1,996 results on '"Panganiban AT"'
Search Results
2. Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures
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Lee, Jiwon, Xue, Xiangning, Au, Emily, McIntyre, William B., Asgariroozbehani, Roshanak, Panganiban, Kristoffer, Tseng, George C., Papoulias, Maria, Smith, Emily, Monteiro, Jonathan, Shah, Divia, Maksyutynska, Kateryna, Cavalier, Samantha, Radoncic, Emril, Prasad, Femin, Agarwal, Sri Mahavir, Mccullumsmith, Robert, Freyberg, Zachary, Logan, Ryan W., and Hahn, Margaret K.
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- 2024
- Full Text
- View/download PDF
3. Suroy-Suroy: An Immersive Virtual Reality Therapy Game for Persons Living with Dementia in the Philippines
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Anlacan, Veeda Michelle M., Panganiban, Angelo Cedric F., Jamora, Roland Dominic G., Salido, Isabel Teresa O., Apuya, Romuel Aloizeus Z., Galecio, Bryan Andrei C., Tee, Michael L., Aguila, Maria Eliza R., Tee, Cherica A., Caro, Jaime D. L., Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Moita, Ana, editor, Bühler, Katja, editor, Ali, Hesham, editor, Deng, Ning, editor, Chouvarda, Ioanna, editor, Cabitza, Federico, editor, Fred, Ana, editor, and Gamboa, Hugo, editor
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- 2024
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4. Overcoming Barriers in International Telemedicine Education: A Mixed-Method Study in the Philippines
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Oga, Toru, Panganiban, Katherine, Kudo, Kuriko, Celero, Jocelyn, Ueda, Shintaro, Tomimatsu, Shunta, Domino, Jeffrey, Moriyama, Tomohiko, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Barbosa, Simone Diniz Junqueira, Editorial Board Member, Chen, Phoebe, Editorial Board Member, Cuzzocrea, Alfredo, Editorial Board Member, Du, Xiaoyong, Editorial Board Member, Kara, Orhun, Editorial Board Member, Liu, Ting, Editorial Board Member, Sivalingam, Krishna M., Editorial Board Member, Slezak, Dominik, Editorial Board Member, Washio, Takashi, Editorial Board Member, Yang, Xiaokang, Editorial Board Member, Yuan, Junsong, Editorial Board Member, Ziefle, Martina, editor, Lozano, María Dolores, editor, and Mulvenna, Maurice, editor
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- 2024
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5. Individual Differences in Teaming with Artificial Intelligence, Robots, and Virtual Agents in the Workplace
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Matthews, Gerald, Hancock, Peter A., Szalma, James L., Lin, Jinchao, Panganiban, April Rose, Tuncdogan, Aybars, book editor, Acar, Oguz A., book editor, Volberda, Henk W., book editor, and de Ruyter, Ko, book editor
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- 2024
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6. The effect of swedish massage using ginger oil on chronic low back pain
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Syuhada Bahri, Sigit Nugroho, Sumaryanti Sumaryanti, Rizki Mulyawan, Agi Ginanjar, Tatpicha Pongsiri, and Teejay D. Panganiban
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swedish massage ,ginger oil ,chronic low back pain ,Sports ,GV557-1198.995 - Abstract
Background: Chronic low back pain is one of the musculoskeletal health problems that is common in society, including athletes. Chronic low back pain occurs in people in various countries, including Indonesia, with estimates that they experience pain that lasts approximately 24 hours for 3 months or more and often occurs at the age of 20-40 years. Disorders found in chronic low back pain sufferers usually experience pain in the lower back area. By using Swedish massage, which is a massage method to relax muscles, reduce pain and improve blood circulation, plus the use of ginger oil, which is a formulation commonly used to relieve pain and also as aromatherapy, can reduce the problem of chronic lower back pain. Objective: The aim of this study was to test the effect of Swedish massage using ginger oil on chronic low back pain. Methods: The research method uses experiments with a one-group pretest-posttest design. There were 7 participants taken using incidental sampling. The research instrument used the Visual Analogue Scale. The data analysis technique uses descriptive statistics and paired samples t test. Results: The research results obtained tcount = 6.33 with Sig. 0.00 < 0.05 which means there is an influence of SM using ginger oil on CLBP. Conclusion: This research concluded that there was an effect of Swedish massage using ginger oil on chronic low back pain. Further research with more participants is needed. Thus, the research results can be generalized, especially to women who have not been able to reveal anything in this research.
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- 2024
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7. Educators apply new teaching strategies despite initial attributions of autistic students controllability of their behaviors.
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Panganiban, Jonathan and Kasari, Connie
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JASPER ,attribution theory ,autism ,educator training ,joint engagement ,preschool - Abstract
Autistic children are less likely to be jointly engaged with a play partner than nonautistic children, negatively impacting social communication development. Promoting joint engagement during play can be an important target for educators of autistic students, but educator perceptions of autistic students may affect their interactions with students. This secondary data analysis investigated educator perceptions of the behaviors of their autistic students, their relationship on educator behavior, and their relationship on the implementation of an intervention promoting joint engagement. Participants included 66 autistic preschool students, and twelve educators from six preschools. Schools were randomized to educator training or a waitlist. Before training, educators rated their students controllability over autism related behaviors. To observe educator behavior, they were filmed playing for ten minutes with students, before and after receiving training. Ratings of controllability were positively correlated with cognitive scores, and negatively correlated with ADOS (Autism Diagnostic Observation Schedule) comparison scores. Furthermore, educator ratings of controllability predicted joint engagement strategies used by educators during play. Educators tended to use strategies promoting joint engagement for students perceived as more able to control their autism spectrum disorder behavior. Among educators that received JASPER (Joint Attention, Symbolic Play, Engagement, and Regulation) training, ratings of controllability did not predict changes in strategy scores after training. Educators were able to learn and implement new joint engagement strategies despite their initial perceptions.
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- 2023
8. Super responders: Predicting language gains from JASPER among limited language children with autism spectrum disorder.
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Panganiban, Jonathan and Kasari, Connie
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JASPER ,data-driven techniques ,intervention early ,intervention-behavioral ,language ,machine learning ,responders ,treatment research ,Attention ,Autism Spectrum Disorder ,Child ,Child ,Preschool ,Early Intervention ,Educational ,Humans ,Language ,Play and Playthings - Abstract
Early intervention can provide a great benefit for children with autism spectrum disorder (ASD). However, no single intervention is effective for all children. Even when an intervention is effective overall, individual child response varies. Some children make incredible progress, and others make slow or no progress. Therefore, it is important that the field move towards developing methods to personalize intervention. Operationalizing meaningful change and predicting intervention response are critical steps in designing systematic and personalized early intervention. The present research used improvement in expressive language to group children that received a targeted social communication early intervention, Joint Attention, Symbolic Play, Engagement, and Regulation (JASPER), into super responders and slow responders. Using baseline data from traditional standardized assessments of cognition and behavioral data from validated experimental measures of play and social communication, we used conditional inference tree models to predict responder status. From a sample of 99 preschool age, limited language children with ASD, play diversity was the most significant predictor of responder status. Children that played functionally with a wider variety of toys had increased odds of being a super responder to JASPER. A combination of lower play diversity and impairments in fine motor abilities increased the odds of children being slow responders to JASPER. Results from the present study can inform future efforts to individualize intervention and systematic approaches to augmenting treatment in real time. LAY SUMMARY: To help us answer the question of for whom an intervention works best, we examined 99 children, age three to five, who qualified as being limited spoken language communicators, and received a targeted intervention for social communication and language. We used child characteristics before intervention to predict which children would improve their language the most and found that the ability to play appropriately with a wider variety of toys predicted the best improvements in expressive language. These findings will help better inform future work to individualize intervention based on the unique needs of each child.
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- 2022
9. Two new mouse alleles of Ocm and Slc26a5
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Lachgar-Ruiz, Marìa, Ingham, Neil J, Martelletti, Elisa, Chen, Jing, James, Elysia, Panganiban, Clarisse, Lewis, Morag A, and Steel, Karen P
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- 2024
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10. Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures
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Jiwon Lee, Xiangning Xue, Emily Au, William B. McIntyre, Roshanak Asgariroozbehani, Kristoffer Panganiban, George C. Tseng, Maria Papoulias, Emily Smith, Jonathan Monteiro, Divia Shah, Kateryna Maksyutynska, Samantha Cavalier, Emril Radoncic, Femin Prasad, Sri Mahavir Agarwal, Robert Mccullumsmith, Zachary Freyberg, Ryan W. Logan, and Margaret K. Hahn
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may therefore be intrinsic to psychosis spectrum disorders (PSDs), independent of the metabolic effects of APs. However, the potential biological pathways that overlap between PSDs and dysglycemic states remain to be identified. Using meta-analytic approaches of transcriptomic datasets, we investigated whether AP-naive FEP patients share overlapping gene expression signatures with non-psychiatrically ill early dysglycemia individuals. We meta-analyzed peripheral transcriptomic datasets of AP-naive FEP patients and non-psychiatrically ill early dysglycemia subjects to identify common gene expression signatures. Common signatures underwent pathway enrichment analysis and were then used to identify potential new pharmacological compounds via Integrative Library of Integrated Network-Based Cellular Signatures (iLINCS). Our search results yielded 5 AP-naive FEP studies and 4 early dysglycemia studies which met inclusion criteria. We discovered that AP-naive FEP and non-psychiatrically ill subjects exhibiting early dysglycemia shared 221 common signatures, which were enriched for pathways related to endoplasmic reticulum stress and abnormal brain energetics. Nine FDA-approved drugs were identified as potential drug treatments, of which the antidiabetic metformin, the first-line treatment for type 2 diabetes, has evidence to attenuate metabolic dysfunction in PSDs. Taken together, our findings support shared gene expression changes and biological pathways associating PSDs with dysglycemic disorders. These data suggest that the pathobiology of PSDs overlaps and potentially contributes to dysglycemia. Finally, we find that metformin may be a potential treatment for early metabolic dysfunction intrinsic to PSDs.
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- 2024
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11. Pediatric parosteal osteosarcoma of the distal radius causing extensive erosive mass effect of the adjacent ulna: a case report
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Andrea Perloff, SeHoon Park, Robert Panganiban, and John deVries
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Parosteal Osteosarcoma ,Pediatric ,Distal Radius ,Ulna ,MDM2 gene amplification ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Introduction Parosteal osteosarcomas are low-grade bony malignancies that are treated primarily with surgical resection and reconstruction. This report discusses a unique case of a pediatric patient who presented with a parosteal osteosarcoma of the distal radius causing extensive erosive mass effect and growth disturbance of the adjacent ulna. Likely due to their slow-growing nonaggressive nature, parosteal osteosarcomas have not been previously described to abut adjacent bony structures through direct contact. The patient presented in a significantly delayed manner due to social circumstances, inadvertently revealing this novel behavior. This report reviews this rare case and describes the current understanding of this tumor. Case presentation The patient is a 13-year-old male who presented with a parosteal osteosarcoma of his distal radius. He presented with a palpable wrist mass and wrist stiffness. He presented in a delayed manner with advanced local disease due to social factors. Imaging revealed an osseous radial mass that abutted the ulna and likely stunted its growth. The patient ultimately underwent complex resection and allograft reconstruction of both his distal radius and ulna. Intraoperative pathology was confirmed to have negative tumor margins. Allograft reconstruction of the radius and ulna was performed utilizing patient-specific custom cutting guides. At the 6-month postoperative visit, the patient had no recurrence of the mass, minimal pain, and had almost regained range of motion of the extremities. Clinical radiographs at the 6-month postoperative visit demonstrated allograft incorporation. Conclusions A previously unreported case of pediatric parosteal osteosarcoma of the distal radius with erosion of the adjacent ulna through direct contact is presented. The challenges in and the importance of arriving at a definitive diagnosis in a timely manner for the proper treatment of this malignancy are emphasized.
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- 2023
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12. A Randomized Noninferiority Trial to Compare Enteral to Parenteral Phosphate Replacement on Biochemistry, Waste, and Environmental Impact and Healthcare Cost in Critically Ill Patients With Mild to Moderate Hypophosphatemia*
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Nguyen, Chinh D., Panganiban, Haustine P., Fazio, Timothy, Karahalios, Amalia, Ankravs, Melissa J., MacIsaac, Christopher M., Rechnitzer, Thomas, Arno, Lucy, Tran-Duy, An, McAlister, Scott, Ali Abdelhamid, Yasmine, and Deane, Adam M.
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- 2024
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13. Peripheral Lipid Signatures, Metabolic Dysfunction, and Pathophysiology in Schizophrenia Spectrum Disorders
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Sally Wu, Kristoffer J. Panganiban, Jiwon Lee, Dan Li, Emily C.C. Smith, Kateryna Maksyutynska, Bailey Humber, Tariq Ahmed, Sri Mahavir Agarwal, Kristen Ward, and Margaret Hahn
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schizophrenia ,psychosis ,lipids ,lipidomics ,antipsychotics ,metabolic dysfunction ,Microbiology ,QR1-502 - Abstract
Metabolic dysfunction is commonly observed in schizophrenia spectrum disorders (SSDs). The causes of metabolic comorbidity in SSDs are complex and include intrinsic or biological factors linked to the disorder, which are compounded by antipsychotic (AP) medications. The exact mechanisms underlying SSD pathophysiology and AP-induced metabolic dysfunction are unknown, but dysregulated lipid metabolism may play a role. Lipidomics, which detects lipid metabolites in a biological sample, represents an analytical tool to examine lipid metabolism. This systematic review aims to determine peripheral lipid signatures that are dysregulated among individuals with SSDs (1) with minimal exposure to APs and (2) during AP treatment. To accomplish this goal, we searched MEDLINE, Embase, and PsychINFO databases in February 2024 to identify all full-text articles written in English where the authors conducted lipidomics in SSDs. Lipid signatures reported to significantly differ in SSDs compared to controls or in relation to AP treatment and the direction of dysregulation were extracted as outcomes. We identified 46 studies that met our inclusion criteria. Most of the lipid metabolites that significantly differed in minimally AP-treated patients vs. controls comprised glycerophospholipids, which were mostly downregulated. In the AP-treated group vs. controls, the significantly different metabolites were primarily fatty acyls, which were dysregulated in conflicting directions between studies. In the pre-to-post AP-treated patients, the most impacted metabolites were glycerophospholipids and fatty acyls, which were found to be primarily upregulated and conflicting, respectively. These lipid metabolites may contribute to SSD pathophysiology and metabolic dysfunction through various mechanisms, including the modulation of inflammation, cellular membrane permeability, and metabolic signaling pathways.
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- 2024
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14. Educators Apply New Teaching Strategies Despite Initial Attributions of Autistic Students' Controllability of Their Behaviors
- Author
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Panganiban, Jonathan and Kasari, Connie
- Abstract
Autistic children are less likely to be jointly engaged with a play partner than nonautistic children, negatively impacting social communication development. Promoting joint engagement during play can be an important target for educators of autistic students, but educator perceptions of autistic students may affect their interactions with students. This secondary data analysis investigated educator perceptions of the behaviors of their autistic students, their relationship on educator behavior, and their relationship on the implementation of an intervention promoting joint engagement. Participants included 66 autistic preschool students, and twelve educators from six preschools. Schools were randomized to educator training or a waitlist. Before training, educators rated their students' controllability over autism related behaviors. To observe educator behavior, they were filmed playing for ten minutes with students, before and after receiving training. Ratings of controllability were positively correlated with cognitive scores, and negatively correlated with ADOS (Autism Diagnostic Observation Schedule) comparison scores. Furthermore, educator ratings of controllability predicted joint engagement strategies used by educators during play. Educators tended to use strategies promoting joint engagement for students perceived as more able to control their autism spectrum disorder behavior. Among educators that received JASPER (Joint Attention, Symbolic Play, Engagement, and Regulation) training, ratings of controllability did not predict changes in strategy scores after training. Educators were able to learn and implement new joint engagement strategies despite their initial perceptions.
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- 2023
- Full Text
- View/download PDF
15. Understanding Factors Linked to Adolescent Pregnancy: A Review of the Literature
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Modesto, Olivia Panganiban
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The adolescent pregnancy rate in the United States is the highest among industrialized nations. It is important for professionals working with pregnant minors and adolescent mothers to understand the factors associated with adolescent pregnancy to avoid forming judgmental and negative attitudes towards this population. The purpose of this article is to outline the factors stated in the academic literature, that it may serve as a reference for professionals working with this population. The scientific literature underscores that multiple factors interact to influence adolescent sexual behavior, which may result to adolescent pregnancy. Understanding these factors with adolescent childbearing allows for a broader perspective and prevents simplistic thinking on a complex phenomenon.
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- 2020
16. Supporting Peer Engagement for Low-Income Preschool Students with Autism Spectrum Disorder during Academic Instruction: A Pilot Randomized Trial
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Panganiban, Jonathan L., Shire, Stephanie Y., Williams, Justin, and Kasari, Connie
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Schools are the portal through which many children with autism spectrum disorder access early intervention. Collaborating with teachers can be an effective way to implement evidence-based practices. In this study, teachers learned to embed strategies from the Joint Attention, Symbolic Play, Engagement, and Regulation intervention into the standard preschool curriculum. Twelve schools with special education preschool classrooms for students with moderate to severe disabilities from under-resourced neighborhoods were randomized to augment their curriculum with Joint Attention, Symbolic Play, Engagement, and Regulation strategies or continue the standard curriculum. Teachers' strategy implementation, children's time on task, and social communication were examined before and after completing the intervention phase. Teachers in the Joint Attention, Symbolic Play, Engagement, and Regulation group implemented more Joint Attention, Symbolic Play, Engagement, and Regulation strategies than the control group after the intervention phase. Children in both groups increased time on task during teacher-led small group instruction. Children in the Joint Attention, Symbolic Play, Engagement, and Regulation group were more likely to be engaged with peers during small group instruction at the end of the intervention phase. Children from both groups improved in standardized measures of joint attention, requesting, expressive language, and receptive language. Training teachers to embed Joint Attention, Symbolic Play, Engagement, and Regulation strategies into small group instruction can help facilitate peer engagement, providing children more opportunities for peer socialization.
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- 2022
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17. Development in an environmentally critical coastal area: The risk perception on natural hazards and the New Manila International Airport by fishing communities in Taliptip, Philippines
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Catane, Sandra G., Flora, John Romel R., Carag, John Warner M., Capino, Jethro B., Go, Chatty M., and Panganiban, Alfred Louie L.
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- 2024
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18. Guess Who's Coming to Clinic? Companions in a Pediatric Urology Clinic
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Mendez, Meridiana, Panganiban, Kurt, and Kieran, Kathleen
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- 2024
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19. Pediatric parosteal osteosarcoma of the distal radius causing extensive erosive mass effect of the adjacent ulna: a case report
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Perloff, Andrea, Park, SeHoon, Panganiban, Robert, and deVries, John
- Published
- 2023
- Full Text
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20. Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness
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Panganiban, Ronald Allan M., Yang, Zhiping, Sun, Maoyun, Park, Chan Young, Kasahara, David I., Schaible, Niccole, Krishnan, Ramaswamy, Kho, Alvin T., Israel, Elliot, Hershenson, Marc B., Weiss, Scott T., Himes, Blanca E., Fredberg, Jeffrey J., Tantisira, Kelan G., Shore, Stephanie A., and Lu, Quan
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- 2023
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21. Facing the digital frontier: exploring user acceptance of electronic health records in an urban, rural and remote setting in the Philippines
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Antonio L Dans, Leonila F Dans, Carol Stephanie C Tan-Lim, Ysabela Calderon, Regine Ynez H De Mesa, Noleen Marie C Fabian, Mia P Rey, Josephine T Sanchez, Cara Lois T Galingana, Nannette Bernal-Sundiang, Ray U Casile, Janelle Micaela S Panganiban, and Mark Anthony U Javelosa
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Medicine (General) ,R5-920 - Abstract
Objectives A thorough understanding of user needs and behavioural intent-to-use underpins the development of a responsive health information system. This study aimed to examine health workers’ intent-to-use an electronic health record (EHR) system in an urban, rural and remote setting in the Philippines.Methods Following the Unified Theory of Acceptance and Use of Technology framework, user acceptance and the factors influencing intent-to-use the EHR were examined through a self-administered questionnaire. A total of 128 EHR users, comprising physicians, nurses, midwives, barangay health workers and administrative staff, were surveyed. Median scores for each domain were compared across the sites using the Kruskal-Wallis test. Ridge regression analysis was used to identify factors associated with behavioural intent-to-use.Results Over 94% of users across all sites reported their intent-to-use the EHR in the near future. Of the seven predictor variables examined, only self-efficacy was found to be significantly associated with behavioural intent-to-use. Intent-to-use the EHR increased by 31% (p=0.007) for each unit increase in self-efficacy score among participants.Discussion Acceptance was high across the three sites, with self-efficacy being a predictor of intent-to-use the technology. This suggests that users are more likely to adopt an EHR if they believe they have the capacity to successfully navigate the technology and perform their designated tasks with it.Conclusion Co-producing interventions with primary care providers is crucial in sustaining EHR systems. Rather than developing a technology based on the surveillance needs of policymakers, an EHR developed from the grassroots was shown to be well-received by end-users.
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- 2024
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22. Bees display limited acclimation capacity for heat tolerance
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Victor H. Gonzalez, Natalie Herbison, Gabriela Robles Perez, Trisha Panganiban, Laura Haefner, Thomas Tscheulin, Theodora Petanidou, and John Hranitz
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critical thermal maximum ,climate change ,heat weaves ,heat hardening ,heat priming ,Science ,Biology (General) ,QH301-705.5 - Published
- 2024
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23. Promoting equitable and patient-centred care: an analysis of patient satisfaction in urban, rural and remote primary care sites in the Philippines
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Antonio L Dans, Leonila F Dans, Carol Stephanie C Tan-Lim, Regine Ynez H De Mesa, Noleen Marie C Fabian, Mia P Rey, Josephine T Sanchez, Cara Lois T Galingana, Ray U Casile, Maria Rhodora N Aquino, Johanna Faye E Lopez, Janelle Micaela S Panganiban, Arianna Maever Loreche, Romelei Camiling-Alfonso, Mark Anthony U Javelosa, Jose Rafael A Marfori, and Ramon Pedro Paterno
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Medicine (General) ,R5-920 - Abstract
Objectives This study measured changes in patient satisfaction levels before and after the introduction of primary care system strengthening interventions in urban, rural, and remote sites in the Philippines.Methods A previously validated 16-item questionnaire was distributed to 200 patients per site before implementation of interventions and to a different set of 200 patients 1 year after implementation. We compared the percentage change in highly satisfied patients per site before and after implementing interventions using a two-proportion Z-test.Results The urban site had a significant increase in patient satisfaction in 13 survey items, which corresponded to the domains of healthcare availability, service efficiency, technical competency and health communication. The rural site had a significant increase in six survey items, which corresponded to the domains of service efficiency, environment, location, health communication and handling. The remote site had a decrease in patient satisfaction in 10 survey items, with a significant increase in only 4 items under the domains of healthcare availability and handling.Conclusion Our findings support the ‘inverse equity hypothesis’, where well-resourced urban communities quickly adopt complex health interventions while rural and remote settings experience delays in effectively meeting patient needs and system demands. Extended intervention periods and targeted strategies may be necessary to impact patient satisfaction in underserved areas considerably.
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- 2024
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24. Utility of Postoperative Phone Calls in Reducing Unplanned Health Care Utilization
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Panganiban, Kurt, Mendez, Meridiana, Taylor, Amy, and Kieran, Kathleen
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- 2024
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25. Zika virus persistence in the male macaque reproductive tract
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Ball, Erin E, Pesavento, Patricia A, Van Rompay, Koen KA, Keel, M Kevin, Singapuri, Anil, Gomez-Vazquez, Jose P, Dudley, Dawn M, O’Connor, David H, Breitbach, Meghan E, Maness, Nicholas J, Schouest, Blake, Panganiban, Antonito, and Coffey, Lark L
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Reproductive Medicine ,Medical Microbiology ,Biomedical and Clinical Sciences ,Biological Sciences ,Contraception/Reproduction ,Infertility ,Infectious Diseases ,Prostate Cancer ,Urologic Diseases ,Cancer ,2.2 Factors relating to the physical environment ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Reproductive health and childbirth ,Good Health and Well Being ,Animals ,Genitalia ,Male ,Humans ,Macaca ,Male ,RNA ,Semen ,Zika Virus ,Zika Virus Infection ,Medical and Health Sciences ,Tropical Medicine ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Zika virus (ZIKV) is unique among mosquito-borne flaviviruses in that it is also vertically and sexually transmitted by humans. The male reproductive tract is thought to be a ZIKV reservoir; however, the reported magnitude and duration of viral persistence in male genital tissues vary widely in humans and non-human primate models. ZIKV tissue and cellular tropism and potential effects on male fertility also remain unclear. The objective of this study was to resolve these questions by analyzing archived genital tissues from 51 ZIKV-inoculated male macaques and correlating data on plasma viral kinetics, tissue tropism, and ZIKV-induced pathological changes in the reproductive tract. We hypothesized that ZIKV would persist in the male macaque genital tract for longer than there was detectable viremia, where it would localize to germ and epithelial cells and associate with lesions. We detected ZIKV RNA and infectious virus in testis, epididymis, seminal vesicle, and prostate gland. In contrast to prepubertal males, sexually mature macaques were significantly more likely to harbor persistent ZIKV RNA or infectious virus somewhere in the genital tract, with detection as late as 60 days post-inoculation. ZIKV RNA localized primarily to testicular stem cells/sperm precursors and epithelial cells, including Sertoli cells, epididymal duct epithelium, and glandular epithelia of the seminal vesicle and prostate gland. ZIKV infection was associated with microscopic evidence of inflammation in the epididymis and prostate gland of sexually mature males, pathologies that were absent in uninfected controls, which could have significant effects on male fertility. The findings from this study increase our understanding of persistent ZIKV infection which can inform risk of sexual transmission during assisted reproductive therapies as well as potential impacts on male fertility.
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- 2022
26. Analysis of Virtual Reality Therapy Game Prototype for Persons Living with Dementia in the Philippines.
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Veeda Michelle M. Anlacan, Roland Dominic G. Jamora, Angelo Cedric F. Panganiban, Isabel Teresa O. Salido, Romuel Aloizeus Z. Apuya, Bryan Andrei C. Galecio, Michael L. Tee, Maria-Eliza R. Aguila, Cherica A. Tee, and Jaime D. L. Caro
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- 2023
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27. An Indoor Smart Farm Sensor Node with Energy Harvesting System.
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Bryan Christopher P. Bascos, Eric John L. Panganiban, Marc D. Rosales, Paul Jason Co, and John Richard E. Hizon
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- 2023
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28. A Quantitative Analysis of Barriers to International Telemedicine Education: The Case of the Philippines.
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Toru Oga, Katherine Panganiban, Kuriko Kudo, Jocelyn Celero, Shintaro Ueda, Shunta Tomimatsu, Jeffrey Domino, and Tomohiko Moriyama
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- 2023
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29. Exclusive Values, Religious, and Moral Education: An Appeal for Philosophical Pedagogy for the Sake of Inclusivity
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Marquez, Leander Penaso, Florendo, Kimberly Panganiban, Rezaei, Nima, Editor-in-Chief, Mancenido-Bolaños, Marella Ada V., editor, Alvarez-Abarejo, Cathlyne Joy P., editor, and Marquez, Leander Penaso, editor
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- 2023
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30. Integrative Health Therapies for Pediatric IBD
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Vellanki, Srisindu, Panganiban, Jennifer, Erlichman, Jessi, Mascarenhas, Maria, Mamula, Petar, editor, Kelsen, Judith R., editor, Grossman, Andrew B., editor, Baldassano, Robert N., editor, and Markowitz, Jonathan E., editor
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- 2023
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31. Design Strategies on Virtual Reality for Cognitive Monitoring of Older Persons
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Panganiban, Angelo Cedric F., Caro, Jaime D. L., Juayong, Richelle Ann B., Anlacan, Veeda Michelle M., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Krouska, Akrivi, editor, Troussas, Christos, editor, and Caro, Jaime, editor
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- 2023
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32. Central insulin dysregulation in antipsychotic-naïve first-episode psychosis: In silico exploration of gene expression signatures
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Lee, Jiwon, Xue, Xiangning, Au, Emily, McIntyre, William B., Asgariroozbehani, Roshanak, Tseng, George C., Papoulias, Maria, Panganiban, Kristoffer, Agarwal, Sri Mahavir, Mccullumsmith, Robert, Freyberg, Zachary, Logan, Ryan W., and Hahn, Margaret K.
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- 2024
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33. Beyond Limits: A Case of Progressive Leiomyosarcoma of the Mandible
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Mel Valerie Cruz Ordinario, May Sabando, and Anna Marie Pascual Panganiban
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leiomyosarcoma ,mandible ,progressive disease ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Leiomyosarcoma (LMS) is a rare malignancy which develops from the smooth muscles. It constitutes about 3 to 10% of all sarcomas in the head and neck area. Furthermore, it is extremely rare in the area of the mouth and jaws due to the rarity of smooth muscle in these areas. Spindle cells with visible smooth muscle differentiation, distinct features of atypia and presence of actin and desmin in Immunohistochemical (IHC) stains are characteristic of LMS. The common pattern of spread is similar with other sarcomas, involving the lung and rarely the lymphatics. Surgery, Radiotherapy and Chemotherapy have been described as standard forms of management. The prognosis is usually poor as rate of local, regional and distant metastasis is high. In this paper, we present a case of a 23 year-old female who presented with Leiomyosarcoma of the mandible. She remained to have good performance status and was able to undergo multiple lines of treatment for progressive disease prior to her demise.
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- 2023
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34. Acquiring skills in basketball through observational learning
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Teejay D. Panganiban and Michael H. San Miguel
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acquisition ,observational learning ,basketball ,general weighted average (gwa) ,Sports ,GV557-1198.995 - Abstract
With the ongoing COVID-19 pandemic requiring us to practice social or physical distancing, the concept of observational learning has become particularly relevant. This learning process involves observing others, retaining the information, and replicating the observed behaviors later. This research determined the skill acquisition in Basketball through observational learning of pre-service teachers at Batangas State University JPLPC-Malvar to determine its implications for teaching physical education. It specifically addressed the respondents' profile in terms of sex, program, GWA, and socio-economic status significant relationship between the respondents' profile and their skill acquisition in Basketball through observational learning. This descriptive-correlational study was conducted to assess the 89 students enrolled in the College of Teacher Education program at the Batangas State University JPLPC-Malvar campus. An adequate number of respondents and an appropriate sampling technique are adopted to produce a valid and reliable result. Using a self-made questionnaire and appropriate statistical measures, the results revealed that the respondents are greatly female, mostly from Bachelor of Secondary Education, belong to the Superior Group, and have a middle income. Chi-Square revealed that sex, program, GWA, and socio-economic status have significant relationships when correlated to their encountered challenges. The above-mentioned findings recommend using multimedia or video demonstrating skills in physical education classes to train the students' skills and strengthen the use of observational learning and conducting a webinar that focuses on how we can learn Basketball through observational learning.
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- 2023
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35. Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy
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McGeachie, Michael J, Sordillo, Joanne E, Dahlin, Amber, Wang, Alberta L, Lutz, Sharon M, Tantisira, Kelan G, Panganiban, Ronald, Lu, Quan, Sajuthi, Satria, Urbanek, Cydney, Kelly, Rachel, Saef, Benjamin, Eng, Celeste, Oh, Sam S, Kho, Alvin T, Croteau-Chonka, Damien C, Weiss, Scott T, Raby, Benjamin A, Mak, Angel CY, Rodriguez-Santana, Jose R, Burchard, Esteban G, Seibold, Max A, and Wu, Ann Chen
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Asthma ,Biotechnology ,Genetics ,Clinical Research ,Human Genome ,Lung ,Aetiology ,2.1 Biological and endogenous factors ,Respiratory ,Administration ,Inhalation ,Adolescent ,Adrenal Cortex Hormones ,Adult ,Age Factors ,Child ,Chromosomal Proteins ,Non-Histone ,Cohort Studies ,Female ,Gene Expression ,Hispanic or Latino ,Humans ,Male ,Middle Aged ,Treatment Outcome ,Young Adult ,Cardiorespiratory Medicine and Haematology ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundGlobal gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment-specific context.MethodsWe used gene expression data from CD4+ lymphocytes in the Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE), an open-access collection of subjects participating in genetic studies of asthma with available gene expression data. Replication population participants were Puerto Rico islanders recruited as part of the ongoing Genes environments & Admixture in Latino Americans (GALA II), who provided nasal brushings for transcript sequencing. The main outcome measure was chronic asthma control as derived by questionnaires. Genomic associations were performed using regression of chronic asthma control score on gene expression with age in years as a covariate, including a multiplicative interaction term for gene expression times age.ResultsThe SMARCD1 gene (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1) interacted with age to influence chronic asthma control on inhaled corticosteroids, with a doubling of expression leading to an increase of 1.3 units of chronic asthma control per year (95% CI [0.86, 1.74], p = 6 × 10- 9), suggesting worsening asthma control with increasing age. This result replicated in GALA II (p = 3.8 × 10- 8). Cellular assays confirmed the role of SMARCD1 in glucocorticoid response in airway epithelial cells.ConclusionFocusing on age-dependent factors may help identify novel indicators of asthma medication response. Age appears to modulate the effect of SMARCD1 on asthma control with inhaled corticosteroids.
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- 2020
36. Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
- Author
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Abraham, James, Adkisson, Michael, Albert, Marisa, Altamirano, Luz Torres, Alvarenga, Bonny, Anderson, Matthew L., Anderson, Evan J., Arnett, Azlann, Asashima, Hiromitsu, Atkinson, Mark A., Baden, Lindsey R., Barton, Brenda, Beach, Katherine, Beagle, Elizabeth, Becker, Patrice M., Bell, Matthew R., Bernui, Mariana, Bime, Christian, Boddapati, Arun Kumar, Booth, J. Leland, Borresen, Brittney, Brakenridge, Scott C., Bristow, Laurel, Bryant, Robert, Calfee, Carolyn S., Carreño, Juan Manuel, Carrillo, Sidney, Chak, Suzanna, Chang, Iris, Connors, Jennifer, Conway, Michelle, Corry, David B., Cowan, David, Croen, Brett, Dela Cruz, Charles S., Cusimano, Gina, Eaker, Lily, Edwards, Carolyn, Ehrlich, Lauren I.R., Elashoff, David, Erickson, Heidi, Erle, David J., Farhadian, Shelli, Farrugia, Keith, Fatou, Benoit, Fernandes, Andrea, Fernandez-Sesma, Ana, Fragiadakis, Gabriela K., Furukawa, Sara, Geltman, Janelle N., Ghale, Rajani, Bermúdez González, Maria Carolina, Goonewardene, I. Michael, Guerrero, Estella Sanchez, Guirgis, Faheem W., Hafler, David A., Hamilton, Sydney, Harris, Paul, Hayati, Arash Nemati, Hendrickson, Carolyn M., Agudelo Higuita, Nelson I., Hodder, Thomas, Holland, Steven M., Hough, Catherine L., Huerta, Christopher, Hurley, Kerin C., Hutton, Scott R., Iwasaki, Akiko, Jauregui, Alejandra, Jha, Meenakshi, Johnson, Brandi, Joyner, David, Kangelaris, Kirsten N., Kelly, Geoffrey, Khalil, Zain, Khan, Zenab, Kheradmand, Farrah, Kim, James N., Kimura, Hiroki, Ko, Albert I., Kohr, Bernard, Kraft, Monica, Krummel, Matthew, Kutzler, Michele A., Lasky-Su, Jessica, Lee, Serena, Lee, Deanna, Leipold, Michael, Lentucci, Claudia, Leroux, Carolyn, Lin, Edward, Liu, Shanshan, Love, Christina, Lu, Zhengchun, Maliskova, Lenka, Manning, Brittany Roth, Manohar, Monali, Martens, Mark, McComsey, Grace A., McEnaney, Kerry, McLin, Renee, Melamed, Esther, Melnyk, Nataliya, Mendez, Kevin, Messer, William B., Metcalf, Jordan P., Michelotti, Gregory, Mick, Eran, Mohanty, Subhasis, Mosier, Jarrod, Mulder, Lubbertus C.F., Murphy, Maimouna, Nadeau, Kari R.C., Nelson, Ebony, Nelson, Allison, Nguyen, Viet, Oberhaus, Jordan, Panganiban, Bernadine, Pellegrini, Kathryn L., Pickering, Harry C., Powell, Debra L., Presnell, Scott, Pulendran, Bali, Rahman, Adeeb H., Rashid, Ahmad Sadeed, Raskin, Ariel, Reed, Elaine F., Ribeiro, Susan Pereira, Rivera, Adreanne M., Rogers, Jacob E., Rogers, Angela, Rogowski, Brandon, Rooks, Rebecca, Rosenberg-Hasson, Yael, Rothman, Jessica, Rousseau, Justin F., Salehi-Rad, Ramin, Saluvan, Mehmet, Samaha, Hady, Schaenman, Joanna, Schunk, Ron, Semenza, Nicholas C., Sen, Subha, Sevransky, Jonathan, Seyfert-Margolis, Vicki, Shaheen, Tanzia, Shaw, Albert C., Sieg, Scott, Siegel, Sarah A.R., Sigal, Natalia, Siles, Nadia, Simmons, Brent, Simon, Viviana, Singh, Gagandeep, Sinko, Lauren, Smith, Cecilia M., Smolen, Kinga K., Song, Li-Zhen, Srivastava, Komal, Sullivan, Peter, Syphurs, Caitlin, Tcheou, Johnstone, Tegos, George P., Tharp, Greg K., Tong, Alexandra, Tsitsiklis, Alexandra, Ungaro, Ricardo F., Vaysman, Tatyana, Viode, Arthur, Vita, Randi, Wang, Xiaomei, Ward, Alyssa, Ward, Dawn C., Willmore, Andrew, Woloszczuk, Kyra, Wong, Kari, Woodruff, Prescott G., Xu, Leqi, van Haren, Simon, van de Guchte, Adriana, Zhao, Yujiao, Diray-Arce, Joann, Fourati, Slim, Doni Jayavelu, Naresh, Patel, Ravi, Maguire, Cole, Chang, Ana C., Dandekar, Ravi, Qi, Jingjing, Lee, Brian H., van Zalm, Patrick, Schroeder, Andrew, Chen, Ernie, Konstorum, Anna, Brito, Anderson, Gygi, Jeremy P., Kho, Alvin, Chen, Jing, Pawar, Shrikant, Gonzalez-Reiche, Ana Silvia, Hoch, Annmarie, Milliren, Carly E., Overton, James A., Westendorf, Kerstin, Cairns, Charles B., Rouphael, Nadine, Bosinger, Steven E., Kim-Schulze, Seunghee, Krammer, Florian, Rosen, Lindsey, Grubaugh, Nathan D., van Bakel, Harm, Wilson, Michael, Rajan, Jayant, Steen, Hanno, Eckalbar, Walter, Cotsapas, Chris, Langelier, Charles R., Levy, Ofer, Altman, Matthew C., Maecker, Holden, Montgomery, Ruth R., Haddad, Elias K., Sekaly, Rafick P., Esserman, Denise, Ozonoff, Al, Augustine, Alison D., Guan, Leying, Peters, Bjoern, and Kleinstein, Steven H.
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- 2023
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37. Actinotignum schaalii Abscess in a Patient with Common Variable Immunodeficiency
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Panganiban, Christine Marie and Gupta, Sudhir
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Microbiology ,Medical Microbiology ,Biomedical and Clinical Sciences ,Biological Sciences ,Urologic Diseases ,Infectious Diseases ,Infection ,Actinotignum schaalii ,common variable immunodeficiency ,abscess ,primary immunodeficiency ,Immunology ,Medical microbiology - Abstract
Actinotignum schaalii is an anaerobic, gram-positive commensal organism of the urogenital tract. A. schaalii typically causes urinary tract infections, predominantly in the elderly. Here, we describe the first case of A. schaalii infection presenting as cellulitis and abscess in a patient with common variable immunodeficiency. The patient was successfully treated with an incision and drainage and a prolonged antibiotic course. A. schaalii infection should be considered in sterile abscesses, and anaerobic cultures should be requested in the absence of positive routine cultures.
- Published
- 2020
38. Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness
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Ronald Allan M. Panganiban, Zhiping Yang, Maoyun Sun, Chan Young Park, David I. Kasahara, Niccole Schaible, Ramaswamy Krishnan, Alvin T. Kho, Elliot Israel, Marc B. Hershenson, Scott T. Weiss, Blanca E. Himes, Jeffrey J. Fredberg, Kelan G. Tantisira, Stephanie A. Shore, and Quan Lu
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Science - Abstract
The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway hyperresponsiveness in mice.
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- 2023
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39. The effect of interval training on athletic 100 meter running speed: a meta-analysis study
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Vindryani Septayasa, Supriatna Supriatna, Yulingga Nanda Hanief, and Teejay D. Panganiban
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interval training ,meta-analysis ,sprint ,Education (General) ,L7-991 - Abstract
This research on the effect of interval training on 100 meter running speed has been widely done in sports. Various researchers explain that interval training is very influential in increasing the speed of running 100 meters, but each study reports different results. This difference causes the need to conduct inclusive data analysis to provide comprehensive information about the importance of interval training to increase 100-meter running speed in athletic athletes. This method must be done by collecting data from research results indexed on Google Scholar by searching for research published in the range of 2010-2021. The search for the results of this study was carried out by entering two keywords, namely the first keyword "interval" AND "100 meter run" AND "journal" OR "journal" with the results found 224 articles and the second keyword is "interval" AND "100 meter sprint" with the results found 139 articles. Data on articles that already fit the study's inclusion and exclusion criteria were taken to determine the effect size (ES) and standard error (SE) values. The results of this study show the value of the RE estimate and FE model 11.243 junior high school criteria and the value of the RE estimate and FE model 9.786 athlete criteria which means that this interval training has a significant effect on the junior high school level and athletes who focus specifically on 100 meter running speed. This research is only limited to 100-meter sprints in junior high school students and athletes, it is recommended that future researchers examine other sports and other subjects.
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- 2022
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40. Design Strategies on Virtual Reality for Cognitive Monitoring of Older Persons.
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Angelo Cedric F. Panganiban, Jaime D. L. Caro, Richelle Ann B. Juayong, and Veeda Michelle M. Anlacan
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- 2022
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41. Application Design for a Virtual Reality Therapy Game for Patients with Behavioral and Psychological Symptoms of Dementia.
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Veeda Michelle M. Anlacan, Roland Dominic G. Jamora, Angelo Cedric F. Panganiban, Isabel Teresa O. Salido, Maria Evelyn V. Jacinto, Michael L. Tee, Maria-Eliza R. Aguila, Cherica A. Tee, and Jaime D. L. Caro
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- 2022
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42. The role of interest in athletics in promoting students’ home-based physical activities engagement amidst pandemic
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Teejay Dela Cueva Panganiban
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sports ,physical fitness ,home-based physical fitness ,physical education ,Sports ,GV557-1198.995 - Abstract
Sports and activity programs play a significant role in children's overall physical activity levels to allow them to benefit from participating in physical activity during the pandemic. The researcher seeks to provide guidelines that will benefit all students who participate in physical education. This study aimed to determine the interest in athletics and engagement in home-based physical fitness activities of pre-service physical education teachers at Batangas State University JPLPC-Malvar, to determine its implications for teaching physical education. It specifically addressed the respondents' level of interest in athletics, their engagement in home-based physical fitness activities, the significant relationship between the two variables, and suggested activities to increase respondents' interest in athletics through participation in home-based physical fitness activities. This descriptive-correlational study was conducted to assess 62 students enrolled in the Bachelor of Physical Education program at the Batangas State University JPLPC-Malvar campus. Using a self-made questionnaire and appropriate statistical measures, the obtained results revealed that the majority of respondents engage in home-based physical fitness activities; however, bodyweight training is more engaging than anaerobic exercise. The data also showed a significant relationship between athletic interest levels and home-based physical fitness activities. The majority of responders are pre-service physical education instructors. The recommended activities to increase respondents' interest in athletics can be accomplished through participation in home-based physical fitness activities.
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- 2022
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43. Incidence of cardiotoxicity after high cumulative dose of anthracyclines in adult patients with advanced soft tissue sarcomas: A systematic review and meta-analysis.
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Maravilla, Rachelle Diane Bautista, primary, Franco, Paula Isabel Gimena, additional, Alcala, Gale Rizzae Mercado, additional, Pilapil, John Christopher Agsalud, additional, Gorospe, Agnes Evangelista, additional, and Pascual-Panganiban, Anna Marie Mangune, additional
- Published
- 2024
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44. #2564 Terlipressin given by continuous infusion versus boluses in the treatment of hepatorenal syndrome: a systematic review and meta-analysis
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Villavicencio, Jayson, primary, Panganiban, Bea Regine, additional, Villanueva, Cary Amiel, additional, and Lao, Janice Jill, additional
- Published
- 2024
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45. Design Strategies on Virtual Reality for Cognitive Monitoring of Older Persons
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Panganiban, Angelo Cedric F., primary, Caro, Jaime D. L., additional, Juayong, Richelle Ann B., additional, and Anlacan, Veeda Michelle M., additional
- Published
- 2022
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46. Developmental screening and early intervention in a childcare setting for young children at risk for autism and other developmental delays: A feasibility trial
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Gulsrud, Amanda, Carr, Themba, Williams, Justin, Panganiban, Jonathan, Jones, Felica, Kimbrough, Jackie, Shih, Wendy, and Kasari, Connie
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Biomedical and Clinical Sciences ,Applied and Developmental Psychology ,Clinical and Health Psychology ,Neurosciences ,Psychology ,Intellectual and Developmental Disabilities (IDD) ,Health Services ,Prevention ,Brain Disorders ,Pediatric ,Mental Health ,Clinical Trials and Supportive Activities ,Clinical Research ,Autism ,Mental health ,Autism Spectrum Disorder ,Child ,Child Day Care Centers ,Child ,Preschool ,Developmental Disabilities ,Early Diagnosis ,Early Intervention ,Educational ,Feasibility Studies ,Female ,Humans ,Infant ,Los Angeles ,Male ,children ,early detection ,intervention-behavioral ,JASPER ,treatment research ,Clinical Sciences ,Developmental & Child Psychology ,Applied and developmental psychology ,Clinical and health psychology - Abstract
Efforts to decrease disparity in diagnosis and treatment for under-resourced children with developmental delays, such as autism spectrum disorder, have led to increased interest in developing programs in community settings. One potential setting that has already demonstrated feasibility in conducting universal screening is the childcare setting. The current study conducted developmental screening in a total of 116 children ages 16-80 months of age in an urban low-income community childcare center. Parents of 20 children who screened positive were enrolled in the intervention phase of the study, where children received a staff-delivered targeted early intervention or a waitlist control condition. Given the small and imbalanced sample sizes, confidence intervals from mixed effect models were used to measure changes across time for each group. Of the children who received treatment, there was an average increase in child initiated joint engagement, symbolic play, and language use. This study provides initial feasibility data for the implementation of a screening and early intervention program to service a predominantly low-resource and ethnically diverse population within the childcare system in a large metropolitan city. Autism Res 2019, 12: 1423-1433. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Identifying and delivering treatment services for young children with developmental delays, such as autism spectrum disorder, may be most successful in community settings, especially for those children from under-resourced areas. This study found preliminary evidence that the childcare setting is a good place to conduct screening and deliver early interventions for children at risk for autism and other developmental delays.
- Published
- 2019
47. Clinical Practice Approach to Nonalcoholic Fatty Liver Disease by Pediatric Gastroenterologists in the United States
- Author
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Shapiro, Warren L, Yu, Elizabeth L, Arin, Jennifer C, Murray, Karen F, Ali, Sabina, Desai, Nirav K, Xanthakos, Stavra A, Lin, Henry C, Alkhouri, Naim, Abdou, Reham, Abrams, Stephanie H, Butler, Megan W, Faasse, Sarah A, Gillis, Lynette A, Hadley, Timothy A, Jain, Ajay K, Kavan, Marianne, Kordy, Kattayoun, Lee, Peter, Panganiban, Jennifer, Pohl, John F, Potter, Carol, Rudolph, Bryan, Sundaram, Shikha S, Joshi, Shivali, Proudfoot, James A, Goyal, Nidhi P, Harlow, Kathryn E, Newton, Kimberly P, and Schwimmer, Jeffrey B
- Subjects
Digestive Diseases ,Clinical Research ,Nutrition ,Prevention ,Liver Disease ,Pediatric ,Pediatric Research Initiative ,Clinical Trials and Supportive Activities ,Chronic Liver Disease and Cirrhosis ,Management of diseases and conditions ,7.1 Individual care needs ,Metabolic and endocrine ,Child ,Female ,Gastroenterologists ,Gastroenterology ,Humans ,Male ,Non-alcoholic Fatty Liver Disease ,Pediatrics ,Practice Patterns ,Physicians' ,United States ,clinical practice ,nonalcoholic steatohepatitis ,obesity ,Medical and Health Sciences ,Gastroenterology & Hepatology - Abstract
ObjectivesNonalcoholic fatty liver disease (NAFLD) is common; however, no information is available on how pediatric gastroenterologists in the United States manage NAFLD. Therefore, study objectives were to understand how pediatric gastroenterologists in the US approach the management of NAFLD, and to identify barriers to care for children with NAFLD.MethodsWe performed structured one-on-one interviews to ascertain each individual pediatric gastroenterologist's approach to the management of NAFLD in children. Responses were recorded from open-ended questions regarding screening for comorbidities, recommendations regarding nutrition, physical activity, medications, and perceived barriers to care.ResultsResponse rate was 72.0% (486/675). Mean number of patients examined per week was 3 (standard deviation [SD] 3.5). Dietary intervention was recommended by 98.4% of pediatric gastroenterologists. Notably, 18 different dietary recommendations were reported. A majority of physicians provided targets for exercise frequency (72.6%, mean 5.6 days/wk, SD 1.6) and duration (69.9%, mean 40.2 minutes/session, SD 16.4). Medications were prescribed by 50.6%. Almost one-half of physicians (47.5%) screened for type 2 diabetes, dyslipidemia, and hypertension. Providers who spent more than 25 minutes at the initial visit were more likely to screen for comorbidities (P = 0.003). Barriers to care were reported by 92.8% with 29.0% reporting ≥3 barriers.ConclusionsThe majority of US pediatric gastroenterologists regularly encounter children with NAFLD. Varied recommendations regarding diet and exercise highlight the need for prospective clinical trials. NAFLD requires a multidimensional approach with adequate resources in the home, community, and clinical setting.
- Published
- 2019
48. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study
- Author
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Ozonoff, Al, Schaenman, Joanna, Jayavelu, Naresh Doni, Milliren, Carly E., Calfee, Carolyn S., Cairns, Charles B., Kraft, Monica, Baden, Lindsey R., Shaw, Albert C., Krammer, Florian, van Bakel, Harm, Esserman, Denise A., Liu, Shanshan, Sesma, Ana Fernandez, Simon, Viviana, Hafler, David A., Montgomery, Ruth R., Kleinstein, Steven H., Levy, Ofer, Bime, Chris, Haddad, Elias K., Erle, David J., Pulendran, Bali, Nadeau, Kari C., Davis, Mark M, Hough, Catherine L., Messer, William B., Higuita, Nelson I. Agudelo, Metcalf, Jordan P., Atkinson, Mark A., Brakenridge, Scott C., Corry, David, Kheradmand, Farrah, Ehrlich, Lauren I.R., Melamed, Esther, McComsey, Grace A., Sekaly, Rafick, Diray-Arce, Joann, Peters, Bjoern, Augustine, Alison D., Reed, Elaine F., McEnaney, Kerry, Barton, Brenda, Lentucci, Claudia, Saluvan, Mehmet, Chang, Ana C., Hoch, Annmarie, Albert, Marisa, Shaheen, Tanzia, Kho, Alvin T., Thomas, Sanya, Chen, Jing, Murphy, Maimouna D., Cooney, Mitchell, Presnell, Scott, Fragiadakis, Gabriela K., Patel, Ravi, Guan, Leying, Gygi, Jeremy, Pawar, Shrikant, Brito, Anderson, Khalil, Zain, Maguire, Cole, Fourati, Slim, Overton, James A., Vita, Randi, Westendorf, Kerstin, Salehi-Rad, Ramin, Leligdowicz, Aleksandra, Matthay, Michael A., Singer, Jonathan P., Kangelaris, Kirsten N., Hendrickson, Carolyn M., Krummel, Matthew F., Langelier, Charles R., Woodruff, Prescott G., Powell, Debra L., Kim, James N., Simmons, Brent, Goonewardene, I. Michael, Smith, Cecilia M., Martens, Mark, Mosier, Jarrod, Kimura, Hiroki, Sherman, Amy C., Walsh, Stephen R., Issa, Nicolas C., Dela Cruz, Charles, Farhadian, Shelli, Iwasaki, Akiko, Ko, Albert I., Chinthrajah, Sharon, Ahuja, Neera, Rogers, Angela J., Artandi, Maja, Siegel, Sarah A.R., Lu, Zhengchun, Drevets, Douglas A., Brown, Brent R., Anderson, Matthew L., Guirgis, Faheem W., Thyagarajan, Rama V., Rousseau, Justin F., Wylie, Dennis, Busch, Johanna, Gandhi, Saurin, Triplett, Todd A., Yendewa, George, Giddings, Olivia, Anderson, Evan J., Mehta, Aneesh K., Sevransky, Jonathan E., Khor, Bernard, Rahman, Adeeb, Stadlbauer, Daniel, Dutta, Jayeeta, Xie, Hui, Kim-Schulze, Seunghee, Gonzalez-Reiche, Ana Silvia, van de Guchte, Adriana, Farrugia, Keith, Khan, Zenab, Maecker, Holden T., Elashoff, David, Brook, Jenny, Ramires-Sanchez, Estefania, Llamas, Megan, Rivera, Adreanne, Perdomo, Claudia, Ward, Dawn C., Magyar, Clara E., Fulcher, Jennifer A., Abe-Jones, Yumiko, Asthana, Saurabh, Beagle, Alexander, Bhide, Sharvari, Carrillo, Sidney A., Chak, Suzanna, Ghale, Rajani, Gonzalez, Ana, Jauregui, Alejandra, Jones, Norman, Lea, Tasha, Lee, Deanna, Lota, Raphael, Milush, Jeff, Nguyen, Viet, Pierce, Logan, Prasad, Priya A., Rao, Arjun, Samad, Bushra, Shaw, Cole, Sigman, Austin, Sinha, Pratik, Ward, Alyssa, Willmore, Andrew, Zhan, Jenny, Rashid, Sadeed, Rodriguez, Nicklaus, Tang, Kevin, Altamirano, Luz Torres, Betancourt, Legna, Curiel, Cindy, Sutter, Nicole, Paz, Maria Tercero, Tietje-Ulrich, Gayelan, Leroux, Carolyn, Connors, Jennifer, Bernui, Mariana, Kutzler, Michel A., Edwards, Carolyn, Lee, Edward, Lin, Edward, Croen, Brett, Semenza, Nicholas C., Rogowski, Brandon, Melnyk, Nataliya, Woloszczuk, Kyra, Cusimano, Gina, Bell, Mathew R., Furukawa, Sara, McLin, Renee, Marrero, Pamela, Sheidy, Julie, Tegos, George P., Nagle, Crystal, Mege, Nathan, Ulring, Kristen, Seyfert-Margolis, Vicki, Conway, Michelle, Francisco, Dave, Molzahn, Allyson, Erickson, Heidi, Wilson, Connie Cathleen, Schunk, Ron, Sierra, Bianca, Hughes, Trina, Smolen, Kinga, Desjardins, Michael, van Haren, Simon, Mitre, Xhoi, Cauley, Jessica, Li, Xiaofang, Tong, Alexandra, Evans, Bethany, Montesano, Christina, Licona, Jose Humberto, Krauss, Jonathan, Chang, Jun Bai Park, Izaguirre, Natalie, Chaudhary, Omkar, Coppi, Andreas, Fournier, John, Mohanty, Subhasis, Muenker, M. Catherine, Nelson, Allison, Raddassi, Khadir, Rainone, Michael, Ruff, William E., Salahuddin, Syim, Schulz, Wade L., Vijayakumar, Pavithra, Wang, Haowei, Wunder Jr., Elsio, Young, H. Patrick, Zhao, Yujiao, Saksena, Miti, Altman, Deena, Kojic, Erna, Srivastava, Komal, Eaker, Lily Q., Bermúdez-González, Maria C., Beach, Katherine F., Sominsky, Levy A., Azad, Arman R., Carreño, Juan Manuel, Singh, Gagandeep, Raskin, Ariel, Tcheou, Johnstone, Bielak, Dominika, Kawabata, Hisaaki, Mulder, Lubbertus CF, Kleiner, Giulio, Lee, Alexandra S., Do, Evan Do, Fernandes, Andrea, Manohar, Monali, Hagan, Thomas, Blish, Catherine A., Din, Hena Naz, Roque, Jonasel, Yang, Samuel, Brunton, Amanda, Sullivan, Peter E., Strnad, Matthew, Lyski, Zoe L., Coulter, Felicity J., Booth, J. Leland, Sinko, Lauren A., Moldawer, Lyle L., Borresen, Brittany, Roth-Manning, Brittney, Song, Li-Zhen, Nelson, Ebony, Lewis-Smith, Megan, Smith, Jacob, Tipan, Pablo Guaman, Siles, Nadia, Bazzi, Sam, Geltman, Janelle, Hurley, Kerin, Gabriele, Gio, Sieg, Scott, Vaysman, Tatyana, Bristow, Laurel, Hussaini, Laila, Hellmeister, Kieffer, Samaha, Hady, Cheng, Andrew, Spainhour, Christine, Scherer, Erin M., Johnson, Brandi, Bechnak, Amer, Ciric, Caroline R., Hewitt, Lauren, Carter, Erin, Mcnair, Nina, Panganiban, Bernadine, Huerta, Christopher, Usher, Jacob, Ribeiro, Susan Pereira, Altman, Matthew C., Becker, Patrice M., Rouphael, Nadine, Bime, Christian, and Davis, Mark M.
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- 2022
- Full Text
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49. Metabolomic signatures associated with weight gain and psychosis spectrum diagnoses: A pilot study
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Jiwon Lee, Kenya Costa-Dookhan, Kristoffer Panganiban, Nicole MacKenzie, Quinn Casuccio Treen, Araba Chintoh, Gary Remington, Daniel J. Müller, Sanjeev Sockalingam, Philip Gerretsen, Marcos Sanches, Alla Karnovsky, Kathleen A. Stringer, Vicki L. Ellingrod, Ivy F. Tso, Stephan F. Taylor, Sri Mahavir Agarwal, Margaret K. Hahn, and Kristen M. Ward
- Subjects
metabolomics ,fatty acids ,antipsychotics ,schizophrenia ,weight gain ,psychosis ,Psychiatry ,RC435-571 - Abstract
Psychosis spectrum disorders (PSDs), as well as other severe mental illnesses where psychotic features may be present, like bipolar disorder, are associated with intrinsic metabolic abnormalities. Antipsychotics (APs), the cornerstone of treatment for PSDs, incur additional metabolic adversities including weight gain. Currently, major gaps exist in understanding psychosis illness biomarkers, as well as risk factors and mechanisms for AP-induced weight gain. Metabolomic profiles may identify biomarkers and provide insight into the mechanistic underpinnings of PSDs and antipsychotic-induced weight gain. In this 12-week prospective naturalistic study, we compared serum metabolomic profiles of 25 cases within approximately 1 week of starting an AP to 6 healthy controls at baseline to examine biomarkers of intrinsic metabolic dysfunction in PSDs. In 17 of the case participants with baseline and week 12 samples, we then examined changes in metabolomic profiles over 12 weeks of AP treatment to identify metabolites that may associate with AP-induced weight gain. In the cohort with pre-post data (n = 17), we also compared baseline metabolomes of participants who gained ≥5% baseline body weight to those who gained
- Published
- 2023
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50. Feasibility of Embedding a Randomised Clinical Trial (RCT) into an Electronic Medical Record (EMR) for Patients Admitted to an Intensive Care Unit (ICU).
- Author
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Haustine Patt Panganiban, Chinh Dam Nguyen, Yasmin Ali Abdelhamid, Melissa Ankravs, Emily Karahalios, Christopher Macisaac, Tom Rechnitzer, Lucy Sharrock, An Tran-Duy, Timothy Fazio, and Adam M. Deane
- Published
- 2023
- Full Text
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