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5. The role of implantable loop recorder in patients with cryptogenic stroke: A systematic review and meta-analysis

Author

Gatzoulis, KonstantinosA, primary, Mavromoustakou, Kiriaki, additional, Katzouridi, Symeoni, additional, Soulaidopoulos, Stergios, additional, Doundoulakis, Ioannis, additional, Papadopoulos, Achilleas, additional, Arsenos, Petros, additional, Sideris, Skevos, additional, Dilaveris, Polychronis, additional, Tsiachris, Dimitris, additional, Kordalis, Athanasios, additional, and Tsioufis, Konstantinos, additional

Published
2023
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6. The Role of Implantable Loop Recorder in Patients with Cryptogenic Stroke: A Systematic Review and Meta‑Analysis.

Author

Mavromoustakou, Kiriaki, Katzouridi, Symeoni, Soulaidopoulos, Stergios, Doundoulakis, Ioannis, Papadopoulos, Achilleas, Arsenos, Petros, Sideris, Skevos, Dilaveris, Polychronis, Tsiachris, Dimitris, Kordalis, Athanasios, Tsioufis, Konstantinos, and Gatzoulis, Konstantinos A.

Subjects
ATRIAL fibrillation risk factors, AMBULATORY electrocardiography, ONLINE information services, MEDICAL databases, META-analysis, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, ISCHEMIC stroke, SYSTEMATIC reviews, MANN Whitney U Test, DISEASE relapse, RISK assessment, T-test (Statistics), DESCRIPTIVE statistics, MEDLINE
Abstract

Objective: The objective of this study was to provide data on implantable loop recorder (ILR)-based atrial fibrillation (AF) rates, recurrent stroke rates, and predictors of AF in patients with cryptogenic stroke (CS) after 1, 6, 12, 24, and 36 months of follow-up. Methods: We searched MEDLINE/PubMed, Cochrane Central Register of Controlled Trials, EMBASE, Web of Science, and reference lists of retrieved reports, which were published by April 30, 2023, which was the date of our last search. We utilized random-effects meta-analysis for detection rates, and meta-regression analysis, t-test (for normally distributed variables), and Mann-Whitney (for skewed variables) for predictor factors. Results: Thirteen studies were analyzed, which included data from 3,377 patients with CS or embolic stroke of undetermined source. The ILR-based AF rates in patients with CS were 4.73% (95% confidence interval [CI] 3.91–5.71) at 1 month, 13.45% (95% CI 12.19–14.81) at 6 months, 17.5% (95% CI 16.25–18.82) at 12 months, 20.69% (95% CI 19–22.49) at 24 months, and 25.98% (95% CI 23.21–28.58) at 36 months. Age and CHA2DS2-VASc score were positively associated with AF detection. Specifically, the mean difference of age and CHA2DS2-VASc score in the group with AF versus the group without AF was 7.47 (95% CI 4.58–10.36, P < 0.001) and 0.75 (95% CI 0.22–1.28, P = 0.01), respectively. Finally, AF detection was positively associated with recurrent strokes with an estimated risk ratio of 1.27 (95% CI 0.69–2.31). Conclusions: There is a correlation between AF detection rate and ILR monitoring duration. One out of eight patients was diagnosed with AF after 6 months of follow-up and about one quarter after 3 years. Our results demonstrate the critical use of ILRs, especially in older patients, and in patients with high CHA2DS2-VASc scores. [ABSTRACT FROM AUTHOR]

Published
2023
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7. An integrated approach for the management of demolition waste in Cyprus

Author

Kourmpanis, Basilis, Papadopoulos, Achilleas, Moustakas, Konstantinos, Kourmoussis, Fotis, Stylianou, Marinos, and Loizidou, Maria

Subjects
Cyprus -- Environmental aspects, Refuse and refuse disposal -- Methods, Multiple criteria decision making -- Usage, Environmental services industry
Published
2008

10. Clinical characteristics and management of patients with diabetes mellitus and stable coronary artery disease in daily clinical practice. The SCAD–DM Registry

Author

Marketou, Maria E., primary, Vlachopoulos, Charalambos, additional, Hahalis, George, additional, Kafkala, Kristalenia, additional, Kouvelas, Nikolaos, additional, Mantas, Ioannis, additional, Sideris, Antonios, additional, Pisimisis, Evaggelos, additional, Vardas, Emmanouel P., additional, Tzeis, Stylianos, additional, Vardas, Panos E., additional, Dimitroula, Vassiliki, additional, Hatjielefteriou, Christos, additional, Kampouridis, Nikolaos, additional, Karakostas, Georgios, additional, Karanasios, Athanasios, additional, Lambropoulos, Stylianos, additional, Papalisandrou, Fotios, additional, Scoubourdis, Emmanouil, additional, Smirnioudis, Nikolaos, additional, Adamopoulos, Eleftherios, additional, Aggelopoulos, Georgios, additional, Albanis, Charalampos, additional, Amaslidis, Alexandros, additional, Andreopoulou, Maria, additional, Antoniou, Ilias, additional, Apostolou, Ilias, additional, Afaras, Georgios, additional, Arfaras, Vasileios, additional, Aronis, Konstantinos, additional, Askar, Georgios, additional, Athanasiou, Christos, additional, Beroukas, Sokratis Avlonitis Antonios, additional, Chorozopoulos, Emmanouil, additional, Chrysomallis, Nikolaos, additional, Davos, Konstantinos, additional, Demerouti, Eftichia, additional, Dimopoulos, Vasileios, additional, Dimoulis, Nikolaos, additional, Drakoulidis, Vasileios, additional, Faka, Kiriaki, additional, Fotiadis, Dimitrios, additional, Galapis, Alexandros, additional, Giakoumis, Antonios, additional, Goupios, Ioannis, additional, Harbas, Christos, additional, Hatjiioakeimidis, Vasileios, additional, Hondrokoukis, Georgios, additional, Kalaras, Panagiotis, additional, Kanakaraki, Marina, additional, Kapetanios, Konstantinos, additional, Karasavvidis, Vasileios, additional, Karonis, Theodoros, additional, Karydakis, Andreas, additional, Katsaris, Christos, additional, Katsikas, Christos, additional, Katsas, Konstantinos, additional, Kazantzidis, Sokratis, additional, Kipouridis, Nikolaos, additional, Kokani, Eirini, additional, Kolios, Georgios, additional, Konstantinidis, Ilias, additional, Konstantinou, Themistoklis, additional, Konstantinou, Marios, additional, Kontopoulos, Georgios, additional, Kontoroupis, Georgios, additional, Koroniotis, Georgios, additional, Kotidis, Apostolos, additional, Koukosi, Chrysanthi, additional, Kouremetis, Mihail, additional, Kouris, Christos, additional, Kouskos, Georgios, additional, Koutras, Konstantinos, additional, Koutsibanis, Georgios, additional, Krontira, Harikleia, additional, Lalenis, Konstantinos, additional, Liatas, Christos, additional, Lillis, Leonidas, additional, Limperatos, Grigorios, additional, Liodakis, Emmanouil, additional, Liropoulos, Stavros, additional, Livaditis, Ioannis, additional, Logothetis, Dimitrios, additional, Lolaka, Maria, additional, Loukidelis, Georgios, additional, Mablekos, Georgios, additional, Manousakis, Antonios, additional, Marinakis, Nikolaos, additional, Markou, Dimitrios, additional, Markou, Virginia, additional, Matziridis, Anestis, additional, Mavraganis, Panagiotis, additional, Mavridis, Vasileios, additional, Mavrodimitrakis, Ioannis, additional, Migias, Georgios, additional, Mitropoulos, Dimitrios, additional, Mitroulas, Christos, additional, Nikiforos, Savvas, additional, Nikolaidis, Vasileios, additional, Nikopoulos, Christos, additional, Oikonomidis, Nikoloaos, additional, Panagiotopoulos, Konstantinos, additional, Panagoulias, Georgios, additional, Panou, Anna, additional, Pantelakis, Ioannis, additional, Papadopoulos, Achilleas, additional, Papadopoulos, Apostolos, additional, Papaioannou, Georgios, additional, Papamichail, Andreas, additional, Papanastasiou, Soultana, additional, Papas, Panagiotis, additional, Papavasileiou, Eleftherios, additional, Papavasileiou, Vasileios, additional, Patialiakas, Athanasios, additional, Patsilinakos, Alexandros, additional, Pechlivanidis, Georgios, additional, Petrogiannis, Spiridon, additional, Pontikakis, Nikolaos, additional, Parissis, Charalampos, additional, Patsourakos, Fotios, additional, Pisimisis, Evangelos, additional, Pittaras, Andreas, additional, Plastiras, Sotirios, additional, Platis, Athanasios, additional, Poulikarakos, Panagiotis, additional, Prionidis, Markos, additional, Psarogianni, Paraskevi, additional, Psathakis, Emmanouil, additional, Psirropoulos, Dimitrios, additional, Riga, Maria, additional, Risgits, Ali, additional, Rosmarakis, Evangelos, additional, Samartzi, Maria, additional, Sarris, Isidoros, additional, Sassalos, Konstantinos, additional, Savvalas, Dimitrios, additional, Siliogas, Georgios, additional, Simeonidis, David, additional, Sinos, Loukas, additional, Skanavis, Andreas, additional, Skordas, Achilleas, additional, Sklirou, Vassiliki, additional, Skotiniotis, Iason, additional, Spanos, Anastasios, additional, Sratech, Dimitrios, additional, Stathopoulos, Christos, additional, Stavropoulos, Rafail, additional, Stavrotheodoros, Christos, additional, Stefanakis, Emmanouil, additional, Stefanis, Konstantinos, additional, Stefopoulos, Christos, additional, Stergiou, Dimitrios, additional, Svolis, Konstantinos, additional, Toulis, Konstantinos, additional, Tsakonas, Kallinikos, additional, Tsamis, Nikolaos, additional, Tzamtzi-Mastaka, Eleni, additional, Tzeltzes, Georgios, additional, Tsiantis, Ioannis, additional, Tsiotika, Theodora, additional, Vachliotis, Vasileios, additional, Vakalis, Ioannis, additional, Vardakis, Konstantinos, additional, Vassilopoulos, Alexandros, additional, Vlahou, Georgia, additional, Vogas, Vasileios, additional, Voukelatou, Evropia, additional, Vrettos, Nikiforos, additional, Xenos, Dionisios, additional, Zagoridis, Konstantinos, additional, Zafiriou, Tsilla, additional, Zafiris, Christos, additional, Zaharia, Maria, additional, Zampetakis, Fanourios, additional, and Zouganelis, Vasileios, additional

Published
2021
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12. Comparison of Triflusal with Aspirin in the Secondary Prevention of Atherothrombotic Events; Α Randomised Clinical Trial

Author

Kalantzi, Kallirroi I., primary, Ntalas, Ioannis V., additional, Chantzichristos, Vasileios G., additional, Tsoumani, Maria E., additional, Adamopoulos, Dimitrios, additional, Asimakopoulos, Christos, additional, Bourdakis, Adamantios, additional, Darmanis, Petros, additional, Dimitriadou, Alexandra, additional, Gkiokas, Stefanos, additional, Ipeirotis, Konstantinos, additional, Kitikidou, Kyriaki, additional, Klonaris, Ioannis, additional, Kostaki, Aglaia, additional, Logothetis, Dimitrios, additional, Mainas, Konstantinos, additional, Mais, Theodoros, additional, Maragiannis, Athanasios, additional, Martiadou, Konstantina, additional, Mavronasos, Konstantinos, additional, Michelongonas, Ioannis, additional, Mitropoulos, Dimitrios, additional, Papadimitriou, Georgios, additional, Papadopoulos, Achilleas, additional, Papaioakeim, Miltiadis, additional, Sofillas, Kosmas, additional, Stabola, Sotiria, additional, Stefanakis, Emmanouil, additional, Stergiou, Dimitrios, additional, Thoma, Maria, additional, Zenetos, Alexandros, additional, Zisekas, Stergios, additional, Goudevenos, John A., additional, Panagiotakos, Demosthenes B., additional, and Tselepis, Alexandros D., additional

Published
2019
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13. Diagnosis and management of phantom tachycardias based on an electrophysiologically guided approach

Author

Tsiachris, Dimitris Koutagiar, Iosif Gatzoulis, Konstantinos A. and Arsenos, Petros Rigatou, Aggeliki Dilaveris, Polychronis and Sideris, Skevos Papadopoulos, Achilleas Kritikos, Alekos and Stefanadis, Christodoulos Tousoulis, Dimitris

Subjects
cardiovascular system
Abstract

Background: Non-documented palpitations, or phantom tachycardias, are palpitations deemed to be of unknown origin after evaluation with conventional diagnostic tools, such as 12-lead electrocardiogram and Holter recordings. Our aim was to determine the diagnostic value of an electrophysiologic study (EPS) and its role in the management of patients presenting with non-documented palpitations. Methods: We performed EPS in 78 consecutive patients with repeatable, poorly tolerated symptoms of paroxysmal, non-documented tachycardia, the absence of structural heart disease and at least one 24-h Holter recording. The duration and frequency of palpitations was registered in each patient. Results: Long-lasting palpitations (> 1 hour) were present in 15.4% of patients. Half of patients reported symptoms less often than once per week. Only 13/ 78 patients (16.6%) had normal EPS findings, while dual pathways at the AV node +/- echo beats were identified in another 13 patients without inducible tachycardia. At least one tachycardia event was induced in 52 patients (66.6%). AVNRT was provoked in 32 patients (41.2%). Ablation was performed in 14/52 patients with inducible tachycardia (26.9%). Slow pathway ablation was also performed in three patients with dual AV pathways and atrial echo-beats but without provoked tachycardia. Follow-up data were available in 52 patients, and 84.6% had fewer or no clinical recurrences. Conclusions: EPS is safe and of enhanced diagnostic value in patients with unexplained palpitations because only 1/6 had negative results. EPS also provided an explanation about the mechanism of arrhythmia and successfully guided the management of these patients, as well as enhanced improvement in the quality of life. (C) 2016 Hellenic Cardiological Society. Publishing services by Elsevier B.V.

Published
2016

14. Comparison of Triflusal with Aspirin in the Secondary Prevention of Atherothrombotic Events; A Randomised Clinical Trial

Author

Kalantzi, Kallirroi I., Ntalas, Ioannis V., Chantzichristos, Vasileios G., Tsoumani, Maria E., Adamopoulos, Dimitrios, Asimakopoulos, Christos, Bourdakis, Adamantios, Darmanis, Petros, Dimitriadou, Alexandra, Gkiokas, Stefanos, Ipeirotis, Konstantinos, Kitikidou, Kyriaki, Klonaris, Ioannis, Kostaki, Aglaia, Logothetis, Dimitrios, Mainas, Konstantinos, Mais, Theodoros, Maragiannis, Athanasios, Martiadou, Konstantina, Mavronasos, Konstantinos, Michelongonas, Ioannis, Mitropoulos, Dimitrios, Papadimitriou, Georgios, Papadopoulos, Achilleas, Papaioakeim, Miltiadis, Sofillas, Kosmas, Stabola, Sotiria, Stefanakis, Emmanouil, Stergiou, Dimitrios, Thoma, Maria, Zenetos, Alexandros, Zisekas, Stergios, Goudevenos, John A., Panagiotakos, Demosthenes B., and Tselepis, Alexandros D.

Abstract

Background: Triflusal has demonstrated an efficacy similar to aspirin in the prevention of vascular events in patients with acute myocardial infarction () and ischaemic stroke but with less bleeding events. Objective: We performed a randomised, multicentre, phase 4 clinical trial to compare the clinical efficacy and safety of triflusal versus aspirin, administered for 12 months in patients eligible to receive a cyclooxygenase-1 (COX-1) inhibitor. Methods: Patients with stable coronary artery disease or with a history of non-cardioembolic ischaemic stroke were randomly assigned to receive either triflusal 300 mg twice or 600 mg once daily or aspirin 100 mg once daily for 12 months. The primary efficacy endpoint was the composite of: (a) , (b) stroke (ischaemic or haemorrhagic), or, (c) death from vascular causes for the entire follow-up period. The primary safety endpoints were the rate of bleeding events as defined by Bleeding Academic Research Consortium (BARC) criteria. Results: At 12-month follow-up, an equivalent result was revealed between the triflusal (n=559) and aspirin (n=560) in primary efficacy endpoint. Specifically, the combined efficacy outcome rate (i.e. MI, stroke or death from vascular causes) difference was equal to -1.3% (95% confidence interval -1.1 to 3.5) and lied within the a-priori defined equivalence interval (p<0.001). Regarding the primary safety endpoints, patients on triflusal treatment were 50% less likely to develop bleeding events according to the BARC criteria, and especially any clinically overt sign of haemorrhage that requires diagnostic studies, hospitalisation or special treatment (BARC type 2). Conclusion: The efficacy of triflusal in the secondary prevention of vascular events is similar to aspirin when administered for 12 months. Importantly, triflusal significantly reduced the incidence of and showed a better safety profile compared with aspirin. (ASpirin versus Triflusal for Event Reduction In Atherothrombosis Secondary prevention, ASTERIAS trial; Clinical Trials.gov Identifier: NCT02616497).

Published
2019
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22. MANAGEMENT OF WASTE FROM ELECTRICAL AND ELECTRONI EQUIPMENT IN CYPRUS -- A CASE STUDY.

Author

Kourmousis, Fotis, Moustakas, Konstantinos, Papadopoulos, Achilleas, Inglezakis, Vassilis, Avramikos, Ilias, and Loizidou, Maria

Abstract

Waste from Electric and Electronic Equipment (WEEE) constitute one of the most complicated solid waste streams, in terms of its composition, and, as a result, it is difficult to be effectively managed. In addition, there is a lack of an organized mechanism for the official recording of its quantities in the European Union. Thus, the available quantitative data derive from certain evaluation projects and estimation models. This paper analyses the current waste management practices in Cyprus as a case study and presents the estimated quantities of WEEE. All this data is considered valuable and can be used as a basis for making the most suitable recommendations, in order to deal with the problem effectively and promote sustainable waste management solutions, such as its reuse and recycling. [ABSTRACT FROM AUTHOR]

Published
2011
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