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165 results on '"Pan, Mingxin"'

20. Plasma-only circulating tumor DNA analysis detects minimal residual disease and predicts early relapse in hepatocellular carcinoma patients undergoing curative resection

Author

Xu, Yuyan, primary, Cai, Jianpeng, additional, Zhong, Kaihang, additional, Wen, Yaohong, additional, Cai, Lei, additional, He, Guolin, additional, Liao, Hangyu, additional, Zhang, Cheng, additional, Fu, Shunjun, additional, Chen, Tingting, additional, Cai, Jinping, additional, Zhong, Xuefeng, additional, Chen, Chunzhu, additional, Huang, Mengli, additional, Cheng, Yuan, additional, and Pan, Mingxin, additional

Published
2023
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26. Case report: Primary hepatocellular carcinoma with portal vein tumor thrombus characterized by active tumor immune microenvironment achieving a complete response following treatment of combined immunotherapy

Author

Zhong, Kaihang, primary, Xu, Yuyan, additional, Cheng, Yuan, additional, Wen, Yaohong, additional, Cai, Lei, additional, He, Guolin, additional, Huang, Huakun, additional, Fu, Shunjun, additional, Zhong, Xuefeng, additional, Zheng, Yating, additional, Chen, Tingting, additional, Huang, Mengli, additional, and Pan, Mingxin, additional

Published
2022
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31. Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma.

Author

Fang, Yinghao, Xu, Yuyan, Liao, Wei, Ji, Tao, Yu, Linyuan, Li, Longhai, Pan, Mingxin, and Yang, Dinghua

Abstract

Nuclear receptor coactivator 6 (NCOA6), a coactivator of numerous nuclear receptors and transcription factors, regulates multiple critical cellular functions. Nuclear receptor coactivator 6 is dysregulated in various cancers, including hepatocellular carcinoma (HCC); however, its role remains largely unknown. Here we reported that NCOA6 was highly expressed in HCC compared to the adjacent liver tissue, and NCOA6 overexpression was significantly correlated with poor HCC prognosis. Experiments revealed that the knockdown of NCOA6 damaged the proliferation, migration, and invasion of HCC cells. Multiomics and immune infiltration analyses showed a close relationship between NCOA6 expression, multiple cancer‐related malignant pathways, and the immunosuppressive microenvironment. Finally, we established an effective NCOA6‐related microRNA (miRNA) signature to distinguish HCC from hepatitis\liver cirrhosis patients. To the best of our knowledge, this study is the first to provide a comprehensive analysis of NCOA6 expression in HCC. We found that NCOA6 plays an important role in HCC development and has a potential mechanism of action. Establishing an NCOA6‐related miRNA signature will help develop novel diagnostic strategies for HCC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Exosomal circ-RBM23 sponging miR-139-5p to promote liver regeneration through RRM2/AKT/mTOR pathway

Author

Shunjun Fu, He Guolin, Feng Lei, Lujia Wang, Honglei Zhu, Zeyi Guo, Pan Mingxin, Yi Gao, Yi Wang, Xiaoge Niu, Li Yang, Lin Zhou, Shao Li, Yu Fu, Yizhou Zheng, Ting Li, and Hangyu Liao

Subjects
business.industry, Cancer research, Medicine, business, Protein kinase B, PI3K/AKT/mTOR pathway, Liver regeneration, Mir 139 5p
Abstract

BackgroundExosomes are small nano-size membrane vesicles and are involved in intercellular interaction. Here, we examined if exosomes obtained from human placental stem cells promote liver regeneration after partial hepatectomy. MethodsExosomes generated from primary human placental stem cells were isolated and characterized. Cell co-culture model was used to clarify whether exosomes can induce hepatocytes proliferation in vitro . Partial hepatectomy mouse model was used to evaluate whether exosomes can promote hepatocytes proliferation in vivo . ResultsIt is found that human placental-derived stem cells exosomes (hPDSCs-exo) can induce hepatocyte proliferation in vitro and in vivo . Mechanistically, exosomal circ-RBM23 served as a ceRNA for miR-139-5p, regulated RRM2 and accelerated proliferation through AKT/mTOR pathways. Ablation of exosomal circ-RBM23 suppressed the proliferative effect of exosomes. ConclusionsThe hPMSCs exosomal circ-RBM23 stimulated cell proliferation and liver regeneration after 70% partial hepatectomy by regulated RRM2. Our findings highlight a potential novel therapeutic avenue for liver regeneration after hepatectomy.

Published
2021
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33. Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening

Author

Liao, Wei, primary, Yang, Wanren, additional, Xu, Jiecheng, additional, Yan, Zhengming, additional, Pan, Mingxin, additional, Xu, Xiaoping, additional, Zhou, Shuqin, additional, Zhu, Yu, additional, Lan, Jianqiang, additional, Zeng, Min, additional, Han, Xu, additional, Li, Shao, additional, Li, Yang, additional, Liang, Kangyan, additional, Gao, Yi, additional, and Peng, Qing, additional

Published
2021
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34. Exosomal circ-RBM23 sponging miR-139-5p to promote liver regeneration through RRM2/AKT/mTOR pathway

Author

He, Guolin, primary, Fu, Yu, additional, Guo, Zeyi, additional, Zhu, Honglei, additional, Feng, Lei, additional, Liao, Hangyu, additional, Niu, Xiaoge, additional, Wang, Yi, additional, Zhou, Lin, additional, Fu, Shunjun, additional, Li, Yang, additional, Li, Shao, additional, Wang, Lujia, additional, Zheng, Yizhou, additional, Pan, Mingxin, additional, Li, Ting, additional, and Gao, Yi, additional

Published
2021
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36. Co-amplification of genes in chromosome 8q24: a robust prognostic marker in hepatocellular carcinoma

Author

Zheng, Yongjian, primary, Cheng, Yuan, additional, Zhang, Cheng, additional, Fu, Shunjun, additional, He, Guolin, additional, Cai, Lei, additional, Qiu, Ling, additional, Huang, Kunhua, additional, Chen, Qunhui, additional, Xie, Wenzhuan, additional, Chen, Tingting, additional, Huang, Mengli, additional, Bai, Yuezong, additional, and Pan, Mingxin, additional

Published
2021
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37. Co-amplification of Genes in Chromosome 8q24: a Robust Prognostic Marker in Hepatocellular Carcinoma

Author

Cheng, Yuan, primary, Zheng, Yongjian, additional, Zhang, Cheng, additional, Fu, Shunjun, additional, He, Guolin, additional, Cai, Lei, additional, Qiu, Ling, additional, Huang, Huakun, additional, Chen, Qunhui, additional, Xie, Wenzhuan, additional, Chen, Tingting, additional, Huang, Mengli, additional, Bai, Yuezong, additional, and Pan, Mingxin, additional

Published
2021
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38. Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-based Drug Screening

Author

Liao, Wei, primary, Yang, Wanren, additional, Zhang, Yue, additional, Zeng, Fanhong, additional, Xu, Jiecheng, additional, Yan, Zhengming, additional, Pan, Mingxin, additional, Xu, Xiaoping, additional, Zhou, Shuqin, additional, Zeng, Min, additional, Weng, Jun, additional, Han, Xu, additional, Li, Shao, additional, Li, Yang, additional, Liang, Kangyan, additional, Peng, Qing, additional, and Gao, Yi, additional

Published
2020
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39. TCGA and ESTIMATE data mining to identify potential prognostic biomarkers in HCC patients

Author

He, Guolin, primary, Fu, Shunjun, additional, Li, Yang, additional, Li, Ting, additional, Mei, Purong, additional, Feng, Lei, additional, Cai, Lei, additional, Cheng, Yuan, additional, Zhou, Chenjie, additional, Tang, Yujun, additional, Huang, Wenbin, additional, Liu, Haiyan, additional, Cen, Bohong, additional, Pan, Mingxin, additional, and Gao, Yi, additional

Published
2020
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43. Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis

Author

Jiang, Xinan, Feng, Lei, Pan, Mingxin, and Gao, Yi

Subjects
Article Subject
Abstract

Background. Liver allograft preservation frequently involves static cold storage (CS) and machine perfusion (MP). With its increasing popularity, we investigated whether MP was superior to CS in terms of beneficial outcomes. Methods. Human studies and large animal studies that optimized livers for transplantation using MP versus CS were assessed (PubMed/Medline/EMBASE). Meta-analyses were conducted for comparisons. Study quality was assessed according to the Newcastle-Ottawa quality assessment scale and SYRCLE’s risk of bias tool. Results. Nineteen studies were included. Among the large animal studies, lower levels of lactate dehydrogenase (SMD -3.16, 95% CI -5.14 to -1.18), alanine transferase (SMD -2.46, 95% CI -4.03 to -0.90), and hyaluronic acid (SMD -2.48, 95% CI -4.21 to -0.74) were observed in SNMP-preserved compared to CS-preserved livers. NMP-preserved livers showing lower level of hyaluronic acid (SMD -3.97, 95% CI -5.46 to -2.47) compared to CS-preserved livers. Biliary complications (RR 0.45, 95% CI 0.28 to 0.73) and early graft dysfunction (RR 0.56, 95% CI 0.34 to 0.92) also significantly reduced with HMP preservation in human studies. No evidence of publication bias was found. Conclusions. MP preservation could improve short-term outcomes after transplantation compared to CS preservation. Additional randomized controlled trials (RCTs) are needed to develop clinical applications of MP preservation.

Published
2018
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48. Efficacy and safety of ultrasound-guided continuous hyperthermic intraperitoneal perfusion chemotherapy for the treatment of malignant ascites: a midterm study of 36 patients

Author

Wu,Yinbing, Pan,Mingxin, Cui,Shuzhong, Ba,Mingchen, Chen,Zulong, Ruan,Qiang, Wu,Yinbing, Pan,Mingxin, Cui,Shuzhong, Ba,Mingchen, Chen,Zulong, and Ruan,Qiang

Abstract

Yinbing Wu,1,2 Mingxin Pan,1 Shuzhong Cui,2 Mingchen Ba,2 Zulong Chen,2 Qiang Ruan2 1Second Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, 2Treatment Center of Body Cavitary Thermo-Perfusion, Cancer Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of China Background: This study aimed to evaluate the efficacy and safety of ultrasound-guided continuous hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) for the treatment of malignant ascites (MA). Methods: Between July 2011 and June 2013, 36 MA patients were prospectively and consecutively hospitalized for three cycles of elective CHIPC under ultrasound guidance, maintained at a constant flow rate of 400–600 mL/min normal saline containing 5-fluorouracil plus mitomycin or carboplatin and at a constant temperature of 43°C±0.2°C, for 90 minutes. Main outcome measures were ascites resolution, Karnofsky performance status (KPS), and serum tumor biomarkers at 2 weeks after the last cycle of CHIPC. All the patients underwent uneventful CHIPC as scheduled, and vital signs remained stable over CHIPC. Results: At 2 weeks after the last cycle of CHIPC, MA completely and partially resolved in 26 (72.2%) patients and eight (22.2%) patients, respectively; mean KPS score increased from pretreatment 61±9 to posttreatment 76±9 (P<0.001), and serum carcinoembryonic antigen and carbohydrate antigens 12-5 and 19-9 significantly decreased (all P<0.01). Conclusion: The current study indicated that ultrasound-guided CHIPC is an effective and safe palliative treatment modality for MA with respect to MA resolution, patient’s general well-being, and systemic disease control. The long-term benefit of CHIPC on overall survival remains to be investigated in MA patients. Keywords: continuous hyperthermic intraperitoneal pe

Published
2016

50. Correlation Between Postoperative Early Recurrence of Hepatocellular Carcinoma and Mesenchymal Circulating Tumor Cells in Peripheral Blood.

Author

Zhong Wang, Lei Luo, Yuan Cheng, Guolin He, Bangjian Peng, Yi Gao, Ze-sheng Jiang, MingXin Pan, Wang, Zhong, Luo, Lei, Cheng, Yuan, He, Guolin, Peng, Bangjian, Gao, Yi, Jiang, Ze-Sheng, and Pan, MingXin

Subjects
LIVER cancer, CANCER cells, CANCER relapse, IN situ hybridization, FLUORESCENCE, COMPARATIVE studies, HEPATECTOMY, HEPATOCELLULAR carcinoma, LIVER tumors, RESEARCH methodology, MEDICAL cooperation, METASTASIS, PROGNOSIS, RESEARCH, RESEARCH funding, TIME, EVALUATION research
Abstract

Background: Circulating tumor cells (CTCs) have been actively studied for their functions in hepatocellular carcinoma (HCC) recurrence. However, the relationship between circulating tumor cells subtypes and hepatocellular carcinoma recurrence is still unclear.Methods: CTCs were collected from the peripheral blood of 62 postoperative HCC patients. The CTCs were isolated with a filtration-based method. Multiplex fluorescence in situ hybridization was used to characterize the CTCs based on mRNA expression levels of epithelial and mesenchymal markers.Results: Of the 62 HCC patients, 26 were diagnosed with early recurrence (ER) and 36 did not experience recurrence. Comparison between the recurrence group and the non-recurrence group showed the total number of CTCs, mesenchymal CTCs, and mixed CTCs in the recurrence group was significantly higher than in the non-recurrence group. Receiver operator characteristic (ROC) curve analysis was performed to define the positive cutoff values as follows: total number of CTCs ≥ 4, mesenchymal CTCs ≥ 1, and mixed CTCs ≥ 3. Analysis showed that portal vein tumor thrombus (hazard ratio [HR] = 2.905, P = 0.023) and mesenchymal CTC positivity (HR = 3.453, P = 0.007) were independent risk factors for ER. The correlation between the presence of mesenchymal CTCs and time to recurrence was further examined, and the results showed significantly shortened postoperative disease-free survival in patients positive for mesenchymal CTCs (P < 0.001).Conclusions: HCC patients with positive peripheral mesenchymal CTCs have a more serious risk of ER, which could be a potential biomarker in HCC prognosis monitoring. [ABSTRACT FROM AUTHOR]

Published
2018
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