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23 results on '"Panowski, Siler H."'

1. Constitutive Turbodomains enhance expansion and antitumor activity of allogeneic BCMA CAR T cells in preclinical models

Author

Lin, Regina J., primary, Sutton, Janette, additional, Bentley, Trevor, additional, Vargas-Inchaustegui, Diego A., additional, Nguyen, Duy, additional, Cheng, Hsin-Yuan, additional, Yoon, Hayung, additional, Van Blarcom, Thomas J., additional, Sasu, Barbra J., additional, Panowski, Siler H., additional, and Sommer, Cesar, additional

Published
2023
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2. Supplementary Table from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Author

Panowski, Siler H., primary, Srinivasan, Surabhi, primary, Tan, Nguyen, primary, Tacheva-Grigorova, Silvia K., primary, Smith, Bryan, primary, Mak, Yvonne S.L., primary, Ning, Hongxiu, primary, Villanueva, Jonathan, primary, Wijewarnasuriya, Dinali, primary, Lang, Shanshan, primary, Melton, Zea, primary, Ghosh, Adit, primary, Dusseaux, Mathilde, primary, Galetto, Roman, primary, Heyen, Jonathan R., primary, Sai, Tao, primary, Van Blarcom, Thomas, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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3. Supplementary Figure from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Author

Panowski, Siler H., primary, Srinivasan, Surabhi, primary, Tan, Nguyen, primary, Tacheva-Grigorova, Silvia K., primary, Smith, Bryan, primary, Mak, Yvonne S.L., primary, Ning, Hongxiu, primary, Villanueva, Jonathan, primary, Wijewarnasuriya, Dinali, primary, Lang, Shanshan, primary, Melton, Zea, primary, Ghosh, Adit, primary, Dusseaux, Mathilde, primary, Galetto, Roman, primary, Heyen, Jonathan R., primary, Sai, Tao, primary, Van Blarcom, Thomas, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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4. Data from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Author

Panowski, Siler H., primary, Srinivasan, Surabhi, primary, Tan, Nguyen, primary, Tacheva-Grigorova, Silvia K., primary, Smith, Bryan, primary, Mak, Yvonne S.L., primary, Ning, Hongxiu, primary, Villanueva, Jonathan, primary, Wijewarnasuriya, Dinali, primary, Lang, Shanshan, primary, Melton, Zea, primary, Ghosh, Adit, primary, Dusseaux, Mathilde, primary, Galetto, Roman, primary, Heyen, Jonathan R., primary, Sai, Tao, primary, Van Blarcom, Thomas, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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5. Supplementary Data from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Author

Panowski, Siler H., primary, Srinivasan, Surabhi, primary, Tan, Nguyen, primary, Tacheva-Grigorova, Silvia K., primary, Smith, Bryan, primary, Mak, Yvonne S.L., primary, Ning, Hongxiu, primary, Villanueva, Jonathan, primary, Wijewarnasuriya, Dinali, primary, Lang, Shanshan, primary, Melton, Zea, primary, Ghosh, Adit, primary, Dusseaux, Mathilde, primary, Galetto, Roman, primary, Heyen, Jonathan R., primary, Sai, Tao, primary, Van Blarcom, Thomas, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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6. Supplementary Data from Design and Validation of Inducible TurboCARs with Tunable Induction and Combinatorial Cytokine Signaling

Author

Lin, Regina J., primary, Nager, Andrew R., primary, Park, Spencer, primary, Sutton, Janette, primary, Lay, Cecilia, primary, Melton, Zea, primary, Zhang, Yi, primary, Boldajipour, Bijan, primary, Blarcom, Thomas J. Van, primary, Panowski, Siler H., primary, Sasu, Barbra J., primary, and Chaparro-Riggers, Javier, primary

Published
2023
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8. Figure S5 from Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Author

Panowski, Siler H., primary, Kuo, Tracy C., primary, Zhang, Yi, primary, Chen, Amy, primary, Geng, Tao, primary, Aschenbrenner, Laura, primary, Kamperschroer, Cris, primary, Pascua, Edward, primary, Chen, Wei, primary, Delaria, Kathy, primary, Farias, Santiago, primary, Bateman, Marjorie, primary, Dushin, Russell G., primary, Chin, Sherman M., primary, Van Blarcom, Thomas J., primary, Yeung, Yik Andy, primary, Lindquist, Kevin C., primary, Chunyk, Allison G., primary, Kuang, Bing, primary, Han, Bora, primary, Mirsky, Michael, primary, Pardo, Ingrid, primary, Buetow, Bernard, primary, Martin, Thomas G., primary, Wolf, Jeffrey L., primary, Shelton, David, primary, Rajpal, Arvind, primary, Strop, Pavel, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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9. Data from Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Author

Panowski, Siler H., primary, Kuo, Tracy C., primary, Zhang, Yi, primary, Chen, Amy, primary, Geng, Tao, primary, Aschenbrenner, Laura, primary, Kamperschroer, Cris, primary, Pascua, Edward, primary, Chen, Wei, primary, Delaria, Kathy, primary, Farias, Santiago, primary, Bateman, Marjorie, primary, Dushin, Russell G., primary, Chin, Sherman M., primary, Van Blarcom, Thomas J., primary, Yeung, Yik Andy, primary, Lindquist, Kevin C., primary, Chunyk, Allison G., primary, Kuang, Bing, primary, Han, Bora, primary, Mirsky, Michael, primary, Pardo, Ingrid, primary, Buetow, Bernard, primary, Martin, Thomas G., primary, Wolf, Jeffrey L., primary, Shelton, David, primary, Rajpal, Arvind, primary, Strop, Pavel, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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10. Tables and Methods from Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Author

Panowski, Siler H., primary, Kuo, Tracy C., primary, Zhang, Yi, primary, Chen, Amy, primary, Geng, Tao, primary, Aschenbrenner, Laura, primary, Kamperschroer, Cris, primary, Pascua, Edward, primary, Chen, Wei, primary, Delaria, Kathy, primary, Farias, Santiago, primary, Bateman, Marjorie, primary, Dushin, Russell G., primary, Chin, Sherman M., primary, Van Blarcom, Thomas J., primary, Yeung, Yik Andy, primary, Lindquist, Kevin C., primary, Chunyk, Allison G., primary, Kuang, Bing, primary, Han, Bora, primary, Mirsky, Michael, primary, Pardo, Ingrid, primary, Buetow, Bernard, primary, Martin, Thomas G., primary, Wolf, Jeffrey L., primary, Shelton, David, primary, Rajpal, Arvind, primary, Strop, Pavel, primary, Chaparro-Riggers, Javier, primary, and Sasu, Barbra J., primary

Published
2023
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14. Design and Validation of Inducible TurboCARs with Tunable Induction and Combinatorial Cytokine Signaling

Author

Lin, Regina J., primary, Nager, Andrew R., additional, Park, Spencer, additional, Sutton, Janette, additional, Lay, Cecilia, additional, Melton, Zea, additional, Zhang, Yi, additional, Boldajipour, Bijan, additional, Blarcom, Thomas J. Van, additional, Panowski, Siler H., additional, Sasu, Barbra J., additional, and Chaparro-Riggers, Javier, additional

Published
2022
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15. Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Author

Panowski, Siler H., primary, Srinivasan, Surabhi, additional, Tan, Nguyen, additional, Tacheva-Grigorova, Silvia K., additional, Smith, Bryan, additional, Mak, Yvonne S.L., additional, Ning, Hongxiu, additional, Villanueva, Jonathan, additional, Wijewarnasuriya, Dinali, additional, Lang, Shanshan, additional, Melton, Zea, additional, Ghosh, Adit, additional, Dusseaux, Mathilde, additional, Galetto, Roman, additional, Heyen, Jonathan R., additional, Sai, Tao, additional, Van Blarcom, Thomas, additional, Chaparro-Riggers, Javier, additional, and Sasu, Barbra J., additional

Published
2022
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18. Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

Author

D'Angelo, Maximiliano A., Raices, Marcela, Panowski, Siler H., and Hetzer, Martin W.

Subjects
Proteins, Permeability, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2008.11.037 Byline: Maximiliano A. D'Angelo (1), Marcela Raices (1), Siler H. Panowski (1), Martin W. Hetzer (1) Keywords: CELLBIO; HUMDISEASE; DEVBIO Abstract: In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC components, like Nup153 and Nup50, are continuously exchanged, scaffold nucleoporins, like the Nup107/160 complex, are extremely long-lived and remain incorporated in the nuclear membrane during the entire cellular life span. Besides the lack of nucleoporin expression and NPC turnover, we discovered an age-related deterioration of NPCs, leading to an increase in nuclear permeability and the leaking of cytoplasmic proteins into the nucleus. Our finding that nuclear 'leakiness' is dramatically accelerated during aging and that a subset of nucleoporins is oxidatively damaged in old cells suggests that the accumulation of damage at the NPC might be a crucial aging event. Author Affiliation: (1) Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA Article History: Received 20 May 2008; Revised 5 October 2008; Accepted 21 November 2008 Article Note: (miscellaneous) Published: January 22, 2009

Published
2009

20. Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Author

Panowski, Siler H., primary, Kuo, Tracy C., additional, Zhang, Yi, additional, Chen, Amy, additional, Geng, Tao, additional, Aschenbrenner, Laura, additional, Kamperschroer, Cris, additional, Pascua, Edward, additional, Chen, Wei, additional, Delaria, Kathy, additional, Farias, Santiago, additional, Bateman, Marjorie, additional, Dushin, Russell G., additional, Chin, Sherman M., additional, Van Blarcom, Thomas J., additional, Yeung, Yik Andy, additional, Lindquist, Kevin C., additional, Chunyk, Allison G., additional, Kuang, Bing, additional, Han, Bora, additional, Mirsky, Michael, additional, Pardo, Ingrid, additional, Buetow, Bernard, additional, Martin, Thomas G., additional, Wolf, Jeffrey L., additional, Shelton, David, additional, Rajpal, Arvind, additional, Strop, Pavel, additional, Chaparro-Riggers, Javier, additional, and Sasu, Barbra J., additional

Published
2019
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22. Integrin-linked kinase modulates longevity and thermotolerance inC. elegansthrough neuronal control of HSF-1

Author

Kumsta, Caroline, primary, Ching, Tsui-Ting, additional, Nishimura, Mayuko, additional, Davis, Andrew E., additional, Gelino, Sara, additional, Catan, Hannah H., additional, Yu, Xiaokun, additional, Chu, Chu-Chiao, additional, Ong, Binnan, additional, Panowski, Siler H., additional, Baird, Nathan, additional, Bodmer, Rolf, additional, Hsu, Ao-Lin, additional, and Hansen, Malene, additional

Published
2014
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