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299 results on '"Pankuweit, S."'

24. Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations

Author

Cuenca S., Barriales-Villa R., Franaszczyk M., Coronado-Albi M.J., Rangel-Sousa D., Jiménez-Jáimez J., Ripoll-Vera T., Mogollón-Jiménez M.V., Fontalba-Romero A., Palomino-Doza J., Salas C., Hey T.M., Elliott P., Eiskjær H., Barriales R., Fernández Fernández X., Cicerchia M., Monserrat L., Ochoa J.P., Salazar-Mendiguchia J., Mogollón M.V., Ripoll T., Charron P., Richard P., Villard E., Palomino Doza J., Fontalba A., Alonso-Pulpón L., Cobo-Marcos M., Domínguez F., Garcia-Pavia P., Gómez-Bueno M., González-López E., Hernández-Hernández A., Hernández-Pérez F.J., López-Sainz Á., Restrepo-Córdoba A., Segovia-Cubero J., Toro R., de Gonzalo-Calvo D., Rosa Longobardo F., Limeres J., Rodriguez-Palomares J.F., Garcia-Pinilla J.M., López-Garrido M.A., Jiménez-Jaimez J., Garcia-Medina D., Rangel Sousa D., Peña M.L., Mogensen J., Morris-Hey T., Barton P.J., Cook S.A., Midwinter W., Roberts A.M., Ware J.S., Walsh R., Akhtar M., Elliott P.M., Rocha-Lopes L., Savvatis K., Syrris P., Michalak E., Ploski R., Sobieszczanska-Malek M., Bilinska Z., Pankuweit S., Asselbergs F., Baas A., Dooijes D., and Sammani A.

Subjects
Cardiomyopathy, Dilated, BAG3 protein, human, Adolescent, sex difference, electrocardiography, retrospective study, nonsense mutation, heart failure, signal transducing adaptor protein, protein localization, heart transplantation, Article, sudden cardiac death, BLC2 associated athanogene 3 gene, Cohort Studies, male, cardiovascular mortality, congestive cardiomyopathy, middle aged, follow up, chaperone, cardiovascular parameters, controlled study, genetics, human, gene mutation, penetrance, BAG3 protein, pathophysiology, Adaptor Proteins, Signal Transducing, Electroca, adult, apoptosis regulatory protein, clinical trial, cohort analysis, major clinical study, human tissue, unclassified drug, left ventricular enddiastolic diameter, multicenter study, female, priority journal, immunohistochemistry, young adult, prognosis, mutation, Apoptosis Regulatory Proteins, heart ventricle arrhythmia, heart left ventricle ejection fraction
Abstract

Background: The BAG3 (BLC2-associated athanogene 3) gene codes for an antiapoptotic protein located on the sarcomere Z-disc. Mutations in BAG3 are associated with dilated cardiomyopathy (DCM), but only a small number of cases have been reported to date, and the natural history of BAG3 cardiomyopathy is poorly understood. Objectives: This study sought to describe the phenotype and prognosis of BAG3 mutations in a large multicenter DCM cohort. Methods: The study cohort comprised 129 individuals with a BAG3 mutation (62% males, 35.1 ± 15.0 years of age) followed at 18 European centers. Localization of BAG3 in cardiac tissue was analyzed in patients with truncating BAG3 mutations using immunohistochemistry. Results: At first evaluation, 57.4% of patients had DCM. After a median follow-up of 38 months (interquartile range: 7 to 95 months), 68.4% of patients had DCM and 26.1% who were initially phenotype-negative developed DCM. Disease penetrance in individuals >40 years of age was 80% at last evaluation, and there was a trend towards an earlier onset of DCM in men (age 34.6 ± 13.2 years vs. 40.7 ± 12.2 years; p = 0.053). The incidence of adverse cardiac events (death, left ventricular assist device, heart transplantation, and sustained ventricular arrhythmia) was 5.1% per year among individuals with DCM. Male sex, decreased left ventricular ejection fraction. and increased left ventricular end-diastolic diameter were associated with adverse cardiac events. Myocardial tissue from patients with a BAG3 mutation showed myofibril disarray and a relocation of BAG3 protein in the sarcomeric Z-disc. Conclusions: DCM caused by mutations in BAG3 is characterized by high penetrance in carriers >40 years of age and a high risk of progressive heart failure. Male sex, decreased left ventricular ejection fraction, and enlarged left ventricular end-diastolic diameter are associated with adverse outcomes in patients with BAG3 mutations. © 2018 American College of Cardiology Foundation

Published
2018

26. P5450Evening levels and circadian changes of salivary cortisol predict adverse events in heart failure patients with comorbid depression - a MOOD-HF substudy

Author

Barthel, L, primary, Kroiss, M, additional, Sehner, S, additional, Lezius, S, additional, Gunold, H, additional, Edelmann, F, additional, Wachter, R, additional, Graf, T, additional, Pankuweit, S, additional, Knappe, D, additional, Stork, S, additional, Deckert, J, additional, Ertl, G, additional, Fassnacht, M, additional, and Angermann, C E, additional

Published
2019
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27. Pericardial effusion of HIV-infected patients - results of a prospective multicenter cohort study in the era of antiretroviral therapy

Author

Lind A, Reinsch N, Neuhaus K, Esser S, Brockmeyer N, Potthoff A, Pankuweit S, Erbel R, Maisch B, and Neumann T

Subjects
pericardial effusion, HIV-infection, AIDS, antiretroviral therapy, Medicine
Abstract

Abstract Background Patients with human immunodeficiency virus (HIV) infection have an increased risk of cardiovascular diseases. Previous publications described pericardial effusion as one of the most common HlV-associated cardiac affiliations. The aim of the current study was to investigate if pericardial effusion still has a relevant meaning of HIV-infected patients in the era of antiretroviral therapy. Methods The HIV-HEART (HIV-infection and HEART disease) study is a cardiology driven, prospective and multicenter cohort study. Outpatients with a known HIV-infection were recruited during a 20 month period in a consecutive manner from September 2004 to May 2006. The study comprehends classic parameters of HIV-infection, comprising CD4-cell count (cluster of differentiation) and virus load, as well as non-invasive tests of cardiac diseases, including a thorough transthoracic echocardiography. Results 802 HIV-infected patients (female: 16.6%) with a mean age of 44.2 ± 10.3 years, were included. Duration of HIV-infection since initial diagnosis was 7.6 ± 5.8 years. Of all participants, 85.2% received antiretroviral therapy. Virus load was detectable in 34.4% and CD4 - cell count was in 12.4% less than 200 cells/μL. Pericardial effusions were present in only two patients of the analysed population. None of the participants had signs of a relevant cardiovascular impairment by pericardial effusion. Conclusions Our results demonstrate that the era of antiretroviral therapy goes along with low rates of pericardial effusions in HIV-infected outpatients. Our findings are in contrast to the results of publications, performed before the common use of antiretroviral therapy.

Published
2011
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32. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Author

Caforio, ALIDA LINDA PATRIZIA, Pankuweit, S, Arbustini, E, Basso, Cristina, Gimeno Blanes, J, Felix, Sb, Fu, M, Heliö, T, Heymans, S, Jahns, R, Klingel, K, Linhart, A, Maisch, B, Mckenna, W, Mogensen, J, Pinto, Ym, Ristic, A, Schultheiss, Hp, Seggewiss, H, Tavazzi, L, Thiene, Gaetano, Yilmaz, A, Charron, P, Elliott, Pm, European Society of Cardiology Working Group on Myocardial, Pericardial, Diseases, Cardiologie, RS: CARIM School for Cardiovascular Diseases, ACS - Amsterdam Cardiovascular Sciences, and Cardiology

Subjects
Position statement, Diagnostic Imaging, medicine.medical_specialty, Viral Myocarditis, Myocarditis, Cardiomyopathy, Biopsy, Internal medicine, Idiopathic dilated cardiomyopathy, Diagnosis, Medicine, Humans, Referral and Consultation, business.industry, medicine.disease, Long-Term Care, Pericardial diseases, Diagnosis management, Etiology, Cardiology, Therapy, Cardiology and Cardiovascular Medicine, business, Biomarkers, Immunosuppressive Agents
Abstract

In this position statement of the ESC Working Group on Myocardial and Pericardial Diseases an expert consensus group reviews the current knowledge on clinical presentation, diagnosis and treatment of myocarditis, and proposes new diagnostic criteria for clinically suspected myocarditis and its distinct biopsy-proven pathogenetic forms. The aims are to bridge the gap between clinical and tissue-based diagnosis, to improve management and provide a common reference point for future registries and multicentre randomised controlled trials of aetiology-driven treatment in inflammatory heart muscle disease. ispartof: European Heart Journal vol:34 issue:33 pages:2636- ispartof: location:England status: published

Published
2013

37. Economic burden of chronic heart failure with preserved vs. reduced ejection fraction - an analysis from the German Competence Network Heart Failure

Author

Biermann, J, primary, Neumann, T, additional, Störk, S, additional, Stauffenberg, S, additional, Angermann, CE, additional, Düngen, HD, additional, Erbel, R, additional, Herzog, W, additional, Maisch, B, additional, Müller-Tasch, T, additional, Oezcelik, C, additional, Pankuweit, S, additional, Pieske, B, additional, Regitz-Zagrosek, V, additional, Scheffold, T, additional, Wachter, R, additional, Wasem, J, additional, and Neumann, A, additional

Published
2013
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39. Implementation of pharmacotherapy guidelines in heart failure: experience from the German Competence Network Heart Failure

Author

Zugck, C., primary, Franke, J., additional, Gelbrich, G., additional, Frankenstein, L., additional, Scheffold, T., additional, Pankuweit, S., additional, Duengen, H. D., additional, Regitz-Zagrosek, V., additional, Pieske, B., additional, Neumann, T., additional, Rauchhaus, M., additional, Angermann, C. E., additional, Katus, H. A., additional, Ertl, G. E., additional, and Störk, S., additional

Published
2011
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40. Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Author

Charron, P., primary, Arad, M., additional, Arbustini, E., additional, Basso, C., additional, Bilinska, Z., additional, Elliott, P., additional, Helio, T., additional, Keren, A., additional, McKenna, W. J., additional, Monserrat, L., additional, Pankuweit, S., additional, Perrot, A., additional, Rapezzi, C., additional, Ristic, A., additional, Seggewiss, H., additional, van Langen, I., additional, and Tavazzi, L., additional

Published
2010
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43. What do tachycardiomyopathy belong to?: reply

Author

Elliott, P., primary, Andersson, B., additional, Arbustini, E., additional, Bilinska, Z., additional, Cecchi, F., additional, Charron, P., additional, Dubourg, O., additional, Kuhl, U., additional, Maisch, B., additional, McKenna, W. J., additional, Monserrat, L., additional, Pankuweit, S., additional, Rapezzi, C., additional, Seferovic, P., additional, Tavazzi, L., additional, and Keren, A., additional

Published
2008
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44. The new European definition of cardiomyopathies: which space for muscle dystrophies?: reply

Author

Elliott, P., primary, Andersson, B., additional, Arbustini, E., additional, Bilinska, Z., additional, Cecchi, F., additional, Charron, P., additional, Dubourg, O., additional, Kuhl, U., additional, Maisch, B., additional, McKenna, W. J., additional, Monserrat, L., additional, Pankuweit, S., additional, Rapezzi, C., additional, Seferovic, P., additional, Tavazzi, L., additional, and Keren, A., additional

Published
2008
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45. Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases

Author

Elliott, P., primary, Andersson, B., additional, Arbustini, E., additional, Bilinska, Z., additional, Cecchi, F., additional, Charron, P., additional, Dubourg, O., additional, Kuhl, U., additional, Maisch, B., additional, McKenna, W. J., additional, Monserrat, L., additional, Pankuweit, S., additional, Rapezzi, C., additional, Seferovic, P., additional, Tavazzi, L., additional, and Keren, A., additional

Published
2007
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47. Suspected inflammatory cardiomyopathy.

Author

Karatolios, K., Maisch, B., and Pankuweit, S.

Abstract

Copyright of Herz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015
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