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Background: Digital tools and interventions are being increasingly developed in response to the growing mental health crisis, and mental health professionals (MHPs) considerably influence their adoption in client practice. However, how MHPs use digital tools in client interaction is yet to be sufficiently understood, which poses challenges to their design, development, and implementation. Objective: This study aimed to create a contextual understanding of how MHPs use different digital tools in clinical client practice and what characterizes the use across tools. Methods: A total of 19 Finnish MHPs participated in semistructured interviews, and the data were transcribed, coded, and inductively analyzed. Results: We found that MHP digital tool use was characterized by 3 distinct functions: communication, diagnosis and evaluation, and facilitating therapeutic change. The functions were addressed using analog tools, digitized tools that mimic their analog counterparts, and digital tools that use the possibilities native to digital. The MHP-client communication included various media alongside face-to-face meetings, the MHPs increasingly used digitized tools in client evaluation, and the MHPs actively used digitized materials to facilitate therapeutic change. MHP tool use was generally characterized by adaptability—it was negotiated in client interactions. However, there was considerable variance in the breadth of MHPs’ digital toolbox. The existing clinical practices emphasized MHP-client interaction and invited incremental rather than radical developments, which challenged the achievement of the scalability benefits expected from digital tools. Conclusions: MHPs use digitized and digital tools in client practice. Our results contribute to the user-centered research, development, and implementation of new digital solutions in mental health care by classifying them according to their function and medium and describing how MHPs use and do not use them. peerReviewed

Inter-areal synchronization by phase-phase correlations (PPCs) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography to examine brain-wide cortical PPC networks at term-equivalent age, comparing human infants after early prematurity to a cohort of healthy controls. We found that prematurity affected these networks in a sleep state-specific manner, and the differences between groups were also frequency-selective, involving brain-wide connections. The strength of synchronization in these networks was predictive of clinical outcomes in the preterm infants. These findings show that prematurity affects PPC networks in a clinically significant manner, suggesting early functional biomarkers of later neurodevelopmental compromise that may be used in clinical or translational studies after early neonatal adversity.

Funding Information: We would like to thank Frances Crabbe, MSc, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, Scotland for help in the acquisition of MEG/MRI-data. The investigators also acknowledge the support of the Scottish Mental Health Research Network (http://www.smhrn.org.uk), now called the NHS Research Scotland Mental Health Network (http://www.nhsresearchscotland.org.uk/research-areas/mental-health), for providing assistance with participant recruitment, interviews, and cognitive assessments. We thank both the participants and patients who took part in the study and the research assistants of the YouR-study for supporting the recruitment and assessment of CHR participants. The study was supported by the Medical Research Council (MR/L011689/1) and ERANET-Project ?IMBALANCE?. Funding Information: The study was supported by the Medical Research Council (MR/L011689/1) and ERANET-Project “IMBALANCE”. Publisher Copyright: © 2021 The Authors Long-Range Temporal Correlations (LRTCs) index the capacity of the brain to optimally process information. Previous research has shown that patients with chronic schizophrenia present altered LRTCs at alpha and beta oscillations. However, it is currently unclear at which stage of schizophrenia aberrant LRTCs emerge. To address this question, we investigated LRTCs in resting-state magnetoencephalographic (MEG) recordings obtained from patients with affective disorders and substance abuse (clinically at low-risk of psychosis, CHR-N), patients at clinical high-risk of psychosis (CHR-P) (n = 115), as well as patients with a first episode (FEP) (n = 25). Matched healthy controls (n = 47) served as comparison group. LRTCs were obtained for frequencies from 4 to 40 Hz and correlated with clinical and neuropsychological data. In addition, we examined the relationship between LRTCs and transition to psychosis in CHR-P participants, and the relationship between LRTC and antipsychotic medication in FEP participants. Ourresults show that participants from the clinical groups have similar LRTCs to controls. In addition, LRTCs did not correlate with clinical and neurocognitive variables across participants nor did LRTCs predict transition to psychosis. Therefore, impaired LRTCs do not reflect a feature in the clinical trajectory of psychosis. Nevertheless, reduced LRTCs in the beta-band over posterior sensors of medicated FEP participants indicate that altered LRTCs may appear at the onset of the illness. Future studies are needed to elucidate the role of anti-psychotic medication in altered LRTCs.

BACKGROUND:\ud Reproducibility of research findings has been recently questioned in many fields of science, including psychology and neurosciences. One factor influencing reproducibility is the simultaneous testing of multiple hypotheses, which entails false positive findings unless the analyzed p-values are carefully corrected. While this multiple testing problem is well known and studied, it continues to be both a theoretical and practical problem.\ud \ud NEW METHOD:\ud Here we assess reproducibility in simulated experiments in the context of multiple testing. We consider methods that control either the family-wise error rate (FWER) or false discovery rate (FDR), including techniques based on random field theory (RFT), cluster-mass based permutation testing, and adaptive FDR. Several classical methods are also considered. The performance of these methods is investigated under two different models.\ud \ud RESULTS:\ud We found that permutation testing is the most powerful method among the considered approaches to multiple testing, and that grouping hypotheses based on prior knowledge can improve power. We also found that emphasizing primary and follow-up studies equally produced most reproducible outcomes.\ud \ud COMPARISON WITH EXISTING METHOD(S):\ud We have extended the use of two-group and separate-classes models for analyzing reproducibility and provide a new open-source software "MultiPy" for multiple hypothesis testing.\ud \ud CONCLUSIONS:\ud Our simulations suggest that performing strict corrections for multiple testing is not sufficient to improve reproducibility of neuroimaging experiments. The methods are freely available as a Python toolkit "MultiPy" and we aim this study to help in improving statistical data analysis practices and to assist in conducting power and reproducibility analyses for new experiments.