Search

Your search keyword '"Palvarini, Loredana"' showing total 19 results
Start Over Author "Palvarini, Loredana"
19 results on '"Palvarini, Loredana"'

2. Prevalence of acquired resistance mutations in a large cohort of perinatally infected HIV-1 patients

Author

Giacometti, Andrea, Butini, Luca, del Gobbo, Romana, Bagnarelli, Patrizia, Tacconi, Danilo, Corbelli, Giovanni, Zanussi, Stefania, Monno, Laura, Punzi, Grazia, Maggiolo, Franco, Calza, Leonardo, Carla Re, Maria, Pristera, Raffaele, Turconi, Paola, Mandas, Antonella, Tini, Sauro, Zoncada, Alessia, Paolini, Elisabetta, Amadio, Giorgio, Sighinolfi, Laura, Corsi, Paola, Galli, Luisa, Di Pietro, Massimo, Colao, Grazia, Tosti, Andrea, Setti, Maurizio, Bruzzone, Bianca, Di Biagio, Antonio, Cenderello, Giovanni, Trezzi, Michele, Orani, Anna, Arcidiacono, Irene, Degiuli, Alberto, De Gennaro, Michele, Chiodera, Alessandro, Scalzini, Alfredo, Palvarini, Loredana, Todaro, Giovanni, Rusconi, Stefano, Gismondo, Maria Rita, Micheli, Valeria, Biondi, Maria Luisa, Capetti, Amedeo, Meraviglia, Paola, Boeri, Enzo, Mussini, Cristina, Pecorari, Monica, Soria, Alessandro, Vecchi, Laura, Santirocchi, Maurizio, Brustia, Diego, Ravanini, Paolo, Dal Bello, Federico, Romano, Nino, Mancuso, Salvatrice, Calzetti, Carlo, Maserati, Renato, Filice, Gaetano, Baldanti, Fausto, Francisci, Daniela, Parruti, Giustino, Polilli, Ennio, Sacchini, Daria, Martinelli, Chiara, Consolini, Rita, Vatteroni, Linda, Vivarelli, Angela, Nerli, Alessandro, Lenzi, Lucia, Magnani, Giacomo, Ortolani, Patrizia, Andreoni, Massimo, Fimiani, Caterina, Palmisano, Lucia, Di Giambenedetto, Simona, Vullo, Vincenzo, Turriziani, Ombretta, Montano, Marco, Antinori, Andrea, Zaccarelli, Mauro, Dentone, Chiara, Gonnelli, Angela, De Luca, Andrea, Palumbo, Michele, Ghisetti, Valeria, Bonora, Stefano, Delle Foglie, Palma, Rossi, Cristina, Mondino, Vincenzo, Malena, Marina, Grossi, Paolo, Seminari, Elena, Poletti, Federica, Ungaro, R., Taramasso, L., Bruzzone, B., Vicenti, I., Galli, L., Borghi, V., Francisci, D., Pecorari, M., Zoncada, A., Callegaro, A.P., Paolini, E., Monno, L., Bonora, S., and Di Biagio, A.

Published
2019
Full Text
View/download PDF

3. Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Author

Prosperi, Mattia C. F., Mackie, Nicola, Di Giambenedetto, Simona, Zazzi, Maurizio, Camacho, Ricardo, Fanti, Iuri, Torti, Carlo, Sönnerborg, Anders, Kaiser, Rolf, Codoñer, Francisco M., Van Laethem, Kristel, Bansi, Loveleen, van de Vijver, David A. M. C., Geretti, Anna Maria, De Luca, Andrea, Giacometti, Andrea, Butini, Luca, del Gobbo, Romana, Menzo, Stefano, Tacconi, Danilo, Corbelli, Giovanni, Zanussi, Stefania, Monno, Laura, Punzi, Grazia, Maggiolo, Franco, Callegaro, Annapaola, Calza, Leonardo, Carla Re, Maria, Pristerà, Raffaele, Turconi, Paola, Mandas, Antonella, Tini, Sauro, Zoncada, Alessia, Paolini, Elisabetta, Amadio, Giorgio, Sighinolfi, Laura, Zuccati, Giuliano, Morfini, Massimo, Manetti, Roberto, Corsi, Paola, Galli, Luisa, Di Pietro, Massimo, Bartalesi, Filippo, Colao, Grazia, Tosti, Andrea, Di Biagio, Antonio, Setti, Maurizio, Bruzzone, Bianca, Penco, Giovanni, Trezzi, Michele, Orani, Anna, Pardelli, Riccardo, De Gennaro, Michele, Chiodera, Alessandro, Scalzini, Alfredo, Palvarini, Loredana, Almi, Paolo, Todaro, Giovanni, dʼArminio Monforte, Antonella, Cicconi, Paola, Rusconi, Stefano, Gismondo, Maria Rita, Gismondo, Maria Rita, Micheli, Valeria, Biondi, Maria Luisa, Gianotti, Nicola, Capetti, Amedeo, Meraviglia, Paola, Boeri, Enzo, Mussini, Cristina, Pecorari, Monica, Soria, Alessandro, Vecchi, Laura, Santirocchi, Maurizio, Brustia, Diego, Ravanini, Paolo, Bello, Federico Dal, Romano, Nino, Mancuso, Salvatrice, Calzetti, Carlo, Maserati, Renato, Filice, Gaetano, Baldanti, Fausto, Francisci, Daniela, Parruti, Giustino, Polilli, Ennio, Sacchini, Daria, Martinelli, Chiara, Consolini, Rita, Vatteroni, Linda, Vivarelli, Angela, Dionisio, Daniele, Nerli, Alessandro, Lenzi, Lucia, Magnani, Giacomo, Ortolani, Patrizia, Andreoni, Massimo, Palamara, Guido, Fimiani, Caterina, Palmisano, Lucia, De Luca, Andrea, Fadda, Giovanni, Vullo, Vincenzo, Turriziani, Ombretta, Montano, Marco, Cenderello, Giovanni, Gonnelli, Angela, Zazzi, Maurizio, Palumbo, Michele, Ghisetti, Valeria, Bonora, Stefano, Foglie, Palma Delle, Rossi, Cristina, Grossi, Paolo, Seminari, Elena, Poletti, Federica, Mondino, Vincenzo, Malena, Marina, Lattuada, Emanuela, Lengauer, Thomas, Däumer, Martin, Hoffmann, Daniel, Kaiser, Rolf, Schülter, Eugen, Müller, Claudia, Oette, Mark, Reuter, Stefan, Esser, Stefan, Fätkenheuer, Gerd, Rockstroh, Jürgen, van de Vijver, David AMC, Incardona, Francesca, Rosen-Zvi, Michal, Lengauer, Thomas, Camacho, Ricardo, Clotet, Bonaventura, Thalme, Anders, Svedhem, Veronica, Bratt, Göran, Gargiulo, Franco, Lapadula, Giuseppe, Manca, Nino, Paraninfo, Giuseppe, Quiros-Roldan, Eugenia, Carosi, Giampiero, Castelnuovo, Filippo, Vandamme, Anne-Mieke, Van Laethem, Kristel, Van Wijngaerden, Eric, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Dunn, David, Easterbrook, Philippa, Fisher, Martin, Gazzard, Brian, Garrett, Nigel, Gilson, Richard, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Leen, Clifford, Orkin, Chloe, Phillips, Andrew, Pillay, Deenan, Porter, Kholoud, Post, Frank, Sabin, Caroline, Sadiq, Tariq, Schwenk, Achim, Walsh, John, Delpech, Valerie, Palfreeman, Adrian, Dunn, David, Glabay, Adam, Porter, Kholoud, Bansi, Loveleen, Hill, Teresa, Phillips, Andrew, Sabin, Caroline, Orkin, Chloe, Garrett, Nigel, Lynch, Janet, Hand, James, de Souza, Carl, Fisher, Martin, Perry, Nicky, Tilbury, Stuart, Churchill, Duncan, Gazzard, Brian, Nelson, Mark, Waxman, Matthew, Mandalia, Sundhiya, Delpech, Valerie, Anderson, Jane, Kall, Meaghan, Post, Frank, Korat, Hardik, Taylor, Chris, Ibrahim, Fowzia, Campbell, Lucy, Easterbrook, Philippa, Babiker, Abdel, Dunn, David, Glabay, Adam, Porter, Kholoud, Gilson, Richard, James, Laura, Brima, Nataliya, Williams, Ian, Schwenk, Achim, Johnson, Margaret, Youle, Mike, Lampe, Fiona, Smith, Colette, Grabowska, Helen, Chaloner, Clinton, Puradiredja, Dewi Ismajani, Bansi, Loveleen, Hill, Teresa, Phillips, Andrew, Sabin, Caroline, Walsh, John, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Leen, Clifford, Wilson, Alan, Gompels, Mark, Dooley, Debbie, Palfreeman, Adrian, Anderson, Jane, Asboe, David, Pozniak, Anton, Cameron, Sheila, Cane, Patricia, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Delpech, Valerie, Pillay, Deenan, Lazarus, Linda, Dunn, David, Dolling, David, Fearnhill, Esther, Castro, Hannah, Porter, Kholoud, Coughlin, Kate, Dolling, David, Zuckerman, Mark, Anna Maria, Geretti, Booth, Clare, Goldberg, David, Gompels, Mark, Hale, Antony, Kaye, Steve, Kellam, Paul, Leigh-Brown, Andrew, Mackie, Nicola, Orkin, Chloe, Pillay, Deenan, Phillips, Andrew, Sabin, Caroline, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Tong, William, Williams, Ian, Zhang, Hongyi, Zhang, Hongyi, Clark, Duncan, Ushiro-Lumb, Ines, Oliver, Tony, Bibby, David, Mitchell, Suzanne, Smit, Erasmus, Mbisa, Tamyo, Wildfire, Adrian, Tandy, Richard, Shepherd, Jill, Chadwick, David, MacLean, Alasdair, Tong, William, Bennett, Diane, Hopkins, Mark, Tilston, Peter, Booth, Clare, Garcia-Diaz, Ana, Kaye, Steve, and Kirk, Stuart

Published
2011
Full Text
View/download PDF

5. Prevalence of acquired resistance mutations in a large cohort of perinatally infected HIV-1 patients

Author

Ungaro, R., primary, Taramasso, L., additional, Bruzzone, B., additional, Vicenti, I., additional, Galli, L., additional, Borghi, V., additional, Francisci, D., additional, Pecorari, M., additional, Zoncada, A., additional, Callegaro, A.P., additional, Paolini, E., additional, Monno, L., additional, Bonora, S., additional, Di Biagio, A., additional, Giacometti, Andrea, additional, Butini, Luca, additional, del Gobbo, Romana, additional, Bagnarelli, Patrizia, additional, Tacconi, Danilo, additional, Corbelli, Giovanni, additional, Zanussi, Stefania, additional, Monno, Laura, additional, Punzi, Grazia, additional, Maggiolo, Franco, additional, Calza, Leonardo, additional, Carla Re, Maria, additional, Pristera, Raffaele, additional, Turconi, Paola, additional, Mandas, Antonella, additional, Tini, Sauro, additional, Zoncada, Alessia, additional, Paolini, Elisabetta, additional, Amadio, Giorgio, additional, Sighinolfi, Laura, additional, Corsi, Paola, additional, Galli, Luisa, additional, Di Pietro, Massimo, additional, Colao, Grazia, additional, Tosti, Andrea, additional, Setti, Maurizio, additional, Bruzzone, Bianca, additional, Di Biagio, Antonio, additional, Cenderello, Giovanni, additional, Trezzi, Michele, additional, Orani, Anna, additional, Arcidiacono, Irene, additional, Degiuli, Alberto, additional, De Gennaro, Michele, additional, Chiodera, Alessandro, additional, Scalzini, Alfredo, additional, Palvarini, Loredana, additional, Todaro, Giovanni, additional, Rusconi, Stefano, additional, Gismondo, Maria Rita, additional, Micheli, Valeria, additional, Biondi, Maria Luisa, additional, Capetti, Amedeo, additional, Meraviglia, Paola, additional, Boeri, Enzo, additional, Mussini, Cristina, additional, Pecorari, Monica, additional, Soria, Alessandro, additional, Vecchi, Laura, additional, Santirocchi, Maurizio, additional, Brustia, Diego, additional, Ravanini, Paolo, additional, Dal Bello, Federico, additional, Romano, Nino, additional, Mancuso, Salvatrice, additional, Calzetti, Carlo, additional, Maserati, Renato, additional, Filice, Gaetano, additional, Baldanti, Fausto, additional, Francisci, Daniela, additional, Parruti, Giustino, additional, Polilli, Ennio, additional, Sacchini, Daria, additional, Martinelli, Chiara, additional, Consolini, Rita, additional, Vatteroni, Linda, additional, Vivarelli, Angela, additional, Nerli, Alessandro, additional, Lenzi, Lucia, additional, Magnani, Giacomo, additional, Ortolani, Patrizia, additional, Andreoni, Massimo, additional, Fimiani, Caterina, additional, Palmisano, Lucia, additional, Di Giambenedetto, Simona, additional, Vullo, Vincenzo, additional, Turriziani, Ombretta, additional, Montano, Marco, additional, Antinori, Andrea, additional, Zaccarelli, Mauro, additional, Dentone, Chiara, additional, Gonnelli, Angela, additional, De Luca, Andrea, additional, Palumbo, Michele, additional, Ghisetti, Valeria, additional, Bonora, Stefano, additional, Delle Foglie, Palma, additional, Rossi, Cristina, additional, Mondino, Vincenzo, additional, Malena, Marina, additional, Grossi, Paolo, additional, Seminari, Elena, additional, and Poletti, Federica, additional

Published
2019
Full Text
View/download PDF

8. The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

Author

Di Biagio, Antonio, Rusconi, Stefano, Marzocchetti, Angela, Signori, Alessio, Schiavetti, Irene, Bruzzone, Bianca, Monno, Laura, Punzi, Grazia, Colao, Maria Grazia, Penco, Giovanni, Zazzi, Maurizio, De Luca, Andrea, Giacometti, Andrea, Butini, Luca, Del Gobbo, Romana, Bagnarelli, Patrizia, Tacconi, Danilo, Corbelli, Giovanni, Zanussi, Stefania, Maggiolo, Franco, Callegaro, Annapaola, Calza, Leonardo, Maria Carla, Re, Pristerà, Raffaele, Turconi, Paola, Mandas, Antonella, Pozzo, Alessandra, Simeone, Nuccia, Tini, Sauro, Zoncada, Alessia, Paolini, Elisabetta, Amadio, Giorgio, Sighinolfi, Laura, Zuccati, Giuliano, Morfini, Massimo, Manetti, Roberto, Corsi, Paola, Galli, Luisa, Di Pietro, Massimo, Bartalesi, Filippo, Colao, Grazia, Tosti, Andrea, Setti, Maurizio, Trezzi, Michele, Bonfanti, Paolo, Pardelli, Riccardo, Arcidiacono, Irene, Degiuli, Alberto, De Gennaro, Michele, Chiodera, Alessandro, Scalzini, Alfredo, Palvarini, Loredana, Almi, Paolo, Todaro, Giovanni, Cicconi, Paola, Gismondo, Maria Rita, Micheli, Valeria, Biondi, Maria Luisa, Gianotti, Nicola, Capetti, Amedeo, Meraviglia, Paola, Boeri, Enzo, Mussini, Cristina, Pecorari, Monica, Soria, Alessandro, Malandrin, Sergio, Santirocchi, Maurizio, Brustia, Diego, Ravanini, Paolo, Dal Bello, Federico, Romano, Nino, Mineo, Maurizio, Mancuso, Salvatrice, Calzetti, Carlo, Maserati, Renato, Filice, Gaetano, Baldanti, Fausto, Francisci, Daniela, Parruti, Giustino, Polilli, Ennio, Sacchini, Daria, Martinelli, Chiara, Consolini, Rita, Vatteroni, Linda, Vivarelli, Angela, Nerli, Alessandro, Lenzi, Lucia, Magnani, Giacomo, Ortolani, Patrizia, Andreoni, Massimo, Palamara, Guido, Fimiani, Caterina, Palmisano, Lucia, Di Gaimbenedetto, Simona, Colafigli, Manuela, Vullo, Vincenzo, Turriziani, Ombretta, Montano, Marco, Senatore, Cataldo, Dentone, Chiara, Gonnelli, Angela, Palumbo, Michele, Ghisetti, Valeria, Bonora, Stefano, Foglie, Palma Delle, Rossi, Cristina, Grossi, Paolo, Seminari, Elena, Poletti, Federica, Mondino, Vincenzo, and Malena, Marina

Subjects
Adult, Male, Adolescent, Genotype, Antiretroviral Therapy, HIV Infections, Settore MED/17 - MALATTIE INFETTIVE, wGSS, Young Adult, Virology, Antiretroviral Therapy, Highly Active, Drug Resistance, Viral, 80 and over, Humans, Highly Active, HIV-1 RNA, Viral, Longitudinal Studies, CD4, Drug regimen, Drug resistance, N(n)RTI backbone, WGSS, Infectious Diseases, Aged, Aged, 80 and over, Anti-Retroviral Agents, CD4 Lymphocyte Count, Female, HIV-1, Italy, Middle Aged, RNA, Viral, Retrospective Studies, Treatment Outcome, Viral Load, drug regimen, drug resistance, RNA
Abstract

The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load50 copies/ml. Time to events were analyzed by Kaplan-Meier analysis and Cox proportional hazard model. One thousand three hundred five patients met the study inclusion criteria. In a multivariable model adjusting for transmission mode, presence of transmitted drug resistance, baseline CD4(+) cell count, viral subtype, and type of NRTI backbone employed, independent predictors of virological success were higher baseline viral load (≥500,000 vs.100,000 HR 0.52; P 0.001), a weighted genotypic susceptibility score (wGSS)3 (HR 0.58; P = 0.003), male sex (HR 0.76 P = 0.001), and type of initial third drug employed (integrase inhibitor vs. boosted protease inhibitors HR 3.23; P 0.001). In the subset with HIV-1 RNA100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4(+) cell count and wGSS3. High baseline HIV-1 RNA, predicted activity of the first-line regimen based on genotypic resistance testing, gender, and use of new agents were found to predict time to achieve virological success. The type of initial nucleoside analog backbone was not found to predict virological response.

Published
2014

9. Renal toxicity in HIV-infected patients receiving HAART includine tenofovir [Tossicità renale in pazienti con infezione da HIV in trattamento con HAART contenente tenofovir]

Author

Madeddu, G, Quirino, T, Carradori, S, Ricci, E, Grosso, C, Penco, G, De Socio, G, Rossella, E, Palvarini, L, Marconi, P, Melzi, S, Mura, M, Bonfanti, P, Madeddu, Giordano, Quirino, Tiziana, Carradori, Silvia, Ricci, Elena, Grosso, Carmela, Penco, Giovanni, De Socio, Giuseppe, Rossella, Elena, Palvarini, Loredana, Marconi, Patrizia, Melzi, Sara, Mura, Maria Stella, Bonfanti, Paolo, Madeddu, G, Quirino, T, Carradori, S, Ricci, E, Grosso, C, Penco, G, De Socio, G, Rossella, E, Palvarini, L, Marconi, P, Melzi, S, Mura, M, Bonfanti, P, Madeddu, Giordano, Quirino, Tiziana, Carradori, Silvia, Ricci, Elena, Grosso, Carmela, Penco, Giovanni, De Socio, Giuseppe, Rossella, Elena, Palvarini, Loredana, Marconi, Patrizia, Melzi, Sara, Mura, Maria Stella, and Bonfanti, Paolo

Abstract

HIV-infected patients may undergo renal damage related to the HIV infection itself, to the presence of co-infections, arterial hypertension, diabetes or to the exposure to nephrotoxic drugs. Tenofovir has been associated with the development of acute renal failure with Fanconi syndrome and acute tubular necrosis and, albeit rarely, with chronic liver disease. Patients with low CD4 cell count, low body weight and with concomitant diseases such as arterial hypertension and diabetes or co-infections with HCV, HBV or Treponema pallidum seem at higher risk of tenofovir-related nephrotoxicity. Other risk factors include previous exposure to nephrotoxic drugs and the association of tenofovir with boosted protease inhibitors or with didanosine. However, from the analysis of published papers the incidence of tenofovir-related renal toxicity seems low, as confirmed also by our personal casuistry (SCOLTA Project). Thus, a careful selection of patients including the evaluation of existent renal disease before starting an antiretroviral regimen including tenofovir is necessary to prevent renal damage. Furthermore, frequent monitoring of renal function in patients at higher risk of renal damage is strongly recommended, as well as a tenofovir dose adjustment if an alteration of renal function is detected.

Published
2006

14. Naive CD4+ T Lymphocytes Express High Levels of Bcl-2 after Highly Active Antiretroviral Therapy for HIV Infection

Author

Airò, Paolo, Torti, Carlo, Uccelli, Maria Cristina, Malacarne, Fabio, Palvarini, Loredana, Carosi, Giampiero, and Castelli, Francesco

Abstract

The mechanism causing the increasing number of peripheral T cells after highly active antiretroviral therapy (HAART) is still unclear. The bcl-2 oncogene prevents spontaneous apoptosis (SA) in lymphocytes. Spontaneous apoptosis could be a determinant of HIV immunodeficiency and can be reversed by HAART including protease inhibitors (PI-HAART). The aims of our study were to measure Bcl-2 protein expression in memory (CD45RO+) and naive (CD45RO-) CD4+ and CD8+ T lymphocytes of HIV+ patients and to correlate it with efficacy of PIHAART. Forty-nine HIV+ patients (cases) and 26 HIV- individuals (controls) were evaluated. Patients receiving PI-HAART, and who had undetectable HIV plasma viral load (VL-, n = 21), had higher levels of Bcl-2 than did VL+ patients (n = 28), both in CD4+ cells (p < 0.0001) and in CD8+ cells (p < 0.001). VL+ patients had lower Bcl-2 levels than did controls in CD8+ cells (p = 0.02), but not in CD4+ cells (p > 0.05). Interestingly, VL- patients had higher Bcl-2 expression than did controls both in CD4+ cells (p < 0.0001) and in CD8+ cells (p = 0.03). In a subcohort of the same patients, Bcl-2 was significantly higher in VL- patients (n = 10) than in controls (n = 12), both in naive CD4+ cells (p < 0.0001) and in naive CD8+ cells (p = 0.01). Naive CD4+ cells had higher Bcl-2 expression in VL- than in VL+ patients (p = 0.01). In a subsequent longitudinal study of nine HIV patients, naive CD4+ cells increased after effective PI-HAART (p = 0.03), which paralleled an increase in Bcl-2 expression in the same cells (p = 0.02). In conclusion, upregulation of bcl-2 could be a mechanism of immune reconstitution of naive CD4+ T cells induced by PI-HAART.

Published
2000
Full Text
View/download PDF

15. Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).

Author

Gianotti N, Galli L, Maserati R, Sighinolfi L, Ripamonti D, Palvarini L, Lo Caputo S, Focà E, Celesia BM, Baldelli F, Sterrantino G, and Lazzarin A

Subjects
Adult, Anti-HIV Agents therapeutic use, Antiretroviral Therapy, Highly Active, Darunavir administration & dosage, Female, Humans, Lopinavir administration & dosage, Male, Middle Aged, Ritonavir administration & dosage, Darunavir therapeutic use, HIV Infections drug therapy, Lopinavir therapeutic use, Ritonavir therapeutic use
Abstract

In a multicentre, open-label, clinical trial, 43 patients virologically suppressed while receiving a standard triple antiretroviral therapy were randomized (1:1:1) to switch to monotherapy with darunavir/ritonavir (DRV/r-MT arm), monotherapy with lopinavir/ritonavir (LPV/r-MT arm) or to continue on the ongoing regimen (cART arm). The proportion (95% CI) of patients with virological success (Snapshot analysis) at week 48 was 73% (48%-90%) in the DRV/r-MT arm, 69% (42%-88%) in the LPV/r-MT arm and 87% (61%-98%) in the cART arm. Virological failure was detected in only one patient receiving LPV/r-MT. The LPV/r-MT arm showed a modest worsening in lipid profile.

Published
2016

16. [Epidemiology of ESBL-positive Enterobacteriaceae in Mantova hospital (Italy)].

Author

Gattuso G, Tomasoni D, Palvarini L, Chiarelli C, Nespeca M, Stradoni R, Ceruti R, Ferri F, and Scalzini A

Subjects
Adult, Cross Infection microbiology, Enterobacteriaceae enzymology, Enterobacteriaceae Infections microbiology, Escherichia coli enzymology, Escherichia coli isolation & purification, Escherichia coli Infections epidemiology, Escherichia coli Infections microbiology, Hospital Departments statistics & numerical data, Humans, Immunologic Surveillance, Infant, Newborn, Intensive Care Units, Neonatal statistics & numerical data, Italy epidemiology, Klebsiella enzymology, Klebsiella isolation & purification, Klebsiella Infections epidemiology, Klebsiella Infections microbiology, Proteus enzymology, Proteus isolation & purification, Proteus Infections epidemiology, Proteus Infections microbiology, Substrate Specificity, Bacterial Proteins analysis, Cross Infection epidemiology, Enterobacteriaceae isolation & purification, Enterobacteriaceae Infections epidemiology, Hospitals, Urban statistics & numerical data, beta-Lactam Resistance, beta-Lactamases analysis
Abstract

In a retrospective study concerning the epidemiology of extended-spectrum beta-lactamase (ESBL) positive Enterobacteriaceae during 2007-2008 in the wards of the Carlo Poma hospital in Mantova, Mercurio surveillance software was used to detect alert microorganisms. Our objective was to link the epidemiological data with the type of patient and ward, and to assess the risk factors for such infections in particular nosocomial environments. The study enabled the change in the relative epidemiological data to be detected, and showed that such bacteria can be found almost throughout the hospital.

Published
2009

17. [Reduced incidence of Staphylococcus isolation in nosocomial setting after introducing preoperative antibiotic prophylaxis guidelines].

Author

Gattuso G, Berra D, Palvarini L, Tomasoni D, Chiarelli C, Stradoni R, and Scalzini A

Subjects
Cephalosporins administration & dosage, Cephalosporins classification, Cross Infection prevention & control, Drug Utilization statistics & numerical data, Humans, Incidence, Italy epidemiology, Methicillin Resistance, Postoperative Complications prevention & control, Practice Guidelines as Topic, Retrospective Studies, Staphylococcal Infections prevention & control, Staphylococcus aureus drug effects, Staphylococcus aureus isolation & purification, Surgery Department, Hospital statistics & numerical data, Antibiotic Prophylaxis statistics & numerical data, Cephalosporins therapeutic use, Cross Infection epidemiology, Guideline Adherence statistics & numerical data, Postoperative Complications epidemiology, Preanesthetic Medication statistics & numerical data, Staphylococcal Infections epidemiology
Abstract

We compare epidemiological data from two twelve-month periods, before and after the introduction of preoperative antibiotic prophylaxis guidelines at Carlo Poma hospital in Mantova, Italy, in June 2003. Considering the results from the microbiology laboratory and the data from the pharmacy, concerning the consumption of some antimicrobials, we noted a significant decrease in the incidence of methicillin-resistant Staphylococcus aureus (MRSA) in surgical wards, where the incidence of MRSA had previously exceeded that in medical wards. At the same time, analysis of antibiotic consumption revealed a considerable decrease in third and fourth-generation cephalosporins and an increasing use of cephazolin, in compliance with prophylaxis protocol rules. This trend was confirmed by analysis of the same data regarding the first six months of 2006.

Published
2007

18. [Renal toxicity in HIV-infected patients receiving HAART including tenofovir].

Author

Madeddu G, Quirino T, Carradori S, Ricci E, Grosso C, Penco G, De Socio G, Rossella E, Palvarini L, Marconi P, Melzi S, Mura MS, and Bonfanti P

Subjects
Adenine adverse effects, Drug Interactions, Humans, Tenofovir, Adenine analogs & derivatives, Anti-HIV Agents adverse effects, Antiretroviral Therapy, Highly Active adverse effects, HIV Infections drug therapy, Kidney Diseases chemically induced, Organophosphonates adverse effects
Abstract

HIV-infected patients may undergo renal damage related to the HIV infection itself, to the presence of co-infections, arterial hypertension, diabetes or to the exposure to nephrotoxic drugs. Tenofovir has been associated with the development of acute renal failure with Fanconi syndrome and acute tubular necrosis and, albeit rarely, with chronic liver disease. Patients with low CD4 cell count, low body weight and with concomitant diseases such as arterial hypertension and diabetes or co-infections with HCV, HBV or Treponema pallidum seem at higher risk of tenofovir-related nephrotoxicity. Other risk factors include previous exposure to nephrotoxic drugs and the association of tenofovir with boosted protease inhibitors or with didanosine. However, from the analysis of published papers the incidence of tenofovir-related renal toxicity seems low, as confirmed also by our personal casuistry (SCOLTA Project). Thus, a careful selection of patients including the evaluation of existent renal disease before starting an antiretroviral regimen including tenofovir is necessary to prevent renal damage. Furthermore, frequent monitoring of renal function in patients at higher risk of renal damage is strongly recommended, as well as a tenofovir dose adjustment if an alteration of renal function is detected.

Published
2006

19. Effect of HAART on SEN virus infected HIV positive patients.

Author

Pirovano S, Malacarne F, Ballerini C, Stellini R, Palvarini L, Albertini A, and Imberti L

Subjects
Circoviridae genetics, Circoviridae isolation & purification, Circoviridae Infections virology, DNA, Viral blood, Female, HIV Infections complications, Humans, Male, Middle Aged, Antiretroviral Therapy, Highly Active, Circoviridae Infections complications, HIV Infections drug therapy
Abstract

Since it has been demonstrated that concomitant infections could influence the outcome of antiviral treatment, we investigated whether the presence of SENV infection may interfere with highly active antiretroviral therapy (HAART) in HIV+ coinfected patients. In spite of persistent fluctuations in SENV-A positivity we could not find any correlation between SENV-DNA and the immunological and virologic parameters found in the patients, suggesting SENV has no apparent clinical relevance during highly active antiretroviral therapy.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results