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1. Characteristics of the colorectal cancers diagnosed in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening [Caratteristiche dei tumori del colon retto diagnosticati in Italia nei primi anni Duemila. Dati dello studio IMPATTO sdelo screening colorettale]

Author

Zorzi, Manuel, Mangone, Lucia, Anghinoni, Emanuela, Baracco, Susanna, Borciani, Elisabetta, Caldarella, Adele, Falcini, Fabio, Fanetti, Anna Clara, Ferretti, Stefano, Rossi, Paolo Giorgi, Michiara, Maria, Randi, Giorgia, Stracci, Fabrizio, Vicentini, Massimo, Zucchetto, Antonella, Zappa, Marco, Giacomin, A., Azzoni, A., Baldazzi, P., Collina, N., Pandolfi, P., Biavati, P., Gualandi, G., Sciacca, S., Pesce, P., Torrisi, A., Sciacchitano, C., Fidelbo, M., Finarelli, A. C., Naldoni, C., De'Bianchi, P. Sassoli, Landi, P., Matarese, V., De Togni, A., Palmonari, C., Crocetti, E., Grazzini, G., Manneschi, G., Mantellini, P., Serraino, D., Bidoli, E., Taborelli, M., Gini, A., Virdone, S., Puppo, A., Casella, C., Celesia, M., Cogno, R., Marani, E., Bugliarello, E., Fattoruso, S., Tamburo, L., Tamburrino, S., Bellardini, P., Autelitano, M., Frammartino, B., Bisanti, L., Ghilardi, S., Leone, R., Corradini, R., De Girolamo, F., Valla, K., Palombino, R., Gigli, L., Spena, S. Russo, Vitale, M. F., Cascio, M. A., Mannino, R., Mazzucco, W., Mistretta, A., Ravazzolo, B., Sgarzi, P., Bozzani, F., Zatelli, M., Zurlini, C., Caruana, P., Seghini, P., Gatti, G., Prazzoli, R., Campari, C., Paterlini, L., Cassetti, T., Sassatelli, R., Imolesi, C., Casale, C., Serafini, M., Vattiato, R., Giuliani, O., Cesaraccio, R., Sechi, O., Budroni, M., Madeddu, A., Contrino, M. L., Ziino, A. Colanino, Russo, M., Tisano, F., Fanetti, A. C., Maspero, S., Moroni, E., Cometti, I., Gentilini, M., Piffer, S., De Pretis, G., Caciagli, P., Pertile, R., Bianconi, F., Bucchi, D., Galeotti, M. E., Malaspina, M., Greco, A., Fiore, A. R., Stocco, C. F., and Fedato, C.

Subjects
Colorectal cancer, Colorectal cancer screening, Italy, Epidemiology, Public Health, Environmental and Occupational Health, Environmental and Occupational Health, Socio-culturale, Public Health
Published
2015

3. I tumori in provincia di Napoli 1997-2002

Author

FUSCO, M, BIDOLI, E, DE CAMPORA, E, PALOMBINO, R, PEDICINI, T, PIZZUTI, R., CHIODINI, Paolo, Fusco, M, Bidoli, E, Chiodini, Paolo, DE CAMPORA, E, Palombino, R, Pedicini, T, and Pizzuti, R.

Published
2006

5. Sorveglianza e prevenzione delle malattie infettive e diffusive

Author

GIGLI L, PALOMBINO R, SPENA RUSSO S, TRIASSI, MARIA, Gigli, L, Palombino, R, SPENA RUSSO, S, and Triassi, Maria

Subjects
Sorveglianza Malattie Infettive
Abstract

Descrive le modalità di sorveglianza e prevenzione delle malattie infettive

Published
2005

6. Late presenters among persons with a new HIV diagnosis in Italy, 2010–2011

Author

Camoni, L., Raimondo, M., Regine, V., Salfa, M. C., Suligoi, B., Carboni, A, Cassiani, R, Chironna, M, Dardanoni, G, Finarelli, Ac, Gallo, L, Icardi, G, Locuratolo, F, Mura, Ms, Palombino, R, Gramegna, M, Pasqualini, C, Pristerà, R, Pozza, F, Rossetti, G, Scola, N, Sudano, L, Tosti, A, Voller, F, and Zaccone, A.

Subjects
Adult, Male, Gerontology, medicine.medical_specialty, Delayed Diagnosis, Epidemiology, Sexual Behavior, HIV diagnosis, Human immunodeficiency virus (HIV), Emigrants and Immigrants, HIV Infections, Disease, medicine.disease_cause, Statistics, Nonparametric, Risk-Taking, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Late presenters, Humans, Nonparametric, Substance Abuse, Intravenous, Surveillance, business.industry, Public health, Statistics, Substance Abuse, Public Health, Environmental and Occupational Health, HIV, Middle Aged, medicine.disease, CD4 Lymphocyte Count, Sexual Partners, Italy, Population Surveillance, Female, Biostatistics, Intravenous, business, Research Article
Abstract

Background In Western Europe, about 50% of newly diagnosed HIV-positive individuals are diagnosed at a late stage disease and enter in care late (i.e. with a CD4 count ≤350 μL/μL). The aim of the present study is to analyze the characteristics and the factors associated with being diagnosed late or at an advanced stage of disease among persons with a new HIV diagnosis in Italy, in the period 2010–2011. Methods We used individual data on new HIV diagnoses reported by the HIV surveillance system in 2010 and in 2011. Persons with CD4 ≤350 cells/μL or diagnosed with AIDS (regardless of the CD4 cell count) were defined as late presenters (LP); persons with CD4 ≤ 200 cells/μL or AIDS (regardless of the CD4 cell count) were defined as presenting with advanced HIV disease (AHD). Results Of the 7,300 new diagnoses reported in 2010–2011 by the included regions, 55.2% were LP; among these, 37.9% was diagnosed with AIDS. Persons presenting with AHD were 37.8%. The median age of LP was 40 years (IQR 33–48), significantly higher (p

Published
2013
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7. Cancer incidence in people with AIDS in Italy

Author

Polesel, J, Franceschi, S, Suligoi, B, Crocetti, E, Falcini, F, Guzzinati, S, Vercelli, M, Zanetti, R, Tagliabue, G, Russo, A, Luminari, S, Stracci, F, De Lisi, V, Ferretti, Stefano, Mangone, L, Budroni, M, Limina, Rm, Piffer, S, Serraino, D, Bellù, F, Giacomin, A, Donato, A, Madeddu, A, Vitarelli, S, Fusco, M, Tessandori, R, Tumino, R, Piselli, P, Dal Maso, L, Cancer, AIDS Registries Linkage Study Cancer, AIDS Registries Linkage Study, Lise, M, Zucchetto, A, De Paoli, A, Intrieri, T, Vattiato, R, Zambon, P, Puppo, A, Patriarca, S, Tittarelli, A, Autelitano, M, Cirilli, C, La Rosa, F, Sgargi, P, Di Felice, E, Cesaraccio, R, Donato, F, Franchini, S, Zanier, L, Vittadello, F, Vercellino, Pc, Senatore, G, Contrino, Ml, Antonini, S, Palombino, R, Maspero, S, La Rosa MG, Camoni, L, and Regine, V.

Subjects
AIDS, HAART, cancer incidence, lung cancer, liver cancer
Published
2010

8. STUDIO DI PREVALENZA DELL’INFEZIONE DA HCV E HBV IN UN’AREA DELLA CAMPANIA AD ELEVATA INCIDENZA DI EPATOCARCINOMA. RISULTATI PRELIMINARI

Author

Pisanti, F.A., primary, Quatrano, P., additional, Piselli, P., additional, Maione, C., additional, Fusco, M., additional, Palombino, R., additional, Girardi, E., additional, Scognamiglio, P., additional, Barzoni Secchia, S., additional, Bellelli, S., additional, Polesel, J., additional, Solmone, M.C., additional, Capobianchi, M., additional, Ippolito, G., additional, and Serraino, D., additional

Published
2006
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10. Characteristics of the colorectal cancers diagnosed in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening

Author

Zorzi, M., Lucia Mangone, Anghinoni, E., Baracco, S., Borciani, E., Caldarella, A., Falcini, F., Fanetti, A. C., Ferretti, S., Rossi, P. G., Michiara, M., Randi, G., Stracci, F., Vicentini, M., Zucchetto, A., Zappa, M., Giacomin, A., Azzoni, A., Baldazzi, P., Collina, N., Pandolfi, P., Biavati, P., Gualandi, G., Sciacca, S., Pesce, P., Torrisi, A., Sciacchitano, C., Fidelbo, M., Finarelli, A. C., Naldoni, C., Bianchi, P. S., Landi, P., Matarese, V., Togni, A., Palmonari, C., Crocetti, E., Grazzini, G., Manneschi, G., Mantellini, P., Serraino, D., Bidoli, E., Taborelli, M., Gini, A., Virdone, S., Puppo, A., Casella, C., Celesia, M., Cogno, R., Marani, E., Bugliarello, E., Fattoruso, S., Tamburo, L., Tamburrino, S., Bellardini, P., Autelitano, M., Frammartino, B., Bisanti, L., Ghilardi, S., Leone, R., Corradini, R., Girolamo, F., Valla, K., Palombino, R., Gigli, L., Spena, S. R., Vitale, M. F., Cascio, M. A., Mannino, R., Mazzucco, W., Mistretta, A., Ravazzolo, B., Sgarzi, P., Bozzani, F., Zatelli, M., Zurlini, C., Caruana, P., Seghini, P., Gatti, G., Prazzoli, R., Campari, C., Paterlini, L., Cassetti, T., Sassatelli, R., Imolesi, C., Casale, C., Serafini, M., Vattiato, R., Giuliani, O., Cesaraccio, R., Sechi, O., Budroni, M., Madeddu, A., Contrino, M. L., Ziino, A. C., Russo, M., Tisano, F., Maspero, S., Moroni, E., Cometti, I., Gentilini, M., Piffer, S., Pretis, G., Caciagli, P., Pertile, R., Bianconi, F., Bucchi, D., Galeotti, M. E., Malaspina, M., Greco, A., Fiore, A. R., Stocco, C. F., Fedato, C., Zorzi, M., Mangone, L., Anghinoni, E., Baracco, S., Borciani, E., Caldarella, A., Falcini, F., Fanetti, A., Ferretti, S., Rossi, P., Michiara, M., Randi, G., Stracci, F., Vicentini, M., Zucchetto, A., Zappa, M., Giacomin, A., Azzoni, A., Baldazzi, P., Collina, N., Pandolfi, P., Biavati, P., Gualandi, G., Sciacca, S., Pesce, P., Torrisi, A., Sciacchitano, C., Fidelbo, M., Finarelli, A., Naldoni, C., De'Bianchi, P., Landi, P., Matarese, V., De Togni, A., Palmonari, C., Crocetti, E., Grazzini, G., Manneschi, G., Mantellini, P., Serraino, D., Bidoli, E., Taborelli, M., Gini, A., Virdone, S., Puppo, A., Casella, C., Celesia, M., Cogno, R., Marani, E., Bugliarello, E., Fattoruso, S., Tamburo, L., Tamburrino, S., Bellardini, P., Autelitano, M., Frammartino, B., Bisanti, L., Ghilardi, S., Leone, R., Corradini, R., De Girolamo, F., Valla, K., Palombino, R., Gigli, L., Spena, S., Vitale, M., Cascio, M., Mannino, R., Mazzucco, W., Mistretta, A., Ravazzolo, B., Sgarzi, P., Bozzani, F., Zatelli, M., Zurlini, C., Caruana, P., Seghini, P., Gatti, G., Prazzoli, R., Campari, C., Paterlini, L., Cassetti, T., Sassatelli, R., Imolesi, C., Casale, C., Serafini, M., Vattiato, R., Giuliani, O., Cesaraccio, R., Sechi, O., Budroni, M., Madeddu, A., Contrino, M., Ziino, A., Russo, M., Tisano, F., Maspero, S., Moroni, E., Cometti, I., Gentilini, M., Piffer, S., De Pretis, G., Caciagli, P., Pertile, R., Bianconi, F., Bucchi, D., Galeotti, M., Malaspina, M., Greco, A., Fiore, A., Stocco, C., and Fedato, C.

Subjects
Colorectal cancer, Colorectal cancer screening, Italy, Epidemiology, Public Health, Environmental and Occupational Health, Settore MED/42 - Igiene Generale E Applicata
Abstract

The impact of organized screening programmes on colorectal cancer (CRC) can be observed at a population level only several years after the implementation of screening. We compared CRC characteristics by diagnostic modality (screen-detected, non-screen-detected) as an early outcome to monitor screening programme effectiveness. Data on CRCs diagnosed in Italy from 2000 to 2008 were collected by several cancer registries. Linkage with screening datasets made it possible to divide the cases by geographic area, implementation of screening, and modality of diagnosis (screen-detected, non-screen-detected).We compared the main characteristics of the different subgroups of CRCs through multivariate logistic regression models. The study included 23,668 CRCs diagnosed in subjects aged 50-69 years, of which 11.9%were screendetected (N=2,806), all from the North-Centre of Italy. Among screen-detected CRCs, we observed a higher proportion of males, of cases in the distal colon, and a higher mean age of the patients. Compared with pre-screening cases, screen-detected CRCs showed a better distribution by stage at diagnosis (OR for stage III or IV: 0.40, 95%CI: 0.36-0.44) and grading (OR for poorly differentiated CRCs was 0.86, 95%CI: 0.75-1.00). Screen-detected CRCs have more favourable prognostic characteristics than non-screen-detected cases. A renewed effort to implement screening programmes throughout the entire country is recommended.

11. Incidence trends of colorectal cancer in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening

Author

Zorzi, M., Mangone, L., Sassatelli, R., Baracco, S., Budroni, M., Castaing, M., Cirilli, C., Cusimano, R., Fusco, M., Giacomin, A., Rossi, P. G., Naldoni, C., Pannozzo, F., Piffer, S., Puppo, A., Tisano, F., Zappa, M., Azzoni, A., Baldazzi, P., Collina, N., Pandolfi, P., Petrucci, C., Gualandi, G., Sciacchitano, S., Ieni, A., Bella, F., Torrisi, A., Varvarà, M., Finarelli, A. C., Bianchi, P. S., Landi, P., Ferretti, S., Matarese, V., Togni, A., Palmonari, C., Caldarella, A., Crocetti, E., Grazzini, G., Manneschi, G., Mantellini, P., Serraino, D., Bidoli, E., Taborelli, M., Gini, A., Virdone, S., Casella, C., Celesia, M., Cogno, R., Marani, E., Busco, S., Bernazza, E., Curatella, S., Macci, L., Rossi, M., Randi, G., Frammartino, B., Bonini, A., Filippazzi, L., Giubelli, C., Corradini, R., Girolamo, F., Valla, K., Palombino, R., D Orsi, M., Isernia, M., Vitale, F. M., Adamo, M. S., Amodio, R., Brucculeri, A., Guttadauro, A., WALTER MAZZUCCO, Sgarzi, P., Bozzani, F., Zatelli, M., Zurlini, C., Caruana, P., Borciani, E., Gatti, G., Prazzoli, R., Seghini, P., Campari, C., Di Felice, E., Sacchettini, C., Cassetti, T., Falcini, F., Mancini, S., Vattiato, R., Giuliani, O., Caprara, L., Cesaraccio, R., Sechi, O., Madeddu, A., Contrino, M. L., Colanino Ziino, A., Russo, M., Fanetti, A. C., Maspero, S., Moroni, E., Cometti, I., Gentilini, M., Pretis, G., Caciagli, P., Pertile, R., Bianconi, F., Masanotti, G. M., Lio, M. C., Leite, S., Passamonti, B. U., Dei Tos, A. P., Rosano, A., Monetti, D., Guzzinati, S., Tognazzo, S., Zorzi, M., Mangone, L., Sassatelli, R., Baracco, S., Budroni, M., Castaing, M., Cirilli, C., Cusimano, R., Fusco, M., Giacomin, A., Rossi, P., Naldoni, C., Pannozzo, F., Piffer, S., Puppo, A., Tisano, F., Zappa, M., Azzoni, A., Baldazzi, P., Collina, N., Pandolfi, P., Petrucci, C., Gualandi, G., Sciacchitano, S., Ieni, A., Bella, F., Torrisi, A., Varvarã , M., Finarelli, A., De Bianchi, P., Landi, P., Ferretti, S., Matarese, V., De Togni, A., Palmonari, C., Caldarella, A., Crocetti, E., Grazzini, G., Manneschi, G., Mantellini, P., Serraino, D., Bidoli, E., Taborelli, M., Gini, A., Virdone, S., Casella, C., Celesia, M., Cogno, R., Marani, E., Busco, S., Bernazza, E., Curatella, S., Macci, L., Rossi, M., Randi, G., Frammartino, B., Bonini, A., Filippazzi, L., Giubelli, C., Corradini, R., De Girolamo, F., Valla, K., Palombino, R., D'Orsi, M., Isernia, M., Fusco, E., Vitale, F., Adamo, M., Amodio, R., Brucculeri, A., Guttadauro, A., Mazzucco, W., Sgarzi, P., Bozzani, F., Zatelli, M., Zurlini, C., Caruana, P., Borciani, E., Gatti, G., Prazzoli, R., Seghini, P., Campari, C., Di Felice, E., Sacchettini, C., Cassetti, T., Falcini, F., Mancini, S., Vattiato, R., Giuliani, O., Caprara, L., Cesaraccio, R., Sechi, O., Madeddu, A., Contrino, M., Colanino Ziino, A., Russo, M., Fanetti, A., Maspero, S., Moroni, E., Cometti, I., Gentilini, M., De Pretis, G., Caciagli, P., Pertile, R., Bianconi, F., Masanotti, G., De Lio, M., Leite, S., Passamonti, B., Dei Tos, A., Rosano, A., Monetti, D., Guzzinati, S., and Tognazzo, S.

Subjects
Colorectal cancer, Fecal immunochemical test, Incidence rates, Italy, Screening, Epidemiology, Public Health, Environmental and Occupational Health, Environmental and Occupational Health, Socio-culturale, Public Health, Incidence rate, Settore MED/42 - Igiene Generale E Applicata
Abstract

We utilised the IMPATTO study's archives to describe the 2000-2008 colorectal cancer (CRC) incidence rate trends in Italy, once screening programmes based on the faecal immunochemical test were implemented in different areas. Data on CRCs diagnosed in Italy from 2000 to 2008 in subjects aged 40-79 years were collected by 23 cancer registries. Incidence rate trends were evaluated as a whole and by macro-area (North-Centre and South-Islands), presence of a screening programme, sex, ten-year age class, anatomic site, stage at diagnosis, and pattern of diagnosis (screen-detected, non-screen-detected). The annual percent change (APC) of incidence rate trends, with 95% confidence intervals (95%CI), were computed. The study included 46,857 CRCs diagnosed in subjects aged 40-79 years, of which 2,806 were screendetected. The incidence rates in the North-Centre were higher than in the South and on the Islands. During the study period, screening programmes had been implemented only in the North-Centre and had a significant effect on incidence rates, with an initial sharp increase in incidence, followed by a decrease that started in the 3rd-4th years of screening. These incidence rate trends were exclusively due to modifications in the rates of stage I cases. After screening programmes started, incidence increased in all anatomic sites, particularly in the distal colon. The differential figures introduced by the implementation of screening programmes warrant a continuous surveillance of CRC incidence and mortality trends to monitor the impact of screening at a national level.

12. Provisional Measures in ICSID Arbitration Proceedings: Between the Current Legal Framework and the Proposed Reform

Author

Domenico Pauciulo, F.M. Palombino, R. Virzo, G. Zarra, and Pauciulo, Domenico

Subjects
arbitral proceedings, conservatory measures, public international law, Proportionality (law), Context (language use), Provisional measures, investment law, urgency, Public international law, Political science, Interim, Investment Arbitration, ICSID, Provisional measures, Procedural law, ISDS, arbitral tribunal, investment law, international law, public international law, conservatory measures, proportionality, necessity, urgency, arbitral proceedings, Procedural law, international law, Law and economics, International court, proportionality, arbitral tribunal, International law, necessity, ISDS, Arbitration, Investment Arbitration, ICSID, Provisional measures, Procedural law, ISDS, arbitral tribunal, investment law, international law, public international law, conservatory measures, proportionality, necessity, urgency, arbitral proceedings, diritto internazionale, diritto internazionale degli investimenti, investimenti esteri, economia, misure cautelari, ICSID
Abstract

Provisional measures have an enormous importance in the context of investment arbitration given the continuous recourse to interim protection by disputing parties. While the letter of Article 47 ICSID Convention and Arbitration Rule No. 39 is silent on the necessary requirements for the adoption of provisional measures and on the legal nature of provisional orders, ICSID tribunals have adopted a significant number of decisions which seems to clarify the effective limits of ICSID arbitral tribunals’ precautionary powers and a plain influence of the International Court of Justice’s jurisprudence on provisional protection of rights. This chapter therefore addresses procedural and substantial issues regarding the adoption of provisional measures by ICSID arbitrators, also identifying typical interim orders—through the analysis of the arbitral practice—and the possible consequence in case of non-compliance by the opposing party. Lastly, in consideration of the ongoing amendment process of the ICSID Rules, this chapter proposes a scrutiny of the anticipated reform of ICSID rules on provisional measures.

Published
2021

15. Priority persistent contaminants in people dwelling in critical areas of Campania Region, Italy (SEBIOREC biomonitoring study).

Author

De Felip E, Bianchi F, Bove C, Cori L, D'Argenzio A, D'Orsi G, Fusco M, Miniero R, Ortolani R, Palombino R, Parlato A, Pelliccia MG, Peluso F, Piscopo G, Pizzuti R, Porpora MG, Protano D, Senofonte O, Spena SR, Simonetti A, and di Domenico A

Subjects
Adult, Dioxins metabolism, Environmental Monitoring, Female, Halogenated Diphenyl Ethers metabolism, Humans, Italy, Male, Middle Aged, Polychlorinated Biphenyls metabolism, Risk Assessment, Young Adult, Environmental Exposure statistics & numerical data, Environmental Pollutants metabolism
Abstract

To investigate if protracted living in degraded environments of the Caserta and Naples provinces (Campania Region, Italy) had an impact on exposure of local people, highly toxic persistent contaminants were measured in blood, blood serum, and human milk of a large number of healthy donors. Sampling was carried out from 2008 to 2009. Blood was collected from over 850 20-64-year old donors; by pooling, 84 blood and 84 serum samples were obtained. Milk was donated by 52 mothers: specimens were pooled into six samples. Polychlorodibenzodioxins (PCDDs), polychlorodibenzofurans (PCDFs), and polychlorobiphenyls (PCBs, dioxin-like (DL) and non-dioxin-like (Σ6PCBs)), arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) were measured in serum (organic biomarkers) and blood (metals); these chemicals and polybromobiphenyl ethers (Σ9PBDEs) were analyzed in milk. PCDD+PCDF, DL-PCB, TEQTOT, and Σ6PCB concentration ranges (medians) in serum were 6.26-23.1 (12.4), 3.42-31.7 (11.5), 10.0-52.8 (23.9) pgTEQ97/g fat, and 55.5-647 (219) ng/g fat, respectively, while in milk concentration ranges were 5.99-8.77, 4.02-6.15, 10.0-14.2 pgTEQ97/g fat, and 48.7-74.2 ng/g fat. Likewise, As, Cd, Hg, and Pb findings in blood spanned 2.34-13.4 (5.83), 0.180-0.930 (0.475), 1.09-7.60 (2.60), 10.2-55.9 (28.8) μg/L, respectively; only Pb could be measured in milk (2.78-5.99 μg/L). Σ9PBDE levels in milk samples were 0.965-6.05 ng/g fat. Biomarkers' concentrations were found to be compatible with their current values in European countries and in Italy, and consistent with an exposure primarily determined by consumption of commercial food from the large distribution system. Based on relatively higher biomarker values within the hematic biomonitoring database, the following municipalities were flagged as possibly deserving attention for health-oriented interventions: Brusciano and Caivano (As), Giugliano (Hg), Pianura (PCDDs+PCDFs), and Qualiano-Villaricca (As, Hg). The analysis of samples' qualitative variability indicated that biomarker composition was sensitive at municipality level, a feature that can potentially drive interventions for future local risk assessment and/or management measures., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2014
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16. Cancer incidence in people with AIDS in Italy.

Author

Polesel J, Franceschi S, Suligoi B, Crocetti E, Falcini F, Guzzinati S, Vercelli M, Zanetti R, Tagliabue G, Russo A, Luminari S, Stracci F, De Lisi V, Ferretti S, Mangone L, Budroni M, Limina RM, Piffer S, Serraino D, Bellù F, Giacomin A, Donato A, Madeddu A, Vitarelli S, Fusco M, Tessandori R, Tumino R, Piselli P, Dal Maso L, Lise M, Zucchetto A, De Paoli A, Intrieri T, Vattiato R, Zambon P, Puppo A, Patriarca S, Tittarelli A, Autelitano M, Cirilli C, La Rosa F, Sgargi P, Di Felice E, Cesaraccio R, Donato F, Franchini S, Zanier L, Vittadello F, Vercellino PC, Senatore G, Contrino ML, Antonini S, Palombino R, Maspero S, La Rosa MG, Camoni L, and Regine V

Subjects
Humans, Incidence, Italy epidemiology, Neoplasms complications, Acquired Immunodeficiency Syndrome complications, Neoplasms epidemiology
Abstract

People with HIV/AIDS (PWHA) have increased risk of some cancers. The introduction of highly active antiretroviral therapies (HAART) has improved their life expectancy, exposing them to the combined consequences of aging and of a prolonged exposure to cancer risk factors. The aim of this study was to estimate incidence rates (IR) in PWHA in Italy, before and after the introduction of HAART, after adjusting for sex and age through direct standardization. An anonymous record linkage between Italian AIDS Registry (21,951 cases) and Cancer Registries (17.3 million, 30% of Italian population) was performed. In PWHA, crude IR, sex- and age-standardized IR and age-specific IR were estimated. The standardized IR for Kaposi sarcoma and non-Hodgkin lymphoma greatly declined in the HAART period. Although the crude IR for all non-AIDS-defining cancers increased in the HAART period, standardized IR did not significantly differ in the 2 periods (352 and 379/100,000, respectively). Increases were seen only for cancer of the liver (IR ratio = 4.6, 95% CI: 1.3-17.0) and lung (IR ratio = 1.8, 95% CI: 1.0-3.2). Age-specific IRs for liver and lung cancers, however, largely overlapped in the 2 periods pointing to the strong influence of the shift in the age distribution of PWHA on the observed upward trends. In conclusion, standardized IRs for non-AIDS-defining cancers have not risen in the HAART period, even if crude IRs of these cancers increased. This scenario calls, however, for the intensification of cancer-prevention strategies, notably smoking cessation and screening programs, in middle-aged HIV-patients.

Published
2010
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17. Epidemiology of viral hepatitis infections in an area of southern Italy with high incidence rates of liver cancer.

Author

Fusco M, Girardi E, Piselli P, Palombino R, Polesel J, Maione C, Scognamiglio P, Pisanti FA, Solmone M, Di Cicco P, Ippolito G, Franceschi S, and Serraino D

Subjects
Adult, Age Distribution, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Incidence, Italy epidemiology, Male, Middle Aged, Sex Distribution, Hepatitis B, Chronic epidemiology, Hepatitis C, Chronic epidemiology, Liver Neoplasms epidemiology
Abstract

Southern Italy shows the highest rates of liver cancer for Europe, mainly related to infection with hepatitis viruses. We thus described incidence rates of liver cancer and investigated prevalence and determinants of HCV and HBV infections in 4496 individuals randomly selected from the general population of the province of Naples. 7.5% was infected with HCV and 27.6% with HBV (2.2% was HBsAg-positive). Prevalence of both infections increased with age, 23.2% of those aged 65 years or older was HCV-positive and 47.9% were HBV-positive. Intravenous drug use (odds ratio (OR)=16.4 for anti-HCV and 4.7 for anti-HBc), history of blood transfusions (OR=2.8 and 1.5, respectively) and surgery, and household contacts with infected people (OR=2.1 and 1.6, respectively) increased risks for both infections. Sexual intercourse with HCV-positive individuals conveyed a 3-fold higher risk of HCV infection. This study quantified the spread of HCV and HBV in the population of southern Italy heavily affected by liver cancer.

Published
2008
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18. [Measles in the Local Health Unit Naples 4: vaccination coverage, epidemic 2001-2002 and prevention strategies].

Author

Gigli L, Graziano M, Manetta G, and Palombino R

Subjects
Adolescent, Child, Child, Preschool, Female, Humans, Immunization Programs, Infant, Italy epidemiology, Male, Measles epidemiology, Measles prevention & control, Measles Vaccine administration & dosage
Abstract

The authors have analysed vaccination coverage for measles. The active offer of the vaccine brought about an increase of the vaccination coverage but participation to vaccination proved unsatisfactory between 1995 and 2000. The measles epidemic reported 1367 cases, of which 125 were hospitalised (3 cases presented complications). The target for the next years is to reach a vaccination coverage of 95% or more and recuperate the non vaccinated, starting with the 1990 birth cohort.

Published
2004

19. Epidemiology of diabetes mellitus in southern Italy: a case-finding method based on drug prescriptions.

Author

Vaccaro O, Imperatore G, Ferrara A, Palombino R, and Riccardi G

Subjects
Adolescent, Adult, Aged, Child, Data Collection methods, Diabetes Mellitus drug therapy, Female, Humans, Italy epidemiology, Male, Middle Aged, National Health Programs, Predictive Value of Tests, Prevalence, Sensitivity and Specificity, Diabetes Mellitus epidemiology, Drug Prescriptions, Epidemiologic Methods
Abstract

The study evaluates whether data concerning drug prescriptions available from the National Health System (NHS) can be used to provide an estimate of the prevalence and pattern of treatment of diabetes in a well defined health district in southern Italy. In Italy virtually all drug prescriptions are obtained through the NHS. For a period of three consecutive months all prescriptions of insulin, hypoglycemic agents and strips for blood and urine testing were monitored in a well defined area near Naples. 2958 cases were thus identified giving a prevalence of drug treated diabetes mellitus of 2.01%; prevalence was higher in females than in males (2.68 vs 1.35%) and increased with age from 0.05% in the age group below 9 years to 13.67 in the age group over 70 years. This case-finding procedure was validated by cross-check with independent sources of cases. To evaluate the sensitivity of the method a list of 820 "known" cases of drug treated diabetes mellitus was obtained from a random sample of local general practitioners (GPs) and diabetic clinics: 73.5% of these cases were also detected through the analysis of drug prescriptions. To evaluate the probability of misclassification a random subsample of 602 cases identified through prescriptions was submitted to the GPs working in the study area, for 517 the diagnosis of diabetes was confirmed, thus yielding a positive predictive value of 85.9%. After correction for sensitivity and probability of misclassification the prevalence of drug treated diabetes in our population was 2.52%. The pattern of prescriptions in this population is also given.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1992
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20. The control of human brucellosis in the Campania region: an updating of knowledge and results obtained by the third year of the programme activities.

Author

Palombino R, Palumbo F, Petti A, Tagliafierro S, Mantovani A, and Scorziello M

Subjects
Animals, Brucellosis epidemiology, Brucellosis veterinary, Humans, Incidence, Italy epidemiology, Population Surveillance, Program Evaluation, Public Health, Brucellosis prevention & control
Abstract

A control programme for brucellosis in Campania was started in 1988, in the province of Caserta, and implied different actions at the regional and provincial levels. The section of the work described here regards the updating of the results obtained during the third year of the project activity. The action performed included experimentation of data sheets in the province of Caserta to gain information on the factors conditioning brucellosis, gathering and analysis of ISTAT data on the size of livestock population as an actual or potential source of infection for man, epidemiological surveillance of human cases, census of dairies, and public health measures taken by the Regional Council. The results show that improvement of human brucellosis surveillance is in progress, whereas the programme implementation has provided a clearer picture of the situation with better understanding of the factors affecting the disease occurrence. Such problems posed by the project management as difficult maintenance of sufficient collaboration between veterinarians and physicians, scarce participation of local and regional administrations, resistance opposed by some categories, and reduced availability of financial resources are also discussed.

Published
1992

21. [Brucellosis control program in the Campania Region].

Author

Palombino R, Palumbo F, Scorziello M, Vitolini O, and Mantovani A

Subjects
Brucellosis epidemiology, Brucellosis transmission, Epidemiologic Methods, Health Education, Humans, Italy epidemiology, Surveys and Questionnaires, Brucellosis prevention & control
Published
1990

22. [Brucellosis in the Campania region].

Author

Palombino R, Palumbo F, and Gigli L

Subjects
Brucellosis prevention & control, Cluster Analysis, Cohort Studies, Disease Outbreaks, Humans, Italy epidemiology, Brucellosis epidemiology
Abstract

The research describes the trend of brucellosis, in the period 1984-86, in the county of the "regione Campania". This trend, in contrast with the national one, is manifested as endemic, with frequent and localised outbreaks of epidemic levels. The research also describes, through the analysis of the illness registration forms of 762 cases of brucellosis in the period 1985-86, the seasonal trend, the ages of major risk of infection and the most frequent modes of infection. The paper concludes with suggestions for the effective prevention of brucellosis.

Published
1989

23. [Antitetanus prophylaxis: actual practice and cost benefit analysis of a hypothetical mass vaccination].

Author

Palombino R, Greco M, Morra G, and Pitzurra M

Subjects
Adolescent, Adult, Female, Health Policy, Humans, Immunization, Passive, Male, Tetanus Toxoid immunology, Tetanus prevention & control, Tetanus Toxoid therapeutic use, Vaccination
Abstract

The actual practice of immunoprophylaxis in a Sanitary District of Campania (Italy) is described. As everywhere in Italy, in subjects at risk (wounded) the passive immunoprophylaxis by human specific immunoglobins is currently applied: at very high cost and with unreliable protection. The Authors suggest to implement antitetanus mass vaccination, with benefits incoming from lower expenses and higher protection.

Published
1987

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