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2. Food Quality Standards: Quality Issues and Challenges of Food Chain in Burkina Faso

Author

Bakary Tarnagda, Bakoué Jean Paul Karama, Alain Gustave Yaguibou, Pane B. Ouattara-Sourabié, Stéphane S. R. Kaboré, Ginette C. Goungounga, Issaka Zoungrana, Cheikna Zongo, and Aly Savadogo

Subjects
quality standard, food safety, globalgap, brc / ifs, Agriculture, Nutrition. Foods and food supply, TX341-641
Abstract

Background: In Burkina Faso, the agricultural sector accounts for 35% of the gross domestic product (GDP) and employs 82% of the active population. The agri-food industries must apply the requirements of the management systems to improve their economic position and ensure sustainable development. The present study aimed to highlight the similarities and particularities of these repositories grouped according to the conformity procedures. Methods: Interviews were conducted with the state technical services and research and development support agencies of Burkina Faso in order to identify and make a comparative study of the available benchmarks. Results: We studied eight standards (ISO 9001, ISO 14001, ISO 45001, NBF 01-027: 2009, NBF 01-028: 2009, ISO 22000, BRC and IFS). These standards help improving competitiveness of the companies as well as developing the trade and food security. In addition to these standards, three private repositories were used for large distribution: Global Good Agriculture Practices, British Retail Consortium, and International Food Standard. These standards are responsible for the operations of agriculture and agribusiness in the face of numerous commercial, regulatory, health, economic, and societal requirements. They are mainly oriented towards the treatment of the main risks: cross-contamination, fatal accident, health damage, environmental pollution, unavailability of the production tool, loss of customer, etc. Conclusion: The conformity assessment of food products on the basis of specific benchmarks makes it possible to highlight the positive aspects of these products

Published
2020

3. Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular prevention

Author

Baldassarre, D, Iacoviello, L, Baetta, R, Roncaglioni, M, Condorelli, G, Remuzzi, G, Gensini, G, Frati, L, Ricciardi, W, Conaldi, P, Uccelli, A, Blandini, F, Bosari, S, Scambia, G, Fini, M, Di Malta, A, Amato, M, Veglia, F, Bonomi, A, Klersy, C, Colazzo, F, Pengo, M, Gorini, F, Auteri, L, Ferrante, G, Baviera, M, Ambrosio, G, Catapano, A, Gialluisi, A, Malavazos, A, Castelvecchio, S, Corsi-Romanelli, M, Cardani, R, La Rovere, M, Agnese, V, Pane, B, Prati, D, Spinardi, L, Liuzzo, G, Arbustini, E, Volterrani, M, Visconti, M, Werba, J, Genovese, S, Bilo, G, Invitti, C, Di Blasio, A, Lombardi, C, Faini, A, Rosa, D, Ojeda-Fernandez, L, Foresta, A, De Curtis, A, Di Castelnuovo, A, Scalvini, S, Pierobon, A, Gorini, A, Valenti, L, Luzi, L, Racca, A, Bandi, M, Tremoli, E, Menicanti, L, Parati, G, Pompilio, G, Colombo, G, Vavassori, C, Biondi, M, Frigerio, B, Ravani, A, Sansaro, D, Coggi, D, Romandini, A, Giroli, M, Giuliani, M, Bonmi, A, Rondinelli, M, Trudu, C, Cinieri, C, Monturano, M, Colazo, F, Inviti, C, Di Blasi, A, Torlasco, C, Gilardini, L, Soranna, D, Zambon, A, Perger, E, Zanotti, L, Badano, L, Cova, L, Gentilini, D, Grappiolo, L, Condoreli, G, Ferante, G, Papa, L, Savevski, V, Ieva, F, Romano, I, Remzzi, G, Ojeda, L, Clerici, F, Palumbo, A, Genini, G, Catpano, A, Mattioli, R, Longhi, E, Mantovani, L, Madotto, F, Bonaccio, M, Gianfagna, F, Ghulam, A, Magnacca, S, Noro, F, Costanzo, S, Esposito, S, Orlandi, S, Persichillo, M, Bracone, F, Panzera, T, Ruggiero, E, Parisi, R, Franciosa, S, Morelli, M, De Rita, F, Cerletti, C, de Gaetano, G, Donati, M, Mencanti, L, Romanelli, M, Cerri, A, Dubini, C, Trevisan, M, Renna, L, Milani, V, Boveri, S, Giubbilini, P, Ramputi, L, Baroni, I, De Angeli, G, Riciardi, W, Olmetti, F, Bussotti, M, Gaetano, C, Baiardi, P, Bachetti, T, Balbi, M, Comini, L, Lorenzoni, M, Olivares, A, Traversi, E, Garre, C, Sideri, R, Clemenza, F, Gentile, G, Caruana, G, Cuscino, N, Di Gesaro, G, Greco, A, Loddo, I, Tuzzolino, F, Ucelli, A, Palombo, D, Spinella, G, Mozzetta, G, Ameri, P, Zoppoli, G, Finotello, A, Porto, I, Pratesi, G, Bladini, F, Spnardi, L, Clerici, M, Pelusi, S, Bianco, C, Carpani, R, Periti, G, Margarita, S, Lanza, G, Severino, A, Pedicino, D, D'Amario, D, D'Aiello, A, Vinci, R, Bonanni, A, Brecciaroli, M, Filomia, S, Pastorino, R, Boccia, S, Urbani, A, Sanguinetti, M, Santoliquido, A, Proto, L, Tarquini, D, Grimaldi, M, Leonardi, S, Elia, A, Currao, A, Urtis, M, Di Toro, A, Giuliani, L, Caminiti, G, Marcolongo, F, Sposato, B, Guadagni, F, Morsella, V, Marziale, A, Protti, G, Baldassarre D., Iacoviello L., Baetta R., Roncaglioni M. C., Condorelli G., Remuzzi G., Gensini G., Frati L., Ricciardi W., Conaldi P. G., Uccelli A., Blandini F., Bosari S., Scambia G., Fini M., Di Malta A., Amato M., Veglia F., Bonomi A., Klersy C., Colazzo F., Pengo M., Gorini F., Auteri L., Ferrante G., Baviera M., Ambrosio G., Catapano A., Gialluisi A., Malavazos A. E., Castelvecchio S., Corsi-Romanelli M. M., Cardani R., La Rovere M. T., Agnese V., Pane B., Prati D., Spinardi L., Liuzzo G., Arbustini E., Volterrani M., Visconti M., Werba J. P., Genovese S., Bilo G., Invitti C., Di Blasio A., Lombardi C., Faini A., Rosa D., Ojeda-Fernandez L., Foresta A., De Curtis A., Di Castelnuovo A., Scalvini S., Pierobon A., Gorini A., Valenti L., Luzi L., Racca A., Bandi M., Tremoli E., Menicanti L., Parati G., Pompilio G., Colombo G., Vavassori C., Biondi M. L., Frigerio B., Ravani A., Sansaro D., Coggi D., Romandini A., Giroli M., Giuliani M., Bonmi A., Rondinelli M., Trudu C., Cinieri C., Monturano M., Colazo F., Inviti C., Di Blasi A., Torlasco C., Gilardini L., Soranna D., Zambon A., Perger E., Zanotti L., Badano L., Cova L., Gentilini D., Grappiolo L., Condoreli G., Ferante G., Papa L., Savevski V., Ieva F., Romano I., Remzzi G., Ojeda L., Clerici F., Palumbo A., Genini G. F., Catpano A., Mattioli R., Longhi E., Mantovani L. G., Madotto F., Bonaccio M., Gianfagna F., Ghulam A., Magnacca S., Noro F., Costanzo S., Esposito S., Orlandi S., Persichillo M., Bracone F., Panzera T., Ruggiero E., Parisi R., Franciosa S., Morelli M., De Rita F., Cerletti C., de Gaetano G., Donati M. B., Mencanti L., Romanelli M. M. C., Cerri A., Dubini C., Trevisan M. B., Renna L. V., Milani V., Boveri S., Giubbilini P., Ramputi L., Baroni I., De Angeli G., Riciardi W., Olmetti F., Bussotti M., Gaetano C., Baiardi P., Bachetti T., Balbi M., Comini L., Lorenzoni M., Olivares A., Traversi E., Garre C., Sideri R., Clemenza F., Gentile G., Caruana G., Cuscino N., Di Gesaro G., Greco A., Loddo I., Tuzzolino F., Ucelli A., Palombo D., Spinella G., Mozzetta G., Ameri P., Zoppoli G., Finotello A., Porto I., Pratesi G., Bladini F., Spnardi L., Clerici M., Pelusi S., Bianco C., Carpani R., Periti G., Margarita S., Lanza G. A., Severino A., Pedicino D., D'Amario D., D'Aiello A., Vinci R., Bonanni A., Brecciaroli M., Filomia S., Pastorino R., Boccia S., Urbani A., Sanguinetti M., Santoliquido A., Proto L., Tarquini D., Grimaldi M. C., Leonardi S., Elia A., Currao A., Urtis M., Di Toro A., Giuliani L., Caminiti G., Marcolongo F., Sposato B., Guadagni F., Morsella V., Marziale A., Protti G., Baldassarre, D, Iacoviello, L, Baetta, R, Roncaglioni, M, Condorelli, G, Remuzzi, G, Gensini, G, Frati, L, Ricciardi, W, Conaldi, P, Uccelli, A, Blandini, F, Bosari, S, Scambia, G, Fini, M, Di Malta, A, Amato, M, Veglia, F, Bonomi, A, Klersy, C, Colazzo, F, Pengo, M, Gorini, F, Auteri, L, Ferrante, G, Baviera, M, Ambrosio, G, Catapano, A, Gialluisi, A, Malavazos, A, Castelvecchio, S, Corsi-Romanelli, M, Cardani, R, La Rovere, M, Agnese, V, Pane, B, Prati, D, Spinardi, L, Liuzzo, G, Arbustini, E, Volterrani, M, Visconti, M, Werba, J, Genovese, S, Bilo, G, Invitti, C, Di Blasio, A, Lombardi, C, Faini, A, Rosa, D, Ojeda-Fernandez, L, Foresta, A, De Curtis, A, Di Castelnuovo, A, Scalvini, S, Pierobon, A, Gorini, A, Valenti, L, Luzi, L, Racca, A, Bandi, M, Tremoli, E, Menicanti, L, Parati, G, Pompilio, G, Colombo, G, Vavassori, C, Biondi, M, Frigerio, B, Ravani, A, Sansaro, D, Coggi, D, Romandini, A, Giroli, M, Giuliani, M, Bonmi, A, Rondinelli, M, Trudu, C, Cinieri, C, Monturano, M, Colazo, F, Inviti, C, Di Blasi, A, Torlasco, C, Gilardini, L, Soranna, D, Zambon, A, Perger, E, Zanotti, L, Badano, L, Cova, L, Gentilini, D, Grappiolo, L, Condoreli, G, Ferante, G, Papa, L, Savevski, V, Ieva, F, Romano, I, Remzzi, G, Ojeda, L, Clerici, F, Palumbo, A, Genini, G, Catpano, A, Mattioli, R, Longhi, E, Mantovani, L, Madotto, F, Bonaccio, M, Gianfagna, F, Ghulam, A, Magnacca, S, Noro, F, Costanzo, S, Esposito, S, Orlandi, S, Persichillo, M, Bracone, F, Panzera, T, Ruggiero, E, Parisi, R, Franciosa, S, Morelli, M, De Rita, F, Cerletti, C, de Gaetano, G, Donati, M, Mencanti, L, Romanelli, M, Cerri, A, Dubini, C, Trevisan, M, Renna, L, Milani, V, Boveri, S, Giubbilini, P, Ramputi, L, Baroni, I, De Angeli, G, Riciardi, W, Olmetti, F, Bussotti, M, Gaetano, C, Baiardi, P, Bachetti, T, Balbi, M, Comini, L, Lorenzoni, M, Olivares, A, Traversi, E, Garre, C, Sideri, R, Clemenza, F, Gentile, G, Caruana, G, Cuscino, N, Di Gesaro, G, Greco, A, Loddo, I, Tuzzolino, F, Ucelli, A, Palombo, D, Spinella, G, Mozzetta, G, Ameri, P, Zoppoli, G, Finotello, A, Porto, I, Pratesi, G, Bladini, F, Spnardi, L, Clerici, M, Pelusi, S, Bianco, C, Carpani, R, Periti, G, Margarita, S, Lanza, G, Severino, A, Pedicino, D, D'Amario, D, D'Aiello, A, Vinci, R, Bonanni, A, Brecciaroli, M, Filomia, S, Pastorino, R, Boccia, S, Urbani, A, Sanguinetti, M, Santoliquido, A, Proto, L, Tarquini, D, Grimaldi, M, Leonardi, S, Elia, A, Currao, A, Urtis, M, Di Toro, A, Giuliani, L, Caminiti, G, Marcolongo, F, Sposato, B, Guadagni, F, Morsella, V, Marziale, A, Protti, G, Baldassarre D., Iacoviello L., Baetta R., Roncaglioni M. C., Condorelli G., Remuzzi G., Gensini G., Frati L., Ricciardi W., Conaldi P. G., Uccelli A., Blandini F., Bosari S., Scambia G., Fini M., Di Malta A., Amato M., Veglia F., Bonomi A., Klersy C., Colazzo F., Pengo M., Gorini F., Auteri L., Ferrante G., Baviera M., Ambrosio G., Catapano A., Gialluisi A., Malavazos A. E., Castelvecchio S., Corsi-Romanelli M. M., Cardani R., La Rovere M. T., Agnese V., Pane B., Prati D., Spinardi L., Liuzzo G., Arbustini E., Volterrani M., Visconti M., Werba J. P., Genovese S., Bilo G., Invitti C., Di Blasio A., Lombardi C., Faini A., Rosa D., Ojeda-Fernandez L., Foresta A., De Curtis A., Di Castelnuovo A., Scalvini S., Pierobon A., Gorini A., Valenti L., Luzi L., Racca A., Bandi M., Tremoli E., Menicanti L., Parati G., Pompilio G., Colombo G., Vavassori C., Biondi M. L., Frigerio B., Ravani A., Sansaro D., Coggi D., Romandini A., Giroli M., Giuliani M., Bonmi A., Rondinelli M., Trudu C., Cinieri C., Monturano M., Colazo F., Inviti C., Di Blasi A., Torlasco C., Gilardini L., Soranna D., Zambon A., Perger E., Zanotti L., Badano L., Cova L., Gentilini D., Grappiolo L., Condoreli G., Ferante G., Papa L., Savevski V., Ieva F., Romano I., Remzzi G., Ojeda L., Clerici F., Palumbo A., Genini G. F., Catpano A., Mattioli R., Longhi E., Mantovani L. G., Madotto F., Bonaccio M., Gianfagna F., Ghulam A., Magnacca S., Noro F., Costanzo S., Esposito S., Orlandi S., Persichillo M., Bracone F., Panzera T., Ruggiero E., Parisi R., Franciosa S., Morelli M., De Rita F., Cerletti C., de Gaetano G., Donati M. B., Mencanti L., Romanelli M. M. C., Cerri A., Dubini C., Trevisan M. B., Renna L. V., Milani V., Boveri S., Giubbilini P., Ramputi L., Baroni I., De Angeli G., Riciardi W., Olmetti F., Bussotti M., Gaetano C., Baiardi P., Bachetti T., Balbi M., Comini L., Lorenzoni M., Olivares A., Traversi E., Garre C., Sideri R., Clemenza F., Gentile G., Caruana G., Cuscino N., Di Gesaro G., Greco A., Loddo I., Tuzzolino F., Ucelli A., Palombo D., Spinella G., Mozzetta G., Ameri P., Zoppoli G., Finotello A., Porto I., Pratesi G., Bladini F., Spnardi L., Clerici M., Pelusi S., Bianco C., Carpani R., Periti G., Margarita S., Lanza G. A., Severino A., Pedicino D., D'Amario D., D'Aiello A., Vinci R., Bonanni A., Brecciaroli M., Filomia S., Pastorino R., Boccia S., Urbani A., Sanguinetti M., Santoliquido A., Proto L., Tarquini D., Grimaldi M. C., Leonardi S., Elia A., Currao A., Urtis M., Di Toro A., Giuliani L., Caminiti G., Marcolongo F., Sposato B., Guadagni F., Morsella V., Marziale A., and Protti G.

Abstract

Introduction Prevention of cardiovascular disease (CVD) is of key importance in reducing morbidity, disability and mortality worldwide. Observational studies suggest that digital health interventions can be an effective strategy to reduce cardiovascular (CV) risk. However, evidence from large randomised clinical trials is lacking. Methods and analysis The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial designed to compare the effectiveness of an educational and motivational mobile health (mHealth) intervention versus usual care in reducing CV risk. The intervention aims at improving diet, physical activity, sleep quality, psycho-behavioural aspects, as well as promoting smoking cessation and adherence to pharmacological treatment for CV risk factors. The trial aims to enrol approximately 80 000 subjects without overt CVDs referring to general practitioners' offices, community pharmacies or clinics of Scientific Institute for Research, Hospitalization and Health Care (Italian acronym IRCCS) affiliated with the Italian Cardiology Network. All participants are evaluated at baseline and after 12 months to assess the effectiveness of the intervention on short-term endpoints, namely improvement in CV risk score and reduction of major CV risk factors. Beyond the funded life of the study, a long-term (7 years) follow-up is also planned to assess the effectiveness of the intervention on the incidence of major adverse CV events. A series of ancillary studies designed to evaluate the effect of the mHealth intervention on additional risk biomarkers are also performed. Ethics and dissemination This study received ethics approval from the ethics committee of the coordinating centre (Monzino Cardiology Center; R1256/20-CCM 1319) and from all other relevant IRBs and ethics committees. Findings are disseminated through scientific meetings and peer-reviewed journals and via social media. Partners are informed about the study's

Published
2023

5. Ficolin-2 serum levels predict the occurrence of acute coronary syndrome in patients with severe carotid artery stenosis

Author

Carbone, F, Valente, A, Perego, C, Bertolotto, M, Pane, B, Spinella, G, Palombo, D, De Simoni, M, Montecucco, F, Fumagalli, S, Carbone F., Valente A., Perego C., Bertolotto M., Pane B., Spinella G., Palombo D., De Simoni M. -G., Montecucco F., Fumagalli S., Carbone, F, Valente, A, Perego, C, Bertolotto, M, Pane, B, Spinella, G, Palombo, D, De Simoni, M, Montecucco, F, Fumagalli, S, Carbone F., Valente A., Perego C., Bertolotto M., Pane B., Spinella G., Palombo D., De Simoni M. -G., Montecucco F., and Fumagalli S.

Abstract

Background and purpose: erosion of vulnerable atherosclerotic plaques may cause life-threatening thromboembolic complications. There is indeed an urgent need to recognize a clear-cut biomarker able to identify vulnerable plaques. Here, we focused on circulating proteins belonging to the lectin pathway (LP) of complement activation. Methods: we analyzed mannose-binding lectin (MBL), ficolin-1, -2 and -3 (LP initiators) levels by ELISA in sera from n = 240 of an already published cohort of patients undergoing endarterectomy for severe carotid stenosis and followed-up until 18 months after surgery. Immunofluorescence followed by confocal and polarized light microscopy was used to detect LP initiator intraplaque localization. Spearman's rank test was drawn to investigate correlation between serum LP levels and circulating inflammatory proteins or intraplaque components. Survival analyses were then performed to test the predictive role of LP on long-term adverse outcome. Results: ficolins, but not MBL, correlated positively with 1) high circulating levels of inflammatory markers, including MPO, MMP-8, MMP-9, ICAM-1, osteopontin, neutrophil elastase, and; 2) immune cell intraplaque recruitment. Immunofluorescence showed ficolins in calcified plaques and ficolin-2 in cholesterol-enriched plaque regions in association with macrophages. In the multivariate survival analysis, ficolin-2 serum levels predicted a major adverse cardiovascular event during the follow-up, independently of symptomatic status and inflammatory markers (hazard ratio 38.6 [95 % CI 3.9–385.2]). Conclusions: ficolins support intraplaque immune cell recruitment and inflammatory processes ultimately leading to plaque vulnerability. Especially for ficolin-2 a strong predictive value toward adverse cardiovascular events was demonstrated. This evidence offers potentially new pharmacological target to dampen the inflammatory mechanisms leading to plaque vulnerability.

Published
2021

6. Aflatoxigenic potential of Aspergillus section Flavi isolated from maize seeds, in Burkina Faso

Author

Hamidou Compaore, Serge Samandoulougou, Hissein Ratongue, Fidèle Wend-bénédo Tapsoba, Alima Bambara, Donatien Kabore, Ignace Sawadogo, Hagr etou Sawadogo-Lingani, and Pane B. Ouattara-Sourabie

Subjects
Aflatoxin, Aspergillus, food.ingredient, Frequency of occurrence, biology, Aspergillus flavus, Plant Science, biology.organism_classification, Microbiology, High-performance liquid chromatography, Agar plate, Infectious Diseases, food, Agar, Food science, Incubation
Abstract

The frequency of occurrence and four principal kinds of aflatoxin concentration in maize seeds grown in Burkina Faso was investigated. Ten (10) samples collected, were analyzed by high performance liquid chromatography (HPLC) with post-column derivatisation after immunoaffinity column cleanup. Eight strains of Aspergillus section Flavi were previously isolated from these samples and cultivated on “Aspergillus flavus and parasiticus agar (AFPA)” to ascertain if they belong to A. flavus or A. parasiticus species. The qualitative ability of aflatoxin production was also previously performed by fluorescence emission under ultra violet light at 365 nm after four (4) days of incubation at 30 °C on Coconut Agar Medium (CAM). Results showed that 70% of samples were contaminated by aflatoxins. The levels ranged from 0.93 to 58.94 µg/kg. Samples M1 and M10 had high concentrations, 58.94 µg/kg and 70.73 µg/kg; whereas M4 and M5 had low concentrations from 1.68 to 0.93 µg/kg, respectively. In these samples, four were contaminated with aflatoxin B1 (AFB1) and aflatoxin G1 (AFG1), two with AFB1 and aflatoxin B2 (AFB2) and one (01) with AFB1 only. We notice that AFB1 was the most prevalent member of aflatoxins, and AFG2 was absent in all samples. Key words: Maize, Aspergillus, aflatoxins, HPLC, Burkina Faso.

Published
2021
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7. Evaluation of Clinical Outcomes After Revascularization in Patients With Chronic Limb-Threatening Ischemia: Results From a Prospective National Cohort Study (RIVALUTANDO)

Author

de Donato, G., Benedetto, F., Stilo, F., Chiesa, R., Palombo, D., Pasqui, E., Panzano, C., Pulli, R., Novali, C., Silingardi, R., Grego, F., Palasciano, G., Setacci, C., Angiletta, G., Delia, S., Rivellini, C., Palombo, B., Pane, B., Spinella, G., Pipito, N., Spinelli, D., Derone, G., Tshomba, Y., Cilli, G., Lauricella, A., Maresca, L., Antonello, M., Piazza, M., Bonvini, S., Wassermann, V., Trani, A., Barresi, A., Licitra, G., Spinelli, F., Montelione, N., Paroni, G., Magistro, G., Ceriello, D., Merlo, M., Giordano, F., Ruzzi, U., Mazzitelli, G., Mele, M., Giannace, G., Alba, G., Grottola, G., Pazzaglia, M., Giubbolini, G., Baldi, B., Guerrieri, W., Benevento, D., Cappelli, A., Kahlberg, A., Carta, N., de Donato, G., Benedetto, F., Stilo, F., Chiesa, R., Palombo, D., Pasqui, E., Panzano, C., Pulli, R., Novali, C., Silingardi, R., Grego, F., Palasciano, G., Setacci, C., Angiletta, G., Delia, S., Rivellini, C., Palombo, B., Pane, B., Spinella, G., Pipito, N., Spinelli, D., Derone, G., Tshomba, Y., Cilli, G., Lauricella, A., Maresca, L., Antonello, M., Piazza, M., Bonvini, S., Wassermann, V., Trani, A., Barresi, A., Licitra, G., Spinelli, F., Montelione, N., Paroni, G., Magistro, G., Ceriello, D., Merlo, M., Giordano, F., Ruzzi, U., Mazzitelli, G., Mele, M., Giannace, G., Alba, G., Grottola, G., Pazzaglia, M., Giubbolini, G., Baldi, B., Guerrieri, W., Benevento, D., Cappelli, A., Kahlberg, A., and Carta, N.

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Revascularization, Risk Assessment, Amputation, Surgical, chronic limb-threatening ischemia, limb salvage, medical treatment, peripheral arterial disease, revascularization, Aged, Amputation, Cardiovascular Agents, Chronic Disease, Female, Humans, Ischemia, Italy, Limb Salvage, Peripheral Arterial Disease, Prospective Studies, Recurrence, Registries, Risk Factors, Treatment Outcome, Endovascular Procedures, Vascular Surgical Procedures, Internal medicine, medicine, Prospective cohort study, business.industry, Hazard ratio, Cilostazol, Cardiovascular agent, Cardiology and Cardiovascular Medicine, business, Iloprost, medicine.drug, Cohort study
Abstract

We evaluated the outcomes of revascularization in patients with chronic limb-threatening ischemia (CLTI) treated in real-world settings. This is a prospective multicenter cohort study with 12-month follow-up enrolling patients (n = 287) with CLTI undergoing open, endovascular, or hybrid lower extremity revascularization. The primary end point was amputation-free survival (AFS) at 12 months. Cox proportional analysis was used to determine independent predictors of amputation and restenosis. At 30 days, major adverse cardiovascular and major adverse limb events (MALE) rates were 3.1% and 2.1%, respectively. At 1 year, the overall survival rate was 88.8%, the AFS was 86.6%, and the primary patency was 70.5%. Freedom from MALE was 62.5%. After multivariate analysis, smoking (hazard ratio [HR] = 2.2, P = 0.04), renal failure (HR = 2.3, P = 0.03), Rutherford class (≥5) (HR = 3.2, P = 0.01), and below-the-knee disease (HR = 2.0, P = 0.05) were significant predictors of amputation; iloprost infusion (>10 vials) (HR = 0.64, P = 0.05) was a significant protective factor. Cilostazol administration (HR = 0.77, P = 0.05) was a significant protective factor for restenosis. Results from this prospective multicenter registry offer a consistent overview of clinical outcomes of CLTI patients at 1 year when adequately revascularized. Medical treatment, including statins, cilostazol and iloprost, were associated with improved 1-year freedom from restenosis and amputation.

Published
2021

9. Food Quality Standards: Quality Issues and Challenges of Food Chain in Burkina Faso

Author

Stéphane S. R. Kaboré, Aly Savadogo, Cheikna Zongo, Ginette C. Goungounga, Alain Gustave Yaguibou, Bakoué Jean Paul Karama, Bakary Tarnagda, Pane B. Ouattara-Sourabié, and Issaka Zoungrana

Subjects
Nutrition and Dietetics, media_common.quotation_subject, lcsh:S, Public Health, Environmental and Occupational Health, Medicine (miscellaneous), lcsh:TX341-641, Agricultural economics, lcsh:Agriculture, food safety, Food chain, quality standard, globalgap, brc / ifs, Quality (business), Business, Food quality, lcsh:Nutrition. Foods and food supply, Food Science, media_common
Abstract

Background: In Burkina Faso, the agricultural sector accounts for 35% of the gross domestic product (GDP) and employs 82% of the active population. The agri-food industries must apply the requirements of the management systems to improve their economic position and ensure sustainable development. The present study aimed to highlight the similarities and particularities of these repositories grouped according to the conformity procedures. Methods: Interviews were conducted with the state technical services and research and development support agencies of Burkina Faso in order to identify and make a comparative study of the available benchmarks. Results: We studied eight standards (ISO 9001, ISO 14001, ISO 45001, NBF 01-027: 2009, NBF 01-028: 2009, ISO 22000, BRC and IFS). These standards help improving competitiveness of the companies as well as developing the trade and food security. In addition to these standards, three private repositories were used for large distribution: Global Good Agriculture Practices, British Retail Consortium, and International Food Standard. These standards are responsible for the operations of agriculture and agribusiness in the face of numerous commercial, regulatory, health, economic, and societal requirements. They are mainly oriented towards the treatment of the main risks: cross-contamination, fatal accident, health damage, environmental pollution, unavailability of the production tool, loss of customer, etc. Conclusion: The conformity assessment of food products on the basis of specific benchmarks makes it possible to highlight the positive aspects of these products.

Published
2020
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18. Cardiovascular disease (CVD) markers in patients(pts) with prostate cancer(PCa) treated with GN-RH agonists(AG) or antagonist(AN): a prospective cohort study

Author

Cavo, A., primary, Rubagotti, A., additional, Bellodi, A., additional, Zanardi, E., additional, Zinoli, L., additional, Spallarossa, P., additional, Bagnato, P., additional, Pane, B., additional, Favorini, S., additional, Barra, S., additional, Arboscello, C., additional, Arboscello, E., additional, Palombo, D., additional, and Boccardo, F., additional

Published
2017
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19. 3Mensio

Author

Pane, B, Spinella, G, Perfumo, Mc, and Palombo, D

Published
2015

21. Systemic vascular inflammation in abdominal aortic aneurysm patients: a contrast-enhanced PET/CT study

Author

Morbelli, S., Ghigliotti, G., Spinella, G., Marini, C., Irene Bossert, Cimmino, M. A., Pane, B., Rousas, N., Cittadini, G., Massollo, M., Camellino, D., Riondato, M., Palombo, D., Barisione, C., and Sambuceti, G.

Subjects
Male, Systemic Vasculitis, Contrast Media, Reproducibility of Results, Middle Aged, Multimodal Imaging, Sensitivity and Specificity, Aged, Aortic Aneurysm, Abdominal, Biological Markers, Female, Fluorodeoxyglucose F18, Humans, Positron-Emission Tomography, Radiopharmaceuticals, Tomography, X-Ray Computed, Aortic Aneurysm, X-Ray Computed, Abdominal, Tomography, Biomarkers
Abstract

The aim of this paper was to investigate the presence of systemic vascular inflammation and its relationship with risk factors and biomarkers of systemic inflammation related to atherosclerosis in asymptomatic abdominal aortic aneurysm (AAA) patients.Thirty AAA patients and 30 age-matched controls underwent contrast-enhanced 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT. C-reactive protein, erythrocyte sedimentation rate, white blood cell count and differential, serum fibrinogen, D-dimer and full lipid panel were also evaluated. Region of interest analyses were performed to obtain target-to-background (TBR) metabolism of aorta, subclavian, carotid, iliac arteries and AAA. CT-based arterial calcium load (CL) was evaluated. Arterial Metabolism and CL intergroup differences were tested (unpaired t-test). Linear regression analysis was performed only between blood biomarkers on one side and both TBR and ACL of the arterial districts that resulted significantly different between patients and controls on the other. In all the analyses P values0.05 were considered significant.FDG-uptake was higher with respect to controls in aorta, carotid and iliac arteries (P0.01, P0.007, P0.04 respectively). AAA and aorta metabolism showed an inverse correlation with HDL-chol (P0.02 and P0.01, respectively) while only aorta showed a direct correlation with lymphocytes' count (P0.02). Carotid metabolism was directly correlated with monocytes' count and C-reactive protein concentration (P0.02 and P0.004, respectively).The present findings support the relevance of systemic vascular inflammation in all phases of atherosclerosis-related disorders. Moreover they confirm the concept that acute ischemic syndromes might represent the local result of a systemic inflammation rather than the focal involvement of a single arterial lesion.

Published
2014

22. Aflatoxigenic potential of Aspergillus spp. isolated from groundnut seeds, in Burkina Faso, West Africa

Author

Aly Savadogo, Pane B. Ouattara, Nicolas Barro, Alfred S. Traore, and Philippe A. Nikiema

Subjects
Aspergillus, Aflatoxin, food.ingredient, biology, food and beverages, Aspergillus flavus, Plant Science, biology.organism_classification, Microbiology, High-performance liquid chromatography, Aspergillus parasiticus, West africa, Infectious Diseases, food, Agar, heterocyclic compounds, Food science, Incubation
Abstract

Seven strains of Aspergillus spp. have been screened for their ability to produce aflatoxins in coconut broth media. Three were local isolates and four were reference strains obtained from the United States Department of Agriculture (USDA) and Centre for Disease Control and Prevention (CDC) Atlanta and used as positive and negative controls. All strains were previously cultivated in Aspergillus flavus and Aspergillus parasiticus agar to ascertain if they belong to A. flavus or A. parasiticus species. The qualitative ability of aflatoxin production was also previously performed by fluorescence emission under ultra violet light at 312 nm after 3 days of incubation at 30°C on coconut agar. Quantitative assessment of aflatoxin production was done by high performance liquid chromatography (HPLC) with post-column derivatisation after immunoaffinity column cleanup. The reference strains (NRRL5862, CDCB5333 and CDCB4571) and one of the local isolates (BfaS1) were aflatoxin producing species in coconut broth as assessed by HPLC. Per isolate aflatoxin B1 concentration after determination by HPLC was higher than the other types of aflatoxins identified. The strains NRRL5862 and CDCB5333 have, respectively produced the following quantities of aflatoxin B1: 73.67 and 165.73 ng/ml whereas aflatoxin B2 concentrations were, respectively 0.595 and 1.736 ng/ml.

Published
2012
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23. Treatment of penetrating aortic ulcer by endoprosthesis: a single center experience

Author

Palombo, D., Lucertini, G., Robaldo, A., Pane, B., and Giovanni Spinella

Subjects
Adult, Male, Time Factors, Endovascular Procedures, Penetrating Aortic Ulcers, Endovascular treatment, Aortic Diseases, Aorta, Thoracic, Kaplan-Meier Estimate, Middle Aged, Prosthesis Design, Aortography, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation, Treatment Outcome, Italy, Humans, Female, Stents, Aorta, Abdominal, Tomography, X-Ray Computed, Ulcer, Aged, Retrospective Studies
Abstract

AIM: This is a retrospective study of a single center experience in the endovascular treatment of penetrating aortic ulcer (PAU). METHODS:Sixteen consecutive patients aged 69.1±9.6 years presenting PAU (in the aortic arch in 2, the descending thoracic aorta in 11, and in the abdominal aorta in 3) undergone therapy. Nine patients presented symptomatic, while 7 were asymptomatic. All patients underwent computer tomography angiography (CTA) of the thoracic and the abdominal aorta. Endovascular therapy alone was carried out in 12 patients, while 4 received hybrid therapy. RESULTS:One patient died of multiorgan failure after hybrid procedure. Complications consisted of type II endoleak from lumbar arteries in 1 case of endovascular procedure, and acute respiratory insufficiency in 1 patient treated by endovascular technique on the emergency basis for aortic rupture. CONCLUSION:PAU involves more frequently the descending thoracic aorta. Endovascular treatment (alone or in hybrid therapy) can give good results in patients with severe concomitant diseases. Prognosis of these patients is not favourable in most cases (48-month survival rate 47.9%) due to severe concomitant diseases.

Published
2012

24. The cannabinoid receptor type 2 is down-regulated in downstream portions of human carotid plaques

Author

Fabrizio Montecucco, Di Marzo, V., Da Silva, R. F., Vuilleumier, N., Capettini, L., Lenglet, S., Pagano, S., Piscitelli, F., Quintao, S., Bertolotto, M., Pelli, G., Galan, K., Pilet, L., Kuzmanovic, K., Burger, F., Pane, B., Spinella, G., Braunersreuther, V., Gayet-Ageron, A., Pende, A., Viviani, G. L., Palombo, D., Dallegri, F., Roux-Lombard, P., Santos, R. A. S., Stergiopulos, N., Steffens, S., and Mach, F.

Published
2012

25. Direct relationship between cell density and FDG uptake in asymptomatic aortic aneurysm close to surgical threshold: an in vivo and in vitro study

Author

Marini C, Morbelli S, Armonino R, Spinella G, Riondato M, Massollo M, Sarocchi F, Pane B, Augeri C, Abete L, Ghigliotti G, Palmieri D, Fiz F, Cittadini G, Fulcheri E, Palombo D, and Sambuceti G.

Abstract

PURPOSE: Conflicting results have been reported about the clinical value of fluorodeoxyglucose (FDG) imaging in predicting the risk of rupture of abdominal aortic aneurysm (AAA). The present study tests the hypothesis that FDG uptake is low in asymptomatic noninflammatory AAA due to the low cell density in aneurysmal walls. METHODS: Positron emission tomography (PET)/CT imaging was performed in 12 consecutive candidates for AAA surgical repair and in 12 age- and sex-matched controls. At intervention, aneurysmal walls were cut into three sequential blocks. Block A was frozen to cut three 5-¼m slices for incubation with 2-3 MBq of FDG for 5 min. Block C was first incubated with the same tracer solution for the same time and subsequently frozen to cut three 5-¼m slices. Autoradiographic images were coregistered with immunohistochemical pictures of cell density, type and DNA synthesis as assessed on block B. RESULTS: No visible uptake in abdominal aorta occurred in any patient or control subject. Immunohistochemistry documented a severe loss of wall structure, with low numbers of cells. Tracer retention directly correlated with overall cell density and with prevalence of cells synthesizing DNA. The metabolic nature of FDG uptake was confirmed by the selective effect of preliminary freezing that decreased tracer content by 90% in regions with high cell density and only by 34% in cold acellular areas. CONCLUSION: The loss of tissue structure and the marked decrease in cell density account for the low prevalence of positive findings at FDG PET imaging, at least in asymptomatic patients bearing AAAs whose diameter is close to surgical indication.

Published
2012

27. District-based abdominal aortic aneurysm screening in population aged 65 years and older

Author

Palombo, D., Lucertini, G., Pane, B., Mazzei, R., Giovanni Spinella, and Brasesco, P. C.

Subjects
abdominal aortuic aneurysm, screening program, ecocolordoppler, Aged, 80 and over, Male, Chi-Square Distribution, Time Factors, Iliac Artery, Risk Assessment, Pedigree, Early Diagnosis, Italy, Cardiovascular Diseases, Predictive Value of Tests, Residence Characteristics, Risk Factors, Prevalence, Humans, Mass Screening, Female, Aged, Aortic Aneurysm, Abdominal, Ultrasonography
Abstract

Screening for abdominal aortic aneurysms (AAAs) has been carried out in an area of Genoa (Italy) for subjects aged 65 years or more to evaluate prevalence of this disease.Between March 2007 and September 2009 8234 subjects were screened. Ultrasound examination of the abdominal aorta and the iliac arterial segments was carried out on each subject and all data related to risk factors were collected.Five hundreds-twelve (6.2%) subjects were found to have an AAA: 469 (10.8%) males and 43 (1.1%) females (significant difference, P0.01). Based on the aortic diameter, 403 (4.9%), 80 (1.0%) and 29 (0.3%) had an AAA of 3.0-3.9 cm, 4.0-4.9 cm and ≥ 5.0 cm diameter, respectively. With regards to risk factors, family history of cardiovascular disease only resulted more frequent in subjects with AAA than in those without AAA.The prevalence of patients with AAA (6.2%) was similar to previously published estimates. Nevertheless, AAA resulted very high in males. This observation is likely due to screening in a city with a very high percentage of elderly subjects. Family predisposition to cardiovascular disease resulted significant risk factor for AAA. Results of our epidemiological study provide evidence of the usefulness of AAA screening thanks to early diagnosis and appropriate treatment of AAA.

Published
2010

30. Endovascular treatment for ruptured abdominal aortic aneurysm. Review of literature

Author

Palombo, D., Lucertini, G., Pane, B., and Giovanni Spinella

Subjects
ruptured abdominal aortic aneurysm, Blood Vessel Prosthesis Implantation, Evidence-Based Medicine, Time Factors, Treatment Outcome, Endovascular trearment, Aortic Rupture, Patient Selection, Humans, Risk Assessment, Aortic Aneurysm, Abdominal
Abstract

Endovascular repair (EVAR) has produced increasing interest in the treatment of ruptured abdominal aortic aneurysms (rAAAs). Experiences to support EVAR as first approach for patients with rAAA is drawn from three sources: results of single-centre series, systematic reviews, and population-based studies. In order to validate EVAR, this technique was compared to open repair (OR), considered as the conventional treatment. These studies are heterogeneous, and often failed to demonstrate any significant difference between EVAR and OR. More recently, some population-based studies from the USA suggested advantages of EVAR over OR with regard to 30-day mortality and morbidity. Some bias have influenced the reportedCriteria for choice of EVAR varied across the studies according to the policy of the authors. Therefore, any meta-analysis should be interpreted with caution. Patients' conditions have directed the authors towards a technique instead of the other, i.e. pathophysiological factors of the patients, and anatomical conditions of the AAAs. Availability of the required endovascular equipment and trained staff allows EVAR and not always were present. Currently, according to the literature the role of EVAR in the management of rAAAs must to be further checked. Randomized trials could provide the evidence to define adequate indication to EVAR. EVAR could play an important role in the treatment of rAAAs, providing adequate selection of cases suitable for this technique.

Published
2009

31. Use of health-related quality-of-life measurements to estimate individuals' health on screening

Author

Scalone, L, Cortesi, P, Spinella, G, Pane, B, Cesana, G, Mantovani, L, Palombo, D, Cortesi, PA, Mantovani LG, Scalone, L, Cortesi, P, Spinella, G, Pane, B, Cesana, G, Mantovani, L, Palombo, D, Cortesi, PA, and Mantovani LG

Abstract

Objectives: to investigate the utility of assessing Health-Related Quality of Life (HRQoL) in a large group of subjects participating in a screening program for aneurysm and the relationship between HRQoL, diagnosis of aneurysm and related risk factors. Methods: subjects involved in this screening program were submitted the EQ-5D questionnaire to report their own HRQoL. HRQoL was reported also a second time by the subjects who were diagnosed with aneurysm during screening and who returned for a monitoring follow up visit a few months later. We evaluated compliance with HRQoL data collection and performed multiple regression analyses in order to investigate the possible relationship between demographic and clinical data with HRQoL. Results: 1,633 subjects screened (6.1% diagnosed with aneurysm) and 125 subjects diagnosed with aneurysm and attending a follow-up visit reported their HRQoL. Completion of the EQ-5D questionnaire was well accepted by both physicians-and-subjects-undergoing-screening.-HRQoL- was-not-significantly-different-between-the-screening-and-followup visits, on adjusting for age and sex. At the screening visit, HRQoL was associated with ASA class, heart condition, BMI-and-respiratory-diseases.-No-associations-were- found-at-the-follow-up-visit. Conclusion: Assessing HRQoL in screening programs is feasible and well accepted and add useful information on health of large numbers of subjects from general population. This could be considered as a routine approach to optimizing the informative role of screening programs in guiding other investigations or interventions.

Published
2013

33. 402 ADVANCED ABDOMINAL AORTIC ANEURYSMS DISPLAY A SPECIFIC INFLAMMATORY-PROATHEROSCLEROTIC PROFILE WITH RENAL DYSFUNCTION RAISED D-DIMER EXPANDED CD14++CD16+-MONOCYTES HAVING HIGH CD143

Author

Barisione, C., primary, Ghigliotti, G., additional, Palombo, D., additional, Palmieri, D., additional, Spinella, G., additional, Pane, B., additional, Fabbi, P., additional, Altieri, P., additional, Spallarossa, P., additional, Brunelli, C., additional, and Garibaldi, S., additional

Published
2011
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36. Stent-graft and multilayer stent for treatment of type II thoracoabdominal aortic aneurysm in a high-risk patient

Author

Pane, B., Giovanni Spinella, Salcuni, M., and Palombo, D.

Subjects
Male, Time Factors, Aortic Aneurysm, Thoracic, Endovascular Procedures, Contrast Media, Prosthesis Design, Aortography, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation, Treatment Outcome, Predictive Value of Tests, Risk Factors, Thoracoabdominal aortic aneurysm, Stent-graft, Multilayer stent, Outcome, Humans, Stents, Stent-graft, Tomography, X-Ray Computed, Multilayer stent, Thoracoabdominal aortic aneurysm, Outcome, Aged
Abstract

The aim of the present article was to present an alternative endovascular treatment for type II thoracoabdominal aortic aneurysm that would have the advantage of limiting the duration of the procedure and the use of contrast. A high-risk patient was admitted to our Vascular Unit for type II thoracoabdominal aneurysm according to Crawford's classification. Two thoracic stent-grafts (Valiant Captivia, Medtronic, Pewaukee, WI, USA), a bifurcated stent-graft (Endurant Medtronic) and two multilayer stents (Cardiatis SA, Isnes, Belgium) were deployed. No postoperative major complications were observed. Operative time and use of contrast material were 45 min and 80 mL, respectively. Computed angiography tomography at 1 and 6 months showed patency of visceral and renal arteries and progressive thrombosis of the aneurysmal sac. This stent-graft treatment in combination with multilayer stent could be an alternative treatment for thoracoabdominal aneurysm in high-risk patients.

38. Carotid endarterectomy: Results of the Italian Vascular Registry

Author

Palombo, D., Lucertini, G., Mambrini, S., Giovanni Spinella, and Pane, B.

Subjects
Adult, Aged, 80 and over, Male, Endarterectomy, Carotid, Time Factors, Italian vascular registry, Middle Aged, CAROTID SURGERY, Stroke, Treatment Outcome, Italy, Humans, Carotid Stenosis, Female, Registries, Aged
Abstract

The aim of this study was to evaluate the results of carotid endarterectomy (CEA) carried out in centers dedicated to vascular surgery.The study was supported by the Italian Registry for Vascular Activity, which collected the data of 89 centers of vascular surgery (almost all of the existing centers in Italy) during 2007. Data were collected for 5962 CEAs. A total of 5,809 patients (153 were operated bilaterally in two staged procedures), 3990 (68.7%) males and 1,819 (31.3%) females, whose ages ranged from 33 to 100 years (mean 72.7+/-7.78) underwent the surgery procedure. Several surgical techniques were used: i.e., standard CEA with direct suture (1477 cases, 24.8%), standard CEA with patch (2242 cases, 37.6%), and eversion technique (2243 cases, 37.6%).Combined perioperative mortality and stroke rate were also evaluated (1.1% [stroke 0.9%, mortality 0.2%]).These results are very good and are comparable to what has been reported in the literature during the last few years. This observation provides further proof of the effectiveness of CEA in the management of extracranial carotid disease. Moreover, these results have to be taken into account when evaluating any new therapeutic options, such as carotid stenting, before accepting them as valid alternatives.

39. Early and long-term outcomes after open or endovascular repair for abdominal aortic aneurysms in high-risk patients

Author

Pane, B., Spinella, G., Alessio Signori, Musio, D., Perfumo, M. C., Lucertini, G., Rousas, N., and Palombo, D.

Subjects
Male, Time Factors, endovascular repair, Kaplan-Meier Estimate, high-risk patients, outcomes, survival, Blood Vessel Prosthesis Implantation, Risk Factors, Humans, abdominal aortic aneurysms, high-risk patients,endovascular repair,open repair, outcomes, survival, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, abdominal aortic aneurysms, Chi-Square Distribution, Patient Selection, Endovascular Procedures, Middle Aged, open repair, Survival Rate, Treatment Outcome, Multivariate Analysis, Female, Aortic Aneurysm, Abdominal
Abstract

The aim of our study was to evaluate the earlier and long term survival as well the postoperative complications in high-risk patients who received endovascular aortic repair (EVAR) as first choice, or open repair when anatomical requirements for EVAR were not met.Between January 2005 and January 2010, 593 patients underwent procedures for elective abdominal aortic aneurysm (AAA) repair; 172 of these were considered at high risk according to the American Society of Anesthesiology (ASA) score (ASA III and IV): 150 high-risk patients were males (mean age 72.7, range 53-93 years) and 22 females (mean age 72.9 years, range 60-90 years). The median AAA diameter was 64 (53-75) mm in the open repair group and 62 (55-70) mm in the EVAR group. 121 patients underwent open repair and 51 EVAR, respectively.The 30-day mortality rate was 0% in the EVAR group and 2.4% (3/121) in the open repair group (P=0.26). Long-term results showed: no EVAR-related mortality, no late conversion to open repair in the EVAR group was required during follow-up. No aneurysmal expansion was observed. In the open repair group, no graft-related events were observed during follow-up. The mean follow-up for survival analysis was 1542 days. Overall 5-year survival was 71.7% (SE=4.2%). Survival during follow-up was 92.2%, 86.1%, 76.2%, 65.9% and 61.8% at 12, 24,36,48,60 months respectively in EVAR Group. Open Group present long term survival of 95%, 88.9%, 83.9%, 79.7%, 76% at 12, 24, 36, 48, 60 months respectively.Our results in open repair surgery show a perioperative low mortality rate with high survival rate in long term. This result could be successfully achieved even in high-risk patients unsuitable for EVAR.

41. Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction.

Author

Palmieri, D., Barisione, C., Pane, B., Spinella, G., Garibaldi, S., Ghigliotti, G., Brunelli, C., Fulcheri, E., and Palombo, D.

Subjects
PHYSIOLOGICAL effects of resveratrol, ANTIOXIDANTS, AORTIC aneurysms, TUMOR necrosis factors, MONOCYTES
Abstract

Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L- monocyte subset, monocyte CD 143 surface expression, MMP-9 plasma activity and TNFOL serum levels were lower in Rsv-treated rats. In conclusion, Rsv acts as an anti-inflammatory compound and could be of great relevance to improve the immune response in AAA patients. [ABSTRACT FROM AUTHOR]

Published
2011
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42. Managing Peripheral Artery Disease in Diabetic Patients: A Questionnaire Survey from Vascular Centers of the Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS)

Author

G Bajardi, Francesco Setacci, Emad Hussein, Giancarlo Bracale, Olivier Goëau-Brissonnière, Ben R. Saleem, E Dinoto, Liborio Ferrante, Jamal J. Hoballah, Gianmarco de Donato, Maurizio Taurino, Bruno Gossetti, F Pecoraro, Bianca Pane, Anna Giribono, Raffaele Pulli, Vincenzo De Luca, Tarek Sraieb, Carlo Setacci, Andrea Stella, Umberto Bracale, Matteo Tozzi, Raffaele Pio Ammollo, Mohamed N. Bouayed, Patrizio Castelli, Maddalena Illario, Bracale U.M., Ammollo R.P., Hussein E.A., Hoballah J.J., Goeau-Brissonniere O., Taurino M., Setacci C., Pecoraro F., Bracale G., Giribono A.M., Ferrante L., de Donato G., Dinoto E., Bajardi G., Illario M., Bouayed M.N., Saleem B.R., Pulli R., Gossetti B., Pane B., Castelli P., Tozzi M., Sraieb T., Setacci F., Stella A., De Luca V., Bracale, Umberto Marcello, Ammollo, Raffaele Pio, Hussein, Emad A, Hoballah, Jamal J, Goeau-Brissonniere, Olivier, Taurino, Maurizio, Setacci, Carlo, Pecoraro, Felice, and Bracale, Giancarlo

Subjects
medicine.medical_treatment, Psychological intervention, 030204 cardiovascular system & hematology, vascular surgery, Settore MED/22 - Chirurgia Vascolare, 030218 nuclear medicine & medical imaging, Wound care, 0302 clinical medicine, Ischemia, Practice Patterns, Physicians', Response rate (survey), Practice Patterns, Nurses', diabetes, Mediterranean Region, Endovascular Procedures, vascular medicine, General Medicine, Treatment Outcome, Cardiology and Cardiovascular Medicine, Vascular Surgical Procedures, diabetic foot, management, Specialization, Reoperation, medicine.medical_specialty, Revascularization, Nurse's Role, Amputation, Surgical, 03 medical and health sciences, peripheral arterial disease, Mediterranean Sea, medicine, Humans, Training, Healthcare Disparities, Endovascular Surgery, Vascular Surgery, Physician's Role, Patient Care Team, Wound Healing, business.industry, General surgery, Vascular surgery, medicine.disease, Diabetic foot, Amputation, Health Care Surveys, Orthopedic surgery, Surgery, business, wound care
Abstract

Background The Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS) was founded on October 1, 2018, to enhance cooperation among vascular professionals within Mediterranean countries. Due to its prominent social and economic impact on national health systems, diabetic arteriopathy has been selected as the very first topic to be investigated by the federation. Methods MeFAVS members were asked to reply to a questionnaire on the management of diabetic ischemic foot. Results were collected and analyzed statistically. The questionnaire consisted of 15 multiple choice answers regarding diabetic foot (DF) diagnosis and treatment. The questionnaire was submitted to 21 centers on April 20, 2019. Results Response rate was 62%. The survey revealed that vascular surgeons, diabetologists, and wound care nurses made-up the core of the diabetic teams present in 76.9%, 69.3%, and 92.3% of the centers, respectively. Diabetic teams were most often led by vascular surgeons (53.8%) and diabetologists (42.2%), but only in 7.9% of cases by nurses. Duplex ultrasonography and computed tomographic angiography were the most commonly available tools used to assess diabetic peripheral arterial disease (PAD). Surgical wound care was undertaken by vascular surgeons in the majority of cases, and only in 46.2% of the cases to orthopedic or plastic surgeons, while nonsurgical wound care was handled by specialized nurses (76.6%) and diabetologists (53.8%). First-line revascularization was preferred over conservative treatment (61.5% vs 53.8%) and endovascular strategy (45.3%) over open (33.7%) or hybrid (21.0%) surgery. Vascular surgeons and interventional radiologists were found to be the most common performers of endovascular revascularization (92.3% and 53.8%, respectively). Amputations had an overall rate of 16.6% (range 4–30%) and a mean reintervention rate of 22.5%, and were usually performed by vascular surgeons for both minor and major interventions (84.6%) followed by orthopedic surgeons (15.4% minor and 30.8% major). The availability of a DF clinic (84.6%) and endovascular (53.8%) and open surgery (46.2%) capabilities were considered fundamental to reduce amputation rates. Conclusions Especially since the introduction and spreading of new endovascular techniques for the treatment of DF, it is a common consensus amongst vascular surgeons that a standardized approach to the discipline is necessary in order to improve outcomes such as amputation-free survival and mortality and it is with this perspective and purpose that transnational cooperation amongst vascular professionals and residents in training are aiming for greater proficiency in endovascular and open surgery.

Published
2020
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43. Ficolin-2 serum levels predict the occurrence of acute coronary syndrome in patients with severe carotid artery stenosis

Author

Maria Bertolotto, Fabrizio Montecucco, Giovanni Spinella, Maria Grazia De Simoni, Carlo Perego, Bianca Pane, Federico Carbone, Alessia Valente, Stefano Fumagalli, Domenico Palombo, Carbone, F, Valente, A, Perego, C, Bertolotto, M, Pane, B, Spinella, G, Palombo, D, De Simoni, M, Montecucco, F, and Fumagalli, S

Subjects
0301 basic medicine, Male, Complement system, medicine.medical_treatment, Immunofluorescence, 03 medical and health sciences, 0302 clinical medicine, Lectins, Atherosclerosis, biomarkers, complement system, plaque vulnerability, Medicine, Humans, Carotid Stenosis, Acute Coronary Syndrome, Plaque vulnerability, Complement Activation, Endarterectomy, Aged, Pharmacology, Inflammation, biology, medicine.diagnostic_test, business.industry, Hazard ratio, Biomarker, Prognosis, 030104 developmental biology, 030220 oncology & carcinogenesis, Lectin pathway, Neutrophil elastase, Atherosclerosi, Immunology, biology.protein, Biomarker (medicine), Female, business, Ficolin
Abstract

Background and purpose erosion of vulnerable atherosclerotic plaques may cause life-threatening thromboembolic complications. There is indeed an urgent need to recognize a clear-cut biomarker able to identify vulnerable plaques. Here, we focused on circulating proteins belonging to the lectin pathway (LP) of complement activation. Methods we analyzed mannose-binding lectin (MBL), ficolin-1, -2 and -3 (LP initiators) levels by ELISA in sera from n = 240 of an already published cohort of patients undergoing endarterectomy for severe carotid stenosis and followed-up until 18 months after surgery. Immunofluorescence followed by confocal and polarized light microscopy was used to detect LP initiator intraplaque localization. Spearman’s rank test was drawn to investigate correlation between serum LP levels and circulating inflammatory proteins or intraplaque components. Survival analyses were then performed to test the predictive role of LP on long-term adverse outcome. Results ficolins, but not MBL, correlated positively with 1) high circulating levels of inflammatory markers, including MPO, MMP-8, MMP-9, ICAM-1, osteopontin, neutrophil elastase, and; 2) immune cell intraplaque recruitment. Immunofluorescence showed ficolins in calcified plaques and ficolin-2 in cholesterol-enriched plaque regions in association with macrophages. In the multivariate survival analysis, ficolin-2 serum levels predicted a major adverse cardiovascular event during the follow-up, independently of symptomatic status and inflammatory markers (hazard ratio 38.6 [95 % CI 3.9–385.2]). Conclusions ficolins support intraplaque immune cell recruitment and inflammatory processes ultimately leading to plaque vulnerability. Especially for ficolin-2 a strong predictive value toward adverse cardiovascular events was demonstrated. This evidence offers potentially new pharmacological target to dampen the inflammatory mechanisms leading to plaque vulnerability.

Published
2020

45. Use of health-related quality-of-life measurements to estimate individuals' health on screening

Author

Lorenzo G. Mantovani, Luciana Scalone, Giancarlo Cesana, Bianca Pane, Giovanni Spinella, Paolo Cortesi, Domenico Palombo, Scalone, L, Cortesi, Pa, Spinella, G, Pane, B, Cesana, G, Mantovani, LORENZO GIOVANNI, Palombo, D., Cortesi, P, Mantovani, L, and Palombo, D

Subjects
Male, medicine.medical_specialty, Health Status, Population, Psychological intervention, Age and sex, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Risk Factors, Surveys and Questionnaires, medicine, Screening programs, Humans, Mass Screening, 030212 general & internal medicine, education, Aged, Aged, 80 and over, Health related quality of life, education.field_of_study, business.industry, screening, 030503 health policy & services, General Medicine, humanities, Quality of Life, Physical therapy, Female, Surgery, 0305 other medical science, Large group, business, Aortic Aneurysm, Abdominal
Abstract

Objectives: to investigate the utility of assessing Health-Related Quality of Life (HRQoL) in a large group of subjects participating in a screening program for aneurysm and the relationship between HRQoL, diagnosis of aneurysm and related risk factors. Methods: subjects involved in this screening program were submitted the EQ-5D questionnaire to report their own HRQoL. HRQoL was reported also a second time by the subjects who were diagnosed with aneurysm during screening and who returned for a monitoring follow up visit a few months later. We evaluated compliance with HRQoL data collection and performed multiple regression analyses in order to investigate the possible relationship between demographic and clinical data with HRQoL. Results: 1,633 subjects screened (6.1% diagnosed with aneurysm) and 125 subjects diagnosed with aneurysm and attending a follow-up visit reported their HRQoL. Completion of the EQ-5D questionnaire was well accepted by both physicians-and-subjects-undergoing-screening.-HRQoL- was-not-significantly-different-between-the-screening-and-followup visits, on adjusting for age and sex. At the screening visit, HRQoL was associated with ASA class, heart condition, BMI-and-respiratory-diseases.-No-associations-were- found-at-the-follow-up-visit. Conclusion: Assessing HRQoL in screening programs is feasible and well accepted and add useful information on health of large numbers of subjects from general population. This could be considered as a routine approach to optimizing the informative role of screening programs in guiding other investigations or interventions.

46. Assessment of the Aorto-Septal Angle Post-Thoracic Endovascular Aortic Repair through Segmentation and the Semi-Automatic Analysis of Cardiosynchronized Computed Tomography Angiography Images.

Author

Magliocco M, Conti M, Pane B, Canepa M, Seitun S, Morganti S, Pratesi G, and Spinella G

Abstract

The aim of this study was to inviestigate cardiac and arterial remodelling before and after thoracic endovascular aortic repair (TEVAR) by measuring the Aorto-Septal Angle (AoSA) and the geometric characteristics of the aorta. Five patients were prospectively included. Pre- and post-operative cardio-CTA scans were used to create patient-specific 3D models to calculate the AoSA, defined by the intersection of the aortic and left ventricular axes. Additionally, geometric parameters and the inclination of the ascending aorta (AA) were measured. The results demonstrated a variation between pre- and post-operative AoSA in all patients, with an increase in the case of an aneurysmal disease from 112.36° ± 8.21° to 117.16° ± 9.65° (+4.1%, p = 0.041) and a decrease in the case of aortic dissection from 113.62° ± 0.96° to 107.83° ± 1.45° (-5.1%). Additionally, an increase in the length of both the outer and inner curvatures of the AA was observed from 102.21 ± 10.17 mm to 105.73 ± 11.2 mm (+ 3.33% p = 0.016) and from 55.55 ± 9.53 mm to 58.35 ± 9.96 mm (+4.8%, p = 0.04), respectively. This study introduced a new repeatable and reproducible method for assessing the AoSA using cardiac-CTA images. Thoracic stent deployment changes the AoSA, potentially impacting long-term left ventricle hemodynamics.

Published
2024
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47. Early Experience of Inner Branch Retrograde Cannulation With E-nside Branch Stent Graft for Thoracoabdominal Aortic Aneurysms.

Author

Spinella G, Pane B, Finotello A, Bastianon M, Mena Vera JM, Di Gregorio S, and Pratesi G

Subjects
Humans, Male, Retrospective Studies, Treatment Outcome, Aged, Female, Aged, 80 and over, Time Factors, Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic surgery, Aortic Aneurysm, Thoracic diagnostic imaging, Aortic Aneurysm, Thoracic mortality, Aortic Aneurysm, Thoracic physiopathology, Stents, Endovascular Procedures instrumentation, Endovascular Procedures adverse effects, Blood Vessel Prosthesis Implantation instrumentation, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis, Prosthesis Design, Feasibility Studies
Abstract

Purpose: The aim of our study is to investigate the feasibility of retrograde cannulation using devices with inner branches (IB) for the endovascular treatment of thoracoabdominal aortic aneurysms (TAAAs)., Materials and Methods: A retrospective analysis using IB configuration with retrograde cannulation was carried out on TAAAs patients undergoing endovascular treatment., Results: Seven patients underwent IB endovascular treatment with retrograde cannulation between September 2020 and November 2021. The mean age was 80.4 years and 4 patients were male. A total of 26 of 28 target vessels were cannulated by retrograde access with a technical success of 93% (2 of 26 target vessels). Two intra-procedural complications were observed (1 renal artery dissection and 1 collateral renal artery rupture). In total, 26 of 28 treated vessels were retrograde cannulated with a technical success of 93%. A total of 39 stent bridges were used (all Viabahn VBX devices). The mean duration of the procedure was 321±102 minutes, and the mean scan time was 134±62 minutes. Mortality at 30 days was observed in 1 case. During the follow-up, 1 stent bridge occlusion was observed without the need for reintervention., Conclusion: Retrograde cannulation can also be successfully performed in the case of inner branches., Clinical Impact: In inner branched cases, retrograde cannulation should be taken into consideration in particular cases or it could become the option of choice. Dedicated endovascular material available such as steerable catheters and latest generation covered stents is fundamental for the success of the treatment., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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48. The Impact of Knee Bending on the Superficial Femoral Artery and Popliteal Artery Morphology Before and After Endovascular Repair of Popliteal Aneurysm.

Author

Spinella G, Magliocco M, Pane B, Salsano G, Cittadini G, Pisa FR, and Conti M

Abstract

Objective: The aim of this study is to evaluate the deformations of the femoropopliteal (FP) arterial segment due to knee flexion in patients suffering from popliteal aneurysm before and after endovascular treatment (ET)., Design and Methods: Nine patients were prospectively evaluated. Pre-operative and post-operative computed tomography angiography (CTA) scans were performed on the leg of each patient in both a flexed and extended knee position. The images were employed to reconstruct the FP segment through segmentation and the resulting models were subsequently used to calculate the average diameter, length, and tortuosity of both the superficial femoral artery (SFA) and popliteal artery (PA). Furthermore, the overall PA tortuosity was decomposed into 2 components, ie, antero-posterior and lateral direction., Results: Following knee flexion, both arterial segments experienced shortening in the pre-operative and post-operative phases. Specifically, the SFA was shortened by 3.5% in pre (p<0.001) and 1.21% in post-stenting (p<0.001), while the PA was shortened by 4.8% (p<0.001) and 5.63% (p<0.001), respectively. Tortuosity significantly increased in all considered segments; in particular, in SFA there was a pre-intervention increase of 85.2% (p=0.002) and an increase of 100% post-intervention (p=0.004), whereas in the PA, there was an increase of 128.9% (p<0.001) and 254.8% (p<0.001), respectively. The only diameter variation occurred in the SFA pre-operatively with an increase of 11.9% (p=0.007). Tortuosity decomposition revealed significant differences between the 2 planes during the pre-operative and post-operative phases in both extended and flexed configurations, confirming a change in artery position and geometry due to treatment., Conclusions: Knee flexion induces arterial shortening and increased tortuosity in both the pre- and post-operative configuration. Stent placement does not induce significant geometric differences between pre-treatment and post-treatment. These results seem to indicate that the geometry of the covered stent is not affected by the flexion of the knee joint. Despite this, a more detailed analysis of arterial tortuosity showed a change in artery deformation following treatment., Clinical Impact: This study aimed to evaluate femoropopliteal arterial deformations in nine patients with popliteal aneurysm before and after endovascular treatment (ET) during knee flexion, using a standardized protocol for CTA acquisition and analysis. The result can be useful in procedure planning and have shown that the Viabahn stent used can adapt to the morphological variations induced by limb flexion. Consequently, device failure does not be attributed to stent compression but rather to other factors, such as alterations in hemodynamic and biomechanical forces on the implant due to the significant changes in tortuosity observed, or biological causes., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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49. Reconsidering the Impact of Endovascular Repair on Short-Term and Mid-Term Outcomes in Peripheral Arterial Disease: A Retrospective Analysis.

Author

Spinella G, Pisa FR, Boschetti GA, Finotello A, Pane B, Pratesi G, and Lanzarone E

Subjects
Humans, Retrospective Studies, Female, Male, Aged, Time Factors, Treatment Outcome, Middle Aged, Risk Factors, Aged, 80 and over, Risk Assessment, Peripheral Arterial Disease mortality, Peripheral Arterial Disease surgery, Peripheral Arterial Disease diagnosis, Endovascular Procedures adverse effects, Endovascular Procedures mortality, Amputation, Surgical, Limb Salvage
Abstract

Background: The aim of the study is to compare the short-term and medium-term outcomes in patients who underwent open repair (OR) or endovascular repair (ER) for peripheral arterial disease (PAD) also including stratifications based on severity and year of the first intervention., Methods: We conducted an observational retrospective single-center cohort study. We evaluated patients with PAD that primarily underwent ER, OR, minor, and major amputations in a single center from 2005 to 2020. The patients were then subdivided according to the type of intervention (OR versus ER), and stratified according to the International Classification of Diseases 9 code reported in the operating documents and to the year intervention. Mortality, minor, and major amputation rates occurring at 30 days, 2 years, and 5 years after the first intervention were evaluated as primary outcomes and compared between patient groups in both stratifications. Moreover, Kaplan-Maier curves were analyzed for these outcomes., Results: One thousand four hundred ninety two patients (67.0% males) with PAD were evaluated. Their clinical presentations were intermittent claudication in 51.4% of cases, rest pain in 16.8%, ulcers in 10.3%, and gangrene in 21.5%. Nine hundred ninety seven (66.8%) underwent OR and 495 (33.2%) ER as first intervention for PAD. No statistical differences were observed in terms of mortality in the 2 groups (OR versus ER, P = 1,000, P = 0.357, and P = 0.688 at 30 days, 2 years, and 5 years, respectively). The rate of minor amputations was significantly higher (P < 0.012, P < 0.002, and P < 0.007 at 30 days, 2 years, and 5 years, respectively) for ER group in any of the observed follow-up periods. Also, we have observed that OR and ER do not have any significant short-term and medium-term major amputation rate differences., Conclusions: In our experience, the impact of ER does not significantly change short-term and mid-term major outcomes in patients with PAD., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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50. Artificial Intelligence Application to Screen Abdominal Aortic Aneurysm Using Computed tomography Angiography.

Author

Spinella G, Fantazzini A, Finotello A, Vincenzi E, Boschetti GA, Brutti F, Magliocco M, Pane B, Basso C, and Conti M

Subjects
Humans, Artificial Intelligence, Retrospective Studies, Tomography, X-Ray Computed, Computed Tomography Angiography methods, Aortic Aneurysm, Abdominal diagnostic imaging
Abstract

The aim of our study is to validate a totally automated deep learning (DL)-based segmentation pipeline to screen abdominal aortic aneurysms (AAA) in computed tomography angiography (CTA) scans. We retrospectively evaluated 73 thoraco-abdominal CTAs (48 AAA and 25 control CTA) by means of a DL-based segmentation pipeline built on a 2.5D convolutional neural network (CNN) architecture to segment lumen and thrombus of the aorta. The maximum aortic diameter of the abdominal tract was compared using a threshold value (30 mm). Blinded manual measurements from a radiologist were done in order to create a true comparison. The screening pipeline was tested on 48 patients with aneurysm and 25 without aneurysm. The average diameter manually measured was 51.1 ± 14.4 mm for patients with aneurysms and 21.7 ± 3.6 mm for patients without aneurysms. The pipeline correctly classified 47 AAA out of 48 and 24 control patients out of 25 with 97% accuracy, 98% sensitivity, and 96% specificity. The automated pipeline of aneurysm measurements in the abdominal tract reported a median error with regard to the maximum abdominal diameter measurement of 1.3 mm. Our approach allowed for the maximum diameter of 51.2 ± 14.3 mm in patients with aneurysm and 22.0 ± 4.0 mm in patients without an aneurysm. The DL-based screening for AAA is a feasible and accurate method, calling for further validation using a larger pool of diagnostic images towards its clinical use., (© 2023. The Author(s).)

Published
2023
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