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5. Neutrophil‐to‐Lymphocyte Ratio Positively Correlates to Age in Healthy Population

Author

Li, Jian, Chen, Qingyu, Luo, Xiaohong, Hong, Jun, Pan, Kunyi, Lin, Xianghua, Liu, Xiaoqiang, Zhou, Lijun, Wang, Han, Xu, Ying, Li, Hongyu, and Duan, Chaohui

Subjects
Adult, Male, Neutrophils, fungi, Age Factors, Blood Pressure, Original Articles, Middle Aged, Prognosis, Body Mass Index, Young Adult, Case-Control Studies, Humans, Disease, Female, Lymphocytes, Biomarkers, Aged, Follow-Up Studies
Abstract

BACKGROUND: Neutrophil to lymphocyte ratio (NLR) was reported to be an independent easy‐to‐measure marker for many diseases, while the distribution of NLR in healthy population was not formally studied. So we investigated NLR in healthy people in this study. METHODS: Data include NLR, systolic pressure, diastolic pressure, and body mass index (BMI), which were collected from 3,262 healthy population. Correlations of NLR with variables were analyzed with SPSS16.0. RESULTS: Results demonstrated that NLR was positively associated with age (P < 0.001). The eldest age group possessed the highest NLR and the youngest age group had the lowest NLR. NLR was also slightly positively associated with systolic pressure, diastolic pressure, and BMI (P < 0.001). CONCLUSION: Older people possessed relatively high NLR in healthy population.

Published
2014

6. Molecular epidemiology and characteristic of virulence gene of community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus isolates in Sun Yat-sen Memorial hospital, Guangzhou, Southern China

Author

Xie, Xiaoying, primary, Bao, Yunwen, additional, Ouyang, Nengyong, additional, Dai, Xinlu, additional, Pan, Kunyi, additional, Chen, Baiji, additional, Deng, Yawen, additional, Wu, Xiquan, additional, Xu, Fengqin, additional, Li, Hongyu, additional, and Huang, Songyin, additional

Published
2016
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7. Differences in Staphylococcus aureus nasal carriage and molecular characteristics among community residents and healthcare workers at Sun Yat-Sen University, Guangzhou, Southern China

Author

Chen, Baiji, primary, Dai, Xinlu, additional, He, Bo, additional, Pan, Kunyi, additional, Li, Hongyu, additional, Liu, Xiaoqiang, additional, Bao, Yunwen, additional, Lao, Weisi, additional, Wu, Xiquan, additional, Yao, Yandan, additional, and Huang, Songyin, additional

Published
2015
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10. Molecular epidemiology and characteristic of virulence gene of community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus isolates in Sun Yat-sen Memorial hospital, Guangzhou, Southern China.

Author

Xiaoying Xie, Yunwen Bao, Nengyong Ouyang, Xinlu Dai, Kunyi Pan, Baiji Chen, Yawen Deng, Xiquan Wu, Fengqin Xu, Hongyu Li, Songyin Huang, Xie, Xiaoying, Bao, Yunwen, Ouyang, Nengyong, Dai, Xinlu, Pan, Kunyi, Chen, Baiji, Deng, Yawen, Wu, Xiquan, and Xu, Fengqin

Subjects
METHICILLIN-resistant staphylococcus aureus, PUBLIC health, MICROBIAL sensitivity tests, MOLECULES, MICROBIAL virulence genetics, EPIDEMIOLOGY, NOSOCOMIAL infections, PHYSIOLOGY, HOSPITALS, MOLECULAR epidemiology, PULSED-field gel electrophoresis, STAPHYLOCOCCAL diseases, TOXINS, MICROBIAL virulence, COMMUNITY-acquired infections, SEQUENCE analysis
Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both hospital and community infections globally. It's important to illuminate the differences between community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA), but there have been confusions on the definition, especially for the MRSA isolates identified within 48 h of admission. This study aimed to determine the molecular characteristics and virulence genes profile of CA and HA-MRSA isolates identified less than 48 h after hospital admission in our region.Methods: A total 62 MRSA isolates identified within 48 h after admission and the clinical data were collected. Antimicrobial susceptibility test (AST) of collected isolates were performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI) 2015, and staphylococcal cassette chromosome mec (SCCmec) typing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and virulence gene profiling were performed to explore the molecular diversity.Results: SCCmec III and sequence type (ST) 239 were the most prevalent SCCmec type and ST in both CA and HA-MRSA groups. HA-MRSA group had higher prevalence of SCCmec III (87.2 %) and ST239 (79.5 %) compared with CA-MRSA (60.9 and 43.4 %, both P < 0.001), while the frequency of SCCmec IV (26.0 %) and ST59 (21.7 %) were higher in CA-MRSA than its counterpart (P < 0.001 and P = 0.003). MRSA-ST239-III was the predominant type in this study (61.3 %, 38/62), especially in HA-MRSA group (76.9 %, 30/39). However, CA-MRSA strains exhibited more diversity in genotypes in this study. Meanwhile, CA-MRSA tended to have lower resistant percentage to non-β-lactams antibiotics but more virulence genes carriage, especially the staphylococcal enterotoxins (SE) genes. Notably, seb gene was only detected in CA-MRSA isolates (52.2 %), likely a significant marker for CA-MRSA isolates. Panton-Valentine leukocidin gene (PVL) was highly detected in both groups, while appeared no significantly different between CA-MRSA (47.8 %) and HA-MRSA (43.6 %).Conclusions: Our findings support a difference in the molecular epidemiology and virulence genes profile of CA-MRSA and HA-MRSA. Furthermore, this study indicates a possible transmission from HA-MRSA to CA-MRSA, which may cause the overlap of the definition. [ABSTRACT FROM AUTHOR]

Published
2016
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