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1. On sparsity, power-law and clustering properties of graphex processes

Author

Caron, F, Panero, F, and Rousseau, J

Subjects
Probability (math.PR), FOS: Mathematics, Mathematics - Statistics Theory, Statistics Theory (math.ST), Mathematics - Probability
Abstract

This paper investigates properties of the class of graphs based on exchangeable point processes. We provide asymptotic expressions for the number of edges, number of nodes, and degree distributions, identifying four regimes: (i) a dense regime, (ii) a sparse, almost dense regime, (iii) a sparse regime with power-law behaviour, and (iv) an almost extremely sparse regime. We show that, under mild assumptions, both the global and local clustering coefficients converge to constants which may or may not be the same. We also derive a central limit theorem for subgraph counts and for the number of nodes. Finally, we propose a class of models within this framework where one can separately control the latent structure and the global sparsity/power-law properties of the graph.

Published
2022
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2. Power-law phenomena in Bayesian nonparametrics

Author

Panero, F, Lambiotte, R, Williamson, S, Caron, F, and Rousseau, J

Subjects
Machine learning, Statistics, Spatial analysis (Statistics), Data privacy
Abstract

Bayesian methods constitute a popular approach to perform statistical inference and predict phenomena of interest. Surely, part of the popularity of the Bayesian paradigm can be linked to their intuitive core idea: to take advantage of the user's prior knowledge and integrate it in the statistical procedure. The result of this synergy is the posterior distribution, focal point of Bayesian inference and instrument to quantify the uncertainty of the estimation. This thesis collects the work done as a research student on statistical models, built with the tools of Bayesian nonparametrics, to describe power-law distributed data. The motivation of the proposed models are to be found in two different fields of application: complex networks and privacy assessment. After the introduction, in the first half of the thesis I concentrate on the proposal and analysis of models for networks, the mathematical objects that describe relations among entities by representing them as nodes connected through links. Power-laws usually appear in real-world networks as the distribution function of the degrees, namely the number of links of the nodes. The two pieces of work presented belong to the graphex process framework, a flexible generating process which allows to mimic empirically observed networks characteristics. Chapter 2 fits into this framework and extends the original proposal of Caron and Fox (2017) to provide a novel modelling approach to describe sparse networks with spatial structure or other covariates. An approximate inference strategy is provided and tested on simulated data. The paper presented in chapter 3 casts light on the asymptotic properties of networks generated under the graphex process, proving the desirable properties of sparsity, power-law degree distributions, clustering and two central limit theorems. The second half of the thesis is devoted to the development of statistical methods to quantify the risk of disclosure, which arises whenever datasets with records of individuals are published: an intruder could match the data with prior information and disclose the identity, and therefore the sensitive features, of a person. Chapter 4 develops an estimator to quantify this risk using the Pitman-Yor process, a popular prior on probability distributions that has a distinguishable power-law tail. A closed form posterior distribution of the estimator is provided in a convenient mixture representation, and experiments on both simulated and real data show the effectiveness of the method. Chapter 5 deals with the estimation of the same risk under no distributional assumptions, using a fully nonparametric method. The estimator is extremely easy to understand, fast to compute and has provable guarantees of optimality. Chapter 6 concludes the thesis with a final summary and some proposals to extend the current work towards new research directions.

Published
2022

6. Prediction of dry matter, carbon and ash contents and identification of Calycophyllum spruceanum (Benth) organs by Near-Infrared spectrophotometry

Author

CIARNOSCHI, L. D., OLIVEIRA, L. C. de, SIMEONE, M. L. F., PANERO, F. dos S., PANERO, P. dos S., RUIZ RODRIGUEZ, A., ALVES FILHO, E. G., PEREIRA, M. G., SILVA, L. M. da, LUCAS DALMOLIN CIARNOSCHI, Consultor Júnior I da STCP Engenharia de Projetos, Curitiba, Paraná, LUIS CLAUDIO DE OLIVEIRA, CPAF-AC, MARIA LUCIA FERREIRA SIMEONE, CNPMS, FRANCISCO DOS SANTOS PANERO, Professor da Universidade Federal de Roraima, PEDRO DOS SANTOS PANERO, Professor do Instituto Federal de Educação, Ciência e Tecnologia de Roraima, Boa Vista, RR, ANSELMO RUIZ RODRIGUEZ, Professor da Universidade Federal do Acre, ELENILSON G. ALVES FILHO, Professor da Universidade Federal do Ceará, MARCOS GERVASIO PEREIRA, Professor da Universidade Federal Rural do Rio de Janeiro, and LUCIELIO MANOEL DA SILVA, CPATC.

Subjects
Matéria Seca, Produção, Espectroscopia no infravermelho próximo, Acre, Analytical Chemistry, Regressão Linear, Near-infrared spectroscopy, Análisis de regresión, Carbono, Dry matter accumulation, Calycophyllum Spruceanum, Productos forestales no madereros, Acumulación de materia seca, Spectroscopy, Espectroscopía del infrarrojo cercano, Produto florestal não madeireiro (PFNM), Mulateiro, Cinza, Wood ash, Ceniza de madera, Carbon, Amazonia Occidental, Amazônia Ocidental, Western Amazon, Nontimber forest products, Regression analysis
Abstract

Calycophyllum spruceanum (Benth) is a tree of the Amazon region popularly known as 'mulateiro', whose wood has multiple uses, from energy to folk medicine. Thus, it is extremely important to evaluate desirable characteristics, through quick methods that meet the principles of green chemistry. The objective of this study was to evaluate the potential of the near-infrared (NIR) spectroscopy technique for the prediction of dry matter, carbon and ash contents and identification of parts of C. spruceanum trees. The Partial Least Squares (PLS) regression model applied within the spectral range of 400-2498 nm proved to be adequate to estimate the dry matter, carbon and ash contents in C. spruceanum sapwood and bark samples, with R2 above 0.90 in both calibration and validation. Hierarchical cluster analysis and principal component analysis techniques when applied to the spectra were able to efficiently separate bark from sapwood. The results show that the NIR technique developed can be used in the determination of dry matter, carbon and ash contents in C. spruceanum, in addition to its discriminatory power in the separation of parts of the plant. Made available in DSpace on 2022-06-22T04:00:25Z (GMT). No. of bitstreams: 1 27328.pdf: 2041971 bytes, checksum: e7951753116916d19c30a538608898d1 (MD5) Previous issue date: 2022

Published
2022
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10. Issues with Nonparametric Disclosure Risk Assessment

Author

Camerlenghi, F, Favaro, S, Naulet, Z, Panero, F, Camerlenghi, F, Favaro, S, Naulet, Z, and Panero, F

Subjects
disclosure risk assessment, microdata sample, parametric inference, nonparametric inference
Published
2019

11. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Author

Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., Agrusta M., Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., and Agrusta M.

Abstract

Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50–75 years with type 2 diabetes inadequately controlled with metformin monotherapy (2–3 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and previous cardiovascular events, to add-on pioglitazone (15–45 mg) or a sulfonylurea (5–15 mg glibenclamide, 2–6 mg glimepiride, or 30–120 mg gliclazide, in accordance with local practice). The trial was unblinded, but event adjudicators were unaware of treatment assignment. The primary outcome, assessed with a Cox proportional-hazards model, was a composite of first occurrence of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularisation, assessed in the modified intention-to-treat population (all randomly assigned participants with baseline data available and without any protocol violations in relation to inclusion or exclusion criteria). This study is registered with ClinicalTrials.gov, number NCT00700856. Findings Between Sept 18, 2008, and Jan 15, 2014, 3028 patients were randomly assigned and included in the analyses. 1535 were assigned to pioglitazone and 1493 to sulfonylureas (glibenclamide 24 [2%], glimepiride 723 [48%], gliclazide 745 [50%]). At baseline, 335 (11%) participants had a previous cardiovascular event. The study was stopped early on the basis of a futility analysis after a median follow-up of 57·3 months. The primary outcome occurred in 105 patients (1·5 per 100 person-years) who were given pioglitazone and 108 (1·5 p

Published
2017

12. Separation of Cultivars of Soybeans by Chemometric Methods Using Near Infrared Spectroscopy

Author

PANERO, J. S., SILVA, H. E. B. da, PANERO, P. S., SMIDERLE, O. J., PANERO, F. S., FARIA, F. S. E. D. V., RODRIGUEZ, A. F. R., and OSCAR JOSE SMIDERLE, CPAF-Roraima.

Subjects
Hierarchical cluster analysis, Soybean classification
Abstract

Made available in DSpace on 2018-03-13T00:35:06Z (GMT). No. of bitstreams: 1 727942750021PB.pdf: 1034238 bytes, checksum: 5285573c242e3cac13b8cf10044c4eb3 (MD5) Previous issue date: 2018-03-12

Published
2018

20. Down to air. Atmosfera e pratiche terra terra in Palestina

Author

Alliegro, EV, Armiero, M, Battaglini, L, Bonato, L, Bougleux, E, Cavaglià, G, Debili, P, Genovese, D, Gentile, C, Mascadri, G, Mondo, D, Panero, F, Tondolo, M, Turroni, M, Van Aken, M, Vianello, R, Villa, M, Zola, L, Alliegro, EV, Armiero, M, Battaglini, L, Bonato, L, Bougleux, E, Cavaglià, G, Debili, P, Genovese, D, Gentile, C, Mascadri, G, Mondo, D, Panero, F, Tondolo, M, Turroni, M, Van Aken, M, Vianello, R, Villa, M, and Zola, L

Abstract

“Terra terra” è una metafora italiana che mi ha sempre attratto per la capacità di rendere conto della condizione contadina e del lavoro agricolo: visualizza il guardare basso, le condizioni spesso dipendenti di chi lavora in agricoltura, proprio raddoppiando la presenza della terra come attore principale. Simile a down to earth in inglese, nella svalutazione del lavoro agricolo come dipendenza e ignoranza, è venuto a definire la “semplicità” del lavoro con la terra, rivalutato oggi all’interno delle questioni ambientali e dopo decenni di abbandono del lavoro agricolo, e non solo in Italia. Questa metafora porta però con sé un distanziamento, un’ “emancipazione” dalle relazioni atmosferiche e da vicoli ambientali, che invece hanno sempre costituito la base dei saperi rurali locali nell’orientare le pratiche lavorative, nei limiti e potenzialità delle risorse: un distanziamento dalle relazione dal tempo “su nell’aria” (Strauss and Orlove, 2003) che oggi è amplificato nell’immaginario comune dai cambiamenti climatici e atmosferici, dove le stagioni non propongono più regolarità e uniformità e sono alla base di un disorientamento e spaesamento, tanto dei piccoli agricoltori quanto, seppur più diniegato, della società in generale. L’ambiente cambia, tanto più a partire dalla dimensione più aleatoria, invisibile, imprevedibile dall’alto, un aspetto che lo rende oggi impensabile e perturbante. Se il rapporto con l’atmosfera è sempre stato ambivalente, oggi è centrale nel ripensare e comprendere i rapporti tra società e ambiente e pone in luce le contraddizioni dei nostri modelli “materiali” schiacciati a terra e sconnessi dal tempo atmosferico. Invertire la metafora quindi, con down to air meglio esprime la antica connessione incorporata nei saperi locali dell’intima connessione tra saperi dell’incertezza e della relazionalità con il tempo e pratiche, queste sì, tutte “terra terra” ma che si orientano guardando in alto, sentendo il vento, o la reazione degli insetti per c

Published
2017

24. Incidence of type 1 diabetes is increasing both in children and young adults in Northern Italy: 1984-2004 temporal trend

Author

Bruno, Graziella, Novelli, G, Panero, F, Perotto, M, Monasterolo, F, Bona, G, Perino, A, Rabbone, I, CAVALLO PERIN, Paolo, Cerutti, Franco, and Trovati, Mariella

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Time Factors, Adolescent, Endocrinology, Diabetes and Metabolism, Prevalence, Young Adult, Diabetes mellitus, Epidemiology, Internal Medicine, medicine, Humans, Young adult, Age of Onset, Child, Demography, Type 1 diabetes, Sex Characteristics, business.industry, Incidence (epidemiology), Incidence, Age Factors, Infant, medicine.disease, Diabetes Mellitus, Type 1, El Niño, Italy, Child, Preschool, Regression Analysis, Female, Age of onset, business
Abstract

A shift towards younger age at onset of diabetes in susceptible people has been suggested as a possible explanation for the increasing temporal trend in incidence of type 1 diabetes. We aimed to test this hypothesis by assessing trends in incidence rates in the period 1984-2004 in children and young adults in Northern Italy.The study bases were: (1) children resident in the Province of Turin in the period 1984-2004 and in the remaining areas of the Piedmont Region in the period 1990-2004; and (2) young adults (15-29 years) resident in the Province of Turin in the period 1984-2003. Temporal trends in rates were analysed using Poisson regression models.A total of 1,773 incident cases were identified. Overall incidence rates/100,000 person-years in the age groups 0-14 and 15-29 years were 11.3 (95% CI 10.7-12.0) and 7.1 (95% CI 6.6-7.7), respectively, with sex differences among young adults only (incidence rate ratio [IRR] in males vs females 1.41 [95% CI 1.20-1.64]). Average annual increases in incidence rates were similar in children and young adults at 3.3% (95% CI 2.5-4.1). Compared with the period 1984-89, in 2000-2004 a 60% higher risk was found in both age 0-14 years (IRR 1.60, 95% CI 1.31-1.95) and 15-29 years (IRR 1.57, 95% CI 1.26-1.96) groups. The Poisson modelling showed no interaction between calendar period and age at onset.Incidence of type 1 diabetes in Northern Italy is increasing over time in both children and young adults, not supporting the hypothesis of a shift towards younger age as the main explanation for the increasing temporal trend in children.

Published
2009

26. Application of the exploratory analysis of data in the geographical discrimination of okra from Rio Grande do Norte and Pernambuco

Author

Panero,F. S., Vieira,M. F. P., Cruz,Â. M. F., Moura,M. F. V., and Silva,H. E. B. da

Subjects
Quimiometria, PCA, okra, HCA, Análise exploratória de dados, exploratory analysis, chemometrics, quiabo
Abstract

Foram analisadas amostras de quiabo dos municípios de Caruaru e Vitória de Santo Antão, em Pernambuco, assim como nos municípios de Ceará-Mirim, Macaíba e Extremoz no estado do Rio Grande do Norte. A aplicação de dois métodos de análise exploratória de dados: Análise de Componentes principais - PCA e Análise de Agrupamentos Hierárquicos - HCA permitiu a discriminação geográfica do quiabo proveniente dos dois estados. Samples of okra from Caruaru and Vitória of Santo Antão, in the State of Pernambuco, and Ceará-Mirim, Macaíba and Extremoz in the State of Rio Grande do Norte have been analysed. Two different methods were applied in the data treatment allowing to geographically discriminate samples from different origins: Principal Component Analysis - PCA and Hierarquical Cluster Analysis - HCA.

Published
2009

30. 119 Modification of brain tumor microenvironment by spinal cord stimulation

Author

Clavo, B., primary, Robaina, F., additional, Valcarcel, B., additional, Montz, R., additional, Catala, L., additional, Ruiz-Egea, E., additional, Lloret, M., additional, Macias, D., additional, Lara, P.C., additional, Jorge, I.J., additional, Gonzalez, G., additional, Hernandez, M.A., additional, Panero, F., additional, and Carreras, J.L., additional

Published
2006
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31. Ultrasound to reduce cognitive errors in the ED.

Author

Elia F, Panero F, Molino P, Ferrari G, Aprà F, Elia, Fabrizio, Panero, Francesco, Molino, Paola, Ferrari, Giovanni, and Aprà, Franco

Abstract

Emergency medicine setting is intrinsically prone to a greater risk of medical errors than other specialties. Cognitive errors are particularly frequent when the clinical decision-making process heavily relies on heuristics. These could be defined as "mental shortcuts," which enable physicians to rapidly overcome both time and efforts required by the normative reasoning. Our article demonstrates how emergency physicians' thinking may be affected by failed heuristics, through the description of 3 real clinical cases. We aimed to show how the proper use of a widespread and easy-learning technology, such as goal-directed, focused ultrasonography, may both counteract cognitive errors and favor the right interpretation of other examinations. [ABSTRACT FROM AUTHOR]

Published
2012
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33. C-reactive protein and 5-year survival in type 2 diabetes: the Casale Monferrato Study.

Author

Bruno G, Fornengo P, Novelli G, Panero F, Perotto M, Segre O, Zucco C, Deambrogio P, Bargero G, Perin PC, Bruno, Graziella, Fornengo, Paolo, Novelli, Giulia, Panero, Francesco, Perotto, Massimo, Segre, Olivia, Zucco, Chiara, Deambrogio, PierCarlo, Bargero, Giuseppe, and Perin, Paolo Cavallo

Abstract

Objective: To determine to what extent plasma C-reactive protein (CRP) values influence 5-year all-cause and cardiovascular mortality in type 2 diabetic individuals, independently of albumin excretion rate (AER) and other cardiovascular risk factors, and its incremental usefulness for predicting individual risk of mortality.Research Design and Methods: Measurements of CRP were performed in 2,381 of 3,249 (73.3%) subjects as part of the population-based Casale Monferrato Study. Its association with 5-year all-cause and cardiovascular mortality was assessed with multivariate Cox proportional hazards modeling. The C statistic and measures of calibration and global fit were also assessed.Results: Results are based on 496 deaths in 11.717 person-years of observations (median follow-up 5.4 years). With respect to subjects with CRP < or =3 mg/l, those with higher values had an adjusted hazard ratio (HR) of 1.51 (95% CI 1.18-1.92) for all-cause mortality and 1.44 (0.99-2.08) for cardiovascular mortality. In normoalbuminuric subjects, respective HRs of CRP were 1.56 (1.13-2.15) and 1.65 (1.00-2.74), AER being neither a modifier nor a confounder of CRP association. In analysis limited to diabetic subjects without cardiovascular disease (CVD), adjusted HRs were 1.67 (1.24-2.24) for all-cause mortality and 1.36 (0.83-2.24) for cardiovascular mortality. The improvement in individual risk assessment was marginal when measured with various statistical measures of model discrimination, calibration, and global fit.Conclusions: CRP measurement is independently associated with short-term mortality risk in type 2 diabetic individuals, even in normoalbuminuric subjects and in those without a previous diagnosis of CVD. Its clinical usefulness in individual assessment of 5-year risk of mortality, however, is limited. [ABSTRACT FROM AUTHOR]

Published
2009
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34. Optimal disclosure risk assessment

Author

Francesca Panero, Zacharie Naulet, Federico Camerlenghi, Stefano Favaro, Camerlenghi, F, Favaro, S, Naulet, Z, and Panero, F

Subjects
Statistics and Probability, Poisson abundance model, Polynomial approximation, Population, Mathematics - Statistics Theory, Sample (statistics), 02 engineering and technology, Statistics Theory (math.ST), Sampling fraction, Nonparametric inference, Poisson distribution, 01 natural sciences, Upper and lower bounds, Disclosure risk assessment, 62G05, 62C20, 010104 statistics & probability, symbols.namesake, Statistics, 0202 electrical engineering, electronic engineering, information engineering, FOS: Mathematics, HA Statistics, 0101 mathematics, education, Categorical variable, Mathematics, Microdata sample, education.field_of_study, Estimator, 020206 networking & telecommunications, 16. Peace & justice, Minimax, Optimal minimax procedure, SECS-S/01 - STATISTICA, symbols, Statistics, Probability and Uncertainty
Abstract

Protection against disclosure is a legal and ethical obligation for agencies releasing microdata files for public use. Consider a microdata sample of size $n$ from a finite population of size $\bar{n}=n+\lambda n$, with $\lambda>0$, such that each record contains two disjoint types of information: identifying categorical information and sensitive information. Any decision about releasing data is supported by the estimation of measures of disclosure risk, which are functionals of the number of sample records with a unique combination of values of identifying variables. The most common measure is arguably the number $\tau_{1}$ of sample unique records that are population uniques. In this paper, we first study nonparametric estimation of $\tau_{1}$ under the Poisson abundance model for sample records. We introduce a class of linear estimators of $\tau_{1}$ that are simple, computationally efficient and scalable to massive datasets, and we give uniform theoretical guarantees for them. In particular, we show that they provably estimate $\tau_{1}$ all of the way up to the sampling fraction $(\lambda+1)^{-1}\propto (\log n)^{-1}$, with vanishing normalized mean-square error (NMSE) for large $n$. We then establish a lower bound for the minimax NMSE for the estimation of $\tau_{1}$, which allows us to show that: i) $(\lambda+1)^{-1}\propto (\log n)^{-1}$ is the smallest possible sampling fraction; ii) estimators' NMSE is near optimal, in the sense of matching the minimax lower bound, for large $n$. This is the main result of our paper, and it provides a precise answer to an open question about the feasibility of nonparametric estimation of $\tau_{1}$ under the Poisson abundance model and for a sampling fraction $(\lambda+1)^{-1}

Published
2021

35. Down to air. Atmosfera e pratiche terra terra in Palestina

Author

Van Aken, M, Alliegro, EV, Armiero, M, Battaglini, L, Bonato, L, Bougleux, E, Cavaglià, G, Debili, P, Genovese, D, Gentile, C, Mascadri, G, Mondo, D, Panero, F, Tondolo, M, Turroni, M, Van Aken, M, Vianello, R, Villa, M, and Zola, L

Subjects
M-DEA/01 - DISCIPLINE DEMOETNOANTROPOLOGICHE, ambiente, Territori Occupati, Antropocene, saperi locali, cambiamenti climatici
Abstract

“Terra terra” è una metafora italiana che mi ha sempre attratto per la capacità di rendere conto della condizione contadina e del lavoro agricolo: visualizza il guardare basso, le condizioni spesso dipendenti di chi lavora in agricoltura, proprio raddoppiando la presenza della terra come attore principale. Simile a down to earth in inglese, nella svalutazione del lavoro agricolo come dipendenza e ignoranza, è venuto a definire la “semplicità” del lavoro con la terra, rivalutato oggi all’interno delle questioni ambientali e dopo decenni di abbandono del lavoro agricolo, e non solo in Italia. Questa metafora porta però con sé un distanziamento, un’ “emancipazione” dalle relazioni atmosferiche e da vicoli ambientali, che invece hanno sempre costituito la base dei saperi rurali locali nell’orientare le pratiche lavorative, nei limiti e potenzialità delle risorse: un distanziamento dalle relazione dal tempo “su nell’aria” (Strauss and Orlove, 2003) che oggi è amplificato nell’immaginario comune dai cambiamenti climatici e atmosferici, dove le stagioni non propongono più regolarità e uniformità e sono alla base di un disorientamento e spaesamento, tanto dei piccoli agricoltori quanto, seppur più diniegato, della società in generale. L’ambiente cambia, tanto più a partire dalla dimensione più aleatoria, invisibile, imprevedibile dall’alto, un aspetto che lo rende oggi impensabile e perturbante. Se il rapporto con l’atmosfera è sempre stato ambivalente, oggi è centrale nel ripensare e comprendere i rapporti tra società e ambiente e pone in luce le contraddizioni dei nostri modelli “materiali” schiacciati a terra e sconnessi dal tempo atmosferico. Invertire la metafora quindi, con down to air meglio esprime la antica connessione incorporata nei saperi locali dell’intima connessione tra saperi dell’incertezza e della relazionalità con il tempo e pratiche, queste sì, tutte “terra terra” ma che si orientano guardando in alto, sentendo il vento, o la reazione degli insetti per condividere sistemi di significati sociali ed ecologici assieme. Il calendario atmosferico palestinese, sopravvissuto in racconti orali dei rifugiati ma tanto più nelle pratiche agricole di agricoltori nella West Bank, è un esempio storico di relazione culturale all’imprevedibilità e variabilità del tempo, attraverso sistemi di significato, rituali, partiche lavorative co-involte nell’ambiente atmosferico e nei suoi cambiamenti e capricci, orientati storicamente in Medio Oriente a definire i ritmi dell’aridità e della piovosità come spartiacque fondamentale.

Published
2017

36. SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.

Author

Cosentini R, Groff P, Brambilla AM, Camajori Todeschini R, Gangitano G, Ingrassia S, Marino R, Nori F, Pagnozzi F, Panero F, and Ferrari R

Subjects
Humans, Respiration, Artificial, SARS-CoV-2, COVID-19 complications, COVID-19 therapy, Emergency Medicine, Noninvasive Ventilation methods, Respiratory Insufficiency
Abstract

The rapid worldwide spread of the Coronavirus disease (COVID-19) crisis has put health systems under pressure to a level never experienced before, putting intensive care units in a position to fail to meet an exponentially growing demand. The main clinical feature of the disease is a progressive arterial hypoxemia which rapidly leads to ARDS which makes the use of intensive care and mechanical ventilation almost inevitable. The difficulty of health systems to guarantee a corresponding supply of resources in intensive care, together with the uncertain results reported in the literature with respect to patients who undergo early conventional ventilation, make the search for alternative methods of oxygenation and ventilation and potentially preventive of the need for tracheal intubation, such as non-invasive respiratory support techniques particularly valuable. In this context, the Emergency Department, located between the area outside the hospital and hospital ward and ICU, assumes the role of a crucial junction, due to the possibility of applying these techniques at a sufficiently early stage and being able to rapidly evaluate their effectiveness. This position paper describes the indications for the use of non-invasive respiratory support techniques in respiratory failure secondary to COVID-19-related pneumonia, formulated by the Non-invasive Ventilation Faculty of the Italian Society of Emergency Medicine (SIMEU) on the base of what is available in the literature and on the authors' direct experience. Rationale, literature, tips & tricks, resources, risks and expected results, and patient interaction will be discussed for each one of the escalating non-invasive respiratory techniques: standard oxygen, HFNCO, CPAP, NIPPV, and awake self-repositioning. The final chapter describes our suggested approach to the failing patient., (© 2022. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)

Published
2022
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37. SARS-CoV-2 microfluidic antigen point-of-care testing in Emergency Room patients during COVID-19 pandemic.

Author

Burdino E, Cerutti F, Panero F, Allice T, Gregori G, Milia MG, Cavalot G, Altavilla A, Aprà F, and Ghisetti V

Subjects
Antigens, Viral, Emergency Service, Hospital, Humans, Microfluidics, Pandemics, Point-of-Care Systems, Point-of-Care Testing, Sensitivity and Specificity, COVID-19, SARS-CoV-2
Abstract

In Emergency Room, Point-of-care antigen testing for SARS-CoV-2 antigen can expedite clinical strategies for patient management. We tested 1,232 consecutive patients during Italian second wave peak using the recent LumiraDx microfluidic assay. This assay showed high concordance (96.9 %), sensitivity and specificity compared to molecular testing, being highly valuable., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2022
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38. Determination of salivary cortisol to assess time-related changes of the adrenal response to stress in critically ill patients.

Author

Puglisi S, Pizzuto A, Laface B, Panero F, Aprà F, Palmas E, Perotti P, Reimondo G, Boccuzzi A, and Terzolo M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Hydrocortisone blood, Male, Middle Aged, Time Factors, Young Adult, Adrenal Cortex physiopathology, Critical Illness, Hydrocortisone analysis, Saliva chemistry, Stress, Physiological physiology
Abstract

Background: The value of salivary cortisol measurement to study stress-related adrenal response is controversial. The study aim was to assess the role of salivary cortisol measurement to detect time-related changes of adrenal response in critically ill patients., Patients and Methods: Patients with organ failure, sepsis or trauma were prospectively recruited in the Emergency Department. Serum and salivary cortisol were measured at baseline (T0) and after 48 h (T48). In 33 patients ACTH test was also done., Results: Fifty-five patients were studied and classified as septic (22) or non-septic (33). We found a significant correlation between serum and salivary cortisol at T0 and T48. No patient had baseline serum cortisol < 276 nmol/L and salivary cortisol significantly decreased at T48 in almost all patients. A delta serum cortisol < 250 nmol/L after ACTH was found in only 4 patients who showed elevated baseline cortisol levels., Conclusion: We found that reduced baseline and post-ACTH cortisol levels are uncommon in our samples. In patients able to provide adequate saliva samples, salivary cortisol may be used to check the degree of stress-induced response and appears as a suitable tool for multiple measurements over time., (Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.)

Published
2019
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39. Drama of medical dramas.

Author

Elia F, Panero F, Crupi V, and Aprà F

Subjects
Cardiopulmonary Resuscitation, Humans, Drama, Television
Abstract

Competing Interests: Competing interests: None declared.

Published
2018
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40. Lung Ultrasound-Implemented Diagnosis of Acute Decompensated Heart Failure in the ED: A SIMEU Multicenter Study.

Author

Pivetta E, Goffi A, Lupia E, Tizzani M, Porrino G, Ferreri E, Volpicelli G, Balzaretti P, Banderali A, Iacobucci A, Locatelli S, Casoli G, Stone MB, Maule MM, Baldi I, Merletti F, Cibinel GA, Baron P, Battista S, Buonafede G, Busso V, Conterno A, Del Rizzo P, Ferrera P, Pecetto PF, Moiraghi C, Morello F, Steri F, Ciccone G, Calasso C, Caserta MA, Civita M, Condo' C, D'Alessandro V, Del Colle S, Ferrero S, Griot G, Laurita E, Lazzero A, Lo Curto F, Michelazzo M, Nicosia V, Palmari N, Ricchiardi A, Rolfo A, Rostagno R, Bar F, Boero E, Frascisco M, Micossi I, Mussa A, Stefanone V, Agricola R, Cordero G, Corradi F, Runzo C, Soragna A, Sciullo D, Vercillo D, Allione A, Artana N, Corsini F, Dutto L, Lauria G, Morgillo T, Tartaglino B, Bergandi D, Cassetta I, Masera C, Garrone M, Ghiselli G, Ausiello L, Barutta L, Bernardi E, Bono A, Forno D, Lamorte A, Lison D, Lorenzati B, Maggio E, Masi I, Maggiorotto M, Novelli G, Panero F, Perotto M, Ravazzoli M, Saglio E, Soardo F, Tizzani A, Tizzani P, Tullio M, Ulla M, and Romagnoli E

Subjects
Aged, Aged, 80 and over, Clinical Protocols, Cohort Studies, Female, Humans, Italy, Lung Diseases complications, Male, Middle Aged, Predictive Value of Tests, Ultrasonography, Dyspnea diagnostic imaging, Dyspnea etiology, Emergency Service, Hospital, Heart Failure complications, Heart Failure diagnosis, Lung Diseases diagnostic imaging
Abstract

Background: Lung ultrasonography (LUS) has emerged as a noninvasive tool for the differential diagnosis of pulmonary diseases. However, its use for the diagnosis of acute decompensated heart failure (ADHF) still raises some concerns. We tested the hypothesis that an integrated approach implementing LUS with clinical assessment would have higher diagnostic accuracy than a standard workup in differentiating ADHF from noncardiogenic dyspnea in the ED., Methods: We conducted a multicenter, prospective cohort study in seven Italian EDs. For patients presenting with acute dyspnea, the emergency physician was asked to categorize the diagnosis as ADHF or noncardiogenic dyspnea after (1) the initial clinical assessment and (2) after performing LUS ("LUS-implemented" diagnosis). All patients also underwent chest radiography. After discharge, the cause of each patient's dyspnea was determined by independent review of the entire medical record. The diagnostic accuracy of the different approaches was then compared., Results: The study enrolled 1,005 patients. The LUS-implemented approach had a significantly higher accuracy (sensitivity, 97% [95% CI, 95%-98.3%]; specificity, 97.4% [95% CI, 95.7%-98.6%]) in differentiating ADHF from noncardiac causes of acute dyspnea than the initial clinical workup (sensitivity, 85.3% [95% CI, 81.8%-88.4%]; specificity, 90% [95% CI, 87.2%-92.4%]), chest radiography alone (sensitivity, 69.5% [95% CI, 65.1%-73.7%]; specificity, 82.1% [95% CI, 78.6%-85.2%]), and natriuretic peptides (sensitivity, 85% [95% CI, 80.3%-89%]; specificity, 61.7% [95% CI, 54.6%-68.3%]; n = 486). Net reclassification index of the LUS-implemented approach compared with standard workup was 19.1%., Conclusions: The implementation of LUS with the clinical evaluation may improve accuracy of ADHF diagnosis in patients presenting to the ED., Trial Registry: Clinicaltrials.gov; No.: NCT01287429; URL: www.clinicaltrials.gov.

Published
2015
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41. Diaphragm ultrasound as a new index of discontinuation from mechanical ventilation.

Author

Ferrari G, De Filippi G, Elia F, Panero F, Volpicelli G, and Aprà F

Abstract

Background: Predictive indexes of weaning from mechanical ventilation are often inaccurate. Among the many indexes used in clinical practice, the rapid shallow breathing index is one of the most accurate. We evaluated a new weaning index consisting in the diaphragm thickening fraction (DTF) assessed by ultrasound., Methods: Forty-six patients were prospectively enrolled. All patients were ventilated in pressure support through a tracheostomy tube. Patients underwent a spontaneous breathing trial (SBT) when they met all the following criteria: FiO2 < 0.5, PEEP ≤5 cmH2O, PaO2/FiO2 > 200, respiratory rate <30 breaths per minute, absence of fever, alert and cooperative, and hemodynamic stability without vaso-active therapy support. During the trial, the right hemi-diaphragm was visualized in the zone of apposition using a 10-MHz linear ultrasound probe. The patient was then instructed to perform breathing to total lung capacity (TLC) and then exhaling to residual volume (RV). Diaphragm thickness was recorded at TLC and RV, and the DTF was calculated as percentage from the following formula: Thickness at end inspiration - Thickness at end expiration / Thickness at end expiration. Also, the rapid shallow breathing index (RSBI) was calculated. Weaning failure was defined as the inability to maintain spontaneous breathing for at least 48 h, without any form of ventilatory support., Results: A significant difference between diaphragm thickness at TLC and RV was observed both in patients who succeeded SBT and patients who failed. DTF was significantly different between patients who failed and patients who succeeded SBT. A cutoff value of a DTF >36% was associated with a successful SBT with a sensitivity of 0.82, a specificity of 0.88, a positive predictive value (PPV) of 0.92, and a negative predictive value (NPV) of 0.75. By comparison, RSBI <105 had a sensitivity of 0.93, a specificity of 0.88, a PPV of 0.93, and a NPV of 0.88 for determining SBT success., Conclusions: This study shows that in our cohort of patients, the assessment of DTF by diaphragm ultrasound may perform similarly to other weaning indexes. If validated by other studies, this method may be used in clinical practice.

Published
2014
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42. Obesity is associated with lower mortality risk in elderly diabetic subjects: the Casale Monferrato study.

Author

Perotto M, Panero F, Gruden G, Fornengo P, Lorenzati B, Barutta F, Ghezzo G, Amione C, Cavallo-Perin P, and Bruno G

Subjects
Aged, Aged, 80 and over, Body Mass Index, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Cohort Studies, Diabetes Mellitus, Type 2 mortality, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies epidemiology, Diabetic Angiopathies etiology, Female, Follow-Up Studies, Humans, Italy epidemiology, Male, Obesity mortality, Obesity physiopathology, Proportional Hazards Models, Risk Factors, Cardiovascular Diseases mortality, Diabetes Mellitus, Type 2 complications, Diabetic Angiopathies mortality, Obesity complications
Abstract

The relationship between obesity and mortality in people with type 2 diabetes has not been definitely assessed. We have examined this issue in a well-characterized population-based cohort of Mediterranean diabetic people. Standardized anthropometric data from the population-based Casale Monferrato Study have been prospectively analyzed. The cohort included 1,475 people (62.6% aged ≥65 years) who had been recruited in 1991 and followed-up to December 31, 2006. Cox proportional hazards modeling was employed to estimate the independent associations between all-cause and cardiovascular mortality and BMI. Out of 1,475 people, 972 deaths occurred during a 15-year follow-up. Cox regression analyses showed that with respect to BMI <24.2 kg/m(2), values of 30.0 kg/m(2) and over were associated with lower all-cause and cardiovascular mortality risk (HR = 0.68, 95% CI 0.56-0.85, P for trend = 0.001; HR = 0.59, 0.44-0.80, P for trend = 0.002), independently of classical and new risk factors. As interaction between age and BMI was significant, we performed a stratified analysis by age, providing evidence that our finding was entirely due to a significant protective effect of BMI of 30.0 kg/m(2) and over in the elderly (all-cause mortality HR = 0.75, 95% CI 0.58-0.96; cardiovascular mortality HR = 0.67, 95% CI 0.45-0.95). In contrast, obesity was not significantly associated with mortality risk in diabetic subjects aged <65 years. Results were confirmed even excluding from the analysis individuals who died within 2 years of follow-up, smokers and those with CHD. In Mediterranean diabetic people aged ≥65 years, obesity is significantly associated with lower 15-year mortality risk. In contrast, it was not significantly associated with mortality risk in diabetic subjects aged <65 years. As more than two-thirds of people with type 2 diabetes are elderly, our findings, if confirmed, could have clinical implications.

Published
2013
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43. Perirenal fluid collection: an uncommon cause of septic shock.

Author

Lorenzati B, De Taddeo F, Nebiolo M, Perotto M, Panero F, Barale M, Spadafora L, and Cataldi W

Subjects
Abdominal Pain etiology, Abscess therapy, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Drainage, Emergency Service, Hospital, Female, Fluid Therapy, Humans, Kidney Diseases therapy, Radiography, Shock, Septic therapy, Ultrasonography, Abscess diagnostic imaging, Kidney Diseases diagnostic imaging, Shock, Septic etiology
Published
2013
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44. Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients.

Author

Panero F, Novelli G, Zucco C, Fornengo P, Perotto M, Segre O, Grassi G, Cavallo-Perin P, and Bruno G

Subjects
Adult, Age of Onset, Blood Pressure, Body Mass Index, Cardiovascular Diseases epidemiology, Cohort Studies, Diabetes Mellitus, Type 1 physiopathology, Diabetic Nephropathies epidemiology, Diabetic Neuropathies epidemiology, Fasting, Female, Humans, Hypertension epidemiology, Insulin-Secreting Cells metabolism, Italy, Male, Multivariate Analysis, Odds Ratio, Regression Analysis, C-Peptide blood, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 complications, Diabetic Angiopathies epidemiology
Abstract

Objective: A protective effect of residual beta-cell function on microvascular complications of type 1 diabetes has been suggested. Our aim was to retrospectively evaluate the association of fasting plasma C-peptide values with micro- and macrovascular complications., Research Design and Methods: We recruited a clinic-based cohort of 471 type 1 diabetic patients born after 1945 and cared for in the period 1994-2004. Centralized measurements and standardized procedures of ascertainment of micro- and macrovascular complications were employed. Individual cumulative averages of A1C up to 2007 were calculated., Results: Residual beta-cell secretion was detected even many years after diabetes diagnosis. In multivariate linear regression analysis, fasting plasma C-peptide values were positively associated with age at diagnosis (beta = 0.02; P < 0.0001) and triglycerides (beta = 0.20; P = 0.05) and inversely associated with diabetes duration (beta = -0.03; P < 0.0001) and HDL cholesterol (beta = -0.006; P = 0.03). The final model explained 21% of fasting C-peptide variability. With respect to fasting C-peptide values in the lowest tertile (<0.06 nmol/l), higher values were associated with lower prevalence of microvascular complications (odds ratio [OR] 0.59 [95% CI 0.37-0.94]) independently of age, sex, diabetes duration, individual cumulative A1C average during the study period, hypertension, and cardiovascular diseases. No association was evident with macrovascular complications (0.77 [0.38-1.58])., Conclusions: Our study shows an independent protective effect of residual beta-cell function on the development of microvascular complications in type 1 diabetes, suggesting the potential beneficial effect of treatment that allows the preservation of even modest beta-cell function over time.

Published
2009
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45. Increased locoregional blood flow in brain tumors after cervical spinal cord stimulation.

Author

Clavo B, Robaina F, Catalá L, Valcárcel B, Morera J, Caramés MA, Ruiz-Egea E, Panero F, Lloret M, and Hernández MA

Subjects
Adult, Aged, Antimetabolites, Antineoplastic therapeutic use, Antineoplastic Agents therapeutic use, Blood Flow Velocity, Brain Neoplasms diagnostic imaging, Carotid Artery, Common physiology, Combined Modality Therapy, Dose Fractionation, Radiation, Electric Stimulation instrumentation, Female, Follow-Up Studies, Humans, Hydroxyurea therapeutic use, Male, Middle Aged, Middle Cerebral Artery diagnostic imaging, Neoplasm Staging, Tegafur therapeutic use, Tomography, Emission-Computed, Single-Photon, Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Transcranial, Brain Neoplasms blood supply, Brain Neoplasms therapy, Spinal Cord physiology
Abstract

Object: Patients with high-grade gliomas have poor prognoses following standard treatment. Generally, malignant brain tumors have a decreased blood flow that results in increased resistance to radiation and reduced delivery of chemotherapeutic agents and oxygen. The aim of the present study was to assess the effect of spinal cord stimulation (SCS) on locoregional blood flow in high-grade tumors in the brain., Methods: Fifteen patients (11 with Grade III and four with Grade IV brain tumors) had SCS devices inserted prior to scheduled radiotherapy. Both before and after SCS, the patients underwent the following procedures: 1) single-photon emission computerized tomography (SPECT) scanning; 2) middle cerebral artery (MCA) blood flow velocity measurements (centimeters/second) with the aid of transcranial Doppler (TCD) ultrasonography; and 3) common carotid artery (CCA) blood flow volume quantification (milliliters/minute) based on time-domain processing by using color Doppler ultrasonography. The indices demonstrated on SPECT scanning before SCS were significantly lower (p < 0.001) in tumor sites compared with those in peritumoral sites (32%) and healthy contralateral areas (41%). Poststimulation results revealed the following: 1) a mean increase of 15% in tumor blood flow in 75% of patients (p = 0.033), as demonstrated on SPECT scanning: 2) a mean increase of greater than 18% in systolic and diastolic blood flow velocities in both tumorous and healthy MCAs in all but one patient (p < 0.002), as exhibited on TCD ultrasonography; and 3) a mean increase of greater than 60% in blood flow volume in tumorous and healthy CCAs in all patients (p < 0.013), as revealed on color Doppler ultrasonography studies., Conclusions: Preliminary data show that SCS can modify locoregional blood flow in high-grade malignant tumors in the brain, thus indicating that SCS could be used to improve blood flow, oxygenation, and drug delivery to such tumors and could be a useful adjuvant in chemoradiotherapy.

Published
2003
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