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124 results on '"Palone F"'

12. Low Dose of Dipotassium Glycyrrhizate Counteracts Atherosclerosis Progression in Apoe-/- Female Mice

Author

Palone, F., Pasquali, E., Giardullo, P., Stronati, L., Vitali, R., and Mancuso, M.

Subjects
Animal, Mice, Knockout, ApoE, Thoracic, Knockout, Aortic Diseases, Aorta, Thoracic, Atherosclerosis, Glycyrrhizic Acid, Lipids, Plaque, Atherosclerotic, Animals, Disease Models, Animal, Disease Progression, Female, HMGB1 Protein, Inflammation Mediators, Sex Factors, Mice, Disease Models, Aorta, ApoE, Plaque, Atherosclerotic
Published
2019

14. A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Author

De Luca, A, Parker, LJ, Ang, WH, Rodolfo, C, Gabbarini, V, Hancock, NC, Palone, F, Mazzetti, AP, Menin, L, Morton, CJ, Parker, MW, Lo Bello, M, Dyson, PJ, De Luca, A, Parker, LJ, Ang, WH, Rodolfo, C, Gabbarini, V, Hancock, NC, Palone, F, Mazzetti, AP, Menin, L, Morton, CJ, Parker, MW, Lo Bello, M, and Dyson, PJ

Abstract

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we probed the role of glutathione transferase (GST) P1-1, an antiapoptotic protein often overexpressed in drug-resistant tumors, as a cis-DDP-binding protein. Our results show that cis-DDP is not a substrate for the glutathione (GSH) transferase activity of GST P1-1. Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity. Furthermore, it is well known that GST P1-1 binding to the c-Jun N-terminal kinase (JNK) inhibits JNK phosphorylation, which is required for downstream apoptosis signaling. Thus, in turn, GST P1-1 overexpression and Pt-induced subunit cross-linking could modulate JNK apoptotic signaling, further confirming the role of GST P1-1 as an antiapoptotic protein.

Published
2019

17. Analysis of the plant and operational requirements for the design of a flexible and new generation LCC HVDC system: the Sa.Co.I 3 technology case

Author

Battaglia, A., primary, Buono, L., additional, De Zan, R., additional, Di Bartolomeo, E., additional, Marzinotto, M., additional, Palone, F., additional, Pazienza, M., additional, Pede, F., additional, Michi, L., additional, Carlini, E.M., additional, Scirocco, T. Baffa, additional, Bruno, G., additional, Gnudi, R., additional, Pecoraro, G., additional, and Pisani, C., additional

Published
2019
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33. Frequency domain studies for the Malta-Sicily interconnector

Author

Palone, F., Rebolini, M., Lauria, Stefano, Schembari, Maddalena, and Vassallo, J.

Subjects
switching transients, ac cables, frequency scan, harmonic resonance, switching transients, harmonic resonance, ac cables, frequency scan
Published
2014

42. Power System Technical Performance Issues Related to the Application of Long HVAC Cables

Author

Wiechowski, W., Ohno, T., Emin, Z., Mcdermott, T., Wilson, P., Akhmatov, V., Ametani, A., Bak, C. L., Benato, Roberto, Colla, L., Dorison, E., Dubois, D., Val Escudero, M., Fernandez, F., Golé, A. M., Gudmundsdottir, U. S., Henry, S., de Jong, J., Kessel, J., Lauria, S., Lerch, E., Lesur, F., Marti, L., Palone, F., Popov, M., Faria da Silva, F., de Silva, J., Van der Sluis, L., Sollerkvist, F. J., and Thorburn, S.

Published
2013

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