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1. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Ducroux, Célina, primary, Derex, Laurent, additional, Nourredine, Mikaïl, additional, Haesebaert, Julie, additional, Buisson, Marielle, additional, Alesefir, Walid, additional, Boisseau, William, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Diestro, Jose Danilo B., additional, Eker, Omer, additional, Eneling, Johanna, additional, Gioia, Laura C., additional, Iancu, Daniella, additional, Jacquin, Grégory, additional, Odier, Céline, additional, Stapf, Christian, additional, Raymond, Jean, additional, Roy, Daniel, additional, Weill, Alain, additional, Lapergue, Bertrand, additional, Poppe, Alexandre Y., additional, Piotin, Michel, additional, Blanc, Raphael, additional, Escalard, Hocine Redjem Simon, additional, Desilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Hebert, Solène, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Seners, Pierre, additional, Raynouard, Igor, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Savatovsky, Julien, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, Weisenburger-Lile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Consoli, Arturo, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Nighoghossian, Norbert, additional, Riva, Roberto, additional, Turjman, Francis, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Lukaszewicz, Anne Claire, additional, Philippeau, Frédéric, additional, Cakmak, Serkan, additional, Blanc-Lasserre, Karine, additional, Vallet, Anne-Evelyne, additional, Marnat, Gaultier, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Sibon, Igor, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Bourcier, Romain, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Gory, Benjamin, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Richard, Sébastien, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Riou-Comte, Nolwenn, additional, Audibert, Gérard, additional, Voicu, Marcela, additional, Alb, Ionel, additional, Reitter, Marie, additional, Brezeanu, Madalina, additional, Masson, Agnès, additional, Tabarna, Adriana, additional, Podar, Iona, additional, Macian-montoro, Francisco, additional, Saleme, Suzanna, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Dargazanli, Cyril, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, ter Schiphorst, Adrien, additional, Francois, Eugene, additional, Vannier, Stéphane, additional, Ferre, Jean-christophe, additional, Raoult, Helene, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Langnier-Lemercier, Sophie, additional, Samson, Yves, additional, Rosso, Charlotte, additional, Leger, Anne, additional, Deltour, Sandrine, additional, Clarencon, Frederic, additional, Shotar, Eimad, additional, Spelle, Laurent, additional, Denier, Christian, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Naggara, Olivier, additional, Hassen, Wagih Ben, additional, Boulouis, Grégoire, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Kerleroux, Basile, additional, Turc, Guillaume, additional, Domigo, Valérie, additional, Lamy, Catherine, additional, Birchenall, Julia, additional, Isabel, Clothilde, additional, Lun, François, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Januel, Anne Christine, additional, Olivot, Jean-Marc, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Albucher, Jean François, additional, Calviere, Lionel, additional, Darcourt, Jean, additional, Tall, Philippe, additional, Bellanger, Guillaume, additional, Fontaine, Louis, additional, Touze, Emmanuel, additional, Barbier, Charlotte, additional, Schneckenburger, Romain, additional, Boulanger, Marion, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Timsit, Serge, additional, Gentric, Jean-christophe, additional, Ognard, Julien, additional, Merrien, Francois Mathias, additional, Wermester, Ozlem Ozkul, additional, Massardier, Evelyne, additional, Papagiannaki, Chrysanthi, additional, Bourdain, Frédéric, additional, Bernady, Patricia, additional, Lagoarde-Segot, Laurent, additional, Cailliez, Hélène, additional, Veunac, Louis, additional, Higue, David, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Beaujeux, Rémi, additional, Dan-Sorin, Mihoc, additional, Manisor, Monica, additional, Le Bras, Anthony, additional, Evain, Sarah, additional, Le Guen, Arnaud, additional, Richter, Sebastian, additional, Hubrecht, Regis, additional, Demasles, Stéphanie, additional, Barroso, Bruno, additional, Sablot, Denis, additional, Farouil, Geoffroy, additional, Tardieu, Maxime, additional, Smadja, Philippe, additional, Aptel, Sabine, additional, and Seiler, Ian, additional

Published
2023
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2. 24-Hour Carotid Stent Patency and Outcomes After Endovascular Therapy: A Multicenter Study

Author

Allard, Julien, primary, Delvoye, François, additional, Pop, Raoul, additional, Labreuche, Julien, additional, Maier, Benjamin, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Zhu, François, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Spelle, Laurent, additional, Denier, Christian, additional, Richard, Sébastien, additional, Piotin, Michel, additional, Gory, Benjamin, additional, Mazighi, Mikael, additional, Blanc, Raphael, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Dessilles, Jean-Philippe, additional, Smajda, Stanislas, additional, Solène, Hebert, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Pierre, Seners, additional, Igor, Raynouard, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Maacha, Malek Ben, additional, Thion, Laurie-Anne, additional, Augustin, Lecler, additional, Julien, Savatovsjy, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, WeisenburgerLile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Coussy, Alexis, additional, Papillon, Lisa, additional, Papaxanthos, Jean, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Lacour, Jean-Christophe, additional, Riou-Comte, Nolwenn, additional, Voicu, Marcela, additional, Alb, Lionel, additional, Reitter, Marie, additional, Brezeanu, Madalina, additional, Masson, Agnès, additional, Tabarna, Adriana, additional, Podar, Iona, additional, Macian-Montoro, Francisco, additional, Saleme, Suzanna, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Dargazanli, Cyril, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, Ter Schiphorst, Adrien, additional, Ferre, Jean-Christophe, additional, Raoult, Hélène, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, and Langnier-Lemercier, Sophie, additional

Published
2023
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4. Determination of Interactive States of Immune Checkpoint Regulators in Lung Metastases after Radiofrequency Ablation

Author

Institut Bergonié, Groupement Interrégional de Recherche Clinique et d’Innovation (France), Boston Scientific Corporation, Eusko Jaurlaritza, Ministerio de Economía y Competitividad (España), Bellera, Carine [0000-0001-7926-4671], Miles, James, Soubeyran, Isabelle, Marliot, Florence, Pangon, Nicolas, Italiano, Antoine, Bellera, Carine, Ward, Stephen G., Pagès, Franck, Palussière, Jean, Larijani, Banafshé, Institut Bergonié, Groupement Interrégional de Recherche Clinique et d’Innovation (France), Boston Scientific Corporation, Eusko Jaurlaritza, Ministerio de Economía y Competitividad (España), Bellera, Carine [0000-0001-7926-4671], Miles, James, Soubeyran, Isabelle, Marliot, Florence, Pangon, Nicolas, Italiano, Antoine, Bellera, Carine, Ward, Stephen G., Pagès, Franck, Palussière, Jean, and Larijani, Banafshé

Abstract

[Background] Cases of the spontaneous regression of multiple pulmonary metastases, after radiofrequency ablation (RFA), of a single lung metastasis, have been documented to be mediated by the immune system. The interaction of immune checkpoints, e.g., PD-1/PD-L1 and CTLA-4/CD80, may explain this phenomenon. The purpose of this study is to identify and quantify immune mechanisms triggered by RFA of pulmonary metastases originating from colorectal cancer., [Methods] We used two-site time-resolved Förster resonance energy transfer as determined by frequency-domain FLIM (iFRET) for the quantification of receptor–ligand interactions. iFRET provides a method by which immune checkpoint interaction states can be quantified in a spatiotemporal manner. The same patient sections were used for assessment of ligand–receptor interaction and intratumoral T-cell labeling., [Conclusion] The checkpoint interaction states quantified by iFRET did not correlate with ligand expression. We show that immune checkpoint ligand expression as a predictive biomarker may be unsuitable as it does not confirm checkpoint interactions. In pre-RFA-treated metastases, there was a significant and negative correlation between PD-1/PD-L1 interaction state and intratumoral CD3+ and CD8+ density. The negative correlation of CD8+ and interactive states of PD-1/PD-L1 can be used to assess the state of immune suppression in RFA-treated patients.

Published
2022

5. Impact of Strategy on Clinical Outcome in Large Vessel Occlusion Stroke Successfully Reperfused: ETIS Registry Results

Author

Douarinou, Marian, primary, Gory, Benjamin, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Kyheng, Maeva, additional, Labreuche, Julien, additional, Anadani, Mohammad, additional, Blanc, Raphael, additional, Marnat, Gaultier, additional, Bourcier, Romain, additional, Sibon, Igor, additional, Eugène, François, additional, Vannier, Stéphane, additional, Audibert, Gérard, additional, Mione, Gioia, additional, Richard, Sébastien, additional, Piotin, Michel, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Dessilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Solène, Hebert, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Pierre, Seners, additional, Igor, Raynouard, additional, Corabianu, Ovide, additional, Broucker, Thomas de, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Maacha, Malek Ben, additional, Thion, Laurie-Anne, additional, Augustin, Lecler, additional, Julien, Savatovsjy, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, WeisenburgerLile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Gaalon, Solène de, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Lacour, Jean-Christophe, additional, Riou- Comte, Nolwenn, additional, Voicu, Marcela, additional, Alb, Lionel, additional, Reitter, Marie, additional, Brezeanu, Madalina, additional, Masson, Agnès, additional, Tabarna, Adriana, additional, Podar, Iona, additional, Macian-Montoro, Francisco, additional, Saleme, Suzanna, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Dargazanli, Cyril, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, Schiphorst, Adrien ter, additional, Ferre, Jean-Christophe, additional, Raoult, Hélène, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, and Langnier-Lemercier, Sophie, additional

Published
2022
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6. Impact of Prior Antiplatelet Therapy on Outcomes After Endovascular Therapy for Acute Stroke: Endovascular Treatment in Ischemic Stroke Registry Results

Author

Couture, Marie, primary, Finitsis, Stephanos, additional, Marnat, Gaultier, additional, Richard, Sébastien, additional, Bourcier, Romain, additional, Constant-dits-Beaufils, Pacôme, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Mazighi, Mikaël, additional, Blanc, Raphaël, additional, Eugène, François, additional, Vannier, Stéphane, additional, Spelle, Laurent, additional, Denier, Christian, additional, Touzé, Emmanuel, additional, Barbier, Charlotte, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Rosso, Charlotte, additional, Clarençon, Frédéric, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrysanthi, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Lebras, Anthony, additional, Evain, Sarah, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Timsit, Serge, additional, Gentric, Jean-Christophe, additional, Bourdain, Frédéric, additional, Veunac, Louis, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Gory, Benjamin, additional, Sibon, Igor, additional, Piotin, Michel, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Dessilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Solène, Hebert, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Seners, Pierre, additional, Raynouard, Igor, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Savatovsjy, Julien, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, WeisenburgerLile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Liao, Liang, additional, Tonnelet, Romain, additional, Liao, François, additional, Zhu, Emmanuelle, additional, Schmitt, Sophie, additional, Planel, Sébastien, additional, Richard, Lisa, additional, Humbertjean, Gioia, additional, Mione, Jean-Christophe, additional, Lacour, Nolwenn, additional, Riou-Comte, Gérard, additional, Audibert, Marcela, additional, Voicu, Lionel, additional, Alb, Marie, additional, Reitter, Madalina, additional, Brezeanu, Agnès, additional, Masson, Adriana, additional, Tabarna, Iona, additional, Podar, Sarah, additional, Guy, Fatiha, additional, Bechiri, Fatiha, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Gimenez, Laetitia, additional, Cosnard, Alexandre, additional, Costalat, Vincent, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, ter Schiphorst, Adrien, additional, Ferre, Jean-Christophe, additional, Raoult, Hélène, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Maurice, Sophie Langnier-Lemercier, Axelle, additional, Cochennec, Sabrina, additional, Pinault, Mélanie, additional, Shotar, Eimad, additional, Sourour, Nader, additional, Lenck, Stéphanie, additional, Premat, Kévin, additional, Anne Léger, Yves Samson, additional, Crozier, Sophie, additional, Baronnet, Flore, additional, Alamowitch, Sonia, additional, Bottin, Laure, additional, Yger, Mathon, additional, Degos, Vincent, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Sarov, Mariana, additional, Legris, Nicolas, additional, Hassen, Wagih Ben, additional, Boulouis, Grégoire, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Kerleroux, Basile, additional, Domigo, Valérie, additional, Lamy, Catherine, additional, Birchenall, Julia, additional, Isabel, Clothilde, additional, Lun, François, additional, Januel, Anne Christine, additional, Olivot, Jean-Marc, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Albucher, Jean François, additional, Calviere, Lionel, additional, Darcourt, Jean, additional, Bellanger, Guillaume, additional, Tall, Philippe, additional, Schneckenburger, Romain, additional, Boulanger, Marion, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Gauberti, Maxime, additional, Ognard, Julien, additional, Mathias Merrien., Francois, additional, Wermester, Ozlem Ozku, additional, Massardier, Evelyne, additional, Triquenot, Aude, additional, Lefebvre, Margeaux, additional, Bernady, Patricia, additional, Lagoarde-Segot, Laurent, additional, Cailliez, Hélène, additional, Higue, David, additional, Quenardelle, Veronique, additional, Lauer, Valerie, additional, Gheoca, Roxana, additional, Pierre-Paul, Irene, additional, Beaujeux, Remy, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Pottecher, Julien, additional, Meyer, Alain, additional, Chamaraux-Tran, Thiên-Nga, additional, Le Bras, Anthony, additional, Le Guen, Arnaud, additional, Nighoghossian, Norbert, additional, Riva, Roberto, additional, Eker, Omer, additional, turjman, Francis, additional, Derex, Laurent, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Claire Lukaszewicz, Anne, additional, Philippeau, Frédéric, additional, Cakmak, Serkan, additional, Blanc-Lasserre, Karine, additional, and Vallet, Anne-Evelyne, additional

Published
2021
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7. Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry

Author

Happi Ngankou, Emmanuel, primary, Gory, Benjamin, additional, Marnat, Gaultier, additional, Richard, Sébastien, additional, Bourcier, Romain, additional, Sibon, Igor, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Maïer, Benjamin, additional, Blanc, Raphaël, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Vannier, Stéphane, additional, Spelle, Laurent, additional, Denier, Christian, additional, Boulanger, Marion, additional, Gauberti, Maxime, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Clarençon, Frédéric, additional, Rosso, Charlotte, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrysanthi, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Lebras, Anthony, additional, Evain, Sarah, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Timsit, Serge, additional, Gentric, Jean-Christophe, additional, Bourdain, Frédéric, additional, Veunac, Louis, additional, Eugène, François, additional, Finitsis, Stephanos, additional, Piotin, Michel, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Dessilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Solène, Hebert, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Seners, Pierre, additional, Raynouard, Igor, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Maacha, Malek Ben, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Savatovsjy, Julien, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, WeisenburgerLile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Riou-Comte, Nolwenn, additional, Audibert, Gérard, additional, Voicu, Marcela, additional, Alb, Lionel, additional, Reitter, Marie, additional, Brezeanu, Madalina, additional, Masson, Agnès, additional, Tabarna, Adriana, additional, Podar, Iona, additional, Guy, Sarah, additional, Bechiri, Fatiha, additional, Bourst, Pauline, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Gimenez, Laetitia, additional, Cosnard, Alexandre, additional, Costalat, Vincent, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, ter Schiphorst, Adrien, additional, Ferre, Jean-Christophe, additional, Raoult, Hélène, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Langnier-Lemercier, Sophie, additional, Maurice, Axelle, additional, Cochennec, Sabrina, additional, Pinault, Mélanie, additional, Shotar, Eimad, additional, Sourour, Nader, additional, Lenck, Stéphanie, additional, Premat, Kévin, additional, Léger, Yves Samson Anne, additional, Crozier, Sophie, additional, Baronnet, Flore, additional, Alamowitch, Sonia, additional, Bottin, Laure, additional, Yger, Mathon, additional, Degos, Vincent, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Sarov, Mariana, additional, Legris, Nicolas, additional, Hassen, Wagih Ben, additional, Boulouis, Grégoire, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Kerleroux, Basile, additional, Domigo, Valérie, additional, Lamy, Catherine, additional, Birchenall, Julia, additional, Isabel, Clothilde, additional, Lun, François, additional, Januel, Anne Christine, additional, Olivot, Jean-Marc, additional, Fontaine, Louis, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Albucher, Jean François, additional, Calviere, Lionel, additional, Darcourt, Jean, additional, Bellanger, Guillaume, additional, Tall, Philippe, additional, Touze, Emmanuel, additional, Barbier, Charlotte, additional, Schneckenburger, Romain, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Ognard, Julien, additional, Merrien, Francois Mathias, additional, Wermester, Ozlem Ozku, additional, Massardier, Evelyne, additional, Triquenot, Aude, additional, Lefebvre, Margeaux, additional, Bernady, Patricia, additional, Lagoarde-Segot, Laurent, additional, Cailliez, Hélène, additional, Higue, David, additional, Quenardelle, Veronique, additional, Lauer, Valerie, additional, Gheoca, Roxana, additional, Pierre-Paul, Irene, additional, Beaujeux, Remy, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Pottecher, Julien, additional, Meyer, Alain, additional, Chamaraux-Tran, Thiên-Nga, additional, Le Bras, Anthony, additional, and Le Guen, Arnaud, additional

Published
2021
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8. Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry

Author

Ngankou, Emmanuel Happi, Gory, Benjamin, Marnat, Gaultier, Richard, Sébastien, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Maïer, Benjamin, Blanc, Raphaël, Lapergue, Bertrand, Consoli, Arturo, Vannier, Stéphane, Spelle, Laurent, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Saleme, Suzana, Macian, Francisco, Clarençon, Frédéric, Rosso, Charlotte, Naggara, Olivier, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Viguier, Alain, Cognard, Christophe, Lebras, Anthony, Evain, Sarah, Wolff, Valérie, Pop, Raoul, Timsit, Serge, Gentric, Jean Christophe, Bourdain, Frédéric, Veunac, Louis, Eugène, François, Finitsis, Stephanos Nikolaos, Piotin, Michel, Redjem, Hocine, Escalard, Simon, Dessilles, Jean Philippe, Delvoye, François, Smajda, Stanislas, Solène, Hebert, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Seners, Pierre, Raynouard, Igor, Corabianu, Ovide, de Broucker, Thomas, Manchon, Eric, Taylor, Guillaume, Maacha, Malek Ben, Thion, Laurie Anne, Lecler, Augustin, Savatovsjy, Julien, Hospital, Foch, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Weisenburgerlile, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Gariel, Florent, Barreau, Xavier, Berge, Jerome, Menegon, Patrice, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean Sebastien, Briau, Pierre, Pangon, Nicolas, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre Louis, Roy, Monica, Lenoble, Cédric, Desal, Hubert Armand, Guillon, Benoît, de Gaalon, Solène, Preterre, Cécile, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne Laure, Romain, Tonnelet, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean Christophe, Riou-Comte, Nolwenn, Audibert, Gérard, Voicu, Marcela, Alb, Lionel, Reitter, Marie, Brezeanu, Madalina, Masson, Agnès, Tabarna, Adriana, Podar, Iona, Guy, Sarah, Bechiri, Fatiha, Bourst, Pauline, Macian-Montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Gimenez, Laetitia, Cosnard, Alexandre, Costalat, Vincent, Gascou, Grégory, Lefèvre, Pierre Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, ter Schiphorst, Adrien, Ferré, Jean-Christophe, Raoult, Hélène, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Maurice, Axelle, Cochennec, Sabrina, Pinault, Mélanie, Shotar, Eimad, Sourour, Nader Antoine, Lenck, Stéphanie, Premat, Kévin, Anne Léger, Yves Samson, Crozier, Sophie, Baronnet, Flore, Alamowitch, Sonia, Bottin, Laure, Yger, Marion, Degos, Vincent, Chassin, Olivier, Chalumeau, Vanessa, Caroff, Jildaz, Venditti, Laura, Sarov, Mariana, Legris, Nicolas, Hassen, Wagih Ben, Boulouis, Grégoire, Rodriguez-Régent, Christine, Trystram, Denis, Kerleroux, Basile, Domigo, Valérie, Lamy, Catherine, Birchenall, Julia, Isabel, Clothilde, Lun, François, Januel, Anne Christine, Olivot, Jean Marc, Fontaine, Louis, Raposo, Nicolas, Bonneville, Fabrice, Albucher, Jean François, Calviere, Lionel, Darcourt, Jean, Bellanger, Guillaume, Tall, Philippe, Touzé, Emmanuel, Barbier, Charlotte, Schneckenburger, Romain, Cogez, Julien, Guettier, Sophie, Ognard, Julien, Merrien, François Mathias, Wermester, Ozlem Ozku, Massardier, Evelyne Guégan, Triquenot, Aude Bagan, Lefebvre, Margeaux, Bernady, Patricia, Lagoarde-Segot, Laurent, Cailliez, Hélène, Higue, David, Quenardelle, Véronique, Lauer, Valérie, Gheoca, Roxana, Pierre-Paul, Irène Nora, Beaujeux, Remy, Mihoc, Dan, Manisor, Monica, Pottecher, Julien, Meyer, Alain, Chamaraux-Tran, Thiên Nga, Le Bras, Anthony, Le Guen, Arnaud, Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), CHU Bordeaux [Bordeaux], Service de neurologie [CHRU Nancy], Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre hospitalier universitaire de Nantes (CHU Nantes), Neuroradiologie [Hôpital Gui de Chauliac], Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch], Hôpital Foch [Suresnes], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de Neurologie [CHU Rennes], CHU Pontchaillou [Rennes], Service de Neuroradiologie [CHU de Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de neurologie [Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Départment de Neuroradiologie [CHU Caen], Service de Neuroradiologie interventionnelle [CHU Limoges], CHU Limoges, Service de Neurologie [CHU Limoges], CHU Pitié-Salpêtrière [AP-HP], Service de Neurologie [CH Saint-Anne], Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Département de Neuroradiologie [CHU Rouen], Normandie Université (NU)-Normandie Université (NU), Neurologie Vasculaire [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse], Pôle imagerie médicale [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de radiologie [Vannes], Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Département de Neuroradiologie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Service de Neurologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de Neuroradiologie [Brest], Neurologie - Côte Basque, Centre Hospitalier de la Côte Basque (CHCB), Aristotle University of Thessaloniki, Neuroimagerie: méthodes et applications (Empenn), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Embolism, Large vessel, Dissection (medical), Brain ischemia, Postoperative Complications, Risk Factors, Thromboembolism, medicine, Humans, Registries, Aged, Ischemic Stroke, Thrombectomy, Advanced and Specialized Nursing, business.industry, Incidence (epidemiology), Dissection, Incidence, Endovascular Procedures, Middle Aged, medicine.disease, Surgery, Cerebrovascular Disorders, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background and Purpose: Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated the incidence, risk factors, and clinical implications of thrombectomy complications in daily clinical practice. Methods: We used data from the ongoing prospective multicenter observational Endovascular Treatment in Ischemic Stroke Registry in France. The present study is a retrospective analysis of 4029 stroke patients with anterior large vessel occlusions treated with thrombectomy between January 2015 and May 2020 in 18 centers. We systematically collected procedural data, incidence of embolic complications, perforations and dissections, clinical outcome at 90 days, and hemorrhagic complications. Results: Procedural complications occurred in 7.99% (95% CI, 7.17%–8.87%), and embolus to a new territory (ENT) was the most frequent (5.2%). Predictors of ENTs were terminal carotid/tandem occlusion (odds ratio [OR], 5 [95% CI, 2.03–12.31]; P P =0.006). ENTs were associated to worse clinical outcomes (90-day modified Rankin Scale score, 0–2; adjusted OR, 0.4 [95% CI, 0.25–0.63]; P P P =0.011). Perforations occurred in 1.69% (95% CI, 1.31%–2.13%). Predictors of perforations were terminal carotid/tandem occlusions (39.7% versus 27.6%; P =0.028). 40.7% of patients died at 90 days, and the overall rate of poor outcome was 74.6% in case of perforation. Dissections occurred in 1.46% (95% CI, 1.11%–1.88%) and were more common in younger patients (median age, 64.2 versus 70.2 years; P =0.002). Dissections did not affect the clinical outcome at 90 days. Besides dissection, complications were independent of the thrombectomy technique. Conclusions: Thrombectomy complication rate is not negligible, and ENTs were the most frequent. ENTs and perforations were associated with disability and mortality, and terminal carotid/tandem occlusions were a risk factor. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03776877.

Published
2021

9. Effect of Operator's Experience on Proficiency in Mechanical Thrombectomy: A Multicenter Study

Author

François Zhu, Wagih Ben Hassen, Nicolas Bricout, Basile Kerleroux, Kevin Janot, Benjamin Gory, René Anxionnat, Sébastien Richard, Adrien Marchal, Raphael Blanc, Michel Piotin, Arturo Consoli, Denis Trystram, Christine Rodriguez Regent, Jean-Philippe Desilles, David Weisenburger-Lile, Simon Escalard, Denis Herbreteau, Heloise Ifergan, Igor Lima Maldonado, Julien Labreuche, Hilde Henon, Olivier Naggara, Bertrand Lapergue, Grégoire Boulouis, Redjem Hocine, Ciccio Gabriele, Smajda Stanislas, Maier Benjamin, Mazighi Mikael, Obadia Mikael, Sabben Candice, Peres Roxanne, Corabianu Ovide, De Broucker Thomas, Smadja Didier, Alamowitch Sonia, Ille Olivier, Manchon Eric, Garcia Pierre-Yves, Taylor Guillaume, Ben Maacha Malek, Wang Adrien, Evrard Serge, Tchikviladze Maya, Ajili Nadia, Gorza Lucas, Buard Géraldine, Coskun Oguzhan, Di Maria Federico, Rodesh Georges, Zimatore Sergio, Leguen Morgan, Gratieux Julie, Pico Fernando, Rakotoharinandrasana Haja, Tassan Philippe, Poll Roxanna, Marinier Sylvie, Nighoghossian Norbert, Riva Roberto, Eker Omer, Turjman Francis, Derex Laurent, Cho Tae-Hee, Mechtouff Laura, Claire Lukaszewicz Anne, Philippeau Frédéric, Cakmak Serkan, Blanc-Lasserre Karine, Vallet Anne-Evelyne, Marnat Gaultier, Gariel Florent, Barreau Xavier, Berge Jérôme, Menegon Patrice, Sibon Igor, Liegey Sebastien, Olindo Stéphane, Renou Pauline, Sagnier Sharmila, Poli Mathilde, Debruxelles Sabrina, Pangon Nicolas, Bourcier Romain, Detraz Lili, Daumas-Duport Benjamin, Alexandre Pierre-Louis, Roy Monica, Lenoble Cédric, L’allinec Vincent, Girot Jean-Baptiste, Desal Hubert, Bracard Serge, Braun Marc, Derelle Anne-Laure, Tonnelet Romain, Liao Liang, Muszynski Patricio, Schmitt Emmanuelle, Planel Sophie, Humbertjean Lisa, Mione Gioia, Lacour Jean-Christophe, Riou-Comte Nolwenn, Audibert Gérard, Voicu Marcela, Alb Ionel, Reitter Marie, Brezeanu Madalina, Masson Agnès, Tabarna Adriana, Podar Ioana, Macian-Montoro Francisco, Saleme Suzanna, Mounayer Charbel, Rouchaud Aymeric, Costalat Vincent, Arquizan Caroline, Dargazanli Cyril, Gascou Grégory, Lefèvre Pierre-Henri, Derraz Imad, Riquelme Carlos, Gaillard Nicolas, Mourand Isabelle, Corti Lucas, Francois Eugene, Vannier Stéphane, Ferre Jean-Christophe, Raoult Helene, Ronziere Thomas, Lassale Maria, Paya Christophe, Gauvrit Jean-Yves, Tracol Clément, Langnier-Lemercier Sophie, Samson Yves, Rosso Charlotte, Leger Anne, Deltour Sandrine, Clarencon Frederic, Shotar Eimad, Spelle Laurent, Denier Christian, Chassin Olivier, Chalumeau Vanessa, Caroff Jildaz, Venditti Laura, Turc Guillaume, Seners Pierre, Domigo Valérie, Lamy Catherine, Birchenall Julia, Isabel Clothilde, Viguier Alain, Cognard Christophe, Christine Januel Anne, Olivot Jean-Marc, Raposo Nicolas, Bonneville Fabrice, François Albucher Jean, Calviere Lionel, Touze Emmanuel, Barbier Charlotte, Schneckenburger Romain, Boulanger Marion, Cogez Julien, Guettier Sophie, Timsit Serge, Gentric Jean-Christophe, Ognard Julien, Mathias Merrien Francois, Ozkul Wermester Ozlem, Massardier Evelyne, Papagiannaki Chrysanthi, Bourdain Frédéric, Patricia Bernady, Lagoarde-Segot Laurent, Cailliez Hélène, Veunac Louis, Higue David, Wolff Valérie, Pop Raoul, Beaujeux Rémi, Mihoc Dan-Sorin, Manisor Monica, Le Bras Anthony, Evain Sarah, Le Guen Arnaud, Richter Sebastian, Hubrecht Regis, Demasles Stéphanie, Barroso Bruno, Zuber Mathieu, Farhat Wassim, Alias Quentin, Lun François, Stenvenoot Delphine, Heinzlef Olivier, Godon Hardy Sylvie, Bohotin Valentin, and Grimaud Jérôme

Subjects
medicine.medical_specialty, Standard of care, Time Factors, Neuroradiologist, 030204 cardiovascular system & hematology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Operator (computer programming), Medicine, Humans, Registries, Thrombectomy, Advanced and Specialized Nursing, Surgeons, business.industry, Cerebral infarction, Endovascular Procedures, Cerebral Infarction, medicine.disease, Mechanical thrombectomy, Stroke, Multicenter study, Ischemic stroke, Reperfusion, Physical therapy, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Background and Purpose: We aimed to evaluate among trained interventional neuroradiologist, whether increasing individual experience was associated with an improvement in mechanical thrombectomy (MT) procedural performance metrics. Methods: Individual MT procedural data from 5 centers of the Endovascular Treatment in Ischemic Stroke registry and 2 additional high-volume stroke centers were pooled. Operator experience was defined for each operator as a continuous variable, cumulating the number of MT procedures performed since January 2015, as MT became standard of care or, if later than this date, since the operator started performing mechanical thrombectomies in autonomy. We tested the associations between operator’s experience and procedural metrics. Results: A total of 4516 procedures were included, performed by 36 operators at 7 distinct centers, with a median of 97.5 endovascular treatment procedures per operator (interquartile range, 57–170.2) over the study period. Higher operator’s experience, analyzed as a continuous variable, was associated with a significantly shorter procedural duration (β estimate, −3.98 [95% CI, −5.1 to −2.8]; P P =0.013). Conclusions: In trained interventional neuroradiologists, increasing experience in MT is associated with significantly shorter procedural duration and better reperfusion rates, with a theoretical ceiling effect observed after around 100 procedures. These results may inform future training and practice guidelines to set minimal experience standards before autonomization, and to set-up operators’ recertification processes tailored to individual case volume and prior experience.

Published
2021

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