663 results on '"Pancheri P"'
Search Results
2. First results on monolithic CMOS detector with internal gain
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Follo, U., Gioachin, G., Ferrero, C., Mandurrino, M., Bregant, M., Bufalino, S., Carnesecchi, F., Cavazza, D., Colocci, M., Corradino, T., Rolo, M. Da Rocha, Di Nicolantonio, G., Durando, S., Margutti, G., Mignone, M., Nania, R., Pancheri, L., Rivetti, A., Sabiu, B., de Souza, G. G. A., Strazzi, S., and Wheadon, R.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
In this paper we report on a set of characterisations carried out on the first monolithic LGAD prototype integrated in a customised 110 nm CMOS process having a depleted active volume thickness of 48 $\mu$m. This prototype is formed by a pixel array where each pixel has a total size of 100 $\mu$m $\times$ 250 $\mu$m and includes a high-speed front-end amplifier. After describing the sensor and the electronics architecture, both laboratory and in-beam measurements are reported and described. Optical characterisations performed with an IR pulsed laser setup have shown a sensor internal gain of about 2.5. With the same experimental setup, the electronic jitter was found to be between 50 ps and 150 ps, depending on the signal amplitude. Moreover, the analysis of a test beam performed at the Proton Synchrotron (PS) T10 facility of CERN with 10 GeV/c protons and pions indicated that the overall detector time resolution is in the range of 234 ps to 244 ps. Further TCAD investigations, based on the doping profile extracted from $C(V)$ measurements, confirmed the multiplication gain measured on the test devices. Finally, TCAD simulations were used to tune the future doping concentration of the gain layer implant, targeting sensors with a higher avalanche gain. This adjustment is expected to enhance the timing performance of the sensors of the future productions, in order to cope with the high event rate expected in most of the near future high-energy and high-luminosity physics experiments, where the time resolution will be essential to disentangle overlapping events and it will also be crucial for Particle IDentification (PID).
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- 2024
3. Raoul Gatto and Bruno Touschek's joint legacy in the rise of electron-positron physics
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Bonolis, Luisa, Buccella, Franco, and Pancheri, Giulia
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Physics - History and Philosophy of Physics ,High Energy Physics - Phenomenology - Abstract
Raoul Gatto and Bruno Touschek's collaboration in the establishment of electron positron colliders as a fundamental discovery tool in particle physics will be illustrated. In particular, we will tell the little-known story of how Gatto and Touschek's pioneering vision combined to provide the theoretical foundations for AdA, the first matter-antimatter collider, and how their friendship with Wolfgang Pauli and Gerhard L\"uders was crucial to their understanding of the CPT theorem, the basis for AdA's success. We will see how these two exceptional scientists shaped physics between Rome and Frascati, from the proposal to build AdA and, soon after in 1961, the larger machine ADONE, to the discovery of the $J/\Psi$ particle in 1974. We will also highlight Gatto and Touschek's contribution in mentoring an extraordinary cohort of students and collaborators whose work contributed to the renaissance of Italian theoretical physics after the Second World War and to the establishment of the Standard Model of particle physics., Comment: 69 pages, 29 figures, 3 appendices, doubling the previous version in number of pages, many more figures and added bibliography, enlarging version1 to incorporate Gatto and Touschek's legacy beyond AdA with extra sections about ADONE, the development of the Frascati Laboratory theory group, the appearance of multihadron production and the confirmation of the American discovery of the J/Psi
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- 2023
4. Coronary Sinus Thrombosis and Post-Myocardial Infarction Syndrome in Kawasaki Disease Rare Causes of Pericardial Effusion
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Wang, Hao, Pancheri, Joan M, Appleton, Robert S, Tremoulet, Adriana H, Burns, Jane C, and Dummer, Kirsten B
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Epidemiology ,Health Sciences ,Heart Disease ,Autoimmune Disease ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Hematology ,Rare Diseases ,Dressler syndrome ,Kawasaki disease ,coronary sinus thrombosis ,pericardial effusion ,post-myocardial infarction syndrome - Abstract
The hypercoagulable state in Kawasaki disease (KD) may lead to complex cardiovascular sequelae. We present the case of a 2-month-old infant with complete KD complicated by giant coronary artery aneurysms, coronary sinus thrombosis, and post-myocardial infarction syndrome (Dressler syndrome), resulting in 2 distinct episodes of pericardial effusion. (Level of Difficulty: Intermediate.).
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- 2023
5. Subgroups of children with Kawasaki disease: a data-driven cluster analysis.
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Wang, Hao, Shimizu, Chisato, Bainto, Emelia, Hamilton, Shea, Jackson, Heather, Estrada-Rivadeneyra, Diego, Kaforou, Myrsini, Levin, Michael, Pancheri, Joan, Dummer, Kirsten, Tremoulet, Adriana, and Burns, Jane
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United States ,Humans ,Child ,Mucocutaneous Lymph Node Syndrome ,Immunoglobulins ,Intravenous ,Proteomics ,Cluster Analysis ,Aneurysm - Abstract
BACKGROUND: Although Kawasaki disease is commonly regarded as a single disease entity, variability in clinical manifestations and disease outcome has been recognised. We aimed to use a data-driven approach to identify clinical subgroups. METHODS: We analysed clinical data from patients with Kawasaki disease diagnosed at Rady Childrens Hospital (San Diego, CA, USA) between Jan 1, 2002, and June 30, 2022. Patients were grouped by hierarchical clustering on principal components with k-means parcellation based on 14 variables, including age at onset, ten laboratory test results, day of illness at the first intravenous immunoglobulin infusion, and normalised echocardiographic measures of coronary artery diameters at diagnosis. We also analysed the seasonality and Kawasaki disease incidence from 2002 to 2019 by subgroup. To explore the biological underpinnings of identified subgroups, we did differential abundance analysis on proteomic data of 6481 proteins from 32 patients with Kawasaki disease and 24 healthy children, using linear regression models that controlled for age and sex. FINDINGS: Among 1016 patients with complete data in the final analysis, four subgroups were identified with distinct clinical features: (1) hepatobiliary involvement with elevated alanine transaminase, gamma-glutamyl transferase, and total bilirubin levels, lowest coronary artery aneurysm but highest intravenous immunoglobulin resistance rates (n=157); (2) highest band neutrophil count and Kawasaki disease shock rate (n=231); (3) cervical lymphadenopathy with high markers of inflammation (erythrocyte sedimentation rate, C-reactive protein, white blood cell, and platelet counts) and lowest age-adjusted haemoglobin Z scores (n=315); and (4) young age at onset with highest coronary artery aneurysm but lowest intravenous immunoglobulin resistance rates (n=313). The subgroups had distinct seasonal and incidence trajectories. In addition, the subgroups shared 211 differential abundance proteins while many proteins were unique to a subgroup. INTERPRETATION: Our data-driven analysis provides insight into the heterogeneity of Kawasaki disease, and supports the existence of distinct subgroups with important implications for clinical management and research design and interpretation. FUNDING: US National Institutes of Health and the Irving and Francine Suknow Foundation.
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- 2023
6. Design of a spider-inspired wheeled compliant leg for search mobile robots
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Yilin Wang, Felix Pancheri, Tim C. Lueth, and Yilun Sun
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Compliant leg ,Semi-tendon-driven mechanism ,Biomimetic design ,Search mobile robot ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Earthquake and other disasters nowadays still threat people’s lives and property due to their destructiveness and unpredictability. The past decades have seen the booming development of search and rescue robots due to their potential for increasing rescue capacity as well as reducing personnel safety risk at disaster sites. In this work, we propose a spider-inspired wheeled compliant leg to further improve the environmental adaptability of search mobile robots. Different from the traditional fully-actuated method with independent motor joint control, this leg employs an under-actuated compliant mechanism design with overall semi-tendon-driven control, which enables the passive and active terrain adaptation, system simplification and lightweight of the realized search robot. We have generalized the theoretical model and design methodology for this type of compliant leg, and implement it in a parametric program to improve the design efficiency. In addition, preliminary load capacity and leg-lifting experiments are carried out on a one-leg prototype to evaluate its mechanical performance. A four-legged robot platform is also fabricated for the locomotion tests. The preliminary experimental results have verified the feasibility of the proposed design methodology, and also show possibilities for improvements. In future work, structural optimization and stronger actuation elements should be introduced to further improve the mechanical performance of the fabricated wheeled leg mechanism and robot platform.
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- 2024
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7. High-Precision 4D Tracking with Large Pixels using Thin Resistive Silicon Detectors
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Arcidiacono, R., Borghi, G., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Costa, M., Betta, G-F. Dalla, Ferrero, M., Ficorella, F., Gioachin, G., Lanteri, L., Mandurrino, M., Menzio, L., Mulargia, R., Pancheri, L., Paternoster, G., Rojas, A., Sadrozinski, H-F W., Seiden, A., Siviero, F., Sola, V., and Tornago, M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The basic principle of operation of silicon sensors with resistive read-out is built-in charge sharing. Resistive Silicon Detectors (RSD, also known as AC-LGAD), exploiting the signals seen on the electrodes surrounding the impact point, achieve excellent space and time resolutions even with very large pixels. In this paper, a TCT system using a 1064 nm picosecond laser is used to characterize sensors from the second RSD production at the Fondazione Bruno Kessler. The paper first introduces the parametrization of the errors in the determination of the position and time coordinates in RSD, then outlines the reconstruction method, and finally presents the results. Three different pixel sizes are used in the analysis: 200 x 340, 450 x 450, and 1300 x 1300 microns^2. At gain = 30, the 450 x 450 microns^2 pixel achieves a time jitter of 20 ps and a spatial resolution of 15 microns concurrently, while the 1300 x 1300 microns^2 pixel achieves 30 ps and 30 micron, respectively. The implementation of cross-shaped electrodes improves considerably the response uniformity over the pixel surface., Comment: 28 pages, 23 figures submitted to NIMA
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- 2022
8. Beam test results of 25 $\mu$m and 35 $\mu$m thick FBK UFSD]{Beam test results of 25 $\mu$m and 35 $\mu$m thick FBK ultra fast silicon detectors
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Carnesecchi, F., Strazzi, S., Alici, A., Arcidiacono, R., Borghi, G., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Cavazza, D., Betta, G. -F. Dalla, Durando, S., Ferrero, M., Ficorella, F., Ali, O. Hammad, Mandurrino, M., Margotti, A., Menzio, L., Nania, R., Pancheri, L., Paternoster, G., Scioli, G., Siviero, F., Sola, V., Tornago, M., and Vignola, G.
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Physics - Instrumentation and Detectors - Abstract
This paper presents the measurements on first very thin Ultra Fast Silicon Detectors (UFSDs) produced by Fondazione Bruno Kessler; the data have been collected in a beam test setup at the CERN PS, using beam with a momentum of 12 GeV/c. UFSDs with a nominal thickness of 25 $\mu$m and 35 $\mu$m and an area of 1 $\times$ 1 $\text{mm}^2$ have been considered, together with an additional HPK 50-$\mu$m thick sensor, taken as reference. Their timing performances have been studied as a function of the applied voltage and gain. A time resolution of about 25 ps and of 22 ps at a voltage of 120 V and 240 V has been obtained for the 25 and 35 $\mu$m thick UFSDs, respectively.
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- 2022
9. DC-coupled resistive silicon detectors for 4-D tracking
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Menzio, L., Arcidiacono, R., Borghi, G., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Costa, M., Betta, G-F. Dalla, Ferrero, M., Ficorella, F., Gioachin, G., Mandurrino, M., Pancheri, L., Paternoster, G., Siviero, F., Sola, V., and Tornago, M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Physics - Computational Physics - Abstract
In this work, we introduce a new design concept: the DC-Coupled Resistive Silicon Detectors, based on the LGAD technology. This new approach intends to address a few known features of the first generation of AC-Coupled Resistive Silicon Detectors (RSD). Our simulation exploits a fast hybrid approach based on a combination of two packages, Weightfield2 and LTSpice. It demonstrates that the key features of the RSD design are maintained, yielding excellent timing and spatial resolutions: a few tens of ps and a few microns. In the presentation, we will outline the optimization methodology and the results of the simulation. We will present detailed studies on the effect of changing the ratio between the n+ layer resistivity and the low-resistivity ring and on the achievable temporal and spatial resolution.
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- 2022
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10. Tuning of gain layer doping concentration and Carbon implantation effect on deep gain layer
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Mazza, S. M., Gee, C., Zhao, Y., Padilla, R., Ryan, E., Tournebise, N., Darby, B., McKinney-Martinez, F., Sadrozinski, H. F. -W., Seiden, A., Schumm, B., Cindro, V., Kramberger, G., Mandić, I., Mikuž, M., Zavrtanik, M., Arcidiacono, R., Cartiglia, N., Ferrero, M., Mandurrino, M., Sola, V., Staiano, A., Boscardin, M., Della Betta, G. F., Ficorella, F., Pancheri, L., and Paternoster, G.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Next generation Low Gain Avalanche Diodes (LGAD) produced by Hamamatsu photonics (HPK) and Fondazione Bruno Kessler (FBK) were tested before and after irradiation with ~1MeV neutrons at the JSI facility in Ljubljana. Sensors were irradiated to a maximum 1-MeV equivalent fluence of 2.5E15 Neq/cm2. The sensors analysed in this paper are an improvement after the lessons learned from previous FBK and HPK productions that were already reported in precedent papers. The gain layer of HPK sensors was fine-tuned to optimize the performance before and after irradiation. FBK sensors instead combined the benefit of Carbon infusion and deep gain layer to further the radiation hardness of the sensors and reduced the bulk thickness to enhance the timing resolution. The sensor performance was measured in charge collection studies using \b{eta}-particles from a 90Sr source and in capacitance-voltage scans (C-V) to determine the bias to deplete the gain layer. The collected charge and the timing resolution were measured as a function of bias voltage at -30C. Finally a correlation is shown between the bias voltage to deplete the gain layer and the bias voltage needed to reach a certain amount of gain in the sensor. HPK sensors showed a better performance before irradiation while maintaining the radiation hardness of the previous production. FBK sensors showed exceptional radiation hardness allowing a collected charge up to 10 fC and a time resolution of 40 ps at the maximum fluence., Comment: arXiv admin note: text overlap with arXiv:2004.05260
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- 2022
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11. Optimization of the Gain Layer Design of Ultra-Fast Silicon Detectors
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Siviero, Federico, Arcidiacono, Roberta, Borghi, Giacomo, Boscardin, Maurizio, Cartiglia, Nicolo, Vignali, Matteo Centis, Costa, Marco, Betta, Gian Franco Dalla, Ferrero, Marco, Ficorella, Francesco, Gioachin, Giulia, Mandurrino, Marco, Mazza, Simone, Menzio, Luca, Pancheri, Lucio, Paternoster, Giovanni, Sadrozinski, Hartmut F. W., Seiden, Abraham, Sola, Valentina, and Tornago, Marta
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
In the past few years, the need of measuring accurately the spatial and temporal coordinates of the particles generated in high-energy physics experiments has spurred a strong R\&D in the field of silicon sensors. Within these research activities, the so-called Ultra-Fast Silicon Detectors (UFSDs), silicon sensors optimized for timing based on the Low-Gain Avalanche Diode (LGAD) design, have been proposed and adopted by the CMS and ATLAS collaborations for their respective timing layers. The defining feature of the Ultra-Fast Silicon Detectors (UFSDs) is the internal multiplication mechanism, determined by the gain layer design. In this paper, the performances of several types of gain layers, measured with a telescope instrumented with a $^{90}$Sr $\beta$-source, are reported and compared. The measured sensors are produced by Fondazione Bruno Kessler (FBK) and Hamamatsu Photonics (HPK). The sensor yielding the best performance, both when new and irradiated, is an FBK 45\mum-thick sensor with a carbonated deep gain implant, where the carbon and the boron implants are annealed concurrently with a low thermal load. This sensor is able to achieve a time resolution of 40~ps up to a radiation fluence of~\fluence{2.5}{15}, delivering at least 5~fC of charge., Comment: v3 revised version as requested by Editor
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- 2021
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12. The second production of RSD (AC-LGAD) at FBK
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Mandurrino, M., Arcidiacono, R., Bisht, A., Borghi, G., Boscardin, M., Cartiglia, N., Vignali, M. Centis, Betta, G. -F. Dalla, Ferrero, M., Ficorella, F., Ali, O. Hammad, Rojas, A. D. Martinez, Menzio, L., Pancheri, L., Paternoster, G., Siviero, F., Sola, V., and Tornago, M.
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Physics - Instrumentation and Detectors - Abstract
In this contribution we describe the second run of RSD (Resistive AC-Coupled Silicon Detectors) designed at INFN Torino and produced by Fondazione Bruno Kessler (FBK), Trento. RSD are n-in-p detectors intended for 4D particle tracking based on the LGAD technology that get rid of any segmentation implant in order to achieve the 100% fill-factor. They are characterized by three key-elements, (i) a continuous gain implant, (ii) a resistive n-cathode and (iii) a dielectric coupling layer deposited on top, guaranteeing a good spatial reconstruction of the hit position while benefiting from the good timing properties of LGADs. We will start from the very promising results of our RSD1 batch in terms of tracking performances and then we will move to the description of the design of the RSD2 run. In particular, the principles driving the sensor design and the specific AC-electrode layout adopted to optimize the signal confinement will be addressed.
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- 2021
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13. Inter-pad dead regions of irradiated FBK Low Gain Avalanche Detectors
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Darby, B., Mazza, S. M., McKinney-Martinez, F., Padilla, R., Sadrozinski, H. F. -W., Seiden, A., Schumm, B., Wilder, M., Zhao, Y., Arcidiacono, R., Cartiglia, N., Ferrero, M., Mandurrino, M., Sola, V., Staiano, A., Cindro, V., Kranberger, G., Mandiz, I., Mikuz, M., Zavtranik, M., Boscardin, M., Della Betta, G. F., Ficorella, F., Pancheri, L., and Paternoster, G.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Low Gain Avalanche Detectors (LGADs) are a type of thin silicon detector with a highly doped gain layer. LGADs manufactured by Fondazione Bruno Kessler (FBK) were tested before and after irradiation with neutrons. In this study, the Inter-pad distances (IPDs), defined as the width of the distances between pads, were measured with a TCT laser system. The response of the laser was tuned using $\beta$-particles from a 90Sr source. These insensitive "dead zones" are created by a protection structure to avoid breakdown, the Junction Termination Extension (JTE), which separates the pads. The effect of neutron radiation damage at \fluence{1.5}{15}, and \fluence{2.5}{15} on IPDs was studied. These distances are compared to the nominal distances given from the vendor, it was found that the higher fluence corresponds to a better matching of the nominal IPD.
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- 2021
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14. Core competencies in palliative care among oncology nurses: An observational study
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Elisa Abbadini, Ilaria Basile, Francesco Abbadini, Maria Luisa Pancheri, and Letteria Consolo
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Palliative care ,Professional Competence ,Nursing Care ,Self-Assessment ,Nurses ,Nursing ,RT1-120 - Abstract
BACKGROUND: Palliative care requires a collaborative approach from a multidisciplinary team, incorporating nurses with ethical, clinical, communicative-relational, psychosocial, and teamwork skills. However, many professionals feel unprepared to face end-of-life challenges, highlighting a lack of skills, especially regarding psychosocial and spiritual aspects. AIM: The purpose of this study is to explore nurses' self-perception of competencies in palliative care. METHODS: A single-center descriptive observational study was conducted among palliative and non-palliative care nurses at the Fondazione IRCCS Istituto Nazionale dei Tumori in Milan (INT), using the short Italian version of the Professional Competence Scale (PCSQ). The Kruskal-Wallis test was used along with multivariate ANOVA for statistical analysis. RESULTS: 122 nurses participated (response rate: 52%), predominantly women (78%), aged 25-34 (50%), with a degree (46%) and over 10 years of experience (41%). The majority had no experience (71%) in palliative care, while 16% were currently working in this field. Statistical analysis revealed no significant correlations between educational level and responses. The Kruskal-Wallis test showed that experience in palliative care significantly influenced self-assessment scores, such as in activating non-pharmacological management strategies (p=0.004). CONCLUSIONS: Nurses perceive high competence in ethical and clinical decision-making in palliative care, influenced more by experience than by training. Addressing patients' subjective needs and using non-pharmacological interventions remain a challenge for nurses not working in palliative care settings.
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- 2024
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15. Fully Depleted Monolithic Active Microstrip Sensors: TCAD simulation study of an innovative design concept
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De Cilladi, Lorenzo, Corradino, Thomas, Betta, Gian-Franco Dalla, Neubüser, Coralie, and Pancheri, Lucio
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Physics - Instrumentation and Detectors - Abstract
The paper presents the simulation studies of 10 $\mu$m pitch microstrips on a fully depleted monolithic active CMOS technology and describes their potential to provide a new and cost-effective solution for particle tracking and timing applications. The Fully Depleted Monolithic Active Microstrip Sensors (FD-MAMS) described in this work, which are developed within the framework of the ARCADIA project, are compliant with commercial CMOS fabrication processes. A TCAD simulation campaign was performed in the perspective of an upcoming engineering production run with the aim of designing FD-MAMS, studying their electrical characteristics and optimising the sensor layout for enhanced performance in terms of low capacitance, fast charge collection and low-power operation. A very fine pitch of 10 $\mu$m was chosen to provide very high spatial resolution. This small pitch still allows readout electronics to be monolithically integrated in the inter-strip regions, enabling the segmentation of long strips and the implementation of distributed readout architectures. The effects of surface radiation damage expected for total ionising doses of the order of 10 to 10$^5$ krad were also modelled in the simulations. The results of the simulations exhibit promising performance in terms of timing and low power consumption and motivate R&D efforts to further develop FD-MAMS; the results will be experimentally verified through measurements on the test structures that will be available at the beginning of 2021., Comment: 26 pages, 26 figures, submitted to MDPI Sensors
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- 2021
16. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trialResearch in context
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Giovanni Ostuzzi, Chiara Gastaldon, Mauro Tettamanti, Massimo Cartabia, Igor Monti, Andrea Aguglia, Eugenio Aguglia, Francesco Bartoli, Camilla Callegari, Andrea Canozzi, Elvira Anna Carbone, Giuseppe Carrà, Rosangela Caruso, Simone Cavallotti, Stefania Chiappini, Fabrizio Colasante, Beatrice Compri, Armando D'Agostino, Pasquale De Fazio, Renato de Filippis, Matteo Gari, Marta Ielmini, Gianmarco Ingrosso, Silvia Mammarella, Giovanni Martinotti, Alessandro Rodolico, Rita Roncone, Enrico Sterzi, Lorenzo Tarsitani, Elisa Tiberto, Liliana Todini, Francesco Amaddeo, Barbara D'Avanzo, Angelo Barbato, Corrado Barbui, Maria Chiara Alessi, Gabriele Avincola, Bianca Bachi, Gianna Bernasconi, Andrea Birgillito, Emanuele Bisso, Stefano Bonora, Angela Calabrese, Tommaso Callovini, Aurelia Canestro, Salvo Canonico, Chiara Alessandro Capogrosso, Elvira Carbone, Doriana Carosielli, Ivano Caselli, Daniele Cavaleri, Clara Cavallotto, Marco Cesca, Cecilia Chiarenza, Riccardo Matteo Cioni, Sara Coloccini, Marco Cruciata, Claudia Cumerlato, Renato De Filippis, Manuela De Palma, Sasha Del Vecchio, Bianca Della Rocca, Chiara Di Natale, Ettore D'Onofrio, Irene Espa, Giulia Fior, Marta Gancitano, Barbara Giordano, Laura Giusti, Luigi Grassi, Pierluca Guzzi, Celeste Isella, Annamaria Lax, Leonardo Marano, Federico Marconi, Marco Marella, Alessia Metelli, Giulia Michencig, Andrea Miuli, Alessandro Moncada, Pietro Morello, Federico Moretti, Marco Morreale, Alessio Mosca, Christian Nasti, Michela Nosé, Filippo Ogheri, Margherita Oresti, Alessandra Ornaghi, Dario Palpella, Corinna Pancheri, Davide Papola, Silvia Passeri, Mauro Pettorusso, Susanna Piacenti, Irene Pinucci, Valentina Pugliese, Marianna Purgato, Marianna Rania, Federica Robbi, Samantha Romito, Barbara Ronchi, Valentina Roselli, Cristina Segura-Garcia, Maria Salvina Signorelli, Gabriele Simonelli, Antonella Sociali, Serena Sturiale, Antonio Tambelli, Beatrice Todesco, Alice Trabucco, Giulia Turrini, Veronica Villa, Federico Wiedenmann, Luca Zambuto, Elisa Zanini, Chiara Zannini, and Luigi Zerbinati
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Older adults ,Major depressive disorder ,Vortioxetine ,Serotonin selective reuptake inhibitors ,Tolerability ,Adverse events ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Major depressive disorder (MDD) is prevalent and disabling among older adults. Standing on its tolerability profile, vortioxetine might be a promising alternative to selective serotonin reuptake inhibitors (SSRIs) in such a vulnerable population. Methods: We conducted a randomised, assessor- and statistician-blinded, superiority trial including older adults with MDD. The study was conducted between 02/02/2019 and 02/22/2023 in 11 Italian Psychiatric Services. Participants were randomised to vortioxetine or one of the SSRIs, selected according to common practice. Treatment discontinuation due to adverse events after six months was the primary outcome, for which we aimed to detect a 12% difference in favour of vortioxetine. The study was registered in the online repository clinicaltrials.gov (NCT03779789). Findings: The intention-to-treat population included 179 individuals randomised to vortioxetine and 178 to SSRIs. Mean age was 73.7 years (standard deviation 6.1), and 264 participants (69%) were female. Of those on vortioxetine, 78 (44%) discontinued the treatment due to adverse events at six months, compared to 59 (33%) of those on SSRIs (odds ratio 1.56; 95% confidence interval 1.01–2.39). Adjusted and per-protocol analyses confirmed point estimates in favour of SSRIs, but without a significant difference. With the exception of the unadjusted survival analysis showing SSRIs to outperform vortioxetine, secondary outcomes provided results consistent with a lack of substantial safety and tolerability differences between the two arms. Overall, no significant differences emerged in terms of response rates, depressive symptoms and quality of life, while SSRIs outperformed vortioxetine in terms of cognitive performance. Interpretation: As opposed to what was previously hypothesised, vortioxetine did not show a better tolerability profile compared to SSRIs in older adults with MDD in this study. Additionally, hypothetical advantages of vortioxetine on depression-related cognitive symptoms might be questioned. The study's statistical power and highly pragmatic design allow for generalisability to real-world practice. Funding: The study was funded by the Italian Medicines Agency within the “2016 Call for Independent Drug Research”.
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- 2024
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17. Sensor design optimization of innovative low-power, large area MAPS for HEP and applied science
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Neubüser, Coralie, Corradino, Thomas, Betta, Gian-Franco Dalla, De Cilladi, Lorenzo, and Pancheri, Lucio
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Physics - Instrumentation and Detectors - Abstract
Fully Depleted Monolithic Active Pixels (FD-MAPS) represent a state-of-the-art detector technology and profit from a low material budget and cost for high energy physics experiments and other fields of research like medical imaging and astro-particle physics. Compared to the MAPS currently in use, fully depleted pixel sensors have the advantage of charge collection by drift, which enables a fast and uniform response overall the pixel matrix. The functionality of these devices has been shown in previous proof-of-concept productions. In this article we describe the optimization of the test pixel designs, that will be implemented in the first engineering run of the demonstrator chip of the ARCADIA project. These optimization procedures include radiation damage models, that have been employed in Technology Computer Aided Design simulations to predict the sensors behavior in different working environments., Comment: 16 pages, 13 figures, submitted to Frontiers in Physics
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- 2020
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18. About soft photon resummation
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Pancheri, Giulia and Srivastava, Yogendra N.
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Physics - History and Philosophy of Physics ,High Energy Physics - Phenomenology - Abstract
The first time one of us (G.P.) encountered Earle was in Summer 1966, when she was directed to study Earle's papers on radiative corrections to quasi-elastic electron scattering. The suggestion had come from Bruno Touschek, at the time head of the theoretical physics group at the Frascati National Laboratories near Rome. About the same time, Earle came from MIT to visit University of Rome and Frascati. G.P. was a young post-graduate, who had studied Earle's papers and was awed by his already impressive scientific figure. After almost 40 years had passed, Earle visited Italy with his wife Ruth, making Frascati their base for an extended visit of almost a month. They were housed in what was then the laboratory hostel for foreign visitors, a small villa higher up above the hill, toward the town of Frascati. Since then, we became close friends, a friendship which included both his family and ours, and which has been very important for us. In memory of that first visit and in gratitude for the many years of friendship, we will tell here a story of infrared radiative corrections to charged particle scattering, to which Earle's papers gave an important contribution., Comment: A contribution to Earle Lomon's 90th birthday celebration, 8 pages
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- 2020
19. Resistive AC-Coupled Silicon Detectors: principles of operation and first results from a combined analysis of beam test and laser data
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Tornago, M., Arcidiacono, R., Cartiglia, N., Costa, M., Ferrero, M., Mandurrino, M., Siviero, F., Sola, V., Staiano, A., Apresyan, A., Di Petrillo, K., Heller, R., Los, S., Borghi, G., Boscardin, M., Betta, G-F Dalla, Ficorella, F., Pancheri, L., Paternoster, G., Sadrozinski, H., and Seiden, A.
- Subjects
Physics - Instrumentation and Detectors - Abstract
This paper presents the principles of operation of Resistive AC-Coupled Silicon Detectors (RSDs) and measurements of the temporal and spatial resolutions using a combined analysis of laser and beam test data. RSDs are a new type of n-in-p silicon sensor based on the Low-Gain Avalanche Diode (LGAD) technology, where the $n^+$ implant has been designed to be resistive, and the read-out is obtained via AC-coupling. The truly innovative feature of RSD is that the signal generated by an impinging particle is shared isotropically among multiple read-out pads without the need for floating electrodes or an external magnetic field. Careful tuning of the coupling oxide thickness and the $n^+$ doping profile is at the basis of the successful functioning of this device. Several RSD matrices with different pad width-pitch geometries have been extensively tested with a laser setup in the Laboratory for Innovative Silicon Sensors in Torino, while a smaller set of devices have been tested at the Fermilab Test Beam Facility with a 120 GeV/c proton beam. The measured spatial resolution ranges between $2.5\; \mu m$ for 70-100 pad-pitch geometry and $17\; \mu m$ with 200-500 matrices, a factor of 10 better than what is achievable in binary read-out ($bin\; size/ \sqrt{12}$). Beam test data show a temporal resolution of $\sim 40\; ps$ for 200-$\mu m$ pitch devices, in line with the best performances of LGAD sensors at the same gain., Comment: 34 pages, 33 figures
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- 2020
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20. Bruno Touschek in Glasgow. The making of a theoretical physicist
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Pancheri, Giulia and Bonolis, Luisa
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Physics - History and Philosophy of Physics ,High Energy Physics - Phenomenology ,Physics - Accelerator Physics - Abstract
In the history of the discovery tools of last century particle physics, central stage is taken by elementary particle accelerators and in particular by colliders. In their start and early development, a major role was played by the Austrian born Bruno Touschek, who proposed and built the first electron positron collider, AdA, in Italy, in 1960. In this note, we present a period of Touschek's life barely explored in the literature, namely the five years he spent at University of Glasgow, first to obtain his doctorate in 1949 and then as a lecturer. We shall highlight his formation as a theoretical physicist, his contacts and correspondence with Werner Heisenberg in G\"ottingen and Max Born in Edinburgh, as well as his close involvement with colleagues intent on building modern particle accelerators in Glasgow, Malvern, Manchester and Birmingham. We shall discuss how the Fuchs affair, which unraveled in early 1950, may have influenced his decision to leave the UK, and how contacts with the Italian physicist Bruno Ferretti led Touschek to join the Guglielmo Marconi Physics Institute of University of Rome in January 1953., Comment: 67 pages, 29 figures
- Published
- 2020
21. High performance picosecond- and micron-level 4D particle tracking with 100% fill-factor Resistive AC-Coupled Silicon Detectors (RSD)
- Author
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Mandurrino, M., Cartiglia, N., Tornago, M., Ferrero, M., Siviero, F., Paternoster, G., Ficorella, F., Boscardin, M., Pancheri, L., and Betta, G. F. Dalla
- Subjects
Physics - Instrumentation and Detectors - Abstract
In this paper we present a complete characterization of the first batch of Resistive AC-Coupled Silicon Detectors, called RSD1, designed at INFN Torino and manufactured by Fondazione Bruno Kessler (FBK) in Trento. With their 100% fill-factor, RSD represent the new enabling technology for high-precision 4D-tracking. Indeed, being based on the well-known charge multiplication mechanism of Low-Gain Avalanche Detectors (LGAD), they benefit from the very good timing performances of such technology together with an unprecedented resolution of the spatial tracking, which allows to reach the micron-level scale in the track reconstruction. This is essentially due to the absence of any segmentation structure between pads (100% fill-factor) and to other two innovative key-features: the first one is a properly doped n+ resistive layer, slowing down the charges just after being multiplied, and the second one is a dielectric layer grown on Silicon, inducing a capacitive coupling on the metal pads deposited on top of the detector. The very good spatial resolution (micron-level) we measured experimentally - higher than the nominal pad pitch - comes from the analogical nature of the readout of signals, whose amplitude attenuates from the pad center to its periphery, while the outstanding results in terms of timing (less than 14 ps, even better than standard LGAD) are due to a combination of very-fine pitch, analogical response and charge multiplication.
- Published
- 2020
22. Design of topology optimized compliant legs for bio-inspired quadruped robots
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Sun, Yilun, Zong, Chujun, Pancheri, Felix, Chen, Tong, and Lueth, Tim C.
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- 2023
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23. Innovative Detection of Biomarkers Based on Chemiluminescent Nanoparticles and a Lensless Optical Sensor
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Cristina Potrich, Gianluca Palmara, Francesca Frascella, Lucio Pancheri, and Lorenzo Lunelli
- Subjects
chemiluminescent detection ,lensless biosensor ,lateral flow test ,antibody-functionalized nanoparticles ,Biotechnology ,TP248.13-248.65 - Abstract
The identification and quantification of biomarkers with innovative technologies is an urgent need for the precise diagnosis and follow up of human diseases. Body fluids offer a variety of informative biomarkers, which are traditionally measured with time-consuming and expensive methods. In this context, lateral flow tests (LFTs) represent a rapid and low-cost technology with a sensitivity that is potentially improvable by chemiluminescence biosensing. Here, an LFT based on gold nanoparticles functionalized with antibodies labeled with the enzyme horseradish peroxidase is combined with a lensless biosensor. This biosensor comprises four Silicon Photomultipliers (SiPM) coupled in close proximity to the LFT strip. Microfluidics for liquid handling complete the system. The development and the setup of the biosensor is carefully described and characterized. C-reactive protein was selected as a proof-of-concept biomarker to define the limit of detection, which resulted in about 0.8 pM when gold nanoparticles were used. The rapid readout (less than 5 min) and the absence of sample preparation make this biosensor promising for the direct and fast detection of human biomarkers.
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- 2024
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24. Coronary Sinus Thrombosis and Post-Myocardial Infarction Syndrome in Kawasaki Disease
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Hao Wang, MD, MS, Joan M. Pancheri, BSN, Robert S. Appleton, MD, Adriana H. Tremoulet, MD, MAS, Jane C. Burns, MD, and Kirsten B. Dummer, MD
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coronary sinus thrombosis ,Dressler syndrome ,Kawasaki disease ,pericardial effusion ,post-myocardial infarction syndrome ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The hypercoagulable state in Kawasaki disease (KD) may lead to complex cardiovascular sequelae. We present the case of a 2-month-old infant with complete KD complicated by giant coronary artery aneurysms, coronary sinus thrombosis, and post-myocardial infarction syndrome (Dressler syndrome), resulting in 2 distinct episodes of pericardial effusion. (Level of Difficulty: Intermediate.)
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- 2023
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25. Modeling Double Parton Scattering at LHC
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Pancheri, Giulia, Grau, Agnes, Pacetti, Simone, and Srivastava, Yogendra N.
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High Energy Physics - Phenomenology - Abstract
We examine present data for double parton scattering at LHC and discuss their energy dependence from its earliest measurements at the ISR. Different models for the effective cross-section are considered and their behavior studied for a variety of selected final states. We point out that data for pp ->4 jets or pp -> quarkonium pair indicate the effective cross-section to increase with energy. We compare this set of data with different models, including one inspired by our soft gluon resummation model for the impact parameter distribution of partons., Comment: 8 pages, 2 figures, to appear in the Proceedings for LFC19: Strong dynamics for physics within and beyond the Standard Model at LHC and Future Colliders, Frascati Physics Series Vol. 69 (2019)
- Published
- 2019
26. Bruno Touschek in Germany after the War: 1945-46
- Author
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Bonolis, Luisa and Pancheri, Giulia
- Subjects
Physics - History and Philosophy of Physics ,High Energy Physics - Phenomenology ,Physics - Accelerator Physics - Abstract
Bruno Touschek was an Austrian born theoretical physicist, who proposed and built the first electron-positron collider in 1960 in the Frascati National Laboratories in Italy. In this note we reconstruct a crucial period of Bruno Touschek's life so far scarcely explored, which runs from Summer 1945 to the end of 1946. We shall describe his university studies in G\"ottingen, placing them in the context of the reconstruction of German science after 1945. The influence of Werner Heisenberg and other prominent German physicists will be highlighted. In parallel, we shall show how the decisions of the Allied powers towards restructuring science and technology in the UK after the war effort, determined Touschek's move to the University of Glasgow in 1947., Comment: 38 pages, 12 figures (11 double figures, 1 single figure)
- Published
- 2019
27. First demonstration of 200, 100, and 50 um pitch Resistive AC-Coupled Silicon Detectors (RSD) with 100% fill-factor for 4D particle tracking
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Mandurrino, M., Arcidiacono, R., Boscardin, M., Cartiglia, N., Betta, G. F. Dalla, Ferrero, M., Ficorella, F., Pancheri, L., Paternoster, G., Siviero, F., and Tornago, M.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
We designed, produced, and tested RSD (Resistive AC-Coupled Silicon Detectors) devices, an evolution of the standard LGAD (Low-Gain Avalanche Diode) technology where a resistive n-type implant and a coupling dielectric layer have been implemented. The first feature works as a resistive sheet, freezing the multiplied charges, while the second one acts as a capacitive coupling for readout pads. We succeeded in the challenging goal of obtaining very fine pitch (50, 100, and 200 um) while maintaining the signal waveforms suitable for high timing and 4D-tracking performances, as in the standard LGAD-based devices.
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- 2019
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28. Design of topology optimized compliant legs for bio-inspired quadruped robots
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Yilun Sun, Chujun Zong, Felix Pancheri, Tong Chen, and Tim C. Lueth
- Subjects
Medicine ,Science - Abstract
Abstract Robotic legs are an important component of the quadruped robot for achieving different motion gaits. Although the conventional rigid-link-based legs can generally perform robust motions, they still have the issues with poor sealing when operating in complex and liquid terrains. To cope with this problem, fully compliant legs with monolithic structure have been introduced in recent years to improve the system compactness and structural compliance of quadruped robots. In this article, we present a topology-optimization-based method to achieve efficient design of compliant robotic legs. In order to balance the structural stiffness and bending flexibility of the realized leg, a multi-objective optimization algorithm is utilized. A series of design cases are presented to illustrate the design principle and analytical procedure of the proposed method. In addition, experimental evaluation is also performed, and the results have demonstrated that, a quadruped robot with the optimized legs can successfully achieve stable and continuous straight-line walking motions.
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- 2023
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29. Demonstrating the high sensitivity of MoS2 monolayers in direct x-ray detectors
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Alberto Taffelli, Max Heyl, Matteo Favaro, Sandra Dirè, Lucio Pancheri, Emil J. W. List-Kratochvil, Alberto Quaranta, and Giovanni Ligorio
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Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
Two-dimensional transition metal dichalcogenides (TMDCs) are demonstrated to be appealing semiconductors for optoelectronic applications, thanks to their remarkable properties in the ultraviolet-visible spectral range. Interestingly, TMDCs have not yet been characterized when exposed to x rays, although they would be ideal candidates for optoelectronic applications in this spectral range. They benefit from the high cross section of the constituent heavy atoms, while keeping the absorption very low, due to the ultrathin structure of the film. This encourages the development of photodetectors based on TMDCs for several applications dealing with x rays, such as radioprotection, medical treatments, and diagnosis. Given the atomic thickness of TMDCs, they can be expected to perform well at low dose measurements with minimal perturbation of the radiation beam, which is required for in vivo applications. In this paper, the use of TMDCs as active materials for direct x-ray detection is demonstrated, using a photodetector based on a MoS2 monolayer (1L-MoS2). The detector shows a response to x rays in the range of 101–102 keV, at dose rates as low as fractions of mGy/s. The sensitivity of 1L-MoS2 reaches values in the range of 108–109 µC Gy−1 cm−3, overcoming the values reported for most of the organic and inorganic materials. To improve the x-ray photoresponse even further, the 1L-MoS2 was coupled with a polymeric film integrating a scintillator based on terbium-doped gadolinium oxysulfide (Gd2O2S:Tb). The resulting signal was three times larger, enabled by the indirect x ray to visible photoconversion mechanism. This paper might pave the way toward the production of ultrathin real-time dosimeters for in vivo applications.
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- 2023
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30. Preliminary Characterization of an Active CMOS Pad Detector for Tracking and Dosimetry in HDR Brachytherapy
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Thi Ngoc Hang Bui, Matthew Large, Joel Poder, Joseph Bucci, Edoardo Bianco, Raffaele Aaron Giampaolo, Angelo Rivetti, Manuel Da Rocha Rolo, Zeljko Pastuovic, Thomas Corradino, Lucio Pancheri, and Marco Petasecca
- Subjects
brachytherapy ,CMOS ,source tracking ,active pixel ,dosimetry ,IBIC ,Chemical technology ,TP1-1185 - Abstract
We assessed the accuracy of a prototype radiation detector with a built in CMOS amplifier for use in dosimetry for high dose rate brachytherapy. The detectors were fabricated on two substrates of epitaxial high resistivity silicon. The radiation detection performance of prototypes has been tested by ion beam induced charge (IBIC) microscopy using a 5.5 MeV alpha particle microbeam. We also carried out the HDR Ir-192 radiation source tracking at different depths and angular dose dependence in a water equivalent phantom. The detectors show sensitivities spanning from (5.8 ± 0.021) × 10−8 to (3.6 ± 0.14) × 10−8 nC Gy−1 mCi−1 mm−2. The depth variation of the dose is within 5% with that calculated by TG-43. Higher discrepancies are recorded for 2 mm and 7 mm depths due to the scattering of secondary particles and the perturbation of the radiation field induced in the ceramic/golden package. Dwell positions and dwell time are reconstructed within ±1 mm and 20 ms, respectively. The prototype detectors provide an unprecedented sensitivity thanks to its monolithic amplification stage. Future investigation of this technology will include the optimisation of the packaging technique.
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- 2024
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31. Aberrant Cerebello-Cerebral Connectivity in Remitted Bipolar Patients 1 and 2: New Insight into Understanding the Cerebellar Role in Mania and Hypomania
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Olivito, Giusy, Lupo, Michela, Gragnani, Andrea, Saettoni, Marco, Siciliano, Libera, Pancheri, Corinna, Panfili, Matteo, Cercignani, Mara, Bozzali, Marco, Chiaie, Roberto Delle, and Leggio, Maria
- Published
- 2022
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32. Touschek with AdA in Orsay and the first direct observation of electron-positron collisions
- Author
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Pancheri, Giulia and Bonolis, Luisa
- Subjects
Physics - History and Philosophy of Physics ,High Energy Physics - Phenomenology ,Physics - Accelerator Physics - Abstract
We describe how the first direct observation of electron-positron collisions took place in 1963-1964 at the Laboratoire de l'Acc\'el\'erateur Lin\'eaire d'Orsay, in France, with the storage ring AdA, which had been proposed and constructed in the Italian National Laboratories of Frascati in 1960, under the guidance of Bruno Touschek. The obstacles and successes of the two and a half years during which the feasibility of electron-positron colliders was proved will be illustrated using archival and forgotten documents, in addition to transcripts from interviews with Carlo Bernardini, Peppino Di Giugno, Mario Fascetti, Francois Lacoste, and Jacques Ha\"issinski., Comment: 64 pages, 37 figures, in memory of Carlo Bernardini (1930-2018) and Bruno Touschek (1921-1978)
- Published
- 2018
33. PHOTON-2017 conference proceedings
- Author
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d'Enterria, David, de Roeck, Albert, Mangano, Michelangelo, Adam, Jaroslav, Alvioli, Massimiliano, Anson, Christopher D., Bakhshiansohi, Hamed, Baldenegro, Cristian, Bertone, Valerio, Brodsky, Stanley J., Bussey, Peter J., Chau, Chav Chhiv, Chou, Weiren, Chudasama, Ruchi, Cornet, Fernando, Dittmaier, Stefan, Dobrich, Babette, Dutta, Dipanwita, Ellis, John, Fichet, Sylvain, Frankfurt, Leonid, Garcia-Canal, Carlos, Godbole, Rohini M., Grau, Agnes, Guidal, Michel, Guo, Qianying, Guskov, Alexey, Guzey, Vadim, Harland-Lang, Lucian, Helenius, Ilkka, Hollar, Jonathan, Homma, Kensuke, Homola, Piotr, Huss, Alexander, Kaufmann, Tom, Khoze, Valery A., Klasen, Michael, Knapen, Simon, Kotko, Piotr, Krasnopevtsev, Dimitrii V., Krasny, Mieczyslaw W., Krupa, Beata, Kurihara, Yoshimasa, Lansberg, Jean-Philippe, Lin, Tongyan, Lou, Hou Keong, Lukina, Olga, Mantysaari, Heikki, Martins, Daniel, Masjuan, Pere, Massacrier, Laure, Mavromatos, Nick E., Melia, Tom, Mukherjee, Asmita, Novitzky, Norbert, Orava, Risto, Pagani, Davide, Pancheri, Giulia, Navarro, Albert Puig, Teles, Patricia Rebello, Ryskin, Mikhail G., Sanchez-Puertas, Pablo, Sasaki, Ken, Schwinn, Christian, Sciutto, Sergio J., Shen, Chengping, Strikman, Mark, Szymanowski, Lech, Tiberio, Alessio, Trzebinski, Maciej, Ueda, Tokahiro, Uematsu, Tsuneo, Vogelsang, Werner, Wagner, Jakub, Watanabe, Norihisa, Webb, Samuel, Wojton, Tomasz, You, Tevong, Zawiejski, Leszek, and Zhalov, Michael
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Nuclear Experiment ,Nuclear Theory - Abstract
This document collects the proceedings of the PHOTON 2017 conference ("International Conference on the Structure and the Interactions of the Photon", including the 22th "International Workshop on Photon-Photon Collisions", and the "International Workshop on High Energy Photon Colliders") held at CERN (Geneva) in May 2017. The latest experimental and theoretical developments on the topics of the PHOTON conference series are covered: (i) $\gamma\,\gamma$ processes in e$^+$e$^-$, proton-proton (pp) and nucleus-nucleus (AA) collisions at current and future colliders, (ii) $\gamma$-hadron interactions in e$^\pm$p, pp, and AA collisions, (iii) final-state photon production (including Standard Model studies and searches beyond it) in pp and AA collisions, and (iv) high-energy $\gamma$-ray astrophysics. These proceedings are dedicated to the memory of Maria Krawczyk., Comment: 296 pages. CERN-Proceedings-2018-001 (CERN, Geneva, 2018), to appear. arXiv admin note: substantial text overlap with arXiv:1804.05614, arXiv:1708.06683, arXiv:1709.09044, arXiv:1708.00912, arXiv:1708.07173, arXiv:1709.02985, arXiv:1709.00176, arXiv:1709.05167, arXiv:1708.05756, arXiv:1708.09759, arXiv:1708.07531, arXiv:1703.08450, arXiv:1711.02551, arXiv:1511.07794, arXiv:1712.10104, arXiv:1708.05776, arXiv:1712.10202, arXiv:1709.07110, arXiv:1702.08730, arXiv:1709.02648, arXiv:1411.6397
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- 2018
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34. Analysis and implications of precision near-forward TOTEM data
- Author
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Pancheri, Giulia, Pacetti, Simone, and Srivastava, Yogendra
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
Very precise data on elastic proton-proton scattering at $\sqrt{s}=7$, $8$ and $13$ TeV have been obtained by the TOTEM group at LHC in the near-forward region (momentum transfers down to $|t| = 6 \times 10^{-4}\ {\rm GeV}^2$ at $\sqrt{s}=8$ TeV and to $|t| = 8 \times 10^{-4}\ {\rm GeV}^2$ at $\sqrt{s}=13$ TeV). The Coulomb-nuclear interference has been measured with sufficient accuracy for TOTEM to establish the falloff of the $\rho$ parameter with increasing energy. The predictions from a previously studied model are shown to be in good agreement with the data and thus allow us to draw rather firm conclusions about the structure of the near-forward nuclear amplitude. We point out that due to a zero in the real part of the nuclear amplitude occurring at a very small momentum transfer--that can migrate into the Coulomb-nuclear interference (CNI) region at higher energies--much care is needed in extracting the numerical value of $\rho$ for such energies. Thus, the true value of $\rho$ would be higher than the TOTEM value for $\rho$ found under the hypothesis that the real part of the elastic nuclear amplitude is devoid of such a zero in the CNI region., Comment: 10 pages and 9 figures
- Published
- 2018
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35. Bruno Touschek and AdA: from Frascati to Orsay. In memory of Bruno Touschek, who passed away 40 years ago, on May 25th, 1978
- Author
-
Bonolis, Luisa and Pancheri, Giulia
- Subjects
Physics - History and Philosophy of Physics ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The first electron-positron collisions in a laboratory were observed in 1963-1964 at the Laboratoire de l'Acc\'el\'erateur Lin\'eaire d'Orsay, in France, with the storage ring AdA, which had been constructed in the Italian National Laboratories of Frascati in 1960, under the guidance of Bruno Touschek. The making of the collaboration between the two laboratories included visits between Orsay and Frascati, letters between Rome and Paris, and culminated with AdA leaving Frascati on July 4th, 1962 to cross the Alps on a truck, with the doughnut degassed to $10^{-9}$mmHg through pumps powered by sets of heavy batteries. This epoch-making trip and the exchanges which preceded it are described through unpublished documents and interviews with some of its protagonists, Carlo Bernardini, Francois Lacoste, Jacques Ha\"issinski, Maurice L\'evy., Comment: 31 pages, 14 figures, version with added text and a new figure
- Published
- 2018
36. Proprieties of FBK UFSDs after neutron and proton irradiation up to 6*10e15 neq/cm2
- Author
-
Mazza, S. M., Estrada, E., Galloway, Z., Gee, C., Goto, A., Luce, Z., McKinney-Martinez, F., Rodriguez, R., Sadrozinski, H. F. -W., Seiden, A., Smithers, B., Zhao, Y., Cindro, V., Kramberger, G., Mandić, I., Mikuž, M., Arcidiacono, M. Zavrtanik R., Cartiglia, N., Ferrero, M., Mandurrino, M., Sola, V., Staiano, A., Boscardin, M., Della Betta, G. F., Ficorella, F., Pancheri, L., and Paternoster, G.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The properties of 60-{\mu}m thick Ultra-Fast Silicon Detectors (UFSD) detectors manufactured by Fondazione Bruno Kessler (FBK), Trento (Italy) were tested before and after irradiation with minimum ionizing particles (MIPs) from a 90Sr \b{eta}-source . This FBK production, called UFSD2, has UFSDs with gain layer made of Boron, Boron low-diffusion, Gallium, Carbonated Boron and Carbonated. The irradiation with neutrons took place at the TRIGA reactor in Ljubljana, while the proton irradiation took place at CERN SPS. The sensors were exposed to a neutron fluence of 4*10e14, 8*1014, 1.5*10e15, 3*10e15, 6*10e15 neq/cm2 and to a proton fluence of 9.6*10e14 p/cm2, equivalent to a fluence of 6*10e14 neq/cm2. The internal gain and the timing resolution were measured as a function of bias voltage at -20C. The timing resolution was extracted from the time difference with a second calibrated UFSD in coincidence, using the constant fraction method for both., Comment: arXiv admin note: text overlap with arXiv:1803.02690
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- 2018
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37. A Democratic Resummation Procedure of Soft Gluon Emission for Hadronic Inelastic Cross-sections and Survival Probabilities
- Author
-
Pancheri, Giulia and Srivastava, Yogendra. N.
- Subjects
High Energy Physics - Phenomenology - Abstract
We discuss a model for soft gluon re-summation based on a statistical description of independent emissions during inelastic collisions. The model is applied to estimate Survival Probabilities at the LHC. A comparison with other models and experimental data is presented., Comment: 6 pages, 6 figures, to appear in the Proceedings of LFC17: Old and New Strong Interactions from LHC to Future Colliders, ECT*, Trento, 11-15 September 2017
- Published
- 2018
38. First FBK Production of 50$\mu$m Ultra-Fast Silicon Detectors
- Author
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Sola, V., Arcidiacono, R., Boscardin, M., Cartiglia, N., Betta, G. -F. Dalla, Ficorella, F., Ferrero, M., Mandurrino, M., Pancheri, L., Paternoster, G., and Staiano, A.
- Subjects
Physics - Instrumentation and Detectors - Abstract
Fondazione Bruno Kessler (FBK, Trento, Italy) has recently delivered its first 50 $\mu$m thick production of Ultra-Fast Silicon Detectors (UFSD), based on the Low-Gain Avalanche Diode design. These sensors use high resistivity Si-on-Si substrates, and have a variety of gain layer doping profiles and designs based on Boron, Gallium, Carbonated Boron and Carbonated Gallium to obtain a controlled multiplication mechanism. Such variety of gain layers will allow identifying the most radiation hard technology to be employed in the production of UFSD, to extend their radiation resistance beyond the current limit of $\phi \sim$ 10$^{15}$ n$_{eq}$/cm$^2$. In this paper, we present the characterisation, the timing performances, and the results on radiation damage tolerance of this new FBK production., Comment: 16 pages, 13 figures, 11th International "Hiroshima" Symposium on the Development and Application of Semiconductor Tracking Detectors (HSTD11) in conjunction with 2nd Workshop on SOI Pixel Detectors (SOIPIX2017) at OIST, Okinawa, Japan, Nuclear Instruments and Methods in Physics Research A (2018)
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- 2018
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39. Radiation resistant LGAD design
- Author
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Ferrero, M., Arcidiacono, R., Barozzi, M., Boscardin, M., Cartiglia, N., Betta, G. F. Dalla, Galloway, Z., Mandurrino, M., Mazza, S., Paternoster, G., Ficorella, F., Pancheri, L., Sadrozinski, H-F W., Sola, V., Staiano, A., Seiden, A., Siviero, F., Tornago, M., and Zhao, Y.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
In this paper, we report on the radiation resistance of 50-micron thick LGAD detectors manufactured at the Fondazione Bruno Kessler employing several different doping combinations of the gain layer. LGAD detectors with gain layer doping of Boron, Boron low-diffusion, Gallium, Carbonated Boron and Carbonated Gallium have been designed and successfully produced. These sensors have been exposed to neutron fluences up to $\phi_n \sim 3 \cdot 10^{16}\; n/cm^2$ and to proton fluences up to $\phi_p \sim 9\cdot10^{15}\; p/cm^2$ to test their radiation resistance. The experimental results show that Gallium-doped LGADs are more heavily affected by initial acceptor removal than Boron-doped LGAD, while the presence of Carbon reduces initial acceptor removal both for Gallium and Boron doping. Boron low-diffusion shows a higher radiation resistance than that of standard Boron implant, indicating a dependence of the initial acceptor removal mechanism upon the implant width. This study also demonstrates that proton irradiation is at least twice more effective in producing initial acceptor removal, making proton irradiation far more damaging than neutron irradiation., Comment: 22 pages, 17 figures
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- 2018
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40. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm
- Author
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Tremoulet, Adriana H, Jain, Sonia, Jone, Pei-Ni, Best, Brookie M, Duxbury, Elizabeth H, Franco, Alessandra, Printz, Beth, Dominguez, Samuel R, Heizer, Heather, Anderson, Marsha S, Glodé, Mary P, He, Feng, Padilla, Robert L, Shimizu, Chisato, Bainto, Emelia, Pancheri, Joan, Cohen, Harvey J, Whitin, John C, and Burns, Jane C
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Orphan Drug ,Clinical Trials and Supportive Activities ,Rare Diseases ,6.1 Pharmaceuticals ,Administration ,Oral ,Adolescent ,Atorvastatin ,Child ,Child ,Preschool ,Coronary Aneurysm ,Dose-Response Relationship ,Drug ,Drug Administration Schedule ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Male ,Mucocutaneous Lymph Node Syndrome ,Kawasaki disease ,atorvastatin ,coronary artery abnormalities ,statin ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics ,Paediatrics - Abstract
ObjectivesTo determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of a 6-week course of atorvastatin in patients with acute Kawasaki disease with coronary artery (CA) aneurysm (CAA).Study designThis was a Phase I/IIa 2-center dose-escalation study of atorvastatin (0.125-0.75 mg/kg/day) in 34 patients with Kawasaki disease (aged 2-17 years) with echocardiographic evidence of CAA. We measured levels of the brain metabolite 24(S)-hydroxycholesterol (24-OHC), serum lipids, acute-phase reactants, liver enzymes, and creatine phosphokinase; peripheral blood mononuclear cell populations; and CA internal diameter normalized for body surface area before atorvastatin treatment and at 2 and 6 weeks after initiation of atorvastatin treatment.ResultsA 6-week course of up to 0.75 mg/kg/day of atorvastatin was well tolerated by the 34 subjects (median age, 5.3 years; IQR, 2.6-6.4 years), with no serious adverse events attributable to the study drug. The areas under the curve for atorvastatin and its metabolite were larger in the study subjects compared with those reported in adults, suggesting a slower rate of metabolism in children. The 24-OHC levels were similar between the atorvastatin-treated subjects and matched controls.ConclusionsAtorvastatin was safe and well tolerated in our cohort of children with acute Kawasaki disease and CAA. A Phase III efficacy trial is warranted in this patient population, which may benefit from the known anti-inflammatory and immunomodulatory effects of this drug.
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- 2019
41. Selection of 8-channel silicon phototransistor arrays for space applications, based on wafer-level radiation and high-temperature storage tests
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Eshkevar Vakili, Aref, Bregoli, Matteo, Ceriani, Silvia, Bassetti, Daniel, Ficorella, Francesco, Pancheri, Lucio, and Bringer, Charlotte
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- 2022
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42. Beam test results of 25 and 35 μm thick FBK ultra-fast silicon detectors
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Carnesecchi, F., Strazzi, S., Alici, A., Arcidiacono, R., Borghi, G., Boscardin, M., Cartiglia, N., Centis Vignali, M., Cavazza, D., Dalla Betta, G. -F., Durando, S., Ferrero, M., Ficorella, F., Ali, O. Hammad, Mandurrino, M., Margotti, A., Menzio, L., Nania, R., Pancheri, L., Paternoster, G., Scioli, G., Siviero, F., Sola, V., Tornago, M., and Vignola, G.
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- 2023
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43. Regulators of collagen crosslinking in developing and adult tendons
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AJ Ellingson, NM Pancheri, and NR Schiele
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tendon ,development ,collagen ,crosslinking ,advanced glycation end products (ages) ,lysyl oxidase (lox) ,Diseases of the musculoskeletal system ,RC925-935 ,Orthopedic surgery ,RD701-811 - Abstract
Tendons are collagen-rich musculoskeletal tissues that possess the mechanical strength needed to transfer forces between muscles and bones. The mechanical development and function of tendons are impacted by collagen crosslinks. However, there is a limited understanding of how collagen crosslinking is regulated in tendon during development and aging. Therefore, the objective of the present review was to highlight potential regulators of enzymatic and non-enzymatic collagen crosslinking and how they impact tendon function. The main collagen crosslinking enzymes include lysyl oxidase (LOX) and the lysyl oxidase-like isoforms (LOXL), whereas non-enzymatic crosslinking is mainly mediated by the formation of advanced glycation end products (AGEs). Regulators of the LOX and LOXL enzymes may include mechanical stimuli, mechanotransducive cell signaling pathways, sex hormones, transforming growth factor (TGF)β family, hypoxia, and interactions with intracellular or extracellular proteins. AGE accumulation in tendon is due to diabetic conditions and aging, and can be mediated by diet and mechanical stimuli. The formation of these enzymatic and non-enzymatic collagen crosslinks plays a major role in tendon biomechanics and in the mechanisms of force transfer. A more complete understanding of how enzymatic and non-enzymatic collagen crosslinking is regulated in tendon will better inform tissue engineering and regenerative therapies aimed at restoring the mechanical function of damaged tendons.
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- 2022
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44. Maria Krawczyk: friend and physicist
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Godbole, Rohini M. and Pancheri, Giulia
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Physics - History and Philosophy of Physics - Abstract
With this note, we remember our friend Maria Krawczyk, who passed away this year, on May 24th. We briefly outline some of her physics interests and main accomplishments, and her great human and moral qualities., Comment: 3 pages, 1 figure, to be published in the Proceedings of PHOTON 2017: International Conference on the Structure and Interactions of the Photon, CERN 22-26 May, 2017
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- 2017
45. The non-diffractive pp cross-section and Survival Probabilities at LHC
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Pancheri, G., Grau, A., Srivastava, Y. N., Fagundes, D. A., and Shekhovtsova, O.
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High Energy Physics - Phenomenology - Abstract
We present an estimate of survival probability from an eikonal mini- jet model implemented with a proposal for soft gluon resummation to all orders. We compare it with experimental data for diffractive di-jet production from LHC experiments, CMS and ATLAS, both at LO and NLO order., Comment: 6 pages, 2 figures, Presented at EDS Blois 2017, Prague, Czech Republic, June 26-30, 2017
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- 2017
46. The path to high-energy electron-positron colliders: from Wideroe's betatron to Touschek's AdA and to LEP
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Pancheri, Giulia and Bonolis, Luisa
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Physics - History and Philosophy of Physics - Abstract
We describe the road which led to the construction and exploitation of electron positron colliders, hightlighting how the young physics student Bruno Touschek met the Norwegian engineer Rolf Wideroe in Germany, during WWII, and collaborated in building the 15 MeV betatron, a secret project directed by Wideroe and financed by the Ministry of Aviation of the Reich. This is how Bruno Touschek learnt the science of making particle accelerators and was ready, many years later, to propose and build AdA, the first electron positron collider, in Frascati, Italy, in 1960. We shall then see how AdA was brought from Frascati to Orsay, in France. Taking advantage of the Orsay Linear Accelerator as injector, the Franco-Italian team was able to prove that collisions had taken place, opening the way to the use of particle colliders as a mean to explore high energy physics., Comment: 14 pages, 2 figures, presented at Bristol Workshop on the History of Particle Colliders, to be published in the 2017 Newsletter of IOP History of Physics group
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- 2017
47. Photoproduction with a mini-jet model and Cosmic Ray showers
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Cornet, Fernando, Garcia-Canal, Carlos, Grau, Agnes, Pancheri, Giulia, and Sciutto, Sergio J.
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High Energy Physics - Phenomenology - Abstract
We present post-LHC updates of estimates of the total photo-production cross section in a mini-jet model with infrared soft gluon resummation, and apply the model to study Cosmic Ray shower development, comparing the results with those obtained from other existing models., Comment: 7 pages, 5 figures, presented at Photon 2017, 22-26 May 2017 CERN
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- 2017
48. Inelastic cross-section and Survival Probabilities at LHC in mini-jet models
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Fagundes, Daniel A., Grau, Agnes, Pancheri, Giulia, Shekhovtsova, Olga, and Srivastava, Yogendra N.
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High Energy Physics - Phenomenology - Abstract
Recent results for the total and inelastic hadronic cross-sections from LHC experiments are compared with predictions from a single channel PDF driven eikonal mini-jet model and from an empirical model. The role of soft gluon resummation in the infrared region in taming the rise of mini-jets and their contribution to the increase of the total cross-sections at high energies are discussed. Survival probabilities at LHC, whose theoretical estimates range from circa 10 percent to a few per mille, will be estimated in this model and compared with results from QCD inspired models and from multi channel eikonal models. We revisit a previous calculation and examine the origin of these discrepancies., Comment: 30 pages in single column, 6 figures
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- 2017
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49. Production of exotic composite quarks at the LHC
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Panella, O., Leonardi, R., Pancheri, G., Srivastava, Y. N., Narain, M., and Heintz, U.
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High Energy Physics - Phenomenology - Abstract
We consider the production at the LHC of exotic composite quarks of charge $Q=+(5/3) e$ and $Q=-(4/3) e$. Such states are predicted in composite models of higher isospin multiplets ($I_W=1$ or $I_W=3/2$). Given their exotic charges (such as $5/3$), their decays proceed through the electroweak interactions. We compute decay widths and rates for resonant production of the exotic quarks at the LHC. Partly motivated by the recent observation of an excess by the CMS collaboration in the $e\not p_T jj$ final state signature we focus on $ pp \to U^+ j \to W^+ + j\, j\, \to \ell^+\not p_T jj$ and then perform a fast simulation of the detector reconstruction based on DELPHES. We then scan the parameter space of the model ($m_*=\Lambda$) and study the statistical significance of the signal against the relevant standard model background ($Wjj$ followed by leptonic decay of the $W$ gauge boson) providing the luminosity curves as function of $m_*$ for discovery at 3- and 5-$\sigma$ level., Comment: 14 pages, 10 figures
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- 2017
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50. Kawasaki Disease Outcomes and Response to Therapy in a Multiethnic Community: A 10-Year Experience.
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Skochko, Shannon M, Jain, Sonia, Sun, Xiaoying, Sivilay, Nipha, Kanegaye, John T, Pancheri, Joan, Shimizu, Chisato, Sheets, Robert, Tremoulet, Adriana H, and Burns, Jane C
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Coronary Vessels ,Humans ,Coronary Aneurysm ,Mucocutaneous Lymph Node Syndrome ,Recurrence ,Inflammation ,Immunoglobulins ,Intravenous ,Treatment Outcome ,Incidence ,Prospective Studies ,Child ,Preschool ,Infant ,California ,Female ,Male ,Hispanic or Latino ,Asian ,Kawasaki disease ,coronary artery aneurysm ,epidemiology ,infliximab ,intravenous immunoglobulin ,Pediatric ,Clinical Research ,Asian Americans ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics - Abstract
ObjectivesTo describe the epidemiology, response to therapy, and outcomes of Kawasaki disease in a multiethnic community with a large Hispanic and Asian population.Study designWe analyzed prospectively collected data from 788 unselected patients with Kawasaki disease diagnosed and treated at a single medical center over a 10-year period.ResultsThe average incidence of Kawasaki disease in children
- Published
- 2018
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