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292 results on '"Pan, Yunbao"'

1. Dynamic Elite Individual Setting Based Heterogeneous Comprehensive Learning Particle Swarm Optimization

Author

Zhou, Tianwei, Zhang, Yulong, Pan, Yunbao, Yue, Guanghui, Niu, Ben, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Huang, De-Shuang, editor, Zhang, Xiankun, editor, and Pan, Yijie, editor

Published
2024
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32. Novel approach by natural language processing for COVID-19 knowledge discovery

Author

Wang, Li, primary, Jiang, Lei, additional, Pan, Dongyan, additional, Wang, Qinghua, additional, Yin, Zeyu, additional, Kang, Zijian, additional, Tian, Haoran, additional, Geng, Xuqiang, additional, Shao, Jinsong, additional, Pan, Wenjie, additional, Yin, Jian, additional, Fang, Li, additional, Wang, Yue, additional, Zhang, Weide, additional, Li, Zhixiu, additional, Zheng, Jun, additional, Hu, Wenxin, additional, Pan, Yunbao, additional, Yu, Dong, additional, Guo, Shicheng, additional, Lu, Wei, additional, Li, Qiang, additional, Zhou, Yunyun, additional, and Xu, Huji, additional

Published
2022
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35. Identification of lncRNA Signature of Tumor-Infiltrating T Lymphocytes With Potential Implications for Prognosis and Chemotherapy of Head and Neck Squamous Cell Carcinoma

Author

Wang, Liping, Yang, Gui, Liu, Guohong, and Pan, Yunbao

Subjects
Pharmacology, tumor-infiltrating T lymphocytes, tumor microenvironment, Pharmacology (medical), long noncoding RNAs, immunotherapy, Therapeutics. Pharmacology, RM1-950, head and neck squamous cell carcinoma
Abstract

Purpose: We systematically analyzed HNSCC-infiltrating T lymphocytes lncRNAs (HILTlncRNAs) to assess their predictive value for the survival outcome and immunotherapy response of patients with anti-programmed death-1 (PD-1) therapy and to evaluate their predictive power to chemotherapeutic agents.Methods: HNSCC transcriptome and clinical information was obtained from The Cancer Genome Atlas (TCGA) database. Immunocell microarray data were obtained from the Gene Expression Omnibus (GEO) database. T-cell-specific lncRNAs were identified by differential expression analysis. Prognostic paired HILTlncRNAs (PHILTlncRNAs) were filtered and modeled by univariate cox, lasso and multivariate cox regression analysis. To construct lncRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) regulatory networks, differentially expressed mRNAs in HNSCC patients were incorporated, microRNAs and differentially expressed mRNAs interacting with T-cell-specific lncRNAs were filtered out based on miRcode, miRDB, miRTarBase, and TargetScan databases.Results: 75 T-cell-specific lncRNAs and 9 prognostic PHILTlncRNAs were identified. Low-risk HNSCC patients had a better prognosis and significant immune cell infiltration, driving the immune response. Differential expression of RNA-binding proteins (RBPs), PD-1 and programmed cell death 1 ligand 1 (PD-L1) was demonstrated in the high and low risk groups of HNSCC patients. In the high risk group, high expression of PD-1 improved patient prognosis, whereas the opposite was observed in the low-risk group. The promoter methylation levels of two RBPs (DNMT1 and ZC3H12D) were decreased in HNSCC patients compared with normal samples, their expression levels were positively correlated with PD-1 and PD-L1 levels and T-cell infiltration. Finally, we screened the sensitivity of HNSCC patients to chemotherapeutic agents and found it differed between high and low risk groups.Conclusion: HILTlncRNAs provided a theoretical basis for immune targeted therapy and drug development.

Published
2022

37. The third inactivated vaccine booster dramatically enhanced SARS‐CoV‐2 antibody responses and did not influence the profile of prothrombotic antibody.

Author

Pan, Yunbao, Wang, Shilin, Liu, Guohong, Wang, Liping, Yang, Liu, Zeng, Xiaojiao, Qian, Chungen, Lin, Jun, Pan, Zhenyu, and Li, Yirong

Subjects
ANTIBODY formation, BOOSTER vaccines, SARS-CoV-2, HOSPITAL medical staff, PHOSPHOLIPID antibodies
Abstract

The purpose of this study is to investigate the production of both severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)‐specific antibodies and autoantibodies in serum following the third booster vaccination of the inactivated COVID‐19 vaccine, and to study the effect of B cell subsets with CD27 and CD38 phenotypes in peripheral blood on antibody production. Routine blood indexes, SARS‐CoV‐2 antibodies, platelet factor 4 and seven antiphospholipid antibodies were detected both before and 2 months after vaccination in the medical staff of the Zhongnan Hospital of Wuhan University. Peripheral blood B cell subtypes were detected before vaccination. Following immunization, the positive rate of anti‐N‐S1 immunoglobulin (IgG) had increased from 24.8% to 91.3% and the average antibody concentration had increased by 11 times. The positive rate of neutralizing antibody had increased from 24.8% to 91.3%, the average antibody concentration had increased by 12 times, and the primary increased anti‐S1 IgG subtype was that of IgG1. Peripheral blood CD27 + CD38+ B cells were positively correlated with antibody levels after vaccination and were a predictor of the antibody response. In addition, although some indicators showed slight absolute changes, the blood parameters and antiphospholipid antibodies of most volunteers were normal both before and after COVID‐19 inactivated vaccine inoculation, and there was no statistical difference in abnormal rates either before or after inoculation. Antibodies in vivo were increased after vaccination with the inactivated vaccine, and IgG1 was the main subtype involved in response to the vaccine. Vaccination with the inactivated COVID‐19 vaccine did not appear to affect thrombus‐related autoantibodies. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Prognosis and antibody profiles in survivors of critical illness from COVID-19: a prospective, multi-centre, cohort study

Author

Yang, Xiao, primary, Li, Zhifeng, additional, Wang, Binbin, additional, Pan, Yunbao, additional, Jiang, Chaoyun, additional, Zhang, Xingguo, additional, Yang, Yadong, additional, Zhou, Chenliang, additional, Hu, Chang, additional, Zhang, Zhijiang, additional, Xu, Haibo, additional, Liao, Weijin, additional, Vizcaychipi, Marcela P., additional, Sanders, Robert D., additional, Li, Yirong, additional, Ma, Daqing, additional, and Peng, Zhiyong, additional

Published
2021
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41. SARS-CoV-2-specific immune response in COVID-19 convalescent individuals

Author

Chungen Qian, Liangjun Chen, Xiaojiao Zeng, Guohong Liu, Fangming Cheng, Li Yirong, Jun Lin, Liu Yang, Pan Yunbao, Yueting Tang, Xianghu Jiang, Xinghuan Wang, and Xinming Wang

Subjects
Adult, Male, 0301 basic medicine, Cancer Research, Cellular immunity, QH301-705.5, T cell, Antibodies, Viral, Article, Immunoglobulin G, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Antigen, Genetics, medicine, Humans, 030212 general & internal medicine, Biology (General), Neutralizing antibody, Immunological disorders, Aged, Aged, 80 and over, Immunity, Cellular, biology, business.industry, COVID-19, Correction, Convalescence, Middle Aged, Acquired immune system, Antibodies, Neutralizing, Lymphocyte Subsets, Immunity, Humoral, 030104 developmental biology, medicine.anatomical_structure, Immunology, biology.protein, Medicine, Cytokines, Infectious diseases, Female, Antibody, business, CD8
Abstract

We collected blood from coronavirus disease 2019 (COVID-19) convalescent individuals and investigated SARS-CoV-2-specific humoral and cellular immunity in these discharged patients. Follow-up analysis in a cohort of 171 patients at 4–11 months after the onset revealed high levels of IgG antibodies. A total of 78.1% (164/210) of the specimens tested positive for neutralizing antibody (NAb). SARS-CoV-2 antigen peptide pools-stimulated-IL-2 and -IFN-γ response can distinguish COVID-19 convalescent individuals from healthy donors. Interestingly, NAb survival was significantly affected by the antigen peptide pools-stimulated-IL-2 response, -IL-8 response, and -IFN-γ response. The antigen peptide pools-activated CD8+ T cell counts were correlated with NAb. The antigen peptide pools-activated natural killer (NK) cell counts in convalescent individuals were correlated with NAb and disease severity. Our data suggested that the development of NAb is associated with the activation of T cells and NK cells. Our work provides a basis for further analysis of the protective immunity to SARS-CoV-2 and for understanding the pathogenesis of COVID-19. It also has implications for the development of an effective vaccine for SARS-CoV-2 infection.

Published
2021

44. Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity

Author

Tang, Yueting, primary, Sun, Jiayu, additional, Pan, Huaqin, additional, Yao, Fen, additional, Yuan, Yumeng, additional, Zeng, Mi, additional, Ye, Guangming, additional, Yang, Gui, additional, Zheng, Bokun, additional, Fan, Junli, additional, Pan, Yunbao, additional, Zhao, Ziwu, additional, Guo, Shuang, additional, Liu, Yinjuan, additional, Liao, Fanlu, additional, Duan, Yongwei, additional, Jiao, Xiaoyang, additional, and Li, Yirong, additional

Published
2021
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