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9 results on '"Pandini, Marta"'

1. C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer

Author

Portale, Federica, Carriero, Roberta, Iovino, Marta, Kunderfranco, Paolo, Pandini, Marta, Marelli, Giulia, Morina, Nicolò, Lazzeri, Massimo, Casale, Paolo, Colombo, Piergiuseppe, De Simone, Gabriele, Camisaschi, Chiara, Lugli, Enrico, Basso, Gianluca, Cibella, Javier, Marchini, Sergio, Bordi, Matteo, Meregalli, Greta, Garbin, Anna, Dambra, Monica, Magrini, Elena, Rackwitz, Wiebke, Cecconi, Francesco, Corbelli, Alessandro, Fiordaliso, Fabio, Eitler, Jiri, Tonn, Torsten, and Di Mitri, Diletta

Published
2024
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2. Preclinical efficacy of carfilzomib in BRAF‐mutant colorectal cancer models

Author

Maione, Federica, primary, Oddo, Daniele, additional, Galvagno, Federica, additional, Falcomatà, Chiara, additional, Pandini, Marta, additional, Macagno, Marco, additional, Pessei, Valeria, additional, Barault, Ludovic, additional, Gigliotti, Chiara, additional, Mira, Alessia, additional, Corti, Giorgio, additional, Lamba, Simona, additional, Riganti, Chiara, additional, Castella, Barbara, additional, Massaia, Massimo, additional, Rad, Roland, additional, Saur, Dieter, additional, Bardelli, Alberto, additional, and Di Nicolantonio, Federica, additional

Published
2024
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3. MP14-11 SINGLE CELL-BASED IMMUNE PROFILING OF THE TUMOR AND ITS IMMUNE MICROENVIRONMENT REVEALED DIFFERENCES BETWEEN NMIBC AND MIBC: IMPLICATION FOR IMMUNO-THERAPY

Author

Lazzeri, Massimo, primary, Buffi, NicolòMaria, additional, Lughezzani, Giovanni, additional, Casale, Paolo, additional, Hurle, Roberto, additional, Saita, Alberto, additional, Fasulo, Vittorio, additional, Paciotti, Marco, additional, Pandini, Marta, additional, Carriero, Roberta, additional, Carvetta, Mattia, additional, Iovino, Marta, additional, Colombo, Piergiuseppe, additional, Elefante, Grazia, additional, Basso, Gianluca, additional, Marchini, Sergio, additional, Kunderfranco, Paolo, additional, and Di Mitri, Diletta, additional

Published
2023
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4. Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein

Author

Marini, Elisabetta, primary, Marino, Marco, additional, Gionfriddo, Giulia, additional, Maione, Federica, additional, Pandini, Marta, additional, Oddo, Daniele, additional, Giorgis, Marta, additional, Rolando, Barbara, additional, Blua, Federica, additional, Gastaldi, Simone, additional, Marchiò, Serena, additional, Kovachka, Sandra, additional, Spyrakis, Francesca, additional, Gianquinto, Eleonora, additional, Di Nicolantonio, Federica, additional, and Bertinaria, Massimo, additional

Published
2022
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6. Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer

Author

Masetti, Michela, primary, Carriero, Roberta, additional, Portale, Federica, additional, Marelli, Giulia, additional, Morina, Nicolò, additional, Pandini, Marta, additional, Iovino, Marta, additional, Partini, Bianca, additional, Erreni, Marco, additional, Ponzetta, Andrea, additional, Magrini, Elena, additional, Colombo, Piergiuseppe, additional, Elefante, Grazia, additional, Colombo, Federico Simone, additional, den Haan, Joke M.M., additional, Peano, Clelia, additional, Cibella, Javier, additional, Termanini, Alberto, additional, Kunderfranco, Paolo, additional, Brummelman, Jolanda, additional, Chung, Matthew Wai Heng, additional, Lazzeri, Massimo, additional, Hurle, Rodolfo, additional, Casale, Paolo, additional, Lugli, Enrico, additional, DePinho, Ronald A., additional, Mukhopadhyay, Subhankar, additional, Gordon, Siamon, additional, and Di Mitri, Diletta, additional

Published
2021
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7. Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF V600E Protein.

Author

Marini, Elisabetta, Marino, Marco, Gionfriddo, Giulia, Maione, Federica, Pandini, Marta, Oddo, Daniele, Giorgis, Marta, Rolando, Barbara, Blua, Federica, Gastaldi, Simone, Marchiò, Serena, Kovachka, Sandra, Spyrakis, Francesca, Gianquinto, Eleonora, Di Nicolantonio, Federica, and Bertinaria, Massimo

Subjects
BRAF genes, SERINE/THREONINE kinases, CELL proliferation, CELL communication, CHEMICAL synthesis, KINASE inhibitors
Abstract

BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAFV600E mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resistance mechanisms. The PROTAC-induced degradation of BRAFV600E has been proposed as an alternative strategy to avoid the onset of resistance. In this study, we designed a series of compounds where the BRAF kinase inhibitor encorafenib was conjugated to pomalidomide through different linkers. The synthesized compounds maintained their ability to inhibit the kinase activity of mutated BRAF with IC50 values in the 40–88 nM range. Selected compounds inhibited BRAFV600E signaling and cellular proliferation of A375 and Colo205 tumor cell lines. Compounds 10 and 11, the most active of the series, were not able to induce degradation of mutated BRAF. Docking and molecular dynamic studies, conducted in comparison with the efficient BRAF degrader P5B, suggest that a different orientation of the linker bearing the pomalidomide substructure, together with a decreased mobility of the solvent-exposed part of the conjugates, could explain this behavior. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer

Author

Masetti, Michela, Carriero, Roberta, Portale, Federica, Marelli, Giulia, Morina, Nicolò, Pandini, Marta, Iovino, Marta, Partini, Bianca, Erreni, Marco, Ponzetta, Andrea, Magrini, Elena, Colombo, Piergiuseppe, Elefante, Grazia, Colombo, Federico Simone, den Haan, Joke M.M., Peano, Clelia, Cibella, Javier, Termanini, Alberto, Kunderfranco, Paolo, Brummelman, Jolanda, Chung, Matthew Wai Heng, Lazzeri, Massimo, Hurle, Rodolfo, Casale, Paolo, Lugli, Enrico, DePinho, Ronald A., Mukhopadhyay, Subhankar, Gordon, Siamon, and Di Mitri, Diletta

Abstract

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing was used to profile the transcriptional landscape of TAMs in human PCa, leading to identification of a subset of macrophages characterized by dysregulation in transcriptional pathways associated with lipid metabolism. This subset of TAMs correlates positively with PCa progression and shorter disease-free survival and is characterized by an accumulation of lipids that is dependent on Marco. Mechanistically, cancer cell–derived IL-1β enhances Marco expression on macrophages, and reciprocally, cancer cell migration is promoted by CCL6 released by lipid-loaded TAMs. Moreover, administration of a high-fat diet to tumor-bearing mice raises the abundance of lipid-loaded TAMs. Finally, targeting lipid accumulation by Marco blockade hinders tumor growth and invasiveness and improves the efficacy of chemotherapy in models of PCa, pointing to combinatorial strategies that may influence patient outcomes.

Published
2022
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9. Heterotypic signaling between tumor cells and lipid-loaded macrophages drives tumor progression and resistance to therapy in cancer

Author

Masetti, Michela, Carriero, Roberta, Portale, Federica, Marelli, Giulia, Nicolò Morina, Pandini, Marta, Iovino, Marta, Ponzetta, Andrea, Magrini, Elena, Colombo, Piergiuseppe, Den Joke, Haan Jmm, Peano, Clelia, Cibella, Javier, Kunderfranco, Paolo, Lazzeri, Massimo, Hurle, Rodolfo, Casale, Paolo, Brummelmann, Jolanda, Lugli, Enrico, Mukhopadhyay, Subhankar, Depinho, Ronald, Gordon, Siamon, and Di Mitri, Diletta

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