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7. Clinical characteristics of patients with concurrent major depressive disorder and panic disorder

Author

Grunhaus, Leon, Pande, Atul C., Brown, Morton B., and Greden, John F.

Subjects
Depression, Mental -- Research, Panic disorders -- Research, Mentally ill -- Research, Health, Psychology and mental health
Abstract

Objective: This study was designed to test the hypothesis that patients with both major depressive disorder and panic disorder exhibit more clinical symptoms and have a more protracted course of illness than patients with major depressive disorder only. Method: The authors compared standardized clinical evaluations (from Schedule for Affective Disorders and Schizophrenia interviews) of 119 patients with major depressive disorder only and 57 patients with major depressive disorder and concurrent panic disorder. Clinical and demographic variables were included. Results: The patients with both disorders reported symptoms of major depressive disorder earlier in life and also required treatment and hospital admission earlier in life. Many clinical features during the index episode were significantly more severe in the patients with both disorders. A logistic regression identified a 'panic index' consisting of the symptoms of somatic anxiety, phobia, indecisiveness, and feelings of inadequacy. Scores on this index allowed proper classification of patients to either of the two diagnostic groups with high reliability. Conclusions: In major depressive disorder, the presence of panic disorder is suggestive of a more severe and precocious form of illness.

Published
1994

11. US immigration order strikes against biotech

Author

Levin, Jeremy M, primary, Holtzman, Steven H, additional, Maraganore, John, additional, Hastings, Paul J, additional, Cohen, Ron, additional, Dahiyat, Bassil, additional, Adams, Julian, additional, Adams, Chris, additional, Ahrens, Brett, additional, Albers, Jeff, additional, Aspinall, Mara G, additional, Audia, James E, additional, Babler, Martin, additional, Barrett, Peter, additional, Barry, Zoe, additional, Bermingham, Nessan, additional, Bloch, Stephen, additional, Blum, Robert I, additional, Bolno, Paul B, additional, Bonney, Michael W, additional, Booth, Bruce, additional, Bradbury, Daniel M, additional, Brauer, Steven K, additional, Byers, Brook, additional, Cagnoni, Pablo J, additional, Cali, Brian M, additional, Ciechanover, Isaac, additional, Clark, Chip, additional, Clayman, Michael D, additional, Cleland, Jeff L, additional, Cobb, Paula, additional, Cooper, Ron, additional, Currie, Mark G, additional, Diekman, John, additional, Dobmeier, Eric L, additional, Doerfler, Doug, additional, Donley, Elizabeth LR, additional, Dunsire, Deborah, additional, During, Matthew, additional, Eckstein, Jens W, additional, Elenko, Eric, additional, Exter, Neil A, additional, Fleming, Jonathan J, additional, Flesher, Gregory J, additional, Formela, Jean-Francois, additional, Forrester, Robert, additional, Francois, Cedric, additional, Franklin, Heather, additional, Freeman, Mason W, additional, Furst, Howard, additional, Gage, Leonard Patrick, additional, Galakatos, Nicholas, additional, Gallagher, Brian M, additional, Geraghty, James A, additional, Gill, Simba, additional, Goeddel, David V, additional, Goldsmith, Mark A, additional, Gowen, Maxine, additional, Goyal, Vikas, additional, Graney, Tom, additional, Grayzel, David, additional, Greene, Barry, additional, Grint, Paul, additional, Gutierrez-Ramos, J C, additional, Haney, Bill, additional, Ha-Ngoc, Tuan, additional, Harris, Tim, additional, Hasnain, Faheem, additional, Hata, Yujiro Steve, additional, Hecht, Peter, additional, Henshaw, Leslie, additional, Heyman, Rich, additional, Hoppenot, Herve, additional, Horvitz, H Robert, additional, Hughes, Thomas E, additional, Hutton, Wende S, additional, Isaacs, Stephen T, additional, Jenkins, Annalisa, additional, Jonker, Jeff, additional, Kaplan, Jeff, additional, Karsen, Perry, additional, Keiper, Jeb, additional, Kim, Jean, additional, Kindler, Jeff, additional, King, Rachel, additional, King, Vanessa, additional, Kjellson, Nina, additional, Koenig, Scott, additional, Koenig, Gerhard, additional, Kolchinsky, Peter, additional, Laikind, Paul, additional, Langer, Robert, additional, Lee, John J, additional, Leff, Jonathan S, additional, Leicher, Bruce A, additional, Leschly, Nick, additional, Levin, Andrew, additional, Levin, Mark, additional, Levine, Arnold J, additional, Levy, Alan, additional, Liu, David R, additional, Lodish, Harvey F, additional, Lopatin, Uri, additional, Love, Ted W, additional, Macdonald, Guy, additional, Maderis, Gail J, additional, Mahadevia, Ankit, additional, Mahanthappa, Nagesh K, additional, Martin, Joel F, additional, Martin, Alex, additional, Martucci, W Eddie, additional, McArthur, James G, additional, McCann, Corey M, additional, McCarthy, Sean A, additional, McDonough, C Geoffrey, additional, Mendlein, John, additional, Miller, Larry, additional, Miralles, Diego, additional, Moch, Kenneth I, additional, More, Bob, additional, Myers, Andrew G, additional, Narachi, Michael A, additional, Nashat, Amir, additional, Nelson, Wendy, additional, Newell, William J, additional, Olle, Bernat, additional, Osborn, John E, additional, Owens, Julia C, additional, Pande, Atul, additional, Papadopoulos, Stelios, additional, Parker, H Stewart, additional, Parmar, Kush M, additional, Patterson, Matthew R, additional, Paul, Steve M, additional, Perez, Rob, additional, Perry, Matthew, additional, Pfeffer, Cary G, additional, Powell, Mike, additional, Pruzanski, Mark, additional, Purcell, Dennis J, additional, Rakhit, Amit, additional, Ramamoorthi, Kartik, additional, Rastetter, William, additional, Rawcliffe, Adrian, additional, Reid, Laurence E, additional, Renaud, Ron C, additional, Rhodes, Jason P, additional, Rieflin, William J, additional, Robins, Chad, additional, Rocklage, Scott M, additional, Rosenblatt, Michael, additional, Rosin, Jonathan G, additional, Rutter, William J, additional, Saha, Saurabh, additional, Samuels, Camille, additional, Sato, Vicki L, additional, Scangos, George, additional, Scarlett, John A, additional, Schenkein, David, additional, Schreiber, Stuart L, additional, Schwab, Andrew, additional, Sekhri, Paul, additional, Shah, Rajeev, additional, Shenk, Thomas, additional, Siegall, Clay B, additional, Simon, Nick J, additional, Simonian, Nancy, additional, Stein, Jeff, additional, Su, Michael, additional, Szela, Mary T, additional, Taglietti, Marco, additional, Tandon, Nina, additional, Termeer, Henri, additional, Thornberry, Nancy A, additional, Tolar, Martin, additional, Ulevitch, Richard, additional, Vaishnaw, Akshay K, additional, VanLent, Anne, additional, Varsavsky, Martin, additional, Vlasuk, George P, additional, Vounatsos, Michel, additional, Waksal, Samuel G, additional, Warma, Neil, additional, Watts, Ryan J, additional, Werber, Yaron, additional, Westphal, Christoph, additional, Wierenga, Wendell, additional, Williams, Doug E, additional, Williams, Lewis, additional, Xanthopoulos, Kleanthis G, additional, Zohar, Daphne, additional, and Zweifach, Sandford, additional

Published
2017
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12. Shortened REM latency PostECT is associated with rapid recurrence of depressive symptomatology

Author

From the Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA, Grunhaus, Leon, Shipley, James E., Eiser, Alan S., Pande, Atul C., Tandon, Rajiv, Remen, Anna, Greden, John F., From the Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA, Grunhaus, Leon, Shipley, James E., Eiser, Alan S., Pande, Atul C., Tandon, Rajiv, Remen, Anna, and Greden, John F.

Abstract

Electroconvulsive therapy (ECT) is highly effective in the treatment of major depressive disorder (MDD). The 1-year relapse rates are reported to be high and in the 30%-60% range, however. To test whether polysomnography (PS) can identify patients with a propensity for relapse we studied 20 patients, responders to a course of ECT, with PS studies. All patients met baseline diagnostic criteria for MDD, were treated with ECT following standardized protocols, had PS studies performed after the course of ECT in a medication-free state, received maintenance antidepressants postECT, and were followed periodically with phone interviews. The recurrence of depressive symptoms was determined at 3 months and 6 months after discharge. Fifty-five percent of the patients were symptomatic when evaluated 6 months after the ECT. Sleep Onset rapid eye movement (REM) periods were identified in 55% of the patients. As a group, patients who had experienced a recurrence of depressive symptoms by 6 months after discharge, had significantly shorter REM latencies after the course of ECT. A shorter REM latency after ECT identified patients who at six months demonstrated significant depressive symptomatology. Shortened REM latency after ECT in patients with MDD appears to be a correlate of vulnerability for relapse.

Published
2006

13. Noradrenergic response to intravenous yohimbine in patients with depression and comorbidity of depression and panic

Author

College of Pharmacy and Department of Psychiatry, The University of Michigan, USA, Department of Psychiatry, The University of Michigan Medical School The University of Michigan, Ann Arbor, MI, USA, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA, Guthrie, Sally K., Grunhaus, Leon, Pande, Atul C., Hariharan, M., College of Pharmacy and Department of Psychiatry, The University of Michigan, USA, Department of Psychiatry, The University of Michigan Medical School The University of Michigan, Ann Arbor, MI, USA, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA, Guthrie, Sally K., Grunhaus, Leon, Pande, Atul C., and Hariharan, M.

Abstract

Adrenergic response following infusions of yohimbine or normal saline was evaluated in 9 control subjects, 8 patients suffering from a major depressive episode (MDE), and 12 patients suffering from concurrent MDE and panic disorder (MDE+P). Blood was drawn at -20, 0, 5, 10, 20, 45, and 90 min following the infusions, and assayed for norepinephrine (NE) and 3-methoxy-4-hydroxy-phenyl glycol (MHPG). Although the patient groups exhibited higher baseline NF concentrations, and a greater NE area under the plasma concentration versus time curve (AUC0-90) during the yohimbine infusion, the differences were not statistically significant. Baseline NE was significantly correlated with the NE AUC0-90 in all three groups, suggesting that, although the NE system may be dysregulated in the MDE and MDE+P patients, the NE system still appears to respond somewhat predictably following a challenge, even though the actual magnitude of response may vary.

Published
2006

14. Seasonality in atypical depression

Author

Depression Program, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USA, Pande, Atul C., Haskett, Roger F., Greden, John F., Depression Program, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USA, Pande, Atul C., Haskett, Roger F., and Greden, John F.

Published
2006

15. EEG sleep in cushing's disease and cushing's syndrome: comparison with patients with major depressive disorder

Author

Sleep Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Division of Endocrinology and Metabolism, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Schizophrenia Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Depression Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Consultation-Liaison Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Shipley, James E., Schteingart, David E., Tandon, Rajiv, Pande, Atul C., Grunhaus, Leon, Haskett, Roger F., Starkman, Monica N., Sleep Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Division of Endocrinology and Metabolism, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Schizophrenia Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Depression Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Consultation-Liaison Programs, Department of Psychiatry, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, Shipley, James E., Schteingart, David E., Tandon, Rajiv, Pande, Atul C., Grunhaus, Leon, Haskett, Roger F., and Starkman, Monica N.

Abstract

Because patients with Cushing' syndrome (CS) and Major depressive disorder (MDD) share features of hypercortisolism and the depressive syndrome, we compared electroencephalographic (EEG) sleep in patients with pituitary-ACTH-dependent Cushing's syndrome (Cushing's disease, CD), patients with ACTH-independent Cushing's syndrome (AICS), patients with major depressive disorder (MDD), and normal subjects. There were substantial similarities in the abnormal polysomnography profiles of patients with CD, AICS, and MDD. All three patient groups demonstrated poorer sleep continuity, shortened rapid eye movement (REM) latency, and increased first REM period density compared with normal subjects. In addition, AICS patients and MDD patients had elevated REM activity and density. These findings are discussed in terms of models of pathophysiology that relate abnormalities in sleep, mood, and hypothalamic-pituitary-adrenal function.

Published
2006

16. Monitoring of antidepressant response to ECT with polysomnographic recordings and the dexamethasone suppression test

Author

Electroconvulsive Therapy Program, Department of Psychiatry, The University of Michigan, USA, Clinical Studies Unit, Department of Psychiatry, The University of Michigan, USA, Outpatient Clinic, Department of Psychiatry, The University of Michigan, USA, Sleep Depression Unit, Department of Psychiatry, The University of Michigan, USA, Grunhaus, Leon, Tiongco, Dolores, Pande, Atul C., Eiser, Alan S., Haskett, Roger F., Greden, John F., Shipley, James E., Electroconvulsive Therapy Program, Department of Psychiatry, The University of Michigan, USA, Clinical Studies Unit, Department of Psychiatry, The University of Michigan, USA, Outpatient Clinic, Department of Psychiatry, The University of Michigan, USA, Sleep Depression Unit, Department of Psychiatry, The University of Michigan, USA, Grunhaus, Leon, Tiongco, Dolores, Pande, Atul C., Eiser, Alan S., Haskett, Roger F., Greden, John F., and Shipley, James E.

Abstract

Ten patients treated with electroconvulsive therapy (ECT) only were followed with serial sleep polysomnographic recordings and dexamethasone suppression tests (DSTs). Both biological correlates of depression showed improvement with ECT. The use of serial sleep measures and serial DSTs in monitoring the clinical response to ECT is discussed.

Published
2006

17. Predictors of response to electroconvulsive therapy in major depressive disorder

Author

From the Electroconvulsive Therapy Program and the Depression Program, University of Michigan Medical Center, Ann Arbor, MI, USA, Pande, Atul C., Krugler, Tina, Haskett, Roger F., Greden, John F., Grunhaus, Leon J., From the Electroconvulsive Therapy Program and the Depression Program, University of Michigan Medical Center, Ann Arbor, MI, USA, Pande, Atul C., Krugler, Tina, Haskett, Roger F., Greden, John F., and Grunhaus, Leon J.

Published
2006

21. Efficacy of the Novel Anxiolytic Pregabalin in Social Anxiety Disorder

Author

Pande, Atul C., primary, Feltner, Douglas E., additional, Jefferson, James W., additional, Davidson, Jonathan R.T., additional, Pollack, Mark, additional, Stein, Murray B., additional, Lydiard, R. Bruce, additional, Futterer, Rïse, additional, Robinson, Paula, additional, Slomkowski, Mary, additional, DuBoff, Eugene, additional, Phelps, Mary, additional, Janney, Carol A., additional, and Werth, John L., additional

Published
2004
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24. Treatment of Social Phobia With Gabapentin

Author

Pande, Atul C., primary, Davidson, Jonathan R. T., additional, Jefferson, James W., additional, Janney, Carol A., additional, Katzelnick, David J., additional, Weisler, Richard H., additional, Greist, John H., additional, and Sutherland, Suzanne M., additional

Published
1999
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34. Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients

Author

Heiligenstein, John H., primary, Faries, Douglas E., additional, John Rush, A., additional, Andersen, John S., additional, Pande, Atul C., additional, Roffwarg, Howard P., additional, Dunner, David, additional, Christian Gillin, J., additional, James, Steven P., additional, Lahmeyer, Henry, additional, Zajecka, John, additional, Tollefson, Gary D., additional, and Gardner, Dawn M., additional

Published
1994
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39. A Longitudinal Evaluation of

Author

GUTHRIE, SALLY K., primary, HEIDT, MICHAEL, additional, PANDE, ATUL, additional, GRUNHAUS, LEON, additional, HASKETT, ROGER F., additional, and HARIHARAN, M., additional

Published
1992
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49. Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy.

Author

Pande, Atul C, Crockatt, Jerri G, Janney, Carol A, Werth, John L, and Tsaroucha, Georgia

Subjects
*BIPOLAR disorder, *THERAPEUTICS, *AFFECTIVE disorders, *MENTAL health services, *PLACEBOS, *HAMILTON Depression Inventory
Abstract

Objectives: To assess efficacy and safety of gabapentin in the treatment of bipolar disorder. 

Methods: This was a double‐blind, placebo‐controlled trial of adjunctive gabapentin (dosed flexibly between 900 and 3600 mg/day). Patients with a lifetime diagnosis of bipolar disorder (type I), and who were currently suffering from symptoms of either mania, hypomania or a mixed state despite ongoing therapy with lithium, valproate, or lithium and valproate in combination were eligible for inclusion. The primary efficacy measures were the baseline to endpoint change in total score on the Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAM‐D). 

Results: Both treatment groups had a decrease in total YMRS from baseline to endpoint, but this decrease was significantly greater in the placebo group (−9) than the gabapentin group (−6) (p<0.05). No difference between treatments was found for the total score on the HAM‐D. Secondary efficacy measures were not different between treatment groups. More patients in the placebo group had changes made to their ongoing lithium therapy (n=12) compared to the gabapentin group (n=4). When these patients are removed from the efficacy analysis, the YMRS treatment difference still favors placebo, but is no longer statistically significant. Based on gabapentin plasma levels at termination, some patients did not take the study drug as prescribed. 

Conclusions: The findings of this study did not demonstrate that gabapentin is an effective adjunctive treatment when administered to outpatients with bipolar disorder. [ABSTRACT FROM AUTHOR]

Published
2000
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50. Heterogeneity in the β-Endorphin Immunoreactivity Response to Electroconvulsive Therapy

Author

Young, Elizabeth A., Grunhaus, Leon, Haskett, Roger F., Pande, Atul C., Murphy-Weinberg, Virginia, Akil, Huda, and Watson, Stanley J.

Abstract

• Electroconvulsive therapy is accompanied by an activation of the hypothalamic-pituitary-adrenal axis, resulting in a release of β-endorphin from the anterior pituitary corticotrophs of humans. As a group, patients in our study demonstrated similar plasma β-endorphin immunoreactivity response to their initial and final treatments. However, approximately half of the patients demonstrated greater β-endorphin immunoreactivity release with their first seizure compared with their last seizure, and half of the patients demonstrated the opposite pattern. This difference was not explained by age, sex, unilateral vs bilateral treatments, sine wave vs brief pulse, or psychotropic or anticholinergic medication. Patients with constant seizure duration during the first and final treatments demonstrated a greater release of β-endorphin immunoreactivity with the final treatment compared with the first treatment. Individuals with decreasing seizure duration during the course of the electroconvulsive therapy demonstrated a decreased β-endorphin immunoreactivity response during their final treatment.

Published
1991
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