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309 results on '"Palsson, R"'

2. Infants Requiring Maintenance Dialysis: Outcomes of Hemodialysis and Peritoneal Dialysis

Author

Shtiza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., van Hoeck, K., Collart, F., des Grottes, J.M., Pokrajac, D., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J.G., Toots, U., Finne, P., Grönhagen-Riska, C., Couchoud, C., Lasalle, M., Sahpazova, E., Abazi, N., Ristoka Bojkovska, N., von Gersdorff, G., Scholz, C., Tönshoff, B., Krupka, K., Höcker, B., Pape, L., Afentakis, N., Kapogiannis, A., Printza, N., Reusz, G., Berecki, C.S., Szabó, A., Szabó, T., Györke, Z.S., Kis, E., Palsson, R., Edvardsson, V., Gianoglio, B., Maringhini, S., Pecoraro, C., Picca, S., Testa, S., Rudaitis, S., Said-Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Molchanova, E.A., Tomilina, N.A., Bikbov, B.T., Kostic, M., Peco-Antic, A., Spasojevic-Dimitrijeva, B., Milosevski-Lomic, G., Paripovic, D., Puric, S., Kruscic, D., Podracka, L., Kolvek, G., Buturovic-Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K.G., Backmän, L., Stendahl, M., Evans, M., Rippe, B., Kuenhi, C.E., Maurer, E., Laube, G.F., Tschumi, S., Parvex, P., Hoitsma, A., Hemke, A., Topaloglu, R., Ivanov, D., Pruthi, R., Braddon, F., Mannings, S., Cassula, A., Sinha, M.D., Vidal, Enrico, van Stralen, Karlijn J., Chesnaye, Nicholas C., Bonthuis, Marjolein, Holmberg, Christer, Zurowska, Aleksandra, Trivelli, Antonella, Da Silva, José Eduardo Esteves, Herthelius, Maria, Adams, Brigitte, Bjerre, Anna, Jankauskiene, Augustina, Miteva, Polina, Emirova, Khadizha, Bayazit, Aysun K., Mache, Christoph J., Sánchez-Moreno, Ana, Harambat, Jérôme, Groothoff, Jaap W., Jager, Kitty J., Schaefer, Franz, and Verrina, Enrico

Published
2017
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3. Kidney Versus Combined Kidney and Liver Transplantation in Young People With Autosomal Recessive Polycystic Kidney Disease: Data From the European Society for Pediatric Nephrology/European Renal Association−European Dialysis and Transplant (ESPN/ERA-EDTA) Registry

Author

Levtchenko, E., Haffner, D., Bjerre, A., Massy, Z., Shtiza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., van Hoeck, K., Collart, F., des Grottes, J.M., Pokrajac, D., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J.G., Toots, U., Finne, P., Grönhagen-Riska, C., Couchoud, C., Lasalle, M, Sahpazova, E, Abazi, N, Ristoka Bojkovska, N, von Gersdorff, G, Scholz, C, Tönshoff, B, Krupka, K, Höcker, B, Pape, L, Afentakis, N, Kapogiannis, A, Printza, N, Reusz, G, Berecki, Cs, Szabó, A, Szabó, T, Györke, Z.S., Kis, E., Palsson, R., Edvardsson, V., Gianoglio, B., Maringhini, S., Pecoraro, C., Picca, S., Testa, S., Vidal, E., Verrina, E., Jankauskiene, A., Pundziene, B., Said-Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Zurowska, A., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Molchanova, E.A., Tomilina, N.A., Bikbov, B.T., Kostic, M., Peco-Antic, A., Spasojevic-Dimitrijeva, B., Milosevski-Lomic, G., Paripovic, D., Puric, S., Kruscic, D., Podracka, L., Kolvek, G., Buturovic-Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K.G., Backmän, L., Stendahl, M., Evans, M., Rippe, B., Kuenhi, C.E., Maurer, E., Laube, G.F., Tschumi, S., Parvex, P., Hoitsma, A., Hemke, A., Topaloglu, R., Duzova, A., Ivanov, D., Pruthi, R., Braddon, F., Mannings, S., Cassula, A., Sinha, M.D., Mekahli, Djalila, van Stralen, Karlijn J., Bonthuis, Marjolein, Jager, Kitty J., Balat, Ayşe, Benetti, Elisa, Godefroid, Nathalie, Edvardsson, Vidar O., Heaf, James G., Jankauskiene, Augustina, Kerecuk, Larissa, Marinova, Svetlana, Puteo, Flora, Seeman, Tomas, Zurowska, Aleksandra, Pirenne, Jacques, Schaefer, Franz, and Groothoff, Jaap W.

Published
2016
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5. Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

Author

van Blokland, I, Lanting, P, Ori, A, Vonk, J, Warmerdam, R, Herkert, J, Boulogne, F, Claringbould, A, Lopera-Maya, E, Bartels, M, Hottenga, J, Ganna, A, Karjalainen, J, Hayward, C, Fawns-Ritchie, C, Campbell, A, Porteous, D, Cirulli, E, Barrett, K, Riffle, S, Bolze, A, White, S, Tanudjaja, F, Wang, X, Ramirez, J, Lim, Y, Lu, J, Washington, N, de Geus, E, Deelen, P, Boezen, H, Franke, L, Mierau, J, Dekens, J, Nolte, I, Dijkema, M, Wiersma, H, Jankipersadsing, S, Cho, J, Loos, R, Moscati, A, Chang, Y, Choe, P, Chung, J, Ham, S, Joo, E, Jung, J, Kang, C, Kim, H, Kim, E, Lee, H, Park, S, Park, K, Park, J, Ryu, S, Song, K, Paik, N, Albillos, A, Asselta, R, Bujanda, L, Buti, M, Duga, S, Fernandez, J, Gomez, M, Invernizzi, P, Prati, D, Banales, J, Folseraas, T, Franke, A, Hov, J, Karlsen, T, Valenti, L, Degenhardt, F, Ellighaus, D, Eythorsson, E, Haraldsson, A, Helgason, D, Holm, H, Ingvarsson, R, Jonsdottir, I, Norddahl, G, Palsson, R, Saemundsdottir, J, Stefansson, K, Thorsteinsdottir, U, Gudbjartsson, D, Jonsson, H, Melsted, P, Sulem, P, Sveinbjornsson, G, Alarcon-Riquelme, M, Bernardo, D, Rello, S, Martinez-Bueno, M, Amtrano, S, Bruttini, M, Floriana, V, Giliberti, A, Benetti, E, Fallerini, C, Furini, S, Pinto, A, Baldassarri, M, Fava, F, Mari, F, Renieri, A, Croci, S, Tita, R, Frullanti, E, Altshul, D, Huang, Q, Hunt, K, Martin, H, Mason, D, Trembath, R, Trivedi, B, Wright, J, Finer, S, Griffiths, C, van Heel, D, Jannes, C, Krieger, J, Pereira, A, Marques, E, Dalton, K, Deboever, C, Jimenez-Morales, D, Palomera, A, Pinsky, B, Smith, E, Szalma, S, Tralau-Stewart, C, Wong, E, Gorzynski, J, de Jong, H, Amar, D, Delaneau, O, Hughes, C, Ioannidis, A, Raja, A, Rubinacci, S, Tanigawa, Y, Ashley, E, Bustamante, C, Parikh, V, Rivas, M, Wheeler, M, Busson, A, Goffard, J, Migeotte, I, Peyrassol, X, Smits, G, Vandernoot, I, Wilkin, F, Bouysran, Y, Pichon, B, Tiembe, N, Green, R, Karlson, B, Meigs, J, Mercader, J, Murphy, S, Perez, E, Slaugenhaupt, S, Smoller, J, Weiss, S, Woolley, A, Feng, Y, Nivard, M, Brusco, A, Bulik, C, Franchimont, D, Landen, M, Louis, E, Pedersen, N, Rahmouni, S, Striano, P, Vermeire, S, Zara, F, Al-Muftah, W, Badji, R, Ismail, S, Al-Sarraj, Y, Mbarek, H, Arumugam, P, Caulfield, M, Need, A, Oscroft, T, Rendon, A, Scott, R, Chan, G, Kousathanas, A, Moutsianas, L, Odhams, C, Pasko, D, Rhodes, D, Stuckey, A, Atkinson, E, Baya, N, Butler-Laporte, G, Finucane, H, Forgetta, V, Kanai, M, Karczewski, K, Koelling, N, Martin, A, Nakanishi, T, Palmer, D, Richards, J, Spencer, C, Turley, P, Walters, R, Wilson, D, Armstrong, J, O'Connell, A, Wyllie, D, Bryant, S, Churchhouse, C, Di Angelantonio, E, Chapman, M, Danesh, J, Ouwehand, W, Roberts, D, Watkins, N, Butterworth, A, Zhao, J, Biesecker, L, Davis, L, Kerchberger, E, Lee, S, Priest, J, Richards, B, Sankaran, V, Chwialkowska, K, Francescatto, M, Stevens, C, Trankiem, A, Balaconis, K, Liao, R, Daly, M, Neale, B, Bernasconi, A, Ceri, S, Cordioli, M, Niemi, M, Zhou, W, Nguyen, H, Solomonson, M, Gopalan, S, Hou, K, Jansen, P, de Leeuw, C, Lu, Z, Mancuso, N, Marouli, E, Papadopoulou, A, Pasaniuc, B, Pathak, G, Polimanti, R, Posthuma, D, Savage, J, Uffelmann, E, Visscher, P, Wendt, F, Wray, N, Yengo, L, van Blokland I. V., Lanting P., Ori A. P. S., Vonk J. M., Warmerdam R. C. A., Herkert J. C., Boulogne F., Claringbould A., Lopera-Maya E. A., Bartels M., Hottenga J. -J., Ganna A., Karjalainen J., Hayward C., Fawns-Ritchie C., Campbell A., Porteous D., Cirulli E. T., Barrett K. M. S., Riffle S., Bolze A., White S., Tanudjaja F., Wang X., Ramirez J. M., Lim Y. W., Lu J. T., Washington N. L., de Geus E. J. C., Deelen P., Boezen H. M., Franke L. H., Mierau J. O., Dekens J., Nolte I., Dijkema M. X. L., Wiersma H. H., Jankipersadsing S. A., Cho J. H., Loos R. J. F., Moscati A., Chang Y., Choe P. G., Chung J., Ham S., Joo E. -J., Jung J., Kang C. K., Kim H. -L., Kim H. B., Kim E. S., Lee H. -J., Park S., Park K. -U., Park J. S., Ryu S., Song K. -H., Kim H. -N., Paik N. -J., Albillos A., Asselta R., Bujanda L., Buti M., Duga S., Fernandez J., Gomez M. R., Invernizzi P., Prati D., Banales J. M., Folseraas T., Franke A., Hov J. R., Karlsen T. H., Valenti L., Degenhardt F., Ellighaus D., Eythorsson E. S., Haraldsson A., Helgason D., Holm H., Ingvarsson R. F., Jonsdottir I., Norddahl G. L., Palsson R., Saemundsdottir J., Stefansson K., Thorsteinsdottir U., Gudbjartsson D. F., Jonsson H., Melsted P., Sulem P., Sveinbjornsson G., Alarcon-Riquelme M. E., Bernardo D., Rello S. R., Martinez-Bueno M., Amtrano S., Bruttini M., Floriana V., Giliberti A. R., Benetti E., Fallerini C., Furini S., Pinto A. M., Baldassarri M., Fava F., Mari F., Renieri A., Croci S., Tita R., Frullanti E., Altshul D., Huang Q., Hunt K. A., Martin H. C., Mason D., Trembath R. C., Trivedi B., Wright J., Finer S., Griffiths C., van Heel D. A., Jannes C. E., Krieger J. E., Pereira A. C., Marques E., Dalton K., DeBoever C., Jimenez-Morales D., Palomera A. C., Pinsky B., Smith E., Szalma S., Tralau-Stewart C., Wong E., Gorzynski J., de Jong H., Amar D., Delaneau O., Hughes C., Ioannidis A., Raja A., Rubinacci S., Tanigawa Y., Ashley E., Bustamante C., Parikh V., Rivas M., Wheeler M., Busson A., Goffard J. -C., Migeotte I., Peyrassol X., Smits G., Vandernoot I., Wilkin F., Bouysran Y., Pichon B., Tiembe N., Green R., Karlson B., Meigs J., Mercader J., Murphy S., Perez E., Slaugenhaupt S., Smoller J., Weiss S., Woolley A., Feng Y. -C. A., Nivard M. G., Brusco A., Bulik C. M., Franchimont D., Landen M., Louis E., Pedersen N., Rahmouni S., Striano P., Vermeire S., Zara F., Al-Muftah W., Badji R., Ismail S., Al-Sarraj Y., Mbarek H., Arumugam P., Caulfield M., Need A. C., Oscroft T., Rendon A., Scott R. H., Chan G., Kousathanas A., Moutsianas L., Odhams C. A., Pasko D., Rhodes D., Stuckey A., Atkinson E. G., Baya N., Butler-Laporte G., Finucane H., Forgetta V., Kanai M., Karczewski K. J., Koelling N., Martin A. R., Nakanishi T., Palmer D. S., Richards J. B., Spencer C. C. A., Turley P., Walters R. K., Wilson D. J., Armstrong J., O'Connell A. M., Wyllie D. H., Bryant S., Churchhouse C., Di Angelantonio E., Chapman M., Danesh J., Ouwehand W., Roberts D., Watkins N., Butterworth A., Zhao J. H., Biesecker L., Davis L., van Heel D., Kerchberger E., Lee S., Priest J., Richards B., Sankaran V., Chwialkowska K., Francescatto M., Stevens C., Trankiem A., Balaconis K., Liao R., Daly M., Neale B., Bernasconi A., Ceri S., Cordioli M., Niemi M., Zhou W., Nguyen H., Solomonson M., Gopalan S., Hou K., Jansen P., de Leeuw C., Lu Z., Mancuso N., Marouli E., Papadopoulou A., Pasaniuc B., Pathak G., Polimanti R., Posthuma D., Savage J., Uffelmann E., Visscher P., Wendt F. R., Wray N., Yengo L., van Blokland, I, Lanting, P, Ori, A, Vonk, J, Warmerdam, R, Herkert, J, Boulogne, F, Claringbould, A, Lopera-Maya, E, Bartels, M, Hottenga, J, Ganna, A, Karjalainen, J, Hayward, C, Fawns-Ritchie, C, Campbell, A, Porteous, D, Cirulli, E, Barrett, K, Riffle, S, Bolze, A, White, S, Tanudjaja, F, Wang, X, Ramirez, J, Lim, Y, Lu, J, Washington, N, de Geus, E, Deelen, P, Boezen, H, Franke, L, Mierau, J, Dekens, J, Nolte, I, Dijkema, M, Wiersma, H, Jankipersadsing, S, Cho, J, Loos, R, Moscati, A, Chang, Y, Choe, P, Chung, J, Ham, S, Joo, E, Jung, J, Kang, C, Kim, H, Kim, E, Lee, H, Park, S, Park, K, Park, J, Ryu, S, Song, K, Paik, N, Albillos, A, Asselta, R, Bujanda, L, Buti, M, Duga, S, Fernandez, J, Gomez, M, Invernizzi, P, Prati, D, Banales, J, Folseraas, T, Franke, A, Hov, J, Karlsen, T, Valenti, L, Degenhardt, F, Ellighaus, D, Eythorsson, E, Haraldsson, A, Helgason, D, Holm, H, Ingvarsson, R, Jonsdottir, I, Norddahl, G, Palsson, R, Saemundsdottir, J, Stefansson, K, Thorsteinsdottir, U, Gudbjartsson, D, Jonsson, H, Melsted, P, Sulem, P, Sveinbjornsson, G, Alarcon-Riquelme, M, Bernardo, D, Rello, S, Martinez-Bueno, M, Amtrano, S, Bruttini, M, Floriana, V, Giliberti, A, Benetti, E, Fallerini, C, Furini, S, Pinto, A, Baldassarri, M, Fava, F, Mari, F, Renieri, A, Croci, S, Tita, R, Frullanti, E, Altshul, D, Huang, Q, Hunt, K, Martin, H, Mason, D, Trembath, R, Trivedi, B, Wright, J, Finer, S, Griffiths, C, van Heel, D, Jannes, C, Krieger, J, Pereira, A, Marques, E, Dalton, K, Deboever, C, Jimenez-Morales, D, Palomera, A, Pinsky, B, Smith, E, Szalma, S, Tralau-Stewart, C, Wong, E, Gorzynski, J, de Jong, H, Amar, D, Delaneau, O, Hughes, C, Ioannidis, A, Raja, A, Rubinacci, S, Tanigawa, Y, Ashley, E, Bustamante, C, Parikh, V, Rivas, M, Wheeler, M, Busson, A, Goffard, J, Migeotte, I, Peyrassol, X, Smits, G, Vandernoot, I, Wilkin, F, Bouysran, Y, Pichon, B, Tiembe, N, Green, R, Karlson, B, Meigs, J, Mercader, J, Murphy, S, Perez, E, Slaugenhaupt, S, Smoller, J, Weiss, S, Woolley, A, Feng, Y, Nivard, M, Brusco, A, Bulik, C, Franchimont, D, Landen, M, Louis, E, Pedersen, N, Rahmouni, S, Striano, P, Vermeire, S, Zara, F, Al-Muftah, W, Badji, R, Ismail, S, Al-Sarraj, Y, Mbarek, H, Arumugam, P, Caulfield, M, Need, A, Oscroft, T, Rendon, A, Scott, R, Chan, G, Kousathanas, A, Moutsianas, L, Odhams, C, Pasko, D, Rhodes, D, Stuckey, A, Atkinson, E, Baya, N, Butler-Laporte, G, Finucane, H, Forgetta, V, Kanai, M, Karczewski, K, Koelling, N, Martin, A, Nakanishi, T, Palmer, D, Richards, J, Spencer, C, Turley, P, Walters, R, Wilson, D, Armstrong, J, O'Connell, A, Wyllie, D, Bryant, S, Churchhouse, C, Di Angelantonio, E, Chapman, M, Danesh, J, Ouwehand, W, Roberts, D, Watkins, N, Butterworth, A, Zhao, J, Biesecker, L, Davis, L, Kerchberger, E, Lee, S, Priest, J, Richards, B, Sankaran, V, Chwialkowska, K, Francescatto, M, Stevens, C, Trankiem, A, Balaconis, K, Liao, R, Daly, M, Neale, B, Bernasconi, A, Ceri, S, Cordioli, M, Niemi, M, Zhou, W, Nguyen, H, Solomonson, M, Gopalan, S, Hou, K, Jansen, P, de Leeuw, C, Lu, Z, Mancuso, N, Marouli, E, Papadopoulou, A, Pasaniuc, B, Pathak, G, Polimanti, R, Posthuma, D, Savage, J, Uffelmann, E, Visscher, P, Wendt, F, Wray, N, Yengo, L, van Blokland I. V., Lanting P., Ori A. P. S., Vonk J. M., Warmerdam R. C. A., Herkert J. C., Boulogne F., Claringbould A., Lopera-Maya E. A., Bartels M., Hottenga J. -J., Ganna A., Karjalainen J., Hayward C., Fawns-Ritchie C., Campbell A., Porteous D., Cirulli E. T., Barrett K. M. S., Riffle S., Bolze A., White S., Tanudjaja F., Wang X., Ramirez J. M., Lim Y. W., Lu J. T., Washington N. L., de Geus E. J. C., Deelen P., Boezen H. M., Franke L. H., Mierau J. O., Dekens J., Nolte I., Dijkema M. X. L., Wiersma H. H., Jankipersadsing S. A., Cho J. H., Loos R. J. F., Moscati A., Chang Y., Choe P. G., Chung J., Ham S., Joo E. -J., Jung J., Kang C. K., Kim H. -L., Kim H. B., Kim E. S., Lee H. -J., Park S., Park K. -U., Park J. S., Ryu S., Song K. -H., Kim H. -N., Paik N. -J., Albillos A., Asselta R., Bujanda L., Buti M., Duga S., Fernandez J., Gomez M. R., Invernizzi P., Prati D., Banales J. M., Folseraas T., Franke A., Hov J. R., Karlsen T. H., Valenti L., Degenhardt F., Ellighaus D., Eythorsson E. S., Haraldsson A., Helgason D., Holm H., Ingvarsson R. F., Jonsdottir I., Norddahl G. L., Palsson R., Saemundsdottir J., Stefansson K., Thorsteinsdottir U., Gudbjartsson D. F., Jonsson H., Melsted P., Sulem P., Sveinbjornsson G., Alarcon-Riquelme M. E., Bernardo D., Rello S. R., Martinez-Bueno M., Amtrano S., Bruttini M., Floriana V., Giliberti A. R., Benetti E., Fallerini C., Furini S., Pinto A. M., Baldassarri M., Fava F., Mari F., Renieri A., Croci S., Tita R., Frullanti E., Altshul D., Huang Q., Hunt K. A., Martin H. C., Mason D., Trembath R. C., Trivedi B., Wright J., Finer S., Griffiths C., van Heel D. A., Jannes C. E., Krieger J. E., Pereira A. C., Marques E., Dalton K., DeBoever C., Jimenez-Morales D., Palomera A. C., Pinsky B., Smith E., Szalma S., Tralau-Stewart C., Wong E., Gorzynski J., de Jong H., Amar D., Delaneau O., Hughes C., Ioannidis A., Raja A., Rubinacci S., Tanigawa Y., Ashley E., Bustamante C., Parikh V., Rivas M., Wheeler M., Busson A., Goffard J. -C., Migeotte I., Peyrassol X., Smits G., Vandernoot I., Wilkin F., Bouysran Y., Pichon B., Tiembe N., Green R., Karlson B., Meigs J., Mercader J., Murphy S., Perez E., Slaugenhaupt S., Smoller J., Weiss S., Woolley A., Feng Y. -C. A., Nivard M. G., Brusco A., Bulik C. M., Franchimont D., Landen M., Louis E., Pedersen N., Rahmouni S., Striano P., Vermeire S., Zara F., Al-Muftah W., Badji R., Ismail S., Al-Sarraj Y., Mbarek H., Arumugam P., Caulfield M., Need A. C., Oscroft T., Rendon A., Scott R. H., Chan G., Kousathanas A., Moutsianas L., Odhams C. A., Pasko D., Rhodes D., Stuckey A., Atkinson E. G., Baya N., Butler-Laporte G., Finucane H., Forgetta V., Kanai M., Karczewski K. J., Koelling N., Martin A. R., Nakanishi T., Palmer D. S., Richards J. B., Spencer C. C. A., Turley P., Walters R. K., Wilson D. J., Armstrong J., O'Connell A. M., Wyllie D. H., Bryant S., Churchhouse C., Di Angelantonio E., Chapman M., Danesh J., Ouwehand W., Roberts D., Watkins N., Butterworth A., Zhao J. H., Biesecker L., Davis L., van Heel D., Kerchberger E., Lee S., Priest J., Richards B., Sankaran V., Chwialkowska K., Francescatto M., Stevens C., Trankiem A., Balaconis K., Liao R., Daly M., Neale B., Bernasconi A., Ceri S., Cordioli M., Niemi M., Zhou W., Nguyen H., Solomonson M., Gopalan S., Hou K., Jansen P., de Leeuw C., Lu Z., Mancuso N., Marouli E., Papadopoulou A., Pasaniuc B., Pathak G., Polimanti R., Posthuma D., Savage J., Uffelmann E., Visscher P., Wendt F. R., Wray N., and Yengo L.

Abstract

Epidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2 infection. Recently, it was shown that it is possible to predict COVID-19 cases using cross-sectional self-reported disease-related symptoms. Here, we demonstrate that this COVID-19 prediction model has reasonable and consistent performance across multiple independent cohorts and that our attempt to improve upon this model did not result in improved predictions. Using the existing COVID- 19 prediction model, we then conducted a GWAS on the predicted phenotype using a total of 1,865 predicted cases and 29,174 controls. While we did not find any common, largeeffect variants that reached genome-wide significance, we do observe suggestive genetic associations at two SNPs (rs11844522, p = 1.9x10-7; rs5798227, p = 2.2x10-7). Explorative analyses furthermore suggest that genetic variants associated with other viral infectious diseases do not overlap with COVID-19 susceptibility and that severity of COVID-19 may have a different genetic architecture compared to COVID-19 susceptibility. This study represents a first effort that uses a symptom-based predicted phenotype as a proxy for COVID-19 in our pursuit of understanding the genetic susceptibility of the disease. We conclude that the inclusion of symptom-based predicted cases could be a useful strategy in a scenario of limited testing, either during the current COVID-19 pandemic or any future viral outbreak.

Published
2021

9. Identification of subgroups by risk of graft failure after paediatric renal transplantation: application of survival tree models on the ESPN/ERA-EDTA Registry

Author

Lofaro, Danilo, Jager, Kitty J., Abu-Hanna, Ameen, Groothoff, Jaap W., Arikoski, Pekka, Hoecker, Britta, Roussey-Kesler, Gwenaelle, Spasojević, Brankica, Verrina, Enrico, Schaefer, Franz, van Stralen, Karlijn J., Coppo, R., Haffner, D., Harambat, J., Stefanidis, C., Shitza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., van Hoeck, K., Collart, F., des Grottes, J.M., Pokrajac, D., Resić, H., Prnjavorac, B., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J.G., Toots, U., Finne, P., Grönhagen-Riska, C., Couchoud, C., Lasalle, M., Sahpazova, E., Gersdorf, G., Barth, C., Scholz, C., Tönshoff, B., Ioannidis, G., Kapogiannis, A., Papachristou, F., Reusz, G., Túri, S., Szabó, L., Szabó, T., Reusz, G., Györke, Zs., Kis, E., Palsson, R., Edvardsson, V., Mencarelli, F., Paglialonga, F., Pecoraro, C., Picca, S., Roperto, R., Vidal, E., Verrina, E., Jankauskiene, A., Pundziene, B., Said-Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Bjerre, A., Zurowska, A., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Podgoreanu, E., Molchanova, E.A., Tomilina, N.A., Bikbov, B.T., Kostic, M., Peco-Antic, A., Puric, S., Kruscic, D., Spasojevic-Dimitrijeva, B., Milosecski-Lomic, G., Paripovic, D., Podracka, L., Kolvek, G., Buturovic-Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K.G., Seeberger, A., Backmän, L., Evans, M., Kuenhi, C.E., Maurer, E., Laube, G., Simometi, G., Hoitsma, A., Hemke, A., Topaloglu, R., Duzova, A., Ivanov, D., and Sinha, M.

Published
2016
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10. U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery

Author

Metcalf, R.G., Skuladottir, G.V., Indridason, O.S., Sullivan, T.R., Bjorgvinsdottir, L., Sanders, P., Arnar, D.O., Gibson, R.A., Heidarsdottir, R., Cleland, L.G., Palsson, R., Farquharson, A.L., Young, G.D., and James, M.J.

Subjects
Physiological aspects, Complications and side effects, Heart surgery -- Complications and side effects, Atrial fibrillation -- Physiological aspects, Medical research, Medicine, Experimental, Heart -- Surgery
Abstract

INTRODUCTION Atrial fibrillation (AF) is a common postoperative complication of cardiac surgery, which is associated with increased length of hospital or intensive care unit (ICU) stay and increased morbidity and [...], BACKGROUND/OBJECTIVES: Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and the incidence of POAF. SUBJECTS/METHODS: We used combined data (n = 355) from RCTs conducted in Australia and Iceland. The primary end point was defined as POAF lasting >10min in the first 6 days following surgery. The odds ratios (ORs) for POAF were compared between quintiles of preoperative RBC n-3 LC-PUFA levels by multivariable logistic regression. RESULTS: Subjects with RBC docosahexaenoic acid (DHA) in the fourth quintile, comprising a RBC DHA range of 7.0-7.9%, had the lowest incidence of POAF. Subjects in the lowest and highest quintiles had significantly higher risk of developing POAF compared with those in the fourth quintile (OR = 2.36: 95% CI; 1.07-5.24 and OR = 2.45: 95% CI; 1.16-5.17, respectively). There was no association between RBC eicosapentaenoic acid levels and POAF incidence. CONCLUSIONS: The results suggest a 'U-shaped' relationship between RBC DHA levels and POAF incidence. The possibility of increased risk of POAF at high levels of DHA suggests an upper limit for n-3 LC-PUFAs in certain conditions. European Journal of Clinical Nutrition (2014) 68, 114-118; doi: 10.1038/ejcn.2013.215; published online 30 October 2013 Keywords: omega-3 fatty acids; docosahexaenoic acid; atrial fibrillation; cardiac surgery

Published
2014
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12. Beating the odds with systematic individualized care: Nationwide prospective follow‐up of all patients with COVID‐19 in Iceland

Author

Helgason, D., primary, Eythorsson, E., additional, Olafsdottir, L. B., additional, Agustsson, T., additional, Ingvarsdottir, S., additional, Sverrisdottir, S., additional, Ragnarsdottir, E. D., additional, Gottfredsson, M., additional, Gudlaugsson, O., additional, Palsson, R., additional, and Ingvarsson, R. F., additional

Published
2020
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14. CKD: A Call for an Age-Adapted Definition

Author

Delanaye, P., Jager, K.J., Bokenkamp, A., Christensson, A., Dubourg, L., Eriksen, B.O., Gaillard, F., Gambaro, G., Giet, M. van der, Glassock, R.J., Indridason, O.S., Londen, M. van, Mariat, C., Melsom, T., Moranne, O., Nordin, G., Palsson, R., Pottel, H., Rule, A.D., Schaeffner, E., Taal, M.W., White, C., Grubb, A., Brand, J. van den, Delanaye, P., Jager, K.J., Bokenkamp, A., Christensson, A., Dubourg, L., Eriksen, B.O., Gaillard, F., Gambaro, G., Giet, M. van der, Glassock, R.J., Indridason, O.S., Londen, M. van, Mariat, C., Melsom, T., Moranne, O., Nordin, G., Palsson, R., Pottel, H., Rule, A.D., Schaeffner, E., Taal, M.W., White, C., Grubb, A., and Brand, J. van den

Abstract

Item does not contain fulltext, Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m(2) This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that GFR declines with healthy aging without any overt signs of compensation (such as elevated single-nephron GFR) or kidney damage. Older living kidney donors, who are carefully selected based on good health, have a lower predonation GFR compared with younger donors. Furthermore, the results from the large meta-analyses conducted by the CKD Prognosis Consortium and from numerous other studies indicate that the GFR threshold above which the risk of mortality is increased is not consistent across all ages. Among younger persons, mortality is increased at GFR <75 ml/min per 1.73 m(2), whereas in elderly people it is increased at levels <45 ml/min per 1.73 m(2) Therefore, we suggest that amending the CKD definition to include age-specific thresholds for GFR. The implications of an updated definition are far reaching. Having fewer healthy elderly individuals diagnosed with CKD could help reduce inappropriate care and its associated adverse effects. Global prevalence estimates for CKD would be substantially reduced. Also, using an age-specific threshold for younger persons might lead to earlier identification of CKD onset for such individuals, at a point when progressive kidney damage may still be preventable.

Published
2019

15. Beating the odds with systematic individualized care: Nationwide prospective follow‐up of all patients with COVID‐19 in Iceland.

Author

Helgason, D., Eythorsson, E., Olafsdottir, L. B., Agustsson, T., Ingvarsdottir, S., Sverrisdottir, S., Ragnarsdottir, E. D., Gottfredsson, M., Gudlaugsson, O., Palsson, R., and Ingvarsson, R. F.

Subjects
COVID-19, SARS-CoV-2, MEDICAL personnel
Abstract

Beating the odds with systematic individualized care: Nationwide prospective follow-up of all patients with COVID-19 in Iceland The current pandemic of a novel coronavirus disease 2019 (COVID-19) began in December 2019 in Wuhan, China, and has since spread worldwide [1]. In mid-January 2020, the Directorate of Health (DOH) and the Department of Civil Protection and Emergency Management (DCPEM) revised the current pandemic preparedness response plan. [Extracted from the article]

Published
2021
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16. Mortality due to bleeding, myocardial infarction and stroke in dialysis patients

Author

Ocak, G, Noordzij, M, Rookmaaker, M B, Cases, A, Couchoud, C, Heaf, J G, Jarraya, F, De Meester, J, Groothoff, J W, Waldum-Grevbo, B E, Palsson, R, Resic, H, Remón, C, Finne, P, Stendahl, M, Verhaar, M C, Massy, Z A, Dekker, F W, Jager, K J, Ocak, G, Noordzij, M, Rookmaaker, M B, Cases, A, Couchoud, C, Heaf, J G, Jarraya, F, De Meester, J, Groothoff, J W, Waldum-Grevbo, B E, Palsson, R, Resic, H, Remón, C, Finne, P, Stendahl, M, Verhaar, M C, Massy, Z A, Dekker, F W, and Jager, K J

Abstract

Essentials Mortality due to bleeding vs. arterial thrombosis in dialysis patients is unknown. We compared death causes of 201 918 dialysis patients with the general population. Dialysis was associated with increased mortality risks of bleeding and arterial thrombosis. Clinicians should be aware of the increased bleeding and thrombosis risks.SUMMARY: Background Dialysis has been associated with both bleeding and thrombotic events. However, there is limited information on bleeding as a cause of death versus arterial thrombosis as a cause of death. Objectives To investigate the occurrence of bleeding, myocardial infarction and stroke as causes of death in the dialysis population as compared with the general population. Methods We included 201 918 patients from 11 countries providing data to the ERA-EDTA Registry who started dialysis treatment between 1994 and 2011, and followed them for 3 years. Age-standardized and sex-standardized mortality rate ratios for bleeding, myocardial infarction and stroke as causes of death were calculated in dialysis patients as compared with the European general population. Associations between potential risk factors and these causes of death in dialysis patients were investigated by calculating hazard ratios (HRs) with 95% confidence intervals (CIs) by the use of Cox proportional-hazards regression. Results As compared with the general population, the age-standardized and sex-standardized mortality rate ratios in dialysis patients were 12.8 (95% CI 11.9-13.7) for bleeding as a cause of death (6.2 per 1000 person-years among dialysis patients versus 0.3 per 1000 person-years in the general population), 13.4 (95% CI 13.0-13.9) for myocardial infarction (22.5 versus 0.9 per 1000 person-years), and 12.4 (95% CI 11.9-12.9) for stroke (14.3 versus 0.7 per 1000 person-years). Conclusion Dialysis patients have highly increased risks of death caused by bleeding and arterial thrombosis as compared with the general population. Clinicians

Published
2018

17. Infants Requiring Maintenance Dialysis: Outcomes of Hemodialysis and Peritoneal Dialysis

Author

Vidal, Enrico, primary, van Stralen, Karlijn J., additional, Chesnaye, Nicholas C., additional, Bonthuis, Marjolein, additional, Holmberg, Christer, additional, Zurowska, Aleksandra, additional, Trivelli, Antonella, additional, Da Silva, José Eduardo Esteves, additional, Herthelius, Maria, additional, Adams, Brigitte, additional, Bjerre, Anna, additional, Jankauskiene, Augustina, additional, Miteva, Polina, additional, Emirova, Khadizha, additional, Bayazit, Aysun K., additional, Mache, Christoph J., additional, Sánchez-Moreno, Ana, additional, Harambat, Jérôme, additional, Groothoff, Jaap W., additional, Jager, Kitty J., additional, Schaefer, Franz, additional, Verrina, Enrico, additional, Shtiza, D., additional, Kramar, R., additional, Oberbauer, R., additional, Baiko, S., additional, Sukalo, A., additional, van Hoeck, K., additional, Collart, F., additional, des Grottes, J.M., additional, Pokrajac, D., additional, Roussinov, D., additional, Batinić, D., additional, Lemac, M., additional, Slavicek, J., additional, Seeman, T., additional, Vondrak, K., additional, Heaf, J.G., additional, Toots, U., additional, Finne, P., additional, Grönhagen-Riska, C., additional, Couchoud, C., additional, Lasalle, M., additional, Sahpazova, E., additional, Abazi, N., additional, Ristoka Bojkovska, N., additional, von Gersdorff, G., additional, Scholz, C., additional, Tönshoff, B., additional, Krupka, K., additional, Höcker, B., additional, Pape, L., additional, Afentakis, N., additional, Kapogiannis, A., additional, Printza, N., additional, Reusz, G., additional, Berecki, C.S., additional, Szabó, A., additional, Szabó, T., additional, Györke, Z.S., additional, Kis, E., additional, Palsson, R., additional, Edvardsson, V., additional, Gianoglio, B., additional, Maringhini, S., additional, Pecoraro, C., additional, Picca, S., additional, Testa, S., additional, Rudaitis, S., additional, Said-Conti, V., additional, Gatcan, S., additional, Berbeca, O., additional, Zaikova, N., additional, Pavićević, S., additional, Leivestad, T., additional, Zagozdzon, I., additional, Mota, C., additional, Almeida, M., additional, Afonso, C., additional, Mircescu, G., additional, Garneata, L., additional, Molchanova, E.A., additional, Tomilina, N.A., additional, Bikbov, B.T., additional, Kostic, M., additional, Peco-Antic, A., additional, Spasojevic-Dimitrijeva, B., additional, Milosevski-Lomic, G., additional, Paripovic, D., additional, Puric, S., additional, Kruscic, D., additional, Podracka, L., additional, Kolvek, G., additional, Buturovic-Ponikvar, J., additional, Novljan, G., additional, Battelino, N., additional, Alonso Melgar, A., additional, Schön, S., additional, Prütz, K.G., additional, Backmän, L., additional, Stendahl, M., additional, Evans, M., additional, Rippe, B., additional, Kuenhi, C.E., additional, Maurer, E., additional, Laube, G.F., additional, Tschumi, S., additional, Parvex, P., additional, Hoitsma, A., additional, Hemke, A., additional, Topaloglu, R., additional, Ivanov, D., additional, Pruthi, R., additional, Braddon, F., additional, Mannings, S., additional, Cassula, A., additional, and Sinha, M.D., additional

Published
2017
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18. Calculating the Rate of Senescence From Mortality Data: An Analysis of Data From the ERA-EDTA Registry

Author

Koopman, J.J., Rozing, M.P., Kramer, A., Abad, J.M., Finne, P., Heaf, J.G., Hoitsma, A.J., Meester, J.M. De, Palsson, R., Postorino, M., Ravani, P., Wanner, C., Jager, K.J., Bodegom, D. van, Westendorp, R.G., Koopman, J.J., Rozing, M.P., Kramer, A., Abad, J.M., Finne, P., Heaf, J.G., Hoitsma, A.J., Meester, J.M. De, Palsson, R., Postorino, M., Ravani, P., Wanner, C., Jager, K.J., Bodegom, D. van, and Westendorp, R.G.

Abstract

Item does not contain fulltext, The rate of senescence can be inferred from the acceleration by which mortality rates increase over age. Such a senescence rate is generally estimated from parameters of a mathematical model fitted to these mortality rates. However, such models have limitations and underlying assumptions. Notably, they do not fit mortality rates at young and old ages. Therefore, we developed a method to calculate senescence rates from the acceleration of mortality directly without modeling the mortality rates. We applied the different methods to age group-specific mortality data from the European Renal Association-European Dialysis and Transplant Association Registry, including patients with end-stage renal disease on dialysis, who are known to suffer from increased senescence rates (n = 302,455), and patients with a functioning kidney transplant (n = 74,490). From age 20 to 70, senescence rates were comparable when calculated with or without a model. However, when using non-modeled mortality rates, senescence rates were yielded at young and old ages that remained concealed when using modeled mortality rates. At young ages senescence rates were negative, while senescence rates declined at old ages. In conclusion, the rate of senescence can be calculated directly from non-modeled mortality rates, overcoming the disadvantages of an indirect estimation based on modeled mortality rates.

Published
2016

19. Long-term Kidney Transplant Outcomes in Primary Glomerulonephritis: Analysis From the ERA-EDTA Registry

Author

Pippias, M., Stel, V.S., Areste-Fosalba, N., Couchoud, C., Fernandez-Fresnedo, G., Finne, P., Heaf, J.G., Hoitsma, A.J., Meester, J. de, Palsson, R., Ravani, P., Segelmark, M., Traynor, J.P., Reisaeter, A.V., Caskey, F.J., Jager, K.J., Pippias, M., Stel, V.S., Areste-Fosalba, N., Couchoud, C., Fernandez-Fresnedo, G., Finne, P., Heaf, J.G., Hoitsma, A.J., Meester, J. de, Palsson, R., Ravani, P., Segelmark, M., Traynor, J.P., Reisaeter, A.V., Caskey, F.J., and Jager, K.J.

Abstract

Item does not contain fulltext, BACKGROUND: We evaluated the 15-year kidney allograft survival in patients with primary glomerulonephritis and determined if the risk of graft loss varied with donor source within each glomerulonephritis group. METHODS: Using data from the European Renal Association-European Dialysis and Transplant Association Registry, Kaplan-Meier, competing risk, and Cox regression analyses were performed on adult, first kidney transplant recipients during 1991 to 2010 (n = 14 383). Follow-up was set to December 31, 2011. Adjustments for pretransplant dialysis duration, sex, country, and transplant era were made. "Death-adjusted graft survival" was assessed in patients with glomerulonephritis and compared with those with autosomal dominant polycystic kidney disease (ADPKD), in which the native kidney disease cannot recur. Additionally, death-adjusted graft survival was compared between living and deceased donor transplants within each glomerulonephritis group. RESULTS: All glomerulonephritides had a 15-year death-adjusted graft survival probability above 55%. The 15-year risk of death-adjusted graft failure compared to ADPKD ranged from 1.17 (95% confidence interval [95% CI], 1.05-1.31) for immunoglobulin A nephropathy to 2.09 (95% CI, 1.56-2.78) for membranoproliferative glomerulonephritis type II. The expected survival benefits of living over deceased donor transplants were not present in membranoproliferative glomerulonephritis type I (adjusted hazard ratios [HRa], 1.08; 95% CI, 0.73-1.60) or type II (HRa, 0.90; 95% CI, 0.32-2.52) but present in immunoglobulin A nephropathy (HRa, 0.74; 95% CI, 0.59-0.92), membranous nephropathy (HRa, 0.47; 95% CI, 0.29-0.75), and focal segmental glomerulosclerosis (HRa, 0.69; 95% CI, 0.45-1.06). CONCLUSIONS: This large European study shows favorable long-term kidney graft survival in all primary glomerulonephritides, although this remains lower than graft survival in ADPKD, and confirms that the reluctance to use living donors in some primary

Published
2016

20. Kidney Versus Combined Kidney and Liver Transplantation in Young People With Autosomal Recessive Polycystic Kidney Disease: Data From the European Society for Pediatric Nephrology/European Renal Association−European Dialysis and Transplant (ESPN/ERA-EDTA) Registry

Author

Mekahli, Djalila, primary, van Stralen, Karlijn J., additional, Bonthuis, Marjolein, additional, Jager, Kitty J., additional, Balat, Ayşe, additional, Benetti, Elisa, additional, Godefroid, Nathalie, additional, Edvardsson, Vidar O., additional, Heaf, James G., additional, Jankauskiene, Augustina, additional, Kerecuk, Larissa, additional, Marinova, Svetlana, additional, Puteo, Flora, additional, Seeman, Tomas, additional, Zurowska, Aleksandra, additional, Pirenne, Jacques, additional, Schaefer, Franz, additional, Groothoff, Jaap W., additional, Levtchenko, E., additional, Haffner, D., additional, Bjerre, A., additional, Massy, Z., additional, Shtiza, D., additional, Kramar, R., additional, Oberbauer, R., additional, Baiko, S., additional, Sukalo, A., additional, van Hoeck, K., additional, Collart, F., additional, des Grottes, J.M., additional, Pokrajac, D., additional, Roussinov, D., additional, Batinić, D., additional, Lemac, M., additional, Slavicek, J., additional, Seeman, T., additional, Vondrak, K., additional, Heaf, J.G., additional, Toots, U., additional, Finne, P., additional, Grönhagen-Riska, C., additional, Couchoud, C., additional, Lasalle, M, additional, Sahpazova, E, additional, Abazi, N, additional, Ristoka Bojkovska, N, additional, von Gersdorff, G, additional, Scholz, C, additional, Tönshoff, B, additional, Krupka, K, additional, Höcker, B, additional, Pape, L, additional, Afentakis, N, additional, Kapogiannis, A, additional, Printza, N, additional, Reusz, G, additional, Berecki, Cs, additional, Szabó, A, additional, Szabó, T, additional, Györke, Z.S., additional, Kis, E., additional, Palsson, R., additional, Edvardsson, V., additional, Gianoglio, B., additional, Maringhini, S., additional, Pecoraro, C., additional, Picca, S., additional, Testa, S., additional, Vidal, E., additional, Verrina, E., additional, Jankauskiene, A., additional, Pundziene, B., additional, Said-Conti, V., additional, Gatcan, S., additional, Berbeca, O., additional, Zaikova, N., additional, Pavićević, S., additional, Leivestad, T., additional, Zurowska, A., additional, Zagozdzon, I., additional, Mota, C., additional, Almeida, M., additional, Afonso, C., additional, Mircescu, G., additional, Garneata, L., additional, Molchanova, E.A., additional, Tomilina, N.A., additional, Bikbov, B.T., additional, Kostic, M., additional, Peco-Antic, A., additional, Spasojevic-Dimitrijeva, B., additional, Milosevski-Lomic, G., additional, Paripovic, D., additional, Puric, S., additional, Kruscic, D., additional, Podracka, L., additional, Kolvek, G., additional, Buturovic-Ponikvar, J., additional, Novljan, G., additional, Battelino, N., additional, Alonso Melgar, A., additional, Schön, S., additional, Prütz, K.G., additional, Backmän, L., additional, Stendahl, M., additional, Evans, M., additional, Rippe, B., additional, Kuenhi, C.E., additional, Maurer, E., additional, Laube, G.F., additional, Tschumi, S., additional, Parvex, P., additional, Hoitsma, A., additional, Hemke, A., additional, Topaloglu, R., additional, Duzova, A., additional, Ivanov, D., additional, Pruthi, R., additional, Braddon, F., additional, Mannings, S., additional, Cassula, A., additional, and Sinha, M.D., additional

Published
2016
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25. Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report

Author

Pippias, M., Stel, V.S., Diez, J.M. Abad, Afentakis, N., Herrero-Calvo, J.A., Arias, M., Tomilina, N., Caamano, E. Bouzas, Buturovic-Ponikvar, J., Cala, S., Caskey, F.J., Nuez, P. Castro de la, Cernevskis, H., Collart, F., Torre, R. Alonso de la, Mde, L. Hoya, Meester, J. de, Diaz, J.M., Djukanovic, L., Alamar, M. Ferrer, Finne, P., Garneata, L., Golan, E., Fernandez, R., Avila, G. Gutierrez, Heaf, J., Hoitsma, A.J., Kantaria, N., Kolesnyk, M., Kramar, R., Kramer, A., Lassalle, M., Leivestad, T., Lopot, F., Macario, F., Magaz, A., Martin-Escobar, E., Metcalfe, W., Noordzij, M., Palsson, R., Pechter, U., Prutz, K.G., Ratkovic, M., Resic, H., Rutkowski, B., Pablos, C. Santiuste de, Spustova, V., Suleymanlar, G., Stralen, K. Van, Thereska, N., Wanner, C., Jager, K.J., Pippias, M., Stel, V.S., Diez, J.M. Abad, Afentakis, N., Herrero-Calvo, J.A., Arias, M., Tomilina, N., Caamano, E. Bouzas, Buturovic-Ponikvar, J., Cala, S., Caskey, F.J., Nuez, P. Castro de la, Cernevskis, H., Collart, F., Torre, R. Alonso de la, Mde, L. Hoya, Meester, J. de, Diaz, J.M., Djukanovic, L., Alamar, M. Ferrer, Finne, P., Garneata, L., Golan, E., Fernandez, R., Avila, G. Gutierrez, Heaf, J., Hoitsma, A.J., Kantaria, N., Kolesnyk, M., Kramar, R., Kramer, A., Lassalle, M., Leivestad, T., Lopot, F., Macario, F., Magaz, A., Martin-Escobar, E., Metcalfe, W., Noordzij, M., Palsson, R., Pechter, U., Prutz, K.G., Ratkovic, M., Resic, H., Rutkowski, B., Pablos, C. Santiuste de, Spustova, V., Suleymanlar, G., Stralen, K. Van, Thereska, N., Wanner, C., and Jager, K.J.

Abstract

Contains fulltext : 155733.pdf (Publisher’s version ) (Open Access), BACKGROUND: This article summarizes the 2012 European Renal Association-European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as >/=65 years). METHODS: Data provided by 45 national or regional renal registries in 30 countries in Europe and bordering the Mediterranean Sea were used. Individual patient level data were received from 31 renal registries, whereas 14 renal registries contributed data in an aggregated form. The incidence, prevalence and survival probabilities of patients with end-stage renal disease (ESRD) receiving renal replacement therapy (RRT) and renal transplantation rates for 2012 are presented. RESULTS: In 2012, the overall unadjusted incidence rate of patients with ESRD receiving RRT was 109.6 per million population (pmp) (n = 69 035), ranging from 219.9 pmp in Portugal to 24.2 pmp in Montenegro. The proportion of incident patients >/=75 years varied from 15 to 44% between countries. The overall unadjusted prevalence on 31 December 2012 was 716.7 pmp (n = 451 270), ranging from 1670.2 pmp in Portugal to 146.7 pmp in the Ukraine. The proportion of prevalent patients >/=75 years varied from 11 to 32% between countries. The overall renal transplantation rate in 2012 was 28.3 pmp (n = 15 673), with the highest rate seen in the Spanish region of Catalonia. The proportion of patients >/=65 years receiving a transplant ranged from 0 to 35%. Five-year adjusted survival for all RRT patients was 59.7% (95% confidence interval, CI: 59.3-60.0) which fell to 39.3% (95% CI: 38.7-39.9) in patients 65-74 years and 21.3% (95% CI: 20.8-21.9) in patients >/=75 years.

Published
2015

26. Mortality from infections and malignancies in patients treated with renal replacement therapy: data from the ERA-EDTA registry

Author

Vogelzang, J.L., Stralen, K.J. van, Noordzij, M., Diez, J.A., Carrero, J.J., Couchoud, C., Dekker, F.W., Finne, P., Fouque, D., Heaf, J.G., Hoitsma, A.J., Leivestad, T., Meester, J. de, Metcalfe, W., Palsson, R., Postorino, M., Ravani, P., Vanholder, R., Wallner, M., Wanner, C., Groothoff, J.W., Jager, K.J., Vogelzang, J.L., Stralen, K.J. van, Noordzij, M., Diez, J.A., Carrero, J.J., Couchoud, C., Dekker, F.W., Finne, P., Fouque, D., Heaf, J.G., Hoitsma, A.J., Leivestad, T., Meester, J. de, Metcalfe, W., Palsson, R., Postorino, M., Ravani, P., Vanholder, R., Wallner, M., Wanner, C., Groothoff, J.W., and Jager, K.J.

Abstract

Item does not contain fulltext, BACKGROUND: Infections and malignancies are the most common non-cardiovascular causes of death in patients on chronic renal replacement therapy (RRT). Here, we aimed to quantify the mortality risk attributed to infections and malignancies in dialysis patients and kidney transplant recipients when compared with the general population by age group and sex. METHODS: We followed 168 156 patients included in the ERA-EDTA registry who started RRT in 1993-2007 until 1 January 2012. Age- and cause-specific mortality rates per 1000 person-years (py) and mortality rate ratios (MRRs) compared with the European general population (WHO) were calculated. To identify risk factors, we used Cox regression. RESULTS: Infection-related mortality was increased 82-fold in dialysis patients and 32-fold in transplant recipients compared with the general population. Female sex, diabetes, cancer and multisystem disease were associated with an increased risk of infection-related mortality. The sex difference was most pronounced for dialysis patients aged 0-39 years, with women having a 32% (adjusted HR 1.32 95% CI 1.09-1.60) higher risk of infection-related mortality than men. Mortality from malignancies was 2.9 times higher in dialysis patients and 1.7 times higher in transplant recipients than in the general population. Cancer and multisystem disease as primary causes of end-stage renal disease were associated with higher mortality from malignancies. CONCLUSION: Infection-related mortality is highly increased in dialysis and kidney transplant patients, while the risk of malignancy-related death is moderately increased. Young women on dialysis may deserve special attention because of their high excess risk of infection-related mortality. Further research into the mechanisms, prevention and optimal treatment of infections in this vulnerable population is required.

Published
2015

27. Mortality from infections and malignancies in patients treated with renal replacement therapy: data from the ERA-EDTA registry

Author

Vogelzang, J. L., primary, van Stralen, K. J., additional, Noordzij, M., additional, Diez, J. A., additional, Carrero, J. J., additional, Couchoud, C., additional, Dekker, F. W., additional, Finne, P., additional, Fouque, D., additional, Heaf, J. G., additional, Hoitsma, A., additional, Leivestad, T., additional, de Meester, J., additional, Metcalfe, W., additional, Palsson, R., additional, Postorino, M., additional, Ravani, P., additional, Vanholder, R., additional, Wallner, M., additional, Wanner, C., additional, Groothoff, J. W., additional, and Jager, K. J., additional

Published
2015
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28. Renal replacement therapy for rare diseases affecting the kidney: an analysis of the ERA-EDTA Registry

Author

Wuhl, E., Stralen, K.J. van, Wanner, C., Ariceta, G., Heaf, J.G., Bjerre, A.K., Palsson, R., Duneau, G., Hoitsma, A.J., Ravani, P., Schaefer, F., Jager, K.J., Wuhl, E., Stralen, K.J. van, Wanner, C., Ariceta, G., Heaf, J.G., Bjerre, A.K., Palsson, R., Duneau, G., Hoitsma, A.J., Ravani, P., Schaefer, F., and Jager, K.J.

Abstract

Item does not contain fulltext, BACKGROUND: In recent years, increased efforts have been undertaken to address the needs of patients with rare diseases by international initiatives and consortia devoted to rare disease research and management. However, information on the overall prevalence of rare diseases within the end-stage renal disease (ESRD) population is limited. The aims of this study were (i) to identify those rare diseases within the ERA-EDTA Registry for which renal replacement therapy (RRT) is being provided and (ii) to determine the prevalence and incidence of RRT for ESRD due to rare diseases, both overall and separately for children and adults. METHODS: The Orphanet classification of rare disease was searched for rare diseases potentially causing ESRD, and these diagnosis codes were mapped to the corresponding ERA-EDTA primary renal disease codes. Thirty-one diagnoses were defined as rare diseases causing ESRD. RESULTS: From 1 January 2007 to 31 December 2011, 7194 patients started RRT for a rare disease (10.6% children). While some diseases were exclusively found in adults (e.g. Fabry disease), primary oxalosis, cystinosis, congenital anomalies of the kidney and urinary tract (CAKUT) and medullary cystic kidney disease affected young patients in up to 46%. On 31 December 2011, 20 595 patients (12.4% of the total RRT population) were on RRT for ESRD caused by a rare disease. The point prevalence was 32.5 per million age-related population in children and 152.0 in adults. Only 5.8% of these patients were younger than 20 years; however, 57.7% of all children on RRT had a rare disease, compared with only 11.9% in adults. CAKUT and focal segmental glomerulosclerosis were the most prevalent rare disease entities among patients on RRT. CONCLUSIONS: More than half of all children and one of nine adults on RRT in the ERA-EDTA Registry suffer from kidney failure due to a rare disease, potentially with a large number of additional undiagnosed or miscoded cases. Comprehensive diagnostic assess

Published
2014

30. Renal replacement therapy in Europe: a summary of the 2011 ERA-EDTA Registry Annual Report

Author

Noordzij, M., primary, Kramer, A., additional, Abad Diez, J. M., additional, Alonso de la Torre, R., additional, Arcos Fuster, E., additional, Bikbov, B. T., additional, Bonthuis, M., additional, Bouzas Caamano, E., additional,  ala, S., additional, Caskey, F. J., additional, Castro de la Nuez, P., additional, Cernevskis, H., additional, Collart, F., additional, Diaz Tejeiro, R., additional, Djukanovic, L., additional, Ferrer-Alamar, M., additional, Finne, P., additional, Garcia Bazaga, M. d. l. A., additional, Garneata, L., additional, Golan, E., additional, Gonzalez Fernandez, R., additional, Heaf, J. G., additional, Hoitsma, A., additional, Ioannidis, G. A., additional, Kolesnyk, M., additional, Kramar, R., additional, Lasalle, M., additional, Leivestad, T., additional, Lopot, F., additional, van de Luijtgaarden, M. W. M., additional, Macario, F., additional, Magaz, A., additional, Martin Escobar, E., additional, de Meester, J., additional, Metcalfe, W., additional, Ots-Rosenberg, M., additional, Palsson, R., additional, Pinera, C., additional, Pippias, M., additional, Prutz, K. G., additional, Ratkovic, M., additional, Resi , H., additional, Rodriguez Hernandez, A., additional, Rutkowski, B., additional, Spustova, V., additional, Stel, V. S., additional, Stojceva-Taneva, O., additional, Suleymanlar, G., additional, Wanner, C., additional, and Jager, K. J., additional

Published
2014
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31. Timing and Outcome of Renal Replacement Therapy in Patients with Congenital Malformations of the Kidney and Urinary Tract

Author

Wuhl, E., Stralen, K.J. van, Verrina, E., Bjerre, A., Wanner, C., Heaf, J.G., Zurriaga, O., Hoitsma, A.J., Niaudet, P., Palsson, R., Ravani, P., Jager, K.J., Schaefer, F., Wuhl, E., Stralen, K.J. van, Verrina, E., Bjerre, A., Wanner, C., Heaf, J.G., Zurriaga, O., Hoitsma, A.J., Niaudet, P., Palsson, R., Ravani, P., Jager, K.J., and Schaefer, F.

Abstract

Item does not contain fulltext, BACKGROUND AND OBJECTIVES: Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of ESRD in children, but the proportion of patients with individual CAKUT entities progressing to ESRD during adulthood and their long-term clinical outcomes are unknown. This study assessed the age at onset of renal replacement therapy (RRT) and patient and renal graft survival in patients with CAKUT across the entire age range. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients with CAKUT were compared with age-matched patients who were undergoing RRT for other renal disorders on the basis of data from the European Renal Association-European Dialysis and Transplant Association Registry. Competing risk and Cox regression analyses were conducted. RESULTS: Of 212,930 patients commencing RRT from 1990 to 2009, 4765 (2.2%) had renal diagnoses consistent with CAKUT. The proportion of incident RRT patients with CAKUT decreased from infancy to childhood and then increased until age 15-19 years, followed by a gradual decline throughout adulthood. Median age at RRT start was 31 years in the CAKUT cohort and 61 years in the non-CAKUT cohort (P<0.001). RRT was started earlier (median, 16 years) in patients with isolated renal dysplasia than in those with renal hypoplasia and associated urinary tract disorders (median, 29.5-39.5 years). Patients with CAKUT survived longer than age- and sex-matched non-CAKUT controls because of lower cardiovascular mortality (10-year survival rate, 76.4% versus 70.7%; P<0.001). CONCLUSIONS: CAKUT leads to ESRD more often at adult than pediatric age. Treatment outcomes differ from those of acquired kidney diseases and vary within CAKUT subcategories.

Published
2013

32. Outcomes of male patients with alport syndrome undergoing renal replacement therapy

Author

Temme, J., Kramer, A., Jager, K.J., Lange, K., Peters, F., Muller, G.A., Kramar, R., Heaf, J.G., Finne, P., Palsson, R., Reisaeter, A.V., Hoitsma, A.J., Metcalfe, W., Postorino, M., Zurriaga, O., Santos, J.P., Ravani, P., Jarraya, F., Verrina, E., Dekker, F.W., Gross, O., Temme, J., Kramer, A., Jager, K.J., Lange, K., Peters, F., Muller, G.A., Kramar, R., Heaf, J.G., Finne, P., Palsson, R., Reisaeter, A.V., Hoitsma, A.J., Metcalfe, W., Postorino, M., Zurriaga, O., Santos, J.P., Ravani, P., Jarraya, F., Verrina, E., Dekker, F.W., and Gross, O.

Abstract

Item does not contain fulltext, BACKGROUND AND OBJECTIVES: Patients with the hereditary disease Alport syndrome commonly require renal replacement therapy (RRT) in the second or third decade of life. This study compared age at onset of RRT, renal allograft, and patient survival in men with Alport syndrome receiving various forms of RRT (peritoneal dialysis, hemodialysis, or transplantation) with those of men with other renal diseases. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients with Alport syndrome receiving RRT identified from 14 registries in Europe were matched to patients with other renal diseases. A linear spline model was used to detect changes in the age at start of RRT over time. Kaplan-Meier method and Cox regression analysis were used to examine patient and graft survival. RESULTS: Age at start of RRT among patients with Alport syndrome remained stable during the 1990s but increased by 6 years between 2000-2004 and 2005-2009. Survival of patients with Alport syndrome requiring dialysis or transplantation did not change between 1990 and 2009. However, patients with Alport syndrome had better renal graft and patient survival than matched controls. Numbers of living-donor transplantations were lower in patients with Alport syndrome than in matched controls. CONCLUSIONS: These data suggest that kidney failure in patients with Alport syndrome is now being delayed compared with previous decades. These patients appear to have superior patient survival while undergoing dialysis and superior patient and graft survival after deceased-donor kidney transplantation compared with patients receiving RRT because of other causes of kidney failure.

Published
2012

33. Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.

Author

Gudbjartsson, D.F., Holm, H., Indridason, O.S., Thorleifsson, G., Edvardsson, V., Sulem, P., Vegt, F. de, D'Ancona, F.C.H., Heijer, M. den, Wetzels, J.F.M., Franzson, L., Rafnar, T., Kristjansson, K., Bjornsdottir, U.S., Eyjolfsson, G.I., Kiemeney, L.A.L.M., Kong, A., Palsson, R., Thorsteinsdottir, U., Stefansson, K., Gudbjartsson, D.F., Holm, H., Indridason, O.S., Thorleifsson, G., Edvardsson, V., Sulem, P., Vegt, F. de, D'Ancona, F.C.H., Heijer, M. den, Wetzels, J.F.M., Franzson, L., Rafnar, T., Kristjansson, K., Bjornsdottir, U.S., Eyjolfsson, G.I., Kiemeney, L.A.L.M., Kong, A., Palsson, R., Thorsteinsdottir, U., and Stefansson, K.

Abstract

Contains fulltext : 88375.pdf (publisher's version ) (Open Access), Chronic kidney disease (CKD) is a worldwide public health problem that is associated with substantial morbidity and mortality. To search for sequence variants that associate with CKD, we conducted a genome-wide association study (GWAS) that included a total of 3,203 Icelandic cases and 38,782 controls. We observed an association between CKD and a variant with 80% population frequency, rs4293393-T, positioned next to the UMOD gene (GeneID: 7369) on chromosome 16p12 (OR = 1.25, P = 4.1x10(-10)). This gene encodes uromodulin (Tamm-Horsfall protein), the most abundant protein in mammalian urine. The variant also associates significantly with serum creatinine concentration (SCr) in Icelandic subjects (N = 24,635, P = 1.3 x 10(-23)) but not in a smaller set of healthy Dutch controls (N = 1,819, P = 0.39). Our findings validate the association between the UMOD variant and both CKD and SCr recently discovered in a large GWAS. In the Icelandic dataset, we demonstrate that the effect on SCr increases substantially with both age (P = 3.0 x 10(-17)) and number of comorbid diseases (P = 0.008). The association with CKD is also stronger in the older age groups. These results suggest that the UMOD variant may influence the adaptation of the kidney to age-related risk factors of kidney disease such as hypertension and diabetes. The variant also associates with serum urea (P = 1.0 x 10(-6)), uric acid (P = 0.0064), and suggestively with gout. In contrast to CKD, the UMOD variant confers protection against kidney stones when studied in 3,617 Icelandic and Dutch kidney stone cases and 43,201 controls (OR = 0.88, P = 5.7 x 10(-5)).

Published
2010

34. Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density.

Author

Thorleifsson, G., Holm, H., Edvardsson, V., Walters, G.B., Styrkarsdottir, U., Gudbjartsson, D.F., Sulem, P., Halldorsson, B.V., Vegt, F. de, D'Ancona, F.C.H., Heijer, M. den, Franzson, L., Christiansen, C., Alexandersen, P., Rafnar, T., Kristjansson, K., Sigurdsson, G., Kiemeney, L.A.L.M., Bodvarsson, M., Indridason, O.S., Palsson, R., Kong, A., Thorsteinsdottir, U., Stefansson, K., Thorleifsson, G., Holm, H., Edvardsson, V., Walters, G.B., Styrkarsdottir, U., Gudbjartsson, D.F., Sulem, P., Halldorsson, B.V., Vegt, F. de, D'Ancona, F.C.H., Heijer, M. den, Franzson, L., Christiansen, C., Alexandersen, P., Rafnar, T., Kristjansson, K., Sigurdsson, G., Kiemeney, L.A.L.M., Bodvarsson, M., Indridason, O.S., Palsson, R., Kong, A., Thorsteinsdottir, U., and Stefansson, K.

Abstract

Contains fulltext : 81561.pdf (publisher's version ) (Closed access), Kidney stone disease is a common condition. To search for sequence variants conferring risk of kidney stones, we conducted a genome-wide association study in 3,773 cases and 42,510 controls from Iceland and The Netherlands. We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 x 10(-12) for rs219780[C]). Approximately 62% of the general population is homozygous for rs219780[C] and is estimated to have 1.64 times greater risk of developing the disease compared to noncarriers. The CLDN14 gene is expressed in the kidney and regulates paracellular permeability at epithelial tight junctions. The same variants were also found to associate with reduced bone mineral density at the hip (P = 0.00039) and spine (P = 0.0077).

Published
2009

35. U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery

Author

Metcalf, R G, primary, Skuladottir, G V, additional, Indridason, O S, additional, Sullivan, T R, additional, Bjorgvinsdottir, L, additional, Sanders, P, additional, Arnar, D O, additional, Gibson, R A, additional, Heidarsdottir, R, additional, Cleland, L G, additional, Palsson, R, additional, Farquharson, A L, additional, Young, G D, additional, and James, M J, additional

Published
2013
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38. Clinical Nephrology - Lab methods and other markers

Author

Kleophas, W., primary, Bieber, B., additional, Robinson, B., additional, Duttlinger, J., additional, Fliser, D., additional, Lonneman, G., additional, Rump, L., additional, Pisoni, R., additional, Port, F., additional, Reichel, H., additional, Daniela, R., additional, Ciocalteu, A., additional, Checherita, I. A., additional, Peride, I., additional, Spataru, D. M., additional, Niculae, A., additional, Laetitia, K., additional, Amna, K., additional, Laurence, D., additional, Aoumeur, H.-A., additional, Flamant, M., additional, Haymann, J.-P., additional, Letavernier, E., additional, Vidal-Petiot, E., additional, Boffa, J.-J., additional, Vrtovsnik, F., additional, Bianco, F., additional, Pessolano, G., additional, Carraro, M., additional, Panzetta, G. O., additional, Ebert, N., additional, Gaedeke, J., additional, Jakob, O., additional, Kuhlmann, M., additional, Martus, P., additional, Van der Giet, M., additional, Scha  ner, E., additional, Khan, I., additional, Law, Y., additional, Turgutalp, K., additional, Ozhan, O., additional, Gok Oguz, E., additional, Kiykim, A., additional, Donadio, C., additional, Hatmi, Z. N., additional, Mahdavi-Mazdeh, M., additional, Morales, E., additional, Gutierrez-Millet, V., additional, Rojas-Rivera, J., additional, Huerta, A., additional, Gutierrez, E., additional, Gutierrez-Solis, E., additional, Polanco, N., additional, Caro, J., additional, Gonza z, E., additional, Praga, M., additional, Marco Mayayo, M., additional, Valdivielso, J., additional, Marti  z, M., additional, Fernaez Giraez, E., additional, Obrador, G., additional, Olvera, N., additional, Ortiz de la Pe, D., additional, Gutie ez, V., additional, Villa, A., additional, Redal-Baigorri, B., additional, Sombolos, K., additional, Tsakiris, D., additional, Boletis, J., additional, Vlahakos, D., additional, Siamopoulos, K., additional, Vargiemezis, V., additional, Nikolaidis, P., additional, Iatrou, C., additional, Dafnis, E., additional, Argyropoulos, C., additional, Xynos, K., additional, Schock-Kusch, D., additional, Shulhevich, Y., additional, Geraci, S., additional, Hesser, J., additional, Stsepankou, D., additional, Neudecker, S., additional, Koenig, S., additional, Hoecklin, F., additional, Pill, J., additional, Gretz, N., additional, Schweda, F., additional, Schreiber, A., additional, Kudo, K., additional, Konta, T., additional, Choi, S. O., additional, Kim, J. S., additional, Kim, M. K., additional, Yang, J. W., additional, Han, B. G., additional, Delanaye, P., additional, Cavalier, E., additional, Masson, I., additional, Mehdi, M., additional, Nicolas, M., additional, Lambermont, B., additional, Dubois, B., additional, Damas, P., additional, Krzesinski, J.-M., additional, Morel, J., additional, Lautrette, A., additional, Christophe, M., additional, Gagneux-Brunon, A., additional, Anne, F., additional, Fre (C)ric, L., additional, Bevc, S., additional, Ekart, R., additional, Hojs, R., additional, Gorenjak, M., additional, Puklavec, L., additional, Hashimoto, N., additional, Suzuki, A., additional, Mitsumoto, K., additional, Shimizu, M., additional, Niihata, K., additional, Kawabata, A., additional, Sakaguchi, Y., additional, Hayashi, T., additional, Shoji, T., additional, Okada, N., additional, Tsubakihara, Y., additional, Hamano, T., additional, Nakano, C., additional, Fujii, N., additional, Obi, Y., additional, Mikami, S., additional, Inoue, K., additional, Matsui, I., additional, Isaka, Y., additional, Rakugi, H., additional, Edvardsson, V., additional, Siguron, B., additional, Thorsteinsdottir, M., additional, Palsson, R., additional, Matsumoto, J., additional, Miyazaki, N., additional, Murata, I., additional, Yoshida, G., additional, Morishita, K., additional, Ushikoshi, H., additional, Nishigaki, K., additional, Ogura, S., additional, Minatoguchi, S., additional, Werneke, U., additional, Ott, M., additional, Salander-Renberg, E., additional, Taylor, D., additional, Stegmayr, B., additional, Surel, S., additional, Wenzlova, M., additional, Silva Junior, G., additional, Vieira, A. P., additional, Couto Bem, A., additional, Alves, M., additional, Torres, A., additional, Meneses, G., additional, Martins, A., additional, Liborio, A., additional, Daher, E., additional, Gluhovschi, G., additional, Modilca, M., additional, Daminescu, L., additional, Gluhovschi, C., additional, Velciov, S., additional, Petrica, L., additional, Gadalean, F., additional, Balgradean, C., additional, Schmeiser, H. H., additional, Kolesnyk, M., additional, Stepanova, N., additional, Surzhko, L., additional, Stashevska, N., additional, Filiopoulos, V., additional, Hadjiyannakos, D., additional, Arvanitis, D., additional, Panagiotopoulos, K., additional, Vlassopoulos, D., additional, Kaesler, N., additional, Schettgen, T., additional, Magdeleyns, E., additional, Brandenburg, V., additional, Vermeer, C., additional, Floege, J., additional, Kr, T., additional, Randone, O., additional, Ferraresi, M., additional, Aroasio, E., additional, Depascale, A., additional, Scognamiglio, S., additional, Consiglio, V., additional, Piccoli, G. B., additional, Jensen, L. V., additional, Lizakowski, S., additional, Rutkowski, P., additional, Tylicki, L., additional, Renke, M., additional, Sulikowska, B., additional, Donderski, R., additional, Bednarski, R., additional, Heleniak, Z., additional, Przybylska, M., additional, Manitius, J., additional, Rutkowski, B., additional, Bobrova, L., additional, Kozlovskaya, N., additional, Kanayama, K., additional, Hasegawa, M., additional, Kitagawa, F., additional, Ishii, J., additional, Yuzawa, Y., additional, Tanaka, K., additional, Sakai, K., additional, Hara, S., additional, Suzuki, Y., additional, Tanaka, Y., additional, Aikawa, A., additional, Hinoshita, F., additional, Hamano, N., additional, Sasaki, E., additional, Kato, A., additional, Katsuki, T., additional, Katsuma, A., additional, Imai, E., additional, Shibata, M., additional, Tada, M., additional, Shimbo, T., additional, Kikuchi, Y., additional, Oka, S., additional, Muramatsu, T., additional, Yanagisawa, N., additional, Fukutake, K., additional, Yamamoto, Y., additional, Ajisawa, A., additional, Tsuchiya, K., additional, Nitta, K., additional, Ando, M., additional, Liang, X., additional, Wang, P., additional, Liu, Z., additional, Zhao, Z., additional, Luyckx, V., additional, Bowker, S., additional, Miekle, A., additional, Toth, E., additional, Heguilen, R., additional, Malvar, A., additional, Hermes, R., additional, Cohen, L., additional, Muguerza, G., additional, Lococo, B., additional, Bernasconi, A., additional, Loboda, O., additional, Dudar, I., additional, Krot, V., additional, Alekseeva, V., additional, Ichinose, M., additional, Sasagawa, N., additional, Toyama, K., additional, Saito, A., additional, Kayamori, Y., additional, Kang, D., additional, Kim, H. W., additional, Yoshioka, K., additional, Hara, M., additional, Ohashi, K., additional, Maksudova, A., additional, Khalfina, T., additional, Cuoghi, A., additional, Bellei, E., additional, Caiazzo, M., additional, Bergamini, S., additional, Palladino, G., additional, Monari, E., additional, Tomasi, A., additional, Loiacono, E., additional, Camilla, R., additional, Dapr, V., additional, Morando, L., additional, Gallo, R., additional, Peruzzi, L., additional, Conrieri, M., additional, Bianciotto, M., additional, Bosetti, F. M., additional, Coppo, R., additional, DI Lullo, L., additional, Floccari, F., additional, Rivera, R., additional, Granata, A., additional, Faiola, R., additional, Feliziani, C., additional, Villani, A., additional, Malaguti, M., additional, Santoboni, A., additional, Kyriaki, K., additional, Droulias, J., additional, Bogdanova, M., additional, Rameev, V. V., additional, Simonyan, A. H., additional, Kozlovskaya, L. V., additional, Altiparmak, M. R., additional, Trabulus, S., additional, Akalin, N., additional, Yalin, A. S., additional, Esenkaya, A., additional, Yalin, S. F., additional, Serdengeae(C), K., additional, Arita, D., additional, Cunha, T., additional, Perez, J., additional, Sakata, M., additional, Arita, L., additional, Nogueira, M., additional, Jara, Z., additional, Souza, N., additional, Casarini, D., additional, Metzger, M., additional, Vallet, M., additional, Karras, A., additional, Froissart, M., additional, Stengel, B., additional, Houillier, P., additional, Paul, K., additional, Kretzschmar, D., additional, Yilmaz, A., additional, Ba hlein, B., additional, Titze, S., additional, Figulla, H.-R., additional, Wolf, G., additional, Busch, M., additional, Korotchaeva, Y., additional, Gordovskaya, N., additional, Kozlovskaya, L., additional, Ng, K. P., additional, Sharma, P., additional, Stringer, S., additional, Jesky, M., additional, Dutton, M., additional, Ferro, C., additional, Cockwell, P., additional, Moon, S. J., additional, Lee, S. C., additional, Yoon, S. Y., additional, Lee, J. E., additional, Han, S. J., additional, Anna, B., additional, Kirsch, T., additional, Svjetlana, L., additional, Joon-Keun, P., additional, Jan, B., additional, Johanna, K., additional, Haller, H., additional, Haubitz, M., additional, Smirnov, A., additional, Kayukov, I., additional, Rafrafi, N., additional, Degtereva, O., additional, Dobronravov, V., additional, Koch, M., additional, Stefan, H., additional, Dika, G., additional, Antoine, M.-H., additional, Husson, C., additional, Kos, J., additional, Milic, M., additional, Fucek, M., additional, Cvoriocec, D., additional, Bourgeade, M.-F., additional, Nortier, J. L., additional, Jelakovic, B., additional, Nawal, E. H., additional, Naoufal, M., additional, Nabila, M., additional, Fadwa, E. M., additional, Salma, E. K., additional, Nisrine, B., additional, Mohamed, Z., additional, Guislaine, M., additional, Mohamed Gharbi, B., additional, Benyounes, R., additional, Sotila, G. G., additional, Sorin, R., additional, Irina Magdalena, D., additional, Roxana, C., additional, Claudia, R., additional, Correa Barcellos, F., additional, Hallal, P. H., additional, Bohlke, M., additional, Boscolo Del Vechio, F., additional, Reges, A., additional, Santos, I., additional, Mielke, G., additional, Fortes, M., additional, Antunez, B., additional, Laganovic, M., additional, Vukovic Lela, I., additional, Karanovic, S., additional, Seric, J., additional, Premuic, V., additional, Fitrek, M., additional, Fodor, L., additional, Meljkovic Vrkic, T., additional, Bansal, V., additional, Hoppensteadt, D., additional, and Fareed, J., additional

Published
2012
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39. Mineral homeostasis and nephrolithiasis

Author

Letavernier, E., primary, Letavernier, E., additional, Rodenas, A., additional, Guerrot, D., additional, Haymann, J.-P., additional, Quaglia, M., additional, Merlotti, G., additional, Fenoglio, R., additional, Menegotto, A., additional, Izzo, C., additional, Airoldi, A., additional, Guarnieri, V., additional, Stratta, P., additional, Edvardsson, V., additional, Haroarson, S., additional, Palsson, R., additional, Thorens, B., additional, Muriel, A., additional, Olivier, B., additional, Froeder, L., additional, Calabria Baxmann, A., additional, and Pfeferman Heilberg, I., additional

Published
2012
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40. Senescence rates in patients with end-stage renal disease: a critical appraisal of the Gompertz model

Author

Koopman, J. J. E., primary, Rozing, M. P., additional, Kramer, A., additional, de Jager, D. J., additional, Ansell, D., additional, De Meester, J. M. J., additional, Prütz, K. G., additional, Finne, P., additional, Heaf, J. G., additional, Palsson, R., additional, Kramar, R., additional, Jager, K. J., additional, Dekker, F. W., additional, and Westendorp, R. G. J., additional

Published
2010
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44. Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation.

Author

Skuladottir, G. V., Cohen, A., Arnar, D. O., Hougaard, D. M., Torfason, B., Palsson, R., and Indridason, O. S.

Abstract

Low circulating levels of total 25-hydroxyvitamin D (25(OH)D) have been associated with an increased risk of adverse effects after cardiac surgery. The metabolites, 25(OH)D2 and 25(OH)D3, provide a good index of vitamin D status. In this study, we examined the association between preoperative plasma levels of total 25(OH)D, 25(OH)D2 and 25(OH)D3 and the risk of postoperative atrial fibrillation (POAF) following open heart surgery. The levels of plasma 25(OH)D2 and 25(OH)D3 in 118 patients, who underwent coronary artery bypass grafting and/or valvular surgery, were measured immediately prior to surgery and on postoperative day 3 by liquid chromatography-tandem mass spectrometry. Patients who developed POAF had higher median plasma levels of 25(OH)D2 than those who remained in sinus rhythm (SR) (P = 0·003), but no significant difference was noted in levels of 25(OH)D3 or total 25(OH)D between the two groups (P > 0·05). By univariate analysis, patients with total 25(OH)D and 25(OH)D2 levels above the median had higher frequency of POAF (P < 0·05) and the incidence of POAF increased significantly with each higher quartile of preoperative plasma levels of 25(OH)D2 (P = 0·001), an association that was independent of confounding factors. In both the SR and POAF groups, the median plasma levels of 25(OH)D2, 25(OH)D3 and total 25(OH)D were lower (P < 0·05) on the third postoperative day compared with preoperatively. Our findings demonstrate that higher plasma levels of 25(OH)D2 are associated with increased risk of POAF, while this is not the case for 25(OH)D3 or total 25(OH)D. The reason for these discrepant results is not clear but warrants further study. [ABSTRACT FROM AUTHOR]

Published
2016
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48. Gender Disparities in Access to Pediatric Renal Transplantation in Europe: Data From the ESPN/ERA‐EDTA Registry

Author

Hogan, J., Couchoud, C., Bonthuis, M., Groothoff, J. W., Jager, K. J., Schaefer, F., Van Stralen, K. J., Shitza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., Hoeck, K., Collart, F., Grottes, J. M., Pokrajac, D., Resić, H., Prnjavorac, B., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J. G., Toots, U., Finne, P., Grönhagen‐Riska, C., Lasalle, M., Sahpazova, E., Gersdorf, G., Barth, C., Scholz, C., Tönshoff, B., Ioannidis, G., Kapogiannis, A., Papachristou, F., Reusz, G., Túri, S., Szabó, L., Szabó, T., Györke, Z. S., Kis, E., Palsson, R., Edvardsson, V., Gianoglio, B., Palo, T., Pecoraro, C., Picca, S., Testa, S., Vidal, E., Mencarelli, F., Jankauskiene, A., Pundziene, B., Said‐Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Bjerre, A., Zurowska, A., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Podgoreanu, E., Molchanova, E. A., Tomilina, N. A., Bikbov, B. T., Kostic, M., Peco‐Antic, A., Puric, S., Kruscic, D., Spasojevic‐Dimitrijeva, B., Milosecski‐Lomic, G., Paripovic, D., Podracka, L., Kolvek, G., Buturovic‐Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K. G., Seeberger, A., Backmän, L., Evans, M., Kuenhi, C. E., Maurer, E., Laube, G., Simometi, G., Hoitsma, A., Hemke, A., Topaloglu, R., Duzova, A., Ivanov, D., and Sinha, M.

Abstract

Inequalities between genders in access to transplantation have been demonstrated. We aimed to validate this gender inequality in a large pediatric population and to investigate its causes. This cohort study included 6454 patients starting renal replacement therapy before 18 years old, in 35 countries participating in the European Society for Paediatric Nephrology/European Renal Association–European Dialysis and Transplant Association Registry. We used cumulative incidence competing risk and proportional hazards frailty models to study the time to receive a transplant and hierarchical logistic regression to investigate access to preemptive transplantation. Girls had a slower access to renal transplantation because of a 23% lower probability of receiving preemptive transplantation. We found a longer follow‐up time before renal replacement therapy in boys compared with girls despite a similar estimated glomerular filtration rate at first appointment. Girls tend to progress faster toward end‐stage renal disease than boys, which may contribute to a shorter time available for pretransplantation workup. Overall, medical factors explained only 70% of the gender difference. In Europe, girls have less access to preemptive transplantation for reasons that are only partially related to medical factors. Nonmedical factors such as patient motivation and parent and physician attitudes toward transplantation and organ donation may contribute to this inequality. Our study should raise awareness for the management of girls with renal diseases. This large European study finds an association between female gender and a delay in access to renal transplantation in children, explained by a lower rate of pre‐emptive transplantation in girls, and explores other potential explanations for this gender inequality.

Published
2016
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49. Iceland poisoning study--preliminary results

Author

Snook, CP, Gudjonsdottir, GA, Kristinsson, J, Blondal, M, Palsson, R, and Gudmundsson, G

Subjects
Poisoning -- Demographic aspects, Poison control centers -- Usage, Emergency medical services -- Utilization, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Abstract

Background: A study was undertaken to assess the occurrence and nature of toxic exposures as well as the manner of response of the health care system to these events for an entire nation for one year. The nation in question is a small, physically isolated European country. Towards this end, a study was designed to obtain information about all exposure advice calls handled by health care facilities, and all patient visits to hospitals and health care facilities due to exposure to toxic substances. In this manner, the poison center could also gain a measure of its penetrance as an information source for such exposures in the country. Methods: The study was performed prospectively with a designated coordinator for each hospital and health care facility. Information was collected on a data sheet designed for ease of use and to allow comparison of the study data to data collected during the same period by the country's only poison information center. Inservice teaching was carried out to aid in correct collection of the data. Copies of the data sheet were sent along with written material describing the study and proper completion of the forms to the coordinators at all hospitals and health care centers in the country. The data sheet was to be filled out each time a phone call was received or a visit to a health care facility or hospital was made regarding exposure to a toxic substance. The study was carried out from April 1st, 2001, until March 31st, 2002. The completed data sheets were mailed to the study nurse at the largest hospital in the country to be collected and entered into a computer database. Results: Results are available at this time for the first 6 months of the study. 531 exposures to toxic substances were recorded of which 234 (44%) were exposures to pharmaceuticals, 208 (39%) non-pharmaceutical substances and 89 (17%) involved multiple agents. Exposures in children 6 years and younger represented 26% of the study sheets. Comparison to poison center data for the same period indicates that a majority of phone inquiries in this age group were made there. Among the most common causes of toxic substance exposure were suicide attempt--36%, accidental--25%, misuse of a substances for a purpose other that that intended--21%, occupational exposure--10% and other causes--8%. Again, this was in contrast to the poison center data for the same period for which the majority of exposures were accidental. Conclusions: Our preliminary data indicates that for the country as a whole, poisoning exposure has nearly the same incidence as motor vehicle accidents on a per capita basis, that poison exposures with symptoms occur as frequently as motor vehicle accidents with trauma, and that toxic exposures are much more common than previously believed. This data demonstrates poisoning exposure to be a grossly underestimated cause of illness and utilization of health care resources in this small, European country., Snook CP, Gudjonsdottir GA, Kristinsson J, Blondal M, Palsson R, Gudmundsson G. Iceland Poison Information Centre, University of Iceland, Surgeon General's Office, Dept. of Medicine, Landspitali University [...]

Published
2002

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