1. Matrix-Induced Autologous Chondrocyte Implantation
- Author
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Panagoitis D. Gikas, Johnston L, Timothy W. R. Briggs, and Faimali M
- Subjects
Materials science ,medicine.anatomical_structure ,Subchondral bone ,medicine ,Matrix (biology) ,Autologous chondrocyte implantation ,Fibrin glue ,Chondrocyte ,Biomedical engineering - Abstract
Chondral injuries are common in the knee. The use of chondrocyte implantation as a treatment began in the 1970s and has progressed through several generations. The third-generation technique, matrix-induced autologous chondrocyte implantation (MACI), involves suspending cultured chondrocytes in a type I/III collagen bilayer which is then fixed to the defect using fibrin glue. Current pre- and post-operative management is similar to that used with traditional autologous chondrocyte implantation (ACI). Research into clinical and histological outcomes following MACI is ongoing but initial results appear encouraging.
- Published
- 2014
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