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27 results on '"Pandey, Aruna"'

8. Expression kinetics of ISG15, IRF3, IFNγ, IL10, IL2 and IL4 genes vis-a-vis virus shedding, tissue tropism and antibody dynamics in PPRV vaccinated, challenged, infected sheep and goats

Author

Wani, Sajad Ahmad, Sahu, Amit Ranjan, Saxena, Shikha, Rajak, Kaushal Kishor, Saminathan, M., Sahoo, Aditya Prasad, Kanchan, Sonam, Pandey, Aruna, Mishra, Bina, Muthuchelvan, D., Tiwari, Ashok Kumar, Mishra, Bishnu Prasad, Singh, Raj Kumar, and Gandham, Ravi Kumar

Published
2018
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10. Comparative and temporal transcriptome analysis of peste des petits ruminants virus infected goat peripheral blood mononuclear cells

Author

Manjunath, Siddappa, Mishra, Bishnu Prasad, Mishra, Bina, Sahoo, Aditya Prasad, Tiwari, Ashok K., Rajak, Kaushal Kishore, Muthuchelvan, D., Saxena, Shikha, Santra, Lakshman, Sahu, Amit Ranjan, Wani, Sajad Ahmad, Singh, R.P., Singh, Y.P., Pandey, Aruna, Kanchan, Sonam, Singh, R.K., Kumar, Gandham Ravi, and Janga, Sarath Chandra

Published
2017
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12. Genome sequencing of an Indian peste des petits ruminants virus isolate, Izatnagar/94, and its implications for virus diversity, divergence and phylogeography

Author

Sahu, Amit Ranjan, Wani, Sajad Ahmad, Saminathan, M., Rajak, Kaushal Kishor, Sahoo, Aditya Prasad, Pandey, Aruna, Saxena, Shikha, Kanchan, Sonam, Tiwari, Ashok Kumar, Mishra, Bina, Muthuchelvan, D., Singh, R. P., Singh, Yaspal, Baig, Mumtaz, Mishra, Bishnu Prasad, Singh, Raj Kumar, and Gandham, Ravi Kumar

Published
2017
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13. Selection and validation of suitable reference genes for qPCR gene expression analysis in goats and sheep under Peste des petits ruminants virus (PPRV), lineage IV infection

Author

Sahu, Amit Ranjan, Wani, Sajad Ahmad, Saxena, Shikha, Rajak, Kaushal Kishor, Chaudhary, Dheeraj, Sahoo, Aditya Prasad, Khanduri, Alok, Pandey, Aruna, Mondal, Piyali, Malla, Waseem Akram, Khan, Raja Ishaq Nabi, Tiwari, Ashok Kumar, Mishra, Bina, Muthuchelvan, D., Mishra, Bishnu Prasad, Singh, Raj Kumar, and Gandham, Ravi Kumar

Published
2018
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14. Differential expression of long non-coding RNAs under Peste des petits ruminants virus (PPRV) infection in goats

Author

Pandey, Aruna, primary, Malla, Waseem Akram, additional, Sahu, Amit Ranjan, additional, Wani, Sajad Ahmad, additional, Khan, Raja Ishaq Nabi, additional, Saxena, Shikha, additional, Ramteke, P. W., additional, Praharaj, Manas Ranjan, additional, Kumar, Amit, additional, Rajak, Kaushal Kishor, additional, Mishra, Bina, additional, Muthuchelvan, D., additional, Sajjanar, Basavaraj, additional, Mishra, Bishnu Prasad, additional, Singh, Raj Kumar, additional, and Gandham, Ravi Kumar, additional

Published
2022
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17. Systems biology under heat stress in Indian cattle

Author

Khan, Raja Ishaq Nabi, primary, Sahu, Amit Ranjan, additional, Malla, Waseem Akram, additional, Praharaj, Manas Ranjan, additional, Hosamani, Neelima, additional, Kumar, Shakti, additional, Gupta, Smita, additional, Sharma, Shweta, additional, Saxena, Archana, additional, Varshney, Anshul, additional, Singh, Pragya, additional, Verma, Vinay, additional, Kumar, Puneet, additional, Singh, Gyanendra, additional, Pandey, Aruna, additional, Saxena, Shikha, additional, Gandham, Ravi Kumar, additional, and Tiwari, Ashok Kumar, additional

Published
2021
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18. HSPs, Ubiquitins and Antioxidants aid in Heat Tolerance in Tharparkar Indicine cattle

Author

Khan, Raja Ishaq Nabi, Sahu, Amit Ranjan, Malla, Waseem Akram, Praharaj, Manas Ranjan, Hosamani, Neelima, Kumar, Shakti, Gupta, Smita, Sharma, Shweta, Saxena, Archana, Varshney, Anshul, Singh, Pragya, Verma, Vinay, Kumar, Puneet, Singh, Gyanendra, Pandey, Aruna, Saxena, Shikha, Gandham, Ravi Kumar, and Tiwari, Ashok Kumar

Abstract

Background Heat stress induced by high environmental temperature and humidity affects livestock production and health. With global warming on the uprise, indigenous cattle known for their heat tolerance are gaining importance than the crossbreds. However, systems biology behind this phenotype in indigenous cattle is less known. In this study using transcriptome analysis, we identified key molecules and pathways that may lead to the heat tolerance phenotype in indigenous cattle (Tharparkar breed) Results The number of DEGs in Crossbred were found to be more than in Tharparkar suggesting a greater dysregulation in systems biology in Crossbred. A contrast in gene expression was observed with 18.5 % of upregulated genes in Crossbred (Vrindavani cattle) downregulated in Tharparkar and 17.5% upregulated genes in Tharparkar downregulated in Crossbred. The increased HSPs levels have been found positively correlated with tolerance in many species. Upregulation of HSF, HSP70, HSP90 , and activation of eIF2 signaling pathway in Tharparkar and vice-versa in Crossbred delineates how Tharparkar withstands heat stress. Unlike Crossbred, Tharparkar is not only endowed with higher expression of the scavengers ( UBE2G1, UBE2S , and UBE2H ) of misfolded proteins but also with protectors ( VCP, Serp1 , and CALR ) of naïve unfolded proteins. Further, the apoptotic genes that were dysregulated in both genetic groups indicated a relatively higher probability of apoptosis in Crossbred than in Tharparkar. Also, higher expression of the antioxidants in Tharparkar enables it to cope up with higher levels of free radicals generated as a result of heat stress. Conclusion In this study we found relevant molecules/genes dysregulated in Tharparkar in the direction that can counter heat stress. To best of our knowledge this is a comprehensive comparison between Tharparkar and crossbred at a global level using transcriptome analysis.

Published
2020
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19. Differential expression of long non-coding RNAs under Peste des petits ruminants virus(PPRV) infection in goats

Author

Pandey, Aruna, Malla, Waseem Akram, Sahu, Amit Ranjan, Wani, Sajad Ahmad, Khan, Raja Ishaq Nabi, Saxena, Shikha, Ramteke, P. W., Praharaj, Manas Ranjan, Kumar, Amit, Rajak, Kaushal Kishor, Mishra, Bina, Muthuchelvan, D., Sajjanar, Basavaraj, Mishra, Bishnu Prasad, Singh, Raj Kumar, and Gandham, Ravi Kumar

Abstract

ABSTRACTPeste des petits ruminants(PPR) characterized by fever, sore mouth, conjunctivitis, gastroenteritis, and pneumonia, is an acute, highly contagious viral disease of sheep and goats. The role of long non-coding RNAs (lncRNAs) in PPRV infection has not been explored to date. In this study, the transcriptome profiles of virulent Peste des petits ruminants virus (PPRV) infected goat tissues – lung and spleen were analyzed to identify the role of lncRNAs in PPRV infection. A total of 13,928 lncRNA transcripts were identified, out of which 170 were known lncRNAs. Intergenic lncRNAs (7625) formed the major chunk of the novel lncRNA transcripts. Differential expression analysis revealed that 15 lncRNAs (11 downregulated and 4 upregulated) in the PPRV infected spleen samples and 16 lncRNAs (13 downregulated and 3 upregulated) in PPRV infected lung samples were differentially expressed as compared to control. The differentially expressed lncRNAs (DElncRNAs) possibly regulate various immunological processes related to natural killer cell activation, antigen processing and presentation, and B cell activity, by regulating the expression of mRNAs through the cis- or trans-regulatory mechanism. Functional enrichment analysis of differentially expressed mRNAs (DEmRNAs) revealed enrichment of immune pathways and biological processes in concordance with the pathways in which correlated lncRNA-neighboring genes were enriched. The results suggest that a coordinated immune response is raised in both lung and spleen tissues of the goat through mRNA-lncRNA crosstalk.

Published
2022
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21. Systems Biology under heat stress in Indian Cattle

Author

Khan, Raja Ishaq Nabi, primary, Sahu, Amit Ranjan, additional, Malla, Waseem Akram, additional, Praharaj, Manas Ranjan, additional, Hosamani, Neelima, additional, Kumar, Shakti, additional, Gupta, Smita, additional, Sharma, Shweta, additional, Saxena, Archana, additional, Varshney, Anshul, additional, Singh, Pragya, additional, Verma, Vinay, additional, Kumar, Puneet, additional, Singh, Gyanendra, additional, Pandey, Aruna, additional, Saxena, Shikha, additional, Gandham, Ravi Kumar, additional, and Tiwari, Ashok Kumar, additional

Published
2020
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22. Signature of genome wide gene expression in classical swine fever virus infected macrophages and PBMCs of indigenous vis-a-vis crossbred pigs

Author

Sah, Vaishali, primary, Kumar, Amit, additional, Dhar, P., additional, Upmanyu, V., additional, Tiwari, A.K., additional, Wani, Sajad A., additional, Sahu, A.R., additional, Kumar, Ajay, additional, Badasara, S.K., additional, Pandey, Aruna, additional, Saxena, Shikha, additional, Rai, Anil, additional, Mishra, B.P., additional, Singh, R.K., additional, and Gandham, Ravi Kumar, additional

Published
2020
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23. Contrasting Gene Expression Profiles of Monocytes and Lymphocytes From Peste-Des-Petits-Ruminants Virus Infected Goats

Author

Wani, Sajad Ahmad, primary, Sahu, Amit Ranjan, additional, Khan, Raja Ishaq Nabi, additional, Pandey, Aruna, additional, Saxena, Shikha, additional, Hosamani, Neelima, additional, Malla, Waseem Akram, additional, Chaudhary, Dheeraj, additional, Kanchan, Sonam, additional, Sah, Vaishali, additional, Rajak, Kaushal Kishor, additional, Muthuchelvan, D., additional, Mishra, Bina, additional, Tiwari, Ashok Kumar, additional, Sahoo, Aditya P., additional, Sajjanar, Basavaraj, additional, Singh, Yash Pal, additional, Gandham, Ravi Kumar, additional, Mishra, Bishnu Prasad, additional, and Singh, Raj Kumar, additional

Published
2019
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24. Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response

Author

Khanduri, Alok, primary, Sahu, Amit Ranjan, additional, Wani, Sajad Ahmad, additional, Khan, Raja Ishaq Nabi, additional, Pandey, Aruna, additional, Saxena, Shikha, additional, Malla, Waseem Akram, additional, Mondal, Piyali, additional, Rajak, Kaushal Kishor, additional, Muthuchelvan, D., additional, Mishra, Bina, additional, Sahoo, Aditya P., additional, Singh, Yash Pal, additional, Singh, Raj Kumar, additional, Gandham, Ravi Kumar, additional, and Mishra, Bishnu Prasad, additional

Published
2018
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27. Draft genome sequence of field isolate Brucella melitensisstrain 2007BM/1 from India

Author

Singh, D.K., Kumar, Bablu, Shrinet, Garima, Singh, R.P., Das, Aparajita, Mantur, B.G., Abhishek, Pandey, Aruna, Mondal, Piyali, Sajjanar, B.K., Doimari, Soni, Singh, Vijayata, Kumari, Reena, Tiwari, A.K., and Gandham, Ravi kumar

Abstract

Brucellosis is among one of the most widespread important global zoonotic diseases that is endemic in many parts of India. Brucella melitensisis supposed to be the most pathogenic species for humans. Here we report the draft genome sequence of B. melitensisstrain 2007BM/1 isolated from a human in India.

Published
2018
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