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22 results on '"Papathomas, K"'

15. Development of Conductive Adhesive Materials for via Fill Applications.

Author

Sung K. Kang, Buchwalter, Stephen L., LaBianca, Nancy C., Gelorme, J., Purushothaman, Sampath, Papathomas, K., and Poliks, M.

Subjects
PRINTED circuits, MINIATURE electronic equipment bonding, HOLES (Electron deficiencies), DESIGN
Abstract

Details the development of lead-free electrically conducting adhesive material to be used for via filling in printed circuit boards. Generic process for the build-up multilayer technology; Development of a class of conductive adhesive materials; Measurement of the bulk properties of the conducting adhesive materials.

Published
2001
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19. Luminescence of W(CO)<INF>4</INF>(4-Me-phen) in Photosensitive Thin Films:  A Molecular Probe of Acrylate Polymerization

Author

Rawlins, K. A., Lees, A. J., Fuerniss, S. J., and Papathomas, K. I.

Abstract

The complex W(CO)4(4-Me-phen) (4-Me-phen = 4-methyl-1,10-phenanthroline) has been determined to be luminescent and act as a spectroscopic probe in UV-curable trimethylolpropane triacrylate/poly(methyl methacrylate) thin films. Electronic absorption and luminescence characteristics have been measured for this complex in room-temperature solutions and low-temperature (80 K) glasses and in 10 mil thin films of the unexposed and exposed acrylate resins. In each environment dual luminescence bands were observed which are attributed to triplet-centered metal-to-ligand charge-transfer (3MLCT) excited states. For the unexposed photoresist these transitions were recorded at 520 and 750 nm and in the exposed material these are moved to 525 and 715 nm, respectively. The lowest energy emission band undergoes a substantial blue-shift and intensifies greatly on polymerization; this phenomenon provides a useful molecular probe of the acrylate cross-linking process. These changes in emission characteristics are associated with a rigidochromic effect imparted on the lowest lying and solvent sensitive b2 → b2(π*) 3MLCT electronically excited state in this complex. The complex W(CO)5(4-CN-py) (4-CN-py = 4-cyanopyridine) was also investigated as a spectroscopic probe in the acrylate system but appears unsuitable for this purpose as it was found to degrade significantly in the resin.

Published
1996

22. Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model.

Author

Gutierrez LS, Ling J, Nye D, Papathomas K, and Dickinson C

Subjects
Animals, Antigens, CD34 metabolism, Biomarkers blood, Colitis, Ulcerative blood, Colitis, Ulcerative chemically induced, Colitis, Ulcerative genetics, Colitis, Ulcerative pathology, Colon blood supply, Colon metabolism, Colon pathology, Dextran Sulfate, Disease Models, Animal, Inflammation Mediators blood, Interleukin-6 blood, Mice, Knockout, Microvessels drug effects, Microvessels metabolism, Microvessels pathology, Phosphorylation, Platelet Endothelial Cell Adhesion Molecule-1 metabolism, STAT3 Transcription Factor metabolism, Thrombospondin 1 deficiency, Thrombospondin 1 genetics, Anti-Inflammatory Agents pharmacology, Colitis, Ulcerative drug therapy, Colon drug effects, Neovascularization, Pathologic, Oligopeptides pharmacology, Proteins pharmacology
Abstract

Aim: To evaluate the efficacy of the improved thrombospondin mimetic peptide ABT-898 in a murine model of ulcerative colitis., Methods: The dextran sodium sulfate (DSS) was used for the induction of colitis in both TSP-1 deficient (TSP-1(-/-)) and wild type (WT) mice during 7 d. While mice were receiving the DSS dissolved in the drinking water, the ABT-898 peptide was dissolved in sterile 5% glucose solution and delivered using mini pumps subcutaneously implanted. Plasma samples were analyzed for interleukin (IL)-6 by ELISA assay and colonic tissues were harvested, fixed and processed for histological evaluation. Immunohistochemistry using antibodies for the detection of CD31 and MECA in endothelial cells was performed. Inflammation was graded in colonic sections and the number of microvessels in each lesion was assessed. Activation of signal transducer and activator of transcription 3 (STAT3) in colonic samples was quantified by immunohistochemistry and Western blotting using antibodies against total STAT3 and phosphorylated STAT3 (pSTAT3) (Ser727)., Results: Treatment with ABT-898 considerably diminished the inflammatory response in WT and TSP-1(-/-) mice (P < 0.0001 in both groups vs control). Identification of blood vessels highlighted by CD31/MECA immunohistochemistry, showed significantly reduced vessel counts in colitic lesions of WT and TSP-1(-/-) mice treated with ABT898 (TSP-1(-/-) controls/TSP-1(-/-) treated, P = 0.0002; WT controls/WT treated, P = 0.0005). Consistently, IL-6 was significantly diminished in plasma samples of TSP-1(-/-) and WT treated with the peptide when compared to the control mice (P = 0.0002 and P = 0.0148, respectively). pSTAT3 positive cells were quantified in WT and TSP-1(-/-) treated with ABT-898. A significant decrease in positive cells for pSTAT3 was observed in treated mice (TSP-1(-/-) controls/TSP-1(-/-) treated, P = 0.0089; WT/WT treated, P = 0.0110). These results were confirmed by Western blotting analyses showing lower levels of pSTAT3 in colitic lesions from mice treated with the peptide ABT-898., Conclusion: These findings indicate that the new peptide ABT-898 ameliorates inflammation and angiogenesis and might be a therapeutic alternative in IBD and inflammatory diseases.

Published
2015
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