129 results on '"Papalexis P"'
Search Results
2. Percutaneous balloon-assisted ultrasound-guided direct thrombin embolization of superficial femoral artery pseudoaneurysm: a case series and literature review
- Author
-
Bruno, Antonio, Vendetti, Francesco, Papalexis, Nicolas, Russo, Mattia, Papadopoulos, Dimitris, and Mosconi, Cristina
- Published
- 2024
- Full Text
- View/download PDF
3. A novel time-dependent analytical model for optimizing efficiency and valve timing in Ericsson engines
- Author
-
Tzouganakis, Panteleimon, Gakos, Vasilios, Kalligeros, Christos, Papalexis, Christos, and Spitas, Vasilios
- Published
- 2024
- Full Text
- View/download PDF
4. Percutaneous balloon-assisted ultrasound-guided direct thrombin embolization of superficial femoral artery pseudoaneurysm: a case series and literature review
- Author
-
Antonio Bruno, Francesco Vendetti, Nicolas Papalexis, Mattia Russo, Dimitris Papadopoulos, and Cristina Mosconi
- Subjects
Pseudoaneurysm ,Thrombin ,Injection ,Ultrasound ,Balloon ,Superficial femoral artery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Superficial femoral artery (SFA) pseudoaneurysms, a rare but potentially life-threatening complication, that can arise after vascular interventions or trauma. This case series explores the efficacy and safety of a minimally invasive treatment modality, percutaneous ultrasound-guided thrombin injection (PUGTI) combined with balloon occlusion, in three patients with SFA pseudoaneurysms. Case presentation Three patients (age: 71–82 years; 3 female) with SFA pseudoaneurysms underwent PUGTI with balloon occlusion. The procedure involved direct thrombin injection under ultrasound guidance while occluding the parent artery using a balloon catheter. Follow-up was conducted at 1 week and 1 month post-procedure to assess technical success, complications, and recurrence. Conclusion PUGTI combined with balloon occlusion appears to be a safe and effective treatment for SFA pseudoaneurysms, particularly for larger pseudoaneurysms. The procedure is associated with a high technical success rate. Balloon occlusion may offer a safer alternative to direct thrombin injection without occlusion, as it potentially minimizes the risk of complications such as distal thromboembolism.
- Published
- 2024
- Full Text
- View/download PDF
5. Transpedicular Contrast-enhanced CT-guided biopsy of the body and dens of the axis avoiding the trans-oral approach: Technical report and literature review
- Author
-
Nicolas Papalexis, Federico Ponti, Paola Di Masi, Giuliano Peta, Leonor Garbin Savarese, Marco Miceli, Giancarlo Facchini, and Paolo Spinnato
- Subjects
axis ,bone neoplasm ,cervical vertebra ,image-guided biopsy ,radiology ,interventional ,spiral computed ,tomography ,cancer metastasis ,sarcoma ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
This technical report illustrates the technique to perform computed tomography (CT)-guided bone biopsies in the body and dens of the axis (C2 vertebra) through a posterior transpedicular approach with the use of preoperative contrast-enhanced scans to highlight the course of the vertebral artery. The technique is presented through two exemplification cases: a pediatric patient with osteoblastoma and secondary aneurysmal bone cyst and one adult patient with melanoma metastasis. This case highlights the potential of the CT-guided posterolateral/transpedicular approach for performing safe and effective biopsies in the body and dens of C2, even in pediatric patients.
- Published
- 2024
- Full Text
- View/download PDF
6. Formulation of a non-dimensional criterion for stable dynamical response in coaxial magnetic gears
- Author
-
Tzouganakis, Panteleimon, Gakos, Vasilios, Kalligeros, Christos, Papalexis, Christos, Tsolakis, Antonios, and Spitas, Vasilios
- Published
- 2024
- Full Text
- View/download PDF
7. Imaging Features of Alveolar Soft Part Sarcoma: Single Institution Experience and Literature Review
- Author
-
Paolo Spinnato, Nicolas Papalexis, Marco Colangeli, Marco Miceli, Amandine Crombé, Anna Parmeggiani, Emanuela Palmerini, Alberto Righi, and Giuseppe Bianchi
- Subjects
magnetic resonance imaging ,ultrasonography ,multidetector computed tomography ,soft tissue sarcomas ,diagnosis ,prognosis ,Medicine (General) ,R5-920 - Abstract
Alveolar soft part sarcoma (ASPS) is an extremely rare and aggressive soft-tissue sarcoma (STS) subtype with poor prognosis and limited response to radiation therapy and chemotherapy. Prompt recognition and referral to sarcoma centers for appropriate management are crucial for patients’ survival. The purpose of this study was to report ASPS pre-treatment imaging features and to examine the existing literature on this topic. Twelve patients (7 women, 5 men—mean age 27.1 ± 10.7 years) were included from our single-center experience. Ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) available were reviewed according to an analysis grid incorporating features from the latest research on STS. Clinical, histological, and outcome data were collected. MRI was available in 10 patients (83.3%), US in 7 patients (58.3%), and CT in 3 patients (25%). Mean longest tumor diameter was 7.6 ± 2.9 cm, and all tumors were deeply seated. Large peritumoral feeding vessels were systematically found and identified on ultrasonography (7/7), MRI (10/10), and CT (3/3). US revealed a well-defined heterogeneous hypoechoic pattern, with abundant flow signals in all patients (7/7). In all patients, MRI showed mildly high signal intensity (SI) on T1-WI and high SI on T2-WI and peritumoral edema. Moreover, flow-voids (due to arteriosus high-flow) into the peritumoral/intratumoral feeding vessels were detected in the MRI fluid-sensitive sequences of all patients. At baseline, whole-body contrast-enhanced CT revealed metastases in 8/12 (66.7%) patients. A pre-treatment longest diameter > 5 cm was significantly associated with distant metastases at diagnosis (p = 0.01). A maximum diameter > 5 cm represents a risk of metastatic disease at diagnosis (odds ratio = 45.0000 (95% CI: 1.4908—1358.3585), p = 0.0285). In the comprehensive literature review, we found 14 articles (case series or original research) focusing on ASPS imaging, with a total of 151 patients included. Merging our experience with the data from the existing literature, we conclude that the hallmark of ASPS imaging at presentation are the following characteristics: deep location, a slight hyperintense MRI SI on T1-WI and a hyperintense SI on T2-WI, numerous MRI flow voids, high internal vascularization, and large peritumoral feeding vessels.
- Published
- 2023
- Full Text
- View/download PDF
8. Palliative Arterial Embolization for Metastases of the Sternum
- Author
-
Papalexis, Nicolas, Peta, Giuliano, Vara, Giulio, Spinnato, Paolo, Errani, Costantino, Martella, Claudia, Miceli, Marco, and Facchini, Giancarlo
- Published
- 2023
- Full Text
- View/download PDF
9. The New Ice Age of Musculoskeletal Intervention: Role of Percutaneous Cryoablation in Bone and Soft Tissue Tumors
- Author
-
Nicolas Papalexis, Leonor Garbin Savarese, Giuliano Peta, Costantino Errani, Gianmarco Tuzzato, Paolo Spinnato, Federico Ponti, Marco Miceli, and Giancarlo Facchini
- Subjects
interventional radiology ,metastatic neoplasms ,orthopedic surgery ,palliative medicine ,cryoablation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In the rapidly evolving field of interventional oncology, minimally invasive methods, including CT-guided cryoablation, play an increasingly important role in tumor treatment, notably in bone and soft tissue cancers. Cryoablation works using compressed gas-filled probes to freeze tumor cells to temperatures below −20 °C, exploiting the Joule–Thompson effect. This cooling causes cell destruction by forming intracellular ice crystals and disrupting blood flow through endothelial cell damage, leading to local ischemia and devascularization. Coupling this with CT technology enables precise tumor targeting, preserving healthy surrounding tissues and decreasing postoperative complications. This review reports the most important literature on CT-guided cryoablation’s application in musculoskeletal oncology, including sarcoma, bone metastases, and bone and soft tissue benign primary tumors, reporting on the success rate, recurrence rate, complications, and technical aspects to maximize success for cryoablation in the musculoskeletal system.
- Published
- 2023
- Full Text
- View/download PDF
10. Detailed Investigation of the Eddy Current and Core Losses in Coaxial Magnetic Gears through a Two-Dimensional Analytical Model
- Author
-
Nikolina Nikolarea, Panteleimon Tzouganakis, Vasilios Gakos, Christos Papalexis, Antonios Tsolakis, and Vasilios Spitas
- Subjects
coaxial magnetic gear ,eddy current losses ,core losses ,power losses ,analytical model ,Applied mathematics. Quantitative methods ,T57-57.97 ,Mathematics ,QA1-939 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
This work introduces a 2D model that calculates power losses in coaxial magnetic gears (CMGs). The eddy current losses of the magnets are computed analytically, whereas the core losses of the ferromagnetic segments are computed using an analytical–finite element hybrid model. The results were within 1.51% and 3.18% of those obtained from an FEA for the eddy current and core losses in the CMG for an indicative inner rotor speed of 2500 rpm. In addition, the significance of the circumferential magnet segmentation is demonstrated in the CMGs. Furthermore, a parametric investigation of the efficiency of the system for different applied external loads is carried out. Finally, a mesh sensitivity analysis is performed, along with the computation of the average power losses throughout one full period, resulting in an at least 80% reduction in computational costs with a negligible effect on accuracy. The developed model could be a valuable tool for the minimization of power losses in CMGs since it combines high accuracy with a low computational cost.
- Published
- 2024
- Full Text
- View/download PDF
11. Torque Calculation and Dynamical Response in Halbach Array Coaxial Magnetic Gears through a Novel Analytical 2D Model
- Author
-
Panteleimon Tzouganakis, Vasilios Gakos, Christos Kalligeros, Christos Papalexis, Antonios Tsolakis, and Vasilios Spitas
- Subjects
coaxial magnetic gear ,Halbach array ,analytical torque calculation ,dynamical response ,slip effect ,torque ripple ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Coaxial magnetic gears have piqued the interest of researchers due to their numerous benefits over mechanical gears. These include reduced noise and vibration, enhanced efficiency, lower maintenance costs, and improved backdrivability. However, their adoption in industry has been limited by drawbacks like lower torque density and slippage at high torque levels. This work presents an analytical 2D model to compute the magnetic potential in Halbach array coaxial magnetic gears for every rotational angle, geometry configuration, and magnet specifications. This model calculates the induced torques and torque ripple in both rotors using the Maxwell Stress Tensor. The results were confirmed through Finite Element Analysis (FEA). Unlike FEA, this analytical model directly produces harmonics values, leading to faster computational times as it avoids torque calculations at each time step. In a case study, a standard coaxial magnetic gear was compared to one with a Halbach array, revealing a 14.3% improvement in torque density and a minor reduction in harmonics that cause torque ripple. Additionally, a case study was conducted to examine slippage in both standard and Halbach array gears during transient operations. The Halbach array coaxial magnetic gear demonstrated a 13.5% lower transmission error than its standard counterpart.
- Published
- 2024
- Full Text
- View/download PDF
12. Current concepts in the diagnosis and treatment of adhesive capsulitis: role of diagnostic imaging and ultrasound-guided interventional procedures
- Author
-
Papalexis, Nicolas, Parmeggiani, Anna, Facchini, Giancarlo, Miceli, Marco, Carbone, Giuseppe, Cavallo, Marco, and Spinnato, Paolo
- Published
- 2022
- Full Text
- View/download PDF
13. Minimally Invasive Interventional Procedures for Metastatic Bone Disease: A Comprehensive Review
- Author
-
Nicolas Papalexis, Anna Parmeggiani, Giuliano Peta, Paolo Spinnato, Marco Miceli, and Giancarlo Facchini
- Subjects
bone metastases ,imaging ,interventional radiology ,ablation techniques ,embolization ,high-intensity focused ultrasound ablation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Metastases are the main type of malignancy involving bone, which is the third most frequent site of metastatic carcinoma, after lung and liver. Skeletal-related events such as intractable pain, spinal cord compression, and pathologic fractures pose a serious burden on patients’ quality of life. For this reason, mini-invasive treatments for the management of bone metastases were developed with the goal of pain relief and functional status improvement. These techniques include embolization, thermal ablation, electrochemotherapy, cementoplasty, and MRI-guided high-intensity focused ultrasound. In order to achieve durable pain palliation and disease control, mini-invasive procedures are combined with chemotherapy, radiation therapy, surgery, or analgesics. The purpose of this review is to summarize the recently published literature regarding interventional radiology procedures in the treatment of cancer patients with bone metastases, focusing on the efficacy, complications, local disease control and recurrence rate.
- Published
- 2022
- Full Text
- View/download PDF
14. Association between smoking cessation and alterations in forced expiratory volume in one second (FEV1). A Follow-Up Study from a Greek Tobacco Cessation Clinic
- Author
-
Nikolaos Trakas, Vasiliki Epameinondas Georgakopoulou, Despoina Melemeni, Christos Damaskos, Konstantinos Mantzouranis, Nikolaos Garmpis, Aikaterini Gkoufa, Petros Papalexis, Serafeim Chlapoutakis, Pagona Sklapani, Dimitrios Mermigkis, Agathi Lekkakou, and Xanthi Tsiafaki
- Subjects
forced expiratory volume ,smoking cessation ,tobacco smoking ,spirometry ,Medicine ,Psychiatry ,RC435-571 - Abstract
Background: Cigarette smoking is the most important preventable cause of several diseases such as malignancies, pulmonary and cardiovascular diseases. Smoking cessation is now supported by both behavioral counseling and medical pharmacotherapy and is the only effective approach for slowing down an accelerated decline in forced expiratory volume in one second (FEV1). Our study aims to examine changes in forced expiratory volume in one second (FEV1) after smoking cessation for smokers attending our smoking cessation clinic their correlation to smokers’ demographic characteristics.Methods: 114 smokers (48 males and 66 females), with a mean age of 48.36±10.49 years, were enrolled. They were classified in 4 groups, according to their age; 60 years (Group D) and underwent Spirometry on the 1st day of visit, one month (2nd visit) and, 3 months later (3rd visit).Findings: Statistically significant increase in FEV1 values at the 2nd and 3rd visit compared to the 1st visit was observed in smokers who quit smoking in Group Α, B and C (p
- Published
- 2022
- Full Text
- View/download PDF
15. Proof of Concept of a Novel Solid–Solid Heat Exchanger Based on a Double L-Valve Concept
- Author
-
Christos Papalexis, Dionisis Stefanitsis, Myrto Zeneli, Nikolaos Nikolopoulos, and Panteleimon Tzouganakis
- Subjects
solid–solid heat exchanger ,Carbonate Looping ,Double L-Valve ,Finite Element Analysis (FEA) ,one-dimensional thermal model ,scale-up model ,Technology - Abstract
A proof of concept of a novel parallel-flow solid–solid heat exchanger consisting of two L-Valves with concentric vertical tubes, named as Double L-Valve, is presented for the case of the Carbonate Looping process, as a CO2 capture technology. The operational objective of the solid–solid heat exchanger is to heat up the relatively cold solid stream coming from the carbonator reactor by absorbing heat from the hotter stream coming from the calciner. This novel solid–solid heat exchanger concept has been constructed on a small scale to study the hydrodynamic response of the system experimentally at different designs and airflow rates in its cold state. Based on the experimental data from the small prototype, a scaled-up hydrodynamic model is proposed that provides estimations for the operational requirements at an industrial scale. Apart from the cold flow pilot model, the heat exchanger is being assessed in the current work for an industrial case study in terms of the following: (a) the heat transfer via rigorous one-dimensional thermal modelling, (b) the structural integrity of the design through Finite Element Method (FEM) analysis, and (c) a parametric study for its expected cost. The purpose of this work is to provide a holistic approach of this novel solid–solid heat exchanger concept, the main advantage of which is its simple design and relatively low cost.
- Published
- 2023
- Full Text
- View/download PDF
16. Ultrasound-Guided Percutaneous Bone Biopsy: Feasibility, Diagnostic Yield and Technical Notes
- Author
-
Federico Ponti, Alessio Arioli, Chiara Longo, Marco Miceli, Marco Colangeli, Nicolas Papalexis, and Paolo Spinnato
- Subjects
bone neoplasms ,image-guided biopsy ,radiology ,interventional ,ultrasonography ,Medicine (General) ,R5-920 - Abstract
While nowadays, CT-guided bone biopsy represents the gold standard tool for histopathological and microbiological diagnosis of skeletal lesions, the role of US-guided bone biopsy has not yet been fully explored. US-guided biopsy offers several advantages, such as the absence of ionizing radiation, fast acquisition time, as well as good intra-lesional echo, and structural and vascular characterization. Despite that, a consensus in regard to its applications in bone neoplasms has not been established. Indeed CT-guided technique (or fluoroscopic ones) still represents the standard choice in clinical practice. This review article aims to review the literature data about US-guided bone biopsy, underlying clinical-radiological indications, advantages of the procedure and future perspectives. Bone lesions taking the best advantages of the US-guided biopsy are osteolytic, determining the erosion of the overlying bone cortex and/or with an extraosseous soft-tissue component. Indeed, osteolytic lesions with extra-skeletal soft-tissue involvement represent a clear indication for US-guided biopsy. Moreover, even lytic bone lesions with cortical thinning and/or cortical disruption, especially located in the extremities or pelvis, can be safely sampled with US guidance with very good diagnostic yield. US-guided bone biopsy is proven to be fast, effective and safe. Additionally, it offers real-time needle evaluation, an advantage when compared to CT-guided bone biopsy. In the current clinical settings, it seems relevant to select the exact eligibility criteria for this imaging guidance since the effectiveness can vary depending on the type of lesion and body site involved.
- Published
- 2023
- Full Text
- View/download PDF
17. Exploring the Role of ACE2 as a Connecting Link between COVID-19 and Parkinson’s Disease
- Author
-
Efthalia Angelopoulou, Eleni Karlafti, Vasiliki E. Georgakopoulou, Petros Papalexis, Sokratis G. Papageorgiou, Thomas Tegos, and Christos Savopoulos
- Subjects
neurodegeneration ,dopaminergic degeneration ,neuroinflammation ,COVID-19 pandemic ,Science - Abstract
Coronavirus disease 2019 (COVID-19) is frequently accompanied by neurological manifestations such as headache, delirium, and epileptic seizures, whereas ageusia and anosmia may appear before respiratory symptoms. Among the various neurological COVID-19-related comorbidities, Parkinson’s disease (PD) has gained increasing attention. Some cases of PD disease have been linked to COVID-19, and both motor and non-motor symptoms in Parkinson’s disease patients frequently worsen following SARS-CoV-2 infection. Although it is still unclear whether PD increases the susceptibility to SARS-CoV-2 infection or whether COVID-19 increases the risk of or unmasks future cases of PD, emerging evidence sheds more light on the molecular mechanisms underlying the relationship between these two diseases. Among them, angiotensin-converting enzyme 2 (ACE2), a significant component of the renin-angiotensin system (RAS), seems to play a pivotal role. ACE2 is required for the entry of SARS-CoV-2 to the human host cells, and ACE2 dysregulation is implicated in the severity of COVID-19-related acute respiratory distress syndrome (ARDS). ACE2 imbalance is implicated in core shared pathophysiological mechanisms between PD and COVID-19, including aberrant inflammatory responses, oxidative stress, mitochondrial dysfunction, and immune dysregulation. ACE2 may also be implicated in alpha-synuclein-induced dopaminergic degeneration, gut–brain axis dysregulation, blood–brain axis disruption, autonomic dysfunction, depression, anxiety, and hyposmia, which are key features of PD.
- Published
- 2023
- Full Text
- View/download PDF
18. Improving the wear resistance of 3D printed spur gears through a free-form tooth flank optimization process
- Author
-
Kalligeros Christos, Papalexis Christos, Georgiou Dimitrios, Krifos Dimitrios, Vakouftsis Christos, Terpos Klearchos, Goudas Konstantinos, Balis Panagiotis, Kontaris Theodoros, Kaisarlis Georgios, Tsolakis Antonios, Zalimidis Pavlos, Sapidis Nickolas, Provatidis Christopher G., and Spitas Vasilios
- Subjects
Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Involute gears have traditionally been the preferred choice for gear transmission systems due to their simplicity and interchangeability. However, there are applications where they do not provide the most durable and efficient solution. While the cost of implementing optimized non-involute gears in most applications often outweighs their comparative advantages, the advent of additive manufacturing has opened up possibilities for designers to explore alternative gear tooth profiles. This is particularly relevant in the realm of plastic gears, where optimized non-involute gears produced through 3D printing can address their primary drawbacks, such as surface durability and wear resistance. In this study, a comprehensive free-form optimization process was conducted to determine the optimal tooth profile that minimizes wear on 3D printed spur gears during operation. The tooth flank geometry was represented using a 4th order B-spline curve, and a genetic algorithm was employed to determine the optimum positions of the control points aiming to minimize wear depth across the tooth flanks. The spur gears were manufactured using Fused Deposition Modeling (FDM) with PLA material. The parameters of the additive manufacturing process were experimentally fine-tuned to achieve the best possible accuracy. To evaluate the performance of the optimized free-form gears, two case studies were implemented, demonstrating that the optimized gears achieved a remarkable reduction of average wear depth by more than 50% and a reduction of maximum wear depth by more than 69% compared to standard involute gears. To further validate the effectiveness of the optimization method, experiments were carried out using an FZG test rig. The profiles of the tooth flanks were measured on a Coordinate Measuring Machine (CMM) before and after the experiments to compare the wear depth against the standard involute gears. The results revealed a significant improvement in the wear resistance of the tooth flanks, with a reduction of wear depth of 44.1%.
- Published
- 2023
- Full Text
- View/download PDF
19. Knowledge and Attitudes of Healthcare Professionals Regarding Perinatal Influenza Vaccination during the COVID-19 Pandemic
- Author
-
Chrysoula Taskou, Antigoni Sarantaki, Apostolos Beloukas, Vasiliki Ε. Georgakopoulou, Georgios Daskalakis, Petros Papalexis, and Aikaterini Lykeridou
- Subjects
healthcare professionals ,knowledge ,attitudes ,influenza vaccination ,pregnancy ,Medicine - Abstract
Immunizations during pregnancy are an important aspect of perinatal care. Although the influenza vaccine during pregnancy is safe, vaccination rates are low. According to research data, one of the reasons for the low vaccination rates among pregnant women is that they do not receive a clear recommendation from healthcare providers. This study aims to record the knowledge and attitudes about influenza vaccination and investigate healthcare professionals’ recommendations during the perinatal period. A cross-sectional study was conducted with convenience sampling in Athens, Greece. Our purposive sample included 240 midwives, Ob/Gs, and pediatricians. Data were collected using an appropriate standardized questionnaire with information about demographics, attitudes towards influenza vaccination, and knowledge about the influenza virus and peripartum vaccination. Statistical analysis was conducted using IBM SPSS-Statistics version 26.0. This study identifies the reasons for the lack of vaccine uptake including a wide range of misconceptions or lack of knowledge about influenza infection, lack of convenient access to get vaccinated, etc. Misconceptions about influenza and influenza vaccines could be improved by better education of healthcare workers. Continuing professional education for health professionals is necessary to improve the level of knowledge, prevent negative beliefs, and promote preventive and therapeutic practices.
- Published
- 2023
- Full Text
- View/download PDF
20. Drug-Induced Liver Injury in Hospitalized Patients during SARS-CoV-2 Infection
- Author
-
Eleni Karlafti, Daniel Paramythiotis, Konstantina Pantazi, Vasiliki Epameinondas Georgakopoulou, Georgia Kaiafa, Petros Papalexis, Adonis A. Protopapas, Eleftheria Ztriva, Varvara Fyntanidou, and Christos Savopoulos
- Subjects
drug-induced liver injury (DILI) ,COVID-19 ,liver injury ,liver dysfunction ,COVID-19 treatment ,liver function ,Medicine (General) ,R5-920 - Abstract
In the last few years, the world has had to face the SARS-CoV-2 infection and its multiple effects. Even though COVID-19 was first considered to be a respiratory disease, it has an extended clinical spectrum with symptoms occurring in many tissues, and it is now identified as a systematic disease. Therefore, various drugs are used during the therapy of hospitalized COVID-19 patients. Studies have shown that many of these drugs could have adverse side-effects, including drug-induced liver injury—also known as DILI—which is the focus of our review. Despite the consistent findings, the pathophysiological mechanism behind DILI in COVID-19 disease is still complex, and there are a few risk factors related to it. However, when it comes to the diagnosis, there are specific algorithms (including the RUCAM algorithm) and biomarkers that can assist in identifying DILI and which we will analyze in our review. As indicated by the title, a variety of drugs are associated with this COVID-19-related complication, including systemic corticosteroids, drugs used for the therapy of uncontrolled cytokine storm, as well as antiviral, anti-inflammatory, and anticoagulant drugs. Bearing in mind that hepatotoxicity is very likely to occur during COVID-19, especially in patients treated with multiple medications, we will also refer to the use of other drugs used for DILI therapy in an effort to control and prevent a severe and long-term outcome.
- Published
- 2022
- Full Text
- View/download PDF
21. CT-Guided Radiofrequency Thermal Ablation for the Treatment of Atypical, Early-Onset Osteoid Osteoma in Children Younger than 4 Years Old: Single-Institution Experience and Literature Review
- Author
-
Nicolas Papalexis, Giuliano Peta, Federico Ponti, Gianmarco Tuzzato, Marco Colangeli, Giancarlo Facchini, and Paolo Spinnato
- Subjects
bone neoplasms ,ablation techniques ,interventional radiology ,osteoid osteoma ,pediatrics ,image-guided biopsy ,Medicine (General) ,R5-920 - Abstract
The aim of our study is to report our experience on CT-guided radiofrequency ablation (RFA) for osteoid osteoma (OO) in children under 4 years of age and to review the literature regarding this atypical, early onset of the disease. We retrospectively reviewed the clinical and radiological records of the patients treated with CT-guided RFA for OO at our institution (2006–2021), including those under 4 years of age. Data regarding technical success, clinical success, and biopsy diagnostic yield were collected. Moreover, we performed a literature review including previous articles on early-onset OO. We found only 12 patients that were under 4 years of age (12/842–1.4%) at the time of RFA treatment: 4 F and 8 M, mean age at the time of the treatment 35.3 months (range 22–46 months). The mean follow-up was 22.8 months (range 6–96 months). Technical success was achieved in all cases (12/12). In all patients (12/12), a complete remission of the pain symptoms was achieved at clinical follow-up controls. No recurrence of pain or complications were documented. The histopathological diagnosis was confirmed in 4 patients (4/12–33.3%). Moreover, we found another 9 articles in the literature with a main focus on early-onset OO (
- Published
- 2022
- Full Text
- View/download PDF
22. A Coder-Decoder model for use in Lossless Data Compression
- Author
-
Papalexis, Alex
- Subjects
Computer Science - Information Theory - Abstract
This article describes a technique of using a trigonometric function and combinatorial calculations to code or transform any finite sequence of binary numbers (0s and 1s) of any length to a unique set of three Real numbers. In reverse, these three Real numbers can be used independently to reconstruct the original Binary sequence precisely. The main principles of this technique are then applied in a proposal for a highly efficient model for Lossless Data Compression., Comment: 7 pages, 1 figure, 2 tables
- Published
- 2010
23. A Rare Case of Multiple Gastrointestinal Stromal Tumors Coexisting with a Rectal Adenocarcinoma in a Patient with Attenuated Familial Adenomatous Polyposis Syndrome and a Mini Review of the Literature
- Author
-
Daniel Paramythiotis, Filippos Kyriakidis, Eleni Karlafti, Triantafyllia Koletsa, Anastasia Tsakona, Petros Papalexis, Aristeidis Ioannidis, Petra Malliou, Smaro Netta, and Antonios Michalopoulos
- Subjects
multiple GIST ,AFAP ,rectal ,adenocarcinoma ,surgery ,case report ,Medicine (General) ,R5-920 - Abstract
Background: Multiple gastrointestinal stromal tumors (GISTs) are extremely rare entities that exist either as spontaneous GISTs or as part of various syndromes, such as Carney’s triad and type I neurofibromatosis (NF1). Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis (FAP) with a milder clinical presentation. Both GISTs and AFAP have been reported to coexist with colorectal cancer, but the coexistence of GISTs and AFAP has never been reported in the literature before. Case report: A 45-year-old male patient with known AFAP arrived scheduled for a total colectomy and ileo-rectal anastomosis due to the malignancy of one of the previously biopsied polyps of the upper rectum. Intraoperatively, multiple nodular tumors were found at the jejunum within a length of 45 cm, for which an enterectomy and enteroanastomosis were performed. A histopathological examination of the whole colectomy specimen confirmed the presence of multiple polyps in the large intestine along with a rectal invasive adenocarcinoma. At the same time, in the examined part of the small intestine, 15 GISTs sized from 0.5 to 2.0 cm of prognostic group I, were identified. The patient’s postoperative course was uncomplicated. Conclusion: Multiple GISTs may present as an asymptomatic disease, and the same thing is true for colorectal cancer. Therefore, the appropriate screening is crucial for entities such as AFAP, since the surgery was performed because of the malignant transformation in one of the polyps and revealed multiple GISTs, as well.
- Published
- 2022
- Full Text
- View/download PDF
24. Torque ripple investigation in coaxial magnetic gears
- Author
-
Tzouganakis Panteleimon, Gakos Vasilios, Kalligeros Christos, Papalexis Christos, Tsolakis Antonios, and Spitas Vasilios
- Subjects
coaxial magnetic gear ,torque ripples ,analytical model ,maxwell stress tensor ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Magnetic gears offer significant advantages such as low noise and vibration level, lower maintenance and higher reliability compared to mechanical gears and are suitable for many applications in the industry. The coaxial magnetic gear has been extensively discussed in the literature, since it achieves higher torque densities amongst other magnetic gear configurations. The magnetic field is generated by permanent magnets mounted on the two rotors and a modulator between them. The modulator consists of ferromagnetic segments that are typically encased in a resin in order to increase its stiffness without compromising the generated magnetic field. However, due to the development of radial forces, oscillations of the ferromagnetic segments occur, which lead to torque ripples that affect the operation of the coaxial magnetic gear drive in applications where accuracy is required. This work introduces a computationally lightweight analytical 2D model in order to determine the applied radial force on the ferromagnetic segments at each angle of rotation of the two rotors and henceforth calculate the displacement of these segments using FEA. In this way it is possible to assess the variation of the torque (ripple) versus the angle of rotation of the input or output shaft. A parametric investigation examining the influence of the ferromagnetic segment thickness on the resulting torque ripple of a specific drive was carried out illustrating the benefits of the analytical models developed herein.
- Published
- 2022
- Full Text
- View/download PDF
25. Development of a free-form tooth flank optimization method to improve pitting resistance of spur gears
- Author
-
Kalligeros Christos, Koronaios Panagiotis, Tzouganakis Panteleimon, Papalexis Christos, Tsolakis Antonios, and Spitas Vasilios
- Subjects
Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Although steel involute gears are the standard solution for gear transmissions, they tend to suffer from poor pitting resistance. Pitting typically occurs when the gear tooth flanks have high equivalent curvature at the contact point and/or when the equivalent curvature is not constant across the contact path leading to high contact pressures and the development of surface fatigue. In this paper a new optimization method is presented to produce spur gear tooth flanks with improved pitting performance compared to involute ones. The tooth flanks are represented as B-spline curves, the control points of which are the variables for the optimization problem. The constraints were designed to ensure that all the examined profiles satisfy the law of gearing and do not contain any cusps or C1 discontinuities. Deterministic and stochastic algorithms were implemented and both closed and open path of contact gear sets were examined to determine the optimum tooth profile. The optimization results show that the maximum equivalent curvature of the optimum profiles is reduced by 83% compared to the corresponding standard profiles, while the deviation from the mean value is reduced by 98%. Both the standard and the optimized gears where examined comparatively also through finite element analysis. For the case selected the maximum contact pressure developed on the optimized gear set was 77% of the respective maximum contact pressure on the standard gear set whereas the corresponding deviation from the mean value was 5%. At the same time, the bending stresses developed in the optimized gear are slightly lower than those in the standard one.
- Published
- 2022
- Full Text
- View/download PDF
26. Prognostic factors for anti-angiogenic treatment in patients with metastatic colorectal cancer: New insights for an old issue from a single institution experience.
- Author
-
Lai, Eleonora, Ziranu, Pina, Mariani, Stefano, Loi, Francesco, Palmas, Enrico, D'Agata, Alessandra Pia, Dell'Utri, Veronica, Deias, Giulia, Balconi, Francesca, Rizzo, Daiana, Papalexis, Giulia, Codipietro, Claudia, Sanna, Giorgia, Moledda, Giusy, Donisi, Clelia, Spanu, Dario, Pretta, Andrea, Pusceddu, Valeria, Puzzoni, Marco, and Scartozzi, Mario
- Published
- 2024
- Full Text
- View/download PDF
27. Comparative analysis of the ISO tolerance class of 3D-printed spur cylindrical gears produced with material extrusion and powder bed fusion techniques
- Author
-
Vakouftsis, Christos, Vasileiou, Georgios, Kaisarlis, Georgios, Kalligeros, Christos, Papalexis, Christos, Zalimidis, Pavlos, Provatidis, Christopher, and Spitas, Vasileios
- Abstract
The present work correlates the printing accuracy of two major 3D-printing techniques applied for the production of spur gears by calculating the ISO tolerance class that defines the accuracy level of gears in all industrial applications. Specimens were produced using material extrusion MEX-TRB/P/ABS and powder bed fusion PBF-LB/P/PA22 techniques, evaluated by using a touch-probe coordinate measuring machine (CMM) with appropriate software and finally compared in terms of standards gear geometry errors and deviations. MEX-TRB produced specimens exhibited higher levels of accuracy and ISO quality class correspondingly. Both sets of specimens were found to comply with ISO Q12 or higher that greatly varies from the quality class of most metallic gears used in industrial applications. The printing parameters are detailed and discussed extensively in an attempt to provide insight on further research and process optimisation for the production of AM gears.
- Published
- 2024
- Full Text
- View/download PDF
28. Preoperative Arterial Embolization for Heterotopic Ossification of the Hip.
- Author
-
Papalexis, Nicolas, Peta, Giuliano, Errani, Costantino, Miceli, Marco, and Facchini, Giancarlo
- Abstract
To investigate the efficacy and safety of preoperative arterial embolization for neurogenic heterotopic ossification (NHO) of the hip. This single-center retrospective study reviewed outcomes in 16 consecutive patients who had surgical resection of NHO of the hip: 8 of whom underwent preoperative arterial embolization and 8 of whom did not. Both patient cohorts had similar baseline characteristics. A mean of 2.62 ± 1.9 arteries per patient, including the gluteal, lateral circumflex femoral, and deep circumflex iliac branches, were embolized using an n -butyl cyanoacrylate (NBCA)–ethiodized oil mixture. Data from both cohorts regarding intraoperative blood loss, volume of blood transfused, complications, and duration of hospitalization were compared. A mean of 2.6 ± 1.9 arteries were embolized with NBCA–ethiodized oil, mainly the gluteal arteries, lateral circumflex femoral artery, and deep circumflex iliac artery. In the embolization group, mean intraoperative blood loss was 875 mL ± 320, mean number of units of blood used was 0.5 ± 0.7, and mean number of days of hospitalization was 6.4 days ± 1.6. In the control group, mean intraoperative blood loss was 1,350 mL ± 120, mean number of units of blood used was 2 ± 1.1, and average number of days of hospitalization was 11.5 days ± 1.4. The embolization group had a mean reduction in blood loss of 40.7% (P = 0.035), reduction in units of blood administered of 75% (P = 0.021), and reduction in days of hospitalization of 44.7% (P = 0.014). No procedural complications were recorded. Preoperative arterial embolization is effective and safe in reducing intraoperative blood loss, number of hospitalization days, and need for blood transfusions in surgical resection of NHO of the hip. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
29. Immature granulocytes: Innovative biomarker for SARS‑CoV‑2 infection
- Author
-
Georgakopoulou, V.E. Makrodimitri, S. Triantafyllou, M. Samara, S. Voutsinas, P.M. Anastasopoulou, A. Papageorgiou, C.V. Spandidos, D.A. Gkoufa, A. Papalexis, P. Xenou, E. Chelidonis, G. Sklapani, P. Trakas, N. Sipsas, N.V.
- Abstract
Immature granulocytes (IGs) include metamyelocytes, myelocytes and promyelocytes, and are the precursors of neutrophils. Increased IG counts found in peripheral blood indicate an enhanced bone marrow activity. In addition, IGs have been evaluated in numerous clinical conditions, such as severe acute pancreatitis, systemic inflammatory response syndrome and infectious complications following open‑heart surgery under cardiopulmonary bypass. Neutrophils are considered to play a crucial role in the host defense during bacterial and fungal infections, and are involved in the antiviral immune response. Numerous studies have reported the role of neutrophils in coronavirus disease 2019 (COVID‑19) infection, concluding that the percentage of neutrophils may be a predictor of the severity of COVID‑19 infection. There has been limited research regarding the role of neutrophil precursors in viral infections, including severe acute respiratory syndrome coronavirus 2 infection. The present thus aimed to evaluate the role of the IG count in patients hospitalized due to COVID‑19 infection. The patients were predominantly infected with the alpha variant and were all unvaccinated. The IG count was measured and was found to be associated with disease severity, with patient outcomes, with the duration of hospitalization and with the development of complications. The IG count was a significantly associated with the severity of COVID‑19 infection, with greater IG count values being detected in severe and critical cases. In addition, greater IG count values were associated with a longer duration of hospitalization. Furthermore, the IG count was found to be an independent prognostic biomarker of intubation and mortality in patients with COVID‑19, according to multivariate logistic regression analysis, including age, the male sex and the presence of comorbidities as confounders.
- Published
- 2022
30. Foodborne botulism: A brief review of cases transmitted by cheese products (Review)
- Author
-
Chaidoutis, E. Keramydas, D. Papalexis, P. Migdanis, A. Migdanis, I. Lazaris, A.C. Kavantzas, N.
- Abstract
Food safety constitutes a basic priority for public health. Foodborne botulism occurs worldwide; it is an acute paralytic disease caused by the consumption of food containing the botulinum toxin. Growing consumer demand for cheese products could result in increased exposure of the population to this toxin, and thus the risk of foodborne botulism. The majority of cases of botulism caused by dairy products are related to cheese products specifically. Epidemic outbreaks and isolated cases have been reported over time. Domestically canned foods are still among the primary causes of the disease. Cheese products are not regularly involved in botulism incidents; it is however, necessary to take control measures for manufacturing and domestic preparation due to the high risk of occurrence of this particular disease. The aim of this review is to discuss foodborne botulism caused by cheese products, providing a brief epidemiological history, and to examine certain control measures that should be taken throughout the production process to better protect public health. © 2022, Spandidos Publications. All rights reserved.
- Published
- 2022
31. Targeting the Endocannabinoid System: From the Need for New Therapies to the Development of a Promising Strategy. What About Pancreatic Cancer?
- Author
-
Garmpis, N. Damaskos, C. Dimitroulis, D. Garmpi, A. Diamantis, E. Sarantis, P. Georgakopoulou, V.E. Patsouras, A. Prevezanos, D. Syllaios, A. Kyriakos, G. Koustas, E. Despotidis, M. Vallilas, C. Papalexis, P. Antoniou, E.A. Kontzoglou, K. Kouraklis, G.
- Subjects
digestive, oral, and skin physiology ,lipids (amino acids, peptides, and proteins) - Abstract
Pancreatic cancer is one of the most fatal malignancies, and therefore, new strategies, which aim at the improvement of the prognosis of this lethal disease, are needed. Many clinical trials have failed to improve overall survival. Nowadays, research is focused on advances provided by novel potential targets to efficiently enhance life expectancy. Cannabinoids, the active components of Cannabis sativa L., and their derivatives, have been reported as palliative adjuvants to conventional chemotherapeutic regimens. Cannabinoid effects are known to be mediated through the activation of cannabinoid receptors. To date, two cannabinoid receptors, cannabinoid receptor 1 and 2, have been cloned and identified from mammalian tissues. Cannabinoids exert a remarkable antitumoral effect on pancreatic cancer cells, due to their ability to selectively induce apoptosis of these cells. This review strengthens the perception that cannabinoid receptors might be useful in clinical testing to prognose and treat pancreatic cancer. Many studies have tried to describe the mechanism of cell death induced by cannabinoids. The aim of this review is to discuss the effects of cannabinoid receptors in pancreatic cancer in order to provide a brief insight into cannabinoids and their receptors as pancreatic cancer biomarkers and in therapeutic strategies. Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
- Published
- 2022
32. Food hygiene requirements in health care enterprises in Greece The role of the hospital sanitarian.
- Author
-
Chaidoutis, E., Keramydas, D., Papalexis, P., Koutou, A., Koutsiari, F., Doufexi, M., and Karagianni, V.
- Subjects
HYGIENE ,MEDICAL care ,FOOD safety ,PUBLIC hospitals ,OCCUPATIONAL roles ,SEXUAL health - Abstract
Copyright of Archives of Hellenic Medicine / Arheia Ellenikes Iatrikes is the property of Athens Medical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
33. Minimally invasive interventional procedures for osteoarthritis and inflammatory arthritis: A systematic review and meta-analysis.
- Author
-
Ciaffi, Jacopo, Papalexis, Nicolas, Vanni, Elena, Miceli, Marco, Faldini, Cesare, Scotti, Lorenza, Zambon, Antonella, Salvarani, Carlo, Caporali, Roberto, Facchini, Giancarlo, and Ursini, Francesco
- Abstract
to summarize the evidence on the efficacy of minimally invasive interventional procedures such as radiofrequency ablation (RFA) and transcatheter arterial embolization (TAE) in patients with osteoarthritis or inflammatory arthritis. a literature search was conducted in PubMed and Web of Science databases. Both randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSI) were included. The results were organized according to the treated anatomical site: knee, hip, foot and ankle, shoulder, hand and wrist, sacroiliac joints. Data about treatment efficacy were extracted. The main outcome was change in pain intensity using the 0–10 visual analog scale (VAS) from baseline to 1 month. Additional timepoints at 3, 6 and 12 months were assessed. Change in functional status was evaluated. Pooled estimates were calculated as the mean difference (MD) and 95 % confidence interval relative to baseline. The meta-analyses of RCTs and NRSI were conducted separately. of the 4599 retrieved articles, 164 were included in the review and, considering all the established timepoints, 111 (38 RCTs and 73 NRSI) were selected for the meta-analysis. Only one article described patients with inflammatory arthritis. In the meta-analysis of RCTs, one month after the procedure, MD in VAS was -3.98 (-4.41 to -3.55; k = 21) for knee RFA, and -3.18 (-3.96 to -2.39; k = 8) for sacroiliac joints RFA. In the meta-analysis of NRSI, MD in VAS was -4.12 (-4.63 to -3.61; k = 23) for knee RFA, -3.84 (-4.77 to -2.92; k = 7) for knee TAE, -4.34 (-4.96 to -3.71; k = 2) for hip RFA, -3.83 (-4.52 to -3.15; k = 3) for shoulder RFA and -4.93 (-5.58 to -4.28; k = 14) for sacroiliac joints RFA. Significant decrease in pain intensity was found also at 3, 6 and 12 months. Additionally, functional status improved at all the assessed timepoints. minimally invasive interventional procedures can improve pain and functional status of patients affected by OA or chronic sacroiliac pain of degenerative origin. Further research is warranted in the field of inflammatory rheumatic diseases. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
34. Staphylococcus aureus mediastinitis following a skin infection in a non-immunocompromised patient: A case report
- Author
-
Mantzouranis, K. Georgakopoulou, V.E. Mermigkis, D. Damaskos, C. Garmpis, N. Papalexis, P. Gkoufa, A. Drossos, P. Chlapoutakis, S. Garmpi, A. Sklapani, P. Trakas, N. Tsiafaki, X.
- Abstract
Mediastinitis is a severe inf lammation of the structures located in the mid-chest cavity. Three main causes of infective mediastinitis are traditionally recognized: Deep infection of a sternal wound following cardiothoracic surgery, perforation of the esophagus, and the descending necrotizing mediastinitis as a result of odontogenic, pharyngeal or cervical infections. Mediastinitis, as a complication of skin infection with hematogenous spread is infrequent. Methicillin-resistant Staphylococcus aureus (MRSA) is a gram-positive bacteria, and is responsible for numerous severe infections. MRSA mediastinitis is a rare infection and is typically associated with complications of sternotomy and retropharyngeal abscesses. Here, the second known case of mediastinitis of a hematoge-nous origin in a non-immunocompromised 41-year-old patient following primary skin infection, accompanied by sternal osteomyelitis, lung consolidation and pleural effusion is described; MRSA was the responsible pathogen. The clinical course was favorable after 6 weeks of antibiotics administra-tion without drainage or surgical intervention. © 2021, Spandidos Publications. All rights reserved.
- Published
- 2021
35. Asymptomatic SARS-CoV-2 infection in an unvaccinated 97-year-old woman: A case report
- Author
-
Georgakopoulou, V.E. Papalexis, P. Sanos, C. Bitsani, A. Garmpi, A. Damaskos, C. Garmpis, N. Gkoufa, A. Chlapoutakis, S. Sklapani, P. Mantzouranis, K. Trakas, N. Spandidos, D.A.
- Abstract
Coronavirus disease (COVID-19) is an infection caused by the newly detected coronavirus, SARS-CoV-2. The majority of individuals will exhibit mild to moderate illness. Older individuals, and those suffering from co-existing diseases have a greater probability of experiencing a serious illness. Moreover, elderly patients have higher mortality rates than younger patients, especially those who are unvaccinated. Asymptomatic infection is mostly observed in individuals who are younger, as younger patients are more likely to exhibit a stronger immune response to the infection; aging is characterized by the decline immune function. In this article, a rare case of an unvaccinated 97-year-old woman is described who was admitted to Laiko General Hospital due to altered levels of consciousness, hypotension and a hematoma of the thoracic region, and tested positive for SARS-CoV-2 nucleic acid in a nasopharyngeal specimen and positive for IgG antibodies against the SARS-CoV-2 spike protein without a history of consistent manifestations, indicating a past asymptomatic infection. © 2021, Spandidos Publications. All rights reserved.
- Published
- 2021
36. Characteristics and outcomes of cancer patients who develop pulmonary embolism: A cross-sectional study
- Author
-
Chlapoutakis, S. Georgakopoulou, V.E. Trakas, N. Kouvelos, G. Papalexis, P. Damaskos, C. Sklapani, P. Grivas, A. Gouveris, P. Tryfonopoulos, D. Tzovaras, A. Ardavanis-Loukeris, G. Grouzi, E. Spandidos, D.A. Matsagkas, M.
- Abstract
Pulmonary embolism (PE), along with deep vein thrombosis, are collectively known as venous thromboembo- lism (VTE). Predisposing factors for PE include post-operative conditions, pregnancy, cancer and an advanced age; of note, a number of genetic mutations have been found to be associ- ated with an increased risk of PE. The association between cancer and VTE is well-established, and cancer patients present a higher risk of a thrombotic event compared to the general population. In addition, PE is a significant cause of morbidity and mortality among cancer patients. The aim of the present study was to illustrate the clinical characteristics, laboratory findings, radiology features and outcomes of cancer patients who developed PE, collected from an anticancer hospital. For this purpose, adult cancer patients diagnosed with PE by imaging with computed tomography pulmonary angiography were enrolled. The following data were recorded: Demographics, comorbidities, type of cancer, time interval between cancer diagnosis and PE occurrence, the type of therapy received and the presence of metastases, clinical signs and symptoms, predisposing factors for PE development, laboratory data, radiological findings, electrocardiography findings, and the type of therapy received for PE and outcomes in a follow-up period of 6 months. In total, 60 cancer patients were enrolled. The majority of the cancer patients were males. The most common type of cancer observed was lung cancer. The majority of cases of PE occurred within the first year from the time of cancer diagnosis, while the majority of patients had already developed metastases. In addition, the majority of cancer patients had received chemotherapy over the past month, while they were not receiving anticoagulants and had central obstruction. A large proportion of patients had asymptomatic PE. The in-hospital mortality rate was 13.3% and no relapse or mortality were observed during the follow-up period. The present study demonstrates that elevated levels of lactic acid and an increased platelet count, as well as low serum levels of carcinoembryonic antigen, albumin and D-dimer, may be potential biomarkers for asymptomatic PE among cancer patients. © 2021 Spandidos Publications. All rights reserved.
- Published
- 2021
37. Suspected Diagnosis of Munchausen's Syndrome: Awareness for the Radiology Community.
- Author
-
Spinnato, Paolo, Masuzzo, Oriana, Tuè, Giovanni, Tucci, Francesco, Papalexis, Nicolas, and Miceli, Marco
- Published
- 2024
- Full Text
- View/download PDF
38. STUDY OF THE PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC A SUBUNIT (PIK3CA) GENE EXPRESSION IN TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM
- Author
-
Papalexis, P., Kontos, C. K., Christopoulos, P., Papadias, K., Anagnou, N., Kreatsas, G., and Scorilas, A.
- Published
- 2010
39. Medication use by athletes during the Athens 2004 Paralympic Games
- Author
-
Tsitsimpikou, C, Jamurtas, A, Fitch, K, Papalexis, P, and Tsarouhas, K
- Published
- 2009
- Full Text
- View/download PDF
40. NMR metabolic profiling of Greek Pistacia lentiscus leaves and fruit extracts for the identification of biomarkers with skin beneficial effects
- Author
-
Cheilari, A. Papalexis, P. Vontzalidou, A. Dina, E. and Smyrnioudis, I Aligiannis, N.
- Published
- 2019
41. Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing in vitro fertilization
- Author
-
Moragianni, D. Dryllis, G. Andromidas, P. Kapeta-Korkouli, R. Kouskouni, E. Pessach, I. Papalexis, P. Kodonaki, A. Athanasiou, N. Pouliakis, A. Baka, S.
- Subjects
female genital diseases and pregnancy complications - Abstract
Assisted reproductive techniques including in vitro fertilization (IVF) are being used increasingly worldwide and screening for genital tract infections (GTIs) is recommended prior to treatment as their presence may affect the success rate of IVF. The current study aimed to assess the possible associations between GTI-associated factors and reproductive outcome in a group of reproductive age fertile females and infertile females receiving IVF. A total of 111 infertile women enrolled in an IVF programme (Group A) and 104 fertile women (mothers of at least one child; Group B) underwent microbiological screening of vaginal and cervical samples. All samples were cultured using different protocols for aerobic pathogens, bacterial vaginosis (BV), Ureaplasma urealyticum, Mycoplasma hominis, Chlamydia trachomatis and human papilloma virus (HPV). Although each group were comparable in age, more infertile women were >30 years (P=0.0064), had a higher education level (P=0.0001) and were smokers (P=0.007). Only BV (P=0.0013) was more prevalent in Group A. Of the 111 infertile females who were scheduled for IVF, 32 females had a successful pregnancy (Group C) and 79 females exhibited IVF failure (Group D). Tubal factor (P=0.012), estradiol-2 (E2) levels
- Published
- 2019
42. Use of nutritional supplements contaminated with banned doping substances by recreational adolescent athletes in Athens, Greece
- Author
-
Tsarouhas, K. Kioukia-Fougia, N. Papalexis, P. Tsatsakis, A. Kouretas, D. Bacopoulou, F. Tsitsimpikou, C.
- Abstract
Although the use of nutritional supplements by adult athletes has been extensively studied, information on supplements consumption by adolescent athletes is still limited. The present study reports on the use of nutritional supplements contaminated with banned doping substances among 170 recreational adolescent athletes from eleven, randomly selected, gym centres, in Athens, Greece. Nutritional supplements consumption was reported by almost 60% of the study population, with proteins/amino acids and vitamins being the most popular. Nine per cent of the users were found to consume nutritional supplements contaminated with anabolic steroids, prohormones, selective androgen receptor modulators (SARMs) and aromatase inhibitors, all pharmacological substances with endocrine modulating properties not stated on the label. None of these individuals had previously consulted a physician or a nutritionist. A representative sample (ca 15%) of the protein/aminoacids and creatine preparations used by the study population were also tested and found free from doping substances. The majority (63%) of adolescents purchased products from the internet. In conclusion, exercising adolescents can have easy access to contaminated nutritional supplements and “black market” products, which could constitute a risk for public health. Low level of awareness and low involvement of medical care professionals among recreational adolescent athletes is also observed. © 2018 Elsevier Ltd
- Published
- 2018
43. NMR metabolic profiling of Greek Pistacia lentiscus leaves and fruit extracts for the identification of biomarkers with skin beneficial effects
- Author
-
Cheilari, A, additional, Papalexis, P, additional, Vontzalidou, A, additional, Dina, E, additional, Smyrnioudis, I, additional, and Aligiannis, N, additional
- Published
- 2019
- Full Text
- View/download PDF
44. Biogenic amines in food as a public health concern An outline of histamine food poisoning.
- Author
-
Chaidoutis, E., Migdanis, A., Keramydas, D., and Papalexis, P.
- Subjects
BIOGENIC amines ,HISTAMINE ,FOOD poisoning ,FOODBORNE diseases ,PUBLIC health ,NATURAL foods - Abstract
Copyright of Archives of Hellenic Medicine / Arheia Ellenikes Iatrikes is the property of Athens Medical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
45. Electrocardiographic findings compatible with Brugada syndrome in a patient with febrile respiratory infection
- Author
-
Konstantinos Tsarouhas, Papalexis, P., Kafantaris, I., Tsitsimpikou, Ch, Vavetsi, S., and Rentoukas, E.
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Case Report ,cardiovascular diseases - Abstract
Brugada syndrome is an inherited autosomal dominant-type disease characterized by ST-segment abnormalities and increased fatal ventricular tachyarrhythmias. We hereby present a 57-years-old patient with no symptoms or history of cardiovascular disease, diagnosed with febrile respiratory infection (39℃). Electrocardiographic (ECG) findings were typical of Brugada-like type I syndrome that gradually turned to Brugada type II and III, following fever remission, and finally became normal. Other clinical evaluation tests (echocardiographic evaluation, treadmill stress test, Holter ECG, procainamide provocation test) did not relate to Brugada syndrome.
- Published
- 2010
46. Dynamic investigation of centralized and decentralized storage systems for a district heating network
- Author
-
Bellos, Evangelos, Iliadis, Petros, Papalexis, Christos, Rotas, Renos, Nikolopoulos, Nikos, Kosmatopoulos, Elias, and Halmdienst, Christian
- Abstract
District heating is an efficient and promising way to cover the residential space-heating and domestic hot water needs, resulting in economic and environmental benefits, especially if operated by renewable power stations, when compared to fossil fuels. In this direction, the present study investigates in detail a district heating network with novel decentralized storage for domestic hot water (enerboxx scenario), over centralized storage systems, applying a specific schedule-based approach for the coordinated hot water tank charging. The goal of this design is to properly control the system by charging it at predetermined time periods during the day aiming at i) diminishing the thermal losses and ii) reducing the thermal demand from the grid, over the period of a day. The simulation is conducted with a newly developed component-based tool, called INTEMA, which is based on the Modelica language. This encompasses the ability to discretize with high temporal resolution and adjustable time steps the overall grid configuration, with the support of customizable level of detail models for simulating key system components such as the storage tanks, the piping and the dwelling needs, as well as the application of an advanced control system over the district heating network and the dwellings. More specifically, a combined control system that controls both operating parameters in the network and inside the dwellings is applied. The developed system model is verified against available data for a standard centralized storage system (reference scenario) and afterwards, the novel decentralized design is compared against corresponding results of the standard system, as concerns key operational parameters; indicatively the temperature levels of the hot water and the heat load demand. The analysis is conducted for a heating network of 9 dwellings in Austria, which have an underfloor heating system, a system for covering the domestic hot water demand, considering also that each of these 9 dwellings is characterized by a unique demand profile. It was found that the decentralized approach leads to lower demand and there are energy savings of 18 % compared to the reference scenario, while the thermal losses are reduced by about 22 %. Moreover, a parametric study regarding the storage tank volume and the heat exchanger thermal transmittance in the tank is conducted, in order to examine the impact of these design parameters on the system dynamic behavior.
- Published
- 2022
- Full Text
- View/download PDF
47. Plasmodium falciparumHistidine-rich Protein-2 (PfHRP2) Modulates the Redox Activity of Ferri-protoporphyrin IX (FePPIX)
- Author
-
Mashima, Ryuichi, Tilley, Leann, Siomos, Mary-Anne, Papalexis, Vicki, Raftery, Mark J., and Stocker, Roland
- Abstract
Histidine-rich protein-2 from Plasmodium falciparum(PfHRP2) binds up to 50 molecules of ferri-protoporphyrin IX (FePPIX) (Choi, C. Y., Cerda, J. F., Chu, H. A., Babcock, G. T., and Marletta, M. A. (1999)Biochemistry38, 16916–16924). We reasoned that thePfHRP2-FePPIX complex has antioxidant properties that could be beneficial to the parasite. Therefore, we examined whether binding to PfHRP2 modulated the redox properties of FePPIX. We observed that PfHRP2 completely inhibited the auto-oxidation of ascorbate mediated by free FePPIX. We also investigated the peroxidase activity of PfHRP2-FePPIX using 13-hydroperoxy-9,11-octadienoate (18:2-OOH) as substrate. Reaction ofPfHRP2-FePPIX with 18:2-OOH in the presence of added reducing agents gave 13-hydroxy-9,11-octadienoate (18:2-OH) as a major product and 13-keto-9,11-octadienoate (18:2=O) and 9,12,13-trihydroxy-10-octadecaenoate as minor products. Binding of FePPIX to PfHRP2 lowered the rate of decomposition of 18:2-OOH and increased the 18:2-OH to 18:2=O ratio. Similar to other authentic peroxidases, phenols, amines, and biological reductants like ascorbate promoted 18:2-OH production, and NaCN inhibited 18:2-OH production. Thioanisole also acted as a reductant and was converted to thioanisole sulfoxide, suggesting formation of compound I during the reaction. These data show that PfHRP2 modulates the redox activity of FePPIX and that the PfHRP2-FePPIX complex may have previously unrecognized antioxidant properties.
- Published
- 2002
- Full Text
- View/download PDF
48. Histidine-rich protein 2 of the malaria parasite, Plasmodium falciparum, is involved in detoxification of the by-products of haemoglobin degradation
- Author
-
Papalexis, V., Siomos, M. A., Campanale, N., Guo, X. g., Kocak, G., Foley, M., and Tilley, L.
- Published
- 2001
- Full Text
- View/download PDF
49. Electrocardiographic findings compatible with Brugada syndrome in a patient with febrile respiratory infection.
- Author
-
Tsarouhas, K., Papalexis, P., Kafantaris, I., Tsitsimpikou, Ch., Vavetsi, S., and Rentoukas, E.
- Subjects
- *
BRUGADA syndrome , *ELECTROCARDIOGRAPHY , *RESPIRATORY infections , *TACHYARRHYTHMIAS , *STRESS echocardiography , *PATIENTS - Abstract
Brugada syndrome is an inherited autosomal dominant-type disease characterized by ST-segment abnormalities and increased fatal ventricular tachyarrhythmias. We hereby present a 57-years-old patient with no symptoms or history of cardiovascular disease, diagnosed with febrile respiratory infection (39°C). Electrocardiographic (ECG) findings were typical of Brugada-like type I syndrome that gradually turned to Brugada type II and III, following fever remission, and finally became normal. Other clinical evaluation tests (echocardiographic evaluation, treadmill stress test, Holter ECG, procainamide provocation test) did not relate to Brugada syndrome. [ABSTRACT FROM AUTHOR]
- Published
- 2010
50. AS SEEN ON TV.
- Author
-
Christine Papalexis and Veneklasen, Greg
- Subjects
PUPPETEERS ,PUPPET making ,TELEVISION commercials - Abstract
The article focuses on the experiences of the Los Angeles Guild of Puppetry member puppeteers in building and performing puppets in television (TV) commercials in the U.S. It state that René Zendejas, Nancy Mitchell and Pat Brymer have generously demonstrated and shared their efforts of making puppets for various TV commercials respectively. It also notes the significance of TV commercials which have been the main source of employment and creative expression for the puppeteers.
- Published
- 2010
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.