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1. Challenges Regarding the Value of Routine Perioperative Transesophageal Echocardiography in Mitral Valve Surgery

Author

Iliuta, Luminita, primary, Rac-Albu, Madalina-Elena, additional, Panaitescu, Eugenia, additional, Andronesi, Andreea Gabriella, additional, Moldovan, Horatiu, additional, Furtunescu, Florentina Ligia, additional, Scafa-Udriște, Alexandru, additional, Dobra, Mihai Adrian, additional, Dinescu, Cristina Mirela, additional, Petrescu, Gheorghe Dodu, additional, and Rac-Albu, Marius, additional

Published
2024
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2. Non-invasive laboratory, imaging and elastography markers in predicting varices with high risk of bleeding in cirrhotic patients

Author

Petrisor Ana, Stanescu Ana Maria Alexandra, Papacocea Ioana Raluca, Panaitescu Eugenia, Peagu Razvan, Moldoveanu Alexandru Constantin, and Fierbinteanu-Braticevici Carmen

Subjects
liver cirrhosis, esophageal and gastric varices, gastrointestinal hemorrhage, elasticity imaging techniques, Internal medicine, RC31-1245
Abstract

Introduction. Upper digestive tract endoscopy remains the gold-standard for detecting esophageal or gastric varices and assessment of bleeding risk, but this method is invasive. The aim of the study was to identify non-invasive factors that could be incorporated into an algorithm for estimating the risk of variceal bleeding.

Published
2021
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5. Importance of Tissue Doppler Evaluation in Dilated Cardiomyopathy: The Value of Diastolic Filling Pattern as a Prognostic Predictor

Author

Iliuță, Luminita, primary, Andronesi, Andreea Gabriella, additional, Rac-Albu, Marius, additional, Rac-Albu, Mădălina-Elena, additional, Scafa-Udriște, Alexandru, additional, Moldovan, Horațiu, additional, Furtunescu, Florentina Ligia, additional, Rădulescu, Bogdan Constantin, additional, and Panaitescu, Eugenia, additional

Published
2023
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6. Systemic inflammation factors as survival prognosis markers in ovarian neoplasm and the relationship with cancer-associated inflammatory mediators—a review

Author

Dinca, Alexandra-Ligia, primary, Diaconu, Adriana, additional, Birla, Rodica Daniela, additional, Coculescu, Bogdan-Ioan, additional, Dinca, Valeriu-Gabi, additional, Manole, Gheorghe, additional, Marica, Cristian, additional, Tudorache, Ioan Sorin, additional, Panaitescu, Eugenia, additional, Constantinoiu, Silviu Marian, additional, and Coculescu, Elena Claudia, additional

Published
2023
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8. The Profile and All-Cause In-Hospital Mortality Dynamics of St-Segment Elevation Myocardial Infarction Patients during the Two Years of the COVID-19 Pandemic

Author

Popa-Fotea, Nicoleta-Monica, primary, Grigore, Iulia-Adelina, additional, Calmac, Lucian, additional, Mihai, Cosmin, additional, Bataila, Vlad, additional, Ploscaru, Vlad, additional, Dragoescu, Bogdan, additional, Moldovan, Horatiu, additional, Busnatu, Stefan-Sebastian, additional, Panaitescu, Eugenia, additional, Iliuță, Luminita, additional, and Scafa-Udriște, Alexandru, additional

Published
2023
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11. The Influence of the COVID-19 Pandemic on Mortality of Patients Hospitalized in Surgical Services in Romania: A Cross-Sectional Study of a National Survey

Author

Bîrlă, Rodica, primary, Panaitescu, Eugenia, additional, Ceban, Cornelia, additional, Radu, Andra-Victoria, additional, Hoară, Petre, additional, Constantin, Adrian, additional, Păduraru, Dan Nicolae, additional, Bordianu, Anca, additional, Cristian, Daniel Alin, additional, and Constantinoiu, Silviu, additional

Published
2022
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13. Mortality Risk Stratification in Emergency Surgery for Obstructive Colon Cancer—External Validation of International Scores, American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator (SRC), and the Dedicated Score of French Surgical Association (AFC/OCC Score)

Author

Mihailov, Raul, primary, Firescu, Dorel, additional, Constantin, Georgiana Bianca, additional, Mihailov, Oana Mariana, additional, Hoara, Petre, additional, Birla, Rodica, additional, Patrascu, Traian, additional, and Panaitescu, Eugenia, additional

Published
2022
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15. Challenges in Caring for People with Cardiovascular Disease through and beyond the COVID-19 Pandemic: The Advantages of Universal Access to Home Telemonitoring.

Author

Iliuță, Luminita, Andronesi, Andreea Gabriella, Rac-Albu, Marius, Furtunescu, Florentina Ligia, Rac-Albu, Mădălina-Elena, Scafa-Udriște, Alexandru, Moldovan, Horațiu, and Panaitescu, Eugenia

Subjects
LIFESTYLES, STATISTICS, HEALTH services accessibility, ANALYSIS of variance, HOME care services, MOBILE apps, CARDIOVASCULAR diseases, MANN Whitney U Test, REGRESSION analysis, TREATMENT effectiveness, PHYSICAL activity, T-test (Statistics), PEARSON correlation (Statistics), COMPARATIVE studies, DESCRIPTIVE statistics, CHI-squared test, PATIENT care, FRIEDMAN test (Statistics), DATA analysis, DATA analysis software, COVID-19 pandemic, TELEMEDICINE, LONGITUDINAL method
Abstract

(1) Background: Cardiovascular prevention was left in second place during the COVID-19 pandemic and the use of telemedicine turned out to be very useful. We aimed to evaluate the effectiveness of a telemedicine application for remote monitoring and treatment adjustments in terms of improving cardiovascular prevention. (2) Methods: A prospective study of 3439 patients evaluated between the 1st of March 2019 and the 1st of March 2022, in the pre-pandemic period by face-to-face visits and during the pandemic by teleconsultations or hybrid follow-up. We compared four periods: pre-pandemic—Pre-P (1 March 2019–1 March 2020), lockdown—Lock (1 March–1 September 2020), restrictive-pandemic—Restr-P (1 September 2020–1 March 2021), and relaxed–pandemic—Rel-P (1 March 2021–1 March 2022). (3) Results: The average values of total cholesterol (TC), LDL cholesterol, triglycerides, uric acid, and glucose had an increasing trend during Lock and Restr-P, and they decreased close to the baseline level during the Rel-P, with the exception of glucose which remained elevated in Rel-P. The number of patients with newly discovered DM increased significantly in the Rel-P, and 79.5% of them had mild/moderate forms of COVID-19. During Lock and Res-P, the percentage of obese, smoking, or hypertensive patients increased, but probably through the use of telemedicine, we managed to reduce it, although it remained slightly higher than the pre-pandemic level. Physical activity decreased in the first year of the pandemic, but in Rel-P people became more active than before the pandemic. (4) Conclusions: The use of telemedicine for cardiovascular prevention seems to yield favorable results, especially for secondary prevention in the very high-risk group and during the second year. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Telemedicine for Optimizing Secondary Prevention in Coronary Artery Bypass Grafting Patients during COVID-19 Pandemic.

Author

Iliuță, Luminița, Andronesi, Andreea Gabriella, Rac-Albu, Marius, Rac-Albu, Mădălina-Elena, Scafa-Udriște, Alexandru, Moldovan, Horațiu, Furtunescu, Florentina Ligia, Rădulescu, Bogdan Constantin, and Panaitescu, Eugenia

Subjects
CARDIOVASCULAR disease prevention, MEDICAL consultation, LIFESTYLES, CARDIOVASCULAR diseases risk factors, STATISTICS, CORONARY artery bypass, ANALYSIS of variance, QUANTITATIVE research, PATIENT monitoring, COMPARATIVE studies, PEARSON correlation (Statistics), DESCRIPTIVE statistics, CHI-squared test, DATA analysis software, DATA analysis, FRIEDMAN test (Statistics), COVID-19 pandemic, TELEMEDICINE, LONGITUDINAL method
Abstract

(1) Background: The COVID-19 pandemic has introduced a major disruption to the delivery of secondary prevention measures in patients with established atherosclerotic cardiovascular disease (CVD). It required a rapid and widespread adoption of new medical services, including the use of telemedicine. This study aimed to examine the impact of COVID-19 on secondary prevention in patients with coronary artery bypass grafting (CABG) and to evaluate the effectiveness of the telemedicine application for the implementation of lifestyle change measures, remote monitoring, and treatment regimen adjustment; (2) Methods: This prospective study on 194 CABG patients evaluated three consecutive years between 2019 and 2022 in the pre-pandemic period by face-to-face visits and during the pandemic by teleconsultations or hybrid follow-up. Variables of interest were compared between four periods: pre-pandemic—pre-P (1 March 2019–29 February 2020), lockdown—Lock (1 March–31 August 2020), restrictive-pandemic—Restr-P (1 September 2020–28 February 2021), and relaxed–pandemic—Rel-P (1 March 2021–1 March 2022). (3) Results: The average values of the lipidogram, blood sugar, and uric acid increased during Lock and Restr-P, but, through the use of teleprevention, they returned to the pre-pandemic level or even below this level. The exception was blood sugar, which remained high in Rel-P. The number of newly diagnosed patients with diabetes also increased, with most of them having moderate forms of COVID. During Lock and Res-P, the percentage of obese, smoking, or hypertensive patients increased, but, through the use of teleprevention, we managed to reduce it, although it remained slightly higher than the pre-pandemic level. Physical activity decreased in the first year of the pandemic, but, in Rel-P, CABG patients became more active than before the pandemic (4) Conclusions: The use of telemedicine for cardiovascular secondary prevention allowed us to not only continue seeing CABG patients but, also, to adjust their medication and to expand cardiovascular preventive counseling and testing with favorable results, especially during the second year of the pandemic. [ABSTRACT FROM AUTHOR]

Published
2023
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19. The serum level of the immunomodulatory peptide cathelicidin LL37 and T helper cell type 1 inflammatory response in viral hepatitis B, C, and D

Author

Iacob Simona Alexandra, Panaitescu Eugenia, Iacob Diana G., and Cojocaru Manole

Subjects
cathelicidine ll37, th1 response, viral hepatitis, cathelicidina ll37, răspuns thl, hepatite virale, Medicine
Abstract

Cathelicidina LL37 este un peptid antimicrobicin aparţinând imunităţii înnăscute, implicat în modularea IFN-y, citokina cheie a răspunsului T helper de tip 1. Rolul LL37 în răspunsul inflamator din cursul hepatitelor virale este necunoscut\ Am evaluat variaţiile serice ale LL37 şi răspunsul Thl în infecţiile cu virus hepatitic C (HCV), cu virus hepatitis B (HBV) şi cu virus hepatitic D (HDV). Nivelul LL37 (analizat prin test ELISA) şi răs- punsul Thl (definit prin nivelul IFN-y şi numărul de celule CD4+ şi CD8+) au fost analizate la 87 pacienţi (65 cu hepatită (34 HCV, 18 HBV, 13 HDV) şi 22 martori sănătoşi. Subiecţii, 33 bărbaţi/54 femei, între 20-64 ani, au fost selectaţi la Institutul Matei Balş, Bucureşti, România, în septembrie 2011 -martie 2012. Pacienţii cu he- patită au fost analizaţi în funcţie de etiologie şi de activitatea virală (activi vs inactivi). S-a folosit testul t student şi Mann Whitney. In grupul total de hepatite au fost detectate nivele ridicate de LL37 (138,09±88,45ng/ml, p=0,045) şi IFN-y (69,82pg/ml, p=0,005). în hepatita C activă nivelul de LL37 a fost semnificativ crescut (155,15±78,84ng/ml, p=0,014) şi răspunsul Thl a fost predominant în raport cu forma inactivă. Dimpotrivă, pa- cienţii cu hepatită B activă au prezentat LL37 scăzut (76,75ng/ml, p=0,009), fără răspuns Thl dominant compa- rativ cu forma inactivă. în hepatita D s-au întâlnit nivele de LL37 crescute până la 171,01 ±72,08ng/ml şi un răs- puns moderat Thl. Rezultatele indică un răspuns imun puternic şi concordant în hepatita C activă şi nivele cres- cute de LL37 în toate hepatitele virale.

Published
2013
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20. A Novel Clinical Nomogram for Predicting Overall Survival in Patients with Emergency Surgery for Colorectal Cancer.

Author

Constantin, Georgiana Bianca, Firescu, Dorel, Mihailov, Raul, Constantin, Iulian, Ștefanopol, Ioana Anca, Iordan, Daniel Andrei, Ștefănescu, Bogdan Ioan, Bîrlă, Rodica, and Panaitescu, Eugenia

Subjects
NOMOGRAPHY (Mathematics), SURGICAL emergencies, COLORECTAL cancer, OVERALL survival, PROCTOLOGY, ONCOLOGIC surgery
Abstract

Background: Long-term survival after emergency colorectal cancer surgery is low, and its estimation is most frequently neglected, with priority given to the immediate prognosis. This study aimed to propose an effective nomogram to predict overall survival in these patients. Materials and methods: We retrospectively studied 437 patients who underwent emergency surgery for colorectal cancer between 2008 and 2019, in whom we analyzed the clinical, paraclinical, and surgical parameters. Results: Only 30 patients (6.86%) survived until the end of the study. We identified the risk factors through the univariate Cox regression analysis and a multivariate Cox regression model. The model included the following eight independent prognostic factors: age > 63 years, Charlson score > 4, revised cardiac risk index (RCRI), LMR (lymphocytes/neutrophils ratio), tumor site, macroscopic tumoral invasion, surgery type, and lymph node dissection (p < 0.05 for all), with an AUC (area under the curve) of 0.831, with an ideal agreement between the predicted and observed probabilities. On this basis, we constructed a nomogram for prediction of overall survival. Conclusions: The nomogram created, on the basis of a multivariate logistic regression model, has a good individual prediction of overall survival for patients with emergency surgery for colon cancer and may support clinicians when informing patients about prognosis. [ABSTRACT FROM AUTHOR]

Published
2023
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25. The Influence of the COVID-19 Pandemic on Mortality of Patients Hospitalized in Surgical Services in Romania: A Cross-Sectional Study of a National Survey.

Author

Bîrlă, Rodica, Panaitescu, Eugenia, Ceban, Cornelia, Radu, Andra-Victoria, Hoară, Petre, Constantin, Adrian, Păduraru, Dan Nicolae, Bordianu, Anca, Cristian, Daniel Alin, and Constantinoiu, Silviu

Abstract

Surgical practice worldwide has changed rapidly in response to the coronavirus disease 2019 (COVID-19) pandemic. The study aimed to analyze the impact of the COVID-19 pandemic on mortality, in hospitalized patients, in Romanian surgical services. We have developed our research on a national survey of the consecutive records of hospitalizations, surgical interventions and deaths performed in Romania between March and August 2020. Results show that 47 surgical departments responded to the request. The admissions in the period March–August 2020 represented 52% of that from the similar period of 2019. In the studied period, the share of surgical interventions in patients admitted to non-COVID-19 centres was 98.7%, respectively 78.2% in COVID-19 support hospitals (p < 0.05), and emergency interventions of 43.4% in non-COVID-19 hospitals, respectively 84.8% in COVID-19 support hospitals (p < 0.05). Overall mortality in this period was 5.82%, compared to 3.28% in a similar period in 2019, (p < 0.05). Postoperative mortality in COVID-19-positive patients was 19%. In conclusion, in the hospitals in Romania included in the survey, the overall mortality in the studied period was higher than in a similar period in 2019. In patients with COVID-19 positive, the recorded postoperative mortality was higher than overall mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Predictors of spontaneous bacterial peritonitis in Romanian adults with liver cirrhosis: Focus on the neutrophil‑to‑lymphocyte ratio

Author

Popoiag, Roxana-Emanuela, primary, Suceveanu, Andra-Iulia, additional, Suceveanu, Adrian-Paul, additional, Micu, Sergiu, additional, Voinea, Felix, additional, Mazilu, Laura, additional, Petcu, Lucian, additional, Panaitescu, Eugenia, additional, Cozaru, Georgeta, additional, and Fierbințeanu‑Braticevici, Carmen, additional

Published
2021
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27. Spontaneous bacterial peritonitis mortality trends of cirrhotic patients in the last decade in Constanta County

Author

Popoiag, Roxana-Emanuela, primary, Panaitescu, Eugenia, additional, Suceveanu, Andra-Iulia, additional, Suceveanu, Adrian-Paul, additional, Micu, Sergiu, additional, Mazilu, Laura, additional, Parepa, Irinel, additional, Voinea, Felix, additional, Costea, Daniel, additional, Enache, Florin, additional, and Fierbințeanu-Braticevici, Carmen, additional

Published
2021
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38. Melanoma and immunotherapy bridge 2015

Author

Nanda, Vashisht G. Y., Peng, Weiyi, Hwu, Patrick, Davies, Michael A., Ciliberto, Gennaro, Fattore, Luigi, Malpicci, Debora, Aurisicchio, Luigi, Ascierto, Paolo Antonio, Croce, Carlo M., Mancini, Rita, Spranger, Stefani, Gajewski, Thomas F., Wang, Yangyang, Ferrone, Soldano, Vanpouille-Box, Claire, Wennerberg, Erik, Pilones, Karsten A., Formenti, Silvia C., Demaria, Sandra, Tang, Haidong, Wang, Yang, Fu, Yang-Xin, Dummer, Reinhard, Puzanov, Igor, Tarhini, Ahmad, Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sanders, Cindy, Kirkwood, John M., Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J., Zarour, Hassane M., Stroncek, David F., Huber, Veronica, Rivoltini, Licia, Thurin, Magdalena, Rau, Tilman, Lugli, Alessandro, Pagès, Franck, Camarero, Jorge, Sancho, Arantxa, Jommi, Claudio, de Coaña, Yago Pico, Wolodarski, Maria, Yoshimoto, Yuya, Gentilcore, Giusy, Poschke, Isabel, Masucci, Giuseppe V., Hansson, Johan, Kiessling, Rolf, Scognamiglio, Giosuè, Sabbatino, Francesco, Marino, Federica Zito, Anniciello, Anna Maria, Cantile, Monica, Cerrone, Margherita, Scala, Stefania, D’alterio, Crescenzo, Ianaro, Angela, Cirin, Giuseppe, Liguori, Giuseppina, Bott, Gerardo, Chapman, Paul B., Robert, Caroline, Larkin, James, Haanen, John B., Ribas, Antoni, Hogg, David, Hamid, Omid, Testori, Alessandro, Lorigan, Paul, Sosman, Jeffrey A., Flaherty, Keith T., Yue, Huibin, Coleman, Shelley, Caro, Ivor, Hauschild, Axel, McArthur, Grant A., Sznol, Mario, Callahan, Margaret K., Kluger, Harriet, Postow, Michael A., Gordan, RuthAnn, Segal, Neil H., Rizvi, Naiyer A., Lesokhin, Alexander, Atkins, Michael B., Burke, Matthew M., Ralabate, Amanda, Rivera, Angel, Kronenberg, Stephanie A., Agunwamba, Blessing, Ruisi, Mary, Horak, Christine, Jiang, Joel, Wolchok, Jedd, Ascierto, Paolo A., Liszkay, Gabriella, Maio, Michele, Mandalà, Mario, Demidov, Lev, Stoyakovskiy, Daniil, Thomas, Luc, de la Cruz-Merino, Luis, Atkinson, Victoria, Dutriaux, Caroline, Garbe, Claus, Wongchenko, Matthew, Chang, Ilsung, Koralek, Daniel O., Rooney, Isabelle, Yan, Yibing, Dréno, Brigitte, Sullivan, Ryan, Patel, Manish, Hodi, Stephen, Amaria, Rodabe, Boasberg, Peter, Wallin, Jeffrey, He, Xian, Cha, Edward, Richie, Nicole, Ballinger, Marcus, Smith, David C., Bauer, Todd M., Wasser, Jeffrey S., Luke, Jason J., Balmanoukian, Ani S., Kaufman, David R., Zhao, Yufan, Maleski, Janet, Leopold, Lance, Gangadhar, Tara C., Long, Georgina V., Michielin, Olivier, VanderWalde, Ari, Andtbacka, Robert H. I., Cebon, Jonathan, Fernandez, Eugenio, Malvehy, Josep, Olszanski, Anthony J., Gause, Christine, Chen, Lisa, Chou, Jeffrey, Stephen Hodi, F., Brady, Benjamin, Mortier, Laurent, Hassel, Jessica C., Rutkowski, Piotr, McNeil, Catriona, Kalinka-Warzocha, Ewa, Lebbé, Celeste, Ny, Lars, Chacon, Matias, Queirolo, Paola, Loquai, Carmen, Cheema, Parneet, Berrocal, Alfonso, Eizmendi, Karmele Mujika, Bar-Sela, Gil, Hardy, Helene, Weber, Jeffrey S., Grob, Jean-Jacques, Marquez-Rodas, Ivan, Schmidt, Henrik, Briscoe, Karen, Baurain, Jean-François, Wolchok, Jedd D., Pinto, Rosamaria, De Summa, Simona, Garrisi, Vito Michele, Strippoli, Sabino, Azzariti, Amalia, Guida, Gabriella, Guida, Michele, Tommasi, Stefania, Jacquelot, Nicolas, Enot, David, Flament, Caroline, Pitt, Jonathan M., Vimond, Nadège, Blattner, Carolin, Yamazaki, Takahiro, Roberti, Maria-Paula, Vetizou, Marie, Daillere, Romain, Poirier-Colame, Vichnou, la Semeraro, Michaë, Caignard, Anne, Slingluff, Craig L, Sallusto, Federica, Rusakiewicz, Sylvie, Weide, Benjamin, Marabelle, Aurélien, Kohrt, Holbrook, Dalle, Stéphane, Cavalcanti, Andréa, Kroemer, Guido, Di Giacomo, Anna Maria, Maio, Michaele, Wong, Phillip, Yuan, Jianda, Umansky, Viktor, Eggermont, Alexander, Zitvogel, Laurence, Anna, Passarelli, Marco, Tucci, Stefania, Stucci, Francesco, Mannavola, Mariaelena, Capone, Gabriele, Madonna, Antonio, Ascierto Paolo, Franco, Silvestris, Roberti, María Paula, Enot, David P., Semeraro, Michaela, Jégou, Sarah, Flores, Camila, Kwon, Byoung S., Anderson, Ana Carrizossa, Borg, Christophe, Aubin, François, Ayyoub, Maha, De Presbiteris, Anna Lisa, Cordaro, Fabiola Gilda, Camerlingo, Rosa, Fratangelo, Federica, Mozzillo, Nicola, Pirozzi, Giuseppe, Patriarca, Eduardo J., Caputo, Emilia, Motti, Maria Letizia, Falcon, Rosaria, Miceli, Roberta, Capone, Mariaelena, Madonna, Gabriele, Mallardo, Domenico, Carrier, Maria Vincenza, Panza, Elisabetta, De Cicco, Paola, Armogida, Chiara, Ercolano, Giuseppe, Botti, Gerardo, Cirino, Giuseppe, Sandru, Angela, Blank, Miri, Balatoni, Timea, Olasz, Judit, Farkas, Emil, Szollar, Andras, Savolt, Akos, Godeny, Maria, Csuka, Orsolya, Horvath, Szabolcs, Eles, Klara, Shoenfeld, Yehuda, Kasler, Miklos, Costantini, Susan, Capone, Francesca, Moradi, Farnaz, Berglund, Pontus, Leandersson, Karin, Linnskog, Rickard, Andersson, Tommy, Prasad, Chandra Prakash, Nigro, Cristiana Lo, Lattanzio, Laura, Wang, Hexiao, Proby, Charlotte, Syed, Nelofer, Occelli, Marcella, Cauchi, Carolina, Merlano, Marco, Harwood, Catherine, Thompson, Alastair, Crook, Tim, Bifulco, Katia, Ingangi, Vincenzo, Minopoli, Michele, Ragone, Concetta, Pessi, Antonello, Mannavola, Francesco, D’Oronzo, Stella, Felici, Claudia, Tucci, Marco, Doronzo, Antonio, Silvestris, Franco, Ferretta, Anna, Guida, Stefania, Maida, Imma, Cocco, Tiziana, Passarelli, Anna, Quaresmini, Davide, Franzese, Ornella, Palermo, Belinda, Di Donna, Cosmo, Sperduti, Isabella, Foddai, MariaLaura, Stabile, Helena, Gismondi, Angela, Santoni, Angela, Nisticò, Paola, Sponghini, Andrea P., Platini, Francesca, Marra, Elena, Rondonotti, David, Alabiso, Oscar, Fierro, Maria T., Savoia, Paola, Stratica, Florian, Quaglino, Pietro, Di Monta, Gianluca, Corrado, Caracò, Di Marzo, Massimiliano, Ugo, Marone, Di Cecilia, Maria Luisa, Nicola, Mozzillo, Fusciello, Celeste, Marra, Antonio, Guarrasi, Rosario, Baldi, Carlo, Russo, Rosa, Di Giulio, Giovanni, Faiola, Vincenzo, Zeppa, Pio, Pepe, Stefano, Gambale, Elisabetta, Carella, Consiglia, Di Paolo, Alessandra, De Tursi, Michele, Marra, Laura, De Murtas, Fara, Sorrentino, Valeria, Voinea, Silviu, Panaitescu, Eugenia, Bolovan, Madalina, Stanciu, Adina, Cinca, Sabin, Botti, Chiara, Aquino, Gabriella, Anniciello, Annamaria, Fortes, Cristina, Mastroeni, Simona, Caggiati, Alessio, Passarelli, Francesca, Zappalà, Alba, Capuano, Maria, Bono, Riccardo, Nudo, Maurizio, Marino, Claudia, Michelozzi, Paola, De Biasio, Valeria, Battarra, Vincenzo C., Formenti, Silvia, Ascierto, Maria Libera, McMiller, Tracee L., Berger, Alan E., Danilova, Ludmila, Anders, Robert A., Netto, George J., Xu, Haiying, Pritchard, Theresa S., Fan, Jinshui, Cheadle, Chris, Cope, Leslie, Drake, Charles G., Pardoll, Drew M., Taube, Janis M., Topalian, Suzanne L., Gnjatic, Sacha, Nataraj, Sarah, Imai, Naoko, Rahman, Adeeb, Jungbluth, Achim A., Pan, Linda, Venhaus, Ralph, Park, Andrew, Lehmann, Frédéric F., Lendvai, Nikoletta, Cohen, Adam D., Cho, Hearn J., Daniel, Speiser, and Hirsh, Vera

Subjects
Medicine(all), Biochemistry, Genetics and Molecular Biology(all), Meeting Abstracts
Abstract

Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunoscore task force: an update K15 The immunoscore in colorectal cancer highlights the importance of digital scoring systems in surgical pathology Tilman Rau, Alessandro Lugli K16 The immunoscore: toward an integrated immunomonitoring from the diagnosis to the follow up of cancer’s patients Franck Pagès Economic sustainability of melanoma treatments: regulatory, health technology assessment and market access issues K17 Nivolumab, the regulatory experience in immunotherapy Jorge Camarero, Arantxa Sancho K18 Evidence to optimize access for immunotherapies Claudio Jommi ORAL PRESENTATIONS Molecular and immuno-advances O1 Ipilimumab treatment results in CD4 T cell activation that is concomitant with a reduction in Tregs and MDSCs Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, Giuseppe V. Masucci, Johan Hansson, Rolf Kiessling O2 Evaluation of prognostic and therapeutic potential of COX-2 and PD-L1 in primary and metastatic melanoma Giosuè Scognamiglio, Francesco Sabbatino, Federica Zito Marino, Anna Maria Anniciello, Monica Cantile, Margherita Cerrone, Stefania Scala, Crescenzo D’alterio, Angela Ianaro, Giuseppe Cirino, Paolo Antonio Ascierto, Giuseppina Liguori, Gerardo Botti O3 Vemurafenib in patients with BRAFV600 mutation–positive metastatic melanoma: final overall survival results of the BRIM-3 study Paul B. Chapman, Caroline Robert, James Larkin, John B. Haanen, Antoni Ribas, David Hogg, Omid Hamid, Paolo Antonio Ascierto, Alessandro Testori, Paul Lorigan, Reinhard Dummer, Jeffrey A. Sosman, Keith T. Flaherty, Huibin Yue, Shelley Coleman, Ivor Caro, Axel Hauschild, Grant A. McArthur O4 Updated survival, response and safety data in a phase 1 dose-finding study (CA209-004) of concurrent nivolumab (NIVO) and ipilimumab (IPI) in advanced melanoma Mario Sznol, Margaret K. Callahan, Harriet Kluger, Michael A. Postow, RuthAnn Gordan, Neil H. Segal, Naiyer A. Rizvi, Alexander Lesokhin, Michael B. Atkins, John M. Kirkwood, Matthew M. Burke, Amanda Ralabate, Angel Rivera, Stephanie A. Kronenberg, Blessing Agunwamba, Mary Ruisi, Christine Horak, Joel Jiang, Jedd Wolchok Combination therapies O5 Efficacy and correlative biomarker analysis of the coBRIM study comparing cobimetinib (COBI) + vemurafenib (VEM) vs placebo (PBO) + VEM in advanced BRAF-mutated melanoma patients (pts) Paolo A. Ascierto, Grant A. McArthur, James Larkin, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stoyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Matthew Wongchenko, Ilsung Chang, Daniel O. Koralek, Isabelle Rooney, Yibing Yan, Antoni Ribas, Brigitte Dréno O6 Preliminary clinical safety, tolerability and activity results from a Phase Ib study of atezolizumab (anti-PDL1) combined with vemurafenib in BRAFV600-mutant metastatic melanoma Ryan Sullivan, Omid Hamid, Manish Patel, Stephen Hodi, Rodabe Amaria, Peter Boasberg, Jeffrey Wallin, Xian He, Edward Cha, Nicole Richie, Marcus Ballinger, Patrick Hwu O7 Preliminary safety and efficacy data from a phase 1/2 study of epacadostat (INCB024360) in combination with pembrolizumab in patients with advanced/metastatic melanoma Thomas F. Gajewski, Omid Hamid, David C. Smith, Todd M. Bauer, Jeffrey S. Wasser, Jason J. Luke, Ani S. Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar O8 Primary analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma Reinhard Dummer, Georgina V. Long, Antoni Ribas, Igor Puzanov, Olivier Michielin, Ari VanderWalde, Robert H.I. Andtbacka, Jonathan Cebon, Eugenio Fernandez, Josep Malvehy, Anthony J. Olszanski, Thomas F. Gajewski, John M. Kirkwood, Christine Gause, Lisa Chen, David R. Kaufman, Jeffrey Chou, F. Stephen Hodi News in immunotherapy O9 Two-year survival and safety update in patients (pts) with treatment-naïve advanced melanoma (MEL) receiving nivolumab (NIVO) or dacarbazine (DTIC) in CheckMate 066 Victoria Atkinson, Paolo A. Ascierto, Georgina V. Long, Benjamin Brady, Caroline Dutriaux, Michele Maio, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona McNeil, Ewa Kalinka-Warzocha, Celeste Lebbé, Lars Ny, Matias Chacon, Paola Queirolo, Carmen Loquai, Parneet Cheema, Alfonso Berrocal, Karmele Mujika Eizmendi, Luis De La Cruz-Merino, Gil Bar-Sela, Christine Horak, Joel Jiang, Helene Hardy, Caroline Robert O10 Efficacy and safety of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL) who were treated beyond progression in CheckMate 066/067 Georgina V. Long, Jeffrey S. Weber, James Larkin, Victoria Atkinson, Jean-Jacques Grob, Reinhard Dummer, Caroline Robert, Ivan Marquez-Rodas, Catriona McNeil, Henrik Schmidt, Karen Briscoe, Jean-François Baurain, F. Stephen Hodi, Jedd D. Wolchok Tumor microenvironment and biomarkers O11 New biomarkers for response/resistance to BRAF inhibitor therapy in metastatic melanoma Rosamaria Pinto, Simona De Summa, Vito Michele Garrisi, Sabino Strippoli, Amalia Azzariti, Gabriella Guida, Michele Guida, Stefania Tommasi O12 Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma and response to ipilimumab Nicolas Jacquelot, David Enot, Caroline Flament, Jonathan M. Pitt, Nadège Vimond, Carolin Blattner, Takahiro Yamazaki, Maria-Paula Roberti, Marie Vetizou, Romain Daillere, Vichnou Poirier-Colame, Michaëla Semeraro, Anne Caignard, Craig L Slingluff Jr, Federica Sallusto, Sylvie Rusakiewicz, Benjamin Weide, Aurélien Marabelle, Holbrook Kohrt, Stéphane Dalle, Andréa Cavalcanti, Guido Kroemer, Anna Maria Di Giacomo, Michaele Maio, Phillip Wong, Jianda Yuan, Jedd Wolchok, Viktor Umansky, Alexander Eggermont, Laurence Zitvogel O13 Serum levels of PD1- and CD28-positive exosomes before Ipilimumab correlate with therapeutic response in metastatic melanoma patients Passarelli Anna, Tucci Marco, Stucci Stefania, Mannavola Francesco, Capone Mariaelena, Madonna Gabriele, Ascierto Paolo Antonio, Silvestris Franco O14 Immunological prognostic factors in stage III melanomas María Paula Roberti, Nicolas Jacquelot, David P Enot, Sylvie Rusakiewicz, Michaela Semeraro, Sarah Jégou, Camila Flores, Lieping Chen, Byoung S. Kwon, Ana Carrizossa Anderson, Caroline Robert, Christophe Borg, Benjamin Weide, François Aubin, Stéphane Dalle, Michele Maio, Jedd D. Wolchok, Holbrook Kohrt, Maha Ayyoub, Guido Kroemer, Aurélien Marabelle, Andréa Cavalcanti, Alexander Eggermont, Laurence Zitvogel POSTER PRESENTATIONS Molecular and immuno-advances P1 Human melanoma cells resistant to B-RAF and MEK inhibition exhibit mesenchymal-like features Anna Lisa De Presbiteris, Fabiola Gilda Cordaro, Rosa Camerlingo, Federica Fratangelo, Nicola Mozzillo, Giuseppe Pirozzi, Eduardo J. Patriarca, Paolo A. Ascierto, Emilia Caputo P2 Anti-proliferative and pro-apoptotic effect of ABT888 on melanoma cell lines and its potential role in the treatment of melanoma resistant to B-RAF inhibitors Federica Fratangelo, Rosa Camerlingo, Emilia Caputo, Maria Letizia Motti, Rosaria Falcone, Roberta Miceli, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Maria Vincenza Carriero, Giuseppe Pirozzi and Paolo Antonio Ascierto P3 Involvement of the L-cysteine/CSE/H2S pathway in human melanoma progression Elisabetta Panza, Paola De Cicco, Chiara Armogida, Giuseppe Ercolano, Rosa Camerlingo, Giuseppe Pirozzi, Giosuè Scognamiglio, Gerardo Botti, Giuseppe Cirino, Angela Ianaro P4 Cancer stem cell antigen revealing pattern of antibody variable region genes were defined by immunoglobulin repertoire analysis in patients with malignant melanoma Beatrix Kotlan, Gabriella Liszkay, Miri Blank, Timea Balatoni, Judit Olasz, Emil Farkas, Andras Szollar, Akos Savolt, Maria Godeny, Orsolya Csuka, Szabolcs Horvath, Klara Eles, Yehuda Shoenfeld and Miklos Kasler P5 Upregulation of Neuregulin-1 expression is a hallmark of adaptive response to BRAF/MEK inhibitors in melanoma Debora Malpicci, Luigi Fattore, Susan Costantini, Francesca Capone, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto P6 HuR positively regulates migration of HTB63 melanoma cells Farnaz Moradi, Pontus Berglund, Karin Leandersson, Rickard Linnskog, Tommy Andersson, Chandra Prakash Prasad P7 Prolyl 4- (C-P4H) hydroxylases have opposing effects in malignant melanoma: implication in prognosis and therapy Cristiana Lo Nigro, Laura Lattanzio, Hexiao Wang, Charlotte Proby, Nelofer Syed, Marcella Occelli, Carolina Cauchi, Marco Merlano, Catherine Harwood, Alastair Thompson, Tim Crook P8 Urokinase receptor antagonists: novel agents for the treatment of melanoma Maria Letizia Motti, Katia Bifulco, Vincenzo Ingangi, Michele Minopoli, Concetta Ragone, Federica Fratangelo, Antonello Pessi, Gennaro Ciliberto, Paolo Antonio Ascierto, Maria Vincenza Carriero P9 Exosomes released by melanoma cell lines enhance chemotaxis of primary tumor cells Francesco Mannavola, Stella D’Oronzo, Claudia Felici, Marco Tucci, Antonio Doronzo, Franco Silvestris P10 New insights in mitochondrial metabolic reprogramming in melanoma Anna Ferretta, Gabriella Guida, Stefania Guida, Imma Maida, Tiziana Cocco, Sabino Strippoli, Stefania Tommasi, Amalia Azzariti, Michele Guida P11 Lenalidomide restrains the proliferation in melanoma cells through a negative regulation of their cell cycle Stella D’Oronzo, Anna Passarelli, Claudia Felici, Marco Tucci, Davide Quaresmini, Franco Silvestris Combination therapies P12 Chemoimmunotherapy elicits polyfunctional anti-tumor CD8 + T cells depending on the activation of an AKT pathway sustained by ICOS Ornella Franzese, Belinda Palermo, Cosmo Di Donna, Isabella Sperduti, MariaLaura Foddai, Helena Stabile, Angela Gismondi, Angela Santoni, Paola Nisticò P13 Favourable toxicity profile of combined BRAF and MEK inhibitors in metastatic melanoma patients Andrea P. Sponghini, Francesca Platini, Elena Marra, David Rondonotti, Oscar Alabiso, Maria T. Fierro, Paola Savoia, Florian Stratica, Pietro Quaglino P14 Electrothermal bipolar vessel sealing system dissection reduces seroma output or time to drain removal following axillary and ilio-inguinal node dissection in melanoma patients: a pilot study Di Monta Gianluca, Caracò Corrado, Di Marzo Massimiliano, Marone Ugo, Di Cecilia Maria Luisa, Mozzillo Nicola News in immunotherapy P15 Clinical and immunological response to ipilimumab in a metastatic melanoma patient with HIV infection Francesco Sabbatino, Celeste Fusciello1, Antonio Marra, Rosario Guarrasi, Carlo Baldi, Rosa Russo, Di Giulio Giovanni, Vincenzo Faiola, Pio Zeppa, Stefano Pepe P16 Immunotherapy and hypophysitis: a case report Elisabetta Gambale, Consiglia Carella, Alessandra Di Paolo, Michele De Tursi Tumor microenvironment and biomarkers P17 New immuno- histochemical markers for the differential diagnosis of atypical melanocytic lesions with uncertain malignant potential Laura Marra, Giosuè Scognamiglio, Monica Cantile, Margherita Cerrone, Fara De Murtas, Valeria Sorrentino, Anna Maria Anniciello, Gerardo Botti P18 Utility of simultaneous measurement of three serum tumor markers in melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P19 The significance of various cut-off levels of melanoma inhibitory activity in evaluation of cutaneous melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P20 The long noncoding RNA HOTAIR is associated to metastatic progression of melanoma and it can be identified in the blood of patients with advanced disease Chiara Botti, Giosuè Scognamiglio, Laura Marra, Gabriella Aquino, Rosaria Falcone, Annamaria Anniciello, Paolo Antonio Ascierto, Gerardo Botti, Monica Cantile Other P21 The effect of Sentinel Lymph Node Biopsy in melanoma mortality: timing of dissection Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi P22 Epidemiological survey on related psychopathology in melanoma Valeria De Biasio, Vincenzo C. Battarra IMMUNOTHERAPY BRIDGE KEYNOTE SPEAKER PRESENTATIONS Immunotherapy beyond melanoma K19 Predictor of response to radiation and immunotherapy Silvia Formenti K20 Response and resistance to PD-1 pathway blockade: clues from the tumor microenvironment Maria Libera Ascierto, Tracee L. McMiller, Alan E. Berger, Ludmila Danilova, Robert A. Anders, George J. Netto, Haiying Xu, Theresa S. Pritchard, Jinshui Fan, Chris Cheadle, Leslie Cope, Charles G. Drake, Drew M. Pardoll, Janis M. Taube and Suzanne L. Topalian K21 Combination immunotherapy with autologous stem cell transplantation, protein immunization, and PBMC reinfusion in myeloma patients Sacha Gnjatic, Sarah Nataraj, Naoko Imai, Adeeb Rahman, Achim A. Jungbluth, Linda Pan, Ralph Venhaus, Andrew Park, Frédéric F. Lehmann, Nikoletta Lendvai, Adam D. Cohen, and Hearn J. Cho K22 Anti-cancer immunity despite T cell “exhaustion” Speiser Daniel Immunotherapy in oncology (I-O): data from clinical trial K23 The Checkpoint Inhibitors for the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) Vera Hirsh

Published
2016

40. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

Author

Niculae, Cristian-Mihail, primary, Manea, Eliza, additional, Jipa, Raluca, additional, Merisor, Simona, additional, Moroti, Ruxandra, additional, Benea, Serban, additional, Hristea, Adriana, additional, Neguț, Alina Cristina, additional, Săndulescu, Oana, additional, Streinu-Cercel, Anca, additional, Mărculescu, Dana, additional, Andrei, Magdalena Lorena, additional, Ilie, Veronica, additional, Popa, Marcela, additional, Bleotu, Coralia, additional, Chifiriuc, Carmen, additional, Popa, Mircea Ioan, additional, Streinu-Cercel, Adrian, additional, Orfanu, Alina, additional, Popescu, Cristina, additional, Leuștean, Anca, additional, Catană, Remulus, additional, Negru, Anca, additional, Badea, Alexandra, additional, Orfanu, Radu, additional, Tilișcan, Cătălin, additional, Aramă, Victoria, additional, Aramă, Ştefan Sorin, additional, Vișan, Constanța-Angelica, additional, Drăgănescu, Anca-Cristina, additional, Bilașco, Anuța, additional, Kouris, Camelia, additional, Merișescu, Mădălina, additional, Vasile, Magdalena, additional, Slavu, Diana-Maria, additional, Vintilă, Sabina, additional, Osman, Endis, additional, Oprea, Alina, additional, Sandu, Sabina, additional, Luminos, Monica, additional, Leuştean, Anca, additional, Popescu, Gabriel Adrian, additional, Stanculete, Ramona Georgiana, additional, Enoiu, Ana Vaduva, additional, Marinescu, Adelina Raluca, additional, Lazureanu, Voichita, additional, Marinescu, Adelina-Raluca, additional, Crișan, Alexandru, additional, Lăzureanu, Voichița, additional, Musta, Virgil, additional, Nicolescu, Narcisa, additional, Laza, Ruxandra, additional, Negru, Anca-Ruxandra, additional, Munteanu, Daniela-Ioana, additional, Mihăilescu, Raluca, additional, Dorobăț, Olga, additional, Rafila, Alexandru, additional, Căpraru, Emilia, additional, Niculescu, Marius, additional, Marinescu, Rodica, additional, Lupescu, Olivera, additional, Predescu, Vlad, additional, Tălăpan, Daniela, additional, Popescu, Ramona Ștefania, additional, Bradu, Luminița, additional, Florea, Dragoș, additional, Leca, Daniela Anicuta, additional, Bunea, Elena, additional, Teodor, Andra, additional, Miftode, Egidia, additional, Jugulete, Gheorghiță, additional, Dobrotă, Anamaria, additional, Ilie, Adina, additional, Preoțescu, Liliana Lucia, additional, Irimescu, Nicoleta, additional, Panait, Irina, additional, Niculae, Cristian, additional, Gavriliu, Liana Cătălina, additional, Benea, Otilia Elisabeta, additional, Benea, Șerban, additional, Popoiu, Mona, additional, Dragonu, Livia, additional, Cupşa, Augustin, additional, Diaconescu, Iulian, additional, Niculescu, Irina, additional, Giubelan, Lucian, additional, Dumitrescu, Florentina, additional, Stoian, Andreea Cristina, additional, Guţă, Camelia, additional, Puiu, Simona, additional, Irina, Bunescu, additional, Vallée, Marilyse, additional, Huletsky, Ann, additional, Boudreau, Dominique K., additional, Bérubé, Ève, additional, Giroux, Richard, additional, Longtin, Jean, additional, Longtin, Yves, additional, Bergeron, Michel G., additional, Roșculeț, Cleo Nicoleta, additional, Toma, Dalila-Ana, additional, Ciuca, Catrinel, additional, Apostolescu, Cătălin, additional, Rogoz, Andrei, additional, Stangaciu, Andrei, additional, Mitescu, Viorica, additional, Vladoiu, Tudor, additional, Iovănescu, Doina, additional, Oana, Michaela, additional, Costin, Simona, additional, Moțoi, Maria Magdalena, additional, Dorobăț, Olga Mihaela, additional, Mihai, Alexandru, additional, Roşculeț, Cleo, additional, Popescu, Gabriel-Adrian, additional, Abagiu, Adrian, additional, Moroti-Constantinescu, Ruxandra, additional, Benea, Otilia, additional, Simoiu, Mădălina, additional, Bacruban, Rodica, additional, Bădicuț, Ioana, additional, Borcan, Alina, additional, Hurmuzache, Mihnea, additional, Enache, Georgiana, additional, Ciocan, Alexandra, additional, Bararu, Mircea, additional, Popazu, Madalina, additional, Iovănescu, Doina Viorica, additional, Apostolescu, Cătălin Gabriel, additional, Toma, Dalila, additional, Iliescu, Laura, additional, Minzala, Georgiana, additional, Toma, Letitia, additional, Baciu, Mihaela, additional, Tanase, Alina, additional, Orban, Carmen, additional, Pantea, Victor, additional, Placinta, Gheorghe, additional, Cebotarescu, Valentin, additional, Cojuhari, Lilia, additional, Jimbei, Paulina, additional, Dragomirescu, Cristina, additional, Murariu, Cristina, additional, Stratan, Laurențiu, additional, Munteanu, Daniela, additional, Năstase, Raluca, additional, Molagic, Violeta, additional, Rădulescu, Mihaela, additional, Diaconu, Ioan, additional, Bodosca, Iulia, additional, Niță, Violeta, additional, Năstase, Raluca Mihaela, additional, Bodoșca, Iulia, additional, Diaconu, Ioan Alexandru, additional, Erturk, Yagmur, additional, Șchiopu, Claudiu Mihai, additional, Tenita, Angelica, additional, Aramă, Ștefan Sorin, additional, Iacob, Simona Alexandra, additional, Iacob, Diana Gabriela, additional, Predescu, Mioara, additional, Mărdărescu, Alexandra, additional, Săndulescu, Mihai, additional, Ciuca, Catrinel Olimpia, additional, Toma, Dalila Ana, additional, Mitu, Cristina Elena, additional, Mitescu, Viorica Daniela, additional, Vladoiu, Tudor Gheorghe, additional, Stoica, Monica Andreea, additional, Manolache, Daniela, additional, Ceapraga, Gabriela Jana, additional, Mircea, Gabriela, additional, Durbală, Ionel, additional, Russu, Irina, additional, Holban, Tiberiu, additional, Pantilimonov, Tatiana, additional, Chiriacov, Galina, additional, Macvovei, Arcadie, additional, Scorohodico, Elena, additional, Dmitriev, Oleg, additional, Costache, Diana Alexandra, additional, Benea, Anca, additional, Benea, Elisabeta, additional, Mitran, Mihai, additional, Georgescu, Carmen, additional, Mitran, Loredana, additional, Vladareanu, Simona, additional, Magirescu, Andreea Ioana, additional, Andreev, Viorica, additional, Nicolau, Cristina, additional, Largu, Alexandra, additional, Dorobat, Carmen, additional, Manciuc, Carmen, additional, Isac, Ina, additional, Șerban, Iulia Gabriela, additional, Resul, Ghiulendan, additional, Marcaș, Consuela, additional, Marincu, Iosif, additional, Poptelecan, Patricia, additional, Trincă, Bogdan, additional, Mitrescu, Sorina, additional, Tudor, Anca, additional, Vlad, Daliborca, additional, Tirnea, Livius, additional, Baydaroglu, Nurcan, additional, Ceapraga, Gabriela, additional, Pagute, Mariana, additional, Dorobăț, Carmen, additional, Diaconu, Ioan-Alexandru, additional, Ion, Daniela, additional, Nichita, Luciana, additional, Diaconu, Alexandra, additional, Duport-Dodot, Irina, additional, Mărdărescu, Mariana, additional, Petre, Cristina, additional, Iancu, Marieta, additional, Ungurianu, Rodica, additional, Cibea, Alina, additional, Drăghicenoiu, Ruxandra, additional, Tudor, Ana Maria, additional, Vlad, Delia, additional, Petrea, Sorin, additional, Matei, Carina, additional, Oțelea, Dan, additional, Crăciun, Carmen, additional, Anghelina, Cristian, additional, Dumea, Elena, additional, Rugină, Sorin, additional, Petcu, Lucian Cristian, additional, Halichidis, Stela, additional, Cambrea, Simona Claudia, additional, Chiriac, Carmen, additional, Bodnar, Nina-Ioana, additional, Zaharia-Kezdi, Iringo-Erzsebet, additional, Gîrbovan, Cristina, additional, Incze, Andrea, additional, Georgescu, Anca Meda, additional, Panaitescu, Eugenia, additional, Cojocaru, Manole, additional, Laurențiu, Vochita, additional, Andreia, Vochita, additional, Radu, Opreanu, additional, Bogdan, Trinca, additional, Ovidiu, Rosca, additional, Iosif, Marincu, additional, Zamfir, Ramona, additional, Angelescu, Alina, additional, Popa, Alena Andreea, additional, Gavriliu, Liana, additional, Popa, Alena-Andreea, additional, Ducu, Georgeta, additional, Camburu, Daniela, additional, Cozma, Alina, additional, Podani, Manuela, additional, Dumitriu, Roxana, additional, Cupșa, Augustin, additional, Ionescu, Loredana, additional, Abagiu, Adrian Octavian, additional, Stoica, Loredana Nicoleta, additional, Blaga, Catrinel, additional, Koulosousas, Archontis, additional, Ștefănescu, Roxana, additional, Atomoaie, Alice, additional, Paraschiv, Florentina, additional, Duna, Florin Matache, additional, Olteanu, Rodica, additional, Ion, Roxana, additional, Zota, Alexandra, additional, Jaballah, Isra Ennour, additional, Mahfoud, Lara, additional, Preda, Georgeta, additional, Constantin, Magda, additional, Nicolae, Ilinca, additional, Ene, Corina Daniela, additional, Mitran, Mădălina Irina, additional, Benea, Vasile, additional, Tampa, Mircea, additional, Georgescu, Simona Roxana, additional, Bodoșca, Iulia Cristina, additional, Aramă, Sorin, additional, Caramăngiu, Iuliana, additional, Rosca, Ovidiu, additional, Cialma, Monica, additional, Opreanu, Radu, additional, Vochita, Laurențiu, additional, Murărescu, Vlad, additional, Palaghiță, Marilena, additional, Camburu, Cornel, additional, Duşan, Irina, additional, Bîrlad, Andreea, additional, Miron, Victor Daniel, additional, Drăgănescu, Anca Cristina, additional, Pițigoi, Daniela, additional, Luminos, Monica Luminița, additional, Șchiopu, Sabina, additional, Vasile, Magda, additional, Ionică, Mihaela, additional, Stăncescu, Adina, additional, Popescu, Cristina Elena, additional, Marin, Luminița, additional, Zaharia, Diana, additional, Dumitrescu, Cristina, additional, Tudor, Lucia, additional, Negulescu, Cristina, additional, Caliman-Sturdza, Olga Adriana, additional, Roșculeț, Cleo, additional, Manu, Bogdana, additional, Vaduva-Enoiu, Ana, additional, Lazureanu, Voichita Elena, additional, Niță, Elena-Violeta, additional, Dumitru, Sînziana, additional, Negru, Anca Ruxandra, additional, Ionescu, Ligia, additional, Ion, Liliana, additional, Neacșu, Marioara, additional, Mitran, Cristina Iulia, additional, Pribac, George Ciprian, additional, Prisca, Mirandolina, additional, Ursoiu, Fulvia, additional, Neamtu, Carmen, additional, Totolici, Bogdan, additional, Cotoraci, Coralia, additional, Ardelean, Aurel, additional, Albu, Simona Elena, additional, Carsote, Mara, additional, Miclăuș, Beatrice, additional, Mihai, Diana, additional, Vasiliu, Cristina, additional, Gorgoi, Corina, additional, Blescun, Amelia, additional, Breaza, Gelu, additional, Vintila, Sabina, additional, Mihai, Felicia, additional, Omer, Meilin, additional, Dragan, Cornel, additional, Pitigoi, Daniela, additional, Ciucu, Mirela, additional, Ionescu, Marius-Dan, additional, Roskanovic, Cristina, additional, Barbu, Valentina, additional, Zamfir, Ramona-Alexandra, additional, Dumitru, Alexandra-Sînziana, additional, Ispas, Viorica, additional, Leahu, Diana Oana, additional, Safta, Cristina Maria, additional, Benea, Mihaela Anca, additional, Munteanu, Octavian, additional, Bohâlțea, Roxana, additional, Trașcă, Livia, additional, Cîrstoiu, Monica, additional, Georgescu, Mădălina, additional, Ivanciuc, Alina Elena, additional, Lazar, Mihaela, additional, Ionescu, Teodora, additional, Cherciu, Carmen Maria, additional, Țecu, Cristina, additional, Mihai, Maria Elena, additional, Nițescu, Maria, additional, Azamfire, Delia, additional, Dumitrescu, Aura, additional, Ianosik, Elena, additional, Leca, Daniela, additional, Duca, Elena, additional, Bejan, Codrina, additional, Ceaușu, Emanoil, additional, Florescu, Simin-Aysel, additional, Popescu, Corneliu, additional, Târdei, Grațiela, additional, Juganariu, Codrina, additional, Lupulescu, Emilia, additional, Rodina, Ligia, additional, Cocuz, Maria Elena, additional, Stoian, Andreea, additional, Ionica, Mihaela, additional, Benea, Otilia-Elisabeta, additional, Sîrbu, Maria-Cristina, additional, Dobrotă, AnaMaria, additional, Duda, Roxana, additional, Dragomirescu, Cristiana Cerasella, additional, Fendrihan, Sergiu, additional, Scortan, Ecaterina, additional, Popescu, Corneliu P., additional, Benea, Șerban N., additional, Petcu, Andra E., additional, Podea, Iuliana A., additional, Jipa, Raluca E., additional, Hrișcă, Raluca M., additional, Nica, Manuela, additional, Merișor, Simona, additional, Nicolae, Cristian M., additional, Florescu, Simin A., additional, Dumitru, Irina M., additional, Moroti, Ruxandra V., additional, Nițescu, Bogdan, additional, Mustaţă, Iulia Monica, additional, Boldeanu, Sorina Claudia, additional, Furtunescu, Florentina, additional, Gheorghe, Mihaela, additional, Slavcovici, Adriana, additional, Tripon, Raluca, additional, Iubu, Roxana, additional, Marcu, Cristian, additional, Sabou, Mihaela, additional, Muntean, Monica, additional, Chiriac, Ion, additional, Tazlavanu, Liviu, additional, Cernat, Roxana, additional, Iringo, Kezdi, additional, Vâță, Andrei, additional, Arbune, Manuela, additional, Moisil, Teodora, additional, Ene, Corina-Daniela, additional, Georgescu, Roxana Simona, additional, Ene, Cosmin-Victor, additional, Ciortea, Marilena, additional, Dulgheru, Lucreția, additional, Luca, Mihaela Cătălina, additional, Harja-Alexa, Ioana-Alina, additional, Nemescu, Roxana, additional, Popazu, Mădălina, additional, Luca, Andrei Ștefan, additional, Bancescu, Gabriela, additional, Dabu, Bogdan, additional, Bancescu, Adrian, additional, Ilie, Adina Elena, additional, Pohrib, Săftica-Mariana, additional, Tache, Maria-Sabina, additional, Iliescu, Ion Aurel, additional, Tecu, Cristina, additional, Mihai, Maria-Elena, additional, Lazăr, Mihaela, additional, Cherciu, Carmen, additional, Ivanciuc, Alina, additional, Paliu, Mirela, additional, Curescu, Manuela, additional, Cerbu, Bianca, additional, Bunescu, Irina, additional, Pasnin, Ana, additional, Semeniuc, Stela, additional, and Popovici, Raisa, additional

Published
2016
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41. IMPACT OF SURGICAL APPROACH ON IMMEDIATE AND LONGTERM RESULTS FOR PATIENTS WITH ADVANCED LOCAL ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA.

Author

Marica, C., Bîrlă, Rodica, Marica, Raluca, Panaitescu, Eugenia, Carstocea, Laura, and Constantinoiu, S.

Subjects
ESOPHAGOGASTRIC junction, ADENOCARCINOMA, SURGICAL complications, SURVIVAL analysis (Biometry)
Abstract

Due to the localization of these tumors at the border between the stomach and the esophagus, the optimal surgical strategy for patients with adenocarcinoma of the esophagus junction is controversial. Evaluation of the influence of surgical approach on immediate and longterm results for patients with adenocarcinoma of esophagogastric junction. Between 2010-2017, 62 patients with locally advanced gastroesophageal junction adenocarcinomas were treated at St. Mary Hospital. The surgical approach was: abdominal in 40 patients -- mainly for patients with Siewert type III - 72.5%. Other types of surgical approach: abdominocervical in 4 patients, abdominothoracic - 5 patients, triple approach in 5 patients were mainly used for patients with Siewert type I (11 patients). Patients with Siewert type II had either abdominal (11 patients) or combined (7 patients). Postoperative morbidity was 46.77%. Anastomotic fistula occurred in 17 patients as follow: after abdominal approach in 10 patients, 2 patients after abdomino cervical approach, 2 patients after abdominothoracic approach, and 3 patients after triple approach. Postoperative mortality was 4.8%. The late complications were anastomotic stenosis in 14 patients. Anastomotic tumor recurrence was diagnosed in 7 patients. Survival analysis shows different survival curves in the way that the abdominocervical approach led to a reduced survival rate: 0% at 24 months, while the triple approach recorded a superior survival, 50% at 5 years. Intermediate curves I noticed after abdominal approach with 52.56% survival rate and 46.2% for abdominothoracic approach. Patients operated using abdominal approach had a significantly different mortality compared to patients operated by combined approach. The surgical approach did not influence the occurrence of postoperative complications - anastomotic fistula, fistula severity or pulmonary complications. [ABSTRACT FROM AUTHOR]

Published
2018

42. Immunologic Diagnosis of Neurotuberculosis

Author

Banica Dorina, Cojocaru Manole, Iacob Simona Alexandra, Iacob Diana Gabriela, Panaitescu Eugenia, and Radu Irina

Subjects
medicine.medical_specialty, Diagnostic methods, Tuberculosis, business.industry, Mycobacterial culture, Gold standard (test), Diagnostic tools, medicine.disease, Smear microscopy, Immunologic Diagnosis, medicine, High incidence, Intensive care medicine, business
Abstract

Tuberculosis (TB) is one of the most prevalent infectious diseases in the world, particularly in developing countries. The high incidence and mortality of TB in these countries mainly resides in the limited financial resources, the emergence of multiresistant strains and the spread of HIV infections. The key element for controlling TB is a rapid and early diagnosis which ensures the correct treatment and eradication of the infection source in the community. Current strategies for the development of a rapid and accurate diagnosis address 3 major objectives: improving the present diagnostic tools through better knowledge, developing new tests and increasing the accessibility to such diagnostic possibilities (Who Strategic Directions, 2006). The gold standard of diagnosis in TB is the identification of mycobacteria in the pathologic product using acid-fast smear microscopy and mycobacterial culture. Nevertheless the bacteriologic diagnosis is presently inefficient due to increasing number of smear-negative TB forms. This has led to the development of various complementary diagnostic methods such immunologic assays. The aim of the present chapter is to outline the literature data on the importance of the immunologic diagnosis in neurotuberculosis, a lethal localization of TB. It presents the current immunological assays and their practical value in the diagnosis of neurotuberculosis as complementary methods.

Published
2012

49. Immunologic Diagnosis of Neurotuberculosis

Author

Iacob Simona Alexandra, Banica Dorina, Iacob Diana Gabriela, Panaitescu Eugenia, Radu Irina, Cojocaru Manole, Iacob Simona Alexandra, Banica Dorina, Iacob Diana Gabriela, Panaitescu Eugenia, Radu Irina, and Cojocaru Manole

Published
2012
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