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1. A pilot study on nasal wash galactomannan as a surrogate marker for invasive aspergillosis among hematology patients in Thailand

Author

Natnai Charoonrochana, Natini Jinawath, Pitak Santanirand, Atisak Jiaranaikulwanich, Aruchalean Taweewongsounton, Chavachol Setthaudom, Tananun Tanpaibule, Dootsadeephorn Surin, Pansachee Damronglerd, Wasithep Limvorapitak, Sirapat Rungwittayatiwat, Subencha Pinsai, Pimjai Niparuck, and Porpon Rotjanapan

Subjects
Galactomannan, Nasal wash, Invasive aspergillosis, Acute myeloid leukemia, Hematopoietic stem cell transplant, Medicine, Science
Abstract

Abstract Universal antifungal treatment has been recommended among hematology patients during chemotherapy to prevent invasive aspergillosis (IA) in developed countries, but it remains a significant challenge in resource-limited settings. Identifying at-risk individuals could enhance clinical outcomes. A prospective pilot study was conducted at four Thai tertiary care hospitals from April 2021 to January 2023, aiming to assess the correlation and the potential of nasal wash galactomannan (GM) as an IA predictor in hematology patients. It enrolled all patients with acute myeloid leukemia (AML) requiring induction chemotherapy and those admitted for stem cell transplantation (SCT). Nasal wash fluid samples were collected for galactomannan testing and fungal culture to assess Aspergillus spp. colonization before chemotherapy. The study included 34 AML and SCT patients. Among them, 3/34 tested positive for Aspergillus spp. colonization via nasal wash fungal culture. After six months, 18 (52.9%) patients were diagnosed with IA—15/25 patients with AML and 3/9 SCT recipients. The traditional culture did not predict IA, whereas nasal wash fluid galactomannan cutoff value of 0.46 yielded a sensitivity of 40% and a specificity of 80% for predicting probable and possible IA in patients with AML. However, in the subgroup analysis, the test did not reveal any correlation with IA development. More extensive studies are needed to validate the optimal IA risk prediction strategy.

Published
2024
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2. Real-life effectiveness of COVID-19 vaccine during the Omicron variant-dominant pandemic: how many booster doses do we need?

Author

Paskorn Sritipsukho, Thana Khawcharoenporn, Boonying Siribumrungwong, Pansachee Damronglerd, Nuntra Suwantarat, Araya Satdhabudha, Chanapai Chaiyakulsil, Phakatip Sinlapamongkolkul, Auchara Tangsathapornpong, Pornumpa Bunjoungmanee, Sira Nanthapisal, Chamnan Tanprasertkul, Naiyana Sritipsukho, Chatchai Mingmalairak, Anucha Apisarnthanarak, and Pichaya Tantiyavarong

Subjects
COVID-19, real-life, vaccine, effectiveness, Omicron variant, Thailand, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

ABSTRACTThe surge in coronavirus disease 2019 (COVID-19) caused by the Omicron variants of the severe acute respiratory syndrome coronavirus 2 necessitates researches to inform vaccine effectiveness (VE) and other preventive measures to halt the pandemic. A test-negative case–control study was conducted among adults (age ≥18 years) who were at-risk for COVID-19 and presented for nasopharyngeal real-time polymerase chain reaction testing during the Omicron variant-dominant period in Thailand (1 January 2022–15 June 2022). All participants were prospectively followed up for COVID-19 development for 14 days after the enrolment. Vaccine effectiveness was estimated and adjusted for characteristics associated with COVID-19. Of the 7971 included individuals, there were 3104 cases and 4867 controls. The adjusted VE among persons receiving 2-dose, 3-dose, and 4-dose vaccine regimens for preventing infection and preventing moderate-to-critical diseases were 33%, 48%, 62% and 60%, 74%, 76%, respectively. The VE were generally higher among those receiving the last dose of vaccine within 90 days compared to those receiving the last dose more than 90 days prior to the enrolment. The highest VE were observed in individuals receiving the 4-dose regimen, CoronaVac-CoronaVac-ChAdOx1 nCoV-19-BNT162b2 for both preventing infection (65%) and preventing moderate-to-critical diseases (82%). Our study demonstrated increased VE along with an increase in number of vaccine doses received. Current vaccination programmes should focus on reducing COVID-19 severity and mandate at least one booster dose. The heterologous boosters with viral vector and mRNA vaccines were highly effective and can be used in individuals who previously received the primary series of inactivated vaccine.

Published
2023
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3. Comparing real-life effectiveness of various COVID-19 vaccine regimens during the delta variant-dominant pandemic: a test-negative case-control study

Author

Paskorn Sritipsukho, Thana Khawcharoenporn, Boonying Siribumrungwong, Pansachee Damronglerd, Nuntra Suwantarat, Araya Satdhabudha, Chanapai Chaiyakulsil, Phakatip Sinlapamongkolkul, Auchara Tangsathapornpong, Pornumpa Bunjoungmanee, Sira Nanthapisal, Chamnan Tanprasertkul, Naiyana Sritipsukho, Chatchai Mingmalairak, Anucha Apisarnthanarak, and Pichaya Tantiyavarong

Subjects
covid-19, real-life, vaccine, effectiveness, delta variant, thailand, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Data on real-life vaccine effectiveness (VE), against the delta variant (B.1.617.2) of the severe acute respiratory syndrome coronavirus 2 among various coronavirus disease 2019 (COVID-19) vaccine regimens are urgently needed to impede the COVID-19 pandemic. We conducted a test-negative case-control study to assess the VE of various vaccine regimens for preventing COVID-19 during the period when the delta variant was the dominant causative virus (≥ 95%) in Thailand (25 July 2021–23 Oct 2021). All individuals (age ≥18 years) at-risk for COVID-19, presented for nasopharyngeal real-time polymerase chain reaction (RT-PCR) testing, were prospectively enrolled and followed up for disease development. Vaccine effectiveness was estimated with adjustment for individual demographic and clinical characteristics. Of 3353 included individuals, there were 1118 cases and 2235 controls. The adjusted VE among persons receiving two-dose CoronaVac plus one BNT162b2 booster was highest (98%; 95% confidence interval [CI] 87–100), followed by those receiving two-dose CoronaVac plus one ChAdOx1 nCoV-19 booster (86%; 95% CI 74–93), two-dose ChAdOx1 nCoV-19 (83%; 95% CI 70–90), one CoronaVac dose and one ChAdOx1 nCoV-19 dose (74%; 95% CI 43–88) and two-dose CoronaVac (60%; 95% CI 49–69). One dose of CoronaVac or ChAdOx1 nCoV-19 had a VE of less than 50%. Our study demonstrated the incremental VE with the increase in the number of vaccine doses received. The two-dose CoronaVac plus one BNT162b2 or ChAdOx1 nCoV-19 booster regimens was highly effective in preventing COVID-19 during the rise of delta variant.

Published
2022
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4. Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)

Author

Nantanit Sutthiruk, Mari Botti, Julie Considine, Andrea Driscoll, Ana Hutchinson, Kumthorn Malathum, Cucunawangsih Cucunawangsih, Veronica Wiwing, Vivien Puspitasari, Rathina Kumar Shanmugakani, Yukihiro Akeda, Takuya Kodera, Pitak Santanirand, Kazunori Tomono, Takayuki Yamanaka, Hiroyuki Moriuchi, Hiroyuki Kitajima, Yuho Horikoshi, Alyona Lavrinenko, Ilya Azizov, Nurlan Tabriz, Margulan Kozhamuratov, Yekatherine Serbo, Dahae Yang, Woonhyoung Lee, Il Kwon Bae, Jae Hyun Lee, Hyukmin Lee, Jung Ok Kim, Seok Hoon Jeong, Kyungwon Lee, Thiba Peremalo, Priya Madhavan, Sharina Hamzah, Leslie Than, Eng Hwa Wong, Mohd Nasir Mohd Desa, Kee Peng Ng, Marionne Geronimo, Maria Fe Tayzon, Maria Jesusa Maño, Angela Chow, Pei-Yun Hon, Mar-Kyaw Win, Brenda Ang, Yee-Sin Leo, Tina See, Rocio Alvarez Marin, Marta Aires de Sousa, Nicolas Kieffer, Patrice Nordmann, Laurent Poirel, Wison Laochareonsuk, Sireekul Petyu, Pawin Wanasitchaiwat, Sutasinee Thana, Chollathip Bunyaphongphan, Woranan Boonsomsuk, Pakpoom Maneepongpermpoon, Silom Jamulitrat, Dorairajan Sureshkumar, Kalyanaraman Supraja, Soundararajan Sharmila, Benny Setiawan, Nicolaski Lumbuun, Haruo Nakayama, Toshiko Ota, Naoko Shirane, Chikako Matuoka, Kentaro Kodama, Masanobu Ohtsuka, Silverose Ann Andales Bacolcol, Melecia Velmonte, Allan Alde, Keithleen Chavez, Arlene Joy Esteban, Aisa Jensen Lee, Tai-Chin Hsieh, Shio-ShinJean, Huey-Jen Huang, Shu-Ju Huang, Yu-Huan Huang, Pei-Chen Cheng, Su-Fang Yu, Shih-Ming Tsao, Yuan-Ti Lee, Chien-Feng Li, Min-Chi Lu, Nattapol Pruetpongpun, Thana Khawcharoenporn, Pansachee Damronglerd, Nuntra Suwantarat, Anucha Apisarnthanarak, Sasinuch Rutjanawech, Lisa Cushinotto, Patty McBride, Harding Williams, Hans Liu, Phan Thi Hang, Dinh Pham Phuong Anh, Ngai Le, Dung Khu, Lam Nguyen, Roel Beltran Castillo, Ram Gopalakrishnan, Venkatasubramanian Ramasubramanian, Subramanian Sreevidya, Ranganathan Jayapradha, Atsushi Umetsu, Tetsuhiro Noda, Kenyuu Hashimoto, Akihiro Hayashi, Mikie Kabashima, Ursula Jadczak, Knut Elvelund, Marit Johnsen, Bente Borgen, Egil Lingaas, Chia-Hua Mao, Fu-Chieh Chang, Chang-Pan Liu, Ru-Hui Chao, Fu-chieh Chang, Chang-pan Liu, Junpen Pawapotako, Chadanan Prasertpan, Wantanee Malaihuan, Phisit Uirungroj, Chalermpong Saenjum, Teerapat Ouirungrog, Sue Borrell, Pauline Bass, Leon Worth, Zhao Xian-li, Li Xiao-long, Yao Xue-hua, Ren Wei, Zhang Xia Zeng, Man Ying Kong, Christopher Koon Chi Lai, Suet Yi Lee, Ngai Chong Tsang, M. M. O’Donoghue, M. V. Boost, L. K. P. Suen, G. K. Siu, K. W. Mui, C. K. C. Lai, D. N. C. Tsang, Yuka Sato, Mariko Tateishi, Mutsuko Mihashi, Jose Paulo Flor, Marko Bautista, V. Jay De Roxas, Justine Vergara, Nicolo Andrei Añonuevo, Marion Kwek, Jose Acuin, Anna Josea Sanchez, Avel Bathan, Jamilah Binte Jantan, Chua Chor Guek, Eu Chiow Kian, Pampe Anak Pirido, Nur Fadilah Binte Mohd Aron, Leah May Estacio, Francis Alvarez Palana, Michelle Gracia, Nur Syafiqah Binte Shamsuddin, Kersten Timbad Castro, Madonna Baloria, Faezah Binte Adam, Zhang Wei, Poh Bee Fong, Marimuthu Kalisvar, I-Ju Chuang, Yi-ChunCho, Yu-Fen Chiu, Lung-Chih Chen, Yi-Chun Lin, Shao-Xing Dong, Yi-Chieh Lee, Hui-Chen Kuan, Hsin-Hua Lin, Chia-Chun Chi, Chin-Te Lu, Tang Ya-Fen, Su Li-Hsiang, Liu Jien-Wei, Hsuehlan Chao, PinRu ChangChien, WeiFang Chen, ChungHsu Lai, Lutfe Ara, Syed Mohammad Niaz Mowla, Shaikh Mahmud Kamal Vashkar, Wai Fong Chan, Mabel Yin ChunYau, Karen Kam LingChong, Tze OnLi, Rajwinder Kaur, Ng Po Yan, Gloria Chor Shan Chiu, Christina W. Y. Cheung, Patricia T. Y. Ching, Radley H. C. Ching, Conita H. S. Lam, C. H. Kan, Shirley S. Y. Lee, C. P. Chen, Regina F. Y. Chan, Annie F. Y. Leung, Isadora L. C. Wong, S. S. Lam, Queenie W. L. Chan, Cecilia Chan, Seyed Sadeq Seyed Nematian, Charles John Palenik, Mehrdad Askarian, Nahid Hatam, Itaru Nakamura, Hiroaki Fujita, Ayaka Tsukimori, Takehito Kobayashi, Akihiro Sato, Shinji Fukushima, Tetsuya Matsumoto, V. James De Roxas, V James De Roxas, Nicolo AndreiAñonuevo, Yeng May Ho, Jia Qi Kum, Bee Fong Poh, Kalisvar Marimuthu, Tzu-Yin Liu, Sin-Man Chu, Hui-Zhu Chen, Tun-chieh Chen, Yichun Chen, Ya-Ching Tsao, Sumawadee Skuntaniyom, Pirawadee Tipluy, Sangwan Paengta, Ratchanee wongsaen, Sutthiphun thanomphan, Samettanet Tariyo, Buachan Thongchuea, Pattama Khamfu, Sutthiphan Thanomphan, Wipaporn Natalie Songtaweesin, Suvaporn Anugulruengkit, Rujipat Samransamruajkit, Darintr Sosothikul, Ornanong Tansrijitdee, Anry Nakphunsung, Patchareeyawan Srimuan, Jirachaya Sophonphan, ThanyaweePuthanakit, Kunyanut Payuk, Wilawan Picheansathian, Nongkran Viseskul, Elizabeth DeNardo, Rachel Leslie, Todd Cartner, Luciana Barbosa, Heinz-Peter Werner, Florian H. H. Brill, Julia Yaeko Kawagoe, Elizabeth De Nardo, Sarah Edmonds- Wilson, David Macinga, Patricia Mays-Suko, Collette Duley, Tran Thi Thuy Hang, Tran Thi My Hanh, Christopher Gordon, Roopa Durairaj, Anusha Rohit, Saujanya Saravanakumar, Jothymani Hemalatha, Ryuichi Hirano, Yuichi Sakamoto, Shoji Yamamoto, Naoki Tachibana, Miho Miura, Fumiyo Hieda, Yoshiro Sakai, Hiroshi Watanabe, Silverose Ann Bacolcol, Keitleen Chavez, Jia-Wei Lim, Aung-Aung Hein, Grace Tin, Vanessa Lim, Huwi-chun Chao, Chiu-Yin Yeh, Mei-feng Lo, Chonlada Piwpong, Songyos Rajborirug, Ploypailin Preechawetchakul, Yada Pruekrattananapa, Tharntip Sangsuwan, Ratchanee Wongsaen, Sungwan Paengta, Napatnun Nilchon, Sutthipun Thanompan, Samattanet Tariyo, Svetlana Kolesnichenko, Yerbol Tishkambayev, Asylkhan Alibecov, Yekaterina Serbo, Youngwon Nam, Jae Hyeon Park, Yun Ji Hong, Taek Soo Kim, Jeong Su Park, Kyoung Un Park, Eui-Chong Kim, Samuel Abumhere Aziegbemhin, Onaiwu Enabulele, Yao-Shen Tung, An-Chi Chen, Shen-Min Huang, Yui-Yein Yang, Li-Hung Wu, Chin-cheng Lin, Tzu Hao Lien, Jia Hao Chang, Yu Shan Huang, Yi Shun Chen, Sasithorn Sirilun, Phisit Ouirungroj, Suwanna Trakulsomboon, Patcharee Prasajak, Maryanne W. N. Kwok, Lady S. H. Ng, Lindy M. T. Wong, Lenina S. L. Poon, Mary K. L. Lai, Holly H. S. Cheng, S. K. Fong, Cindy F. Y. Leung, Jumpei Hasegawa, Hiroki Shirakawa, Sachiko Wakai, Makiko Mieno, Shuji Hatakeyama, Manu Deeudom, Prasit Tharavichitkul, Terrence Chinniah, Jackson Tan, Kavitha Prabu, Sartaj Alam, Aung Kyaw Wynn, Rashidah Ahmad, Amalina Sidek, Dg Azizah Samsuddin, Noraini Ajis, Aliyah Ahmad, Susylawathi Magon, Boon Chu, Jiqiu Kuang, Yan Gao, Shoujun Wang, Yunxiao Hao, Rong Liu, Dongmei Li, Hui Wang, Hisanori Nishio, Hitomi Mori, Yoshiko Morokuma, Takaaki Yamada, Makiko Kiyosuke, Sachie Yasunaga, Kazuhiro Toyoda, Nobuyuki Shimono, Dmitriy Babenko, Anar Turmuhambetova, Antonella Cheşcă, Mark A. Toleman, Lyudmila L. Akhmaltdinova, Mark Albert Magsakay, Angelo Macatibag, Jeannica Kriselle Lerios, Alyona Lavrineko, Dmitry Babenko, Eugene Sheck, Mikhail Edelstein, Lih-Yue Li, Chiung-Wen Chan, Hui-Chuan Pan, Wipa Vanishakije, Warisra Jaikampun, Su-Yin Li, Jian-Feng Li, Yu-Ping Wu, Chiao-Hui Lin, Ping-Chin Chang, Samatanet Tariyo, Suttsiphan Thanompan, Suchada Sukkra, Khalequ Zaman, Sheikh Farzana Zaman, Farzana Zaman, Asma Aziz, Sayeed-Bin Faisal, Magali Traskine, Javier Ruiz-Guiñazú, Dorota Borys, Wendy Wai Yee Lam, May Chow, Lucy Choy, Joseph Kam, Sharifah Azura Salleh, Razila Yacob, Siti Rokiah Yusof, Nordiah Awang Jalil, Maria Lourdes Millan, Jose Lito Acuin, Melecia A. Velmonte, Silverose Ann A. Bacolcol, Ching-I Ting, Sunisa Dissayasriroj, Terrence Rohan Chinniah, Jauharatud DiniSuhaimi, Aizzuddin Mirasin, Nurul Morni, Azizah Samsuddin, Amalina AbuBakar, Amanie Shafiee, Julaini Safar, Leung Annie, Fung Yuk Ling, Lau Edna, Luk Kristine, Satoshi Shinomiya, Kumiko Yamamoto, Kayoko Kjiwara, Mitsuhiro Yamaguchi, Wei Zhang, Bee-Fong Poh, Ming-Chin Chan, Chih-Chien Wang, Huan-Yu Huang, Chiung-Ling Lai, Sajeerat Kosol, Wantana Sakolwirat, Patchanee Paepong, Sawalee Jansanga, Pattarin Jaisamoot, Nuttha Thongnuanual, Chittima Srithong, Somporn Somsakul, Sutima Plongpunth, Mukkapon Punpop, Porntip Malathum, Kulada Peautiwat, Nattawipa boon kirdram, Pimpaporn Klunklin, Geetha Samethadka, Naoko Suzuki, Hitomi Asada, Masao Katayama, Atsushi Komano, Hidehiro Watanabe, Hye Kyung Seo, Joo-Hee Hwang, Myoung Jin Shin, Su Young Kim, Eu Suk Kim, Kyoung-Ho Song, Hong Bin Kim, Lai-Si Un, Choi-Ian Vong, Jocelyn Koh, Sherly Agustinus, Rozita Bte Abu Hassan, Yin Phyu Thinn, Benjamin Ng, Soe Pyae Tun, Su Mon Thi Ha, Xue Xiaoting, Lin Li, Leyland Chuang, Attanayaka Mudiyanselage Chulani Niroshika, Kaluarachchige Anoma Kaluarachchi Perera, Dimingo Kankanamalage Diana Grace Fernando, Bodhipakshage Rohini Hemamala, Chiu-yin Yeh, Hui-Chun Yang, Hsiang-Ju Chiu, Ya-Ling Shih, Yu-Shan Chien, Wan-Yi Lin, Chia-Yun Pan, Ying-Yun Chang, Chiu-Yuch Yea, Ming-Hsien Chu, Li-Chu Lee, Lin Yu-Hsiu, Guo Siao-Pei, Leung Pak-On, Sie Mei-Fe, Chen Jyh-Jou, Chang Yong-Yuan, Shu-Yuan Kuo, Yu-Hsiu Lin, Ji-Sheng Zhang, Pak-On Leung, Mei-Fe Sie, Jyh-Jou Chen, Yan-Ru Chen, Ying-Ling Chen, Chi-Fen Taou, Hsiao-Shan Chen, Hung-Jen Tang, Shin Yu Chen, Yin Yin Chen, Fu Der Wang, Tzu-Ping Shih, Chin-Yu Chen, Su-Jung Chen, Mei-chi Wu, Wan-ju Yang, Mei-ling Chou, Man-Ling Yu, Li-Chu Li, Cheng-Wei Chu, Wen-Hao Tsou, Wen-Chih Wu, Wen-Chi Cheng, Cho-Ching Sun, Shu-Hua Lu, Hsin-Ling Yang, Cheng-Yu Lu, Nitchawan Hirunprapakorn, Sirilux Apivanich, Ttipakorn Pornmee, Chonnikarnt Beowsomboon, Itthaporn Kumkoom, Nongyao Kasatpibal, Jittaporn Chitreecheur, JoAnne D. Whitney, Surasak Saokaew, Kirati Kengkla, Margaret M. Heitkemper, Thanomvong Muntajit, Siriluk Apivanich, Hang Thi Phan, Anh Pham Phuong Dinh, and Tuyet Thi Kim Nguyen

Subjects
Infectious and parasitic diseases, RC109-216
Published
2017
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5. Nocardia intracranial mycotic aneurysm associated with proteasome inhibitor

Author

Siriththin Chansirikarnjana, Anucha Apisarnthanarak, Nuntra Suwantarat, Pansachee Damronglerd, Sasinuch Rutjanawech, Suttichai Visuttichaikit, and Thana Khawcharoenporn

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

We report a case of Nocardia farcinica ruptured intracranial mycotic aneurysm associated with bortezomib and corticosteroid treatment in a multiple myeloma patient. The patient was treated with trimethoprim-sulfamethoxazole and moxifloxacin together with surgical repairment of intracranial mycotic aneurysm. Keywords: Nocardia, Nocardia farcinica, Mycotic aneurysm, Multiple myeloma, Proteasome inhibitor

Published
2019
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6. Enhanced inpatient rounds, appointment reminders, and patient education improved HIV care engagement following hospital discharge

Author

Thana Khawcharoenporn, Pansachee Damronglerd, Krongtip Chunloy, and Beverly E. Sha

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Anti-HIV Agents, Reminder Systems, Human immunodeficiency virus (HIV), HIV Infections, Dermatology, medicine.disease_cause, Appointments and Schedules, 03 medical and health sciences, 0302 clinical medicine, Patient Education as Topic, medicine, Hospital discharge, Humans, Pharmacology (medical), 030212 general & internal medicine, business.industry, Public Health, Environmental and Occupational Health, Continuity of Patient Care, Middle Aged, Thailand, 030112 virology, Patient Discharge, Infectious Diseases, Emergency medicine, Patient Compliance, Female, business, Patient education
Abstract

Human immunodeficiency virus (HIV) care engagement post hospital discharge is often suboptimal. Strategies to improve follow-up are needed. A quasi-experimental study was conducted among hospitalized HIV-infected patients between the period from 1 January 2013 to 30 June 2014 (preintervention period) and 1 July 2014 to 31 December 2015 (intervention period). During the intervention period, an HIV care team consisting of an Infectious Diseases physician, a nurse, a pharmacist, a social worker, and an HIV-infected volunteer made daily inpatient rounds. Prior to discharge, patients received a structured HIV education session and an outpatient appointment was scheduled for them with two telephone reminder calls following discharge. There were 240 HIV-infected patients enrolled (120 in each study period), of which the median age was 37 years (interquartile range [IQR] 28–44 years), 58% were male, 39% were newly diagnosed with HIV infection, 46% were hospitalized because of AIDS-related conditions, and the median CD4 cell count on admission was 158 cells/µl (IQR 72–382 cells/µl). The rate of HIV care engagement within 30 days after discharge was significantly higher in the intervention period compared to the preintervention period (95% versus 69%; P ClinicalTrials.gov Identifier: NCT02578654

Published
2018
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7. Inappropriate Empirical Treatment of Uncomplicated Cystitis in Thai Women: Lessons Learned

Author

Nattapol Pruetpongpun, Pansachee Damronglerd, Thana Khawcharoenporn, Anucha Apisarnthanarak, Sasinuch Rutjanawech, and Nuntra Suwantarat

Subjects
Adult, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Surveillance data, Adolescent, 030106 microbiology, Inappropriate Prescribing, Microbial Sensitivity Tests, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Cystitis, Drug Resistance, Bacterial, Escherichia coli, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Antibiotic use, Intensive care medicine, Prospective cohort study, business.industry, Enterobacteriaceae Infections, Middle Aged, Staphylococcal Infections, Thailand, Hospital care, Fluoroquinolone resistance, Anti-Bacterial Agents, Empirical treatment, Infectious Diseases, Female, Thai women, business, Fluoroquinolones
Abstract

A prospective study conducted in a Thai general practice clinic demonstrated a high prevalence (91.3%) of inappropriate empirical antibiotic use in women with uncomplicated cystitis and 42.6% Escherichia coli fluoroquinolone resistance. An annual update of antimicrobial resistance surveillance data of uropathogens may permit targeted treatment of patients in hospital care.

Published
2017
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8. A case of secondary syphilis with pulmonary involvement and review of the literature

Author

Suttichai Visuttichaikit, Anucha Apisarnthanarak, Nuntra Suwantarat, and Pansachee Damronglerd

Subjects
Adult, Male, medicine.medical_specialty, Chest Pain, Percutaneous, Lung abscess, HIV Infections, Dermatology, Secondary syphilis, Amoxicillin-Potassium Clavulanate Combination, Polymerase Chain Reaction, 03 medical and health sciences, 0302 clinical medicine, Benzathine penicillin g, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Lung Abscess, Syphilis, Treponema pallidum, Lung, Treponema, biology, business.industry, Public Health, Environmental and Occupational Health, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, Syphilis Serodiagnosis, Infectious Diseases, Treatment Outcome, Fluid specimen, 030220 oncology & carcinogenesis, Penicillin G Benzathine, business, Tomography, X-Ray Computed, After treatment
Abstract

Syphilis is a sexually transmitted systemic infection caused by Treponema pallidum. We report a case of a heterosexual, HIV-positive man who presented with secondary syphilis and a lung abscess. A bacterial lung abscess was suspected and a computed tomography-guided percutaneous needle aspiration of the lung abscess was performed. Direct pulmonary involvement by T. pallidum was suggested by a positive PCR result on the aspirated fluid specimen. The clinical signs of secondary syphilis improved, and the lung abscess was resolved after treatment with benzathine penicillin G and amoxicillin-clavulanate. The final diagnosis was secondary pulmonary syphilis. Few reports of secondary syphilis with pulmonary involvement have been reported to date.

Published
2018

9. Photo Quiz: An 88-Year-Old Immunosuppressed Thai Man with Diarrhea, Septic Shock, and Rashes

Author

Nattapol Pruetpongpun, Sasinuch Rujanavej, Anucha Apisarnthanarak, William Michael Dunne, Worapop Suthiwartnarueput, Pansachee Damronglerd, and Thana Khawcharoenporn

Subjects
Microbiology (medical), medicine.medical_specialty, Pediatrics, Septic shock, business.industry, Vital signs, Photo Quiz, Azathioprine, medicine.disease, Surgery, Diarrhea, medicine, Prednisolone, medicine.symptom, Autoimmune hemolytic anemia, Watery diarrhea, business, medicine.drug
Abstract

An 88-year-old Thai man with recently diagnosed autoimmune hemolytic anemia (AIHA) was started on prednisolone at 40 mg/day and azathioprine at 50 mg/day 2 weeks prior to admission. He presented with watery diarrhea, a low-grade fever, and fatigue that had started 1 week prior. His vital signs

Published
2017

10. The Brief Case: Central Nervous System Sparganosis in a 53-Year-Old Thai Man

Author

Aubonphan Buppajarntham, Abigail L. Carlson, Pansachee Damronglerd, Neil W. Anderson, Nattapol Pruetpongpun, and Anucha Apisarnthanarak

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, Gabapentin, business.industry, The Brief Case, Sparganosis, 030231 tropical medicine, Pemphigus vulgaris, Central nervous system, Anatomy, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Back pain, medicine, Prednisolone, Amitriptyline, Tramadol, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

A 53-year-old Thai man with a history of pemphigus vulgaris on chronic prednisolone (30 mg/day) presented to a hospital in Thailand with a 5-month history of lower back pain. He had initially been treated with tramadol, amitriptyline, and gabapentin without relief. Two months prior to presentation

Published
2017

12. Nocardia intracranial mycotic aneurysm associated with proteasome inhibitor

Author

Nuntra Suwantarat, Siriththin Chansirikarnjana, Thana Khawcharoenporn, Pansachee Damronglerd, Sasinuch Rutjanawech, Anucha Apisarnthanarak, and Suttichai Visuttichaikit

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Nocardia farcinica, 030106 microbiology, Corticosteroid treatment, Infectious and parasitic diseases, RC109-216, Article, Nocardia, Mycotic aneurysm, 03 medical and health sciences, 0302 clinical medicine, Multiple myeloma, immune system diseases, Moxifloxacin, hemic and lymphatic diseases, medicine, Proteasome inhibitor, cardiovascular diseases, 030212 general & internal medicine, biology, business.industry, Bortezomib, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Infectious Diseases, cardiovascular system, business, medicine.drug
Abstract

We report a case of Nocardia farcinica ruptured intracranial mycotic aneurysm associated with bortezomib and corticosteroid treatment in a multiple myeloma patient. The patient was treated with trimethoprim-sulfamethoxazole and moxifloxacin together with surgical repairment of intracranial mycotic aneurysm. Keywords: Nocardia, Nocardia farcinica, Mycotic aneurysm, Multiple myeloma, Proteasome inhibitor

Published
2019
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13. Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-γ Autoantibodies

Author

Anucha Apisarnthanarak, Worapop Suthiwartnarueput, Nattapol Pruetpongpun, Nuntra Suwantarat, Pansachee Damronglerd, Thana Khawcharoenporn, and Sasinuch Rujanavej

Subjects
anti-interferon-γ autoantibody, 0301 basic medicine, Talaromyces, 030106 microbiology, Mycobacterium abscessus, 03 medical and health sciences, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Immunodeficiency, disseminated penicilliosis, biology, business.industry, Intracellular parasite, Talaromyces marneffei, Autoantibody, biology.organism_classification, medicine.disease, Antimicrobial, Virology, Infectious Diseases, Oncology, Immunology, Brief Reports, Rituximab, Penicillium marneffei, business, medicine.drug
Abstract

Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successfully treated with antimicrobial therapy and rituximab to control B cell-derived autoantibodies.

Published
2016
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14. Answer to March 2017 Photo Quiz

Author

Thana Khawcharoenporn, Anucha Apisarnthanarak, Nattapol Pruetpongpun, Sasinuch Rujanavej, Worapop Suthiwartnarueput, William Michael Dunne, and Pansachee Damronglerd

Subjects
Microbiology (medical), medicine.medical_specialty, animal structures, genetic structures, Rhabditiform larvae, business.industry, fungi, Cutaneous strongyloidiasis, Photo Quiz, Stool examination, Dermatology, Disseminated strongyloidiasis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Medicine, Sputum, 030212 general & internal medicine, medicine.symptom, Larva migrans, business, human activities
Abstract

Answer: Disseminated strongyloidiasis presenting with larva migrans or cutaneous strongyloidiasis. A repeated stool examination for ova and parasites revealed a few typical rhabditiform larvae (not shown); examination of a fresh sputum smear revealed no larvae. On hospital day 6, the patient

Published
2017
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15. Impact of Physicians’ Mindfulness Attitudes toward Prevention of Catheter-Associated Urinary Tract Infection

Author

Thana Khawcharoenporn, Anucha Apisarnthanarak, Sasinuj Rutjanawech, Pansachee Damronglerd, and Atibordee Meesing

Subjects
Microbiology (medical), medicine.medical_specialty, Infectious Diseases, Mindfulness, Epidemiology, business.industry, MEDLINE, medicine, Retrospective cohort study, Intensive care medicine, business, Catheter-associated urinary tract infection
Published
2014
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16. A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot study

Author

Sasisopin Kiertiburanakul, Pansachee Damronglerd, Apichaya Puangpetch, Chonlaphat Sukasem, and Wilawan Thipmontree

Subjects
medicine.medical_specialty, Efavirenz, CYP2B6, Pharmacology, law.invention, chemistry.chemical_compound, Pharmacogenomics and Personalized Medicine, Randomized controlled trial, law, Dose adjustment, Internal medicine, Hiv infected, medicine, Prospective cohort study, Original Research, pharmacogenetics, business.industry, virus diseases, efavirenz, chemistry, Pharmacogenomics, HIV-infected patient, Molecular Medicine, CYP2B6 polymorphism, Thai, business, Pharmacogenetics, prospective study
Abstract

Pansachee Damronglerd,1 Chonlaphat Sukasem,2,4 Wilawan Thipmontree,3 Apichaya Puangpetch,2,4 Sasisopin Kiertiburanakul1 1Deparment of Medicine, 2Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 3Department of Medicine, Faculty of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, 4Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Objective: We aimed at comparing clinical/immunological outcomes in human immunodeficiency virus (HIV)-infected patients who were treated with CYP2B6-guided and conventional efavirenz (EFV) therapy. Methods: This study was a 24-week prospective randomized controlled trial. Eligible patients were HIV-infected adults yet to start antiretroviral therapy. Twenty-four HIV-infected patients were recruited and randomly assigned to genotype CYP2B6 polymorphism before ART initial dose. Patients with CYP2B6 *6/*6 received 400 mg EFV-based regimen and those with other genotypes received 600 mg EFV-based therapy. Results: For CYP2B6 polymorphism, 12 patients were extensive metabolizers, ten patients were intermediate metabolizers, and only two patients were poor metabolizers (*6/*6). The overall mean EFV plasma concentrations were similar in both groups. The mean drug concentrations (standard deviation) were 1.675 (0.963), 1.445 (0.778), and 1.899 (0.808) µg/mL at week 4, 12, and 24, respectively. The CYP2B6 *6/*6 patient who received low dose of EFV had lower mean EFV level than those who received a normal dose, 1.916 versus 3.915 µg/mL (P

Published
2015
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17. A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among hiV-infected Thai patients: a pilot study.

Author

Pansachee Damronglerd, Chonlaphat Sukasem, Wilawan Thipmontree, Apichaya Puangpetch, and Sasisopin Kiertiburanakul

Subjects
EFAVIRENZ, ANTI-HIV agents, REVERSE transcriptase inhibitors, PATIENT compliance, PILOT projects, MEDICAL care
Abstract

Objective: We aimed at comparing clinical/immunological outcomes in human immunodei- ciency virus (HIV)-infected patients who were treated with CYP2B6-guided and conventional efavirenz (EFV) therapy. Methods: This study was a 24-week prospective randomized controlled trial. Eligible patients were HIV-infected adults yet to start antiretroviral therapy. Twenty-four HIV-infected patients were recruited and randomly assigned to genotype CYP2B6 polymorphism before ART initial dose. Patients with CYP2B6 *6/*6 received 400 mg EFV-based regimen and those with other genotypes received 600 mg EFV-based therapy. Results: For CYP2B6 polymorphism, 12 patients were extensive metabolizers, ten patients were intermediate metabolizers, and only two patients were poor metabolizers (*6/*6). The overall mean EFV plasma concentrations were similar in both groups. The mean drug concentrations (standard deviation) were 1.675 (0.963), 1.445 (0.778), and 1.899 (0.808) µg/mL at week 4, 12, and 24, respectively. The CYP2B6 *6/*6 patient who received low dose of EFV had lower mean EFV level than those who received a normal dose, 1.916 versus 3.915 µg/mL (P,0.001), respectively. Seventy percent of the patients had neuropsychiatric adverse events, especially dizziness. Discussion: There was a trend toward association of the CYP2B6 polymorphism and plasma EFV concentrations in this study. Reduced EFV dose should be considered in CYPB6 *6/*6 carrier to keep the drug concentration in therapeutic range. [ABSTRACT FROM AUTHOR]

Published
2015
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