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15 results on '"Pan, Shandong"'

5. Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population

Author

Chen, Jiaping, Qin, Zhenzhen, Pan, Shandong, Jiang, Jie, Liu, Li, Liu, Jibin, Chen, Xiaojun, Hu, Zhibin, and Shen, Hongbing

Subjects
Original Article
Abstract

Recent evidence indicates that dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Based on the important role of miRNA biogenesis genes in carcinogenesis, we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.We identified three single nucleotide polymorphisms (SNPs) located in the 3'-untranslated regions (3'-UTR) of of miRNA biogenesis key genes (rs1057035 in DICER, rs3803012 in RAN and rs10773771 in HIWI) and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and 1,549 cancer-free controls in Chinese women.Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk [rs3803012 in RAN AG/GG vs. AA adjusted OR =1.104, 95% confidence interval (CI): 0.859-1.419; rs1057035 in DICER CT/CC vs. TT adjusted OR =0.962, 95% CI: 0.805-1.149; rs10773771 in HIWI CT/CC vs. TT adjusted OR =0.963, 95% CI: 0.826-1.122].The findings did not suggest that genetic variants in the 3'-UTR of RAN, DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population.

Published
2013

6. Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

Author

Hu, Zhibin, primary, Li, Zheng, additional, Yu, Jun, additional, Tong, Chao, additional, Lin, Yuan, additional, Guo, Xuejiang, additional, Lu, Feng, additional, Dong, Jing, additional, Xia, Yankai, additional, Wen, Yang, additional, Wu, Hao, additional, Li, Honggang, additional, Zhu, Yong, additional, Ping, Ping, additional, Chen, Xiangfeng, additional, Dai, Juncheng, additional, Jiang, Yue, additional, Pan, Shandong, additional, Xu, Peng, additional, Luo, Kailing, additional, Du, Qiang, additional, Yao, Bing, additional, Liang, Ming, additional, Gui, Yaoting, additional, Weng, Ning, additional, Lu, Hui, additional, Wang, Zhuqing, additional, Zhang, Fengbin, additional, Zhu, Xiaobin, additional, Yang, Xiaoyu, additional, Zhang, Zhou, additional, Zhao, Han, additional, Xiong, Chenliang, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Chen, Feng, additional, Xu, Jianfeng, additional, Wang, Xinru, additional, Zhou, Zuomin, additional, Chen, Zi-Jiang, additional, Liu, Jiayin, additional, Shen, Hongbing, additional, and Sha, Jiahao, additional

Published
2014
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7. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

Author

Shi, Yongyong, primary, Li, Li, additional, Hu, Zhibin, additional, Li, Shuang, additional, Wang, Shixuan, additional, Liu, Jihong, additional, Wu, Chen, additional, He, Lin, additional, Zhou, Jianfeng, additional, Li, Zhiqiang, additional, Hu, Ting, additional, Chen, Yile, additional, Jia, Yao, additional, Wang, Shaoshuai, additional, Wu, Li, additional, Cheng, Xiaodong, additional, Yang, Zhijun, additional, Yang, Ru, additional, Li, Xiong, additional, Huang, Kecheng, additional, Zhang, Qinghua, additional, Zhou, Hang, additional, Tang, Fangxu, additional, Chen, Zhilan, additional, Shen, Jian, additional, Jiang, Jie, additional, Ding, Hu, additional, Xing, Hui, additional, Zhang, Shulan, additional, Qu, Pengpeng, additional, Song, Xiaojie, additional, Lin, Zhongqiu, additional, Deng, Dongrui, additional, Xi, Ling, additional, Lv, Weiguo, additional, Han, Xiaobing, additional, Tao, Guangshi, additional, Yan, Lixing, additional, Han, Zhedong, additional, Li, Zhuang, additional, Miao, Xiaoping, additional, Pan, Shandong, additional, Shen, Yuanming, additional, Wang, Hui, additional, Liu, Dan, additional, Gong, Ee, additional, Li, Zheng, additional, Zhou, Limei, additional, Luan, Xiaomei, additional, Wang, Chuping, additional, Song, Qian, additional, Wu, Sufang, additional, Xu, Hongbin, additional, Shen, Jiawei, additional, Qiang, Fulin, additional, Ma, Gang, additional, Liu, Li, additional, Chen, Xiaojun, additional, Liu, Jibin, additional, Wu, Jiangping, additional, Shen, Yan, additional, Wen, Yang, additional, Chu, Minjie, additional, Yu, Jiang, additional, Hu, Xiaoxia, additional, Fan, Yujuan, additional, He, Hongying, additional, Jiang, Yanming, additional, Lei, Zhiying, additional, Liu, Cui, additional, Chen, Jianhua, additional, Zhang, Yuan, additional, Yi, Cunjian, additional, Chen, Shuangyun, additional, Li, Wenjin, additional, Wang, Daowen, additional, Wang, Zehua, additional, Di, Wen, additional, Shen, Keng, additional, Lin, Dongxin, additional, Shen, Hongbing, additional, Feng, Youji, additional, Xie, Xing, additional, and Ma, Ding, additional

Published
2013
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8. A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations

Author

Hu, Zhibin, primary, Shi, Yongyong, additional, Mo, Xuming, additional, Xu, Jing, additional, Zhao, Bijun, additional, Lin, Yuan, additional, Yang, Shiwei, additional, Xu, Zhengfeng, additional, Dai, Juncheng, additional, Pan, Shandong, additional, Da, Min, additional, Wang, Xiaowei, additional, Qian, Bo, additional, Wen, Yang, additional, Wen, Juan, additional, Xing, Jinliang, additional, Guo, Xuejiang, additional, Xia, Yankai, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Yu, Shiqiang, additional, Liu, Jiayin, additional, Zhou, Zuomin, additional, Wang, Xinru, additional, Chen, Yijiang, additional, Sha, Jiahao, additional, and Shen, Hongbing, additional

Published
2013
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9. Genetic Variants at 6p21.1 and 7p15.3 Are Associated with Risk of Multiple Cancers in Han Chinese

Author

Jin, Guangfu, primary, Ma, Hongxia, additional, Wu, Chen, additional, Dai, Juncheng, additional, Zhang, Ruyang, additional, Shi, Yongyong, additional, Lu, Jiachun, additional, Miao, Xiaoping, additional, Wang, Meilin, additional, Zhou, Yifeng, additional, Chen, Jiaping, additional, Li, Huizhang, additional, Pan, Shandong, additional, Chu, Minjie, additional, Lu, Feng, additional, Yu, Dianke, additional, Jiang, Yue, additional, Dong, Jing, additional, Hu, Lingmin, additional, Chen, Yijiang, additional, Xu, Lin, additional, Shu, Yongqian, additional, Pan, Shiyang, additional, Tan, Wen, additional, Zhou, Baosen, additional, Lu, Daru, additional, Wu, Tangchun, additional, Zhang, Zhengdong, additional, Chen, Feng, additional, Wang, Xinru, additional, Hu, Zhibin, additional, Lin, Dongxin, additional, and Shen, Hongbing, additional

Published
2012
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10. GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers

Author

Li, Shengping, primary, Qian, Ji, additional, Yang, Yuan, additional, Zhao, Wanting, additional, Dai, Juncheng, additional, Bei, Jin-Xin, additional, Foo, Jia Nee, additional, McLaren, Paul J., additional, Li, Zhiqiang, additional, Yang, Jingmin, additional, Shen, Feng, additional, Liu, Li, additional, Yang, Jiamei, additional, Li, Shuhong, additional, Pan, Shandong, additional, Wang, Yi, additional, Li, Wenjin, additional, Zhai, Xiangjun, additional, Zhou, Boping, additional, Shi, Lehua, additional, Chen, Xinchun, additional, Chu, Minjie, additional, Yan, Yiqun, additional, Wang, Jun, additional, Cheng, Shuqun, additional, Shen, Jiawei, additional, Jia, Weihua, additional, Liu, Jibin, additional, Yang, Jiahe, additional, Wen, Zujia, additional, Li, Aijun, additional, Zhang, Ying, additional, Zhang, Guoliang, additional, Luo, Xianrong, additional, Qin, Hongbo, additional, Chen, Minshan, additional, Wang, Hua, additional, Jin, Li, additional, Lin, Dongxin, additional, Shen, Hongbing, additional, He, Lin, additional, de Bakker, Paul I. W., additional, Wang, Hongyang, additional, Zeng, Yi-Xin, additional, Wu, Mengchao, additional, Hu, Zhibin, additional, Shi, Yongyong, additional, Liu, Jianjun, additional, and Zhou, Weiping, additional

Published
2012
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15. Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population.

Author

Chen J, Qin Z, Pan S, Jiang J, Liu L, Liu J, Chen X, Hu Z, and Shen H

Abstract

Objective: Recent evidence indicates that dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Based on the important role of miRNA biogenesis genes in carcinogenesis, we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer., Methods: We identified three single nucleotide polymorphisms (SNPs) located in the 3'-untranslated regions (3'-UTR) of of miRNA biogenesis key genes (rs1057035 in DICER, rs3803012 in RAN and rs10773771 in HIWI) and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and 1,549 cancer-free controls in Chinese women., Results: Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk [rs3803012 in RAN AG/GG vs. AA adjusted OR =1.104, 95% confidence interval (CI): 0.859-1.419; rs1057035 in DICER CT/CC vs. TT adjusted OR =0.962, 95% CI: 0.805-1.149; rs10773771 in HIWI CT/CC vs. TT adjusted OR =0.963, 95% CI: 0.826-1.122]., Conclusions: The findings did not suggest that genetic variants in the 3'-UTR of RAN, DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population.

Published
2013
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