1. The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation
- Author
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Weber, Daniela, Frauenschläger, Katrin, Ghimire, Sakhila, Peter, Katrin, Panzer, Isabella, Hiergeist, Andreas, Weber, Markus, Kutny, Daniel, Wolff, Daniel, Grube, Matthias, Huber, Elisabeth, Oefner, Peter, Gessner, Andre, Hehlgans, Thomas, Herr, Wolfgang, and Holler, Ernst
- Subjects
Biopsy ,610 Medizin ,Graft vs Host Disease ,lcsh:Medicine ,Pathology and Laboratory Medicine ,Biochemistry ,Epithelium ,Defensins ,Animal Cells ,Medicine and Health Sciences ,lcsh:Science ,ALPHA-DEFENSINS ,GVHD ,MORTALITY ,INTERLEUKIN-22 ,ddc:610 ,Immune System Proteins ,Antimicrobials ,Microbiota ,Drugs ,Genomics ,Biodiversity ,Bacterial Pathogens ,surgical procedures, operative ,Medical Microbiology ,Acute Disease ,Small Intestine ,Cellular Types ,Anatomy ,Pathogens ,Research Article ,Adult ,Paneth Cells ,Immunology ,Surgical and Invasive Medical Procedures ,Microbial Genomics ,Microbiology ,Microbial Control ,Genetics ,Humans ,Transplantation, Homologous ,Microbial Pathogens ,Retrospective Studies ,Pharmacology ,lcsh:R ,Biology and Life Sciences ,Proteins ,Epithelial Cells ,Cell Biology ,Large Intestine ,Gastrointestinal Tract ,Biological Tissue ,Gene Expression Regulation ,lcsh:Q ,Microbiome ,Digestive System ,human activities ,Antimicrobial Cationic Peptides ,Stem Cell Transplantation - Abstract
Intestinal microbiota disruption is associated with acute gastrointestinal (GI) Graft-versus-Host Disease (GvHD) and poor outcome after allogeneic stem cell transplantation (ASCT). Here, in a retrospective analysis of 200 patients undergoing ASCT at the Regensburg University Medical Center, we assessed the relative expression of Paneth cell antimicrobial peptides (AMPs), Human Defensins (HD) 5 and 6 and regenerating islet-derived 3 alpha (Reg3 alpha), in 292 human intestinal biopsies as well as Reg3a serum levels in relation to acute GI GvHD. In the absence of GI GvHD, the relative expression of Paneth cell AMPs was significantly higher in the small intestine (duodenum to ileum) than in the stomach and large intestine (cecum to rectum) for Reg3a (p
- Published
- 2017