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5. Machine Learning Algorithm Prospectively Predicts Survival for High-Risk Patients Undergoing Radiotherapy: A Survival Analysis of SHIELD-RT

Author

Natesan, D., primary, Thomas, S.M., additional, Eclov, N., additional, Dalal, N.H., additional, Stephens, S.J., additional, Malicki, M., additional, Shields, S., additional, Cobb, A., additional, Mowery, Y.M., additional, Niedzwiecki, D., additional, Tenenbaum, J.D., additional, Palta, M., additional, and Hong, J.C., additional

Published
2021
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10. Place-making, place-disruption, and place protection of urban blue spaces: perceptions of waterfront planning of a polluted urban waterbody

Author

Toomey, A.H., Campbell, L.K., Johnson, M., Strehlau-Howay, L., Manzolillo, B., Thomas, C., Graham, T., and Palta, M.

Abstract

Urban waterfronts are experiencing a renaissance, as it is estimated that by 2030 more than 60 percent of the world's population will live in cities, the majority of which are located in coastal or riparian regions. On a global level, changing public demands have spurred a new language of sustainability, revitalisation, and resilience with regard to urban waterfronts. Prior research has explored the potential ecological and social impacts of these trends, both in terms of benefits such as opportunities for recreation, as well as negative consequences such as increasing gentrification. Less explored, however, are how these planning and development processes can alternately support and/or interrupt existing “sense of place” that people hold with waterfront spaces, particularly spaces considered to be degraded and/or that are located in marginalised communities. This paper explores place-making, place-disruption and place protection associated with Coney Island Creek, a heavily polluted waterbody in New York City. We find that the creek provides recreation, sustenance, and social connections for substantial numbers of people, and we discuss these findings in the context of proposed resiliency planning and development projects that are perceived by some local stewards to threaten existing place attachments and meanings. In particular, we emphasise the importance of incorporating local knowledge and values in waterfront planning, especially in neighbourhoods that have been historically marginalised. This study contributes to a growing literature on values associated with urban blue spaces, thus furthering knowledge of how to improve current environmental governance strategies in coastal cities around the world.

Published
2021
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15. Randomized, Double-Blinded, Placebo-controlled Multicenter Adaptive Phase 1-2 Trial of GC 4419, a Dismutase Mimetic, in Combination with High Dose Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (PC)

Author

Hoffe, S., primary, Frakes, J.M., additional, Aguilera, T.A., additional, Czito, B., additional, Palta, M., additional, Brookes, M., additional, Schweizer, C., additional, Colbert, L., additional, Moningi, S., additional, Bhutani, M.S., additional, Pant, S., additional, Tzeng, C.W., additional, Tidwell, R.S., additional, Thall, P., additional, Yuan, Y., additional, Moser, E.C., additional, Holmlund, J., additional, Herman, J., additional, and Taniguchi, C.M., additional

Published
2020
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26. A current perspective on stereotactic body radiation therapy for pancreatic cancer

Author

Hong JC, Czito BG, Willett CG, and Palta M

Subjects
stereotactic body radiotherapy (SBRT), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, radiation therapy, lcsh:RC254-282, Pancreas cancer
Abstract

Julian C Hong, Brian G Czito, Christopher G Willett, Manisha Palta Department of Radiation Oncology, Duke University, Durham, NC, USA Abstract: Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or chemoradiation is associated with high rates of local tumor progression and metastases development, resulting in low survival rates. An emerging local modality is stereotactic body radiation therapy (SBRT), which uses image-guided, conformal, high-dose radiation. SBRT has demonstrated promising local control rates and resultant quality of life with acceptable rates of toxicity. Over the past decade, increasing clinical experience and data have supported SBRT as a local treatment modality. Nevertheless, additional research is required to further evaluate the role of SBRT and improve upon the persistently poor outcomes associated with pancreatic cancer. This review discusses the existing clinical experience and technical implementation of SBRT for pancreatic cancer and highlights the directions for ongoing and future studies. Keywords: pancreatic cancer, stereotactic body radiation therapy, SBRT, radiation therapy

Published
2016

30. Imaging & Biomarker Correlates on Outcomes in a Phase II Trial of Neoadjuvant Gemcitabine/Nab-Paclitaxel and Hypofractionated Image-Guided Radiotherapy (HIGRT) in Potentially Resectable Pancreas Cancer

Author

Kent, C.L., primary, Marin, D., additional, Niedzwiecki, D., additional, Stephens, S.J., additional, Duffy, E., additional, Malicki, M., additional, Abbruzzese, J., additional, Uronis, H., additional, Blobe, G., additional, Blazer, D.G., additional, Czito, B., additional, Willett, C.G., additional, and Palta, M., additional

Published
2019
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33. Surgical and Pathologic Outcomes in Patients on a Phase II Trial of Neoadjuvant Chemotherapy and Hypofractionated Image-Guided Intensity Modulated Radiation Therapy (HIGRT) in Resectable and Borderline Resectable Pancreatic Cancer

Author

Stephens, S.J., primary, Czito, B., additional, Zhang, X., additional, Duffy, E., additional, Malicki, M., additional, Pitcher, B., additional, Niedzwiecki, D., additional, Abbruzzese, J., additional, Uronis, H., additional, Blobe, G., additional, Blazer, D.G., additional, Willett, C.G., additional, and Palta, M., additional

Published
2018
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38. Pancreatic Adenocarcinoma Gross Tumor Volume Contouring on Computed Tomography as Compared With Magnetic Resonance Imaging: Results of an International Consensus Contouring Conference

Author

Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, Hall, W. A., Heerkens, H. D., Paulson, E S, Meijer, Gert, Kotte, A. N., Knechtges, P, Parikh, P. J., Bassetti, M. F., Lee, P., Aitken, K. L., Palta, M., Myrehaug, S., Koay, E J, Portelance, L., Ben-Josef, E., Erickson, B A, Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, Hall, W. A., Heerkens, H. D., Paulson, E S, Meijer, Gert, Kotte, A. N., Knechtges, P, Parikh, P. J., Bassetti, M. F., Lee, P., Aitken, K. L., Palta, M., Myrehaug, S., Koay, E J, Portelance, L., Ben-Josef, E., and Erickson, B A

Published
2017

41. Pancreatic Adenocarcinoma Gross Tumor Volume Contouring on Computed Tomography as Compared With Magnetic Resonance Imaging: Results of an International Consensus Contouring Conference

Author

Hall, W.A., primary, Heerkens, H.D., additional, Paulson, E.S., additional, Meijer, G.J., additional, Kotte, A.N., additional, Knechtges, P., additional, Parikh, P.J., additional, Bassetti, M.F., additional, Lee, P., additional, Aitken, K.L., additional, Palta, M., additional, Myrehaug, S., additional, Koay, E.J., additional, Portelance, L., additional, Ben-Josef, E., additional, and Erickson, B.A., additional

Published
2017
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46. Comparison of environmental risk factors for esophageal atresia, anorectal malformations, and the combined phenotype in 263 German families

Author

Zwink, N., Choinitzki, V., Baudisch, F., Hoelscher, A., Boemers, T. M., Turial, S., Kurz, R., Heydweiller, A., Keppler, K., Mueller, A., Bagci, S., Pauly, M., Brokmeier, U., Leutner, A., Degenhardt, P., Schmiedeke, E., Maerzheuser, S., Grasshoff-Derr, S., Holland-Cunz, S., Palta, M., Schaefer, M., Ure, B. M., Lacher, M., Noethen, M. M., Schumacher, J., Jenetzky, E., Reutter, H., Zwink, N., Choinitzki, V., Baudisch, F., Hoelscher, A., Boemers, T. M., Turial, S., Kurz, R., Heydweiller, A., Keppler, K., Mueller, A., Bagci, S., Pauly, M., Brokmeier, U., Leutner, A., Degenhardt, P., Schmiedeke, E., Maerzheuser, S., Grasshoff-Derr, S., Holland-Cunz, S., Palta, M., Schaefer, M., Ure, B. M., Lacher, M., Noethen, M. M., Schumacher, J., Jenetzky, E., and Reutter, H.

Abstract

Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) and anorectal malformations (ARM) represent the severe ends of the fore- and hindgut malformation spectra. Previous research suggests that environmental factors are implicated in their etiology. These risk factors might indicate the influence of specific etiological mechanisms on distinct developmental processes (e.g. fore- vs. hindgut malformation). The present study compared environmental factors in patients with isolated EA/TEF, isolated ARM, and the combined phenotype during the periconceptional period and the first trimester of pregnancy in order to investigate the hypothesis that fore- and hindgut malformations involve differing environmental factors. Patients with isolated EA/TEF (n = 98), isolated ARM (n = 123), and the combined phenotype (n = 42) were included. Families were recruited within the context of two German multicenter studies of the genetic and environmental causes of EA/TEF (great consortium) and ARM (CURE-Net). Exposures of interest were ascertained using an epidemiological questionnaire. Chi-square, Fisher's exact, and Mann-Whitney U-tests were used to assess differences between the three phenotypes. Newborns with isolated EA/TEF and the combined phenotype had significantly lower birth weights than newborns with isolated ARM (P = 0.001 and P < 0.0001, respectively). Mothers of isolated EA/TEF consumed more alcohol periconceptional (80%) than mothers of isolated ARM or the combined phenotype (each 67%). Parental smoking (P = 0.003) and artificial reproductive techniques (P = 0.03) were associated with isolated ARM. Unexpectedly, maternal periconceptional multivitamin supplementation was most frequent among patients with the most severe form of disorder, i.e. the combined phenotype (19%). Significant differences in birth weight were apparent between the three phenotype groups. This might be attributable to the limited ability of EA/TEF fetuses to swallow amniotic fluid, thus d

Published
2016

47. Heterozygous FGF8 mutations in patients presenting cryptorchidism and multiple VATER/VACTERL features without limb anomalies

Author

Zeidler C, Woelfle J, Markus Draaken, Ss, Mughal, Große G, Ac, Hilger, Gc, Dworschak, Tm, Boemers, Jenetzky E, Zwink N, Lacher M, Schmidt D, Schmiedeke E, Grasshoff-Derr S, Märzheuser S, Holland-Cunz S, Schäfer M, Bartels E, Keppler K, Palta M, Leonhardt J, Kujath C, Rißmann A, Mm, Nöthen, Reutter H, and Ludwig M

Subjects
Anti-Mullerian Hormone, Heart Defects, Congenital, Male, Heterozygote, Fibroblast Growth Factor 8, Molecular Sequence Data, Limb Deformities, Congenital, Anal Canal, Enzyme-Linked Immunosorbent Assay, Kidney, Polymerase Chain Reaction, Esophagus, Germany, Cryptorchidism, Humans, Inhibins, Testosterone, DNA Primers, Base Sequence, Sequence Analysis, DNA, Luteinizing Hormone, Spine, Trachea, Gene Components, Mutation, Follicle Stimulating Hormone
Abstract

The acronym VATER/VACTERL association describes the combination of at least three of the following cardinal features: vertebral defects, anorectal malformations, cardiac defects, tracheoesophageal fistula with or without esophageal atresia, renal malformations, and limb defects. Although fibroblast growth factor-8 (FGF8) mutations have mainly found in patients with Kallmann syndrome, mice with a hypomorphic Fgf8 allele or complete gene invalidation display, aside from gonadotropin-releasing hormone deficiency, parts or even the entire spectrum of human VATER/VACTERL association.We performed FGF8 gene analysis in 49 patients with VATER/VACTERL association and 27 patients presenting with a VATER/VACTERL-like phenotype (two cardinal features).We identified two heterozygous FGF8 mutations in patients displaying either VATER/VACTERL association (p.Gly29_Arg34dup) or a VATER/VACTERL-like phenotype (p.Pro26Leu) without limb anomalies. Whereas the duplication mutation has not been reported before, p.Pro26Leu was once observed in a Kallmann syndrome patient. Both our patients had additional bilateral cryptorchidism, a key phenotypic feature in males with FGF8 associated Kallmann syndrome. Each mutation was paternally inherited. Besides delayed puberty in both and additional unilateral cryptorchidism in one of the fathers, they were otherwise healthy. Serum hormone levels downstream the gonadotropin-releasing hormone in both patients and their fathers were within normal range.Our results suggest FGF8 mutations to contribute to the formation of the VATER/VACTERL association. Further studies are needed to support this observation.

Published
2014

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