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9 results on '"Pandita, Ravina"'

3. Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo

Author

Khazan, Negar, primary, Kim, Kyu Kwang, additional, Hansen, Jeanne N., additional, Singh, Niloy A., additional, Moore, Taylor, additional, Snyder, Cameron W. A., additional, Pandita, Ravina, additional, Strawderman, Myla, additional, Fujihara, Michiko, additional, Takamura, Yuta, additional, Jian, Ye, additional, Battaglia, Nicholas, additional, Yano, Naohiro, additional, Teramoto, Yuki, additional, Arnold, Leggy A., additional, Hopson, Russell, additional, Kishor, Keshav, additional, Nayak, Sneha, additional, Ojha, Debasmita, additional, Sharon, Ashoke, additional, Ashton, John M., additional, Wang, Jian, additional, Milano, Michael T., additional, Miyamoto, Hiroshi, additional, Linehan, David C., additional, Gerber, Scott A., additional, Kawar, Nada, additional, Singh, Ajay P., additional, Tabdanov, Erdem D., additional, Dokholyan, Nikolay V., additional, Kakuta, Hiroki, additional, Jurutka, Peter W., additional, Schor, Nina F., additional, Rowswell-Turner, Rachael B., additional, Singh, Rakesh K., additional, and Moore, Richard G., additional

Published
2022
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4. BET inhibitors rescue anti-PD1 resistance by enhancing TCF7 accessibility in leukemia-derived terminally exhausted CD8+T cells

Author

Romine, Kyle A., MacPherson, Kevin, Cho, Hyun-jun, Kosaka, Yoko, Flynn, Patrick A., Byrd, Kaelan H., Coy, Jesse L., Newman, Matthew T., Pandita, Ravina, Loo, Christopher P., Scott, Jaime, Adey, Andrew C., and Lind, Evan F.

Abstract

Many acute myeloid leukemia (AML) patients exhibit hallmarks of immune exhaustion, such as increased myeloid-derived suppressor cells, suppressive regulatory T cells and dysfunctional T cells. Similarly, we have identified the same immune-related features, including exhausted CD8+T cells (TEx) in a mouse model of AML. Here we show that inhibitors that target bromodomain and extra-terminal domain (BET) proteins affect tumor-intrinsic factors but also rescue T cell exhaustion and ICB resistance. Ex vivo treatment of cells from AML mice and AML patients with BET inhibitors (BETi) reversed CD8+T cell exhaustion by restoring proliferative capacity and expansion of the more functional precursor-exhausted T cells. This reversal was enhanced by combined BETi and anti-PD1 treatment. BETi synergized with anti-PD1 in vivo, resulting in the reduction of circulating leukemia cells, enrichment of CD8+T cells in the bone marrow, and increase in expression of Tcf7, Slamf6, and Cxcr5in CD8+T cells. Finally, we profiled the epigenomes of in vivo JQ1-treated AML-derived CD8+T cells by single-cell ATAC-seq and found that JQ1 increases Tcf7accessibility specifically in Tex cells, suggesting that BETi likely acts mechanistically by relieving repression of progenitor programs in Tex CD8+T cells and maintaining a pool of anti-PD1 responsive CD8+T cells.

Published
2023
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5. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression

Author

Rowswell-Turner, Rachael B., primary, Singh, Rakesh K., additional, Urh, Anze, additional, Yano, Naohiro, additional, Kim, Kyu Kwang, additional, Khazan, Negar, additional, Pandita, Ravina, additional, Sivagnanalingam, Umayal, additional, Hovanesian, Virginia, additional, James, Nicole E., additional, Ribeiro, Jennifer R., additional, Kadambi, Sindhuja, additional, Linehan, David C., additional, and Moore, Richard G., additional

Published
2021
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7. Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently

Author

Singh, Rakesh K., primary, Kim, KyuKwang, additional, Rowswell-Turner, Rachael B., additional, Hansen, Jeanne N., additional, Khazan, Negar, additional, Jones, Aaron, additional, Sivagnanalingam, Umayal, additional, Teramoto, Yuki, additional, Goto, Takuro, additional, Jian, Ye, additional, Battaglia, Nicholas, additional, Conley, Thomas, additional, Hovanesian, Virginia, additional, Yano, Naohiro, additional, Pandita, Ravina, additional, Arnold, Leggy A., additional, Hopson, Russel, additional, Ojha, Debasmita, additional, Sharon, Ashoke, additional, Ashton, John, additional, Miyamoto, Hiroshi, additional, Schor, Nina F., additional, Milano, Michael T., additional, Linehan, David C., additional, Gerber, Scott A., additional, and Moore, Richard G., additional

Published
2020
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9. Septins disruption controls tumor growth and enhances efficacy of Herceptin

Author

Singh, Rakesh K, primary, Kim, Kyu Kwang, additional, Khazan, Negar, additional, Rowswell-Turner, Rachael B., additional, Laggner, Christian, additional, Jones, Aaron, additional, Srivastava, Priyanka, additional, Hovanesian, Virginia, additional, Lamere, Liz, additional, Conley, Thomas, additional, Pandita, Ravina, additional, Baker, Cameron, additional, Myers, Jason R, additional, Pritchett, Elizabeth, additional, Ahmad, Awada, additional, Ruffolo, Luis, additional, Jackson, Katherine, additional, Gerber, Scott A., additional, Ashton, John, additional, Milano, Michael T., additional, Linehan, David, additional, and Moore, Richard G, additional

Published
2020
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