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1. Epigenetic signals associated with delirium replicated across four independent cohorts

Author

Nishizawa, Yoshitaka, Thompson, Kaitlyn C., Yamanashi, Takehiko, Wahba, Nadia E., Saito, Taku, Marra, Pedro S., Nagao, Takaaki, Nishiguchi, Tsuyoshi, Shibata, Kazuki, Yamanishi, Kyosuke, Hughes, Christopher G., Pandharipande, Pratik, Cho, Hyunkeun, Howard, III, Matthew A., Kawasaki, Hiroto, Toda, Hiroyuki, Kanazawa, Tetsufumi, Iwata, Masaaki, and Shinozaki, Gen

Published
2024
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3. Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial.

Author

Nordness, Mina, Maiga, Amelia, Wilson, Laura, Koyama, Tatsuki, Rivera, Erika, Rakhit, Shayan, de Riesthal, Michael, Motuzas, Cari, Cook, Madison, Gupta, Deepak, Jackson, James, Williams Roberson, Shawniqua, Meurer, William, Lewis, Roger, Manley, Geoffrey, Pandharipande, Pratik, and Patel, Mayur

Subjects
Adrenergic blockade, Critical care, Paroxysmal sympathetic hyperactivity, Traumatic brain injury, Humans, Propranolol, Clonidine, Pilot Projects, Treatment Outcome, Brain Injuries, Traumatic, Adrenergic Agents
Abstract

OBJECTIVE: To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol and clonidine in patients with severe traumatic brain injury (TBI). BACKGROUND: Administration of adrenergic blockade after severe TBI is common. To date, no prospective trial has rigorously evaluated this common therapy for benefit. METHODS: This phase II, single-center, double-blinded, pilot randomized placebo-controlled trial included patients aged 16-64 years with severe TBI (intracranial hemorrhage and Glasgow Coma Scale score ≤ 8) within 24 h of ICU admission. Patients received propranolol and clonidine or double placebo for 7 days. The primary outcome was ventilator-free days (VFDs) at 28 days. Secondary outcomes included catecholamine levels, hospital length of stay, mortality, and long-term functional status. A planned futility assessment was performed mid-study. RESULTS: Dose compliance was 99%, blinding was intact, and no open-label agents were used. No treatment patient experienced dysrhythmia, myocardial infarction, or cardiac arrest. The study was stopped for futility after enrolling 47 patients (26 placebo, 21 treatment), per a priori stopping rules. There was no significant difference in VFDs between treatment and control groups [0.3 days, 95% CI (- 5.4, 5.8), p = 1.0]. Other than improvement of features related to sympathetic hyperactivity (mean difference in Clinical Features Scale (CFS) 1.7 points, CI (0.4, 2.9), p = 0.012), there were no between-group differences in the secondary outcomes. CONCLUSION: Despite the safety and feasibility of adrenergic blockade with propranolol and clonidine after severe TBI, the intervention did not alter the VFD outcome. Given the widespread use of these agents in TBI care, a multi-center investigation is warranted to determine whether adrenergic blockade is of therapeutic benefit in patients with severe TBI. Trial Registration Number NCT01322048.

Published
2023

4. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial

Author

Mart, Matthew F, Boehm, Leanne M, Kiehl, Amy L, Gong, Michelle N, Malhotra, Atul, Owens, Robert L, Khan, Babar A, Pisani, Margaret A, Schmidt, Gregory A, Hite, R Duncan, Exline, Matthew C, Carson, Shannon S, Hough, Catherine L, Rock, Peter, Douglas, Ivor S, Feinstein, Daniel J, Hyzy, Robert C, Schweickert, William D, Bowton, David L, Masica, Andrew, Orun, Onur M, Raman, Rameela, Pun, Brenda T, Strength, Cayce, Rolfsen, Mark L, Pandharipande, Pratik P, Brummel, Nathan E, Hughes, Christopher G, Patel, Mayur B, Stollings, Joanna L, Ely, E Wesley, Jackson, James C, and Girard, Timothy D

Published
2024
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5. Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III

Author

Ward, Denham S, Absalom, Anthony R, Aitken, Leanne M, Balas, Michele C, Brown, David L, Burry, Lisa, Colantuoni, Elizabeth, Coursin, Douglas, Devlin, John W, Dexter, Franklin, Dworkin, Robert H, Egan, Talmage D, Elliott, Doug, Egerod, Ingrid, Flood, Pamela, Fraser, Gilles L, Girard, Timothy D, Gozal, David, Hopkins, Ramona O, Kress, John, Maze, Mervyn, Needham, Dale M, Pandharipande, Pratik, Riker, Richard, Sessler, Daniel I, Shafer, Steven L, Shehabi, Yahya, Spies, Claudia, Sun, Lena S, Tung, Avery, and Urman, Richard D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Patient Safety, Generic health relevance, Quality Education, Congresses as Topic, Consensus, Delphi Technique, District of Columbia, Humans, Hypnotics and Sedatives, Respiration, Artificial, Time Factors, clinical trial, intensive care, outcome assessments, research methodology, sedation, Nursing, Public Health and Health Services, Emergency & Critical Care Medicine, Clinical sciences
Abstract

ObjectivesClinical trials evaluating the safety and effectiveness of sedative medication use in critically ill adults undergoing mechanical ventilation differ considerably in their methodological approach. This heterogeneity impedes the ability to compare results across studies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations convened a meeting of multidisciplinary experts to develop recommendations for key methodologic elements of sedation trials in the ICU to help guide academic and industry clinical investigators.DesignA 2-day in-person meeting was held in Washington, DC, on March 28-29, 2019, followed by a three-round, online modified Delphi consensus process.ParticipantsThirty-six participants from academia, industry, and the Food and Drug Administration with expertise in relevant content areas, including two former ICU patients attended the in-person meeting, and the majority completed an online follow-up survey and participated in the modified Delphi process.Measurements and main resultsThe final recommendations were iteratively refined based on the survey results, participants' reactions to those results, summaries written by panel moderators, and a review of the meeting transcripts made from audio recordings. Fifteen recommendations were developed for study design and conduct, subject enrollment, outcomes, and measurement instruments. Consensus recommendations included obtaining input from ICU survivors and/or their families, ensuring adequate training for personnel using validated instruments for assessments of sedation, pain, and delirium in the ICU environment, and the need for methodological standardization.ConclusionsThese recommendations are intended to assist researchers in the design, conduct, selection of endpoints, and reporting of clinical trials involving sedative medications and/or sedation protocols for adult ICU patients who require mechanical ventilation. These recommendations should be viewed as a starting point to improve clinical trials and help reduce methodological heterogeneity in future clinical trials.

Published
2021

6. Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: a systematic review and network meta-analysis of randomised trials

Author

Sharif, Sameer, Kang, Jasmine, Sadeghirad, Behnam, Rizvi, Fayyaz, Forestell, Ben, Greer, Alisha, Hewitt, Mark, Fernando, Shannon M., Mehta, Sangeeta, Eltorki, Mohamed, Siemieniuk, Reed, Duffett, Mark, Bhatt, Maala, Burry, Lisa, Perry, Jeffrey J., Petrosoniak, Andrew, Pandharipande, Pratik, Welsford, Michelle, and Rochwerg, Bram

Published
2024
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14. Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials

Author

Lewis, Kimberley, Alshamsi, Fayez, Carayannopoulos, Kallirroi Laiya, Granholm, Anders, Piticaru, Joshua, Al Duhailib, Zainab, Chaudhuri, Dipayan, Spatafora, Laura, Yuan, Yuhong, Centofanti, John, Spence, Jessica, Rochwerg, Bram, Perri, Dan, Needham, Dale M., Holbrook, Anne, Devlin, John W., Nishida, Osamu, Honarmand, Kimia, Ergan, Begüm, Khorochkov, Eugenia, Pandharipande, Pratik, Alshahrani, Mohammed, Karachi, Tim, Soth, Mark, Shehabi, Yahya, Møller, Morten Hylander, and Alhazzani, Waleed

Published
2022
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15. Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline

Author

Møller, Morten H., Alhazzani, Waleed, Lewis, Kimberley, Belley-Cote, Emilie, Granholm, Anders, Centofanti, John, McIntyre, William B., Spence, Jessica, Al Duhailib, Zainab, Needham, Dale M., Evans, Laura, Reintam Blaser, Annika, Pisani, Margaret A., D’Aragon, Frederick, Shankar-Hari, Manu, Alshahrani, Mohammed, Citerio, Giuseppe, Arora, Rakesh C., Mehta, Sangeeta, Girard, Timothy D., Ranzani, Otavio T., Hammond, Naomi, Devlin, John W., Shehabi, Yahya, Pandharipande, Pratik, and Ostermann, Marlies

Published
2022
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17. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness

Author

Girard, Timothy D, Exline, Matthew C, Carson, Shannon S, Hough, Catherine L, Rock, Peter, Gong, Michelle N, Douglas, Ivor S, Malhotra, Atul, Owens, Robert L, Feinstein, Daniel J, Khan, Babar, Pisani, Margaret A, Hyzy, Robert C, Schmidt, Gregory A, Schweickert, William D, Hite, R Duncan, Bowton, David L, Masica, Andrew L, Thompson, Jennifer L, Chandrasekhar, Rameela, Pun, Brenda T, Strength, Cayce, Boehm, Leanne M, Jackson, James C, Pandharipande, Pratik P, Brummel, Nathan E, Hughes, Christopher G, Patel, Mayur B, Stollings, Joanna L, Bernard, Gordon R, Dittus, Robert S, and Ely, E Wesley

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, Mental Health, Acquired Cognitive Impairment, Brain Disorders, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Antipsychotic Agents, Critical Illness, Delirium, Dopamine Antagonists, Double-Blind Method, Female, Haloperidol, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Piperazines, Respiratory Insufficiency, Shock, Thiazoles, Treatment Failure, MIND-USA Investigators, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThere are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU).MethodsIn a randomized, double-blind, placebo-controlled trial, we assigned patients with acute respiratory failure or shock and hypoactive or hyperactive delirium to receive intravenous boluses of haloperidol (maximum dose, 20 mg daily), ziprasidone (maximum dose, 40 mg daily), or placebo. The volume and dose of a trial drug or placebo was halved or doubled at 12-hour intervals on the basis of the presence or absence of delirium, as detected with the use of the Confusion Assessment Method for the ICU, and of side effects of the intervention. The primary end point was the number of days alive without delirium or coma during the 14-day intervention period. Secondary end points included 30-day and 90-day survival, time to freedom from mechanical ventilation, and time to ICU and hospital discharge. Safety end points included extrapyramidal symptoms and excessive sedation.ResultsWritten informed consent was obtained from 1183 patients or their authorized representatives. Delirium developed in 566 patients (48%), of whom 89% had hypoactive delirium and 11% had hyperactive delirium. Of the 566 patients, 184 were randomly assigned to receive placebo, 192 to receive haloperidol, and 190 to receive ziprasidone. The median duration of exposure to a trial drug or placebo was 4 days (interquartile range, 3 to 7). The median number of days alive without delirium or coma was 8.5 (95% confidence interval [CI], 5.6 to 9.9) in the placebo group, 7.9 (95% CI, 4.4 to 9.6) in the haloperidol group, and 8.7 (95% CI, 5.9 to 10.0) in the ziprasidone group (P=0.26 for overall effect across trial groups). The use of haloperidol or ziprasidone, as compared with placebo, had no significant effect on the primary end point (odds ratios, 0.88 [95% CI, 0.64 to 1.21] and 1.04 [95% CI, 0.73 to 1.48], respectively). There were no significant between-group differences with respect to the secondary end points or the frequency of extrapyramidal symptoms.ConclusionsThe use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirium. (Funded by the National Institutes of Health and the VA Geriatric Research Education and Clinical Center; MIND-USA ClinicalTrials.gov number, NCT01211522 .).

Published
2018

18. Executive Summary

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Subjects
Biomedical and Clinical Sciences, Nursing, Clinical Sciences, Health Sciences, Adult, Conscious Sedation, Critical Care, Deep Sedation, Delirium, Humans, Intensive Care Units, Pain, Pain Management, Psychomotor Agitation, Restraint, Physical, Sleep Wake Disorders, delirium, guidelines, intensive care, mobilization, pain, sedation, sleep, Public Health and Health Services, Emergency & Critical Care Medicine, Clinical sciences
Published
2018

19. Executive Summary: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Subjects
Humans, Psychomotor Agitation, Delirium, Pain, Restraint, Physical, Critical Care, Conscious Sedation, Adult, Intensive Care Units, Deep Sedation, Pain Management, Sleep Wake Disorders, delirium, guidelines, intensive care, mobilization, pain, sedation, sleep, Emergency & Critical Care Medicine, Clinical Sciences, Nursing, Public Health and Health Services
Published
2018

20. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Subjects
Humans, Psychomotor Agitation, Delirium, Pain, Restraint, Physical, Critical Care, Conscious Sedation, Intensive Care Units, Deep Sedation, Pain Management, Sleep Wake Disorders, delirium, guidelines, immobility, intensive care, mobilization, pain, sedation, sleep, Restraint, Physical, Emergency & Critical Care Medicine, Clinical Sciences, Nursing, Public Health and Health Services
Abstract

OBJECTIVE:To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU. DESIGN:Thirty-two international experts, four methodologists, and four critical illness survivors met virtually at least monthly. All section groups gathered face-to-face at annual Society of Critical Care Medicine congresses; virtual connections included those unable to attend. A formal conflict of interest policy was developed a priori and enforced throughout the process. Teleconferences and electronic discussions among subgroups and whole panel were part of the guidelines' development. A general content review was completed face-to-face by all panel members in January 2017. METHODS:Content experts, methodologists, and ICU survivors were represented in each of the five sections of the guidelines: Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption). Each section created Population, Intervention, Comparison, and Outcome, and nonactionable, descriptive questions based on perceived clinical relevance. The guideline group then voted their ranking, and patients prioritized their importance. For each Population, Intervention, Comparison, and Outcome question, sections searched the best available evidence, determined its quality, and formulated recommendations as "strong," "conditional," or "good" practice statements based on Grading of Recommendations Assessment, Development and Evaluation principles. In addition, evidence gaps and clinical caveats were explicitly identified. RESULTS:The Pain, Agitation/Sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) panel issued 37 recommendations (three strong and 34 conditional), two good practice statements, and 32 ungraded, nonactionable statements. Three questions from the patient-centered prioritized question list remained without recommendation. CONCLUSIONS:We found substantial agreement among a large, interdisciplinary cohort of international experts regarding evidence supporting recommendations, and the remaining literature gaps in the assessment, prevention, and treatment of Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) in critically ill adults. Highlighting this evidence and the research needs will improve Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) management and provide the foundation for improved outcomes and science in this vulnerable population.

Published
2018

22. Delirium in critical illness: clinical manifestations, outcomes, and management

Author

Stollings, Joanna L., Kotfis, Katarzyna, Chanques, Gerald, Pun, Brenda T., Pandharipande, Pratik P., and Ely, E. Wesley

Subjects
Delirium, Hospital patients, Company business management, Health care industry, Vanderbilt University. Medical Center -- Management
Abstract

Delirium is the most common manifestation of brain dysfunction in critically ill patients. In the intensive care unit (ICU), duration of delirium is independently predictive of excess death, length of stay, cost of care, and acquired dementia. There are numerous neurotransmitter/functional and/or injury-causing hypotheses rather than a unifying mechanism for delirium. Without using a validated delirium instrument, delirium can be misdiagnosed (under, but also overdiagnosed and trivialized), supporting the recommendation to use a monitoring instrument routinely. The best-validated ICU bedside instruments are CAM-ICU and ICDSC, both of which also detect subsyndromal delirium. Both tools have some inherent limitations in the neurologically injured patients, yet still provide valuable information about delirium once the sequelae of the primary injury settle into a new post-injury baseline. Now it is known that antipsychotics and other psychoactive medications do not reliably improve brain function in critically ill delirious patients. ICU teams should systematically screen for predisposing and precipitating factors. These include exacerbations of cardiac/respiratory failure or sepsis, metabolic disturbances (hypoglycemia, dysnatremia, uremia and ammonemia) receipt of psychoactive medications, and sensory deprivation through prolonged immobilization, uncorrected vision and hearing deficits, poor sleep hygiene, and isolation from loved ones so common during COVID-19 pandemic. The ABCDEF (A2F) bundle is a means to facilitate implementation of the 2018 Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PADIS) Guidelines. In over 25,000 patients across nearly 100 institutions, the A2F bundle has been shown in a dose-response fashion (i.e., greater bundle compliance) to yield improved survival, length of stay, coma and delirium duration, cost, and less ICU bounce-backs and discharge to nursing homes., Author(s): Joanna L. Stollings [sup.1] [sup.2], Katarzyna Kotfis [sup.3], Gerald Chanques [sup.4], Brenda T. Pun [sup.1] [sup.5], Pratik P. Pandharipande [sup.1] [sup.5] [sup.6], E. Wesley Ely [sup.1] [sup.5] [sup.7] [sup.8] [...]

Published
2021
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24. DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients

Author

Yamanashi, Takehiko, Saito, Taku, Yu, Tong, Alario, Alexandra, Comp, Katie, Crutchley, Kaitlyn J., Sullivan, Eleanor J., Anderson, Zoe-Ella M., Marra, Pedro S., Chang, Gloria, Wahba, Nadia E., Jellison, Sydney S., Meyer, Alissa A., Mathur, Srishti, Pandharipande, Pratik, Yoshino, Aihide, Kaneko, Koichi, Lee, Sangil, Toda, Hiroyuki, Iwata, Masaaki, and Shinozaki, Gen

Published
2021
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25. The 4-DSD: A New Tool to Assess Delirium Superimposed on Moderate to Severe Dementia

Author

Morandi, Alessandro, Grossi, Eleonora, Lucchi, Elena, Zambon, Antonella, Faraci, Bianca, Severgnini, Jessica, MacLullich, Alasdair, Smith, Heidi, Pandharipande, Pratik, Rizzini, Andrea, Galeazzi, Marianna, Massariello, Francesca, Corradi, Samanta, Raccichini, Alessandra, Scrimieri, Antonia, Morichi, Valeria, Gentile, Simona, Lucchini, Flaminia, Pecorella, Laura, Mossello, Enrico, Cherubini, Antonio, and Bellelli, Giuseppe

Published
2021
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27. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Author

Creteur, Jacques, Bogossian, Elisa Govea, Peluso, Lorenzo, González-Seguel, Felipe, Hidalgo-Calibin, Viviane, Carreño-Montenegro, Pablo, Rojas, Verónica, Tobar, Eduardo, Ramírez-Palma, Antonio, Herrera-Davis, Karen, Ferré, Alexis, Legriel, Stéphane, Godet, Thomas, Fraisse, Ugo, Gonçalves, Bruno, Mazeraud, Aurélien, Tzimou, Myrto, Rasulo, Frank, Beretta, Silvia, Marchesi, Mattia, Robba, Chiara, Battaglini, Denise, Pelosi, Paolo, Mazzeo, Anna Teresa, Noto, Alberto, Servillo, Giuseppe, Marra, Annachiara, Cutuli, Salvatore Lucio, Pintaudi, Gabriele, Stival, Eleonora, Tanzarella, Eloisa Sofia, Roman-Pognuz, Erik, Concetta Massaro, Chiara Maria, Elhadi, Muhammed, Smit, Lisa, Olasveengen, Theresa, Pereira, Isabel Jesus, Teixeira, Carla Margarida, Santos, Alice, Valente, Miguel, Granja, Cristina, Pereia, Rita, Silva, João, Furquet, Blanca, García Simón, Mónica, Godoy Torres, Daniel A, Monleón, Berta, Morcillo, Esteban, Romero, Nekane, Serrano, Ainhoa, Torrico Sánchez, Sara, Pérez Caballero, Francisco Luis, Peña Luna, Isabel, Baeza Gómez, Ignacio, Calizaya Vargas, Milagros, Morillas Pérez, Jordi, Carrasco Gómez, Genís, Molina Latorre, Ricard, Moya Gutiérrez, Sheila, Barón Barrera, Irene Patricia, Delgado Palacios, Cristina, García Góngora, Beatriz, Labrador Romero, Laura, Galarza, Laura, Catalán-Monzón, Ignacio, Rodriguez-Martínez, Enver, Murcia Gubianas, Cristina, Bellès, Ariadna, Rodriguez Delgado, María Esther, Caballero, Jesús, Morales, Dulce, Pujol, Andrés, Rubio, Jorge, Álvarez Torres, Eva, Carvajal Revuelta, Estefanía, de la Calle Gil, Isabel, Fernández Tomás, Blanca, Gallego Rodríguez, Berta, González Serrano, Matilde, LaTorre Andreu, Paloma, Pérez Lucendo, Aris, Abril Palomares, Elena, González González, Elena, Martín Delgado, María Cruz, Muñoz De Cabo, Carlos, Aznar, Pablo T., Calvo, Carlos A., Garutti, Ignacio, Higuero, Fernando, Martínez-Gascueña, David, Maseda, Emilio, Insausti, Itziar, Montero Feijoo, Ana, Suarez-de-la-Rica, Alejandro, Del Moral Barbudo, Beatriz, García Blanco-Traba, Yago, Giménez Santamarina, Maria Claudia, Gonzalo Millán, Alba, Llorente Damas, Sergio, Pestaña Lagunas, David, Reyes García, Isabel, Ruiz Perea, Alejandro, Ortega Guerrero, Álvaro, Mármol Cubillo, María Jesús, Díaz Muñoz, David, García de Castrillón i Ramal, Silvia, Andorrà Sunyer, Xavier, Noci Moreno, María de las Nieves, Pérez Manrique, Rosa María, del Campo Molina, Emilio, Martínez Quintana, María Elena, Fernandez-Gonzalo, Sol, Gomà Fernández, Gemma, Navarra-Ventura, Guillem, Baró Serra, Anna, Fuster, Cristina, Plans Galván, Oriol, Gil-Castillejos, Diana, Dalorzo González, Mario, Morán Gallego, Francisco Javier, Paredes Borrachero, Irene, Rodríguez Villamizar, Patricia, Romeu Prieto, Juan, Sánchez Carretero, María José, Gallardo Sánchez, Susana, Bustos Molina, Filadelfo, García Pérez, María Luisa, Castello-Mora, Paula, Puig, Jaume, Sanchis-Martin, María Rosa, Sanchis-Veryser, Carmen Andrea, Vicente-Fernández, María Pilar, Zaragoza, Rafael, Lizama, Laura, Torres, Irene, Álvarez, Cristina, Ramírez, Paula, Martin Cerezuela, Meri, Montero, María Jesús, García Cantos, Jose, Valls, Paola, Aretxabala Cortajarena, Nerea, García Domelo, Pablo, González Cubillo, Laura, Martín Martínez, Marta, Pérez Francisco, Inés, Poveda Hernández, Yolanda, Quintano Rodero, Amaia, Rodriguez Nuñez, César, Siegemund, Martin, Estermann, Anna, Zellweger, Núria, Ben Saida, Imen, Boussarsar, Mohamed, Esen, Figen, Ergin Özcan, Perihan, Berkey, Christopher, Harb, Christine, Tandy, Morgan H., Morgan, Ellis, Shephard, Karen, Hyzy, Robert C, Kenes, Michael, Nelson, Kristine, Hosse, Robert E., Vance, Katie M., Austin, C. Adrian, Lerner, Aaron, Sanders, Emily, Balk, Robert A, Bennett, David A, Vogel, Andrew R., Chowdhury, Lucia, Devulapally, Kiran, Woodham, Michelle, Cohen, Sarah, Patel, Nihal, Kuza, Catherine M., Sing, Mandeep, Roberson, Spencer, Drumright, Kelly, Sehgal, Sameep, LaHue, Sara C., Douglas, Vanja C., Sarwal, Aarti, Pun, Brenda T, Badenes, Rafael, Heras La Calle, Gabriel, Orun, Onur M, Chen, Wencong, Raman, Rameela, Simpson, Beata-Gabriela K, Wilson-Linville, Stephanie, Hinojal Olmedillo, Borja, Vallejo de la Cueva, Ana, van der Jagt, Mathieu, Navarro Casado, Rosalía, Leal Sanz, Pilar, Orhun, Günseli, Ferrer Gómez, Carolina, Núñez Vázquez, Karla, Piñeiro Otero, Patricia, Taccone, Fabio Silvio, Gallego Curto, Elena, Caricato, Anselmo, Woien, Hilde, Lacave, Guillaume, O'Neal, Hollis R, Jr, Peterson, Sarah J, Brummel, Nathan E, Girard, Timothy D, Ely, E Wesley, and Pandharipande, Pratik P

Published
2021
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28. The Delphi Delirium Management Algorithms: A practical tool for clinicians, the result of a modified Delphi expert consensus approach

Author

AIOS Anesthesiologie, AIOS Psychiatrie, Brain, Ottens, Thomas H, Hermes, Carsten, Page, Valerie, Oldham, Mark, Arora, Rakesh, Bienvenu, O Joseph, van den Boogaard, Mark, Caplan, Gideon, Devlin, John W, Friedrich, Michaela-Elena, van Gool, Willem A, Hanison, James, Hansen, Hans-Christian, Inouye, Sharon K, Kamholz, Barbara, Kotfis, Katarzyna, Maas, Matthew B, MacLullich, Alasdair M J, Marcantonio, Edward R, Morandi, Alessandro, van Munster, Barbara C, Müller-Werdan, Ursula, Negro, Alessandra, Neufeld, Karin J, Nydahl, Peter, Oh, Esther S, Pandharipande, Pratik, Radtke, Finn M, Raedt, Sylvie De, Rosenthal, Lisa J, Sanders, Robert, Spies, Claudia D, Vardy, Emma R L C, Wijdicks, Eelco F, Slooter, Arjen J C, AIOS Anesthesiologie, AIOS Psychiatrie, Brain, Ottens, Thomas H, Hermes, Carsten, Page, Valerie, Oldham, Mark, Arora, Rakesh, Bienvenu, O Joseph, van den Boogaard, Mark, Caplan, Gideon, Devlin, John W, Friedrich, Michaela-Elena, van Gool, Willem A, Hanison, James, Hansen, Hans-Christian, Inouye, Sharon K, Kamholz, Barbara, Kotfis, Katarzyna, Maas, Matthew B, MacLullich, Alasdair M J, Marcantonio, Edward R, Morandi, Alessandro, van Munster, Barbara C, Müller-Werdan, Ursula, Negro, Alessandra, Neufeld, Karin J, Nydahl, Peter, Oh, Esther S, Pandharipande, Pratik, Radtke, Finn M, Raedt, Sylvie De, Rosenthal, Lisa J, Sanders, Robert, Spies, Claudia D, Vardy, Emma R L C, Wijdicks, Eelco F, and Slooter, Arjen J C

Published
2024

29. Advancing specificity in delirium: The delirium subtyping initiative

Author

AIOS Psychiatrie, Brain, Affectieve & Psychotische Med., Bowman, Emily M L, Brummel, Nathan E, Caplan, Gideon A, Cunningham, Colm, Evered, Lis A, Fiest, Kirsten M, Girard, Timothy D, Jackson, Thomas A, LaHue, Sara C, Lindroth, Heidi L, Maclullich, Alasdair M J, McAuley, Daniel F, Oh, Esther S, Oldham, Mark A, Page, Valerie J, Pandharipande, Pratik P, Potter, Kelly M, Sinha, Pratik, Slooter, Arjen J C, Sweeney, Aoife M, Tieges, Zoë, Van Dellen, Edwin, Wilcox, Mary Elizabeth, Zetterberg, Henrik, Cunningham, Emma L, AIOS Psychiatrie, Brain, Affectieve & Psychotische Med., Bowman, Emily M L, Brummel, Nathan E, Caplan, Gideon A, Cunningham, Colm, Evered, Lis A, Fiest, Kirsten M, Girard, Timothy D, Jackson, Thomas A, LaHue, Sara C, Lindroth, Heidi L, Maclullich, Alasdair M J, McAuley, Daniel F, Oh, Esther S, Oldham, Mark A, Page, Valerie J, Pandharipande, Pratik P, Potter, Kelly M, Sinha, Pratik, Slooter, Arjen J C, Sweeney, Aoife M, Tieges, Zoë, Van Dellen, Edwin, Wilcox, Mary Elizabeth, Zetterberg, Henrik, and Cunningham, Emma L

Published
2024

34. Antipsychotics and the QTc Interval During Delirium in the Intensive Care Unit

Author

Stollings, Joanna L., primary, Boncyk, Christina S., additional, Birdrow, Caroline I., additional, Chen, Wencong, additional, Raman, Rameela, additional, Gupta, Deepak K., additional, Roden, Dan M., additional, Rivera, Erika L., additional, Maiga, Amelia W., additional, Rakhit, Shayan, additional, Pandharipande, Pratik P., additional, Ely, E. Wesley, additional, Girard, Timothy D., additional, and Patel, Mayur B., additional

Published
2024
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36. Analgesia and sedation in patients with ARDS

Author

Chanques, Gerald, Constantin, Jean-Michel, Devlin, John W., Ely, E. Wesley, Fraser, Gilles L., Gélinas, Céline, Girard, Timothy D., Guérin, Claude, Jabaudon, Matthieu, Jaber, Samir, Mehta, Sangeeta, Langer, Thomas, Murray, Michael J., Pandharipande, Pratik, Patel, Bhakti, Payen, Jean-François, Puntillo, Kathleen, Rochwerg, Bram, Shehabi, Yahya, Strøm, Thomas, Olsen, Hanne Tanghus, and Kress, John P.

Published
2020
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46. Contributors

Author

Ackland, Gareth L., primary, Ahmed, Adeel Rafi, additional, Annane, Djillali, additional, Ansari, Eman, additional, Axer, Hubertus, additional, Bakker, Jan, additional, Barbash, Ian J., additional, Bates, John James, additional, Bauer, Michael, additional, Bellinghausen, Amy L., additional, Bender, William S., additional, Biery, Matthew R., additional, Binnie, Alexandra, additional, Bleck, Thomas P., additional, Boncyk, Christina, additional, Brainard, Jason C., additional, Brakenridge, Scott C., additional, Brunkhorst, Frank Martin, additional, BSc(Physio), Tara Cahill,, additional, Campbell, Christina, additional, Casey, Jonathan Dale, additional, Cavaillon, Jean-Marc, additional, Cereda, Maurizio, additional, Cooper, David J., additional, Coopersmith, Craig M., additional, Cruz, Jennifer, additional, Cunha, Cheston B., additional, Curley, Gerard F., additional, Dalton, Allison, additional, Backer, Daniel De, additional, Deutschman, Clifford S., additional, Devlin, David, additional, Dos, Claudia C., additional, Drabek, Tomas, additional, Dragoi, Laura, additional, Dres, Martin, additional, Drewry, Anne M., additional, Duff, Stephen, additional, Efron, Philip A., additional, MB, Sinéad Egan,, additional, El, Ali A., additional, Ely, E. Wesley, additional, Evans, Laura, additional, Falco-Walter, Jessica, additional, Frogel, Jonathan K., additional, Ferguson, Niall D., additional, Fernandez-Moure, Joseph S., additional, Furmaga, Jakub, additional, Gaieski, David Foster, additional, Gajic, Ognjen, additional, De, Alice Gallo, additional, Genga, Kelly R., additional, Geoghegan, Pierce, additional, Giamarellos-Bourboulis, Evangelos J., additional, Gill, Rick, additional, Goligher, Ewan C., additional, Gordon, Emily K., additional, Grabenkort, W. Robert, additional, Gupta, Garima, additional, Gutsche, Jacob T., additional, Guven, Goksel, additional, Guyatt, Paige, additional, Heming, Nicholas, additional, Hendrix, Cheralyn J., additional, Hollen, McKenzie K., additional, Hollenberg, Steven M., additional, Tuan Ha, Vivien Hong, additional, Horie, Shahd, additional, Hough, Catherine L., additional, Ince, Can, additional, Iwashyna, Theodore J., additional, Jacobi, Judith, additional, Jeschke, Marc, additional, Johnson, Nicholas J., additional, Kahn, Jeremy M., additional, Kaplan, Lewis J., additional, Keegan, Mark T., additional, Kempker, Jordan Anthony, additional, Kevin, Leo G., additional, Khan, Yasin A., additional, Kleinpell, Ruth, additional, Kleinschmidt, Kurt, additional, Klompas, Michael, additional, Kochanek, Patrick M., additional, Kofke, W. Andrew, additional, Kohl, Benjamin, additional, Kortgen, Andreas, additional, Kung, David, additional, Laffey, John G., additional, Lage, Joel, additional, Lappin, David William, additional, Lamontagne, Francois, additional, Leisman, Daniel E., additional, Leong, Ron, additional, Levine, Joshua M., additional, Levinson, Andrew T., additional, Levy, Mitchell M., additional, Lewis, Ariane, additional, Slavin, Ariel Tamara, additional, Lheureux, Olivier, additional, Liu, Vincent X., additional, Lyons, Craig, additional, Maley, Jason H., additional, Malhotra, Atul, additional, Marks, Joshua A., additional, Martin, Greg S., additional, Martin, Niels D., additional, Masterson, Claire, additional, Mayasi, Yunis, additional, Maxime, Virginie, additional, McNicholas, Bairbre Aine, additional, McSparron, Jakob, additional, Meade, Maureen O., additional, Mikkelsen, Mark E., additional, Mohr, Alicia M., additional, Moran, Peter, additional, Moss, Stephanie Royer, additional, Murray, Patrick T., additional, Neligan, Patrick J., additional, Nguyen, Larry X., additional, Nichol, Alistair D., additional, Nugent, Katherine Lyn, additional, Nunnally, Mark E., additional, O’Connor, Michael F., additional, Odeyemi, Yewande, additional, Opal, Steven M., additional, O’Regan, Anthony, additional, O’Regan, John, additional, O’Shaughnessy, Michelle, additional, Owens, Robert L., additional, Pandharipande, Pratik, additional, Peltan, Ithan D., additional, Perner, Anders, additional, Pinsky, Michael R., additional, Piper, Greta, additional, Plante, Lauren A., additional, Pratzer, Ariella, additional, Preiser, Jean-Charles, additional, Prescott, Hallie C., additional, Quintana, Megan T., additional, Raab, Lindsay, additional, Radowsky, Jason S., additional, Raiten, Jesse M., additional, G. Reidy, Bryan T., additional, Reilly, Patrick M., additional, Remy, Kenneth E., additional, Rezoagli, Emanuele, additional, Ricci, Zaccaria, additional, Rivas, Lisbi, additional, Rochwerg, Bram, additional, Rock, Kristen Carey, additional, Ronco, Claudio, additional, Russell, James A., additional, Sandsmark, Danielle K., additional, Santos, Joshua Iokepa, additional, Sarani, Babak, additional, Scales, Damon C., additional, Scully, Michael, additional, Sevransky, Jon, additional, Shemie, Sam D., additional, Sims, Carrie A., additional, Smith, Brian P., additional, Spelde, Audrey E., additional, Stevens, Robert David, additional, Thompson, B. Taylor, additional, Tisherman, Samuel A., additional, Trinder, Mark, additional, Turnbull, Isaiah R., additional, MBBS, Ida-Fong Ukor,, additional, der Poll, Tom van, additional, van Engelen, Tjitske S.R., additional, Vasquez, Charles R., additional, Vella, Michael A., additional, Vernick, William J., additional, Villa, Gianluca, additional, Vincent, Jean-Louis, additional, Walker, Amy C., additional, Walley, Keith R., additional, Ware, Lorraine B., additional, Weiss, Stuart J., additional, Garcia, Anna E., additional, and Whyte, Pauline, additional

Published
2020
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