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747 results on '"Papassotiropoulos, Andreas"'

8. NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors

Author

Vukojevic, Vanja, Coynel, David, Ghaffari, Navid R, Freytag, Virginie, Elbert, Thomas, Kolassa, Iris-Tatjana, Wilker, Sarah, McGaugh, James L, Papassotiropoulos, Andreas, and de Quervain, Dominique J-F

Subjects
Biological Psychology, Psychology, Brain Disorders, Post-Traumatic Stress Disorder (PTSD), Anxiety Disorders, Mental Health, Prevention, Clinical Research, Neurosciences, Genetics, Mental health, Adult, Aged, Brain, DNA Methylation, Epigenesis, Genetic, Female, Glucocorticoids, Humans, Male, Membrane Glycoproteins, Memory, Middle Aged, Polymorphism, Single Nucleotide, Receptor, trkB, Receptors, Glucocorticoid, Risk Factors, Rwanda, Stress Disorders, Post-Traumatic, Survivors, Uganda, PTSD, glucocorticoids, memory, epigenetics, NTRK2
Abstract

Extensive pharmacologic, genetic, and epigenetic research has linked the glucocorticoid receptor (GR) to memory processes, and to risk and symptoms of posttraumatic stress disorder (PTSD). In the present study we investigated the epigenetic pattern of 12 genes involved in the regulation of GR signaling in two African populations of heavily traumatized individuals: Survivors of the rebel war in northern Uganda (n = 463) and survivors of the Rwandan genocide (n = 350). The strongest link between regional methylation and PTSD risk and symptoms was observed for NTRK2, which encodes the transmembrane receptor tropomyosin-related kinase B, binds the brain-derived neurotrophic factor, and has been shown to play an important role in memory formation. NTRK2 methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. Because NTRK2 methylation differences were predominantly associated with memory-related PTSD symptoms, and because they seem to precede traumatic events, we next investigated the relationship between NTRK2 methylation and memory in a sample of nontraumatized individuals (n = 568). We found that NTRK2 methylation was negatively associated with recognition memory performance. Furthermore, fMRI analyses revealed NTRK2 methylation-dependent differences in brain network activity related to recognition memory. The present study demonstrates that NTRK2 is epigenetically linked to memory functions in nontraumatized subjects and to PTSD risk and symptoms in traumatized populations.

Published
2020

9. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M, Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K, Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L, Buitelaar, Jan, Celius, Elisabeth G, Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M, de Quervain, Dominique JF, Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S, Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K, Harbo, Hanne F, Hartman, Catharina A, Heslenfeld, Dirk, Hoekstra, Pieter J, Høgestøl, Einar A, Jernigan, Terry L, Jonassen, Rune, Jönsson, Erik G, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J, Maglanoc, Luigi A, Malt, Ulrik F, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B, Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbæk, Geir, Shadrin, Alexey A, Smeland, Olav B, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M, Tsolaki, Magda, Ulrichsen, Kristine M, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C, Zink, Mathias, Andreassen, Ole A, and Westlye, Lars T

Subjects
Biological Psychology, Psychology, Rare Diseases, Mental Health, Neurosciences, Brain Disorders, Biomedical Imaging, Aging, Aetiology, 2.3 Psychological, social and economic factors, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Neurological, Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Brain, Brain Diseases, Child, Child, Preschool, Female, Genome-Wide Association Study, Humans, Infant, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuropsychological Tests, Schizophrenia, Sex Characteristics, Young Adult, Karolinska Schizophrenia Project, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Published
2019

12. Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory

Author

Atucha, Erika, Vukojevic, Vanja, Fornari, Raquel V, Ronzoni, Giacomo, Demougin, Philippe, Peter, Fabian, Atsak, Piray, Coolen, Marcel W, Papassotiropoulos, Andreas, McGaugh, James L, de Quervain, Dominique J-F, and Roozendaal, Benno

Subjects
Mental Health, Behavioral and Social Science, Neurosciences, Basic Behavioral and Social Science, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Mental health, Adrenergic alpha-Agonists, Animals, Avoidance Learning, Basolateral Nuclear Complex, Cell Adhesion Molecules, Neuronal, DNA Methylation, Discrimination, Psychological, Extracellular Matrix Proteins, GABA-A Receptor Agonists, Hippocampus, Male, Memory, Long-Term, Muscimol, Nerve Tissue Proteins, Norepinephrine, Rats, Sprague-Dawley, Reelin Protein, Serine Endopeptidases, Transcriptome, basolateral amygdala, norepinephrine, memory accuracy, hippocampus, systems consolidation
Abstract

Emotional enhancement of memory by noradrenergic mechanisms is well-described, but the long-term consequences of such enhancement are poorly understood. Over time, memory traces are thought to undergo a neural reorganization, that is, a systems consolidation, during which they are, at least partly, transferred from the hippocampus to neocortical networks. This transfer is accompanied by a decrease in episodic detailedness. Here we investigated whether norepinephrine (NE) administration into the basolateral amygdala after training on an inhibitory avoidance discrimination task, comprising two distinct training contexts, alters systems consolidation dynamics to maintain episodic-like accuracy and hippocampus dependency of remote memory. At a 2-d retention test, both saline- and NE-treated rats accurately discriminated the training context in which they had received footshock. Hippocampal inactivation with muscimol before retention testing disrupted discrimination of the shock context in both treatment groups. At 28 d, saline-treated rats showed hippocampus-independent retrieval and lack of discrimination. In contrast, NE-treated rats continued to display accurate memory of the shock-context association. Hippocampal inactivation at this remote retention test blocked episodic-like accuracy and induced a general memory impairment. These findings suggest that the NE treatment altered systems consolidation dynamics by maintaining hippocampal involvement in the memory. This shift in systems consolidation was paralleled by time-regulated DNA methylation and transcriptional changes of memory-related genes, namely Reln and Pkmζ, in the hippocampus and neocortex. The findings provide evidence suggesting that consolidation of emotional memories by noradrenergic mechanisms alters systems consolidation dynamics and, as a consequence, influences the maintenance of long-term episodic-like accuracy of memory.

Published
2017

13. Genetic control of variability in subcortical and intracranial volumes

Author

Córdova-Palomera, Aldo, van der Meer, Dennis, Kaufmann, Tobias, Bettella, Francesco, Wang, Yunpeng, Alnæs, Dag, Doan, Nhat Trung, Agartz, Ingrid, Bertolino, Alessandro, Buitelaar, Jan K., Coynel, David, Djurovic, Srdjan, Dørum, Erlend S., Espeseth, Thomas, Fazio, Leonardo, Franke, Barbara, Frei, Oleksandr, Håberg, Asta, Le Hellard, Stephanie, Jönsson, Erik G., Kolskår, Knut K., Lund, Martina J., Moberget, Torgeir, Nordvik, Jan E., Nyberg, Lars, Papassotiropoulos, Andreas, Pergola, Giulio, de Quervain, Dominique, Rampino, Antonio, Richard, Genevieve, Rokicki, Jaroslav, Sanders, Anne-Marthe, Schwarz, Emanuel, Smeland, Olav B., Steen, Vidar M., Starrfelt, Jostein, Sønderby, Ida E., Ulrichsen, Kristine M., Andreassen, Ole A., and Westlye, Lars T.

Published
2021
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18. Role for Glyoxalase I in Alzheimer's Disease

Author

Chen, Feng, Wollmer, M. Axel, Hoerndli, Frederic, Münch, Gerald, Kuhla, Björn, Rogaev, Evgeny I., Tsolaki, Magdalini, Papassotiropoulos, Andreas, Götz, Jürgen, and Baulieu, Etienne-Emile

Published
2004

23. Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder

Author

Schwarz, Emanuel, Doan, Nhat Trung, Pergola, Giulio, Westlye, Lars T, Kaufmann, Tobias, Wolfers, Thomas, Brecheisen, Ralph, Quarto, Tiziana, Ing, Alex J, Di Carlo, Pasquale, Gurholt, Tiril P, Harms, Robbert L, Noirhomme, Quentin, Moberget, Torgeir, Agartz, Ingrid, Andreassen, Ole A, Bellani, Marcella, Bertolino, Alessandro, Blasi, Giuseppe, Brambilla, Paolo, Buitelaar, Jan K, Cervenka, Simon, Flyckt, Lena, Frangou, Sophia, Franke, Barbara, Hall, Jeremy, Heslenfeld, Dirk J, Kirsch, Peter, McIntosh, Andrew M, Nöthen, Markus M, Papassotiropoulos, Andreas, de Quervain, Dominique J-F, Rietschel, Marcella, Schumann, Gunter, Tost, Heike, Witt, Stephanie H, Zink, Mathias, Meyer-Lindenberg, Andreas, and The IMAGEMEND Consortium, Karolinska Schizophrenia Project (KaSP) Consortium

Published
2019
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36. Human genome–guided identification of memory-modulating drugs

Author

Papassotiropoulos, Andreas, Gerhards, Christiane, Heck, Angela, Ackermann, Sandra, Aerni, Amanda, Schicktanz, Nathalie, Auschra, Bianca, Demougin, Philippe, Mumme, Eva, Elbert, Thomas, Ertl, Verena, Gschwind, Leo, Hanser, Edveena, Huynh, Kim-Dung, Jessen, Frank, Kolassa, Iris-Tatjana, Milnik, Annette, Paganetti, Paolo, Spalek, Klara, Vogler, Christian, Muhs, Andreas, Pfeifer, Andrea, and de Quervain, Dominique J.-F.

Published
2013

39. PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors

Author

de Quervain, Dominique J.-F., Kolassa, Iris-Tatjana, Ackermann, Sandra, Aerni, Amanda, Boesiger, Peter, Demougin, Philippe, Elbert, Thomas, Ertl, Verena, Gschwind, Leo, Hadziselimovic, Nils, Hanser, Edveena, Heck, Angela, Hieber, Petra, Huynh, Kim-Dung, Klarhöfer, Markus, Luechinger, Roger, Rasch, Björn, Scheffler, Klaus, Spalek, Klara, Stippich, Christoph, Vogler, Christian, Vukojevic, Vanja, Stetak, Attila, and Papassotiropoulos, Andreas

Published
2012

41. Phosphorylation of MSI-1 is implicated in the regulation of associative memory in Caenorhabditis elegans

Author

Mastrandreas, Pavlina, Boglari, Csaba, Arnold, Andreas, Peter, Fabian, de Quervain, Dominique J.-F., Papassotiropoulos, Andreas, and Stetak, Attila

Abstract

The Musashi family of RNA-binding proteins controls several biological processes including stem cell maintenance, cell division and neural function. Previously, we demonstrated that the C. elegans Musashi ortholog, msi-1, regulates forgetting via translational repression of the Arp2/3 actin-branching complex. However, the mechanisms controlling MSI-1 activity during the regulation of forgetting are currently unknown. Here we investigated the effects of protein phosphorylation on MSI-1 activity. We showed that MSI-1 function is likely controlled by alterations of its activity rather than its expression levels. Furthermore, we found that MSI-1 is phosphorylated and using mass spectrometry we identified MSI-1 phosphorylation at three residues (T18, S19 and S34). CRISPR-based manipulations of MSI-1 phosphorylation sites revealed that phosphorylation is necessary for MSI-1 function in both short- and long-term aversive olfactory associative memory. Thus, our study provides insight into the mechanisms regulating memory-related MSI-1 activity and may facilitate the development of novel therapeutic approaches.

Published
2022

42. Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

Author

Heck, Angela, Milnik, Annette, Vukojevic, Vanja, Petrovska, Jana, Egli, Tobias, Singer, Jochen, Escobar, Pablo, Sengstag, Thierry, Coynel, David, Freytag, Virginie, Fastenrath, Matthias, Demougin, Philippe, Loos, Eva, Hartmann, Francina, Schicktanz, Nathalie, Delarue Bizzini, Bernardo, Vogler, Christian, Kolassa, Iris-Tatjana, Wilker, Sarah, Elbert, Thomas, Schwede, Torsten, Beisel, Christian, Beerenwinkel, Niko, de Quervain, Dominique J.-F., and Papassotiropoulos, Andreas

Published
2017
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46. Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect

Author

Grigorenko, Anastasia P., primary, Protasova, Maria S., additional, Lisenkova, Alexandra A., additional, Reshetov, Denis A., additional, Andreeva, Tatiana V., additional, Garcias, Gilberto De Lima, additional, Martino Roth, Maria Da Graça, additional, Papassotiropoulos, Andreas, additional, and Rogaev, Evgeny I., additional

Published
2022
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47. Common Kibra Alleles Are Associated with Human Memory Performance

Author

Papassotiropoulos, Andreas, Stephan, Dietrich A., Huentelman, Matthew J., Hoerndli, Frederic J., Craig, David W., Pearson, John V., Huynh, Kim-Dung, Brunner, Fabienne, Corneveaux, Jason, Osborne, David, Wollmer, M. Axel, Aerni, Amanda, Coluccia, Daniel, Hänggi, Jürgen, Mondadori, Christian R. A., Buchmann, Andreas, Reiman, Eric M., Caselli, Richard J., Henke, Katharina, and de Quervain, Dominique J.-F.

Published
2006
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49. NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis

Author

Singer, Jochen, Ruscheweyh, Hans-Joachim, Hofmann, Ariane L., Thurnherr, Thomas, Singer, Franziska, Toussaint, Nora C., Ng, Charlotte K Y., Piscuoglio, Salvatore, Beisel, Christian, Christofori, Gerhard, Dummer, Reinhard, Hall, Michael N., Krek, Wilhelm, Levesque, Mitchell P., Manz, Markus G., Moch, Holger, Papassotiropoulos, Andreas, Stekhoven, Daniel J., Wild, Peter, Wüst, Thomas, Rinn, Bernd, Beerenwinkel, Niko, and Berger, Bonnie

Abstract

Motivation Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions, but the agreement of results from different facilities is often small. General standards for quality control, reproducibility and documentation are missing. Results We developed NGS-pipe, a flexible, transparent and easy-to-use framework for the design of pipelines to analyze whole-exome, whole-genome and transcriptome sequencing data. NGS-pipe facilitates the harmonization of genomic data analysis by supporting quality control, documentation, reproducibility, parallelization and easy adaptation to other NGS experiments. Availability and implementation https://github.com/cbg-ethz/NGS-pipe

Published
2021

50. Evidence for an association between KIBRA and late-onset Alzheimer's disease

Author

Corneveaux, Jason J., Liang, Winnie S., Reiman, Eric M., Webster, Jennifer A., Myers, Amanda J., Zismann, Victoria L., Joshipura, Keta D., Pearson, John V., Hu-Lince, Diane, Craig, David W., Coon, Keith D., Dunckley, Travis, Bandy, Daniel, Lee, Wendy, Chen, Kewei, Beach, Thomas G., Mastroeni, Diego, Grover, Andrew, Ravid, Rivka, Sando, Sigrid B., Aasly, Jan O., Heun, Reinhard, Jessen, Frank, Kölsch, Heike, Rogers, Joseph, Hutton, Michael L., Melquist, Stacey, Petersen, Ron C., Alexander, Gene E., Caselli, Richard J., Papassotiropoulos, Andreas, Stephan, Dietrich A., and Huentelman, Matthew J.

Published
2010
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