijger, Ronald R, Dinjens, Winand N M, Persu, Alexandre, and Korpershoek, Esther

Published
2018

13. Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis

Author

Korpershoek, Esther, Koffy, Djamailys, Eussen, Bert H., Oudijk, Lindsey, Papathomas, Thomas G., van Nederveen, Francien H., Belt, Eric J. T., Franssen, Gaston J. H., Restuccia, David F. J., Krol, Niels M. G., van der Luijt, Rob B., Feelders, Richard A., Oldenburg, Rogier A., van Ijcken, Wilfred F. J., de Klein, Annelies, de Herder, Wouter W., de Krijger, Ronald R., and Dinjens, Winand N. M.

Published
2016

16. Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Author

Bancos, Irina, primary, Taylor, Angela E, additional, Chortis, Vasileios, additional, Sitch, Alice J, additional, Jenkinson, Carl, additional, Davidge-Pitts, Caroline J, additional, Lang, Katharina, additional, Tsagarakis, Stylianos, additional, Macech, Magdalena, additional, Riester, Anna, additional, Deutschbein, Timo, additional, Pupovac, Ivana D, additional, Kienitz, Tina, additional, Prete, Alessandro, additional, Papathomas, Thomas G, additional, Gilligan, Lorna C, additional, Bancos, Cristian, additional, Reimondo, Giuseppe, additional, Haissaguerre, Magalie, additional, Marina, Ljiljana, additional, Grytaas, Marianne A, additional, Sajwani, Ahmed, additional, Langton, Katharina, additional, Ivison, Hannah E, additional, Shackleton, Cedric H L, additional, Erickson, Dana, additional, Asia, Miriam, additional, Palimeri, Sotiria, additional, Kondracka, Agnieszka, additional, Spyroglou, Ariadni, additional, Ronchi, Cristina L, additional, Simunov, Bojana, additional, Delivanis, Danae A, additional, Sutcliffe, Robert P, additional, Tsirou, Ioanna, additional, Bednarczuk, Tomasz, additional, Reincke, Martin, additional, Burger-Stritt, Stephanie, additional, Feelders, Richard A, additional, Canu, Letizia, additional, Haak, Harm R, additional, Eisenhofer, Graeme, additional, Dennedy, M Conall, additional, Ueland, Grethe A, additional, Ivovic, Miomira, additional, Tabarin, Antoine, additional, Terzolo, Massimo, additional, Quinkler, Marcus, additional, Kastelan, Darko, additional, Fassnacht, Martin, additional, Beuschlein, Felix, additional, Ambroziak, Urszula, additional, Vassiliadi, Dimitra A, additional, O'Reilly, Michael W, additional, Young, William F, additional, Biehl, Michael, additional, Deeks, Jonathan J, additional, Arlt, Wiebke, additional, Glöckner, Stephan, additional, Sinnott, Richard O., additional, Stell, Anthony, additional, Fragoso, Maria C., additional, Pupovac, Ivana D., additional, Cazenave, Sarah, additional, Bertherat, Jérôme, additional, Libé, Rossella, additional, Brugger, Christina, additional, Hahner, Stefanie, additional, Kroiss, Matthias, additional, Ronchi, Cristina L., additional, Vassiliadi, Dimitra A., additional, Basile, Vittoria, additional, Ingargiola, Elisa, additional, Mannelli, Massimo, additional, Ettaieb, Hester, additional, Haak, Harm R., additional, Kerkhofs, Thomas M., additional, Feelders, Richard A., additional, Hofland, Johannes, additional, Hofland, Leo J., additional, Grytaas, Marianne A., additional, Husebye, Eystein S., additional, Ueland, Grethe A., additional, Zawierucha, Malgorzata, additional, Paiva, Isabel, additional, Dennedy, M. Conall, additional, Sherlock, Mark, additional, Crowley, Rachel K., additional, Deeks, Jonathan J., additional, Sitch, Alice J., additional, Bancos, Irina, additional, Giligan, Lorna C., additional, Hughes, Beverly A., additional, Ivison, Hannah E., additional, Manolopoulos, Konstantinos, additional, O'Neil, Donna M., additional, O'Reilly, Michael W., additional, Papathomas, Thomas G., additional, Shackleton, Cedric H.L., additional, Taylor, Angela E., additional, Sutcliffe, Robert P., additional, Guest, Peter, additional, Skordilis, Kassiani, additional, Chang, Alice, additional, Davidge-Pitts, Caroline J., additional, Delivanis, Danae A., additional, Natt, Neena, additional, Nippoldt, Todd B., additional, Thomas, Melinda, additional, and Young Jr., William F., additional

Published
2020
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20. What Have We Learned from Molecular Biology of Paragangliomas and Pheochromocytomas?

Author

Cancer, MS CGO, Heelkunde Opleiding, Pathologie Pathologen staf, Papathomas, Thomas G, Suurd, Diederik P D, Pacak, Karel, Tischler, Arthur S, Vriens, Menno R, Lam, Alfred K, de Krijger, Ronald R, Cancer, MS CGO, Heelkunde Opleiding, Pathologie Pathologen staf, Papathomas, Thomas G, Suurd, Diederik P D, Pacak, Karel, Tischler, Arthur S, Vriens, Menno R, Lam, Alfred K, and de Krijger, Ronald R

Published
2021

21. Data set for the reporting of pheochromocytoma and paraganglioma: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting

Author

Pathologie Patiëntenadministratie, Pathologie Pathologen staf, Thompson, Lester D.R., Gill, Anthony J., Asa, Sylvia L., Clifton-Bligh, Roderick J., de Krijger, Ronald R., Kimura, Noriko, Komminoth, Paul, Lack, Ernest E., Lenders, Jacques W.M., Lloyd, Ricardo V., Papathomas, Thomas G., Sadow, Peter M., Tischler, Arthur S., Pathologie Patiëntenadministratie, Pathologie Pathologen staf, Thompson, Lester D.R., Gill, Anthony J., Asa, Sylvia L., Clifton-Bligh, Roderick J., de Krijger, Ronald R., Kimura, Noriko, Komminoth, Paul, Lack, Ernest E., Lenders, Jacques W.M., Lloyd, Ricardo V., Papathomas, Thomas G., Sadow, Peter M., and Tischler, Arthur S.

Published
2021

24. Pseudosarcomatous myofibroblastic lesion of the urinary bladder: A rare entity posing a diagnostic challenge and therapeutic dilemma

Author

Deliveliotis Charalambos, Chrisofos Michail, Mennonna Maria, Papatsoris Athanasios G, Papathomas Thomas G, Parasi Aikaterini, Lekas Alexandros, and Lazaris Andreas C

Subjects
Pathology, RB1-214
Abstract

Abstract Background Pseudosarcomatous myofibroblastic lesions of the urinary bladder are relatively rare entities of an uncertain pathogenesis and benign indolent nature. Case presentation We present an extremely rare case of an ALK-1-positive pseudosarcomatous myofibroblastic lesion of the urinary bladder, which was initially misinterpreted as a low-grade leiomyosarcoma of myxoid subtype on histologic examination owing to prominent atypia, high mitotic activity, abnormal mitotic figures and infiltration of the bladder wall. Although the histologic features were suggestive of a sarcoma, the correct diagnosis was finally established and radical surgical treatment was subsequently avoided. The patient is currently free of disease without any evidence of tumor recurrence or metastasis at 3 years post-operatively. Conclusion The key differentiating point rests in distinguishing the aforementioned mass forming lesion from the myxoid subtype of low-grade leiomyosarcoma in order to avoid unnecessary radical therapy.

Published
2008
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25. Expression of Contactin 4 is associated with malignant behavior in pheochromocytomas and paragangliomas

Author

Aydin, Selda, Robledo, Mercedes, Restuccia, David F, Belt, Eric J T, Franssen, Gaston J H, De Krijger, Ronald R, Van Eeden, Susanne, De Herder, Wouter W, Vroonen, Laurent, Papathomas, Thomas G, Hamoir, Marc, Persu, Alexandre, Dinjens, Winand N M, Timmers, Henri J L M, Korpershoek, Esther, Evenepoel, Lucie, Maiter, Dominique, Van Nederveen, Francien H, Feelders, Richard A, Vikkula, Miikka, Oudijk, Lindsey, and Perren, Aurel

Subjects
570 Life sciences, biology, 610 Medicine & health
Abstract

Context Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine, usually benign tumors. Currently, the only reliable criterion of malignancy is the presence of metastases. Objective The aim was to identify genes associated with malignancy in PPGL. Design Transcriptomic profiling was performed on 40 benign and 11 malignant PPGL. Genes showing a significantly different expression between benign and malignant PPGL with a ratio ≥ 4 were confirmed, and subsequently tested in an independent series by qRT-PCR. Immunohistochemistry was performed for the validated genes on 109 benign and 32 malignant PPGL. Finally, functional assays were performed with hPheo1 cells. Setting Department of Pathology of the Erasmus MC University Medical Center Rotterdam; Human Molecular Genetics laboratory of the de Duve Institute, University of Louvain. Patients PPGL samples from 179 patients, diagnosed between 1972 and 2015 were included. Main outcome measures Associations between gene expression and malignancy were tested using supervised clustering approaches. Results Ten differentially expressed genes were selected based on mRNA expression array data. Contactin 4 was overexpressed in malignant vs. benign tumors (4.62-fold, FDR: 0.001). Overexpression at the mRNA level was confirmed using qRT-PCR (2.90-fold, p=0.02; validation set: 4.26-fold, p=0.005). Consistent findings were obtained in the TCGA cohort (2.7-fold, FDR: 0.02). Furthermore, Contactin 4 protein was more frequently expressed in malignant than in benign PPGL by immunohistochemistry (58% vs. 17%, p=0.002). Finally, survival after 7 days of culture under starvation conditions was significantly enhanced in hPheo1 cells transfected with CNTN4 cDNA. Conclusion CNTN4 expression is consistently associated with malignant behavior in PPGL.

Published
2018
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26. Expression of Contactin 4 is associated with malignant behavior in pheochromocytomas and paragangliomas.

Author

UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - (SLuc) Centre du cancer, Evenepoel, Lucie, van Nederveen, Francien H, Oudijk, Lindsey, Papathomas, Thomas G, Restuccia, David F, Belt, Eric J T, de Herder, Wouter W, Feelders, Richard A, Franssen, Gaston J H, Hamoir, Marc, Maiter, Dominique, Perren, Aurel, Timmers, Henri J L M, van Eeden, Susanne, Vroonen, Laurent, Aydin, Selda, Robledo, Mercedes, Vikkula, Miikka, de Krijger, Ronald R, Dinjens, Winand N M, Persu, Alexandre, Korpershoek, Esther, UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - (SLuc) Centre du cancer, Evenepoel, Lucie, van Nederveen, Francien H, Oudijk, Lindsey, Papathomas, Thomas G, Restuccia, David F, Belt, Eric J T, de Herder, Wouter W, Feelders, Richard A, Franssen, Gaston J H, Hamoir, Marc, Maiter, Dominique, Perren, Aurel, Timmers, Henri J L M, van Eeden, Susanne, Vroonen, Laurent, Aydin, Selda, Robledo, Mercedes, Vikkula, Miikka, de Krijger, Ronald R, Dinjens, Winand N M, Persu, Alexandre, and Korpershoek, Esther

Abstract

Context: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine, usually benign, tumors. Currently, the only reliable criterion of malignancy is the presence of metastases. Objective: The aim of this study was to identify genes associated with malignancy in PPGLs. Design: Transcriptomic profiling was performed on 40 benign and 11 malignant PPGLs. Genes showing a significantly different expression between benign and malignant PPGLs with a ratio ≥4 were confirmed and tested in an independent series by quantitative real-time polymerase chain reaction (qRT-PCR). Immunohistochemistry was performed for the validated genes on 109 benign and 32 malignant PPGLs. Functional assays were performed with hPheo1 cells. Setting: This study was conducted at the Department of Pathology of the Erasmus MC University Medical Center Rotterdam Human Molecular Genetics laboratory of the de Duve Institute, University of Louvain. Patients: PPGL samples from 179 patients, diagnosed between 1972 and 2015, were included. Main outcome measures: Associations between gene expression and malignancy were tested using supervised clustering approaches. Results: Ten differentially expressed genes were selected based on messenger RNA (mRNA) expression array data. Contactin 4 (CNTN4) was overexpressed in malignant vs benign tumors [4.62-fold; false discovery rate (FDR), 0.001]. Overexpression at the mRNA level was confirmed using qRT-PCR (2.90-fold, P = 0.02; validation set: 4.26-fold, P = 0.005). Consistent findings were obtained in The Cancer Genome Atlas cohort (2.7-fold; FDR, 0.02). CNTN4 protein was more frequently expressed in malignant than in benign PPGLs by immunohistochemistry (58% vs 17%; P = 0.002). Survival after 7 days of culture under starvation conditions was significantly enhanced in hPheo1 cells transfected with CNTN4 complementary DNA. Conclusion: CNTN4 expression is consistently associated with malignant behavior in PPGLs.

Published
2018

28. Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas

Author

Evenepoel, Lucie, primary, van Nederveen, Francien H, additional, Oudijk, Lindsey, additional, Papathomas, Thomas G, additional, Restuccia, David F, additional, Belt, Eric J T, additional, de Herder, Wouter W, additional, Feelders, Richard A, additional, Franssen, Gaston J H, additional, Hamoir, Marc, additional, Maiter, Dominique, additional, Ghayee, Hans K, additional, Shay, Jerry W, additional, Perren, Aurel, additional, Timmers, Henri J L M, additional, van Eeden, Susanne, additional, Vroonen, Laurent, additional, Aydin, Selda, additional, Robledo, Mercedes, additional, Vikkula, Miikka, additional, de Krijger, Ronald R, additional, Dinjens, Winand N M, additional, Persu, Alexandre, additional, and Korpershoek, Esther, additional

Published
2017
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29. SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity

Author

Casey, Ruth T., primary, Ascher, David B., additional, Rattenberry, Eleanor, additional, Izatt, Louise, additional, Andrews, Katrina A., additional, Simpson, Helen L., additional, Challis, Benjamen, additional, Park, Soo-Mi, additional, Bulusu, Venkata R., additional, Lalloo, Fiona, additional, Pires, Douglas E. V., additional, West, Hannah, additional, Clark, Graeme R., additional, Smith, Philip S., additional, Whitworth, James, additional, Papathomas, Thomas G., additional, Taniere, Phillipe, additional, Savisaar, Rosina, additional, Hurst, Laurence D., additional, Woodward, Emma R., additional, and Maher, Eamonn R., additional

Published
2017
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30. An international Ki67 reproducibility study in adrenal cortical Carcinoma

Author

Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., De Krijger, Ronald R., Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., and De Krijger, Ronald R.

Published
2016

31. Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis

Author

Pathologie patiënten zorg, Papathomas, Thomas G., Duregon, Eleonora, Korpershoek, Esther, Restuccia, David F., van Marion, Ronald, Cappellesso, Rocco, Sturm, Nathalie, Rossi, Giulio, Coli, Antonella, Zucchini, Nicola, Stoop, Hans, Oosterhuis, Wolter, Ventura, Laura, Volante, Marco, Fassina, Ambrogio, Dinjens, Winand N M, Papotti, Mauro, de Krijger, Ronald R., Pathologie patiënten zorg, Papathomas, Thomas G., Duregon, Eleonora, Korpershoek, Esther, Restuccia, David F., van Marion, Ronald, Cappellesso, Rocco, Sturm, Nathalie, Rossi, Giulio, Coli, Antonella, Zucchini, Nicola, Stoop, Hans, Oosterhuis, Wolter, Ventura, Laura, Volante, Marco, Fassina, Ambrogio, Dinjens, Winand N M, Papotti, Mauro, and de Krijger, Ronald R.

Published
2016

32. An international Ki67 reproducibility study in adrenal cortical Carcinoma

Author

Pathologie patiënten zorg, Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., De Krijger, Ronald R., Pathologie patiënten zorg, Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., and De Krijger, Ronald R.

Published
2016

33. An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma

Author

Papathomas, Thomas G., primary, Pucci, Eugenio, additional, Giordano, Thomas J., additional, Lu, Hao, additional, Duregon, Eleonora, additional, Volante, Marco, additional, Papotti, Mauro, additional, Lloyd, Ricardo V., additional, Tischler, Arthur S., additional, van Nederveen, Francien H., additional, Nose, Vania, additional, Erickson, Lori, additional, Mete, Ozgur, additional, Asa, Sylvia L., additional, Turchini, John, additional, Gill, Anthony J., additional, Matias-Guiu, Xavier, additional, Skordilis, Kassiani, additional, Stephenson, Timothy J., additional, Tissier, Frédérique, additional, Feelders, Richard A., additional, Smid, Marcel, additional, Nigg, Alex, additional, Korpershoek, Esther, additional, van der Spek, Peter J., additional, Dinjens, Winand N.M., additional, Stubbs, Andrew P., additional, and de Krijger, Ronald R., additional

Published
2016
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35. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas : A multicenter interobserver variation analysis using virtual microscopy: A Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, De Krijger, Ronald R., Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, and De Krijger, Ronald R.

Published
2015

36. Succinate dehydrogenase (SDH)-deficient pancreatic neuroendocrine tumor expands the SDH-related tumor spectrum

Author

Pathologie patiënten zorg, Genetica Klinische Genetica, Niemeijer, Nicolasine D., Papathomas, Thomas G., Korpershoek, Esther, De Krijger, Ronald R., Oudijk, Lindsey, Morreau, Hans, Bayley, Jean Pierre, Hes, Frederik J., Jansen, Jeroen C., Dinjens, Winand N M, Corssmit, Eleonora P M, Pathologie patiënten zorg, Genetica Klinische Genetica, Niemeijer, Nicolasine D., Papathomas, Thomas G., Korpershoek, Esther, De Krijger, Ronald R., Oudijk, Lindsey, Morreau, Hans, Bayley, Jean Pierre, Hes, Frederik J., Jansen, Jeroen C., Dinjens, Winand N M, and Corssmit, Eleonora P M

Published
2015

38. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: A multicenter interobserver variation analysis using virtual microscopy: A Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Pathologie patiënten zorg, Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, De Krijger, Ronald R., Pathologie patiënten zorg, Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, and De Krijger, Ronald R.

Published
2015

39. Cytokeratin-7, cytokeratin-19, and c-Kit: Immunoreaction during the evolution stages of primary biliary cirrhosis

Author

Chatzipantelis, Paschalis Lazaris, Andreas C. Kafiri, Georgia and Papadimitriou, Konstandina Papathomas, Thomas G. Nonni, Aphrodite Patsouris, Efstratios S.

Abstract

Aims: The quantitative and qualitative expression of CK-7, CK-19, and c-Kit markers in various cell types were evaluated during the four stages of primary biliary cirrhosis. Methods: A total of 53 specimens were examined. Thirteen specimens were identified as Ludwig’s stage 1, 23 as stage 2, 14 as stage 3, and 2 as stage 4. Immunohistochemical stains were performed for CK-7, CK-19, c-Kit and subsequently graded. The cell types expressing the markers were qualitatively analysed. Results: In normal liver, biliary epithelial cells expressed CK-7, CK-19, whereas the Canals of Hering (CoH) were stained with c-Kit and partly CK-19, contrary to hepatocytes. The aforementioned expression patterns were detected in pathologic samples of PBC, with qualitative and quantitative differences though. CK-7 grading was found to correspond with Ludwig’s staging, in contrast to CK-19. c-Kit was absent in the early stages and focally present in the advanced stages. All biliary-type, intermediate cells and hepatocytes were CK-7 positive, particularly in samples with cholestasis, whereas CK-19 was only found in biliary-type and intermediate cells. c-Kit was expressed in CoH which appeared as clusters and strings of cuboidal cells in advanced stages. Conclusions: CK-7 can be regarded as a histological marker of progression in PBC; CK-19 cannot be assessed as a safe marker in the development of the disease. The absence of c-Kit in the early stages of PBC is related to the destruction of the CoH. CK-7 hepatocyte expression in the advanced stages is likely to be related to damaged hepatocytes’ metaplastic potential. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

Published
2006

41. Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia

Author

Papathomas, Thomas G, primary, Oudijk, Lindsey, additional, Zwarthoff, Ellen C, additional, Post, Edward, additional, Duijkers, Floor A, additional, van Noesel, Max M, additional, Hofland, Leo J, additional, Pollard, Patrick J, additional, Maher, Eamonn R, additional, Restuccia, David F, additional, Feelders, Richard A, additional, Franssen, Gaston J H, additional, Timmers, Henri J, additional, Sleijfer, Stefan, additional, de Herder, Wouter W, additional, de Krijger, Ronald R, additional, Dinjens, Winand N M, additional, and Korpershoek, Esther, additional

Published
2014
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43. Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC–PGL syndromes: a clinicopathological and molecular analysis

Author

Papathomas, Thomas G, primary, Gaal, Jose, additional, Corssmit, Eleonora P M, additional, Oudijk, Lindsey, additional, Korpershoek, Esther, additional, Heimdal, Ketil, additional, Bayley, Jean-Pierre, additional, Morreau, Hans, additional, van Dooren, Marieke, additional, Papaspyrou, Konstantinos, additional, Schreiner, Thomas, additional, Hansen, Torsten, additional, Andresen, Per Arne, additional, Restuccia, David F, additional, van Kessel, Ingrid, additional, van Leenders, Geert J L H, additional, Kros, Johan M, additional, Looijenga, Leendert H J, additional, Hofland, Leo J, additional, Mann, Wolf, additional, van Nederveen, Francien H, additional, Mete, Ozgur, additional, Asa, Sylvia L, additional, de Krijger, Ronald R, additional, and Dinjens, Winand N M, additional

Published
2014
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48. Potential Role of Apoptosis and Apoptotic Regulatory Proteins in Colorectal Neoplasia: Correlations with Clinico-Pathological Parameters and Survival

Author

Tzouvala, Maria, primary, Lazaris, Andreas C., additional, Papatheodoridis, George V., additional, Kouvidou, Chariklia, additional, Papathomas, Thomas G., additional, Kavantzas, Nikos, additional, Elemenoglou, Ioannis, additional, Karamanolis, Demetrios G., additional, and Agapitos, Emmanouil, additional

Published
2007
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49. Automated Selection of Hotspots (ASH): enhanced automated segmentation and adaptive step finding for Ki67 hotspot detection in adrenal cortical cancer

Author

Hao Lu, Papathomas, Thomas G, van Zessen, David, Palli, Ivo, de Krijger, Ronald R, van der Spek, Peter J, Dinjens, Winand NM, and Stubbs, Andrew P

Abstract

Background: In prognosis and therapeutics of adrenal cortical carcinoma (ACC), the selection of the most active areas in proliferative rate (hotspots) within a slide and objective quantification of immunohistochemical Ki67 Labelling Index (LI) are of critical importance. In addition to intratumoral heterogeneity in proliferative rate i.e. levels of Ki67 expression within a given ACC, lack of uniformity and reproducibility in the method of quantification of Ki67 LI may confound an accurate assessment of Ki67 LI. Results: We have implemented an open source toolset, Automated Selection of Hotspots (ASH), for automated hotspot detection and quantification of Ki67 LI. ASH utilizes NanoZoomer Digital Pathology Image (NDPI) splitter to convert the specific NDPI format digital slide scanned from the Hamamatsu instrument into a conventional tiff or jpeg format image for automated segmentation and adaptive step finding hotspots detection algorithm. Quantitative hotspot ranking is provided by the functionality from the open source application ImmunoRatio as part of the ASH protocol. The output is a ranked set of hotspots with concomitant quantitative values based on whole slide ranking. Conclusion: We have implemented an open source automated detection quantitative ranking of hotspots to support histopathologists in selecting the ‘hottest’ hotspot areas in adrenocortical carcinoma. To provide wider community easy access to ASH we implemented a Galaxy virtual machine (VM) of ASH which is available from http://bioinformatics.erasmusmc.nl/wiki/Automated_Selection_of_Hotspots. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.

Author

Papathomas TG, Gaal J, Corssmit EP, Oudijk L, Korpershoek E, Heimdal K, Bayley JP, Morreau H, van Dooren M, Papaspyrou K, Schreiner T, Hansen T, Andresen PA, Restuccia DF, van Kessel I, van Leenders GJ, Kros JM, Looijenga LH, Hofland LJ, Mann W, van Nederveen FH, Mete O, Asa SL, de Krijger RR, and Dinjens WN

Subjects
Adenoma metabolism, Adenoma pathology, Adult, Carcinoma genetics, Carcinoma metabolism, Carcinoma pathology, Carcinoma, Papillary genetics, Carcinoma, Papillary metabolism, Carcinoma, Papillary pathology, Carcinoma, Renal Cell metabolism, Carcinoma, Renal Cell pathology, Exons, Female, Gene Deletion, Germ-Line Mutation, Humans, Loss of Heterozygosity, Male, Middle Aged, Neoplasm Proteins genetics, Neoplasm Proteins metabolism, Pituitary Neoplasms metabolism, Pituitary Neoplasms pathology, Succinate Dehydrogenase metabolism, Thyroid Cancer, Papillary, Thyroid Neoplasms metabolism, Thyroid Neoplasms pathology, Adenoma genetics, Carcinoma, Renal Cell genetics, Mutation, Pituitary Neoplasms genetics, Succinate Dehydrogenase genetics, Thyroid Neoplasms genetics
Abstract

Objective: Although the succinate dehydrogenase (SDH)-related tumor spectrum has been recently expanded, there are only rare reports of non-pheochromocytoma/paraganglioma tumors in SDHx-mutated patients. Therefore, questions still remain unresolved concerning the aforementioned tumors with regard to their pathogenesis, clinicopathological phenotype, and even causal relatedness to SDHx mutations. Absence of SDHB expression in tumors derived from tissues susceptible to SDH deficiency is not fully elucidated., Design and Methods: Three unrelated SDHD patients, two with pituitary adenoma (PA) and one with papillary thyroid carcinoma (PTC), and three SDHB patients affected by renal cell carcinomas (RCCs) were identified from four European centers. SDHA/SDHB immunohistochemistry (IHC), SDHx mutation analysis, and loss of heterozygosity analysis of the involved SDHx gene were performed on all tumors. A cohort of 348 tumors of unknown SDHx mutational status, including renal tumors, PTCs, PAs, neuroblastic tumors, seminomas, and adenomatoid tumors, was investigated by SDHB IHC., Results: Of the six index patients, all RCCs and one PA displayed SDHB immunonegativity in contrast to the other PA and PTC. All immunonegative tumors demonstrated loss of the WT allele, indicating bi-allelic inactivation of the germline mutated gene. Of 348 tumors, one clear cell RCC exhibited partial loss of SDHB expression., Conclusions: These findings strengthen the etiological association of SDHx genes with pituitary neoplasia and provide evidence against a link between PTC and SDHx mutations. Somatic deletions seem to constitute the second hit in SDHB-related renal neoplasia, while SDHx alterations do not appear to be primary drivers in sporadic tumorigenesis from tissues affected by SDH deficiency.

Published
2013
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