Search

Your search keyword '"Pancreatic cancer -- Care and treatment -- Genetic aspects"' showing total 36 results
Start Over Descriptor "Pancreatic cancer -- Care and treatment -- Genetic aspects"
36 results on '"Pancreatic cancer -- Care and treatment -- Genetic aspects"'

1. University of Arkansas for Medical Sciences Researchers Further Understanding of Pancreatic Cancer (205 Targeting Homologous Repair to Overcome Genotoxic Therapy Resistance in Pancreatic Cancer)

Subjects
Oncology, Experimental, DNA repair -- Research, Cancer -- Research, Radiotherapy -- Methods, Pancreatic cancer -- Care and treatment -- Genetic aspects, Genetic recombination -- Research, Health
Abstract

2023 APR 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on pancreatic cancer have been published. According to news [...]

Published
2023

2. Protective autophagy elicited by RAF[right arrow]MEK[right arrow]ERK inhibition suggests a treatment strategy for RAS-driven cancers

Author

Kinsey, Conan G., Camolotto, Soledad A., Boespflug, Amelie M., Guillen, Katrin P., Foth, Mona, Truong, Amanda, and Schuman, Sophia S.

Subjects
Pancreatic cancer -- Care and treatment -- Genetic aspects, Cancer cells -- Research, Combination drug therapy -- Usage, Trametinib -- Usage, Cellular signal transduction -- Research, Hydroxychloroquine, Medical schools, Adenocarcinoma, Displays (Marketing), Cancer, Temsirolimus, Melanoma, Tetracyclines, Colorectal cancer, Tumors, Novels, Biological sciences, Health
Abstract

Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS.sup.1-4. Downstream of KRAS, the RAF[right arrow]MEK[right arrow]ERK signaling pathway plays a central role in pancreatic carcinogenesis.sup.5. However, paradoxically, inhibition of this pathway has provided no clinical benefit to patients with PDA.sup.6. Here we show that inhibition of KRAS[right arrow]RAF[right arrow]MEK[right arrow]ERK signaling elicits autophagy, a process of cellular recycling that protects PDA cells from the cytotoxic effects of KRAS pathway inhibition. Mechanistically, inhibition of MEK1/2 leads to activation of the LKB1[right arrow]AMPK[right arrow]ULK1 signaling axis, a key regulator of autophagy. Furthermore, combined inhibition of MEK1/2 plus autophagy displays synergistic anti-proliferative effects against PDA cell lines in vitro and promotes regression of xenografted patient-derived PDA tumors in mice. The observed effect of combination trametinib plus chloroquine was not restricted to PDA as other tumors, including patient-derived xenografts (PDX) of NRAS-mutated melanoma and BRAF-mutated colorectal cancer displayed similar responses. Finally, treatment of a patient with PDA with the combination of trametinib plus hydroxychloroquine resulted in a partial, but nonetheless striking disease response. These data suggest that this combination therapy may represent a novel strategy to target RAS-driven cancers. Targeted inhibition of RAF-MEK-ERK signaling induces autophagy through the LKB1-AMPK axis, creating a therapeutic vulnerability that can be exploited for treating patients with pancreatic cancer and potentially other RAS-mutant tumors., Author(s): Conan G. Kinsey [sup.1] [sup.2] , Soledad A. Camolotto [sup.1] , Amelie M. Boespflug [sup.1] [sup.3] [sup.4] , Katrin P. Guillen [sup.1] , Mona Foth [sup.1] , Amanda Truong [...]

Published
2019
Full Text
View/download PDF

3. Findings on Pancreatic Cancer Reported by Investigators at Johns Hopkins University (Giant Obscurin Regulates Migration and Metastasis Via Rhoa-dependent Cytoskeletal Remodeling In Pancreatic Cancer)

Subjects
Gene mutations -- Health aspects, Metastasis -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health, Johns Hopkins University -- Research
Abstract

2022 FEB 12 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Oncology - Pancreatic Cancer is now available. According [...]

Published
2022

4. Findings from National Cancer Institute (NCI) Has Provided New Data on Pancreatic Cancer (A Systematic Review of the Prevalence of Germline Pathogenic Variants In Patients With Pancreatic Cancer)

Subjects
United States. National Cancer Institute -- Reports, Oncology, Experimental -- Reports -- Genetic aspects, Cancer patients -- Care and treatment, Cancer -- Genetic aspects -- Research, Physical fitness -- Reports, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health
Abstract

2021 AUG 21 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Oncology - Pancreatic Cancer. According to news [...]

Published
2021

5. Computational modeling of cell signaling and mutations in pancreatic cancer

Subjects
Cancer -- Care and treatment -- Genetic aspects, Computer simulation -- Analysis -- Models, Physical fitness -- Models -- Analysis, Pancreatic cancer -- Care and treatment -- Genetic aspects, Computer-generated environments -- Analysis -- Models, Health
Abstract

2021 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2021

6. Reprogrammed Cells Tame a Deadly Cancer

Author

Kolata, Gina

Subjects
T cells -- Genetic aspects, Cancer -- Care and treatment, Pancreatic cancer -- Care and treatment -- Genetic aspects, General interest, News, opinion and commentary
Abstract

Another patient who had the same treatment did not survive. But the demonstration of the technique could help with other cancers. Researchers have managed to tame pancreatic cancer in a [...]

Published
2022

7. New Findings from H. Lee Moffitt Cancer Center and Research Institute in the Area of Cancer Reported (The Promise and Current Status of Cdk12/13 Inhibition for the Treatment of Cancer)

Subjects
Oncology, Experimental -- Reports -- Genetic aspects, Cancer -- Care and treatment -- Research, Genetic engineering -- Genetic aspects -- Reports, Physical fitness -- Reports, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health
Abstract

2021 JAN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Cancer is now available. According to news reporting [...]

Published
2021

8. New Findings from University of Southern Alabama in the Area of Personalized Medicine Described [Epidermal Growth Factor Receptor-activating Mutation(E746_t751 > Vp) In Pancreatic Ductal Adenocarcinoma Responds To Erlotinib, Followed By ...]

Subjects
Adenocarcinoma -- Care and treatment -- Genetic aspects, Antineoplastic agents, Physical fitness, Pancreatic cancer -- Care and treatment -- Genetic aspects, Epidermal growth factor -- Genetic aspects, Antimitotic agents, Health
Abstract

2021 JAN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Drugs and Therapies - Personalized Medicine. According [...]

Published
2021

9. EU approves Lynparza for patients with germline BRCA-mutated metastatic pancreatic cancer

Subjects
Merck & Company Inc., AstraZeneca PLC, Pancreatic cancer -- Care and treatment -- Genetic aspects, Olaparib, Pharmaceutical industry, Cancer patients -- Care and treatment, Cancer metastasis -- Care and treatment -- Genetic aspects, Pharmaceuticals and cosmetics industries, European Union, Lynparza (Medication)
Abstract

AstraZeneca and Merck announced that Lynparza (olaparib) has been approved in the European Union (EU) for patients with germline BRCA-mutated (gBRCAm) metastatic pancreatic cancer. Pancreatic cancer is a rare, life-threatening [...]

Published
2020

10. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Author

Bryant, Kirsten L., Stalnecker, Clint A., Zeitouni, Daniel, Klomp, Jennifer E., Peng, Sen, Tikunov, Andrey P., and Gunda, Venugopal

Subjects
Pancreatic cancer -- Care and treatment -- Genetic aspects, Autophagy (Cytology) -- Research, Gene mutation -- Research, Cellular signal transduction -- Research, Cancer treatment, Adenocarcinoma, Tumors, Biological sciences, Health
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been established. We show that, to our surprise, suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector ERK MAPK. Furthermore, we demonstrate that either KRAS suppression or ERK inhibition decreased both glycolytic and mitochondrial functions. We speculated that ERK inhibition might thus enhance PDAC dependence on autophagy, in part by impairing other KRAS- or ERK-driven metabolic processes. Accordingly, we found that the autophagy inhibitor chloroquine and genetic or pharmacologic inhibition of specific autophagy regulators synergistically enhanced the ability of ERK inhibitors to mediate antitumor activity in KRAS-driven PDAC. We conclude that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC. Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with autophagy inhibitors., Author(s): Kirsten L. Bryant [sup.1] , Clint A. Stalnecker [sup.1] , Daniel Zeitouni [sup.1] , Jennifer E. Klomp [sup.1] , Sen Peng [sup.2] , Andrey P. Tikunov [sup.3] , Venugopal [...]

Published
2019
Full Text
View/download PDF

11. Findings from Shanghai Jiao-Tong University in the Area of Adenocarcinoma Described (Sfrp4 Is a Prognostic Marker and Correlated With Treg Cell Infiltration In Pancreatic Ductal Adenocarcinoma)

Subjects
Pancreatic cancer -- Care and treatment -- Genetic aspects, Cellular signal transduction -- Analysis, Obesity, Adenocarcinoma, Apoptosis, Gene expression, Anopheles, Editors, Biochemistry, Genetic research, Health
Abstract

2019 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Oncology - Adenocarcinoma is the subject of a report. [...]

Published
2019

12. New Bioinformatics Findings from Second Affiliated Hospital of Chongqing Medical University Outlined (Identification of key pathways and candidate genes in pancreatic ductal adenocarcinoma using bioinformatics analysis)

Subjects
Computational biology -- Research, Gene expression -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Obesity, Cancer genetics, Adenocarcinoma, Physical fitness, Biotechnology, Tumors, Genes, Anopheles, Editors, Genetic research, Health
Abstract

2019 APR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Biotechnology - Bioinformatics are discussed in a new report. [...]

Published
2019

13. ImmunoGenesis Announces Positive Preclinical Glioblastoma and Pancreatic Cancer Data for STimulator of INterferon Genes (STING) Agonist Published in Two Scientific Journals

Subjects
Interferon, Genes -- Genetic aspects, Immunotherapy, Biological response modifiers -- Genetic aspects, Brain tumors -- Care and treatment -- Genetic aspects, Glioblastoma multiforme -- Care and treatment -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, General interest, News, opinion and commentary
Abstract

HOUSTON: ImmunoGenesis has issued the following news release: ImmunoGenesis Inc., a clinical-stage biotechnology company developing science-driven immune therapies, announces the publication of positive data for its STimulator of INterferon Genes [...]

Published
2021

14. Findings from University of California Yields New Data on Xenografts (Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models)

Subjects
Chemotherapy -- Usage, MicroRNA -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Xenotransplantation -- Research -- Usage, Obesity, Cancer research, Physical fitness, Tumors, Cancer cells, Editors, Health
Abstract

2019 FEB 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Biotechnology - Xenografts have been presented. According to news [...]

Published
2019

15. Study Results from Y. Zhao et al Provide New Insights into Pancreatic Cancer [Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 ...]

Subjects
Pancreatic cancer -- Care and treatment -- Genetic aspects, Health
Abstract

2018 DEC 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Oncology - Pancreatic Cancer are discussed in a new [...]

Published
2018

16. ImmunoGenesis Announces Positive Preclinical Glioblastoma and Pancreatic Cancer Data for STimulator of INterferon Genes (STING) Agonist Published in Two Scientific Journals

Subjects
Interferon, Genes -- Genetic aspects, Immunotherapy, Biological response modifiers -- Genetic aspects, Brain tumors -- Care and treatment -- Genetic aspects, Glioblastoma multiforme -- Care and treatment -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, Business, News, opinion and commentary
Abstract

STING agonist can induce innate immune responses that allow the immune system to fight otherwise immunologically resistant cancers Phase 1 canine glioblastoma veterinary trial data show the promise of STING [...]

Published
2021

17. A BREAK FROM CHEMO: PARP INHIBITOR SHRINKS TUMORS IN PANCREATIC CANCER PATIENTS WITH MUTATIONS

Subjects
Gene mutations -- Genetic aspects, Cancer patients -- Care and treatment, Chemotherapy, Cancer -- Chemotherapy, Pancreatic cancer -- Care and treatment -- Genetic aspects, News, opinion and commentary, University of Pennsylvania. Perelman School of Medicine, University of Pennsylvania. Abramson Cancer Center
Abstract

PHILADELPHIA, PA -- The following information was released by the University of Pennsylvania School of Medicine: Phase II study shows rucaparib helped control cancer growth in patients with BRCA or [...]

Published
2021

18. Findings from Fordham University Update Understanding of Molecular Modeling (In Silico Studies of Interactions of Peptide-conjugated Cholesterol Metabolites and Betulinic Acid With Egfr, Ldr, and N-terminal Fragment of Ccka Receptors)

Subjects
Cholesterol -- Chemical properties, Cholecystokinin -- Chemical properties, Pharmaceutical research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Biological sciences, Health
Abstract

2022 JAN 25 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Life Science Research - Molecular Modeling is now available. According [...]

Published
2022

20. How Do Our Genes Affect Pancreatic Cancer? Five Things to Know

Subjects
AstraZeneca PLC, Cancer treatment -- Health aspects, Cancer genetics -- Genetic aspects -- Care and treatment, Pancreatic cancer -- Care and treatment -- Genetic aspects, Olaparib -- Health aspects, Bevacizumab -- Health aspects, Genes -- Genetic aspects -- Health aspects, Gene mutation -- Genetic aspects -- Health aspects, Medical research -- Health aspects, News, opinion and commentary, Sports and fitness, Lynparza (Medication) -- Health aspects
Abstract

- The statistics around pancreatic cancer are grim. In the US this year, more than 57,000 people will be diagnosed and approximately 47,000 will die from the disease. Pancreatic cancer [...]

Published
2020

21. How Do Our Genes Affect Pancreatic Cancer? Five Things to Know

Subjects
AstraZeneca PLC, Cancer treatment -- Health aspects, Cancer genetics -- Genetic aspects -- Care and treatment, Pancreatic cancer -- Care and treatment -- Genetic aspects, Olaparib -- Health aspects, Bevacizumab -- Health aspects, Genes -- Genetic aspects -- Health aspects, Gene mutation -- Genetic aspects -- Health aspects, Medical research -- Health aspects, News, opinion and commentary, Sports and fitness, Lynparza (Medication) -- Health aspects
Abstract

- The statistics around pancreatic cancer are grim. In the US this year, more than 57,000 people will be diagnosed and approximately 47,000 will die from the disease. Pancreatic cancer [...]

Published
2020

22. How Do Our Genes Affect Pancreatic Cancer? Five Things to Know

Subjects
AstraZeneca PLC, Cancer treatment -- Health aspects, Cancer genetics -- Genetic aspects -- Care and treatment, Pancreatic cancer -- Care and treatment -- Genetic aspects, Olaparib -- Health aspects, Bevacizumab -- Health aspects, Genes -- Genetic aspects -- Health aspects, Gene mutation -- Genetic aspects -- Health aspects, Medical research -- Health aspects, News, opinion and commentary, Sports and fitness, Lynparza (Medication) -- Health aspects
Abstract

- The statistics around pancreatic cancer are grim. In the US this year, more than 57,000 people will be diagnosed and approximately 47,000 will die from the disease. Pancreatic cancer [...]

Published
2020

23. Research Conducted at Guangdong Medical University Has Provided New Information about Bioinformatics (Bioinformatics Analysis of a Prognostic Mirna Signature and Potential Key Genes In Pancreatic Cancer)

Subjects
Computational biology -- Genetic aspects, Gene expression -- Genetic aspects, Genes -- Genetic aspects, MicroRNA -- Genetic aspects, Cancer -- Care and treatment -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, Business, Health, Health care industry
Abstract

2021 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Biotechnology - Bioinformatics. According to news reporting from Dongguan, People's [...]

Published
2021

24. Investigators from Cincinnati Children's Hospital Medical Center Zero in on Personalized Medicine (The P.ser64leu and P.pro104leu Missense Variants of Palb2 Identified In Familial Pancreatic Cancer Patients Compromise the Dna Damage Response)

Subjects
Medical research, Medicine, Experimental, DNA repair -- Genetic aspects, Medical centers, DNA -- Genetic aspects, Cancer patients -- Care and treatment, Cancer -- Genetic aspects, DNA damage -- Genetic aspects, Epidemiology, Disease susceptibility -- Care and treatment -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health
Abstract

2021 JAN 22 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Drugs and Therapies - Personalized Medicine is now available. [...]

Published
2021

25. Reports from Third Affiliated Hospital of Shenzhen University Describe Recent Advances in Pancreatic Cancer (The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment)

Subjects
Genetic research -- Genetic aspects, Cancer genetics -- Genetic aspects -- Care and treatment, Pancreatic cancer -- Care and treatment -- Genetic aspects, Genes -- Genetic aspects, Gene mutation -- Genetic aspects, Adenocarcinoma, Anopheles, Tumors, Editors, Business, Health, Health care industry
Abstract

2020 MAY 19 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Oncology - Pancreatic Cancer. According to news reporting out of [...]

Published
2020

26. Study Yields Genetic Insights Into Pancreatic Cancer; Multiple gene mutations identified that could be targets for treatment

Subjects
Pancreatic cancer -- Care and treatment -- Genetic aspects, Gene mutation -- Health aspects, Molecular targeted therapy -- Innovations, Health
Abstract

THURSDAY, April 9, 2015 (HealthDay News) -- Most pancreatic cancers have gene mutations that could be targeted by existing drugs, a new study suggests. The researchers say the findings could [...]

Published
2015

27. Mucin 1 (MUC1) targeting peptide GO-203-2c (Genus Oncology)

Subjects
Genes -- Physiological aspects, Peptides -- Physiological aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, Pharmaceuticals and cosmetics industries
Abstract

Mucin 1 (MUC1) targeting peptide GO-203-2c (Genus Oncology) for the treatment of pancreatic [...]

Published
2011

28. Researchers at University of Texas Medical Branch Have Published New Data on Pancreatic Cancer

Subjects
Oncology, Experimental, Cancer -- Care and treatment -- Genetic aspects -- Research, Universities and colleges -- Texas, Pancreatic cancer -- Care and treatment -- Genetic aspects, Biotechnology industry, Health, Science and technology, University of Texas
Abstract

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Data detailed on Pancreatic Cancer have been presented. According to news reporting out of Galveston, Texas, by NewsRx [...]

Published
2012

29. Caring for Carcinoid Foundation-Funded Researchers Illuminate Genetic Code for a Form of Pancreatic Cancer

Subjects
Apple Inc., Oncology, Experimental, Genetic research, Computer industry, Cancer -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Microcomputer industry, Computer industry, Business, Health, Health care industry
Abstract

Through a grant provided by the Caring for Carcinoid Foundation (www.caringforcarcinoid.org), researchers at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center have discovered several key mutations in pancreatic neuroendocrine tumors. [...]

Published
2011

30. Researchers' work from University of Amsterdam focuses on cancer gene therapy

Subjects
University of Amsterdam, Oncology, Experimental -- Genetic aspects, Genetic research -- Genetic aspects, Gene therapy, Cancer -- Care and treatment -- Genetic aspects -- Research, Universities and colleges, Peptides -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects
Abstract

According to recent research from Netherlands, "Pancreatic cancer is an aggressive malignancy with a dismal prognosis. To improve treatment options new treatments, such as adenoviral (Ad) gene therapy are necessary." [...]

Published
2010

31. Researchers at National Cancer Center Research Institute release new data on cancer gene therapy

Subjects
Oncology, Experimental -- Genetic aspects, Antineoplastic agents -- Genetic aspects, Gene therapy -- Genetic aspects, Drugs -- Genetic aspects, Cancer -- Care and treatment -- Genetic aspects -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Peptides -- Genetic aspects, Adenoviruses -- Genetic aspects, Antimitotic agents -- Genetic aspects, Biotechnology industry, Health, Science and technology
Abstract

Fresh data on cancer gene therapy are presented in the report 'Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob.' 'A conditionally [...]

Published
2009

32. Investigators at Virginia Commonwealth University publish new data on pancreatic cancer

Subjects
Virginia Commonwealth University, Oncology, Experimental -- Genetic aspects, Cancer -- Genetic aspects -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health, Care and treatment, Genetic aspects
Abstract

'The death rate for pancreatic cancer approximates the number of new cases each year, and when diagnosed, current therapeutic regimens provide little benefit in extending patient survival. These dire statistics [...]

Published
2008

33. Pancreatic cancer survival linked to DNA repair gene polymorphisms

Subjects
University of Texas. M.D. Anderson Cancer Center, Oncology, Experimental, DNA, Genetic research, Cancer -- Genetic aspects -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health, Science and technology, Care and treatment, Genetic aspects
Abstract

Pancreatic cancer survival could be linked to homologous recombination DNA repair gene polymorphisms. "Genetic variation in DNA repair may affect the clinical response to cytotoxic therapies. We investigated the effect [...]

Published
2006

34. Pancreatic cancer survival linked to DNA repair gene polymorphisms

Subjects
University of Texas. M.D. Anderson Cancer Center, Oncology, Experimental, DNA, Genetic research, Cancer -- Genetic aspects -- Research, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health, Care and treatment, Genetic aspects
Abstract

Pancreatic cancer survival could be linked to homologous recombination DNA repair gene polymorphisms. "Genetic variation in DNA repair may affect the clinical response to cytotoxic therapies. We investigated the effect [...]

Published
2006

35. 5-fluorouracil and gemcitabine enhance gene therapy in pancreatic cancer

Subjects
Genetic research -- Genetic aspects, Fluorouracil -- Genetic aspects, Gene therapy -- Genetic aspects, Cancer -- Genetic aspects -- Care and treatment, Pancreatic cancer -- Care and treatment -- Genetic aspects, Health, Memorial Sloan-Kettering Cancer Center
Abstract

According to recent research from the United States, 5-fluorouracil (5-FU) and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. 'Oncolytic herpes viruses [...]

Published
2006

36. Pancreatic cancer trial opens using tumor-targeted gene therapy vector

Subjects
Care and treatment, Genetic aspects, Product development, Cancer treatment -- Genetic aspects, Clinical trials -- Genetic aspects, Cancer genetics -- Care and treatment -- Genetic aspects, Genetic research -- Genetic aspects, Gene therapy -- Genetic aspects, Pancreatic cancer -- Care and treatment -- Genetic aspects, Biotechnology industries -- Product development -- Genetic aspects, Cancer metastasis -- Care and treatment -- Genetic aspects, Metastasis -- Care and treatment -- Genetic aspects, Biotechnology industry -- Product development -- Genetic aspects, Cancer -- Care and treatment -- Genetic aspects
Abstract

Epeius Biotechnologies Corp. announced that a phase I clinical trial has opened at Mayo Clinic Cancer Center, Rochester, Minnesota to test the safety of Rexin-G, the first tumor-targeted gene therapy [...]

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results