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236 results on '"Paniccia, Rita"'

1. Patient blood management in cardiac surgery: The “Granducato algorithm”

Author

Bartolozzi, Carlo, Bertini, Pietro, Bianchi, Cecilia, Castellani, Debora, Cariello, Claudia, Del Sarto, Paolo, Marchetti, Luca, Marianello, Daniele, Marusceac, Cornel, Pastorino, Alessandra, Solinas, Marco, Scolletta, Sabino, Simioni, Paolo, Campagnolo, Valter, Celiento, Michele, Fontanari, Paolo, Guadagnucci, Alberto, Guarracino, Fabio, Haxhiademi, Dorela, Paniccia, Rita, Simeone, Felicetta, and Ranucci, Marco

Published
2019
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11. Residual platelet reactivity to predict long-term clinical outcomes after clopidogrel loading in patients with acute coronary syndromes: comparison of different cutoff values by light transmission aggregometry from the responsiveness to clopidogrel and stent thrombosis 2-acute coronary syndrome (RECLOSE 2-ACS) study

Author

Valenti, Renato, Marcucci, Rossella, Capodanno, Davide, De Luca, Giuseppe, Migliorini, Angela, Gori, Anna Maria, Parodi, Guido, Giusti, Betti, Carrabba, Nazario, Paniccia, Rita, Cantini, Giulia, Marrani, Marco, Gensini, Gian Franco, Abbate, Rosanna, and Antoniucci, David

Published
2015
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23. Platelet Reactivity in Hepatitis C Virus–Infected Patients on Dual Antiplatelet Therapy for Acute Coronary Syndrome

Author

Scudiero, Fernando, primary, Valenti, Renato, additional, Marcucci, Rossella, additional, Sanna, Giuseppe D., additional, Gori, Anna Maria, additional, Migliorini, Angela, additional, Vitale, Raffaele, additional, Giusti, Betti, additional, De Vito, Elena, additional, Corda, Giulia, additional, Paniccia, Rita, additional, Zirolia, Davide, additional, Canonico, Mario E., additional, and Parodi, Guido, additional

Published
2020
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26. Increased renal formation of thromboxane A2 and prostaglandin F2-alpha in heart failure

Author

Castellani, Sergio, Paladini, Barbara, Paniccia, Rita, Di Serio, Claudia, Vallotti, Barbara, Ungar, Andrea, Fumagalli, Stefano, Cantini, Claudia, Poggesi, Loredana, and Neri Serneri, Gian Gastone

Subjects
Heart failure -- Physiological aspects, Thromboxane synthetase -- Measurement, Synthetic prostaglandins F -- Measurement, Kidney function tests -- Analysis, Health
Published
1997

27. Patient blood management in cardiac surgery: The “Granducato algorithm”

Author

Scolletta, Sabino, primary, Simioni, Paolo, additional, Campagnolo, Valter, additional, Celiento, Michele, additional, Fontanari, Paolo, additional, Guadagnucci, Alberto, additional, Guarracino, Fabio, additional, Haxhiademi, Dorela, additional, Paniccia, Rita, additional, Simeone, Felicetta, additional, Ranucci, Marco, additional, Bartolozzi, Carlo, additional, Bertini, Pietro, additional, Bianchi, Cecilia, additional, Castellani, Debora, additional, Cariello, Claudia, additional, Del Sarto, Paolo, additional, Marchetti, Luca, additional, Marianello, Daniele, additional, Marusceac, Cornel, additional, Pastorino, Alessandra, additional, and Solinas, Marco, additional

Published
2019
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30. Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes

Author

Prisco, Domenico, Filippini, Monica, Francalanci, Isa, Paniccia, Rita, Gensini, Gian Franco, Abbate, Rosanna, and Neri Serneri, Gian Gastone

Subjects
Omega-3 fatty acids -- Physiological aspects, Phospholipids -- Health aspects, Blood plasma -- Health aspects, Erythrocytes -- Health aspects, Food/cooking/nutrition, Health
Abstract

To characterize the time course of plasma and red blood cell (RBC) changes after n-3 polyunsaturated fatty acid (PUFA) supplementation, 20 healthy male volunteers were randomly assigned to receive either four 1-g capsules of n-3 PUFA ethyl esters or four 1-g capsules of olive oil (as placebo) for a period of 4 mo, followed by a 3-mo washout period. Fatty acids of plasma and RBC phospholipid fractions were analyzed at 0, 2, and 4 mo of treatment and at 1, 2, and 3 mo of washout. During n-3 PUFA supplementation, accumulations of eicosapentaenoic (EPA), docosapentaenoic (DPA), and docosahexaenoic (DHA) acids were marked after 2 mo with differences among different fractions of plasma and RBCs in further accumulation up to 4 mo. During the first and second months of the washout, slight differences were observed in changes of various fatty acids among different phospholipid fractions, but after 3 mo of washout, only minor alterations were still detectable with respect to pretreatment values. These data confirm the complex relations among different fatty acid pools after n-3 PUFA supplementation. Am J Clin Nutr 1996;63:925-32.

Published
1996

31. Point-of-Care Testing of Hemostasis in Cardiac Surgery

Author

Paniccia Rita and Prisco Domenico

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract An excessive perioperative blood loss, that requires transfusion of blood products, sometimes occurs in patients undergoing cardiopulmonary bypass for cardiac surgery. Blood loss and transfusion requirements in these patients may be reduced with a better control of heparin treatment and its reversal. Blood component administration in patients with excessive post-cardiopulmonary bypass bleeding has been empiric for a long time due to turnaround times of laboratory coagulation tests. Devices are now available for rapid, point-of-care assessment of hemostasis alterations to allow an appropriate, targeted therapy. In particular, a quick evaluation of platelet and coagulation defects with new point-of-care devices can optimize the administration of pharmacological and transfusion-based therapy in patients with excessive bleeding after cardiopulmonary bypass.

Published
2003
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34. Platelet function tests: a comparative review

Author

Paniccia, Rita, Priora,Raffaella, Alessandrello Liotta,Agatina, and Abbate,Rosanna

Subjects
Vascular Health and Risk Management
Abstract

Rita Paniccia,1,2 Raffaella Priora,1,2 Agatina Alessandrello Liotta,2 Rosanna Abbate1,2 1Department of Experimental and Clinical Medicine, Thrombosis Center, University of Florence, Florence, Italy; 2Department of Heart and Vessels, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy Abstract: In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet defects promote bleeding, whereas the high residual reactivity of platelets in patients on antiplatelet therapies moves forward thromboembolic complications. The biochemical mechanisms of the different phases of platelet activation – adhesion, shape change, release reaction, and aggregation – have been well delineated, whereas their complete translation into laboratory assays has not been so fulfilled. Laboratory tests of platelet function, such as bleeding time, light transmission platelet aggregation, lumiaggregometry, impedance aggregometry on whole blood, and platelet activation investigated by flow cytometry, are traditionally utilized for diagnosing hemostatic disorders and managing patients with platelet and hemostatic defects, but their use is still limited to specialized laboratories. To date, a point-of-care testing (POCT) dedicated to platelet function, using pertinent devices much simpler to use, has now become available (ie, PFA-100, VerifyNow System, Multiplate Electrode Aggregometry [MEA]). POCT includes new methodologies which may be used in critical clinical settings and also in general laboratories because they are rapid and easy to use, employing whole blood without the necessity of sample processing. Actually, these different platelet methodologies for the evaluation of inherited and acquired bleeding disorders and/or for monitoring antiplatelet therapies are spreading and the study of platelet function is strengthening. In this review, well-tried and innovative platelet function tests and their methodological features and clinical applications are considered. Keywords: platelets, method, point-of-care testing, laboratory assessment, bleeding, thrombosis

Published
2015

35. Early sequence of cardiac adaptations and growth factor formation in pressure- and volume-overload hypertrophy

Author

MODESTI, PIETRO AMEDEO, VANNI, SIMONE, BERTOLOZZI, IACOPO, CECIONI, ILARIA, POLIDORI, GIANLUCA, PANICCIA, RITA, BANDINELLI, BRUNELLA, PERNA, AVIO, LIGUORI, PIERO, BODDI, MARIA, GALANTI, GIORGIO, and SERNERI, GIAN GASTONE NERI

Subjects
Endothelin -- Research, Angiotensin -- Research, Insulin-like growth factor 1 -- Research, Heart -- Contraction, Swine -- Research, Biological sciences
Abstract

Early sequence of cardiac adaptations and growth factor formation in pressure- and volume-overload hypertrophy. Am J Physiol Heart Circ Physiol 279: H976-H985, 2000.--To investigate the time sequence of cardiac growth factor formation, echocardiographic and hemodynamic measurements were performed at scheduled times, and mRNAs for angiotensinogen, prepro-endothelin-1 (ppET-1), and insulin-like growth factor I (IGF-I) were quantified with RT-PCR and localized with in situ hybridization in pigs (fluothane anesthesia) by use of pressure or volume overload (aortic banding and aorta-cava fistula, respectively). Relative peptide formation was also measured by radioimmunoassay. In pressure overload, angiotensinogen and ppET-1 mRNA overexpression on myocytes (13 times vs. sham at 3 h and 112 times at 6 h, respectively) was followed by recovery (12 h) of initially decreased (0.5-6 h) myocardial contractility. In volume overload, contractility was not decreased, the angiotensinogen gene was slightly upregulated at 6 h (6.7 times), and ppET-1 was not overexpressed. IGF-I mRNA was overexpressed on myocytes (at 24 h) in both volume and pressure overload (14 times and 37 times, respectively). In the latter setting, a second ppET-1 overexpression was detectable on myocytes at 7 days. In conclusion, acute cardiac adaptation responses involve different growth factor activation over time in pressure versus volume overload; growth factors initially support myocardial contractility and thereafter induce myocardial hypertrophy. endothelin-1; angiotensinogen; insulin-like growth factor I; myocardial contractility; acute overloading; swine

Published
2000

36. Platelet function tests: a comparative review

Author

Paniccia,Rita, Priora,Raffaella, Alessandrello Liotta,Agatina, Abbate,Rosanna, Paniccia,Rita, Priora,Raffaella, Alessandrello Liotta,Agatina, and Abbate,Rosanna

Abstract

Rita Paniccia,1,2 Raffaella Priora,1,2 Agatina Alessandrello Liotta,2 Rosanna Abbate1,2 1Department of Experimental and Clinical Medicine, Thrombosis Center, University of Florence, Florence, Italy; 2Department of Heart and Vessels, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy Abstract: In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet defects promote bleeding, whereas the high residual reactivity of platelets in patients on antiplatelet therapies moves forward thromboembolic complications. The biochemical mechanisms of the different phases of platelet activation – adhesion, shape change, release reaction, and aggregation – have been well delineated, whereas their complete translation into laboratory assays has not been so fulfilled. Laboratory tests of platelet function, such as bleeding time, light transmission platelet aggregation, lumiaggregometry, impedance aggregometry on whole blood, and platelet activation investigated by flow cytometry, are traditionally utilized for diagnosing hemostatic disorders and managing patients with platelet and hemostatic defects, but their use is still limited to specialized laboratories. To date, a point-of-care testing (POCT) dedicated to platelet function, using pertinent devices much simpler to use, has now become available (ie, PFA-100, VerifyNow System, Multiplate Electrode Aggregometry [MEA]). POCT includes new methodologies which may be used in critical clinical settings and also in general laboratories because they are rapid and easy to use, employing whole blood without the necessity of sample processing. Actually, these different platelet methodologies for the evaluation of inherited and acquired bleeding disorders and/or for monitoring antiplatelet therapies are spreading and the study of platelet function is strengthening. In this review, well-tri

Published
2015

40. Residual platelet reactivity to predict long-term clinical outcomes after clopidogrel loading in patients with acute coronary syndromes: comparison of different cutoff values by light transmission aggregometry from the responsiveness to clopidogrel and stent thrombosis 2-acute coronary syndrome (RECLOSE 2-ACS) study

Author

Valenti, Renato, primary, Marcucci, Rossella, additional, Capodanno, Davide, additional, De Luca, Giuseppe, additional, Migliorini, Angela, additional, Gori, Anna Maria, additional, Parodi, Guido, additional, Giusti, Betti, additional, Carrabba, Nazario, additional, Paniccia, Rita, additional, Cantini, Giulia, additional, Marrani, Marco, additional, Gensini, Gian Franco, additional, Abbate, Rosanna, additional, and Antoniucci, David, additional

Published
2014
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42. Point-of-Care Testing of Hemostasis in Cardiac Surgery

Author

Prisco, Domenico and Paniccia, Rita

Subjects
lcsh:RC633-647.5, Review, lcsh:Diseases of the blood and blood-forming organs
Abstract

An excessive perioperative blood loss, that requires transfusion of blood products, sometimes occurs in patients undergoing cardiopulmonary bypass for cardiac surgery. Blood loss and transfusion requirements in these patients may be reduced with a better control of heparin treatment and its reversal. Blood component administration in patients with excessive post-cardiopulmonary bypass bleeding has been empiric for a long time due to turnaround times of laboratory coagulation tests. Devices are now available for rapid, point-of-care assessment of hemostasis alterations to allow an appropriate, targeted therapy. In particular, a quick evaluation of platelet and coagulation defects with new point-of-care devices can optimize the administration of pharmacological and transfusion-based therapy in patients with excessive bleeding after cardiopulmonary bypass.

Published
2003

44. Increased renal formation of thromboxane A 2 and prostaglandin F 2α in heart failure

Author

Castellani, Sergio, Paladini, B., Paniccia, Rita, Di Serio, Claudia, Vallotti, B., Ungar, A., Fumagalli, Stefano, Cantini, C., Poggesi, Loredana, and Neri Serneri, Gian Gastone

Subjects
cardiovascular system, KIDNEY, HUMANS, NORADRENALINE, PROSTACYCLIN, ACTIVATION, EXPRESSION, ENDOTHELIN, RECEPTOR, lipids (amino acids, peptides, and proteins), circulatory and respiratory physiology
Published
1997

45. TCT-442 The Impact of High Residual Platelet Reactivity After Clopidogrel Loading on Cardiac Mortality in Patients Treated by Percutaneous Coronary Intervention for Chronic Total Occlusion

Author

Valenti, Renato, primary, Marcucci, Rossella, additional, Migliorini, Angela, additional, Gori, Anna Maria, additional, Carrabba, Nazario, additional, Giusti, Betti, additional, Cerisano, Giampaolo, additional, Parodi, Guido, additional, Paniccia, Rita, additional, Abbate, Rosanna, additional, and Antoniucci, David, additional

Published
2012
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46. TCT-726 Residual Platelet Reactivity Threshold After Clopidogrel Loading Dose to Predict Long-term Clinical Outcome in Patients with Acute Coronary Syndrome: Insights from the RECLOSE2-ACS Study

Author

Valenti, Renato, primary, Marcucci, Rossella, additional, Migliorini, Angela, additional, Gori, Anna Maria, additional, Parodi, Guido, additional, Giusti, Betti, additional, carrabba, nazario, additional, Paniccia, Rita, additional, Abbate, Rosanna, additional, and Antoniucci, David, additional

Published
2012
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47. Perioperative assessment of platelet function by Thromboelastograph® Platelet Mapping™ in cardiovascular patients undergoing non-cardiac surgery

Author

Cattano, Davide, primary, Altamirano, Alfonso V., additional, Kaynak, Husnu E., additional, Seitan, Carmen, additional, Paniccia, Rita, additional, Chen, Zhongxue, additional, Huang, Hanwen, additional, Prisco, Domenico, additional, Hagberg, Carin A., additional, and Pivalizza, Evan G., additional

Published
2012
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