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2. Establishment of computational biology in Greece and Cyprus: Past, present, and future.

Author

Chasapi, Anastasia, Aivaliotis, Michalis, Angelis, Lefteris, Chanalaris, Anastasios, Iliopoulos, Ioannis, Kappas, Ilias, Karapiperis, Christos, Kyrpides, Nikos C, Pafilis, Evangelos, Panteris, Eleftherios, Topalis, Pantelis, Tsiamis, George, Vizirianakis, Ioannis S, Vlassi, Metaxia, Promponas, Vasilis J, and Ouzounis, Christos A

Subjects
Humans, Computational Biology, History, 20th Century, History, 21st Century, Publications, Greece, Cyprus, Bioinformatics, Biological Sciences, Information and Computing Sciences, Mathematical Sciences
Abstract

We review the establishment of computational biology in Greece and Cyprus from its inception to date and issue recommendations for future development. We compare output to other countries of similar geography, economy, and size—based on publication counts recorded in the literature—and predict future growth based on those counts as well as national priority areas. Our analysis may be pertinent to wider national or regional communities with challenges and opportunities emerging from the rapid expansion of the field and related industries. Our recommendations suggest a 2-fold growth margin for the 2 countries, as a realistic expectation for further expansion of the field and the development of a credible roadmap of national priorities, both in terms of research and infrastructure funding.

Published
2019

3. Impact of religious fasting on metabolic and hematological profile in both dyslipidemic and non-dyslipidemic fasters

Author

Papazoglou, Andreas S., Moysidis, Dimitrios V., Tsagkaris, Christos, Vouloagkas, Ioannis, Karagiannidis, Efstratios, Kartas, Anastasios, Vlachopoulos, Nikolaos, Konstantinou, Georgios, Sofidis, Georgios, Stalikas, Nikolaos, Panteris, Eleftherios, Deda, Olga, Otountzidis, Nikolaos, Karvounis, Haralambos, Gika, Helen, Theodoridis, Georgios, and Sianos, Georgios

Published
2022
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7. Polypharmacy and Major Adverse Events in Atrial Fibrillation

Author

Tsagkaris, Christos, Papazoglou, Andreas S., Kartas, Anastasios, Samaras, Athanasios, Moysidis, Dimitrios V., Vouloagkas, Ioannis, Baroutidou, Amalia, Bekiaridou, Alexandra, Patsiou, Vasiliki, Chatzisolomou, Antreas, Panteris, Eleftherios, Karagiannidis, Efstratios, Karvounis, Haralambos, Tzikas, Apostolos, and Giannakoulas, George

Published
2022
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10. Correlation of the severity of coronary artery disease with patients' metabolic profile- rationale, design and baseline patient characteristics of the CorLipid trial

Author

Karagiannidis, Efstratios, Sofidis, Georgios, Papazoglou, Andreas S., Deda, Olga, Panteris, Eleftherios, Moysidis, Dimitrios V., Stalikas, Nikolaos, Kartas, Anastasios, Papadopoulos, Anastasios, Stefanopoulos, Leandros, Karvounis, Haralambos, Gika, Helen, Theodoridis, Georgios, and Sianos, Georgios

Published
2021
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11. Added prognostic value of stress-induced hyperglycemia to the GRACE 2.0 risk score for prediction of 1-year major adverse cardiovascular events in patients with ST-elevation myocardial infarction

Author

Stalikas, Nikolaos, primary, Karagiannidis, Efstratios, additional, Papazoglou, Andreas S., additional, Panteris, Eleftherios, additional, Didagelos, Manthos, additional, Ziakas, Antonios, additional, Vassilikos, Vasileios, additional, Giannakoulas, George, additional, and Giannopoulos, George, additional

Published
2023
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13. Untargeted Metabolomics Pilot Study Using UHPLC-qTOF MS Profile in Sows’ Urine Reveals Metabolites of Bladder Inflammation

Author

Pousinis, Petros, primary, Virgiliou, Christina, additional, Mouskeftara, Thomai, additional, Chalvatzi, Sofia, additional, Kroustallas, Fotios, additional, Panteris, Eleftherios, additional, Papadopoulos, Georgios A., additional, Fortomaris, Paschalis, additional, Cernat, Michaela, additional, Leontides, Leonidas, additional, and Begou, Olga, additional

Published
2022
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15. Depression and anxiety levels in a population of Greek male prisoners with a history of dependence.

Author

Papathanasiou, Nestor N., Bismpas, Lazaros, Panteris, Eleftherios, Konsta, Anastasia, Diakogiannis, Ioannis I., and Athanasiadis, Loukas

Subjects
STATE-Trait Anxiety Inventory, KRUSKAL-Wallis Test, NONPARAMETRIC statistics, STATISTICS, RELATIVE medical risk, PRISON psychology, PSYCHOLOGY of men, CORRECTIONAL institutions, PSYCHOLOGY of drug abusers, MENTAL health, MEDICAL care of prisoners, REGRESSION analysis, SYMPTOM Checklist-90-Revised, MANN Whitney U Test, PSYCHOLOGICAL tests, MENTAL depression, QUESTIONNAIRES, DESCRIPTIVE statistics, ANXIETY, DATA analysis software, DATA analysis, LONGITUDINAL method
Abstract

This prospective study aims to report on the prevalence of depression and anxiety levels, in a sample of Greek prisoners with a history of substance and alcohol use. The study comprises 100 male prisoners with a history of substance and/or alcohol use, in the Grevena Correctional Facility, in Northern Greece. BDI AUDIT, DUDIT, CAGE, STAI Y-1 & Y-2 and SCL-90 R were used. Sixty-three percent of study participants stated they had mental health problems. Another 37% stated they were on antidepressants, 16% on anti-anxiety medication, and 7% on antipsychotic medication, while only 34% were not on medication. Linear regression was utilized to identify independent predictors for each of the questionnaires scores, adjusting for age. The prevalence of depression among Greek prisoners with history of substance and alcohol use is much higher than in the general population in Greece and even between other inmate groups. Also anxiety levels of these prisoners were significantly elevated. This is the latest study in Greek prisons and the only one concerning inmates with history of dependence. Therefore, its conclusion of higher than before prevalence of depression and high anxiety level while incarcerated should be considered for diagnosis and therapy strategies in prison. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Biochemical Pathway Analysis via Signature Mining

Author

Panteris, Eleftherios, Swift, Stephen, Payne, Annette, Lui, Xiaohui, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Istrail, Sorin, editor, Pevzner, Pavel, editor, Waterman, Michael, editor, R. Berthold, Michael, editor, Glen, Robert C., editor, Diederichs, Kay, editor, Kohlbacher, Oliver, editor, and Fischer, Ingrid, editor

Published
2005
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17. Machine Learning Algorithm to Predict Obstructive Coronary Artery Disease: Insights from the CorLipid Trial

Author

Panteris, Eleftherios, primary, Deda, Olga, additional, Papazoglou, Andreas S., additional, Karagiannidis, Efstratios, additional, Liapikos, Theodoros, additional, Begou, Olga, additional, Meikopoulos, Thomas, additional, Mouskeftara, Thomai, additional, Sofidis, Georgios, additional, Sianos, Georgios, additional, Theodoridis, Georgios, additional, and Gika, Helen, additional

Published
2022
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20. Additional file 1 of Association of stress induced hyperglycemia with angiographic findings and clinical outcomes in patients with ST-elevation myocardial infarction

Author

Stalikas, Nikolaos, Papazoglou, Andreas S., Karagiannidis, Efstratios, Panteris, Eleftherios, Moysidis, Dimitrios, Daios, Stylianos, Anastasiou, Vasileios, Patsiou, Vasiliki, Koletsa, Triantafyllia, Sofidis, George, Sianos, Georgios, and Giannakoulas, George

Abstract

Additional file 1: Figure S1. Flow-diagram.

Published
2022
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21. Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease

Author

Karagiannidis, Efstratios, primary, Moysidis, Dimitrios V., additional, Papazoglou, Andreas S., additional, Panteris, Eleftherios, additional, Deda, Olga, additional, Stalikas, Nikolaos, additional, Sofidis, Georgios, additional, Kartas, Anastasios, additional, Bekiaridou, Alexandra, additional, Giannakoulas, George, additional, Gika, Helen, additional, Theodoridis, George, additional, and Sianos, Georgios, additional

Published
2022
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25. Impact of religious fasting on metabolic and hematological profile in both dyslipidemic and non-dyslipidemic fasters

Author

Papazoglou, Andreas S., primary, Moysidis, Dimitrios V., additional, Tsagkaris, Christos, additional, Vouloagkas, Ioannis, additional, Karagiannidis, Efstratios, additional, Kartas, Anastasios, additional, Vlachopoulos, Nikolaos, additional, Konstantinou, Georgios, additional, Sofidis, Georgios, additional, Stalikas, Nikolaos, additional, Panteris, Eleftherios, additional, Deda, Olga, additional, Otountzidis, Nikolaos, additional, Karvounis, Haralambos, additional, Gika, Helen, additional, Theodoridis, Georgios, additional, and Sianos, Georgios, additional

Published
2021
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26. Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases

Author

Bompoti, Andreana, primary, Papazoglou, Andreas S., additional, Moysidis, Dimitrios V., additional, Otountzidis, Nikolaos, additional, Karagiannidis, Efstratios, additional, Stalikas, Nikolaos, additional, Panteris, Eleftherios, additional, Ganesh, Vijayakumar, additional, Sanctuary, Thomas, additional, Arvanitidis, Christos, additional, Sianos, Georgios, additional, Michaelson, James S., additional, and Herrmann, Markus D., additional

Published
2021
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27. Current clinical applications and potential perspective of micro-computed tomography in cardiovascular imaging: A systematic scoping review

Author

Papazoglou, Andreas S., primary, Karagiannidis, Efstratios, additional, Moysidis, Dimitrios V., additional, Sofidis, Georgios, additional, Bompoti, Andreana, additional, Stalikas, Nikolaos, additional, Panteris, Eleftherios, additional, Arvanitidis, Christos, additional, Herrmann, Markus D., additional, Michaelson, James S., additional, and Sianos, Georgios, additional

Published
2021
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28. Association of GRACE Risk Score with Coronary Artery Disease Complexity in Patients with Acute Coronary Syndrome

Author

Sofidis, Georgios, primary, Otountzidis, Nikolaos, additional, Stalikas, Nikolaos, additional, Karagiannidis, Efstratios, additional, Papazoglou, Andreas S., additional, Moysidis, Dimitrios V., additional, Panteris, Eleftherios, additional, Deda, Olga, additional, Kartas, Anastasios, additional, Zegkos, Thomas, additional, Daskalaki, Paraskevi, additional, Theodoridou, Niki, additional, Stefanopoulos, Leandros, additional, Karvounis, Haralambos, additional, Gika, Helen, additional, Theodoridis, Georgios, additional, and Sianos, Georgios, additional

Published
2021
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29. MO1011IDENTIFICATION OF EARLY BIOMARKERS OF PERITONEAL MEMBRANE DYSFUNCTION IN CHILDREN ON PERITONEAL DIALYSIS USING METABOLOMICS ANALYSIS -PRELIMINARY RESULTS OF AN ONGOING PROSPECTIVE STUDY

Author

Kondou, Antonia, primary, Dotis, John, additional, Karava, Vasiliki, additional, Begou, Olga, additional, Taparkou, Anna, additional, Panteris, Eleftherios, additional, Gkika, Helen, additional, Theodoridis, Georgios, additional, and Printza, Nikoleta, additional

Published
2021
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30. Micro-CT-Based Quantification of Extracted Thrombus Burden Characteristics and Association With Angiographic Outcomes in Patients With ST-Elevation Myocardial Infarction: The QUEST-STEMI Study

Author

Karagiannidis, Efstratios, primary, Papazoglou, Andreas S, additional, Sofidis, Georgios, additional, Chatzinikolaou, Evangelia, additional, Keklikoglou, Kleoniki, additional, Panteris, Eleftherios, additional, Kartas, Anastasios, additional, Stalikas, Nikolaos, additional, Zegkos, Thomas, additional, Girtovitis, Fotios, additional, Moysidis, Dimitrios V., additional, Stefanopoulos, Leandros, additional, Koupidis, Kleanthis, additional, Hadjimiltiades, Stavros, additional, Giannakoulas, George, additional, Arvanitidis, Christos, additional, Michaelson, James S., additional, Karvounis, Haralambos, additional, and Sianos, Georgios, additional

Published
2021
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32. Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study

Author

Karagiannidis, Efstratios, primary, Papazoglou, Andreas S., additional, Stalikas, Nikolaos, additional, Deda, Olga, additional, Panteris, Eleftherios, additional, Begou, Olga, additional, Sofidis, Georgios, additional, Moysidis, Dimitrios V., additional, Kartas, Anastasios, additional, Chatzinikolaou, Evangelia, additional, Keklikoglou, Kleoniki, additional, Bompoti, Andreana, additional, Gika, Helen, additional, Theodoridis, Georgios, additional, and Sianos, Georgios, additional

Published
2021
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35. Lipidomic-Based Algorithms Can Enhance Prediction of Obstructive Coronary Artery Disease

Author

Mouskeftara, Thomai, Deda, Olga, Liapikos, Theodoros, Panteris, Eleftherios, Karagiannidis, Efstratios, Papazoglou, Andreas S., and Gika, Helen

Abstract

Lipidomics emerges as a promising research field with the potential to help in personalized risk stratification and improve our understanding on the functional role of individual lipid species in the metabolic perturbations occurring in coronary artery disease (CAD). This study aimed to utilize a machine learning approach to provide a lipid panel able to identify patients with obstructive CAD. In this posthoc analysis of the prospective CorLipid trial, we investigated the lipid profiles of 146 patients with suspected CAD, divided into two categories based on the existence of obstructive CAD. In total, 517 lipid species were identified, from which 288 lipid species were finally quantified, including glycerophospholipids, glycerolipids, and sphingolipids. Univariate and multivariate statistical analyses have shown significant discrimination between the serum lipidomes of patients with obstructive CAD. Finally, the XGBoost algorithm identified a panel of 17 serum biomarkers (5 sphingolipids, 7 glycerophospholipids, a triacylglycerol, galectin-3, glucose, LDL, and LDH) as totally sensitive (100% sensitivity, 62.1% specificity, 100% negative predictive value) for the prediction of obstructive CAD. Our findings shed light on dysregulated lipid metabolism’s role in CAD, validating existing evidence and suggesting promise for novel therapies and improved risk stratification.

Published
2024
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36. Screening performance of different methods defining fetal nasal bone hypoplasia as a single and combined marker for the detection of trisomy 21 in the second trimester

Author

Papasozomenou, Panayiota, primary, Athanasiadis, Apostolos P., additional, Zafrakas, Menelaos, additional, Panteris, Eleftherios, additional, Mikos, Themistokles, additional, Daniilidis, Angelos, additional, Loufopoulos, Aristoteles, additional, Assimakopoulos, Efstratios, additional, and Tarlatzis, Basil C., additional

Published
2016
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39. Biochemical Pathway Analysis via Signature Mining.

Author

Berthold, Michael R., Glen, Robert, Diederichs, Kay, Kohlbacher, Oliver, Fischer, Ingrid, Panteris, Eleftherios, Swift, Stephen, Payne, Annette, and Lui, Xiaohui

Abstract

Biology has been revolutionised by microarrays and bioinformatics is now a powerful tool in the hands of biologists. Gene expression analysis is at the centre of attention over the last few years mostly in the form of algorithms, exploring cluster relationships and dynamic interactions between gene variables, and programs that try to display the multidimensional microarray data in appropriate formats so that they make biological sense. In this paper we propose a simple yet effective approach to biochemical pathway analysis based on biological knowledge. This approach, based on the concept of signature and heuristic search methods such as hill climbing and simulated annealing, is developed to select a subset of genes for each pathway that fully describes the behaviour of the pathway at a given experimental condition in a bid to reduce the dimensionality of microarray data and make the analysis more biologically relevant. [ABSTRACT FROM AUTHOR]

Published
2005
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41. Transcultural Adaptation of the Breast Cancer Awareness Measure in a Rural Border Area of Greece.

Author

Papasozomenou P, Eskitzis P, Panteris E, Gerede A, Patsiatzi A, and Zafrakas M

Abstract

Background: Breast cancer awareness is a concept suggesting that awareness of signs and symptoms and early seeking of medical advice may decrease mortality, especially in limited resource settings., Methods: A modified questionnaire based on the breast cancer awareness measure (BCAM) by Cancer Research UK was translated into Greek and used for the first time. Participants were women residing in a rural border area in Greece. For statistical analysis the χ 2 goodness-of-fit and Cramer's V test for categorical comparisons were used and Cronbach's alpha for reliability analysis., Results: In total, 110 women filled out and returned the questionnaire. Respondents appeared to be inappropriately informed regarding the less common warning signs of breast cancer, the most common age of breast cancer occurrence, the national screening program, and the less important risk factors of breast cancer. On the other hand, most women appeared to be confident in recognizing breast changes and seeking medical advice if needed., Conclusions: The translated modified BCAM tool can be used to evaluate breast cancer awareness in Greek women. Future campaigns developed by policymakers should focus on improving breast cancer awareness, especially in socioeconomically deprived areas., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Research Committee - Special Account for Research Grants of the International Hellenic University issued approval 14th Sitting/13.11.2019, Topic 31.3. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: INTERREG IPA Cross-border Cooperation Programme “Greece - Republic of North Macedonia 2014-2020” (CCI 2014 TC 16 I5CB 009). Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Papasozomenou et al.)

Published
2024
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42. Improvement of Medical Students' Empathy Levels After an Intensive Experiential Training on Empathy Skills.

Author

Avlogiari E, Maria Karagiannaki S, Panteris E, Konsta A, and Diakogiannis I

Abstract

Background: EMPATHY IN HEALTHCARE is an intensive 20-hour experiential training program based on mediation techniques and specialized healthcare role-play for clinicians and medical students. It is hypothesized that the training will improve empathy via the intensive experiential techniques implemented., Methods: A total of 50 medical students (25 males/25 females) took the course voluntarily. Empathy was measured using the Jefferson Scale of Empathy-Medical Students Version (JSE-S) (Greek version), before and after the 20-hour training, along with a 6-month follow-up. Gender, age, preferred medical specialty and baseline empathy score were explored as possible moderator variables of the training effect., Results: Empathy increased after training, with a mean JSE-S score improvement of 11.25 points (±8.848) ( P < .001). After 6 months, the mean JSE-S score maintained a difference of 6.514 points (±12.912) ( P < .005). No differences were recorded with regard to gender, age group or medical specialty for the pooled data. Women in the 22-24 year-old age group had a 5-point mean difference ( P = .05), and higher post-training scores than men. Lower initial scorers were the ones that mostly improved, with a 3-fold mean score difference from the higher scorers regardless of gender ( P < .001), while also showing a smaller drop in empathy levels 6 months after the training compared to the higher scorers., Conclusion: Intensive experiential training can improve empathy in a clinical setting. EMPATHY IN HEALTHCARE is a successful training program in improving empathy in medical students, as measured by the JSE-S. A score of 110 and below could be used for selecting medical student candidates who will benefit most from empathy training., Competing Interests: Conflict of Interest: The first author is the president of Alternative Dispute Resolution Hellenic Center which plans to offer the training as a paid service. All other authors have no declarations of interest to report., (2021 authors.)

Published
2021
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