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119 results on '"Pande, Rupaly"'

1. Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN): Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy

Author

Lucocq, James, Haugk, Beate, Parkinson, Daniel, Darne, Antony, Joseph, Nejo, Hawkyard, Jake, White, Steve, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V. M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Deborah, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Roberts, Keith, Soreide, Kjetil, Gill, Anthony J., and Pandanaboyana, Sanjay

Published
2024
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2. ASO Visual Abstract: Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN)—Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy

Author

Lucocq, James, Haugk, Beate, Parkinson, Daniel, Darne, Antony, Joseph, Nejo, Hawkyard, Jake, White, Steve, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V. M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Deborah, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Roberts, Keith, Soreide, Kjetil, Gill, Anthony J., and Pandanaboyana, Sanjay

Published
2024
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3. Invasive intraductal oncocytic papillary neoplasms (IOPN) and adenocarcimoma arising from intraductal papillary mucinous neoplasms (A-IPMN) of the pancreas: comparative analysis of clinicopathological features, patterns of recurrence and survival: a multicentre study

Author

Lucocq, James, Haugk, Beate, Joseph, Nejo, Hawkyard, Jake, White, Steve, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V.M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Zaharia, Claudia, Ciprani, Debora, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Roberts, Keith, Soreide, Kjetil, Gill, Anthony J., and Pandanaboyana, Sanjay

Published
2024
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4. Predictors of long-term survival after resection of adenocarcinoma arising from intraductal papillary mucinous neoplasm and derivation of a prognostic model: An international multicenter study (ADENO-IPMN study)

Author

Lucocq, James, Joseph, Nejo, Hawkyard, Jake, Haugk, Beate, White, Steve, Lye, Jonathan, Parkinson, Daniel, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Hirose, Yuki, Sasahira, Naoki, Inoue, Yosuke, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby, Roberts, Keith, Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Marks, Kate, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Debora, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Stättner, Stefan, Bellotti, Ruben, Alsaoudi, Tareq, Bhardwaj, Neil, Rajesh, Srujan, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Gill, Anthony, Soreide, Kjetil, and Pandanaboyana, Sanjay

Published
2024
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5. Risk of Recurrence After Surgical Resection for Adenocarcinoma Arising From Intraductal Papillary Mucinous Neoplasia (IPMN) With Patterns of Distribution and Treatment: An International, Multicenter, Observational Study (ADENO-IPMN Study)

Author

Lucocq, James, Hawkyard, Jake, Robertson, Francis P., Haugk, Beate, Lye, Jonathan, Parkinson, Daniel, White, Steve, Mownah, Omar, Zen, Yoh, Menon, Krishna, Furukawa, Takaaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Feretis, Michael, Balakrishnan, Anita, Zelga, Piotr, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby, Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Debora, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Sheen, Amy, Mittal, Anubhav, Samra, Jas, Gill, Anthony, Roberts, Keith, Soreide, Kjetil, and Pandanaboyana, Sanjay

Published
2024
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6. Long-term Outcomes following Resection of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) versus Pancreatic Ductal Adenocarcinoma (PDAC): A Propensity-score Matched Analysis

Author

Lucocq, James, Halle-Smith, James, Haugk, Beate, Joseph, Nejo, Hawkyard, Jake, Lye, Jonathan, Parkinson, Daniel, White, Steve, Mownah, Omar, Zen, Yoh, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V.M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Marks, Kate, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Debora, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Rajesh, Srujan, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Soreide, Kjetil, Gill, Anthony J., Roberts, Keith, and Pandanaboyana, Sanjay

Published
2024
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7. Five-year recurrence/survival after pancreatoduodenectomy for pancreatic adenocarcinoma: does pre-existing diabetes matter? Results from the Recurrence After Whipple's (RAW) study

Author

Lead Unit, Aroori, Somaiah, Labib, Peter L., Russell, Thomas B., Streeter, Adam, Denson, Jemimah, Puckett, Mark, Zhou, Shang-Ming, Browning, Matthew, Collaborating Units, Ausania, Fabio, Gonzalez-Abos, Carolina, Pando, Elizabeth, Fernandes, Nair, Moller, Elsa G., Taboada, Cristina D., Roberts, Keith, Pande, Rupaly, Alfarah, Jameel, Kausar, Ambareen, Bandyopadhyay, Samik, Abdelrahim, Ahmed, Khan, Ayesha, Mavroeidis, Vasileios K., Jordan, Caitlin, Rees, Jonathan R.E., Marangoni, Gabriele, Blege, Harry, Thomasset, Sarah, Cambridge, William, White, Olga, Frampton, Adam, Blacker, Sarah, Blackburn, Jessie, Sweeney, Casie, Lykoudis, Pavlos, Field, Daniel, Gouda, Mohammed, Maglione, Manuel, Bellotti, Ruben, Alhaboob, Nassir, Hamid, Hytham K.S., Bari, Hassaan, Ahmed, Hassan, Smith, Andrew, Moriarty, Catherine, White, Louise, Priestley, Mark, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Craven, Samuel, Spalding, Duncan, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Onifade, Anjola, Srinivasan, Parthi, Ribaud, Julliette, Nair, Ashitha, Mariathasan, Michael, Grayson, Niamh, Davidson, Brian, Pericleous, Stephanos, Patel, Krishna, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad K., Bhogal, Ricky, Doyle, Joseph, Croagh, Daniel, Rajagopalan, Ashray, Dominguez, Ismael, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Thakkar, Rohan, Jones, Michael, Buckley, Edward, Akter, Nasreen, Treherne, Kyle, Gomez, Dhanny, Gordon, Gregory, Silva, Michael, Hughes, Daniel, Urbonas, Tomas, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Caronna, Roberto, Chirletti, Piero, Porcu, Alberto, Perra, Teresa, Shah, Nehal S., Abd Kahar, Nurul N., Hall, Thomas, Nadeem, Nabeegh, Hamady, Zaed, Karar, Shoura, Arshad, Ali, Al-Sarrieh, Bilal, Yarwood, Adam, Hammoda, Mohammed, Serrablo, Alejandro, Artigas, Maria, Paterna-López, Sandra, Roberts, Keith J., Thomasset, Sarah C., Frampton, Adam E., Smith, Andrew M., Davidson, Brian R., Bhogal, Ricky H., Silva, Michael A., and Hamady, Zaed Z.R.

Published
2024
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8. Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for distal cholangiocarcinoma: An international multicentre retrospective cohort study

Author

Browning, Matthew, Mownah, Omar, Gonzalez-Abos, Carolina, Fernandes, Nair, Moller, Elsa Garcia, Taboada, Cristina Dopazo, Pande, Rupaly, Alfarah, Jameel, Bandyopadhyay, Samik, Abdelrahim, Ahmed, Khan, Ayesha, Jordan, Caitlin, Rees, Jonathan RE., Doyle, Joseph, Blege, Harry, Cambridge, William, White, Olga, Blacker, Sarah, Blackburn, Jessie, Sweeney, Casie, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Onifade, Anjola, Field, Daniel, Gouda, Mohammed, Maglione, Manuel, Hamid, Hytham KS., Ribaud, Julliette, Nair, Ashitha, Mariathasan, Michael, Grayson, Niamh, Ahmed, Hassan, Moriarty, Catherine, White, Louise, Priestley, Mark, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Craven, Samuel, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Jones, Michael, Buckley, Edward, Akter, Nasreen, Treherne, Kyle, Gordon, Gregory, Hughes, Daniel, Urbonas, Tomas, Brachini, Gioia, Caronna, Roberto, Chirletti, Piero, Pericleous, Stephanos, Patel, Krishna, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad K., Perra, Teresa, Abd Kahar, Nurul Nadhirah, Hall, Thomas, Nadeem, Nabeegh, Karar, Shoura, Arshad, Ali, Yarwood, Adam, Hammoda, Mohammed, Artigas, Maria Consuelo, Paterna-López, Sandra, Labib, Peter LZ., Russell, Thomas B., Denson, Jemimah L., Puckett, Mark A., Ausania, Fabio, Pando, Elizabeth, Roberts, Keith J., Kausar, Ambareen, Mavroeidis, Vasileios K., Bhogal, Ricky H., Marangoni, Gabriele, Thomasset, Sarah C., Frampton, Adam E., Spalding, Duncan R., Lykoudis, Pavlos, Bellotti, Ruben, Alhaboob, Nassir, Srinivasan, Parthi, Bari, Hassaan, Smith, Andrew, Dominguez-Rosado, Ismael, Croagh, Daniel, Thakkar, Rohan G., Gomez, Dhanny, Silva, Michael A., Lapolla, Pierfrancesco, Mingoli, Andrea, Davidson, Brian R., Porcu, Alberto, Shah, Nehal S., Hamady, Zaed Z., Al-Sarireh, Bilal A., Serrablo, Alejandro, and Aroori, Somaiah

Published
2024
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10. Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Results from the recurrence after Whipple's (RAW) study

Author

Labib, Peter L., Russell, Thomas B., Streeter, Adam, Denson, Jemimah, Puckett, Mark, Zhou, Shang-Ming, Browning, Matthew, Aroori, Somaiah, Ausania, Fabio, Pando, Elizabeth, Roberts, Keith, Kausar, Ambareen, Mavroeidis, Vasileios K., Marangoni, Gabriele, Thomasset, Sarah, Frampton, Adam, Lykoudis, Pavlos, Maglione, Manuel, Alhaboob, Nassir, Bari, Hassaan, Smith, Andrew, Spalding, Duncan, Srinivasan, Parthi, Davidson, Brian, Bhogal, Ricky, Croagh, Daniel, Dominguez, Ismael, Thakkar, Rohan, Gomez, Dhanny, Silva, Michael, Lapolla, Pierfrancesco, Mingoli, Andrea, Porcu, Alberto, Shah, Nehal Sureshkumar, Hamady, Zaed, Al-Sarrieh, Bilal, Serrablo, Alejandro, Gonzalez-Abos, Carolina, Fernandes, Nair, Moller, Elsa Garcia, Taboada, Cristina Dopazo, Pande, Rupaly, Alfarah, Jameel, Bandyopadhyay, Samik, Abdelrahim, Ahmed, Khan, Ayesha, Jordan, Caitlin, Rees, Jonathan R.E., Blege, Harry, Cambridge, William, White, Olga, Blacker, Sarah, Blackburn, Jessie, Sweeney, Casie, Field, Daniel, Gouda, Mohammed, Bellotti, Ruben, Hamid, Hytham K.S., Ahmed, Hassan, Moriarty, Catherine, White, Louise, Priestley, Mark, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Craven, Samuel, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Onifade, Anjola, Ribaud, Julliette, Nair, Ashitha, Mariathasan, Michael, Grayson, Niamh, Pericleous, Stephanos, Patel, Krishna, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad Khish, Doyle, Joseph, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Jones, Michael, Buckley, Edward, Akter, Nasreen, Treherne, Kyle, Gordon, Gregory, Hughes, Daniel, Urbonas, Tomas, Brachini, Gioia, Caronna, Roberto, Chirletti, Piero, Perra, Teresa, Abd Kahar, Nurul Nadhirah, Hall, Thomas, Nadeem, Nabeegh, Karar, Shoura, Arshad, Ali, Yarwood, Adam, Hammoda, Mohammed, Artigas, Maria, Paterna-López, Sandra, Roberts, Keith J., Thomasset, Sarah C., Frampton, Adam E., Smith, Andrew M., Davidson, Brian R., Bhogal, Ricky H., Silva, Michael A., Shah, Nehal S., and Hamady, Zaed Z.R.

Published
2023
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11. Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study

Author

Aroori, Somaiah, Labib, Peter L., Russell, Thomas B., Streeter, Adam, Denson, Jemimah, Puckett, Mark, Browning, Matthew G., Ausania, Fabio, González-Abós, Carolina, Pando, Elizabeth, Fernandes, Nair, Moller, Elsa G., Taboada, Cristina D., Roberts, Keith J., Pande, Rupaly, Alfarah, Jameel, Kausar, Ambareen, Bandyopadhyay, Samik, Abdelrahim, Ahmed, Khan, Ayesha, Mavroeidis, Vasileios K., Jordan, Caitlin, Rees, Jonathan R.E., Marangoni, Gabriele, Blege, Collaborator: Harry, Thomasset, Sarah, Cambridge, William, White, Olga, Frampton, Adam, Blacker, Sarah, Blackburn, Jessie, Sweeney, Casie, Lykoudis, Pavlos, Field, Daniel, Gouda, Mohammed, Maglione, Manuel, Bellotti, Ruben, Alhaboob, Nassir, Hamid, Hytham K.S., Bari, Hassaan, Ahmed, Hassan, Smith, Andrew, Moriarty, Catherine, White, Louise, Priestley, Mark, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Craven, Samuel, Spalding, Duncan, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Onifade, Anjola, Srinivasan, Parthi, Ribaud, Julliette, Nair, Ashitha, Mariathasan, Michael, Grayson, Niamh, Davidson, Brian, Pericleous, Stephanos, Krishna Patel, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad K., Bhogal, Ricky, Doyle, Joseph, Croagh, Daniel, Dominguez, Ismael, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Thakkar, Rohan, Jones, Michael, Buckley, Edward, Akter, Nasreen, Treherne, Kyle, Gomez, Dhanny, Gordon, Gregory, Silva, Michael, Hughes, Daniel, Urbonas, Tomas, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Caronna, Roberto, Chirletti, Piero, Porcu, Alberto, Perra, Teresa, Shah, Nehal S., Abd Kahar, Nurul N., Hall, Thomas, Nadeem, Nabeegh, Hamady, Zaed, Karar, Shoura, Arshad, Ali, Al-Sarrieh, Bilal, Yarwood, Adam, Hammoda, Mohammed, Serrablo, Alejandro, Artigas, Maria, Paterna-López, Sandra, Thomasset, Sarah C., Frampton, Adam E., Smith, Andrew M., Davidson, Brian R., Bhogal, Ricky H., Silva, Michael A., and Hamady, Zaed Z.R.

Published
2023
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14. Can trainees safely perform pancreatoenteric anastomosis? A systematic review, meta-analysis, and risk-adjusted analysis of postoperative pancreatic fistula

Author

Pande, Rupaly, Halle-Smith, James M., Thorne, Thomas, Hiddema, Lydia, Hodson, James, Roberts, Keith J., Arshad, Ali, Connor, Saxon, Conlon, Kevin C.P., Dickson, Euan J., Giovinazzo, Francesco, Harrison, Ewen, de Liguori Carino, Nicola, Hore, Todd, Knight, Stephen R., Loveday, Benjamin, Magill, Laura, Mirza, Darius, Pandanaboyana, Sanjay, Perry, Rita J., Pinkney, Thomas, Siriwardena, Ajith K., Satoi, Sohei, Skipworth, James, Stättner, Stefan, Sutcliffe, Robert P., and Tingstedt, Bobby

Published
2022
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15. External validation of postoperative pancreatic fistula prediction scores in pancreatoduodenectomy: a systematic review and meta-analysis

Author

Pande, Rupaly, Halle-Smith, James M., Phelan, Liam, Thorne, Thomas, Panikkar, M., Hodson, James, Roberts, Keith J., Arshad, Ali, Connor, Saxon, Conlon, Kevin CP., Dickson, Euan J., Giovinazzo, Francesco, Harrison, Ewen, de Liguori Carino, Nicola, Hore, Todd, Knight, Stephen R., Loveday, Benjamin, Magill, Laura, Mirza, Darius, Pandanaboyana, Sanjay, Perry, Rita J., Pinkney, Thomas, Siriwardena, Ajith K., Satoi, Sohei, Skipworth, James, Stättner, Stefan, Sutcliffe, Robert P., and Tingstedt, Bobby

Published
2022
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17. Five-year recurrence/survival after pancreatoduodenectomy for pancreatic adenocarcinoma: does pre-existing diabetes matter? Results from the Recurrence After Whipple's (RAW) study

Author

Rajagopalan, Ashray, primary, Aroori, Somaiah, additional, Russell, Thomas B., additional, Labib, Peter L., additional, Ausania, Fabio, additional, Pando, Elizabeth, additional, Roberts, Keith J., additional, Kausar, Ambareen, additional, Mavroeidis, Vasileios K., additional, Marangoni, Gabriele, additional, Thomasset, Sarah C., additional, Frampton, Adam E., additional, Lykoudis, Pavlos, additional, Maglione, Manuel, additional, Alhaboob, Nassir, additional, Bari, Hassaan, additional, Smith, Andrew M., additional, Spalding, Duncan, additional, Srinivasan, Parthi, additional, Davidson, Brian R., additional, Bhogal, Ricky H., additional, Dominguez, Ismael, additional, Thakkar, Rohan, additional, Gomez, Dhanny, additional, Silva, Michael A., additional, Lapolla, Pierfrancesco, additional, Mingoli, Andrea, additional, Porcu, Alberto, additional, Shah, Nehal S., additional, Hamady, Zaed Z.R., additional, Al-Sarrieh, Bilal, additional, Serrablo, Alejandro, additional, Croagh, Daniel, additional, Gonzalez-Abos, Carolina, additional, Fernandes, Nair, additional, Moller, Elsa Garcia, additional, Taboada, Cristina Dopazo, additional, Roberts, Keith, additional, Pande, Rupaly, additional, Alfarah, Jameel, additional, Bandyopadhyay, Samik, additional, Abdelrahim, Ahmed, additional, Khan, Ayesha, additional, Jordan, Caitlin, additional, Rees, Jonathan R.E., additional, Blege, Harry, additional, Thomasset, Sarah, additional, Cambridge, William, additional, White, Olga, additional, Frampton, Adam, additional, Blacker, Sarah, additional, Blackburn, Jessie, additional, Sweeney, Casie, additional, Field, Daniel, additional, Gouda, Mohammed, additional, Bellotti, Ruben, additional, Hamid, Hytham K.S., additional, Ahmed, Hassan, additional, Smith, Andrew, additional, Moriarty, Catherine, additional, White, Louise, additional, Priestley, Mark, additional, Bode, Kerry, additional, Sharp, Judith, additional, Wragg, Rosie, additional, Jackson, Beverley, additional, Craven, Samuel, additional, Fehervari, Matyas, additional, Pai, Madhava, additional, Alghazawi, Laith, additional, Onifade, Anjola, additional, Ribaud, Julliette, additional, Nair, Ashitha, additional, Mariathasan, Michael, additional, Grayson, Niamh, additional, Davidson, Brian, additional, Pericleous, Stephanos, additional, Patel, Krishna, additional, Shaw, Conrad, additional, Morare, Nolitha, additional, Zaban, Mohamad Khish, additional, Bhogal, Ricky, additional, Doyle, Joseph, additional, Rajagopalan, Ashray, additional, Guerrero, Alan, additional, Moguel, Andre, additional, Chan, Carlos, additional, Jones, Michael, additional, Buckley, Edward, additional, Akter, Nasreen, additional, Treherne, Kyle, additional, Gordon, Gregory, additional, Silva, Michael, additional, Hughes, Daniel, additional, Urbonas, Tomas, additional, Brachini, Gioia, additional, Caronna, Roberto, additional, Chirletti, Piero, additional, Perra, Teresa, additional, Shah, Nehal Sureshkumar, additional, Abd Kahar, Nurul Nadhirah, additional, Hall, Thomas, additional, Nadeem, Nabeegh, additional, Hamady, Zaed, additional, Karar, Shoura, additional, Arshad, Ali, additional, Yarwood, Adam, additional, Hammoda, Mohammed, additional, Artigas, Maria, additional, Paterna-López, Sandra, additional, Streeter, Adam, additional, Denson, Jemimah, additional, Puckett, Mark, additional, Zhou, Shang-Ming, additional, and Browning, Matthew, additional

Published
2024
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19. Pathological complete response in patients with resected pancreatic adenocarcinoma after preoperative chemotherapy

Author

Stoop, Thomas F., Oba, Atsushi, Wu, Y H Andrew, Beaty, Laurel E., Colborn, Kathryn L., Janssen, Boris V., Al-Musawi, Mohammed H., Franco, Salvador Rodriguez, Sugawara, Toshitaka, Franklin, Oskar, Jain, Ajay, Saiura, Akio, Sauvanet, Alain, Coppola, Alessandro, Javed, Ammar A., Groot Koerkamp, Bas, Miller, Braden N., Mack, Claudia E., Hashimoto, Daisuke, Caputo, Damiano, Kleive, Dyre, Sereni, Elisabetta, Belfiori, Giulio, Ichida, Hirofumi, van Dam, Jacob L., Dembinski, Jeanne, Akahoshi, Keiichi, Roberts, Keith J., Tanaka, Kimitaka, Labori, Knut J., Falconi, Massimo, House, Michael G., Sugimoto, Motokazu, Tanabe, Minoru, Gotohda, Naoto, Krohn, Paul S., Burkhart, Richard A., Thakkar, Rohan G., Pande, Rupaly, Dokmak, Safi, Hirano, Satoshi, Burgdorf, Stefan K., Crippa, Stefano, van Roessel, Stijn, Satoi, Sohei, White, Steven A., Hackert, Thilo, Nguyen, Trang K., Yamamoto, Tomohisa, Nakamura, Toru, Bachu, Vismaya, Burns, William R., Inoue, Yosuke, Takahashi, Yu, Ushida, Yuta, Aslami, Zohra V., Verbeke, Caroline S., Fariña, Arantza, He, Jin, Wilmink, Johanna W., Messersmith, Wells, Verheij, Joanne, Kaplan, Jeffrey, Schulick, Richard D., Besselink, Marc G., Del Chiaro, Marco, Stoop, Thomas F., Oba, Atsushi, Wu, Y H Andrew, Beaty, Laurel E., Colborn, Kathryn L., Janssen, Boris V., Al-Musawi, Mohammed H., Franco, Salvador Rodriguez, Sugawara, Toshitaka, Franklin, Oskar, Jain, Ajay, Saiura, Akio, Sauvanet, Alain, Coppola, Alessandro, Javed, Ammar A., Groot Koerkamp, Bas, Miller, Braden N., Mack, Claudia E., Hashimoto, Daisuke, Caputo, Damiano, Kleive, Dyre, Sereni, Elisabetta, Belfiori, Giulio, Ichida, Hirofumi, van Dam, Jacob L., Dembinski, Jeanne, Akahoshi, Keiichi, Roberts, Keith J., Tanaka, Kimitaka, Labori, Knut J., Falconi, Massimo, House, Michael G., Sugimoto, Motokazu, Tanabe, Minoru, Gotohda, Naoto, Krohn, Paul S., Burkhart, Richard A., Thakkar, Rohan G., Pande, Rupaly, Dokmak, Safi, Hirano, Satoshi, Burgdorf, Stefan K., Crippa, Stefano, van Roessel, Stijn, Satoi, Sohei, White, Steven A., Hackert, Thilo, Nguyen, Trang K., Yamamoto, Tomohisa, Nakamura, Toru, Bachu, Vismaya, Burns, William R., Inoue, Yosuke, Takahashi, Yu, Ushida, Yuta, Aslami, Zohra V., Verbeke, Caroline S., Fariña, Arantza, He, Jin, Wilmink, Johanna W., Messersmith, Wells, Verheij, Joanne, Kaplan, Jeffrey, Schulick, Richard D., Besselink, Marc G., and Del Chiaro, Marco

Abstract

Importance: Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) in a small subset of patients. However, multicenter studies with in-depth data about pCR are lacking. Objective: To investigate the incidence, outcome, and risk factors of pCR after preoperative chemo(radio)therapy. Design, Setting, and Participants: This observational, international, multicenter cohort study assessed all consecutive patients with pathology-proven localized pancreatic adenocarcinoma who underwent resection after 2 or more cycles of chemotherapy (with or without radiotherapy) in 19 centers from 8 countries (January 1, 2010, to December 31, 2018). Data collection was performed from February 1, 2020, to April 30, 2022, and analyses from January 1, 2022, to December 31, 2023. Median follow-up was 19 months. Exposures: Preoperative chemotherapy (with or without radiotherapy) followed by resection. Main Outcomes and Measures: The incidence of pCR (defined as absence of vital tumor cells in the sampled pancreas specimen after resection), its association with OS from surgery, and factors associated with pCR. Factors associated with overall survival (OS) and pCR were investigated with Cox proportional hazards and logistic regression models, respectively. Results: Overall, 1758 patients (mean [SD] age, 64 [9] years; 879 [50.0%] male) were studied. The rate of pCR was 4.8% (n = 85), and pCR was associated with OS (hazard ratio, 0.46; 95% CI, 0.26-0.83). The 1-, 3-, and 5-year OS rates were 95%, 82%, and 63% in patients with pCR vs 80%, 46%, and 30% in patients without pCR, respectively (P < .001). Factors associated with pCR included preoperative multiagent chemotherapy other than (m)FOLFIRINOX ([modified] leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin) (odds ratio [OR], 0.48; 95% CI, 0.26-0.87), preoperative conventional radiotherapy (OR, 2.03; 95%

Published
2024
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20. Margin clearance greater than 1 mm in nodal-positive pancreatic adenocarcinoma patients : multicentre retrospective analysis

Author

Ahola, Reea P., Zwart, Eline S., Kurlinkus, Benediktas, Halimi, Asif, Yilmaz, Bengi S., Belfiori, Giulio, Roberts, Keith, Pande, Rupaly, Al-Saffar, Hasan A., Maisonneuve, Patrick, Ceyhan, Güralp O., Laukkarinen, Johanna, Ahola, Reea P., Zwart, Eline S., Kurlinkus, Benediktas, Halimi, Asif, Yilmaz, Bengi S., Belfiori, Giulio, Roberts, Keith, Pande, Rupaly, Al-Saffar, Hasan A., Maisonneuve, Patrick, Ceyhan, Güralp O., and Laukkarinen, Johanna

Abstract

Background: The introduction of the 1 mm cut-off for resection margin according to the Leeds Pathology Protocol has transformed the concept of surgical radicality. Its impact on nodal-positive resected pancreatic ductal adenocarcinoma patients is unclear. The aim of this study was to analyse the effect of margin clearance on survival among resected, nodal-positive pancreatic ductal adenocarcinoma patients whose specimens were analysed according to the Leeds Pathology Protocol. Methods: Data were collected retrospectively from multicentre clinical databases. Resected patients with nodal involvement were included. Overall survival and disease-free survival were analysed according to minimum reported margin clearances of 0, 0.5, 1, and 2 mm. The results are reported separately for patients who had not undergone venous resection and for patients for whom data were available regarding the superior mesenteric vein-facing margin or the vein specimen. The eighth edition of TNM classification by the AJCC was used. Results: The study comprised 290 stage IIB patients and 215 stage III patients without venous resection. The superior mesenteric vein margin analysis comprised 127 stage IIB patients and 198 stage III patients. The different resection margin distances were not associated with overall survival and disease-free survival among patients without venous resection (P > 0.050). Receiving adjuvant therapy was associated with longer overall survival among stage IIB patients (P = 0.034) and stage III patients (P = 0.003) and with longer disease-free survival among stage III patients (P < 0.001). Conclusions: In this study, a margin clearance greater than 1 mm showed no clear effect on overall survival in pancreatic ductal adenocarcinoma patients with nodal involvement, whereas adjuvant therapy was confirmed to be essential to ensure longer overall survival.

Published
2024
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21. Margin clearance greater than 1 mm in nodal-positive pancreatic adenocarcinoma patients: multicentre retrospective analysis.

Author

Ahola, Reea P, Zwart, Eline S, Kurlinkus, Benediktas, Halimi, Asif, Yilmaz, Bengi S, Belfiori, Giulio, Roberts, Keith, Pande, Rupaly, Al-Saffar, Hasan A, Maisonneuve, Patrick, Ceyhan, Güralp O, and Laukkarinen, Johanna

Subjects
MESENTERIC veins, PANCREATIC duct, PROGRESSION-free survival, OVERALL survival, SURGICAL margin
Abstract

Background The introduction of the 1 mm cut-off for resection margin according to the Leeds Pathology Protocol has transformed the concept of surgical radicality. Its impact on nodal-positive resected pancreatic ductal adenocarcinoma patients is unclear. The aim of this study was to analyse the effect of margin clearance on survival among resected, nodal-positive pancreatic ductal adenocarcinoma patients whose specimens were analysed according to the Leeds Pathology Protocol. Methods Data were collected retrospectively from multicentre clinical databases. Resected patients with nodal involvement were included. Overall survival and disease-free survival were analysed according to minimum reported margin clearances of 0, 0.5, 1, and 2 mm. The results are reported separately for patients who had not undergone venous resection and for patients for whom data were available regarding the superior mesenteric vein-facing margin or the vein specimen. The eighth edition of TNM classification by the AJCC was used. Results The study comprised 290 stage IIB patients and 215 stage III patients without venous resection. The superior mesenteric vein margin analysis comprised 127 stage IIB patients and 198 stage III patients. The different resection margin distances were not associated with overall survival and disease-free survival among patients without venous resection (P > 0.050). Receiving adjuvant therapy was associated with longer overall survival among stage IIB patients (P = 0.034) and stage III patients (P = 0.003) and with longer disease-free survival among stage III patients (P < 0.001). Conclusions In this study, a margin clearance greater than 1 mm showed no clear effect on overall survival in pancreatic ductal adenocarcinoma patients with nodal involvement, whereas adjuvant therapy was confirmed to be essential to ensure longer overall survival. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Staging Computed Tomography Parameters Predict the Need for Vein Resection during Pancreaticoduodenectomy in Resectable Pancreatic Ductal Adenocarcinoma

Author

Pande, Rupaly, primary, Liu, Wingyan, additional, Raza, Syed S., additional, Papamichail, Michail, additional, Suthananthan, Arul E., additional, Bartlett, David C., additional, Marudanayagam, Ravi, additional, Dasari, Bobby V. M., additional, Sutcliffe, Robert P., additional, Roberts, Keith J., additional, Wadhwani, Sharan, additional, and Chatzizacharias, Nikolaos, additional

Published
2024
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26. Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study.

Author

Lucocq, James, Hawkyard, Jake, Haugk, Beate, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby, Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, and Nunes, Quentin

Subjects
ADJUVANT chemotherapy, PROPENSITY score matching, TUMORS, ADENOCARCINOMA, OVERALL survival
Abstract

Background: The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemotherapy and its impact on recurrence and survival. Methods: This was a multicentre retrospective study of patients undergoing pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia between January 2010 and December 2020 at 18 centres. Recurrence and survival outcomes for patients who did and did not receive adjuvant chemotherapy were compared using propensity score matching. Results: Of 459 patients who underwent pancreatic resection, 275 (59.9%) received adjuvant chemotherapy (gemcitabine 51.3%, gemcitabine–capecitabine 21.8%, FOLFIRINOX 8.0%, other 18.9%). Median follow-up was 78 months. The overall recurrence rate was 45.5% and the median time to recurrence was 33 months. In univariable analysis in the matched cohort, adjuvant chemotherapy was not associated with reduced overall (P = 0.713), locoregional (P = 0.283) or systemic (P = 0.592) recurrence, disease-free survival (P = 0.284) or overall survival (P = 0.455). Adjuvant chemotherapy was not associated with reduced site-specific recurrence. In multivariable analysis, there was no association between adjuvant chemotherapy and overall recurrence (HR 0.89, 95% c.i. 0.57 to 1.40), disease-free survival (HR 0.86, 0.59 to 1.30) or overall survival (HR 0.77, 0.50 to 1.20). Adjuvant chemotherapy was not associated with reduced recurrence in any high-risk subgroup (for example, lymph node-positive, higher AJCC stage, poor differentiation). No particular chemotherapy regimen resulted in superior outcomes. Conclusion: Chemotherapy following resection of adenocarcinoma arising from intraductal papillary mucinous neoplasia does not appear to influence recurrence rates, recurrence patterns or survival. The present study aimed to identify factors related to receipt of adjuvant chemotherapy, the type, and its impact on recurrence, site-specific recurrence, and survival in a large international cohort of patients who underwent resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia (IPMN). Based on the contemporary data, adjuvant chemotherapy after pancreatic resection for adenocarcinoma arising from IPMN does not appear to influence recurrence rates, recurrence patterns or long-term survival. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Recurrence, recurrence patterns and management of recurrence after resection for invasive IPMN: data from 466 consecutive patients from a multicentre international cohort study

Author

Robertson, Francis, primary, Lucocq, James, additional, Hawkyard, Jake, additional, Haugk, Beate, additional, Mownah, Omar, additional, Menon, Krishna, additional, Furukawa, Takaaki, additional, Inoue, Yosuke, additional, Hirose, Yuki, additional, Sasahira, Naoki, additional, Feretis, Michael, additional, Balakrishnan, Anita, additional, Teresa, Carlo, additional, Davidson, Brian, additional, Pande, Rupaly, additional, Dasari, Bobby, additional, Roberts, Keith, additional, Tanno, Lulu, additional, Karavias, Dimitrios, additional, Helliwell, Jack, additional, Young, Alistair, additional, Nunes, Quentin, additional, Urbonas, Thomas, additional, Silva, Michael, additional, Gordon-Weeks, Alex, additional, Barrie, Jenifer, additional, Gomez, Dhanny, additional, Vanlaarhoven, Stijn, additional, Doyle, Joseph, additional, Bhogal, Ricky, additional, Harrison, Ewen, additional, Soreide, Kjetil, additional, Roalso, Marcus, additional, Ciprani, Deborah, additional, Aroori, Somaiah, additional, Denson, Jemimah, additional, Ratnayake, Bathiya, additional, Koea, Jonathan, additional, Capurso, Gabrielle, additional, Stattner, Stefan, additional, Bellotti, Ruben, additional, Alsaoudi, Tareq, additional, Bhardwaj, Neil, additional, Rajesh, Srujan, additional, Jeffery, Fraser, additional, Connor, Saxon, additional, Cameron, Andrew, additional, Jamieson, Nigel, additional, Sheen, Amy, additional, Mittal, Anubhav, additional, Samara, Jas, additional, Gill, Anthony, additional, and Pandanaboyana, Sanjay, additional

Published
2023
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28. Adjuvant chemotherapy does not impact on survival outcomes after resection for Invasive IPMN: data from 466 consecutive patients from an international multicentre cohort study

Author

Robertson, Francis, primary, Lucocq, James, additional, Hawkyard, Jake, additional, Hague, Beate, additional, Mownah, Omar, additional, Menon, Krishna, additional, Furukawa, Takaaki, additional, Inoue, Yosuke, additional, Hirose, Yuki, additional, Sasahira, Naoki, additional, Feretis, Michael, additional, Balakrishnan, Anita, additional, Ceresa, Carlo, additional, Davidson, Brian, additional, Pande, Rupaly, additional, Dasri, Bobby, additional, Roberts, Keith, additional, Tanno, Lulu, additional, Karavias, Dimitrios, additional, Helliwell, Jack, additional, Young, Alistair, additional, Nunes, Quentin, additional, Urbonas, Tomas, additional, Silva, Michael, additional, Gordon-Weeks, Alex, additional, Barrie, Jenifer, additional, Gomez, Dhanny, additional, Vanlaarhoven, Stijn, additional, Doyle, Joseph, additional, Bhogal, Ricky, additional, Harrison, Ewen, additional, Soreide, Kjetil, additional, Roalso, Marcus, additional, Ciprani, Deborah, additional, Aroori, Somaiah, additional, Denson, Jemimah, additional, Ratnayake, Bathiya, additional, Koea, Jonathan, additional, Capurso, Gabriele, additional, Stattner, Stefan, additional, Bellotti, Ruben, additional, Alsoudi, Tareq, additional, Bhardwaj, Neil, additional, Rajesh, Srujan, additional, Jeffery, Fraser, additional, Connor, Saxon, additional, Cameron, Andrew, additional, Jamieson, Nigel, additional, Sheen, Amy, additional, Mittal, Anubhav, additional, Samra, Jas, additional, Gill, Anthony, additional, and Pandanaboyana, Sanjay, additional

Published
2023
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29. Risk of Recurrence after Surgical Resection for Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasia (IPMN) with Patterns of Distribution and Treatment

Author

Lucocq, James, primary, Hawkyard, Jake, additional, Robertson, Francis P., additional, Haugk, Beate, additional, Lye, Jonathan, additional, Parkinson, Daniel, additional, White, Steve, additional, Mownah, Omar, additional, Zen, Yoh, additional, Menon, Krishna, additional, Furukawa, Takaaki, additional, Inoue, Yosuke, additional, Hirose, Yuki, additional, Sasahira, Naoki, additional, Feretis, Michael, additional, Balakrishnan, Anita, additional, Zelga, Piotr, additional, Ceresa, Carlo, additional, Davidson, Brian, additional, Pande, Rupaly, additional, Dasari, Bobby, additional, Tanno, Lulu, additional, Karavias, Dimitrios, additional, Helliwell, Jack, additional, Young, Alistair, additional, Nunes, Quentin, additional, Urbonas, Tomas, additional, Silva, Michael, additional, Gordon-Weeks, Alex, additional, Barrie, Jenifer, additional, Gomez, Dhanny, additional, van Laarhoven, Stijn, additional, Doyle, Joseph, additional, Bhogal, Ricky, additional, Harrison, Ewen, additional, Roalso, Marcus, additional, Ciprani, Debora, additional, Aroori, Somaiah, additional, Ratnayake, Bathiya, additional, Koea, Jonathan, additional, Capurso, Gabriele, additional, Bellotti, Ruben, additional, Stättner, Stefan, additional, Alsaoudi, Tareq, additional, Bhardwaj, Neil, additional, Jeffery, Fraser, additional, Connor, Saxon, additional, Cameron, Andrew, additional, Jamieson, Nigel, additional, Sheen, Amy, additional, Mittal, Anubhav, additional, Samra, Jas, additional, Gill, Anthony, additional, Roberts, Keith, additional, Soreide, Kjetil, additional, and Pandanaboyana, Sanjay, additional

Published
2023
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30. Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Results from the recurrence after Whipple's (RAW) study

Author

Russell, Thomas B., primary, Labib, Peter L., additional, Ausania, Fabio, additional, Pando, Elizabeth, additional, Roberts, Keith J., additional, Kausar, Ambareen, additional, Mavroeidis, Vasileios K., additional, Marangoni, Gabriele, additional, Thomasset, Sarah C., additional, Frampton, Adam E., additional, Lykoudis, Pavlos, additional, Maglione, Manuel, additional, Alhaboob, Nassir, additional, Bari, Hassaan, additional, Smith, Andrew M., additional, Spalding, Duncan, additional, Srinivasan, Parthi, additional, Davidson, Brian R., additional, Bhogal, Ricky H., additional, Croagh, Daniel, additional, Dominguez, Ismael, additional, Thakkar, Rohan, additional, Gomez, Dhanny, additional, Silva, Michael A., additional, Lapolla, Pierfrancesco, additional, Mingoli, Andrea, additional, Porcu, Alberto, additional, Shah, Nehal S., additional, Hamady, Zaed Z.R., additional, Al-Sarrieh, Bilal, additional, Serrablo, Alejandro, additional, Aroori, Somaiah, additional, Russell, Thomas B., additional, Streeter, Adam, additional, Denson, Jemimah, additional, Puckett, Mark, additional, Zhou, Shang-Ming, additional, Browning, Matthew, additional, Roberts, Keith, additional, Thomasset, Sarah, additional, Frampton, Adam, additional, Smith, Andrew, additional, Davidson, Brian, additional, Bhogal, Ricky, additional, Silva, Michael, additional, Shah, Nehal Sureshkumar, additional, Hamady, Zaed, additional, Gonzalez-Abos, Carolina, additional, Fernandes, Nair, additional, Moller, Elsa Garcia, additional, Taboada, Cristina Dopazo, additional, Pande, Rupaly, additional, Alfarah, Jameel, additional, Bandyopadhyay, Samik, additional, Abdelrahim, Ahmed, additional, Khan, Ayesha, additional, Jordan, Caitlin, additional, Rees, Jonathan R.E., additional, Blege, Harry, additional, Cambridge, William, additional, White, Olga, additional, Blacker, Sarah, additional, Blackburn, Jessie, additional, Sweeney, Casie, additional, Field, Daniel, additional, Gouda, Mohammed, additional, Bellotti, Ruben, additional, Hamid, Hytham K.S., additional, Ahmed, Hassan, additional, Moriarty, Catherine, additional, White, Louise, additional, Priestley, Mark, additional, Bode, Kerry, additional, Sharp, Judith, additional, Wragg, Rosie, additional, Jackson, Beverley, additional, Craven, Samuel, additional, Fehervari, Matyas, additional, Pai, Madhava, additional, Alghazawi, Laith, additional, Onifade, Anjola, additional, Ribaud, Julliette, additional, Nair, Ashitha, additional, Mariathasan, Michael, additional, Grayson, Niamh, additional, Pericleous, Stephanos, additional, Patel, Krishna, additional, Shaw, Conrad, additional, Morare, Nolitha, additional, Zaban, Mohamad Khish, additional, Doyle, Joseph, additional, Guerrero, Alan, additional, Moguel, Andre, additional, Chan, Carlos, additional, Jones, Michael, additional, Buckley, Edward, additional, Akter, Nasreen, additional, Treherne, Kyle, additional, Gordon, Gregory, additional, Hughes, Daniel, additional, Urbonas, Tomas, additional, Brachini, Gioia, additional, Caronna, Roberto, additional, Chirletti, Piero, additional, Perra, Teresa, additional, Abd Kahar, Nurul Nadhirah, additional, Hall, Thomas, additional, Nadeem, Nabeegh, additional, Karar, Shoura, additional, Arshad, Ali, additional, Yarwood, Adam, additional, Hammoda, Mohammed, additional, Artigas, Maria, additional, and Paterna-López, Sandra, additional

Published
2023
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34. HPB P49 Vein wall invasion is a more reliable predictor of oncological outcomes than vein related surgical margins after pancreaticoduodenectomy for early stages of pancreatic ductal adenocarcinoma

Author

Ahuja, Manish, primary, Pande, Rupaly, additional, Raza, Syed Soulat, additional, Bartlett, David C, additional, Dasari, Bobby, additional, Marudanayagam, Ravi, additional, Mirza, Darius, additional, Roberts, Keith John, additional, Issac, John, additional, Sutcliffe, Robert P, additional, and Chatzizacharias, Nikolaos A, additional

Published
2022
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35. HPB P14 Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma

Author

Pande, Rupaly, primary, Chughtai, Shafiq, additional, Ahuja, Manish, additional, Brown, Rachel, additional, Dasari, Bobby, additional, Marudanayagam, Ravi, additional, Mirza, Darius, additional, Roberts, Keith, additional, Sutcliffe, Robert, additional, Isaac, John, additional, and Chatzizacharias, Nikolaos, additional

Published
2022
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37. HPB P03 Oncological outcomes are comparable between octogenarians and younger patients after pancreatoduodenectomy for pancreatic ductal adenocarcinoma

Author

Pande, Rupaly, primary, Attard, Joseph, additional, Al-Sarireh, Bilal, additional, Bhogal, Ricky, additional, Farrugia, Alexia, additional, Fusai, Giuseppe, additional, Harper, Simon, additional, Hidalgo-Salinas, Camila, additional, Jah, Asif, additional, Marangoni, Gabriele, additional, Mortimer, Matthew, additional, Pizanias, Michail, additional, Prachialias, Andreas, additional, Roberts, Keith, additional, Hee, Chloe Sew, additional, Soggiu, Fiammetta, additional, Srinivasan, Parthi, additional, and Chatzizacharias, Nikolaos A, additional

Published
2022
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38. Oncological outcomes after pancreatoduodenectomy for pancreatic ductal adenocarcinoma in octogenarians: case-control study.

Author

Pande, Rupaly, Attard, Joseph A, Al-Sarireh, Bilal, Bhogal, Ricky Harminder, Farrugia, Alexia, Fusai, Giuseppe, Harper, Simon, Hidalgo-Salinas, Camila, Jah, Asif, Marangoni, Gabriele, Mortimer, Matthew, Pizanias, Michail, Prachialias, Andreas, Roberts, Keith J, Hee, Chloe Sew, Soggiu, Fiammetta, Srinivasan, Parthi, and Chatzizacharias, Nikolaos A

Subjects
PANCREATIC duct, OCTOGENARIANS, PANCREATICODUODENECTOMY, CASE-control method, ADENOCARCINOMA, PANCREATIC intraepithelial neoplasia, EXOCRINE pancreatic insufficiency
Abstract

Background By the end of this decade, 70 per cent of all diagnosed pancreatic ductal adenocarcinomas will be in the elderly. Surgical resection is the only curative option. In the elderly perioperative mortality is higher, while controversy still exists as to whether aggressive treatment offers any survival benefit. This study aimed to assess the oncological benefit of pancreatoduodenectomy in octogenarians with pancreatic ductal adenocarcinoma. Method Retrospective multicentre case-control study of octogenarians and younger controls who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 2008 and 2017. The primary endpoint was overall survival and the secondary endpoint was disease-free survival. Results Overall, 220 patients were included. Although the Charlson co-morbidity index was higher in octogenerians, Eastern Cooperative Oncology Group performance status, ASA and pathological parameters were comparable. Adjuvant therapy was more frequently delivered in the younger group (n = 80, 73 per cent versus n = 58, 53 per cent, P = 0.006). There was no significant difference between octogenarians and controls in overall survival (20 versus 29 months, P = 0.095) or disease-free survival (19 versus 22 months, P = 0.742). On multivariable analysis, age was not an independent predictor of either oncological outcome measured. Conclusion Octogenarians with pancreatic ductal adenocarcinoma of the head and uncinate process may benefit from comparable oncological outcomes to younger patients with surgical treatment. Due to the age- and disease-related frailty and co-morbidities, careful preoperative assessment and patient selection is of paramount importance. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma

Author

Pande, Rupaly, primary, Chughtai, Shafiq, additional, Ahuja, Manish, additional, Brown, Rachel, additional, Bartlett, David C, additional, Dasari, Bobby V, additional, Marudanayagam, Ravi, additional, Mirza, Darius, additional, Roberts, Keith, additional, Isaac, John, additional, Sutcliffe, Robert P, additional, and Chatzizacharias, Nikolaos A, additional

Published
2022
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44. P-P48 Clinical Benefit of Surveillance after Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis

Author

Halle-Smith, James, primary, Hall, Lewis, additional, Daamen, Lois, additional, Hodson, James, additional, Pande, Rupaly, additional, Young, Alastair, additional, Jamieson, Nigel, additional, Lamarca, Angela, additional, van Santvoort, Hjalmar, additional, Molenaar, Izaak Quintus, additional, Valle, Juan, additional, and Roberts, Keith, additional

Published
2021
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45. Clinical benefit of surveillance after resection of pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Author

Arts Assistenten CTC, MS CGO, Trialbureau Beeld, Cancer, MS HOD, Halle-Smith, James M., Hall, Lewis, Daamen, Lois A., Hodson, James, Pande, Rupaly, Young, Alastair, Jamieson, Nigel B., Lamarca, Angela, van Santvoort, Hjalmar C., Molenaar, Izaak Quintus, Valle, Juan W., Roberts, Keith J., Arts Assistenten CTC, MS CGO, Trialbureau Beeld, Cancer, MS HOD, Halle-Smith, James M., Hall, Lewis, Daamen, Lois A., Hodson, James, Pande, Rupaly, Young, Alastair, Jamieson, Nigel B., Lamarca, Angela, van Santvoort, Hjalmar C., Molenaar, Izaak Quintus, Valle, Juan W., and Roberts, Keith J.

Published
2021

49. Recurrence patterns of pancreatic cancer after pancreatoduodenectomy: systematic review and a single-centre retrospective study

Author

Kalisvaart, Marit, primary, Broadhurst, Damian, additional, Marcon, Francesca, additional, Pande, Rupaly, additional, Schlegel, Andrea, additional, Sutcliffe, Robert, additional, Marudanayagam, Ravi, additional, Mirza, Darius, additional, Chatzizacharias, Nikolaos, additional, Abradelo, Manuel, additional, Muiesan, Paolo, additional, Isaac, John, additional, Ma, Yuk T., additional, McConville, Christopher, additional, and Roberts, Keith, additional

Published
2020
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50. Systematic review and meta-analysis of factors associated with post-operative pancreatic fistula following pancreatoduodenectomy.

Author

Kamarajah, Sivesh K., Bundred, James R., Lin, Aaron, Halle-Smith, James, Pande, Rupaly, Sutcliffe, Robert, Harrison, Ewen M., and Roberts, Keith J.

Abstract

Background: Many studies have explored factors relating to post-operative pancreatic fistula (POPF); however, the original definition (All-POPF) was revised to include only ‘clinically relevant’ (CR) POPF. This study identified variables associated with the two International Study Group on Pancreatic Surgery definitions to identify which variables are more strongly associated with CR-POPF. Methods: A systematic review identified all studies reporting risk factors for POPF (using both International Study Group on Pancreatic Fistula definitions) following pancreatoduodenectomy. The primary outcome was factors associated with CR-POPF. Meta-analyses (random effects models) of pre-, intra- and post-operative factors associated with POPF in more than two studies were included. Results: Among 52 774 patients All-POPF (n = 69 studies) and CR-POPF (n = 53 studies) affected 27% (95% confidence interval (CI95%) 23–30) and 19% (CI95% 17–22), respectively. Of the 176 factors, 24 and 17 were associated with All- and CR-POPF, respectively. Absence of pre-operative pancreatitis, presence of renal disease, no pre-operative neoadjuvant therapy, use of post-operative somatostatin analogues, absence of associated venous or arterial resection were associated with CR-POPF but not All-POPF. Conclusion: In conclusion this study demonstrates wide variation in reported rates of POPF and that several risk factors associated with CR-POPF are not used within risk prediction models. Data from this study can be used to shape future studies, research and audit across ethnic and geographic boundaries in POPF following pancreatoduodenectomy. [ABSTRACT FROM AUTHOR]

Published
2021
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